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Research Perspectives:

The tumor suppressor p53 connects ribosome biogenesis to cell cycle control: a double-edged sword

Michael Hölzel, Kaspar Burger, Bastian Mühl, Mathias Orban, Markus Kellner, Dirk Eick _

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Abstract

Received: Februrary 23, 2010, Accepted: April 18, 2010, Published: May 1, 2010

Since its first description more than 30 years ago p53 has become a paradigm for a protein with versatile functions. P53 sensitizes a large variety of genetic alterations and has been entitled the guardian of the genome. Stabilization of p53 upon DNA damage is accompanied by a complex pattern of modifications, which ascertain the cellular response either in the direction of a reversible or irreversible cell cycle arrest or programmed cell death. More recently it became evident that p53 also responds to non-genotoxic cell stress, in particular if ribosome biogenesis is affected.

 

Author Information

Michael Hölzel
current address: Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, Netherlands

Kaspar Burger
Department of Molecular Epigenetics, Center of Integrated Protein Science (CIPSM), Helmholtz Center Munich, Munich, Germany

Bastian Mühl
Department of Molecular Epigenetics, Center of Integrated Protein Science (CIPSM), Helmholtz Center Munich, Munich, Germany

Mathias Orban
Department of Molecular Epigenetics, Center of Integrated Protein Science (CIPSM), Helmholtz Center Munich, Munich, Germany

Markus Kellner
Department of Molecular Epigenetics, Center of Integrated Protein Science (CIPSM), Helmholtz Center Munich, Munich, Germany

Dirk Eick
Primary Contact  _

Department of Molecular Epigenetics, Center of Integrated Protein Science (CIPSM), Helmholtz Center Munich, Munich, Germany


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