Oncotarget

Vol 5, No 18

September 30, 2014

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About The Cover

Loss of obscurins downregulates RhoA signaling in attached MCF10A cells. See Perry et al.

Table of Contents

Editorial Materials

BRAF-mutant hematopoietic malignancies

BRAF-mutant hematopoietic malignancies

https://doi.org/10.18632/oncotarget.2448

Omar Abdel-Wahab,  and Christopher Y. Park
7980-7981
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Editorial

The reverse Warburg effect in osteosarcoma

The reverse Warburg effect in osteosarcoma

https://doi.org/10.18632/oncotarget.2352

Federica Sotgia, Ubaldo E. Martinez-Outschoorn,  and Michael P. Lisanti
7982-7983
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‘Sex’ in the cancer cell

‘Sex’ in the cancer cell

https://doi.org/10.18632/oncotarget.2355

Inam J. Lafta, Helen E. Bryant,  and Alastair S. H. Goldman
7984-7985
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Oncogene addiction: resetting the safety switch?

Oncogene addiction: resetting the safety switch?

https://doi.org/10.18632/oncotarget.2474

Yulin Li, Peter S. Choi,  and Dean W. Felsher
7986-7987
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Reviews

Screening for E3-Ubiquitin ligase inhibitors: challenges and opportunities

Screening for E3-Ubiquitin ligase inhibitors: challenges and opportunities

https://doi.org/10.18632/oncotarget.2431

Vivien Landré, Barak Rotblat, Sonia Melino, Francesca Bernassola,  and Gerry Melino
7988-8013
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The IGF signalling pathway in Wilms tumours - A report from the ENCCA Renal Tumours Biology-driven drug development workshop

The IGF signalling pathway in Wilms tumours - A report from the ENCCA Renal Tumours Biology-driven drug development workshop

https://doi.org/10.18632/oncotarget.2485

Mariana Maschietto, Jocelyn Charlton, Daniela Perotti, Paolo Radice, James I. Geller, Kathy Pritchard-Jones,  and Mark Weeks
8014-8026
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Correlation of long non-coding RNA expression with metastasis, drug resistance and clinical outcome in cancer

Correlation of long non-coding RNA expression with metastasis, drug resistance and clinical outcome in cancer

https://doi.org/10.18632/oncotarget.2469

Ehsan Malek, Sajjeev Jagannathan,  and James J. Driscoll
8027-8038
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Regulatory roles of LINE-1-encoded reverse transcriptase in cancer onset and progression

Regulatory roles of LINE-1-encoded reverse transcriptase in cancer onset and progression

https://doi.org/10.18632/oncotarget.2504

Ilaria Sciamanna, Alberto Gualtieri, Pier Vincenzo Piazza,  and Corrado Spadafora
8039-8051
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Research Perspectives

CUSP9* treatment protocol for recurrent glioblastoma: aprepitant, artesunate, auranofin, captopril, celecoxib, disulfiram, itraconazole, ritonavir, sertraline augmenting continuous low dose temozolomide

CUSP9* treatment protocol for recurrent glioblastoma: aprepitant, artesunate, auranofin, captopril, celecoxib, disulfiram, itraconazole, ritonavir, sertraline augmenting continuous low dose temozolomide

https://doi.org/10.18632/oncotarget.2408

Richard E. Kast, Georg Karpel-Massler,  and Marc-Eric Halatsch
8052-8082
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Priority Research Papers

Clinical multiplexed exome sequencing distinguishes adult oligodendroglial neoplasms from astrocytic and mixed lineage gliomas

Clinical multiplexed exome sequencing distinguishes adult oligodendroglial neoplasms from astrocytic and mixed lineage gliomas

https://doi.org/10.18632/oncotarget.2342

Jane B. Cryan, Sam Haidar, Lori A. Ramkissoon, Wenya Linda Bi, David S. Knoff, Nikolaus Schultz, Malak Abedalthagafi, Loreal Brown, Patrick Y. Wen, David A. Reardon, Ian F. Dunn, Rebecca D. Folkerth, Sandro Santagata, Neal I. Lindeman, Azra H. Ligon, Rameen Beroukhim, Jason L. Hornick, Brian M. Alexander, Keith L. Ligon,  and Shakti H. Ramkissoon
8083-8092
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Anti-cancer potency of tasquinimod is enhanced via albumin-binding facilitating increased uptake in the tumor microenvironment

Anti-cancer potency of tasquinimod is enhanced via albumin-binding facilitating increased uptake in the tumor microenvironment

https://doi.org/10.18632/oncotarget.2378

John T. Isaacs, Susan L. Dalrymple, Marc D. Rosen, Hans Hammers, Anders Olsson,  and Tomas Leanderson
8093-8106
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TAp73 promotes cell survival upon genotoxic stress by inhibiting p53 activity

TAp73 promotes cell survival upon genotoxic stress by inhibiting p53 activity

https://doi.org/10.18632/oncotarget.2440

Dongshi Chen, Lihua Ming, Fangdong Zou, Ye Peng, Bennett Van Houten, Jian Yu,  and Lin Zhang
8107-8122
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Clinical Research Papers

Identification of a DNA methylation signature to predict disease-free survival in locally advanced rectal cancer

Identification of a DNA methylation signature to predict disease-free survival in locally advanced rectal cancer

https://doi.org/10.18632/oncotarget.2347

Jochen Gaedcke, Andreas Leha, Rainer Claus, Dieter Weichenhan, Klaus Jung, Julia Kitz, Marian Grade, Hendrik A. Wolff, Peter Jo, Jérôme Doyen, Jean-Pierre Gérard, Steven A. Johnsen, Christoph Plass, Tim Beißbarth,  and Michael Ghadimi
8123-8135
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A first in man phase I trial of the oral immunomodulator, indoximod, combined with docetaxel in patients with metastatic solid tumors

A first in man phase I trial of the oral immunomodulator, indoximod, combined with docetaxel in patients with metastatic solid tumors

https://doi.org/10.18632/oncotarget.2357

Hatem H. Soliman, Erica Jackson, Tony Neuger, Claire E. Dees, Donald R. Harvey, Hyo Han, Roohi Ismail-Khan, Susan Minton, Nicholas N. Vahanian, Charles Link, Daniel M. Sullivan,  and Scott Antonia
8136-8146
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Co-expression of MET and CD47 is a novel prognosticator for survival of luminal-type breast cancer patients

Co-expression of MET and CD47 is a novel prognosticator for survival of luminal-type breast cancer patients

https://doi.org/10.18632/oncotarget.2385

Irène Baccelli, Albrecht Stenzinger, Vanessa Vogel, Berit Maria Pfitzner, Corinna Klein, Markus Wallwiener, Martina Scharpff, Massimo Saini, Tim Holland-Letz, Hans-Peter Sinn, Andreas Schneeweiss, Carsten Denkert, Wilko Weichert,  and Andreas Trumpp
8147-8160
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A phase I trial of the HIV protease inhibitor nelfinavir in adults with solid tumors

A phase I trial of the HIV protease inhibitor nelfinavir in adults with solid tumors

https://doi.org/10.18632/oncotarget.2415

Gideon M. Blumenthal, Joell J. Gills, Marc S. Ballas, Wendy B. Bernstein, Takefumi Komiya, Roopa Dechowdhury, Betsy Morrow, Hyejeong Root, Guinevere Chun, Cynthia Helsabeck, Seth M. Steinberg, Jaclyn LoPiccolo, Shigeru Kawabata, Erin R. Gardner, William D. Figg,  and Phillip A. Dennis
8161-8172
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Research Papers

A screen for transcription factor targets of glycogen synthase kinase-3 highlights an inverse correlation of NFκB and androgen receptor signaling in prostate cancer

A screen for transcription factor targets of glycogen synthase kinase-3 highlights an inverse correlation of NFκB and androgen receptor signaling in prostate cancer

https://doi.org/10.18632/oncotarget.2303

Victor M. Campa, Eder Baltziskueta, Nora Bengoa-Vergniory, Irantzu Gorroño-Etxebarria, Radosław Wesołowski, Jonathan Waxman,  and Robert M. Kypta
8173-8187
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Wogonin induces cell cycle arrest and erythroid differentiation in  imatinib-resistant K562 cells and primary CML cells

Wogonin induces cell cycle arrest and erythroid differentiation in  imatinib-resistant K562 cells and primary CML cells

https://doi.org/10.18632/oncotarget.2340

Hao Yang, Hui Hui, Qian Wang, Hui Li, Kai Zhao, Yuxin Zhou, Yu Zhu, Xiaotang Wang, Qidong You, Qinglong Guo,  and Na Lu
8188-8201
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Tissue-specific isoform switch and DNA hypomethylation of the pyruvate kinase PKM gene in human cancers

Tissue-specific isoform switch and DNA hypomethylation of the pyruvate kinase PKM gene in human cancers

https://doi.org/10.18632/oncotarget.1159

Shruti Desai, Minming Ding, Bin Wang, Zhimin Lu, Qi Zhao, Kenna Shaw, W K Alfred Yung, John N Weinstein, Ming Tan,  and Jun Yao
8202-8210
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Targeting CD13 (aminopeptidase-N) in turn downregulates ADAM17 by internalization in acute myeloid leukaemia cells

Targeting CD13 (aminopeptidase-N) in turn downregulates ADAM17 by internalization in acute myeloid leukaemia cells

https://doi.org/10.18632/oncotarget.1788

Sandrine Bouchet, Ruoping Tang, Fanny Fava, Ollivier Legrand,  and Brigitte Bauvois
8211-8222
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Population distribution and ancestry of the cancer protective MDM2 SNP285 (rs117039649)

Population distribution and ancestry of the cancer protective MDM2 SNP285 (rs117039649)

https://doi.org/10.18632/oncotarget.1910

Stian Knappskog, Liv B. Gansmo, Khadizha Dibirova, Andres Metspalu, Cezary Cybulski, Paolo Peterlongo, Lauri Aaltonen, Lars Vatten, Pål Romundstad, Kristian Hveem, Peter Devilee, Gareth D. Evans, Dongxin Lin, Guy Van Camp, Vangelis G. Manolopoulos, Ana Osorio, Lili Milani, Tayfun Ozcelik, Pierre Zalloua, Francis Mouzaya, Elena Bliznetz, Elena Balanovska, Elvira Pocheshkova, Vaidutis Kučinskas, Lubov Atramentova, Pagbajabyn Nymadawa, Konstantin Titov, Maria Lavryashina, Yuldash Yusupov, Natalia Bogdanova, Sergey Koshel, Jorge Zamora, David C. Wedge, Deborah Charlesworth, Thilo Dörk, Oleg Balanovsky,  and Per E. Lønning
8223-8234
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Activation of EGFR, HER2 and HER3 by neurotensin/neurotensin receptor 1 renders breast tumors aggressive yet highly responsive to lapatinib and metformin in mice

Activation of EGFR, HER2 and HER3 by neurotensin/neurotensin receptor 1 renders breast tumors aggressive yet highly responsive to lapatinib and metformin in mice

https://doi.org/10.18632/oncotarget.1632

Sandra Dupouy, Van Kien Doan, Zherui Wu, Najat Mourra, Olivier De Wever, Frédérique Penault Llorca, Anne Cayre, Amal Kouchkar, Anne Gompel,  and Patricia Forgez
8235-8251
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Neurotensin (NTS) and its receptor (NTSR1) causes EGFR, HER2 and HER3 over-expression and their autocrine/paracrine activation in lung tumors, confirming responsiveness to erlotinib

Neurotensin (NTS) and its receptor (NTSR1) causes EGFR, HER2 and HER3 over-expression and their autocrine/paracrine activation in lung tumors, confirming responsiveness to erlotinib

https://doi.org/10.18632/oncotarget.1633

Mohamad Younes, Zherui Wu, Sandra Dupouy, Audrey Mansuet Lupo, Najat Mourra, Takashi Takahashi, Jean-Francois Flejou, Jean Trédaniel, Jean François Régnard, Diane Damotte, Marco Alifano,  and Patricia Forgez
8252-8269
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Oncogenic RAS-induced senescence in human primary thyrocytes: molecular effectors and inflammatory secretome involved

Oncogenic RAS-induced senescence in human primary thyrocytes: molecular effectors and inflammatory secretome involved

https://doi.org/10.18632/oncotarget.2013

Maria Grazia Vizioli, Joana Santos, Silvana Pilotti, Mara Mazzoni, Maria Chiara Anania, Claudia Miranda, Sonia Pagliardini, Marco A. Pierotti, Jesus Gil,  and Angela Greco
8270-8283
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Transcriptomic profile induced in bone marrow mesenchymal stromal cells after interaction with multiple myeloma cells: implications in myeloma progression and myeloma bone disease

Transcriptomic profile induced in bone marrow mesenchymal stromal cells after interaction with multiple myeloma cells: implications in myeloma progression and myeloma bone disease

https://doi.org/10.18632/oncotarget.2058

Antonio Garcia-Gomez, Javier De Las Rivas, Enrique M. Ocio, Elena Díaz-Rodríguez, Juan C. Montero, Montserrat Martín, Juan F. Blanco, Fermín M. Sanchez-Guijo, Atanasio Pandiella, Jesús F. San Miguel,  and Mercedes Garayoa
8284-8305
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Chemical inhibition of acetyl-CoA carboxylase suppresses self-renewal growth of cancer stem cells

Chemical inhibition of acetyl-CoA carboxylase suppresses self-renewal growth of cancer stem cells

https://doi.org/10.18632/oncotarget.2059

Bruna Corominas-Faja, Elisabet Cuyàs, Juan Gumuzio, Joaquim Bosch-Barrera, Olatz Leis, Ángel G. Martin,  and Javier A. Menendez
8306-8316
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Feedback activation of STAT3 mediates trastuzumab resistance via upregulation of MUC1 and MUC4 expression

Feedback activation of STAT3 mediates trastuzumab resistance via upregulation of MUC1 and MUC4 expression

https://doi.org/10.18632/oncotarget.2135

Guangchao Li, Likun Zhao, Wei Li, Kexing Fan, Weizhu Qian, Sheng Hou, Hao Wang, Jianxin Dai, Huafeng Wei,  and Yajun Guo
8317-8329
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Peroxisome proliferator activated receptor alpha inhibits hepatocarcinogenesis through mediating NF-κB signaling pathway

Peroxisome proliferator activated receptor alpha inhibits hepatocarcinogenesis through mediating NF-κB signaling pathway

https://doi.org/10.18632/oncotarget.2212

Ning Zhang, Eagle S. H. Chu, Jingwan Zhang, Xiaoxing Li, Qiaoyi Liang, Jie Chen, Minhu Chen, Narci Teoh, Geoffrey Farrell, Joseph J. Y. Sung,  and Jun Yu
8330-8340
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

HMGA1 pseudogenes as candidate proto-oncogenic competitive endogenous RNAs

HMGA1 pseudogenes as candidate proto-oncogenic competitive endogenous RNAs

https://doi.org/10.18632/oncotarget.2202

Francesco Esposito, Marco De Martino, Maria Grazia Petti, Floriana Forzati, Mara Tornincasa, Antonella Federico, Claudio Arra, Giovanna Maria Pierantoni,  and Alfredo Fusco
8341-8354
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

ARID3B increases ovarian tumor burden and is associated with a cancer stem cell gene signature

ARID3B increases ovarian tumor burden and is associated with a cancer stem cell gene signature

https://doi.org/10.18632/oncotarget.2247

Lynn Roy, Serene J. Samyesudhas, Martin Carrasco, Jun Li, Stancy Joseph, Richard Dahl,  and Karen D. Cowden Dahl
8355-8366
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Oncogene-triggered suppression of DNA repair leads to DNA instability in cancer

Oncogene-triggered suppression of DNA repair leads to DNA instability in cancer

https://doi.org/10.18632/oncotarget.2259

Julia A. Yaglom, Christopher McFarland, Leonid Mirny,  and Michael Y. Sherman
8367-8378
Abstract  |  PDF  |  HTML  |  Order a Reprint

Picropodophyllin causes mitotic arrest and catastrophe by depolymerizing microtubules via Insulin-like growth factor-1 receptor-independent mechanism

Picropodophyllin causes mitotic arrest and catastrophe by depolymerizing microtubules via Insulin-like growth factor-1 receptor-independent mechanism

https://doi.org/10.18632/oncotarget.2292

Ahmed Waraky, Karen Akopyan, Vendela Parrow, Thomas Strömberg, Magnus Axelson, Lars Abrahmsén, Arne Lindqvist, Olle Larsson,  and Eiman Aleem
8379-8392
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

TALEN-mediated Nanog disruption results in less invasiveness, more chemosensitivity and reversal of EMT in Hela cells

TALEN-mediated Nanog disruption results in less invasiveness, more chemosensitivity and reversal of EMT in Hela cells

https://doi.org/10.18632/oncotarget.2298

Yan Ding, Ai Qing Yu, Cheng Lin Li, Juan Fang, Yi Zeng,  and Dong Sheng Li
8393-8401
Abstract  |  PDF  |  HTML  |  Order a Reprint

Therapeutic effect of a TM4SF5-specific monoclonal antibody against colon cancer in a mouse model

Therapeutic effect of a TM4SF5-specific monoclonal antibody against colon cancer in a mouse model

https://doi.org/10.18632/oncotarget.2311

Young-Eun Kim, Sanghoon Kwon, Guang Wu, Dongbum Kim, Byoung Kwon Park, Jeong-A Park, Kyung-Chan Choi, Doo-Sik Kim, Hyung-Joo Kwon,  and Younghee Lee
8402-8415
Abstract  |  PDF  |  HTML  |  Order a Reprint

Inhibition of STAT3 signaling targets both tumor-initiating and differentiated cell populations in prostate cancer

Inhibition of STAT3 signaling targets both tumor-initiating and differentiated cell populations in prostate cancer

https://doi.org/10.18632/oncotarget.2314

Zhiqiang Han, Xiaoli Wang, Liang Ma, Lijuan Chen, Min Xiao, Liang Huang, Yang Cao, Jian Bai, Ding Ma, Jianfeng Zhou,  and Zhenya Hong
8416-8428
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Interferon-stimulated gene 15 (ISG15) is a trigger for tumorigenesis and metastasis of hepatocellular carcinoma

Interferon-stimulated gene 15 (ISG15) is a trigger for tumorigenesis and metastasis of hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.2316

Chong Li, Ji Wang, Hong Zhang, Mingao Zhu, Feifei Chen, Yufeng Hu, Hudan Liu,  and Hong Zhu
8429-8441
Abstract  |  PDF  |  HTML  |  Order a Reprint

Regulatory effects of a Mnk2-eIF4E feedback loop during mTORC1 targeting of human medulloblastoma cells

Regulatory effects of a Mnk2-eIF4E feedback loop during mTORC1 targeting of human medulloblastoma cells

https://doi.org/10.18632/oncotarget.2319

Frank Eckerdt, Elspeth Beauchamp, Jonathan Bell, Asneha Iqbal, Bing Su, Rikiro Fukunaga, Rishi R. Lulla, Stewart Goldman,  and Leonidas C. Platanias
8442-8451
Abstract  |  PDF  |  HTML  |  Order a Reprint

Nuclear and cytoplasmic p53 suppress cell invasion by inhibiting respiratory Complex-I activity via Bcl-2 family proteins

Nuclear and cytoplasmic p53 suppress cell invasion by inhibiting respiratory Complex-I activity via Bcl-2 family proteins

https://doi.org/10.18632/oncotarget.2320

Eun Mi Kim, Jong Kuk Park, Sang-Gu Hwang, Wun-Jae Kim, Zheng-Gang Liu, Sang Won Kang,  and Hong-Duck Um
8452-8465
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

PIWIL2 induces c-Myc expression by interacting with NME2 and regulates c-Myc-mediated tumor cell proliferation

PIWIL2 induces c-Myc expression by interacting with NME2 and regulates c-Myc-mediated tumor cell proliferation

https://doi.org/10.18632/oncotarget.2327

Youlin Yao, Chao Li, Xiaoyan Zhou, Yu Zhang, Yilu Lu, Jianhui Chen, Xulei Zheng, Dachang Tao, Yunqiang Liu,  and Yongxin Ma
8466-8477
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The iron chelator Dp44mT inhibits hepatocellular carcinoma metastasis via N-Myc downstream-regulated gene 2 (NDRG2)/gp130/STAT3 pathway

The iron chelator Dp44mT inhibits hepatocellular carcinoma metastasis via N-Myc downstream-regulated gene 2 (NDRG2)/gp130/STAT3 pathway

https://doi.org/10.18632/oncotarget.2328

Jiabei Wang, Dalong Yin, Changming Xie, Tongsen Zheng, Yingjian Liang, Xuehui Hong, Zhaoyang Lu, Xuan Song, Ruipeng Song, Haiyan Yang, Boshi Sun, Nishant Bhatta, Xianzhi Meng, Shangha Pan, Hongchi Jiang,  and Lianxin Liu
8478-8491
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Spinophilin expression determines cellular growth, cancer stemness and 5-flourouracil resistance in colorectal cancer

Spinophilin expression determines cellular growth, cancer stemness and 5-flourouracil resistance in colorectal cancer

https://doi.org/10.18632/oncotarget.2329

Anna Lena Ress, Verena Stiegelbauer, Daniela Schwarzenbacher, Alexander Deutsch, Samantha Perakis, Hui Ling, Cristina Ivan, George Adrian Calin, Beate Rinner, Armin Gerger,  and Martin Pichler
8492-8502
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The PIM family of oncoproteins: small kinases with huge implications in myeloid leukemogenesis and as therapeutic targets

The PIM family of oncoproteins: small kinases with huge implications in myeloid leukemogenesis and as therapeutic targets

https://doi.org/10.18632/oncotarget.2330

Kumar Saurabh, Michael T. Scherzer, Parag P. Shah, Alice S. Mims, William W. Lockwood, Andrew S. Kraft,  and Levi J. Beverly
8503-8514
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Efficient lytic induction of kaposi’s sarcoma-associated herpesvirus (KSHV) by the anthracyclines

Efficient lytic induction of kaposi’s sarcoma-associated herpesvirus (KSHV) by the anthracyclines

https://doi.org/10.18632/oncotarget.2335

Hyunju Kang, Jaehyung Song, Kwangman Choi, Hyeongki Kim, Miri Choi, So-Young Lee, Chonsaeng Kim, Sang Jun Lee, Moon Jung Song, Hyojeung Kang, Sung Hoon Back, Sang-Bae Han,  and Sungchan Cho
8515-8527
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Inhibition of lung tumor growth by targeting EGFR/VEGFR-Akt/NF-κB pathways with novel theanine derivatives

Inhibition of lung tumor growth by targeting EGFR/VEGFR-Akt/NF-κB pathways with novel theanine derivatives

https://doi.org/10.18632/oncotarget.2336

Guoying Zhang, Xinshan Ye, Dexin Ji, Huarong Zhang, Fujia Sun, Chunqing Shang, Ying Zhang, Erxi Wu, Fengfei Wang, Fei Wu, Huihui Tian, Xin Liu, Linlin Chen, Kun Liu, Hanchen Liu, Yishan Wang, Wenhua Zhang, Yukun Guan, Qinwen Wang, Xiaohang Zhao,  and Xiaochun Wan
8528-8543
Abstract  |  PDF  |  HTML  |  Order a Reprint

Catalytic mTOR inhibitors can overcome intrinsic and acquired resistance to allosteric mTOR inhibitors

Catalytic mTOR inhibitors can overcome intrinsic and acquired resistance to allosteric mTOR inhibitors

https://doi.org/10.18632/oncotarget.2337

Burhan Hassan, Argun Akcakanat, Takafumi Sangai, Kurt W. Evans, Farrell Adkins, Agda Karina Eterovic, Hao Zhao, Ken Chen, Huiqin Chen, Kim-Anh Do, Shelly M. Xie, Ashley M. Holder, Aung Naing, Gordon B. Mills,  and Funda Meric-Bernstam
8544-8557
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Loss of the obscurin-RhoGEF downregulates RhoA signaling and increases microtentacle formation and attachment of breast epithelial cells

Loss of the obscurin-RhoGEF downregulates RhoA signaling and increases microtentacle formation and attachment of breast epithelial cells

https://doi.org/10.18632/oncotarget.2338

Nicole A. Perry, Michele I. Vitolo, Stuart S. Martin,  and Aikaterini Kontrogianni-Konstantopoulos
8558-8568
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

ATF3 functions as a novel tumor suppressor with prognostic significance in esophageal squamous cell carcinoma

ATF3 functions as a novel tumor suppressor with prognostic significance in esophageal squamous cell carcinoma

https://doi.org/10.18632/oncotarget.2322

Jian-Jun Xie, Yang-Min Xie, Bo Chen, Feng Pan, Jin-Cheng Guo, Qing Zhao, Jin-Hui Shen, Zhi-Yong Wu, Jian-Yi Wu, Li-Yan Xu,  and En-Min Li
8569-8582
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Epstein-Barr virus BALF3 mediates genomic instability and progressive malignancy in nasopharyngeal carcinoma

Epstein-Barr virus BALF3 mediates genomic instability and progressive malignancy in nasopharyngeal carcinoma

https://doi.org/10.18632/oncotarget.2323

Shih-Hsin Chiu, Chung-Chun Wu, Chih-Yeu Fang, Shu-Ling Yu, Hui-Yu Hsu, Yen-Hung Chow,  and Jen-Yang Chen
8583-8601
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Interfering with the interaction between ErbB1, nucleolin and Ras as a potential treatment for glioblastoma

Interfering with the interaction between ErbB1, nucleolin and Ras as a potential treatment for glioblastoma

https://doi.org/10.18632/oncotarget.2343

Yona Goldshmit, Sari Schokoroy Trangle, Yoel Kloog,  and Ronit Pinkas-Kramarski
8602-8613
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Selective targeting of liver cancer with the endothelial marker CD146

Selective targeting of liver cancer with the endothelial marker CD146

https://doi.org/10.18632/oncotarget.2345

Stefan Thomann, Thomas Longerich, Alexandr V. Bazhin, Walter Mier, Peter Schemmer,  and Eduard Ryschich
8614-8624
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Integrated analysis of long noncoding RNAs and mRNAs reveals their potential roles in the pathogenesis of uterine leiomyomas

Integrated analysis of long noncoding RNAs and mRNAs reveals their potential roles in the pathogenesis of uterine leiomyomas

https://doi.org/10.18632/oncotarget.2349

Haiyang Guo, Xiyu Zhang, Ruifen Dong, Xiaolin Liu, Yinuo Li, Shan Lu, Limei Xu, Yuqiong Wang, Xiyao Wang, Dong Hou, Jian-Jun Wei, Changshun Shao,  and Zhaojian Liu
8625-8636
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Selective JAK2/ABL dual inhibition therapy effectively eliminates TKI-insensitive CML stem/progenitor cells

Selective JAK2/ABL dual inhibition therapy effectively eliminates TKI-insensitive CML stem/progenitor cells

https://doi.org/10.18632/oncotarget.2353

Hanyang Lin, Min Chen, Katharina Rothe, Matthew V. Lorenzi, Adrian Woolfson,  and Xiaoyan Jiang
8637-8650
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Acquired convergence of hormone signaling in breast cancer: ER and PR transition from functionally distinct in normal breast to predictors of metastatic disease

Acquired convergence of hormone signaling in breast cancer: ER and PR transition from functionally distinct in normal breast to predictors of metastatic disease

https://doi.org/10.18632/oncotarget.2354

Heidi N. Hilton, Tram B. Doan, J. Dinny Graham, Samantha R. Oakes, Audrey Silvestri, Nicole Santucci, Silke Kantimm, Lily I. Huschtscha, Christopher J. Ormandy, John W. Funder, Evan R. Simpson, Elizabeth S. Kuczek, Peter J. Leedman, Wayne D. Tilley, Peter J. Fuller, George E. O. Muscat,  and Christine L. Clarke
8651-8664
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Induced cancer stem-like cells as a model for biological screening and discovery of agents targeting phenotypic traits of cancer stem cell

Induced cancer stem-like cells as a model for biological screening and discovery of agents targeting phenotypic traits of cancer stem cell

https://doi.org/10.18632/oncotarget.2356

Mayuko Nishi, Hidenori Akutsu, Ayumi Kudoh, Hirokazu Kimura, Naoki Yamamoto, Akihiro Umezawa, Sam W. Lee,  and Akihide Ryo
8665-8680
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Splice variant transcripts of the anterior gradient 2 gene as a marker of prostate cancer

Splice variant transcripts of the anterior gradient 2 gene as a marker of prostate cancer

https://doi.org/10.18632/oncotarget.2365

Antje Neeb, Simon Hefele, Stefanie Bormann, Walther Parson, Fabian Adams, Philipp Wolf, Arkadiusz Miernik, Martin Schoenthaler, Malte Kroenig, Konrad Wilhelm, Wolfgang Schultze-Seemann, Sigrun Nestel, Georg Schaefer, Huajie Bu, Helmut Klocker, Irina Nazarenko,  and Andrew C. B. Cato
8681-8689
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Intracellular and extracellular domains of protein tyrosine phosphatase PTPRZ-B differentially regulate glioma cell growth and motility

Intracellular and extracellular domains of protein tyrosine phosphatase PTPRZ-B differentially regulate glioma cell growth and motility

https://doi.org/10.18632/oncotarget.2366

Annika M. Bourgonje, Anna C. Navis, Jan T.G. Schepens, Kiek Verrijp, Liesbeth Hovestad, Riet Hilhorst, Sheila Harroch, Pieter Wesseling, William P.J. Leenders,  and Wiljan J.A.J. Hendriks
8690-8702
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Multiple blocks in the engagement of oxidative phosphorylation in putative ovarian cancer stem cells: implication for maintenance therapy with glycolysis inhibitors

Multiple blocks in the engagement of oxidative phosphorylation in putative ovarian cancer stem cells: implication for maintenance therapy with glycolysis inhibitors

https://doi.org/10.18632/oncotarget.2367

Ayesha B. Alvero, Michele K. Montagna, Natalia J. Sumi, Won Duk Joo, Emma Graham,  and Gil Mor
8703-8715
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IL-6-stimulated CD11b+ CD14+ HLA-DR myeloid-derived suppressor cells, are associated with progression and poor prognosis in squamous cell carcinoma of the esophagus

IL-6-stimulated CD11b+ CD14+ HLA-DR myeloid-derived suppressor cells, are associated with progression and poor prognosis in squamous cell carcinoma of the esophagus

https://doi.org/10.18632/oncotarget.2368

Miao-Fen Chen, Feng-Che Kuan, Tzu-Chen Yen, Ming-Shian Lu, Paul-Yang Lin, Yi-Hsiu Chung, Wen-Cheng Chen,  and Kuan-Der Lee
8716-8728
Abstract  |  PDF  |  HTML  |  Order a Reprint

Selective methioninase-induced trap of cancer cells in S/G2 phase visualized by FUCCI imaging confers chemosensitivity

Selective methioninase-induced trap of cancer cells in S/G2 phase visualized by FUCCI imaging confers chemosensitivity

https://doi.org/10.18632/oncotarget.2369

Shuya Yano, Shukuan Li, Qinghong Han, Yuying Tan, Michael Bouvet, Toshiyoshi Fujiwara,  and Robert M. Hoffman
8729-8736
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Molecular rationale for the use of PI3K/AKT/mTOR pathway inhibitors in combination with crizotinib in ALK-mutated neuroblastoma

Molecular rationale for the use of PI3K/AKT/mTOR pathway inhibitors in combination with crizotinib in ALK-mutated neuroblastoma

https://doi.org/10.18632/oncotarget.2372

Nathan F. Moore, Anna M. Azarova, Namrata Bhatnagar, Kenneth N. Ross, Lauren E. Drake, Stacey Frumm, Qinsong S. Liu, Amanda L. Christie, Takaomi Sanda, Louis Chesler, Andrew L. Kung, Nathanael S. Gray, Kimberly Stegmaier,  and Rani E. George
8737-8749
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Using heterogeneity of the patient-derived xenograft model to identify the chemoresistant population in ovarian cancer

Using heterogeneity of the patient-derived xenograft model to identify the chemoresistant population in ovarian cancer

https://doi.org/10.18632/oncotarget.2373

Zachary C. Dobbin, Ashwini A. Katre, Adam D. Steg, Britt K. Erickson, Monjri M. Shah, Ronald D. Alvarez, Michael G. Conner, David Schneider, Dongquan Chen,  and Charles N. Landen
8750-8764
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Interleukin-32α downregulates the activity of the B-cell CLL/lymphoma 6 protein by inhibiting protein kinase Cε-dependent SUMO-2 modification

Interleukin-32α downregulates the activity of the B-cell CLL/lymphoma 6 protein by inhibiting protein kinase Cε-dependent SUMO-2 modification

https://doi.org/10.18632/oncotarget.2364

Yun Sun Park, Jeong-Woo Kang, Dong Hun Lee, Man Sub Kim, Yesol Bak, Young Yang, Hee Gu Lee, JinTae Hong,  and Do-Young Yoon
8765-8777
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p-21 activated kinase 4 promotes proliferation and survival of pancreatic cancer cells through AKT- and ERK-dependent activation of NF-κB pathway

p-21 activated kinase 4 promotes proliferation and survival of pancreatic cancer cells through AKT- and ERK-dependent activation of NF-κB pathway

https://doi.org/10.18632/oncotarget.2398

Nikhil Tyagi, Arun Bhardwaj, Ajay P. Singh, Steven McClellan, James E. Carter,  and Seema Singh
8778-8789
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IsomiR expression profiles in human lymphoblastoid cell lines exhibit population and gender dependencies

IsomiR expression profiles in human lymphoblastoid cell lines exhibit population and gender dependencies

https://doi.org/10.18632/oncotarget.2405

Phillipe Loher, Eric R. Londin,  and Isidore Rigoutsos
8790-8802
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POU2F1 activity regulates HOXD10 and HOXD11 promoting a proliferative and invasive phenotype in Head and Neck cancer

POU2F1 activity regulates HOXD10 and HOXD11 promoting a proliferative and invasive phenotype in Head and Neck cancer

https://doi.org/10.18632/oncotarget.2492

Daniel J. Sharpe, Katy S. Orr, Michael Moran, Sharon J. White, Stephen McQuaid, Terence R. Lappin, Alexander Thompson,  and Jacqueline A. James
8803-8815
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