Oncoscience | A murine model for human early/immature T-cell precursor acute lymphoblastic leukemia (EITP ALL)

News, Oncoscience

January 23, 2023
Research Article

“As anticipated, we found that the onset of leukemia was significantly accelerated in Idh2R140Q/NHD13 double transgenic mice […]”

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BUFFALO, NY- January 23, 2023 – A new research perspective was published in Oncoscience (Volume 9) on October 24, 2022, entitled, “A murine model for human early/immature T-cell precursor acute lymphoblastic leukemia (EITP ALL).”

In this research perspective, researchers Vijay Negi and Peter D. Aplan from the National Institutes of Health’s National Cancer Institute discussed early/immature T cell precursor acute lymphoblastic leukemia (EITP ALL). EITP ALL represents a subset of human leukemias distinct from other T-ALL, and associated with poor prognosis. Clinical studies have identified chromosomal translocations involving the NUP98 gene and point mutations of IDH genes as recurrent mutations in patients with EITP-ALL. 

“In a recent study using genetically engineered mice, we demonstrated that cooperation of an Idh2R140Q mutation with a NUP98-HOXD13 (NHD13) fusion gene resulted in EITP-ALL.”

Highlights of this double transgenic mouse model included the similarity of the immunophenotypic, mutational and gene expression landscape with human EITP-ALL. Additional studies showed that the Idh2R140Q/NHD13 EITP-ALL are sensitive to selective mutant IDH2 inhibitors in vitro, leading to the possibility that these mice can serve as a useful model for the study of EITP ALL development and therapy.

“We predict that the Idh2R140Q/NHD13 mouse model will serve as an excellent tool to study EITP biology and identify therapies for patients with EITP leukemia.”

DOI: https://doi.org/10.18632/oncoscience.567 

Correspondence to: Peter D. Aplan – Email: aplanp@mail.nih.gov 

Keywords: early thymocyte precursor (ETP), leukemia, IDH2, NUP98, NHD13

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