Oncotarget | Tumor hyaluronan as a novel biomarker in non-small cell lung cancer: A retrospective study

News, Oncotarget

November 9, 2022
Research Article

“To the best of our knowledge, there have only been 2 other studies (both retrospective) investigating the prognostic potential of HA in NSCLC patients [5, 6].”

BUFFALO, NY- November 9, 2022 – A new research paper was published in Oncotarget’s Volume 13 on November 2, 2022, entitled, “Tumor hyaluronan as a novel biomarker in non-small cell lung cancer: A retrospective study.”

Hyaluronan (HA) accumulation is associated with tumorigenesis and aggressive tumor behavior. In a new study, researchers Jun Gong, Michelle Guan, Haesoo Kim, Natalie Moshayedi, Sejal Mehta, Galen Cook-Wiens, Brent K. Larson, Jenny Zhou, Rishi Patel, Isaac Lapite, Veronica R. Placencio-Hickok, Richard Tuli, Ronald B. Natale, and Andrew E. Hendifar from Cedars-Sinai Medical Center and Memorial Sloan Kettering Cancer Center investigated the biomarker potential of HA in non-small cell lung cancer (NSCLC).

“The purpose of this study was to evaluate the significance of HA as a potential biomarker in NSCLC. Specifically, we investigated the prognostic and predictive value of tumor HA levels in a large cohort of predominantly advanced-stage NSCLC patients.”

HA levels were scored using affinity histochemistry in 137 NSCLC samples stratified by HA score ≤10, 11–20, 21–30, and >30 with HA-high defined as ≥25% expression in the extracellular matrix (ECM) of the tumor surface area. Overall survival (OS) and time to progression from initiation of taxane therapy (TTP) were compared using log-rank tests based on HA score.

Of 122 patients with recurrent/metastatic NSCLC, 93 had mean HA scores that were not significantly different across clinicopathologic variables. Frequency of HA-high tumors did not differ by histology (34/68 adenocarcinomas vs. 12/25 squamous tumors, Fisher’s p = 1.0000). Median OS for recurrent/metastatic adenocarcinoma was 35.5 months (95%, 23.6–50.3) vs. 17.9 months for squamous (95%, 12.7–37.0, log-rank test, p = 0.0165). OS was not significantly different by HA quartiles, high or low (<25) HA score and tumor histology, and HA biopsy site (all p > 0.05). Median TTP (n = 98) significantly differed by HA quartile (2.8 months for HA score ≤10; 5.0 months for 11–20; 7.9 months for 21–30; 3.9 months for >30, p = 0.0265). Improved TTP trended in HA-high over HA-low tumors (n = 98, p = 0.0911).

“In this NSCLC cohort, tumor HA level represents a potential biomarker for TTP, which remains a cornerstone of NSCLC therapy. Further validation is warranted to identify the HA accumulation threshold associated with clinical benefit.”

Key messages:

  • Tumor HA level represents a potential biomarker for taxane therapy, which remains a cornerstone of systemic therapy in NSCLC.
  • Median OS for recurrent/metastatic adenocarcinoma was 35.5 months vs. 17.9 months for squamous.
  • Median taxane TTP significantly differed by HA quartile.

DOI: https://doi.org/10.18632/oncotarget.28304 

Correspondence to: Andrew E. Hendifar

Email: andrew.hendifar@cshs.org 

Keywords: hyaluronan, hyaluronic acid, biomarker, prognostic, predictive

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