Oncotarget

Vol 5, No 24

December 30, 2014

View Archive »

Order a Reprint

About The Cover

Analysis of TAZ subcellular localization, Alexa flour 568-conjugated phalloidin to detect cytosolic F-actin. See Xiang et al.

Table of Contents

Reviews

Classification of current anticancer immunotherapies

Classification of current anticancer immunotherapies

https://doi.org/10.18632/oncotarget.2998

Lorenzo Galluzzi, Erika Vacchelli, José-Manuel Bravo-San Pedro, Aitziber Buqué, Laura Senovilla, Elisa Elena Baracco, Norma Bloy, Francesca Castoldi, Jean-Pierre Abastado, Patrizia Agostinis, Ron N. Apte, Fernando Aranda, Maha Ayyoub, Philipp Beckhove, Jean-Yves Blay, Laura Bracci, Anne Caignard, Chiara Castelli, Federica Cavallo, Estaban Celis, Vincenzo Cerundolo, Aled Clayton, Mario P. Colombo, Lisa Coussens, Madhav V. Dhodapkar, Alexander M. Eggermont, Douglas T. Fearon, Wolf H. Fridman, Jitka Fučíková, Dmitry I. Gabrilovich, Jérôme Galon, Abhishek Garg, François Ghiringhelli, Giuseppe Giaccone, Eli Gilboa, Sacha Gnjatic, Axel Hoos, Anne Hosmalin, Dirk Jäger, Pawel Kalinski, Klas Kärre, Oliver Kepp, Rolf Kiessling, John M. Kirkwood, Eva Klein, Alexander Knuth, Claire E. Lewis, Roland Liblau, Michael T. Lotze, Enrico Lugli, Jean-Pierre Mach, Fabrizio Mattei, Domenico Mavilio, Ignacio Melero, Cornelis J. Melief, Elizabeth A. Mittendorf, Lorenzo Moretta, Adekunke Odunsi, Hideho Okada, Anna Karolina Palucka, Marcus E. Peter, Kenneth J. Pienta, Angel Porgador, George C. Prendergast, Gabriel A. Rabinovich, Nicholas P. Restifo, Naiyer Rizvi, Catherine Sautès-Fridman, Hans Schreiber, Barbara Seliger, Hiroshi Shiku, Bruno Silva-Santos, Mark J. Smyth, Daniel E. Speiser, Radek Spisek, Pramod K. Srivastava, James E. Talmadge, Eric Tartour, Sjoerd H. Van Der Burg, Benoît J. Van Den Eynde, Richard Vile, Hermann Wagner, Jeffrey  S. Weber, Theresa L. Whiteside, Jedd D. Wolchok, Laurence Zitvogel, Weiping Zou,  and Guido Kroemer
12472-12508
Abstract  |  PDF  |  HTML  |  Order a Reprint

Priority Research Papers

Hypoxia-inducible factor 1 mediates TAZ expression and nuclear localization to induce the breast cancer stem cell phenotype

Hypoxia-inducible factor 1 mediates TAZ expression and nuclear localization to induce the breast cancer stem cell phenotype

https://doi.org/10.18632/oncotarget.2997

Lisha Xiang, Daniele M. Gilkes, Hongxia Hu, Naoharu Takano, Weibo Luo, Haiquan Lu, John W. Bullen, Debangshu Samanta, Houjie Liang,  and Gregg L. Semenza
12509-12527
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A unifying gene signature for adenoid cystic cancer identifies parallel MYB-dependent and MYB-independent therapeutic targets

A unifying gene signature for adenoid cystic cancer identifies parallel MYB-dependent and MYB-independent therapeutic targets

https://doi.org/10.18632/oncotarget.2985

Ruli Gao, Chunxia Cao, Min Zhang, Maria-Cecilia Lopez, Yuanqing Yan, Zirong Chen, Yoshitsugu Mitani, Li Zhang, Maria Zajac-Kaye, Bin Liu, Lizi Wu, Rolf Renne, Henry V. Baker, Adel El-Naggar,  and Frederic J. Kaye
12528-12542
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MYC regulates the non-coding transcriptome

MYC regulates the non-coding transcriptome

https://doi.org/10.18632/oncotarget.3033

Jonathan R. Hart, Thomas C. Roberts, Marc S. Weinberg, Kevin V. Morris,  and Peter K. Vogt
12543-12554
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Phosphorylation of Tip60 by p38α regulates p53-mediated PUMA induction and apoptosis in response to DNA damage

Phosphorylation of Tip60 by p38α regulates p53-mediated PUMA induction and apoptosis in response to DNA damage

https://doi.org/10.18632/oncotarget.2717

Yingxi Xu, Rong Liao, Na Li, Rong Xiang,  and Peiqing Sun
12555-12572
Abstract  |  PDF  |  HTML  |  Order a Reprint

Research Papers: Gerotarget (Focus on Aging)

Higher mortality and impaired elimination of bacteria in aged mice after intracerebral infection with E. coli are associated with an age-related decline of microglia and macrophage functions

Higher mortality and impaired elimination of bacteria in aged mice after intracerebral infection with E. coli are associated with an age-related decline of microglia and macrophage functions

https://doi.org/10.18632/oncotarget.2709

Sandra Schütze, Sandra Ribes, Annika Kaufmann, Anja Manig, Jörg Scheffel, Sandra Redlich, Stephanie Bunkowski, Uwe-Karsten Hanisch, Wolfgang Brück,  and Roland Nau
12573-12592
Abstract  |  PDF  |  HTML  |  Order a Reprint

Research Papers

Multidimensional analysis of gene expression reveals TGFB1I1-induced EMT contributes to malignant progression of astrocytomas

Multidimensional analysis of gene expression reveals TGFB1I1-induced EMT contributes to malignant progression of astrocytomas

https://doi.org/10.18632/oncotarget.2518

Yanwei Liu, Huimin Hu, Kuanyu Wang, Chuanbao Zhang, Yinyan Wang, Kun Yao, Pei Yang, Lei Han, Chunsheng Kang, Wei Zhang,  and Tao Jiang
12593-12606
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

B-Raf inhibitor vemurafenib in combination with temozolomide and fotemustine in the killing response of malignant melanoma cells

B-Raf inhibitor vemurafenib in combination with temozolomide and fotemustine in the killing response of malignant melanoma cells

https://doi.org/10.18632/oncotarget.2610

Wynand P. Roos, Steve Quiros, Andrea Krumm, Stephanie Merz, Olivier Jérôme Switzeny, Markus Christmann, Carmen Loquai,  and Bernd Kaina
12607-12620
Abstract  |  PDF  |  HTML  |  Order a Reprint

Neutrophils with protumor potential could efficiently suppress tumor growth after cytokine priming and in presence of normal NK cells

Neutrophils with protumor potential could efficiently suppress tumor growth after cytokine priming and in presence of normal NK cells

https://doi.org/10.18632/oncotarget.2181

Rui Sun, Jing Luo, Dong Li, Yu Shu, Chao Luo, Shan-Shan Wang, Jian Qin, Gui-Mei Zhang,  and Zuo-Hua Feng
12621-12634
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The p53 transcriptional pathway is preserved in ATMmutated and NOTCH1mutated chronic lymphocytic leukemias

The p53 transcriptional pathway is preserved in ATMmutated and NOTCH1mutated chronic lymphocytic leukemias

https://doi.org/10.18632/oncotarget.2211

Emmanouil Athanasakis, Elisabetta Melloni, Gian Matteo Rigolin, Chiara Agnoletto, Rebecca Voltan, Diego Vozzi, Elisa Piscianz, Ludovica Segat, Simeone Dal Monego, Antonio Cuneo, Paola Secchiero,  and Giorgio Zauli
12635-12645
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

PRK1/PKN1 controls migration and metastasis of androgen-independent prostate cancer cells

PRK1/PKN1 controls migration and metastasis of androgen-independent prostate cancer cells

https://doi.org/10.18632/oncotarget.2653

Cordula A. Jilg, Anett Ketscher, Eric Metzger, Barbara Hummel, Dominica Willmann, Vanessa Rüsseler, Vanessa Drendel, Axel Imhof, Manfred Jung, Henriette Franz, Stefanie Hölz, Malte Krönig, Judith M. Müller,  and Roland Schüle
12646-12664
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Androgen deprivation therapy prevents bladder cancer recurrence

Androgen deprivation therapy prevents bladder cancer recurrence

https://doi.org/10.18632/oncotarget.2851

Koji Izumi, Masataka Taguri, Hiroshi Miyamoto, Yoshinori Hara, Takeshi Kishida, Kimio Chiba, Tetsuo Murai, Kotaro Hirai, Kotaro Suzuki, Kiyoshi Fujinami, Teiichiro Ueki, Koichi Udagawa, Kazuo Kitami, Masatoshi Moriyama, Yasuhide Miyoshi, Futoshi Tsuchiya, Ichiro Ikeda, Kazuki Kobayashi, Maho Sato, Satoshi Morita, Kazumi Noguchi,  and Hiroji Uemura
12665-12674
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A role for BMP-induced homeobox gene MIXL1 in acute myelogenous leukemia and identification of type I BMP receptor as a potential target for therapy

A role for BMP-induced homeobox gene MIXL1 in acute myelogenous leukemia and identification of type I BMP receptor as a potential target for therapy

https://doi.org/10.18632/oncotarget.2564

Aaron Raymond, Bin Liu, Hong Liang, Ciamaio Wei, Michele Guindani, Yue Lu, Shoudan Liang, Lisa S. St. John, Jeff Molldrem,  and Lalitha Nagarajan
12675-12693
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Ferroxitosis: A cell death from modulation of oxidative phosphorylation and PKM2-dependent glycolysis in melanoma

Ferroxitosis: A cell death from modulation of oxidative phosphorylation and PKM2-dependent glycolysis in melanoma

https://doi.org/10.18632/oncotarget.3031

Alexander J. Lakhter, James Hamilton, Pierre C. Dagher, Suresh Mukkamala, Takashi Hato, X. Charlie Dong, Lindsey D. Mayo, Robert A. Harris, Anantha Shekhar, Mircea Ivan, Nickolay Brustovetsky,  and Samisubbu R. Naidu
12694-12703
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Mislocalization of p27 to the cytoplasm of breast cancer cells confers resistance to anti-HER2 targeted therapy

Mislocalization of p27 to the cytoplasm of breast cancer cells confers resistance to anti-HER2 targeted therapy

https://doi.org/10.18632/oncotarget.2871

Hui Zhao, Claire M. Faltermeier, Lori Mendelsohn, Peggy L. Porter, Bruce E. Clurman,  and James M. Roberts
12704-12714
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Tumor promoter-induced cellular senescence: cell cycle arrest followed by geroconversion

Tumor promoter-induced cellular senescence: cell cycle arrest followed by geroconversion

https://doi.org/10.18632/oncotarget.3011

Olga V. Leontieva,  and Mikhail V. Blagosklonny
12715-12727
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The angular structure of ONC201, a TRAIL pathway-inducing compound, determines its potent anti-cancer activity

The angular structure of ONC201, a TRAIL pathway-inducing compound, determines its potent anti-cancer activity

https://doi.org/10.18632/oncotarget.2890

Jessica Wagner, Christina Leah Kline, Richard S. Pottorf, Bhaskara Rao Nallaganchu, Gary L. Olson, David T. Dicker, Joshua E. Allen,  and Wafik S. El-Deiry
12728-12737
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Pre-clinical study of drug combinations that reduce breast cancer burden due to aberrant mTOR and metabolism promoted by LKB1 loss

Pre-clinical study of drug combinations that reduce breast cancer burden due to aberrant mTOR and metabolism promoted by LKB1 loss

https://doi.org/10.18632/oncotarget.2818

Rafaela Andrade-Vieira, Donna Goguen, Heidi A. Bentley, Chris V. Bowen,  and Paola A. Marignani
12738-12752
Abstract  |  PDF  |  HTML  |  Order a Reprint

The role of AXL and the in vitro activity of the receptor tyrosine kinase inhibitor BGB324 in Ewing sarcoma

The role of AXL and the in vitro activity of the receptor tyrosine kinase inhibitor BGB324 in Ewing sarcoma

https://doi.org/10.18632/oncotarget.2648

Emmy D.G. Fleuren, Melissa H.S. Hillebrandt-Roeffen, Uta E. Flucke, D. Maroeska W.M. te Loo, Otto C. Boerman, Winette T.A. van der Graaf,  and Yvonne M.H. Versleijen-Jonkers
12753-12768
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

End-binding 1 protein overexpression correlates with glioblastoma progression and sensitizes to Vinca-alkaloids in vitro and in vivo

End-binding 1 protein overexpression correlates with glioblastoma progression and sensitizes to Vinca-alkaloids in vitro and in vivo

https://doi.org/10.18632/oncotarget.2646

Raphael Berges, Nathalie Baeza-Kallee, Emeline Tabouret, Olivier Chinot, Marie Petit, Anna Kruczynski, Dominique Figarella-Branger, Stephane Honore,  and Diane Braguer
12769-12787
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Loss of compensatory pro-survival and anti-apoptotic modulator, IKKε, sensitizes ovarian cancer cells to CHEK1 loss through an increased level of p21

Loss of compensatory pro-survival and anti-apoptotic modulator, IKKε, sensitizes ovarian cancer cells to CHEK1 loss through an increased level of p21

https://doi.org/10.18632/oncotarget.2665

Marianne K. Kim, Dong J. Min, George Wright, Ian Goldlust,  and Christina M. Annunziata
12788-12802
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Pilot study of p62 DNA vaccine in dogs with mammary tumors

Pilot study of p62 DNA vaccine in dogs with mammary tumors

https://doi.org/10.18632/oncotarget.2516

Vladimir Gabai, Franco M. Venanzi, Elena Bagashova, Oksana Rud, Francesca Mariotti, Cecilia Vullo, Giuseppe Catone, Michael Y. Sherman, Antonio Concetti, Andrey Chursov, Anastasia Latanova, Vita Shcherbinina, Victor Shifrin,  and Alexander Shneider
12803-12810
Abstract  |  PDF  |  HTML  |  Order a Reprint

DEPTOR has growth suppression activity against pancreatic cancer cells

DEPTOR has growth suppression activity against pancreatic cancer cells

https://doi.org/10.18632/oncotarget.2659

Hua Li, Grace Y. Sun, Yongchao Zhao, Dafydd Thomas, Joel K. Greenson, Mark M. Zalupski, Edgar Ben-Josef,  and Yi Sun
12811-12819
Abstract  |  PDF  |  HTML  |  Order a Reprint

TAp73 promotes anabolism

TAp73 promotes anabolism

https://doi.org/10.18632/oncotarget.2667

Ivano Amelio, Alexey A. Antonov, Maria Valeria Catani, Renato Massoud, Francesca Bernassola, Richard A. Knight, Gerry Melino,  and Alessandro Rufini
12820-12934
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Co-treatment with therapeutic neural stem cells expressing carboxyl esterase and CPT-11 inhibit growth of primary and metastatic lung cancers in mice

Co-treatment with therapeutic neural stem cells expressing carboxyl esterase and CPT-11 inhibit growth of primary and metastatic lung cancers in mice

https://doi.org/10.18632/oncotarget.2547

Bo-Rim Yi, Seung U. Kim,  and Kyung-Chul Choi
12835-12848
Abstract  |  PDF  |  HTML  |  Order a Reprint

Inhibition of spontaneous and experimental lung metastasis of soft-tissue sarcoma by tumor-targeting Salmonella typhimurium A1-R

Inhibition of spontaneous and experimental lung metastasis of soft-tissue sarcoma by tumor-targeting Salmonella typhimurium A1-R

https://doi.org/10.18632/oncotarget.2561

Shinji Miwa, Yong Zhang, Kyung-Eun Baek, Fuminari Uehara, Shuya Yano, Mako Yamamoto, Yukihiko Hiroshima, Yasunori Matsumoto, Hiroaki Kimura, Katsuhiro Hayashi, Norio Yamamoto, Michael Bouvet, Hiroyuki Tsuchiya, Robert M. Hoffman,  and Ming Zhao
12849-12861
Abstract  |  PDF  |  HTML  |  Order a Reprint

VER-246608, a novel pan-isoform ATP competitive inhibitor of pyruvate dehydrogenase kinase, disrupts Warburg metabolism and induces context-dependent cytostasis in cancer cells

VER-246608, a novel pan-isoform ATP competitive inhibitor of pyruvate dehydrogenase kinase, disrupts Warburg metabolism and induces context-dependent cytostasis in cancer cells

https://doi.org/10.18632/oncotarget.2656

Jonathan D. Moore, Anna Staniszewska, Terence Shaw, Jalanie D’Alessandro, Ben Davis, Alan Surgenor, Lisa Baker, Natalia Matassova, James Murray, Alba Macias, Paul Brough, Mike Wood,  and Patrick C. Mahon
12862-12876
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Metformin and salinomycin as the best combination for the eradication of NSCLC monolayer cells and their alveospheres (cancer stem cells) irrespective of EGFR, KRAS, EML4/ALK and LKB1 status

Metformin and salinomycin as the best combination for the eradication of NSCLC monolayer cells and their alveospheres (cancer stem cells) irrespective of EGFR, KRAS, EML4/ALK and LKB1 status

https://doi.org/10.18632/oncotarget.2657

Zhiguang Xiao, Bianca Sperl, Axel Ullrich,  and Pjotr Knyazev
12877-12890
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Anti-proliferative and gene expression actions of resveratrol in breast cancer cells in vitro

Anti-proliferative and gene expression actions of resveratrol in breast cancer cells in vitro

https://doi.org/10.18632/oncotarget.2632

Yu-Tang Chin, Meng-Ti Hsieh, Sheng-Huei Yang, Po-Wei Tsai, Shwu-Huey Wang, Ching-Chiung Wang, Yee-Shin Lee, Guei-Yun Cheng, Wei-Chun HuangFu, David London, Heng-Yuan Tang, Earl Fu, Yun Yen, Leroy F. Liu, Hung-Yun Lin,  and Paul J. Davis
12891-12907
Abstract  |  PDF  |  HTML  |  Order a Reprint

MicroRNA expression patterns in the malignant progression of gliomas and a 5-microRNA signature for prognosis

MicroRNA expression patterns in the malignant progression of gliomas and a 5-microRNA signature for prognosis

https://doi.org/10.18632/oncotarget.2679

Wei Yan, Rui Li, Yanwei Liu, Pei Yang, Zheng Wang, Chuanbao Zhang, Zhaoshi Bao, Wei Zhang, Yongping You,  and Tao Jiang
12908-12915
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Aurora-A promotes chemoresistance in hepatocelluar carcinoma by targeting NF-kappaB/microRNA-21/PTEN signaling pathway

Aurora-A promotes chemoresistance in hepatocelluar carcinoma by targeting NF-kappaB/microRNA-21/PTEN signaling pathway

https://doi.org/10.18632/oncotarget.2682

Kai Zhang, Jing Chen, Dongqin Chen, Jiayuan Huang, Bing Feng, Siqi Han, Yitian Chen, Haizhu Song, Wei De, Ziman Zhu, Rui Wang,  and Longbang Chen
12916-12935
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Involvement of metformin and AMPK in the radioresponse and prognosis of luminal versus basal-like breast cancer treated with radiotherapy

Involvement of metformin and AMPK in the radioresponse and prognosis of luminal versus basal-like breast cancer treated with radiotherapy

https://doi.org/10.18632/oncotarget.2683

Yimin Zhang, Sarah J. Storr, Kerstie Johnson, Andrew R. Green, Emad A. Rakha, Ian O. Ellis, David A.L. Morgan,  and Stewart G. Martin
12936-12949
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

LIGHT/TNFSF14 increases osteoclastogenesis and decreases osteoblastogenesis in multiple myeloma-bone disease

LIGHT/TNFSF14 increases osteoclastogenesis and decreases osteoblastogenesis in multiple myeloma-bone disease

https://doi.org/10.18632/oncotarget.2633

Giacomina Brunetti, Rita Rizzi, Angela Oranger, Isabella Gigante, Giorgio Mori, Grazia Taurino, Teresa Mongelli, Graziana Colaianni, Adriana Di Benedetto, Roberto Tamma, Giuseppe Ingravallo, Anna Napoli, Maria Felicia Faienza, Anna Mestice, Paola Curci, Giorgina Specchia, Silvia Colucci,  and Maria Grano
12950-12967
Abstract  |  PDF  |  HTML  |  Order a Reprint

Clinical Research Papers

Peripheral primitive neuroectodermal tumor: Dynamic CT, MRI and clinicopathological characteristics - analysis of 36 cases and review of the literature

Peripheral primitive neuroectodermal tumor: Dynamic CT, MRI and clinicopathological characteristics - analysis of 36 cases and review of the literature

https://doi.org/10.18632/oncotarget.2649

Yan Tan, Hui Zhang, Guo-lin Ma, En-hua Xiao,  and Xiao-chun Wang
12968-12977
Abstract  |  PDF  |  HTML  |  Order a Reprint

Prognostic impact of a compartment-specific angiogenic marker profile in patients with pancreatic cancer

Prognostic impact of a compartment-specific angiogenic marker profile in patients with pancreatic cancer

https://doi.org/10.18632/oncotarget.2651

Christoph Kahlert, Maria Fiala, Gabriel Musso, Niels Halama, Sophia Keim, Massimiliano Mazzone, Felix Lasitschka, Mathieu Pecqueux, Fee Klupp, Thomas Schmidt, Nuh Rahbari, Sebastian Schölch, Christian Pilarsky, Alexis Ulrich, Martin Schneider, Juergen Weitz,  and Moritz Koch
12978-12989
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint


Copyright © 2017 Impact Journals
Impact Journals is a registered trademark of Impact Journals, LLC