Oncotarget

Vol 5, No 20

October 30, 2014

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About The Cover

E2f1 and E2f3 inhibit tumorigenesis on a retinoblastoma-sensitized background. See Benavente et al.

Table of Contents

Editorial

Targeting IL-17 for pancreatic cancer prevention

Targeting IL-17 for pancreatic cancer prevention

https://doi.org/10.18632/oncotarget.2618

Florencia McAllister,  and Steven D. Leach
9530-9531
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Rethinking glioma treatment strategy

Rethinking glioma treatment strategy

https://doi.org/10.18632/oncotarget.2619

Tatsuya Ozawa,  and Eric C. Holland
9532-9533
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Reviews

How mRNA is misspliced in acute myelogenous leukemia (AML)?

How mRNA is misspliced in acute myelogenous leukemia (AML)?

https://doi.org/10.18632/oncotarget.2304

Aminetou Mint Mohamed, Morgan Thénoz, Françoise Solly, Marie Balsat, Franck Mortreux,  and Eric Wattel
9534-9545
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AXL kinase as a novel target for cancer therapy

AXL kinase as a novel target for cancer therapy

https://doi.org/10.18632/oncotarget.2542

Xiaoliang Wu, Xuewen Liu, Sanjay Koul, Chang Youl Lee, Zhenfeng Zhang,  and Balazs Halmos
9546-9563
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Inhibition of STAT5: A therapeutic option in BCR-ABL1-driven leukemia

Inhibition of STAT5: A therapeutic option in BCR-ABL1-driven leukemia

https://doi.org/10.18632/oncotarget.2465

Angelika Berger, Veronika Sexl, Peter Valent,  and Richard Moriggl
9564-9576
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Priority Research Papers

The nuclear import of ribosomal proteins is regulated by mTOR

The nuclear import of ribosomal proteins is regulated by mTOR

https://doi.org/10.18632/oncotarget.2473

Dubek Kazyken, Yelimbek Kaz, Vladimir Kiyan, Assylbek A. Zhylkibayev, Chien-Hung Chen, Nitin K. Agarwal,  and Dos D. Sarbassov
9577-9593
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Chromatin remodelers HELLS and UHRF1 mediate the epigenetic deregulation of genes that drive retinoblastoma tumor progression

Chromatin remodelers HELLS and UHRF1 mediate the epigenetic deregulation of genes that drive retinoblastoma tumor progression

https://doi.org/10.18632/oncotarget.2468

Claudia A. Benavente, David Finkelstein, Dianna A. Johnson, Jean-Christophe Marine, Ruth Ashery-Padan,  and Michael A. Dyer
9594-9608
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Clinical Research Papers

Melanoma patient-derived xenografts accurately model the disease and develop fast enough to guide treatment decisions

Melanoma patient-derived xenografts accurately model the disease and develop fast enough to guide treatment decisions

https://doi.org/10.18632/oncotarget.2445

Berglind O. Einarsdottir, Roger Olofsson Bagge, Joydeep Bhadury, Henrik Jespersen, Jan Mattsson, Lisa M. Nilsson, Katarina Truvé, Marcela Dávila López, Peter Naredi, Ola Nilsson, Ulrika Stierner, Lars Ny,  and Jonas A. Nilsson
9609-9618
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The Hippo transducer TAZ as a biomarker of pathological complete response in HER2-positive breast cancer patients treated with trastuzumab-based neoadjuvant therapy

The Hippo transducer TAZ as a biomarker of pathological complete response in HER2-positive breast cancer patients treated with trastuzumab-based neoadjuvant therapy

https://doi.org/10.18632/oncotarget.2449

Patrizia Vici, Marcella Mottolese, Laura Pizzuti, Maddalena Barba, Francesca Sperati, Irene Terrenato, Anna Di Benedetto, Clara Natoli, Teresa Gamucci, Domenico Angelucci, Maria Teresa Ramieri, Luigi Di Lauro, Domenico Sergi, Monica Bartucci, Rosanna Dattilo, Alfredo Pagliuca, Ruggero De Maria,  and Marcello Maugeri-Saccà
9619-9625
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Heterotrimeric G-protein alpha-12 (Gα12) subunit promotes oral cancer metastasis

Heterotrimeric G-protein alpha-12 (Gα12) subunit promotes oral cancer metastasis

https://doi.org/10.18632/oncotarget.2437

Chai Phei Gan, Vyomesh Patel, Constantinos M. Mikelis, Rosnah binti Zain, Alfredo A. Molinolo, Mannil Thomas Abraham, Soo-Hwang Teo, Zainal Ariff Abdul Rahman, J. Silvio Gutkind,  and Sok Ching Cheong
9626-9640
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Chemoradiation provides a physiological selective pressure that increases the expansion of aberrant TP53 tumor variants in residual rectal cancerous regions

Chemoradiation provides a physiological selective pressure that increases the expansion of aberrant TP53 tumor variants in residual rectal cancerous regions

https://doi.org/10.18632/oncotarget.2438

Kazuko Sakai, Shinsuke Kazama, Yuzo Nagai, Koji Murono, Toshiaki Tanaka, Soichiro Ishihara, Eiji Sunami, Shuta Tomida, Kazuto Nishio,  and Toshiaki Watanabe
9641-9649
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Increased serum levels of circulating exosomal microRNA-373 in receptor-negative breast cancer patients

Increased serum levels of circulating exosomal microRNA-373 in receptor-negative breast cancer patients

https://doi.org/10.18632/oncotarget.2520

Corinna Eichelser, Isabel Stückrath, Volkmar Müller, Karin Milde-Langosch, Harriet Wikman, Klaus Pantel,  and Heidi Schwarzenbach
9650-9663
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Research Papers

Tumor hypoxia enhances Non-Small Cell Lung Cancer metastasis by selectively promoting macrophage M2 polarization through the activation of ERK signaling

Tumor hypoxia enhances Non-Small Cell Lung Cancer metastasis by selectively promoting macrophage M2 polarization through the activation of ERK signaling

https://doi.org/10.18632/oncotarget.1856

Jun Zhang, Ji Cao, Shenglin Ma, Rong Dong, Wen Meng, Meidan Ying, Qinjie Weng, Zibo Chen, Jian Ma, Qingxia Fang, Qiaojun He,  and Bo Yang
9664-9677
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Expression of stemness genes in primary breast cancer tissues: the role of SOX2 as a prognostic marker for detection of early recurrence

Expression of stemness genes in primary breast cancer tissues: the role of SOX2 as a prognostic marker for detection of early recurrence

https://doi.org/10.18632/oncotarget.1936

Mauro Finicelli, Giovanni Benedetti, Tiziana Squillaro, Barbara Pistilli, Andrea Marcellusi, Paola Mariani, Alfredo Santinelli, Luciano Latini, Umberto Galderisi,  and Antonio Giordano
9678-9688
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Involvement of FoxQ1 in NSCLC through regulating EMT and increasing chemosensitivity

Involvement of FoxQ1 in NSCLC through regulating EMT and increasing chemosensitivity

https://doi.org/10.18632/oncotarget.2103

Jian Feng, Liqin Xu, Songshi Ni, Jun Gu, Huijun Zhu, Haiying Wang, Shu Zhang, Wei Zhang,  and Jianfei Huang
9689-9702
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SapC-DOPS-induced lysosomal cell death synergizes with TMZ in glioblastoma

SapC-DOPS-induced lysosomal cell death synergizes with TMZ in glioblastoma

https://doi.org/10.18632/oncotarget.2232

Jeffrey Wojton, Walter Hans Meisen, Naduparambil K. Jacob, Amy Haseley Thorne, Jayson Hardcastle, Nicholas Denton, Zhengtao Chu, Nina Dmitrieva, Rachel Marsh, Erwin G. Van Meir, Chang-Hyuk Kwon, Arnab Chakravarti, Xiaoyang Qi,  and Balveen Kaur
9703-9709
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Diacylglycerol kinase α promotes 3D cancer cell growth and limits drug sensitivity through functional interaction with Src

Diacylglycerol kinase α promotes 3D cancer cell growth and limits drug sensitivity through functional interaction with Src

https://doi.org/10.18632/oncotarget.2344

Pedro Torres-Ayuso, Manuel Daza-Martín, Jorge Martín-Pérez, Antonia Ávila-Flores,  and Isabel Mérida
9710-9726
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Cancer-derived immunoglobulin G promotes LPS-induced proinflammatory cytokine production via binding to TLR4 in cervical cancer cells

Cancer-derived immunoglobulin G promotes LPS-induced proinflammatory cytokine production via binding to TLR4 in cervical cancer cells

https://doi.org/10.18632/oncotarget.2359

Juping Wang, Danyi Lin, Hui Peng, Jimin Shao,  and Jiang Gu
9727-9743
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Caveolin-1 is down-regulated in alveolar rhabdomyosarcomas and negatively regulates tumor growth

Caveolin-1 is down-regulated in alveolar rhabdomyosarcomas and negatively regulates tumor growth

https://doi.org/10.18632/oncotarget.2403

Juan Huertas-Martínez, Santiago Rello-Varona, David Herrero-Martín, Ignasi Barrau, Silvia García-Monclús, Miguel Sáinz-Jaspeado, Laura Lagares-Tena, Yaiza Núñez-Álvarez, Silvia Mateo-Lozano, Jaume Mora, Josep Roma, Nuria Toran, Sebastian Moran, Roser López-Alemany, Soledad Gallego, Manel Esteller, Miguel A. Peinado, Xavier García del Muro,  and Oscar M. Tirado
9744-9755
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Amifostine alleviates radiation-induced lethal small bowel damage via promotion of 14-3-3σ-mediated nuclear p53 accumulation

Amifostine alleviates radiation-induced lethal small bowel damage via promotion of 14-3-3σ-mediated nuclear p53 accumulation

https://doi.org/10.18632/oncotarget.2386

Eng-Yen Huang, Feng-Sheng Wang, Yu-Min Chen, Yi-Fan Chen, Chung-Chi Wang, I-Hui Lin, Yu-Jie Huang,  and Kuender D. Yang
9756-9769
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Methylation of miR-155-3p in mantle cell lymphoma and other non-Hodgkin’s lymphomas

Methylation of miR-155-3p in mantle cell lymphoma and other non-Hodgkin’s lymphomas

https://doi.org/10.18632/oncotarget.2390

Rita Lh Yim, Kwan Yeung Wong, Yok Lam Kwong, Florence Loong, Chung Ying Leung, Raymond Chu, William W. Lam, Pak Kwan Hui, Raymond Lai,  and Chor Sang Chin
9770-9782
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Systematic dissection of the mechanisms underlying progesterone receptor downregulation in endometrial cancer

Systematic dissection of the mechanisms underlying progesterone receptor downregulation in endometrial cancer

https://doi.org/10.18632/oncotarget.2392

Shujie Yang, Yichen Jia, Xiaoyue Liu, Christopher Winters, Xinjun Wang, Yuping Zhang, Eric J. Devor, Adriann M. Hovey, Henry D. Reyes, Xue Xiao, Yang Xu, Donghai Dai, Xiangbing Meng, Kristina W. Thiel, Frederick E. Domann,  and Kimberly K. Leslie
9783-9797
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Hypermethylation of DAPK1 is an independent prognostic factor predicting survival in diffuse large B-cell lymphoma

Hypermethylation of DAPK1 is an independent prognostic factor predicting survival in diffuse large B-cell lymphoma

https://doi.org/10.18632/oncotarget.2394

Lasse Sommer Kristensen, Fazila Asmar, Konstantinos Dimopoulos, Mette Kathrine Nygaard, Derya Aslan, Jakob Werner Hansen, Elisabeth Ralfkiaer,  and Kirsten Grønbæk
9798-9810
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Combined VEGF and CXCR4 antagonism targets the GBM stem cell population and synergistically improves survival in an intracranial mouse model of glioblastoma

Combined VEGF and CXCR4 antagonism targets the GBM stem cell population and synergistically improves survival in an intracranial mouse model of glioblastoma

https://doi.org/10.18632/oncotarget.2443

Amy Barone, Rajarshi Sengupta, Nicole M. Warrington, Erin Smith, Patrick Y. Wen, Rolf A. Brekken, Barbara Romagnoli, Garry Douglas, Eric Chevalier, Michael P. Bauer, Klaus Dembowsky, David Piwnica-Worms,  and Joshua B. Rubin
9811-9822
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TM4SF4 overexpression in radiation-resistant lung carcinoma cells activates IGF1R via elevation of IGF1

TM4SF4 overexpression in radiation-resistant lung carcinoma cells activates IGF1R via elevation of IGF1

https://doi.org/10.18632/oncotarget.2450

Soo-Im Choi, Seo-Yeon Kim, Jaeha Lee, Eun-Wie Cho,  and In-Gyu Kim
9823-9837
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A novel action mechanism for MPT0G013, a derivative of arylsulfonamide, inhibits tumor angiogenesis through up-regulation of TIMP3 expression

A novel action mechanism for MPT0G013, a derivative of arylsulfonamide, inhibits tumor angiogenesis through up-regulation of TIMP3 expression

https://doi.org/10.18632/oncotarget.2451

Chih-Ya Wang, Jing-Ping Liou, An-Chi Tsai, Mei-Jung Lai, Yi-Min Liu, Hsueh-Yun Lee, Jing-Chi Wang, Shiow-Lin Pan,  and Che-Ming Teng
9838-9850
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Prevention of diabetes-promoted colorectal cancer by (n-3) polyunsaturated fatty acids and (n-3) PUFA mimetic

Prevention of diabetes-promoted colorectal cancer by (n-3) polyunsaturated fatty acids and (n-3) PUFA mimetic

https://doi.org/10.18632/oncotarget.2453

Anna Algamas-Dimantov, Einav Yehuda-Shnaidman, Rachel Hertz, Irena Peri, Jacob Bar-Tana,  and Betty Schwartz
9851-9863
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Comprehensive analysis of long non-coding RNAs in human breast cancer clinical subtypes

Comprehensive analysis of long non-coding RNAs in human breast cancer clinical subtypes

https://doi.org/10.18632/oncotarget.2454

Xiaoping Su, Gabriel G. Malouf, Yunxin Chen, Jianping Zhang, Hui Yao, Vicente Valero, John N. Weinstein, Jean-Philippe Spano, Funda Meric-Bernstam, David Khayat,  and Francisco J. Esteva
9864-9876
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Inhibition of SphK1 reduces radiation-induced migration and enhances sensitivity to cetuximab treatment by affecting the EGFR / SphK1 crosstalk

Inhibition of SphK1 reduces radiation-induced migration and enhances sensitivity to cetuximab treatment by affecting the EGFR / SphK1 crosstalk

https://doi.org/10.18632/oncotarget.2436

Carlotta Schiefler, Guido Piontek, Johannes Doescher, Dominik Schuettler, Martin Mißlbeck, Martina Rudelius, Anna Haug, Rudolf Reiter, Gero Brockhoff,  and Anja Pickhard
9877-9888
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Targeting the DNA replication checkpoint by pharmacologic inhibition of Chk1 kinase: a strategy to sensitize APC mutant colon cancer cells to 5-fluorouracil chemotherapy

Targeting the DNA replication checkpoint by pharmacologic inhibition of Chk1 kinase: a strategy to sensitize APC mutant colon cancer cells to 5-fluorouracil chemotherapy

https://doi.org/10.18632/oncotarget.2475

Estefania Martino-Echarri, Beric R. Henderson,  and Mariana G. Brocardo
9889-9900
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

RNA sequencing identifies specific PIWI-interacting small non-coding RNA expression patterns in breast cancer

RNA sequencing identifies specific PIWI-interacting small non-coding RNA expression patterns in breast cancer

https://doi.org/10.18632/oncotarget.2476

Adnan Hashim, Francesca Rizzo, Giovanna Marchese, Maria Ravo, Roberta Tarallo, Giovanni Nassa, Giorgio Giurato, Gianluca Santamaria, Angela Cordella, Concita Cantarella,  and Alessandro Weisz
9901-9910
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Targeting L1 cell adhesion molecule expression using liposome-encapsulated siRNA suppresses prostate cancer bone metastasis and growth

Targeting L1 cell adhesion molecule expression using liposome-encapsulated siRNA suppresses prostate cancer bone metastasis and growth

https://doi.org/10.18632/oncotarget.2478

Shian-Ying Sung, I-Hui Wu, Pei-Hsin Chuang, John A. Petros, Hsi-Chin Wu, Hong-Jie Zeng, Wei-Chien Huang, Leland W. K. Chung,  and Chia-Ling Hsieh
9911-9929
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Ibrutinib inhibits SDF1/CXCR4 mediated migration in AML

Ibrutinib inhibits SDF1/CXCR4 mediated migration in AML

https://doi.org/10.18632/oncotarget.2479

Lyubov Zaitseva, Megan Y. Murray, Manar S. Shafat, Matthew J. Lawes, David J. MacEwan, Kristian M. Bowles,  and Stuart A. Rushworth
9930-9938
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Characterization of single disseminated prostate cancer cells reveals tumor cell heterogeneity and identifies dormancy associated pathways

Characterization of single disseminated prostate cancer cells reveals tumor cell heterogeneity and identifies dormancy associated pathways

https://doi.org/10.18632/oncotarget.2480

Lisly Chéry, Hung-Ming Lam, Ilsa Coleman, Bryce Lakely, Roger Coleman, Sandy Larson, Julio A. Aguirre-Ghiso, Jing Xia, Roman Gulati, Peter S. Nelson, Bruce Montgomery, Paul Lange, Linda A. Snyder, Robert L. Vessella,  and Colm Morrissey
9939-9951
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Mutational profiles in triple-negative breast cancer defined by ultradeep multigene sequencing show high rates of PI3K pathway alterations and clinically relevant entity subgroup specific differences

Mutational profiles in triple-negative breast cancer defined by ultradeep multigene sequencing show high rates of PI3K pathway alterations and clinically relevant entity subgroup specific differences

https://doi.org/10.18632/oncotarget.2481

Mark Kriegsmann, Volker Endris, Thomas Wolf, Nicole Pfarr, Albrecht Stenzinger, Sibylle Loibl, Carsten Denkert, Andreas Schneeweiss, Jan Budczies, Peter Sinn,  and Wilko Weichert
9952-9965
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Glipizide, an antidiabetic drug, suppresses tumor growth and metastasis by inhibiting angiogenesis

Glipizide, an antidiabetic drug, suppresses tumor growth and metastasis by inhibiting angiogenesis

https://doi.org/10.18632/oncotarget.2483

Cuiling Qi, Qin Zhou, Bin Li, Yang Yang, Liu Cao, Yuxiang Ye, Jiangchao Li, Yi Ding, Huiping Wang, Jintao Wang, Xiaodong He, Qianqian Zhang, Tian Lan, Kenneth Ka Ho Lee, Weidong Li, Xiaoyu Song, Jia Zhou, Xuesong Yang,  and Lijing Wang
9966-9979
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

HSP90 inhibition downregulates thymidylate synthase and sensitizes colorectal cancer cell lines to the effect of 5FU-based chemotherapy

HSP90 inhibition downregulates thymidylate synthase and sensitizes colorectal cancer cell lines to the effect of 5FU-based chemotherapy

https://doi.org/10.18632/oncotarget.2484

Ganji Purnachandra Nagaraju, Olatunji B. Alese, Jerome Landry, Roberto Diaz,  and Bassel F. El-Rayes
9980-9991
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Galectin-3 leads to attenuation of apoptosis through Bax heterodimerization in human thyroid carcinoma cells

Galectin-3 leads to attenuation of apoptosis through Bax heterodimerization in human thyroid carcinoma cells

https://doi.org/10.18632/oncotarget.2486

Yosuke Harazono, Dhong Hyo Kho, Vitaly Balan, Kosei Nakajima, Tianpeng Zhang, Victor Hogan,  and Avraham Raz
9992-10001
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Src-dependent phosphorylation at Y406 on the thyroid hormone receptor β confers the tumor suppressor activity

Src-dependent phosphorylation at Y406 on the thyroid hormone receptor β confers the tumor suppressor activity

https://doi.org/10.18632/oncotarget.2487

Jeong Won Park, Li Zhao, Paul Webb,  and Sheue-yann Cheng
10002-10016
Abstract  |  PDF  |  HTML  |  Order a Reprint

Silibinin inhibits aberrant lipid metabolism, proliferation and emergence of androgen-independence in prostate cancer cells via primarily targeting the sterol response element binding protein 1

Silibinin inhibits aberrant lipid metabolism, proliferation and emergence of androgen-independence in prostate cancer cells via primarily targeting the sterol response element binding protein 1

https://doi.org/10.18632/oncotarget.2488

Dhanya K. Nambiar, Gagan Deep, Rana P. Singh, Chapla Agarwal,  and Rajesh Agarwal
10017-10033
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Activity of the novel mTOR inhibitor Torin-2 in B-precursor acute lymphoblastic leukemia and its therapeutic potential to prevent Akt reactivation

Activity of the novel mTOR inhibitor Torin-2 in B-precursor acute lymphoblastic leukemia and its therapeutic potential to prevent Akt reactivation

https://doi.org/10.18632/oncotarget.2490

Carolina Simioni, Alice Cani, Alberto M. Martelli, Giorgio Zauli, Giovanna Tabellini, James McCubrey, Silvano Capitani,  and Luca M. Neri
10034-10047
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

TERT promoter mutations and gene amplification: Promoting TERT expression in Merkel cell carcinoma

TERT promoter mutations and gene amplification: Promoting TERT expression in Merkel cell carcinoma

https://doi.org/10.18632/oncotarget.2491

Hong Xie, Tiantian Liu, Na Wang, Viveca Björnhagen, Anders Höög, Catharina Larsson, Weng-Onn Lui,  and Dawei Xu
10048-10057
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Differential β2-adrenergic receptor expression defines the phenotype of non-tumorigenic and malignant human breast cell lines

Differential β2-adrenergic receptor expression defines the phenotype of non-tumorigenic and malignant human breast cell lines

https://doi.org/10.18632/oncotarget.2460

Lucía Gargiulo, Sabrina Copsel, Ezequiel M. Rivero, Céline Galés, Jean-Michel Sénard, Isabel A. Lüthy, Carlos Davio,  and Ariana Bruzzone
10058-10069
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The tyrosine phosphatase PTPRO sensitizes colon cancer cells to anti-EGFR therapy through activation of SRC-mediated EGFR signaling

The tyrosine phosphatase PTPRO sensitizes colon cancer cells to anti-EGFR therapy through activation of SRC-mediated EGFR signaling

https://doi.org/10.18632/oncotarget.2458

Layka Abbasi Asbagh, Iria Vazquez, Loredana Vecchione, Eva Budinska, Veerle De Vriendt, Maria Francesca Baietti, Mikhail Steklov, Bart Jacobs, Nicholas Hoe, Sharat Singh, Naga-Sailaja Imjeti, Pascale Zimmermann, Anna Sablina,  and Sabine Tejpar
10070-10083
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

HAX1 regulates E3 ubiquitin ligase activity of cIAPs by promoting their dimerization

HAX1 regulates E3 ubiquitin ligase activity of cIAPs by promoting their dimerization

https://doi.org/10.18632/oncotarget.2459

Jin Sun Choi, Byoung Chul Park, Seung Wook Chi, Kwang-Hee Bae, Sunhong Kim, Sayeon Cho, Woo-Chan Son, Pyung Keun Myung, Jeong-Hoon Kim,  and Sung Goo Park
10084-10099
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Intratumoral administration of mRNA encoding a fusokine consisting of IFN-β and the ectodomain of the TGF-β receptor II potentiates antitumor immunity

Intratumoral administration of mRNA encoding a fusokine consisting of IFN-β and the ectodomain of the TGF-β receptor II potentiates antitumor immunity

https://doi.org/10.18632/oncotarget.2463

Kevin Van der Jeught, Patrick Tjok Joe, Lukasz Bialkowski, Carlo Heirman, Lidia Daszkiewicz, Therese Liechtenstein, David Escors, Kris Thielemans,  and Karine Breckpot
10100-10113
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Heptamethine carbocyanine dye-mediated near-infrared imaging of canine and human cancers through the HIF-1α/OATPs signaling axis

Heptamethine carbocyanine dye-mediated near-infrared imaging of canine and human cancers through the HIF-1α/OATPs signaling axis

https://doi.org/10.18632/oncotarget.2464

Changhong Shi, Jason Boyang Wu, Gina C-Y. Chu, Qinlong Li, Ruoxiang Wang, Caiqin Zhang, Yi Zhang, Hyung L. Kim, Haiyen E. Zhau, Dongfeng Pan,  and Leland W.K. Chung
10114-10126
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

TRIM16 inhibits proliferation and migration through regulation of interferon beta 1 in melanoma cells

TRIM16 inhibits proliferation and migration through regulation of interferon beta 1 in melanoma cells

https://doi.org/10.18632/oncotarget.2466

Selina K. Sutton, Jessica Koach, Owen Tan, Bing Liu, Daniel R. Carter, James S. Wilmott, Benafsha Yosufi, Lauren E. Haydu, Graham J. Mann, John F. Thompson, Georgina V. Long, Tao Liu, Grant McArthur, Xu Dong Zhang, Richard A. Scolyer, Belamy B. Cheung,  and Glenn M. Marshall
10127-10139
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Ciclopirox induces autophagy through reactive oxygen species-mediated activation of JNK signaling pathway

Ciclopirox induces autophagy through reactive oxygen species-mediated activation of JNK signaling pathway

https://doi.org/10.18632/oncotarget.2471

Hongyu Zhou, Tao Shen, Chaowei Shang, Yan Luo, Lei Liu, Juming Yan, Yan Li,  and Shile Huang
10140-10150
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Functional modification of adipocytes by grape seed extract impairs their pro-tumorigenic signaling on colon cancer stem cells and the daughter cancer cells

Functional modification of adipocytes by grape seed extract impairs their pro-tumorigenic signaling on colon cancer stem cells and the daughter cancer cells

https://doi.org/10.18632/oncotarget.2467

Sushil Kumar, Dileep Kumar, Komal Raina, Rajesh Agarwal,  and Chapla Agarwal
10151-10169
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

CCR9/CCL25 expression in non-small cell lung cancer correlates with aggressive disease and mediates key steps of metastasis

CCR9/CCL25 expression in non-small cell lung cancer correlates with aggressive disease and mediates key steps of metastasis

https://doi.org/10.18632/oncotarget.2526

Pranav Gupta, Praveen K. Sharma, Hina Mir, Rajesh Singh, Nalinaksha Singh, Goetz H. Kloecker, James W. Lillard, Jr.,  and Shailesh Singh
10170-10179
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HS-133, a novel fluorescent phosphatidylinositol 3-kinase inhibitor as a potential imaging and anticancer agent for targeted therapy

HS-133, a novel fluorescent phosphatidylinositol 3-kinase inhibitor as a potential imaging and anticancer agent for targeted therapy

https://doi.org/10.18632/oncotarget.2507

Ju-Hee Lee, Kyung Hee Jung, Hyunseung Lee, Mi Kwon Son, Sun-Mi Yun, Sung-Hoon Ahn, Kyeong-Ryoon Lee, Soyoung Lee, Donghee Kim, Sungwoo Hong,  and Soon-Sun Hong
10180-10197
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Signaling pathways activation profiles make better markers of cancer than expression of individual genes

Signaling pathways activation profiles make better markers of cancer than expression of individual genes

https://doi.org/10.18632/oncotarget.2548

Nikolay M. Borisov, Nadezhda V. Terekhanova, Alexander M. Aliper, Larisa S. Venkova, Philip Yu Smirnov, Sergey Roumiantsev, Mikhail B. Korzinkin, Alex A. Zhavoronkov,  and Anton A. Buzdin
10198-10205
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