Oncotarget

Vol 5, No 21

November 15, 2014

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DCE-MRI analysis of nasopharyngeal carcinoma, see  Falchook et al.

Table of Contents

Reviews

Overcoming resistance to BRAF inhibition in BRAF-mutated metastatic melanoma

Overcoming resistance to BRAF inhibition in BRAF-mutated metastatic melanoma

https://doi.org/10.18632/oncotarget.2602

Francesco Spagnolo, Paola Ghiorzo,  and Paola Queirolo
10206-10221
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Regulation of ERBB3/HER3 signaling in cancer

Regulation of ERBB3/HER3 signaling in cancer

https://doi.org/10.18632/oncotarget.2655

Kalpana Mujoo, Byung-Kwon Choi, Zhao Huang, Ningyan Zhang,  and Zhiqiang An
10222-10236
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Priority Research Papers

Preclinical efficacy of sepantronium bromide (YM155) in multiple myeloma is conferred by down regulation of Mcl-1

Preclinical efficacy of sepantronium bromide (YM155) in multiple myeloma is conferred by down regulation of Mcl-1

https://doi.org/10.18632/oncotarget.2529

Verena Wagner, Dirk Hose, Anja Seckinger, Ludmila Weiz, Tobias Meißner, Thiery Rème, Iris Breitkreutz, Klaus Podar, Anthony D. Ho, Hartmut Goldschmidt, Alwin Krämer, Bernard Klein,  and Marc S. Raab
10237-10250
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Inhibition of RAC1 GTPase sensitizes pancreatic cancer cells to γ-irradiation

Inhibition of RAC1 GTPase sensitizes pancreatic cancer cells to γ-irradiation

https://doi.org/10.18632/oncotarget.2500

Ying Yan, Ashley L. Hein, Asserewou Etekpo, Katrina M. Burchett, Chi Lin, Charles A. Enke, Surinder K. Batra, Kenneth H. Cowan,  and Michel M. Ouellette
10251-10270
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Clinical Research Papers

High KIF18A expression correlates with unfavorable prognosis in primary hepatocellular carcinoma

High KIF18A expression correlates with unfavorable prognosis in primary hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.2082

Weijia Liao, Guojin Huang, Yan Liao, Jianjun Yang, Qian Chen, ShengJun Xiao, Junfei Jin, Songqing He,  and Changming Wang
10271-10279
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Targeting hypoxia-inducible factor-1α (HIF-1α) in combination with antiangiogenic therapy: A phase I trial of bortezomib plus bevacizumab

Targeting hypoxia-inducible factor-1α (HIF-1α) in combination with antiangiogenic therapy: A phase I trial of bortezomib plus bevacizumab

https://doi.org/10.18632/oncotarget.2163

Gerald S. Falchook, Jennifer J. Wheler, Aung Naing, Edward F. Jackson, Filip Janku, David Hong, Chaan S. Ng, Nizar M. Tannir, Kristie N. Lawhorn, Mei Huang, Laura S. Angelo, Deeksha Vishwamitra, Kenneth Hess, Adrienne N. Howard, Kristin L. Parkhurst, Hesham M. Amin,  and Razelle Kurzrock
10280-10292
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

CAMK2N1 inhibits prostate cancer progression through androgen receptor-dependent signaling

CAMK2N1 inhibits prostate cancer progression through androgen receptor-dependent signaling

https://doi.org/10.18632/oncotarget.2511

Tao Wang, Shuiming Guo, Zhuo Liu, Licheng Wu, Mingchao Li, Jun Yang, Ruibao Chen, Xiaming Liu, Hua Xu, Shaoxin Cai, Hui Chen, Weiyong Li, Shaohua Xu, Liang Wang, Zhiquan Hu, Qianyuan Zhuang, Liping Wang, Kongming Wu, Jihong Liu, Zhangqun Ye, Jun-Yuan Ji, Chenguang Wang,  and Ke Chen
10293-10306
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Overexpression of platelet-derived growth factor receptor alpha promotes tumor progression and indicates poor prognosis in hepatocellular carcinoma

Overexpression of platelet-derived growth factor receptor alpha promotes tumor progression and indicates poor prognosis in hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.2537

Tao Wei, Li-Na Zhang, Yi Lv, Xiao-Ya Ma, Lei Zhi, Chang Liu, Feng Ma,  and Xu-Feng Zhang
10307-10317
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Research Papers

Specific genomic and transcriptomic aberrations in tumors induced by partial hepatectomy of a chronically inflamed murine liver

Specific genomic and transcriptomic aberrations in tumors induced by partial hepatectomy of a chronically inflamed murine liver

https://doi.org/10.18632/oncotarget.2515

Ezra Ella, Denise Heim, Evgeniy Stoyanov, Rona Harari-Steinfeld, Israel Steinfeld, Orit Pappo, Temima Schnitzer Perlman, Natalie Nachmansson, Ludmila Rivkin, Devorah Olam, Rinat Abramovitch, Henning Wege, Eithan Galun,  and Daniel Goldenberg
10318-10331
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The antitumor potential of Interleukin-27 in prostate cancer

The antitumor potential of Interleukin-27 in prostate cancer

https://doi.org/10.18632/oncotarget.1425

Emma Di Carlo, Carlo Sorrentino, Alessia Zorzoli, Serena Di Meo, Maria Grazia Tupone, Emanuela Ognio, Gabriella Mincione,  and Irma Airoldi
10332-10341
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Pharmacologic down-regulation of EZH2 suppresses bladder cancer in vitro and in vivo

Pharmacologic down-regulation of EZH2 suppresses bladder cancer in vitro and in vivo

https://doi.org/10.18632/oncotarget.1867

Shou-Hung Tang, Hsu-Shan Huang, Hong-Ui Wu, Yi-Ta Tsai, Mei-Jen Chuang, Cheng-Ping Yu, Shih-Ming Huang, Guang-Huan Sun, Sun-Yran Chang, Pei-Wen Hsiao, Dah-Shyong Yu,  and Tai-Lung Cha
10342-10355
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Poly(ADP-ribosyl)ation is involved in the epigenetic control of TET1 gene transcription

Poly(ADP-ribosyl)ation is involved in the epigenetic control of TET1 gene transcription

https://doi.org/10.18632/oncotarget.1905

Fabio Ciccarone, Elisabetta Valentini, Maria Giulia Bacalini, Michele Zampieri, Roberta Calabrese, Tiziana Guastafierro, Germano Mariano, Anna Reale, Claudio Franceschi,  and Paola Caiafa
10356-10367
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Failure of anti tumor-derived endothelial cell immunotherapy depends on augmentation of tumor hypoxia

Failure of anti tumor-derived endothelial cell immunotherapy depends on augmentation of tumor hypoxia

https://doi.org/10.18632/oncotarget.2015

Annalisa Pezzolo, Danilo Marimpietri, Lizzia Raffaghello, Claudia Cocco, Angela Pistorio, Claudio Gambini, Michele Cilli, Alberto Horenstein, Fabio Malavasi,  and Vito Pistoia
10368-10381
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p53 status as effect modifier of the association between pre-treatment fasting glucose and breast cancer outcomes in non diabetic, HER2 positive patients treated with trastuzumab

p53 status as effect modifier of the association between pre-treatment fasting glucose and breast cancer outcomes in non diabetic, HER2 positive patients treated with trastuzumab

https://doi.org/10.18632/oncotarget.2060

Patrizia Vici, Francesca Sperati, Marcello Maugeri-Saccà, Elisa Melucci, Anna Di Benedetto, Luigi Di Lauro, Laura Pizzuti, Domenico Sergi, Irene Terrenato, Luca Esposito, Carmelina Antonella Iannuzzi, Raffaella Pasquale, Claudio Botti, Barbara Fuhrman, Antonio Giordano, Marcella Mottolese,  and Maddalena Barba
10382-10392
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Notch signaling drives multiple myeloma induced osteoclastogenesis

Notch signaling drives multiple myeloma induced osteoclastogenesis

https://doi.org/10.18632/oncotarget.2084

Michela Colombo, Katja Thümmler, Leonardo Mirandola, Silvia Garavelli, Katia Todoerti, Luana Apicella, Elisa Lazzari, Marialuigia Lancellotti, Natalia Platonova, Moeed Akbar, Maurizio Chiriva-Internati, Richard Soutar, Antonino Neri, Carl S. Goodyear,  and Raffaella Chiaramonte
10393-10406
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Antitumor activity of S116836, a novel tyrosine kinase inhibitor, against imatinib-resistant FIP1L1-PDGFRα-expressing cells

Antitumor activity of S116836, a novel tyrosine kinase inhibitor, against imatinib-resistant FIP1L1-PDGFRα-expressing cells

https://doi.org/10.18632/oncotarget.2090

Yingying Shen, Xiaomei Ren, Ke Ding, Zhang Zhang, Deping Wang,  and Jingxuan Pan
10407-10420
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

H2AK119Ub1 and H3K27Me3 in molecular staging for survival prediction of patients with pancreatic ductal adenocarcinoma

H2AK119Ub1 and H3K27Me3 in molecular staging for survival prediction of patients with pancreatic ductal adenocarcinoma

https://doi.org/10.18632/oncotarget.2126

Shi Chen, Jiangzhi Chen, Qian Zhan, Yi Zhu, Hao Chen, Xiaxing Deng, Zhaoyuan Hou, Baiyong Shen, Yanling Chen,  and Chenghong Peng
10421-10433
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Mer590, a novel monoclonal antibody targeting MER receptor tyrosine kinase, decreases colony formation and increases chemosensitivity in non-small cell lung cancer

Mer590, a novel monoclonal antibody targeting MER receptor tyrosine kinase, decreases colony formation and increases chemosensitivity in non-small cell lung cancer

https://doi.org/10.18632/oncotarget.2142

Christopher T. Cummings, Rachel M.A. Linger, Rebecca A. Cohen, Susan Sather, Gregory D. Kirkpatrick, Kurtis D. Davies, Deborah DeRyckere, H. Shelton Earp,  and Douglas K. Graham
10434-10445
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Medical treatment of orthotopic glioblastoma with transferrin-conjugated nanoparticles encapsulating zoledronic acid

Medical treatment of orthotopic glioblastoma with transferrin-conjugated nanoparticles encapsulating zoledronic acid

https://doi.org/10.18632/oncotarget.2182

Manuela Porru, Silvia Zappavigna, Giuseppina Salzano, Amalia Luce, Antonella Stoppacciaro, Maria Luisa Balestrieri, Simona Artuso, Sara Lusa, Giuseppe De Rosa, Carlo Leonetti,  and Michele Caraglia
10446-10459
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Efficacy of dual PI-3K and mTOR inhibitors in vitro and in vivo in acute lymphoblastic leukemia

Efficacy of dual PI-3K and mTOR inhibitors in vitro and in vivo in acute lymphoblastic leukemia

https://doi.org/10.18632/oncotarget.2260

Jacky Wong, Robert Welschinger, John Hewson, Kenneth . F Bradstock,  and Linda J. Bendall
10460-10472
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Thymidine phosphorylase activates NFκB and stimulates the expression of angiogenic and metastatic factors in human cancer cells

Thymidine phosphorylase activates NFκB and stimulates the expression of angiogenic and metastatic factors in human cancer cells

https://doi.org/10.18632/oncotarget.2242

Sho Tabata, Ryuji Ikeda, Masatatsu Yamamoto, Shunji Shimaoka, Naofumi Mukaida, Yasuo Takeda, Katsushi Yamada, Tomoyoshi Soga, Tatsuhiko Furukawa,  and Shin-ichi Akiyama
10473-10485
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Nicotinic acetylcholine receptors induce c-Kit ligand/Stem Cell Factor and promote stemness in an ARRB1/ β-arrestin-1 dependent manner in NSCLC

Nicotinic acetylcholine receptors induce c-Kit ligand/Stem Cell Factor and promote stemness in an ARRB1/ β-arrestin-1 dependent manner in NSCLC

https://doi.org/10.18632/oncotarget.2395

Deepak Perumal, Smitha Pillai, Jonathan Nguyen, Courtney Schaal, Domenico Coppola,  and Srikumar P. Chellappan
10486-10502
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Metformin and erlotinib synergize to inhibit basal breast cancer

Metformin and erlotinib synergize to inhibit basal breast cancer

https://doi.org/10.18632/oncotarget.2391

Ying-Ka Ingar Lau, Xing Du, Vinayak Rayannavar, Benjamin Hopkins, Jacquelyn Shaw, Eliana Bessler, Tiffany Thomas, Maira M. Pires, Megan Keniry, Ramon E. Parsons, Serge Cremers, Matthias Szabolcs,  and Matthew A. Maurer
10503-10517
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

RNA-seq analysis reveals significant effects of EGFR signalling on the secretome of mesenchymal stem cells

RNA-seq analysis reveals significant effects of EGFR signalling on the secretome of mesenchymal stem cells

https://doi.org/10.18632/oncotarget.2420

Antonella De Luca, Cristin Roma, Marianna Gallo, Francesca Fenizia, Francesca Bergantino, Daniela Frezzetti, Susan Costantini,  and Nicola Normanno
10518-10528
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

AngioMatrix, a signature of the tumor angiogenic switch-specific matrisome, correlates with poor prognosis for glioma and colorectal cancer patients

AngioMatrix, a signature of the tumor angiogenic switch-specific matrisome, correlates with poor prognosis for glioma and colorectal cancer patients

https://doi.org/10.18632/oncotarget.2470

Benoit Langlois, Falk Saupe, Tristan Rupp, Christiane Arnold, Michaël Van der Heyden, Gertraud Orend,  and Thomas Hussenet
10529-10545
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Pharmacological targeting the ATR–CHK1–WEE1 axis involves balancing cell growth stimulation and apoptosis

Pharmacological targeting the ATR–CHK1–WEE1 axis involves balancing cell growth stimulation and apoptosis

https://doi.org/10.18632/oncotarget.2508

Joyce P.Y. Mak, Wing Yu Man, Hoi Tang Ma,  and Randy Y.C. Poon
10546-10557
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

De-acetylation and degradation of HSPA5 is critical for E1A metastasis suppression in breast cancer cells

De-acetylation and degradation of HSPA5 is critical for E1A metastasis suppression in breast cancer cells

https://doi.org/10.18632/oncotarget.2510

Yi-Wen Chang, Hsin-An Chen, Chi-Feng Tseng, Chih-Chen Hong, Jui-Ti Ma, Mien-Chie Hung, Chih-Hsiung Wu, Ming-Te Huang,  and Jen-Liang Su
10558-10570
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

SOX10, a novel HMG-box-containing tumor suppressor, inhibits growth and metastasis of digestive cancers by suppressing the Wnt/β-catenin pathway

SOX10, a novel HMG-box-containing tumor suppressor, inhibits growth and metastasis of digestive cancers by suppressing the Wnt/β-catenin pathway

https://doi.org/10.18632/oncotarget.2512

Xin Tong, Lili Li, Xiaoyan Li, Lei Heng, Lan Zhong, Xianwei Su, Rong Rong, Shi Hu, Wenjia Liu, Baoqing Jia, Xing Liu, Geng Kou, Jun Han, Shangjing Guo, Yi Hu, Cheng Li, Qian Tao,  and Yajun Guo
10571-10583
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Androgen receptor promotes gastric cancer cell migration and invasion via AKT-phosphorylation dependent upregulation of matrix metalloproteinase 9

Androgen receptor promotes gastric cancer cell migration and invasion via AKT-phosphorylation dependent upregulation of matrix metalloproteinase 9

https://doi.org/10.18632/oncotarget.2513

Bao-gui Zhang, Tao Du, Ming-de Zang, Qing Chang, Zhi-yuan Fan, Jian-fang Li, Bei-qin Yu, Li-ping Su, Chen Li, Chao Yan, Qin-long Gu, Zheng-gang Zhu, Min Yan,  and Bingya Liu
10584-10595
Abstract  |  PDF  |  HTML  |  Order a Reprint

Angiomatous meningiomas have a distinct genetic profile with multiple chromosomal polysomies including polysomy of chromosome 5

Angiomatous meningiomas have a distinct genetic profile with multiple chromosomal polysomies including polysomy of chromosome 5

https://doi.org/10.18632/oncotarget.2517

Malak S. Abedalthagafi, Parker H. Merrill, Wenya Linda Bi, Robert T. Jones, Marc L. Listewnik, Shakti H. Ramkissoon, Aaron R. Thorner, Ian F. Dunn, Rameen Beroukhim, Brian M. Alexander, Priscilla K. Brastianos, Joshua M. Francis, Rebecca D. Folkerth, Keith L. Ligon, Paul Van Hummelen, Azra H. Ligon,  and Sandro Santagata
10596-10606
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Suppression of p53 by Notch3 is mediated by Cyclin G1 and sustained by MDM2 and miR-221 axis in hepatocellular carcinoma

Suppression of p53 by Notch3 is mediated by Cyclin G1 and sustained by MDM2 and miR-221 axis in hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.2523

Catia Giovannini, Manuela Minguzzi, Michele Baglioni, Francesca Fornari, Ferdinando Giannone, Matteo Ravaioli, Matteo Cescon, Pasquale Chieco, Luigi Bolondi,  and Laura Gramantieri
10607-10620
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Inhibitory effects of transcription factor Ikaros on the expression of liver cancer stem cell marker CD133 in hepatocellular carcinoma

Inhibitory effects of transcription factor Ikaros on the expression of liver cancer stem cell marker CD133 in hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.2524

Lin Zhang, Hong Li, Chao Ge, Meng Li, Fang-yu Zhao, He-lei Hou, Miao-xin Zhu, Hua Tian, Li-xing Zhang, Tao-yang Chen, Guo-ping Jiang, Hai-yang Xie, Ying Cui, Ming Yao,  and Jin-jun Li
10621-10635
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Down-regulation of miRNA-106b inhibits growth of melanoma cells by promoting G1-phase cell cycle arrest and reactivation of p21/WAF1/Cip1 protein

Down-regulation of miRNA-106b inhibits growth of melanoma cells by promoting G1-phase cell cycle arrest and reactivation of p21/WAF1/Cip1 protein

https://doi.org/10.18632/oncotarget.2527

Ram Prasad,  and Santosh K. Katiyar
10636-10649
Abstract  |  PDF  |  HTML  |  Order a Reprint

Regulation of NADPH-dependent Nitric Oxide and reactive oxygen species signalling in endothelial and melanoma cells by a photoactive NADPH analogue

Regulation of NADPH-dependent Nitric Oxide and reactive oxygen species signalling in endothelial and melanoma cells by a photoactive NADPH analogue

https://doi.org/10.18632/oncotarget.2525

Florian Rouaud, Miguel Romero-Perez, Huan Wang, Irina Lobysheva, Booma Ramassamy, Etienne Henry, Patrick Tauc, Damien Giacchero, Jean-Luc Boucher, Eric Deprez, Stéphane Rocchi,  and Anny Slama-Schwok
10650-10664
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Inhibition of histone H3K79 methylation selectively inhibits proliferation, self-renewal and metastatic potential of breast cancer

Inhibition of histone H3K79 methylation selectively inhibits proliferation, self-renewal and metastatic potential of breast cancer

https://doi.org/10.18632/oncotarget.2496

Li Zhang, Lisheng Deng, Fengju Chen, Yuan Yao, Bulan Wu, Liping Wei, Qianxing Mo,  and Yongcheng Song
10665-10677
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The induction of the p53 tumor suppressor protein bridges the apoptotic and autophagic signaling pathways to regulate cell death in prostate cancer cells

The induction of the p53 tumor suppressor protein bridges the apoptotic and autophagic signaling pathways to regulate cell death in prostate cancer cells

https://doi.org/10.18632/oncotarget.2528

Lymor Ringer, Paul Sirajuddin, Lucas Tricoli, Sarah Waye, Muhammad Umer Choudhry, Erika Parasido, Angiela Sivakumar, Mary Heckler, Aisha Naeem, Iman Abdelgawad, Xuefeng Liu, Adam S. Feldman, Richard J. Lee, Chin-Lee Wu, Venkata Yenugonda, Bhaskar Kallakury, Anatoly Dritschilo, John Lynch, Richard Schlegel, Olga Rodriguez, Richard G. Pestell, Maria Laura Avantaggiati,  and Chris Albanese
10678-10691
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Potential therapeutic effect of the secretome from human uterine cervical stem cells against both cancer and stromal cells compared with adipose tissue stem cells

Potential therapeutic effect of the secretome from human uterine cervical stem cells against both cancer and stromal cells compared with adipose tissue stem cells

https://doi.org/10.18632/oncotarget.2530

Noemí Eiró, Juan Sendon-Lago, Samuel Seoane, María A. Bermúdez, Maria Luz Lamelas, Tomás Garcia-Caballero, José Schneider, Roman Perez-Fernandez,  and Francisco J. Vizoso
10692-10708
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Regulation of the viability of Nf1 deficient cells by PKC isoforms

Regulation of the viability of Nf1 deficient cells by PKC isoforms

https://doi.org/10.18632/oncotarget.2531

Xiaodong Zhou, Ling Shen, Toshima Parris, Junchi Huang, Bo Yi, Khalil Helou,  and Changyan Chen
10709-10717
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CCL5 promotes VEGF-dependent angiogenesis by down-regulating miR-200b through PI3K/Akt signaling pathway in human chondrosarcoma cells

CCL5 promotes VEGF-dependent angiogenesis by down-regulating miR-200b through PI3K/Akt signaling pathway in human chondrosarcoma cells

https://doi.org/10.18632/oncotarget.2532

Guan-Ting Liu, Hsien-Te Chen, Hsi-Kai Tsou, Tzu-Wei Tan, Yi-Chin Fong, Po-Chen Chen, Wei-Hung Yang, Shih-Wei Wang, Jui-Chieh Chen,  and Chih-Hsin Tang
10718-10731
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Simultaneous targeting of PI3Kδ and a PI3Kδ-dependent MEK1/2-Erk1/2 pathway for therapy in pediatric B-cell acute lymphoblastic leukemia

Simultaneous targeting of PI3Kδ and a PI3Kδ-dependent MEK1/2-Erk1/2 pathway for therapy in pediatric B-cell acute lymphoblastic leukemia

https://doi.org/10.18632/oncotarget.2533

Xiang Wang, Xi Zhang, Ben-shang Li, Xiaowen Zhai, Zhuo Yang, Li-xia Ding, Hongsheng Wang, Chris Liang, Weiliang Zhu, Jian Ding,  and Ling-hua Meng
10732-10744
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Resveratrol potentiates the in vitro and in vivo anti-tumoral effects of curcumin in head and neck carcinomas

Resveratrol potentiates the in vitro and in vivo anti-tumoral effects of curcumin in head and neck carcinomas

https://doi.org/10.18632/oncotarget.2534

Laura Masuelli, Enrica Di Stefano, Massimo Fantini, Rosanna Mattera, Monica Benvenuto, Laura Marzocchella, Pamela Sacchetti, Chiara Focaccetti, Roberta Bernardini, Ilaria Tresoldi, Valerio Izzi, Maurizio Mattei, Giovanni Vanni Frajese, Florigio Lista, Andrea Modesti,  and Roberto Bei
10745-10762
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Fas signaling promotes chemoresistance in gastrointestinal cancer by up-regulating P-glycoprotein

Fas signaling promotes chemoresistance in gastrointestinal cancer by up-regulating P-glycoprotein

https://doi.org/10.18632/oncotarget.2498

Haoxuan Zheng, Zhizhong Liu, Tao Liu, Yidong Cai, Yadong Wang, Shiyong Lin, Jinmin Chen, Jing Wang, Zhiqing Wang,  and Bo Jiang
10763-10777
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Paradoxical role of CBX8 in proliferation and metastasis of colorectal cancer

Paradoxical role of CBX8 in proliferation and metastasis of colorectal cancer

https://doi.org/10.18632/oncotarget.2502

Jianjun Tang, Gang Wang, Meifang Zhang, Feng-yan Li, Yi Sang, Boqing Wang, Kaishun Hu, Yuanzhong Wu, Rongzhen Luo, Dan Liao, Jingying Cao, Xin Wang, Li Wang, Ruhua Zhang, Xiaoshi Zhang, Wu-Guo Deng, Dan Xie, Rui-hua Xu,  and Tiebang Kang
10778-10790
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Induction of a specific CD8+ T-cell response to cancer/testis antigens by demethylating pre-treatment against osteosarcoma

Induction of a specific CD8+ T-cell response to cancer/testis antigens by demethylating pre-treatment against osteosarcoma

https://doi.org/10.18632/oncotarget.2505

Binghao Li, Xiaobing Zhu, Lingling Sun, Li Yuan, Jian Zhang, Hengyuan Li,  and Zhaoming Ye
10791-10802
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Oct-4 and nanog promote the epithelial-mesenchymal transition of breast cancer stem cells and are associated with poor prognosis in breast cancer patients

Oct-4 and nanog promote the epithelial-mesenchymal transition of breast cancer stem cells and are associated with poor prognosis in breast cancer patients

https://doi.org/10.18632/oncotarget.2506

Dan Wang, Ping Lu, Hao Zhang, Minna Luo, Xin Zhang, Xiaofei Wei, Jiyue Gao, Zuowei Zhao,  and Caigang Liu
10803-10815
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miR-145 inhibits tumor growth and metastasis by targeting metadherin in high-grade serous ovarian carcinoma

miR-145 inhibits tumor growth and metastasis by targeting metadherin in high-grade serous ovarian carcinoma

https://doi.org/10.18632/oncotarget.2522

Ruifen Dong, Xiaolin Liu, Qing Zhang, Zhijun Jiang, Yingwei Li, Yuyan Wei, Yinuo Li, Qifeng Yang, Jinsong Liu, Jian-Jun Wei, Changshun Shao, Zhaojian Liu,  and Beihua Kong
10816-10829
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A novel drug discovery strategy: Mechanistic investigation of an enantiomeric antitumor agent targeting dual p53 and NF-κB pathways

A novel drug discovery strategy: Mechanistic investigation of an enantiomeric antitumor agent targeting dual p53 and NF-κB pathways

https://doi.org/10.18632/oncotarget.2521

Chunlin Zhuang, Chunquan Sheng, Woo Shik Shin, Yuelin Wu, Jin Li, Jianzhong Yao, Guoqiang Dong, Wen Zhang, Yuk Yin Sham, Zhenyuan Miao,  and Wannian Zhang
10830-10839
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CDKL2 promotes epithelial-mesenchymal transition and breast cancer progression

CDKL2 promotes epithelial-mesenchymal transition and breast cancer progression

https://doi.org/10.18632/oncotarget.2535

Linna Li, Chunping Liu, Robert J. Amato, Jeffrey T. Chang, Wenliang Li,  and Wenliang Li
10840-10853
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Stromal TGF-β signaling induces AR activation in prostate cancer

Stromal TGF-β signaling induces AR activation in prostate cancer

https://doi.org/10.18632/oncotarget.2536

Feng Yang, Yizhen Chen, Tao Shen, Dan Guo, Olga Dakhova, Michael M. Ittmann, Chad J. Creighton, Yiqun Zhang, Truong D. Dang,  and David R. Rowley
10854-10869
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Msi1 promotes tumor growth and cell proliferation by targeting cell cycle checkpoint proteins p21, p27 and p53 in cervical carcinomas

Msi1 promotes tumor growth and cell proliferation by targeting cell cycle checkpoint proteins p21, p27 and p53 in cervical carcinomas

https://doi.org/10.18632/oncotarget.2539

Xian Liu, Wen-Ting Yang,  and Peng-Sheng Zheng
10870-10885
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The ubiquitin E3 ligase ITCH enhances breast tumor progression by inhibiting the Hippo tumor suppressor pathway

The ubiquitin E3 ligase ITCH enhances breast tumor progression by inhibiting the Hippo tumor suppressor pathway

https://doi.org/10.18632/oncotarget.2540

Zaidoun Salah, Ella Itzhaki,  and Rami I. Aqeilan
10886-10900
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Downregulation of BRCA1-BRCA2-containing complex subunit 3 sensitizes glioma cells to temozolomide

Downregulation of BRCA1-BRCA2-containing complex subunit 3 sensitizes glioma cells to temozolomide

https://doi.org/10.18632/oncotarget.2543

Kit Man Chai, Chih-Yen Wang, Hung-Jiun Liaw, Kuan-Min Fang, Chung-Shi Yang,  and Shun-Fen Tzeng
10901-10915
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Angiostatic, tumor inflammatory and anti-tumor effects of CXCL447-70 and CXCL4L147-70 in an EGF-dependent breast cancer model

Angiostatic, tumor inflammatory and anti-tumor effects of CXCL447-70 and CXCL4L147-70 in an EGF-dependent breast cancer model

https://doi.org/10.18632/oncotarget.2538

Katrien Van Raemdonck, Nele Berghmans, Vincent Vanheule, Antonella Bugatti, Paul Proost, Ghislain Opdenakker, Marco Presta, Jo Van Damme,  and Sofie Struyf
10916-10933
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Proscillaridin A is cytotoxic for glioblastoma cell lines and controls tumor xenograft growth in vivo

Proscillaridin A is cytotoxic for glioblastoma cell lines and controls tumor xenograft growth in vivo

https://doi.org/10.18632/oncotarget.2541

Emilie Denicolaï, Nathalie Baeza-Kallee, Aurélie Tchoghandjian, Manon Carré, Carole Colin, Carine Jiguet Jiglaire, Sandy Mercurio, Christophe Beclin,  and Dominique Figarella-Branger
10934-10948
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An NCR1-based chimeric receptor endows T-cells with multiple anti-tumor specificities

An NCR1-based chimeric receptor endows T-cells with multiple anti-tumor specificities

https://doi.org/10.18632/oncotarget.1919

Yair Tal, Shlomo Yaakobi, Miryam Horovitz-Fried, Einav Safyon, Benyamin Rosental, Angel Porgador,  and Cyrille J. Cohen
10949-10958
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