Oncotarget

Vol 6, No 2

January 20, 2015

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About The Cover

ERα expression increases in prostate cancer. See Takizawa et al..

Table of Contents

Editorial

Base excision DNA repair and cancer

Base excision DNA repair and cancer

https://doi.org/10.18632/oncotarget.2705

Gianluca Tell,  and Bruce Demple
584-585
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TORC2 inhibition may boost DNA-damaging chemotherapy

TORC2 inhibition may boost DNA-damaging chemotherapy

https://doi.org/10.18632/oncotarget.3034

Manuel Stucki
586-587
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Predicting response to HER2 kinase inhibition

Predicting response to HER2 kinase inhibition

https://doi.org/10.18632/oncotarget.3036

Jeff Settleman
588-589
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Aging interventions get human

Aging interventions get human

https://doi.org/10.18632/oncotarget.3173

Brian K. Kennedy,  and Juniper K. Pennypacker
590-591
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Reviews

Androgen receptors beyond prostate cancer: an old marker as a new target

Androgen receptors beyond prostate cancer: an old marker as a new target

https://doi.org/10.18632/oncotarget.2831

Javier Munoz, Jennifer J. Wheler,  and Razelle Kurzrock
592-603
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Priority Research Papers

Estrogen receptor alpha drives proliferation in PTEN-deficient prostate carcinoma by stimulating survival signaling, MYC expression and altering glucose sensitivity

Estrogen receptor alpha drives proliferation in PTEN-deficient prostate carcinoma by stimulating survival signaling, MYC expression and altering glucose sensitivity

https://doi.org/10.18632/oncotarget.2820

Itsuhiro Takizawa, Mitchell G. Lawrence, Preetika Balanathan, Richard Rebello, Helen B. Pearson, Elika Garg, John Pedersen, Normand Pouliot, Robert Nadon, Matthew J. Watt, Renea A. Taylor, Patrick Humbert, Ivan Topisirovic, Ola Larsson, Gail P. Risbridger,  and Luc Furic
604-616
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Screening analysis of ubiquitin ligases reveals G2E3 as a potential target for chemosensitizing cancer cells

Screening analysis of ubiquitin ligases reveals G2E3 as a potential target for chemosensitizing cancer cells

https://doi.org/10.18632/oncotarget.2710

Franziska Schmidt, Meike Kunze, Ann-Christine Loock,  and Matthias Dobbelstein
617-632
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Research Papers: Gerotarget (Focus on Aging)

Impact of age on the survival of patients with liver cancer: an analysis of 27,255 patients in the SEER database

Impact of age on the survival of patients with liver cancer: an analysis of 27,255 patients in the SEER database

https://doi.org/10.18632/oncotarget.2719

Wenjie Zhang,  and Beicheng Sun
633-641
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Synthetic Aβ peptides acquire prion-like properties in the brain

Synthetic Aβ peptides acquire prion-like properties in the brain

https://doi.org/10.18632/oncotarget.2819

Xiangzhu Xiao, Ignazio Cali, Jue Yuan, Laura Cracco, Paul Curtiss, Liang Zeng, Mai Abouelsaad, Dimitris Gazgalis, Gong-Xian Wang, Qingzhong Kong, Hisashi Fujioka, Gianfranco Puoti,  and Wen-Quan Zou
642-650
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Research Papers

Targeting the facilitative glucose transporter GLUT1 inhibits the self-renewal and tumor-initiating capacity of cancer stem cells

Targeting the facilitative glucose transporter GLUT1 inhibits the self-renewal and tumor-initiating capacity of cancer stem cells

https://doi.org/10.18632/oncotarget.2892

Keita Shibuya, Masashi Okada, Shuhei Suzuki, Manabu Seino, Shizuka Seino, Hiroyuki Takeda,  and Chifumi Kitanaka
651-661
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Inhibition of the Warburg effect with a natural compound reveals a novel measurement for determining the metastatic potential of breast cancers

Inhibition of the Warburg effect with a natural compound reveals a novel measurement for determining the metastatic potential of breast cancers

https://doi.org/10.18632/oncotarget.2689

Ritu Arora, David Schmitt, Balasubramanyam Karanam, Ming Tan, Clayton Yates,  and Windy Dean-Colomb
662-678
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IL-1RT1 signaling antagonizes IL-11 induced STAT3 dependent cardiac and antral stomach tumor development through myeloid cell enrichment

IL-1RT1 signaling antagonizes IL-11 induced STAT3 dependent cardiac and antral stomach tumor development through myeloid cell enrichment

https://doi.org/10.18632/oncotarget.2707

Jon N Buzzelli, Dan I Pavlic, Heather V Chalinor, Louise O’Connor, Trevelyan R Menheniott, Andrew S Giraud,  and Louise M Judd
679-695
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Cyclin E1 and RTK/RAS signaling drive CDK inhibitor resistance via activation of E2F and ETS

Cyclin E1 and RTK/RAS signaling drive CDK inhibitor resistance via activation of E2F and ETS

https://doi.org/10.18632/oncotarget.2673

Barbie Taylor-Harding, Paul-Joseph Aspuria, Hasmik Agadjanian, Dong-Joo Cheon, Takako Mizuno, Danielle Greenberg, Jenieke R. Allen, Lindsay Spurka, Vincent Funari, Elizabeth Spiteri, Qiang Wang, Sandra Orsulic, Christine Walsh, Beth Y. Karlan,  and Ruprecht W. Wiedemeyer
696-714
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Cancer exosomes trigger mesenchymal stem cell differentiation into pro-angiogenic and pro-invasive myofibroblasts

Cancer exosomes trigger mesenchymal stem cell differentiation into pro-angiogenic and pro-invasive myofibroblasts

https://doi.org/10.18632/oncotarget.2711

Ridwana Chowdhury, Jason P. Webber, Mark Gurney, Malcolm D. Mason, Zsuzsanna Tabi,  and Aled Clayton
715-731
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SWI/SNF complexes are required for full activation of the DNA-damage response

SWI/SNF complexes are required for full activation of the DNA-damage response

https://doi.org/10.18632/oncotarget.2715

Stephanie L. Smith-Roe, Jun Nakamura, Darcy Holley, Paul D. Chastain, Gary B. Rosson, Dennis A. Simpson, John R. Ridpath, David G. Kaufman, William K. Kaufmann,  and Scott J. Bultman
732-745
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A subgroup of pancreatic adenocarcinoma is sensitive to the 5-aza-dC DNA methyltransferase inhibitor

A subgroup of pancreatic adenocarcinoma is sensitive to the 5-aza-dC DNA methyltransferase inhibitor

https://doi.org/10.18632/oncotarget.2685

Odile Gayet, Celine Loncle, Pauline Duconseil, Marine Gilabert, Maria Belen Lopez, Vincent Moutardier, Olivier Turrini, Ezequiel Calvo, Jacques Ewald, Marc Giovannini, Mohamed Gasmi, Erwan Bories, Marc Barthet, Mehdi Ouaissi, Anthony Goncalves, Flora Poizat, Jean Luc Raoul, Veronique Secq, Stephane Garcia, Patrice Viens, Nelson Dusetti,  and Juan Iovanna
746-754
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The genomic landscape of fibrolamellar hepatocellular carcinoma: whole genome sequencing of ten patients

The genomic landscape of fibrolamellar hepatocellular carcinoma: whole genome sequencing of ten patients

https://doi.org/10.18632/oncotarget.2712

David G. Darcy, Rachel Chiaroni-Clarke, Jennifer M. Murphy, Joshua N. Honeyman, Umesh Bhanot, Michael P. LaQuaglia,  and Sanford M. Simon
755-770
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SKP2 inactivation suppresses prostate tumorigenesis by mediating JARID1B ubiquitination

SKP2 inactivation suppresses prostate tumorigenesis by mediating JARID1B ubiquitination

https://doi.org/10.18632/oncotarget.2718

Wenfu Lu, Shenji Liu, Bo Li, Yingqiu Xie, Christine Adhiambo, Qing Yang, Billy R. Ballard, Keiichi I. Nakayama, Robert J. Matusik,  and Zhenbang Chen
771-788
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P62 regulates resveratrol-mediated Fas/Cav-1 complex formation and transition from autophagy to apoptosis

P62 regulates resveratrol-mediated Fas/Cav-1 complex formation and transition from autophagy to apoptosis

https://doi.org/10.18632/oncotarget.2733

Jun Zhang, Ke Ma, Tingting Qi, Xiaoning Wei, Qing Zhang, Guanwu Li,  and Jen-Fu Chiu
789-801
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The PI3K inhibitor GDC-0941 displays promising in vitro and in vivo efficacy for targeted medulloblastoma therapy

The PI3K inhibitor GDC-0941 displays promising in vitro and in vivo efficacy for targeted medulloblastoma therapy

https://doi.org/10.18632/oncotarget.2742

Michael Ehrhardt, Rogerio B. Craveiro, Martin I. Holst, Torsten Pietsch,  and Dagmar Dilloo
802-813
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Short-hairpin RNA library: identification of therapeutic partners for gefitinib-resistant non-small cell lung cancer

Short-hairpin RNA library: identification of therapeutic partners for gefitinib-resistant non-small cell lung cancer

https://doi.org/10.18632/oncotarget.2891

Makoto Sudo, Seiichi Mori, Vikas Madan, Henry Yang, Geraldine Leong,  and H. Phillip Koeffler
814-824
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c-myc copy number gain is a powerful prognosticator of disease outcome in cervical dysplasia

c-myc copy number gain is a powerful prognosticator of disease outcome in cervical dysplasia

https://doi.org/10.18632/oncotarget.2706

Kirsten Kübler, Sally Heinenberg, Christian Rudlowski, Mignon-Denise Keyver-Paik, Alina Abramian, Sabine Merkelbach-Bruse, Reinhard Büttner, Walther Kuhn,  and Hans-Ulrich Schildhaus
825-835
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The inverse relationship between bladder and liver in 4-aminobiphenyl-induced DNA damage

The inverse relationship between bladder and liver in 4-aminobiphenyl-induced DNA damage

https://doi.org/10.18632/oncotarget.2722

Arup Bhattacharya, Joshua J. Klaene, Yun Li, Joseph D. Paonessa, Aimee B. Stablewski, Paul Vouros,  and Yuesheng Zhang
836-845
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PKM2 promotes metastasis by recruiting myeloid-derived suppressor cells and indicates poor prognosis for hepatocellular carcinoma

PKM2 promotes metastasis by recruiting myeloid-derived suppressor cells and indicates poor prognosis for hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.2749

Wei-Ren Liu, Meng-Xin Tian, Liu-Xiao Yang, Yu-Li Lin, Lei Jin, Zhen-Bin Ding, Ying-Hao Shen, Yuan-Fei Peng, Dong-Mei Gao, Jian Zhou, Shuang-Jian Qiu, Zhi Dai, Rui He, Jia Fan,  and Ying-Hong Shi
846-861
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The ubiquitin ligase Siah is a novel regulator of Zeb1 in breast cancer

The ubiquitin ligase Siah is a novel regulator of Zeb1 in breast cancer

https://doi.org/10.18632/oncotarget.2696

Anna Chen, Christina S.F. Wong, Mira C.P. Liu, Colin M. House, Jaclyn Sceneay, David D. Bowtell, Erik W. Thompson,  and Andreas Möller
862-873
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

TWIST1 and TWIST2 promoter methylation and protein expression in tumor stroma influence the epithelial-mesenchymal transition-like tumor budding phenotype in colorectal cancer

TWIST1 and TWIST2 promoter methylation and protein expression in tumor stroma influence the epithelial-mesenchymal transition-like tumor budding phenotype in colorectal cancer

https://doi.org/10.18632/oncotarget.2716

José A. Galván, Melina Helbling, Viktor H. Koelzer, Mario P. Tschan, Martin D. Berger, Marion Hädrich, Beat Schnüriger, Eva Karamitopoulou, Heather Dawson, Daniel Inderbitzin, Alessandro Lugli,  and Inti Zlobec
874-885
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HDAC2 deregulation in tumorigenesis is causally connected to repression of immune modulation and defense escape

HDAC2 deregulation in tumorigenesis is causally connected to repression of immune modulation and defense escape

https://doi.org/10.18632/oncotarget.2816

Mariarosaria Conte, Carmela Dell’Aversana, Rosaria Benedetti, Francesca Petraglia, Annamaria Carissimo, Valeria Belsito Petrizzi, Alfonso Maria D’Arco, Ciro Abbondanza, Angela Nebbioso,  and Lucia Altucci
886-901
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

An HSV-2 based oncolytic virus can function as an attractant to guide migration of adoptively transferred T cells to tumor sites

An HSV-2 based oncolytic virus can function as an attractant to guide migration of adoptively transferred T cells to tumor sites

https://doi.org/10.18632/oncotarget.2817

Xinping Fu, Armando Rivera, Lihua Tao,  and Xiaoliu Zhang
902-914
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

DNA methylome analysis identifies epigenetic silencing of FHIT as a determining factor for radiosensitivity in oral cancer: an outcome-predicting and treatment-implicating study

DNA methylome analysis identifies epigenetic silencing of FHIT as a determining factor for radiosensitivity in oral cancer: an outcome-predicting and treatment-implicating study

https://doi.org/10.18632/oncotarget.2821

Hon-Yi Lin, Shih-Kai Hung, Moon-Sing Lee, Wen-Yen Chiou, Tze-Ta Huang, Chih-En Tseng, Liang-Yu Shih, Ru-Inn Lin, Jora M.J. Lin, Yi-Hui Lai, Chia-Bin Chang, Feng-Chun Hsu, Liang-Cheng Chen, Shiang-Jiun Tsai, Yu-Chieh Su, Szu-Chi Li, Hung-Chih Lai, Wen-Lin Hsu, Dai-Wei Liu, Chien-Kuo Tai, Shu-Fen Wu,  and Michael W.Y. Chan
915-934
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

FGF8 promotes colorectal cancer growth and metastasis by activating YAP1

FGF8 promotes colorectal cancer growth and metastasis by activating YAP1

https://doi.org/10.18632/oncotarget.2822

Rui Liu, Shan Huang, Yunlong Lei, Tao Zhang, Kui Wang, Bo Liu, Edouard C. Nice, Rong Xiang, Ke Xie, Jingyi Li,  and Canhua Huang
935-952
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EphrinB1: novel microtubule associated protein whose expression affects taxane sensitivity

EphrinB1: novel microtubule associated protein whose expression affects taxane sensitivity

https://doi.org/10.18632/oncotarget.2823

Paul L. Colbert, Daniel W. Vermeer, Bryant G. Wieking, John H. Lee,  and Paola D. Vermeer
953-968
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Metformin and trametinib have synergistic effects on cell viability and tumor growth in NRAS mutant cancer

Metformin and trametinib have synergistic effects on cell viability and tumor growth in NRAS mutant cancer

https://doi.org/10.18632/oncotarget.2824

Igor Vujic, Martina Sanlorenzo, Christian Posch, Rosaura Esteve-Puig, Adam J. Yen, Andrew Kwong, Aaron Tsumura, Ryan Murphy, Klemens Rappersberger,  and Susana Ortiz-Urda
969-978
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Atypical ubiquitin E3 ligase complex Skp1-Pam-Fbxo45 controls the core epithelial-to-mesenchymal transition-inducing transcription factors

Atypical ubiquitin E3 ligase complex Skp1-Pam-Fbxo45 controls the core epithelial-to-mesenchymal transition-inducing transcription factors

https://doi.org/10.18632/oncotarget.2825

Ming Xu, Changhong Zhu, Xian Zhao, Cheng Chen, Hailong Zhang, Haihua Yuan, Rong Deng, Jinzhuo Dou, Yanli Wang, Jian Huang, Qin Chen, Bin Jiang,  and Jianxiu Yu
979-994
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Targeting of TGF-β-activated protein kinase 1 inhibits chemokine (C-C motif) receptor 7 expression, tumor growth and metastasis in breast cancer

Targeting of TGF-β-activated protein kinase 1 inhibits chemokine (C-C motif) receptor 7 expression, tumor growth and metastasis in breast cancer

https://doi.org/10.18632/oncotarget.2739

Hui-Ling Huang, Chi-Hsiang Chiang, Wen-Chun Hung,  and Ming-Feng Hou
995-1007
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Intrinsic TGF-β2-triggered SDF-1-CXCR4 signaling axis is crucial for drug resistance and a slow-cycling state in bone marrow-disseminated tumor cells

Intrinsic TGF-β2-triggered SDF-1-CXCR4 signaling axis is crucial for drug resistance and a slow-cycling state in bone marrow-disseminated tumor cells

https://doi.org/10.18632/oncotarget.2826

Takuya Nakamura, Satoru Shinriki, Hirofumi Jono, Jianying Guo, Mitsuharu Ueda, Mitsuhiro Hayashi, Satoshi Yamashita, Andries Zijlstra, Hideki Nakayama, Akimitsu Hiraki, Masanori Shinohara,  and Yukio Ando
1008-1019
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Silencing of CXCR4 sensitizes triple-negative breast cancer cells to cisplatin

Silencing of CXCR4 sensitizes triple-negative breast cancer cells to cisplatin

https://doi.org/10.18632/oncotarget.2741

Sixian Liang, Xun Peng, Xiaoli Li, Ping Yang, Linhao Xie, Yaochen Li, Caiwen Du,  and Guojun Zhang
1020-1030
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Reciprocal activation between IL-6/STAT3 and NOX4/Akt signalings promotes proliferation and survival of non-small cell lung cancer cells

Reciprocal activation between IL-6/STAT3 and NOX4/Akt signalings promotes proliferation and survival of non-small cell lung cancer cells

https://doi.org/10.18632/oncotarget.2671

Juan Li, Tian Lan, Cuixiang Zhang, Cheng Zeng, Jincai Hou, Zhicheng Yang, Min Zhang, Jianxun Liu,  and Bing Liu
1031-1048
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ZHX2 enhances the cytotoxicity of chemotherapeutic drugs in liver tumor cells by repressing MDR1 via interfering with NF-YA

ZHX2 enhances the cytotoxicity of chemotherapeutic drugs in liver tumor cells by repressing MDR1 via interfering with NF-YA

https://doi.org/10.18632/oncotarget.2832

Hongxin Ma, Xuetian Yue, Lifen Gao, Xiaohong Liang, Wenjiang Yan, Zhenyu Zhang, Haixia Shan, Hualin Zhang, Brett T. Spear,  and Chunhong Ma
1049-1063
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Knockdown of a novel lincRNA AATBC suppresses proliferation and induces apoptosis in bladder cancer

Knockdown of a novel lincRNA AATBC suppresses proliferation and induces apoptosis in bladder cancer

https://doi.org/10.18632/oncotarget.2833

Fengjin Zhao, Tianxin Lin, Wang He, Jinli Han, Dingjun Zhu, Kaishun Hu, Weicong Li, Zaosong Zheng, Jian Huang,  and Wenlian Xie
1064-1078
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Targeted Hsp70 expression combined with CIK-activated immune reconstruction synergistically exerts antitumor efficacy in patient-derived hepatocellular carcinoma xenograft mouse models

Targeted Hsp70 expression combined with CIK-activated immune reconstruction synergistically exerts antitumor efficacy in patient-derived hepatocellular carcinoma xenograft mouse models

https://doi.org/10.18632/oncotarget.2835

Huanzhang Hu, Yinghe Qiu, Minggao Guo, Yao Huang, Lin Fang, Zhangxiao Peng, Weidan Ji, Yang Xu, Shuwen Shen, Yan Yan, Xuandong Huang, Junnian Zheng,  and Changqing Su
1079-1089
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The microRNA-218~Survivin axis regulates migration, invasion, and lymph node metastasis in cervical cancer

The microRNA-218~Survivin axis regulates migration, invasion, and lymph node metastasis in cervical cancer

https://doi.org/10.18632/oncotarget.2836

Ryunosuke Kogo, Christine How, Naz Chaudary, Jeff Bruce, Wei Shi, Richard P. Hill, Payam Zahedi, Kenneth W. Yip,  and Fei-Fei Liu
1090-1100
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MicroRNA-130a associates with ribosomal protein L11 to suppress c-Myc expression in response to UV irradiation

MicroRNA-130a associates with ribosomal protein L11 to suppress c-Myc expression in response to UV irradiation

https://doi.org/10.18632/oncotarget.2728

Yuhuang Li, Kishore B Challagundla, Xiao-Xin Sun, Qinghong Zhang,  and Mu-Shui Dai
1101-1114
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Whole exome sequencing identifies a recurrent RQCD1 P131L mutation in cutaneous melanoma

Whole exome sequencing identifies a recurrent RQCD1 P131L mutation in cutaneous melanoma

https://doi.org/10.18632/oncotarget.2747

Stephen Q. Wong, Andreas Behren, Victoria J. Mar, Katherine Woods, Jason Li, Claire Martin, Karen E. Sheppard, Rory Wolfe, John Kelly, Jonathan Cebon, Alexander Dobrovic,  and Grant A. McArthur
1115-1127
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Zoledronic acid overcomes chemoresistance and immunosuppression of malignant mesothelioma

Zoledronic acid overcomes chemoresistance and immunosuppression of malignant mesothelioma

https://doi.org/10.18632/oncotarget.2731

Iris Chiara Salaroglio, Ivana Campia, Joanna Kopecka, Elena Gazzano, Sara Orecchia, Dario Ghigo,  and Chiara Riganti
1128-1142
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Lysosomal sequestration of hydrophobic weak base chemotherapeutics triggers lysosomal biogenesis and lysosome-dependent cancer multidrug resistance

Lysosomal sequestration of hydrophobic weak base chemotherapeutics triggers lysosomal biogenesis and lysosome-dependent cancer multidrug resistance

https://doi.org/10.18632/oncotarget.2732

Benny Zhitomirsky,  and Yehuda G. Assaraf
1143-1156
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Mitochondrial p32 is upregulated in Myc expressing brain cancers and mediates glutamine addiction

Mitochondrial p32 is upregulated in Myc expressing brain cancers and mediates glutamine addiction

https://doi.org/10.18632/oncotarget.2708

Valentina Fogal, Ivan Babic, Ying Chao, Sandra Pastorino, Rajesh Mukthavaram, Pengfei Jiang, Yoon-Jae Cho, Sandeep C. Pingle, John R. Crawford, David E. Piccioni,  and Santosh Kesari
1157-1170
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Filamin C, a dysregulated protein in cancer revealed by label-free quantitative proteomic analyses of human gastric cancer cells

Filamin C, a dysregulated protein in cancer revealed by label-free quantitative proteomic analyses of human gastric cancer cells

https://doi.org/10.18632/oncotarget.2645

Jie Qiao, Shu-Jian Cui, Lei-Lei Xu, Si-Jie Chen, Jun Yao, Ying-Hua Jiang, Gang Peng, Cai-Yun Fang, Peng-Yuan Yang,  and Feng Liu
1171-1189
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Temozolomide resistance in glioblastoma occurs by miRNA-9-targeted PTCH1, independent of sonic hedgehog level

Temozolomide resistance in glioblastoma occurs by miRNA-9-targeted PTCH1, independent of sonic hedgehog level

https://doi.org/10.18632/oncotarget.2778

Jessian L. Munoz, Vivian Rodriguez-Cruz, Shakti H. Ramkissoon, Keith L. Ligon, Steven J. Greco,  and Pranela Rameshwar
1190-1201
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A switch from CD44+ cell to EMT cell drives the metastasis of prostate cancer

A switch from CD44+ cell to EMT cell drives the metastasis of prostate cancer

https://doi.org/10.18632/oncotarget.2841

Zhiqun Shang, Qiliang Cai, Minghao Zhang, Shimiao Zhu, Yuan Ma, Libin Sun, Ning Jiang, Jing Tian, Xiaodan Niu, Jiatong Chen, Yinghao Sun,  and Yuanjie Niu
1202-1216
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Dichloroacetate, a selective mitochondria-targeting drug for oral squamous cell carcinoma: a metabolic perspective of treatment

Dichloroacetate, a selective mitochondria-targeting drug for oral squamous cell carcinoma: a metabolic perspective of treatment

https://doi.org/10.18632/oncotarget.2721

Vitalba Ruggieri, Francesca Agriesti, Rosella Scrima, Ilaria Laurenzana, Donatella Perrone, Tiziana Tataranni, Carmela Mazzoccoli, Lorenzo Lo Muzio, Nazzareno Capitanio,  and Claudia Piccoli
1217-1230
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Aspartate β-hydroxylase expression promotes a malignant pancreatic cellular phenotype

Aspartate β-hydroxylase expression promotes a malignant pancreatic cellular phenotype

https://doi.org/10.18632/oncotarget.2840

Xiaoqun Dong, Qiushi Lin, Arihiro Aihara, Yu Li, Chiung-Kuei Huang, Waihong Chung, Qi Tang, Xuesong Chen, Rolf Carlson, Christina Nadolny, Gregory Gabriel, Mark Olsen,  and Jack R. Wands
1231-1248
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Histone demethylase RBP2 decreases miR-21 in blast crisis of chronic myeloid leukemia

Histone demethylase RBP2 decreases miR-21 in blast crisis of chronic myeloid leukemia

https://doi.org/10.18632/oncotarget.2859

Minran Zhou, Jiping Zeng, Xiaoming Wang, Xiangyu Wang, Tao Huang, Yue Fu, Ting Sun, Jihui Jia,  and Chunyan Chen
1249-1261
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The Na+/H+ exchanger (NHE1) as a novel co-adjuvant target in paclitaxel therapy of triple-negative breast cancer cells

The Na+/H+ exchanger (NHE1) as a novel co-adjuvant target in paclitaxel therapy of triple-negative breast cancer cells

https://doi.org/10.18632/oncotarget.2860

Schammim Ray Amith, Jodi Marie Wilkinson, Shairaz Baksh,  and Larry Fliegel
1262-1275
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miR-26a and miR-214 down-regulate expression of the PTEN gene in chronic lymphocytic leukemia, but not PTEN mutation or promoter methylation

miR-26a and miR-214 down-regulate expression of the PTEN gene in chronic lymphocytic leukemia, but not PTEN mutation or promoter methylation

https://doi.org/10.18632/oncotarget.2626

Zhi-Jian Zou, Lei Fan, Li Wang, Ji Xu, Run Zhang, Tian Tian, Jian-Yong Li,  and Wei Xu
1276-1285
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A class of genes in the HER2 regulon that is poised for transcription in breast cancer cell lines and expressed in human breast tumors

A class of genes in the HER2 regulon that is poised for transcription in breast cancer cell lines and expressed in human breast tumors

https://doi.org/10.18632/oncotarget.2676

Farah B. Rahmatpanah, Zhenyu Jia, Xin Chen, Jessica E. Char, Bozhao Men, Anna-Clara Franke, Frank E. Jones, Michael McClelland,  and Dan Mercola
1286-1301
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Clinical Research Papers

Cell type specific gene expression analysis of prostate needle biopsies resolves tumor tissue heterogeneity

Cell type specific gene expression analysis of prostate needle biopsies resolves tumor tissue heterogeneity

https://doi.org/10.18632/oncotarget.2744

Malte Krönig, Max Walter, Vanessa Drendel, Martin Werner, Cordula A. Jilg, Andreas S. Richter, Rolf Backofen, David McGarry, Marie Follo, Wolfgang Schultze-Seemann,  and Roland Schüle
1302-1314
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PIK3CA mutations in non-small cell lung cancer (NSCLC): Genetic heterogeneity, prognostic impact and incidence of prior malignancies

PIK3CA mutations in non-small cell lung cancer (NSCLC): Genetic heterogeneity, prognostic impact and incidence of prior malignancies

https://doi.org/10.18632/oncotarget.2834

Matthias Scheffler, Marc Bos, Masyar Gardizi, Katharina König, Sebastian Michels, Jana Fassunke, Carina Heydt, Helen Künstlinger, Michaela Ihle, Frank Ueckeroth, Kerstin Albus, Monika Serke, Ulrich Gerigk, Wolfgang Schulte, Karin Töpelt, Lucia Nogova, Thomas Zander, Walburga Engel-Riedel, Erich Stoelben, Yon-Dschun Ko, Winfried Randerath, Britta Kaminsky, Jens Panse, Carolin Becker, Martin Hellmich, Sabine Merkelbach-Bruse, Lukas C. Heukamp, Reinhard Büttner,  and Jürgen Wolf
1315-1326
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Molecular profiling of endometrial carcinoma precursor, primary and metastatic lesions suggests different targets for treatment in obese compared to non-obese patients

Molecular profiling of endometrial carcinoma precursor, primary and metastatic lesions suggests different targets for treatment in obese compared to non-obese patients

https://doi.org/10.18632/oncotarget.2675

Anna Berg, Erling A. Hoivik, Siv Mjøs, Frederik Holst, Henrica M. J. Werner, Ingvild L. Tangen, Amaro Taylor-Weiner, William J. Gibson, Kanthida Kusonmano, Elisabeth Wik, Jone Trovik, Mari K. Halle, Anne M. Øyan, Karl-Henning Kalland, Andrew D. Cherniack, Rameen Beroukhim, Ingunn Stefansson, Gordon B. Mills, Camilla Krakstad,  and Helga B. Salvesen
1327-1339
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