“From Osimertinib to Preemptive Combinations” by Dr. Blagosklonny

“Here I will re-introduce the notion of preemptive combinations (PC) of targeted drugs.”

BUFFALO, NY- March 19, 2024 – A new research perspective was published by Mikhail V. Blagosklonny M.D., Ph.D., from Roswell Park Comprehensive Cancer Center in Oncotarget's Volume 15 on March 15, 2024, entitled, “From osimertinib to preemptive combinations.”

“Here, I suggest that while first-line osimertinib extends median progression-free survival (PFS) in EGFR-mutant lung cancer compared to first-generation TKIs, it reduces individual PFS in 15–20% of patients compared to first-generation TKIs. Since detecting a single resistant cell before treatment is usually impossible, osimertinib must be used in all patients as a first-line treatment, raising median PFS overall but harming some. 

The simplest remedy is a preemptive combination (PC) of osimertinib and gefitinib. A comprehensive PC (osimertinib, afatinib/gefitinib, and capmatinib) could dramatically increase PFS for 80% of patients compared to osimertinib alone, without harming anyone. This article also explores PCs for MET-driven lung cancer.”

Continue reading: DOI: https://doi.org/10.18632/oncotarget.28569 

Correspondence to: Mikhail V. Blagosklonny

Emails: [email protected], [email protected] 

Keywords: lung cancer NSCLC, EGFR, resistance, afatinib, gefitinib, capmatinib

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