Oncotarget

Vol 5, No 17

September 15, 2014

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Mutations in CIC and IDH1 cooperatively regulate 2-hydroxyglutarate levels and cell clonogenicity. See Chittaranjan et al.

Table of Contents

Editorial

Contact inhibition against senescence

Contact inhibition against senescence

https://doi.org/10.18632/oncotarget.2446

Peiqing Sun
7212-7213
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mTORC2 takes the longevity stAGE

mTORC2 takes the longevity stAGE

https://doi.org/10.18632/oncotarget.2457

Dudley W. Lamming
7214-7215
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News

Targeting STAT6 in PMBL

Targeting STAT6 in PMBL

https://doi.org/10.18632/oncotarget.2447

Karen Leroy, Anais Pujals,  and Laura Pelletier
7216
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Reviews

Molecular pathways and targets in prostate cancer

Molecular pathways and targets in prostate cancer

https://doi.org/10.18632/oncotarget.2406

Emma Shtivelman, Tomasz M. Beer,  and Christopher P. Evans
7217-7259
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TWIST and ovarian cancer stem cells: implications for chemoresistance and metastasis

TWIST and ovarian cancer stem cells: implications for chemoresistance and metastasis

https://doi.org/10.18632/oncotarget.2428

Sudhakar V. Nuti, Gil Mor, Peiyao Li,  and Gang Yin
7260-7271
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Altered Mucins (MUC) Trafficking in Benign and Malignant Conditions

Altered Mucins (MUC) Trafficking in Benign and Malignant Conditions

https://doi.org/10.18632/oncotarget.2370

Suhasini Joshi, Sushil Kumar, Amit Choudhury, Moorthy P. Ponnusamy,  and Surinder K. Batra
7272-7284
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The structural basis for cancer treatment decisions

The structural basis for cancer treatment decisions

https://doi.org/10.18632/oncotarget.2439

Ruth Nussinov, Hyunbum Jang,  and Chung-Jung Tsai
7285-7302
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Priority Research Papers

Acetylation-defective mutants of Pparγ are associated with decreased lipid synthesis in breast cancer cells

Acetylation-defective mutants of Pparγ are associated with decreased lipid synthesis in breast cancer cells

https://doi.org/10.18632/oncotarget.2371

Lifeng Tian, Chenguang Wang, Fred K. Hagen, Michael Gormley, Sankar Addya, Raymond Soccio, Mathew C. Casimiro, Jie Zhou, Michael J. Powell, Ping Xu, Haiteng Deng, Anthon A. Sauve,  and Richard G. Pestell
7303-7315
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

AP4 is required for mitogen- and c-MYC-induced cell cycle progression

AP4 is required for mitogen- and c-MYC-induced cell cycle progression

https://doi.org/10.18632/oncotarget.2348

Rene Jackstadt,  and Heiko Hermeking
7316-7327
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Overcoming EMT-associated resistance to anti-cancer drugs via Src/FAK pathway inhibition

Overcoming EMT-associated resistance to anti-cancer drugs via Src/FAK pathway inhibition

https://doi.org/10.18632/oncotarget.2397

Catherine Wilson, Katrina Nicholes, Daisy Bustos, Eva Lin, Qinghua Song, Jean-Philippe Stephan, Donald S. Kirkpatrick,  and Jeff Settleman
7328-7341
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Epigenetic suppression of EGFR signaling in G-CIMP+ glioblastomas

Epigenetic suppression of EGFR signaling in G-CIMP+ glioblastomas

https://doi.org/10.18632/oncotarget.2350

Jie Li, Zachary J. Taich, Amit Goyal, David Gonda, Johnny Akers, Bandita Adhikari, Kunal Patel, Scott Vandenberg, Wei Yan, Zhaoshi Bao, Bob S. Carter, Renzhi Wang, Ying Mao, Tao Jiang,  and Clark C. Chen
7342-7356
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Clinical Research Papers

Nuclear Eg5 (kinesin spindle protein) expression predicts docetaxel response and prostate cancer aggressiveness

Nuclear Eg5 (kinesin spindle protein) expression predicts docetaxel response and prostate cancer aggressiveness

https://doi.org/10.18632/oncotarget.1985

Michel D. Wissing, Ellen S. De Morrée, Vincent O. Dezentjé, Jeroen T. Buijs, Ronald R. De Krijger, Vincent T.H.B.M. Smit, Wytske M. Van Weerden, Hans Gelderblom,  and Gabri van der Pluijm
7357-7367
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Clinical outcomes of a novel combination of lenalidomide and rituximab followed by stem cell transplantation for relapsed/refractory aggressive B-cell non-hodgkin lymphoma

Clinical outcomes of a novel combination of lenalidomide and rituximab followed by stem cell transplantation for relapsed/refractory aggressive B-cell non-hodgkin lymphoma

https://doi.org/10.18632/oncotarget.2255

Qingqing Cai, Yiming Chen, Dehui Zou, Liang Zhang, Maria Badillo, Shouhao Zhou, Elyse Lopez, Wenqi Jiang, Huiqiang Huang, Tongyu Lin, Jorge Romaguera,  and Michael Wang
7368-7380
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18 FDG-PET/CT for prognostic stratification of patients with multiple myeloma relapse after stem cell transplantation

18 FDG-PET/CT for prognostic stratification of patients with multiple myeloma relapse after stem cell transplantation

https://doi.org/10.18632/oncotarget.2290

Constantin Lapa, Katharina Lückerath, Uwe Malzahn, Samuel Samnick, Herrmann Einsele, Andreas K. Buck, Ken Herrmann,  and Stefan Knop
7381-7391
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Research Papers

NM23-H1 expression of head and neck squamous cell carcinoma in association with the response to cisplatin treatment

NM23-H1 expression of head and neck squamous cell carcinoma in association with the response to cisplatin treatment

https://doi.org/10.18632/oncotarget.1912

Yi-Fen Wang, Chun-Ju Chang, Jen-Hwey Chiu, Chin-Ping Lin, Wing-Yin Li, Shyue-Yih Chang, Pen-Yuan Chu, Shyh-Kuan Tai,  and Yu-Jen Chen
7392-7405
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Common reduction of the Raf kinase inhibitory protein in clear cell renal cell carcinoma

Common reduction of the Raf kinase inhibitory protein in clear cell renal cell carcinoma

https://doi.org/10.18632/oncotarget.1558

Brianne Hill, Jason De Melo, Judy Yan, Anil Kapoor, Lizhi He, Jean-Claude Cutz, Xiangchang Feng, Nazihah Bakhtyar,  and Damu Tang
7406-7419
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Applicability of the methylated CpG sites of paired box 5 (PAX5) promoter for prediction the prognosis of gastric cancer

Applicability of the methylated CpG sites of paired box 5 (PAX5) promoter for prediction the prognosis of gastric cancer

https://doi.org/10.18632/oncotarget.1973

Jingyu Deng, Han Liang, Rupeng Zhang, Qiuping Dong, Yachao Hou, Jun Yu, Daiming Fan,  and Xishan Hao
7420-7430
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Selenocysteine derivative overcomes TRAIL resistance in melanoma cells: evidence for ROS-dependent synergism and signaling crosstalk

Selenocysteine derivative overcomes TRAIL resistance in melanoma cells: evidence for ROS-dependent synergism and signaling crosstalk

https://doi.org/10.18632/oncotarget.2008

Wenqiang Cao, Xiaoling Li, Shanyuan Zheng, Wenjie Zheng, Yum-shing Wong,  and Tianfeng Chen
7431-7445
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

TRIM8 anti-proliferative action against chemo-resistant renal cell carcinoma

TRIM8 anti-proliferative action against chemo-resistant renal cell carcinoma

https://doi.org/10.18632/oncotarget.2081

Mariano Francesco Caratozzolo, Alessio Valletti, Margherita Gigante, Italia Aiello, Francesca Mastropasqua, Flaviana Marzano, Pasquale Ditonno, Giuseppe Carrieri, Hélène Simonnet, Anna Maria D’Erchia, Elena Ranieri, Graziano Pesole, Elisabetta Sbisà,  and Apollonia Tullo
7446-7457
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High mobility group Box-1 inhibits cancer cell motility and metastasis by suppressing activation of transcription factor CREB and nWASP expression

High mobility group Box-1 inhibits cancer cell motility and metastasis by suppressing activation of transcription factor CREB and nWASP expression

https://doi.org/10.18632/oncotarget.2150

Zhenghong Zuo, Xun Che, Yulei Wang, Bowen Li, Jingxia Li, Wei Dai, Charles P. Lin,  and Chuanshu Huang
7458-7470
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Liposome encapsulated Disulfiram inhibits NFκB pathway and targets breast cancer stem cells in vitro and in vivo

Liposome encapsulated Disulfiram inhibits NFκB pathway and targets breast cancer stem cells in vitro and in vivo

https://doi.org/10.18632/oncotarget.2166

Peng Liu, Zhipeng Wang, Sarah Brown, Vinodh Kannappan, Patricia Erebi Tawari, Wenguo Jiang, Juan M. Irache, James Z. Tang, Stephen Britland, Angel L. Armesilla, John L. Darling, Weiguang Wang,  and Weiguang Wang Wang
7471-7485
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EMT and EGFR in CTCs cytokeratin negative non-metastatic breast cancer

EMT and EGFR in CTCs cytokeratin negative non-metastatic breast cancer

https://doi.org/10.18632/oncotarget.2217

Maria J. Serrano, Francisco G. Ortega, Maria J. Alvarez-Cubero, Rosa Nadal, Pedro Sanchez-Rovira, Marta Salido, María Rodríguez, Jose L. García-Puche, Miguel Delgado-Rodriguez, Francisco Solé, Maria A. García, Macarena Perán, Rafael Rosell, Juan A. Marchal,  and Jose A. Lorente
7486-7497
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Aurora kinase a suppresses metabolic stress-induced autophagic cell death by activating mTOR signaling in breast cancer cells

Aurora kinase a suppresses metabolic stress-induced autophagic cell death by activating mTOR signaling in breast cancer cells

https://doi.org/10.18632/oncotarget.2241

Ling-Zhi Xu, Zi-Jie Long, Fei Peng, Yang Liu, Jie Xu, Chang Wang, Lei Jiang, Tao Guo, Muhammad Kamran, Si-Si Li, Chun-Li Wang, Hong-Jiang Wang, Yong-Fu Zhao, Xian-Yao Wan,  and Quentin Liu
7498-7511
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Inhibition of protein phosphatase 2A with a small molecule LB100 radiosensitizes nasopharyngeal carcinoma xenografts by inducing mitotic catastrophe and blocking DNA damage repair

Inhibition of protein phosphatase 2A with a small molecule LB100 radiosensitizes nasopharyngeal carcinoma xenografts by inducing mitotic catastrophe and blocking DNA damage repair

https://doi.org/10.18632/oncotarget.2258

Peng Lv, Yue Wang, Jie Ma, Zheng Wang, Jing-Li Li, Christopher S. Hong, Zhengping Zhuang,  and Yi-Xin Zeng
7512-7524
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Beclin-1-independent autophagy positively regulates internal ribosomal entry site-dependent translation of hypoxia-inducible factor 1α under nutrient deprivation

Beclin-1-independent autophagy positively regulates internal ribosomal entry site-dependent translation of hypoxia-inducible factor 1α under nutrient deprivation

https://doi.org/10.18632/oncotarget.2265

Ching-An Wu, Duen-Yi Huang,  and Wan-Wan Lin
7525-7539
Abstract  |  PDF  |  HTML  |  Order a Reprint

Array-based genome-wide RNAi screening to identify shRNAs that enhance p53-related apoptosis in human cancer cells

Array-based genome-wide RNAi screening to identify shRNAs that enhance p53-related apoptosis in human cancer cells

https://doi.org/10.18632/oncotarget.2272

Masashi Idogawa, Tomoko Ohashi, Jun Sugisaka, Yasushi Sasaki, Hiromu Suzuki,  and Takashi Tokino
7540-7548
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Elevated TAK1 augments tumor growth and metastatic capacities of ovarian cancer cells through activation of NF-κB signaling

Elevated TAK1 augments tumor growth and metastatic capacities of ovarian cancer cells through activation of NF-κB signaling

https://doi.org/10.18632/oncotarget.2273

Patty C.H. Cai, Lei Shi, Vincent W.S. Liu, Hermit W.M. Tang, Iris J. Liu, Thomas H.Y. Leung, Karen K.L. Chan, Judy W.P. Yam, Kwok-Ming Yao, Hextan Y.S. Ngan,  and David W. Chan
7549-7562
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

βTrCP controls the lysosome-mediated degradation of CDK1, whose accumulation correlates with tumor malignancy

βTrCP controls the lysosome-mediated degradation of CDK1, whose accumulation correlates with tumor malignancy

https://doi.org/10.18632/oncotarget.2274

Joaquín Herrero-Ruiz, Mar Mora-Santos, Servando Giráldez, Carmen Sáez, Miguel Á. Japón, Maria Tortolero,  and Francisco Romero
7563-7574
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Role of mesenchymal stem cells in osteosarcoma and metabolic reprogramming of tumor cells

Role of mesenchymal stem cells in osteosarcoma and metabolic reprogramming of tumor cells

https://doi.org/10.18632/oncotarget.2243

Gloria Bonuccelli, Sofia Avnet, Giulia Grisendi, Manuela Salerno, Donatella Granchi, Massimo Dominici, Katsuyuki Kusuzaki,  and Nicola Baldini
7575-7588
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Osteoblast-derived WISP-1 increases VCAM-1 expression and enhances prostate cancer metastasis by down-regulating miR-126

Osteoblast-derived WISP-1 increases VCAM-1 expression and enhances prostate cancer metastasis by down-regulating miR-126

https://doi.org/10.18632/oncotarget.2280

Huai-Ching Tai, An-Chen Chang, Hong-Jeng Yu, Chao-Yuan Huang, Yu-Chieh Tsai, Yu-Wei Lai, Hui-Lung Sun, Chih-Hsin Tang,  and Shih-Wei Wang
7589-7598
Abstract  |  PDF  |  HTML  |  Order a Reprint

MicroRNA-145 targets MUC13 and suppresses growth and invasion of pancreatic cancer

MicroRNA-145 targets MUC13 and suppresses growth and invasion of pancreatic cancer

https://doi.org/10.18632/oncotarget.2281

Sheema Khan, Mara C. Ebeling, Mohd S. Zaman, Mohammed Sikander, Murali M. Yallapu, Neeraj Chauhan, Ashley M. Yacoubian, Stephen W. Behrman, Nadeem Zafar, Deepak Kumar, Paul A. Thompson, Meena Jaggi,  and Subhash C. Chauhan
7599-7609
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Silencing of miRNA-148a by hypermethylation activates the integrin-mediated signaling pathway in nasopharyngeal carcinoma

Silencing of miRNA-148a by hypermethylation activates the integrin-mediated signaling pathway in nasopharyngeal carcinoma

https://doi.org/10.18632/oncotarget.2282

Hsin-Pai Li, Hsin-Yi Huang, Yi-Ru Lai, Jing-Xuan Huang, Kai-Ping Chang, Chuen Hsueh,  and Yu-Sun Chang
7610-7624
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

N-Myc-induced up-regulation of TRPM6/TRPM7 channels promotes neuroblastoma cell proliferation

N-Myc-induced up-regulation of TRPM6/TRPM7 channels promotes neuroblastoma cell proliferation

https://doi.org/10.18632/oncotarget.2283

Zheng Zhang, Malika Faouzi, Junhao Huang, Dirk Geerts, Haijie Yu, Andrea Fleig,  and Reinhold Penner
7625-7634
Abstract  |  PDF  |  HTML  |  Order a Reprint

Selective targeting of KRAS-Mutant cells by miR-126 through repression of multiple genes essential for the survival of KRAS-Mutant cells

Selective targeting of KRAS-Mutant cells by miR-126 through repression of multiple genes essential for the survival of KRAS-Mutant cells

https://doi.org/10.18632/oncotarget.2284

Toshifumi Hara, Matthew F. Jones, Murugan Subramanian, Xiao Ling Li, Oliver Ou, Yuelin Zhu, Yuan Yang, Lalage M. Wakefield, Perwez S. Hussain, Jochen Gaedcke, Thomas Ried, Ji Luo, Natasha J. Caplen,  and Ashish Lal
7635-7650
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MicroRNA-mediated down-regulation of NKG2D ligands contributes to glioma immune escape

MicroRNA-mediated down-regulation of NKG2D ligands contributes to glioma immune escape

https://doi.org/10.18632/oncotarget.2287

Paula Codo, Michael Weller, Gunter Meister, Emese Szabo, Alexander Steinle, Marietta Wolter, Guido Reifenberger,  and Patrick Roth
7651-7662
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

CLDN3 inhibits cancer aggressiveness via Wnt-EMT signaling and is a potential prognostic biomarker for hepatocellular carcinoma

CLDN3 inhibits cancer aggressiveness via Wnt-EMT signaling and is a potential prognostic biomarker for hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.2288

Lei Jiang, Yi-Dong Yang, Li Fu, Weiqi Xu, Dabin Liu, Qiaoyi Liang, Xiang Zhang, Lixia Xu, Xin-Yuan Guan, Bin Wu, Joseph J.Y. Sung,  and Jun Yu
7663-7676
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A central role for TRPS1 in the control of cell cycle and cancer development

A central role for TRPS1 in the control of cell cycle and cancer development

https://doi.org/10.18632/oncotarget.2291

Lele Wu, Yuzhi Wang, Yan Liu, Shiyi Yu, Hao Xie, Xingjuan Shi, Sheng Qin, Fei Ma, Tuan Zea Tan, Jean Paul Thiery,  and Liming Chen
7677-7690
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Targeting RNA transcription and translation in ovarian cancer cells with pharmacological inhibitor CDKI-73

Targeting RNA transcription and translation in ovarian cancer cells with pharmacological inhibitor CDKI-73

https://doi.org/10.18632/oncotarget.2296

Frankie Lam, Abdullahi Y. Abbas, Hao Shao, Theodosia Teo, Julian Adams, Peng Li, Tracey D. Bradshaw, Peter M. Fischer, Elisabeth Walsby, Chris Pepper, Yi Chen, Jian Ding,  and Shudong Wang
7691-7704
Abstract  |  PDF  |  HTML  |  Order a Reprint

Expression and functions of galectin-7 in ovarian cancer

Expression and functions of galectin-7 in ovarian cancer

https://doi.org/10.18632/oncotarget.2299

Marilyne Labrie, Maria Claudia Vladoiu, Andrée-Anne Grosset, Louis Gaboury,  and Yves St-Pierre
7705-7721
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Metabolic effect of TAp63α: enhanced glycolysis and pentose phosphate pathway, resulting in increased antioxidant defense

Metabolic effect of TAp63α: enhanced glycolysis and pentose phosphate pathway, resulting in increased antioxidant defense

https://doi.org/10.18632/oncotarget.2300

Angelo D’Alessandro, Ivano Amelio, Celia R. Berkers, Alexey Antonov, Karen H. Vousden, Gerry Melino,  and Lello Zolla
7722-7733
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Amphipathic tail-anchoring peptide is a promising therapeutic agent for prostate cancer treatment

Amphipathic tail-anchoring peptide is a promising therapeutic agent for prostate cancer treatment

https://doi.org/10.18632/oncotarget.2301

Gejing De, Jae-Kyun Ko, Tao Tan, Hua Zhu, Haichang Li,  and Jianjie Ma
7734-7747
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The microRNA-23b/27b/24-1 cluster is a disease progression marker and tumor suppressor in prostate cancer

The microRNA-23b/27b/24-1 cluster is a disease progression marker and tumor suppressor in prostate cancer

https://doi.org/10.18632/oncotarget.2294

Yusuke Goto, Satoko Kojima, Rika Nishikawa, Hideki Enokida, Takeshi Chiyomaru, Takashi Kinoshita, Masayuki Nakagawa, Yukio Naya, Tomohiko Ichikawa,  and Naohiko Seki
7748-7759
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Overexpression of secretagogin inhibits cell apoptosis and induces chemoresistance in small cell lung cancer under the regulation of miR-494

Overexpression of secretagogin inhibits cell apoptosis and induces chemoresistance in small cell lung cancer under the regulation of miR-494

https://doi.org/10.18632/oncotarget.2305

Yifeng Bai, Yanqin Sun, Juan Peng, Hongzhan Liao, Hongyi Gao, Ying Guo,  and Linlang Guo
7760-7775
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Annexin A4 induces platinum resistance in a chloride-and calcium-dependent manner

Annexin A4 induces platinum resistance in a chloride-and calcium-dependent manner

https://doi.org/10.18632/oncotarget.2306

Akiko Morimoto, Satoshi Serada, Takayuki Enomoto, Ayako Kim, Shinya Matsuzaki, Tsuyoshi Takahashi, Yutaka Ueda, Kiyoshi Yoshino, Masami Fujita, Minoru Fujimoto, Tadashi Kimura,  and Tetsuji Naka
7776-7787
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The novel Aryl hydrocarbon receptor inhibitor biseugenol inhibits gastric tumor growth and peritoneal dissemination

The novel Aryl hydrocarbon receptor inhibitor biseugenol inhibits gastric tumor growth and peritoneal dissemination

https://doi.org/10.18632/oncotarget.2307

De-Wei Lai, Shing-Hwa Liu, Anna Isabella Karlsson, Wen-Jane Lee, Keh-Bin Wang, Yi-Ching Chen, Chin-Chang Shen, Sheng-Mao Wu, Chia-Yu Liu, Hsing-Ru Tien, Yen-Chun Peng, Yee-Jee Jan, Te-Hsin Chao, Keng-Hsin Lan, Jack L. Arbiser,  and Meei-Ling Sheu
7788-7804
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Clusterin inhibition using OGX-011 synergistically enhances zoledronic acid activity in osteosarcoma

Clusterin inhibition using OGX-011 synergistically enhances zoledronic acid activity in osteosarcoma

https://doi.org/10.18632/oncotarget.2308

Francois Lamoureux, Marc Baud’huin, Benjamin Ory, Romain Guiho, Amina Zoubeidi, Martin Gleave, Dominique Heymann,  and Françoise Rédini
7805-7819
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Neddylation pathway is up-regulated in human intrahepatic cholangiocarcinoma and serves as a potential therapeutic target

Neddylation pathway is up-regulated in human intrahepatic cholangiocarcinoma and serves as a potential therapeutic target

https://doi.org/10.18632/oncotarget.2309

Qiang Gao, Guang-Yang Yu, Jie-Yi Shi, Li-Hui Li, Wen-Juan Zhang, Zhi-Chao Wang, Liu-Xiao Yang, Meng Duan, Hu Zhao, Xiao-Ying Wang, Jian Zhou, Shuang-Jian Qiu, Lak Shin Jeong, Li-Jun Jia,  and Jia Fan
7820-7832
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Co-ordination of cell cycle, migration and stem cell-like activity in breast cancer

Co-ordination of cell cycle, migration and stem cell-like activity in breast cancer

https://doi.org/10.18632/oncotarget.2312

Rebecca Lamb, Michael P. Lisanti, Robert B. Clarke,  and Göran Landberg
7833-7842
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A highly efficient tumor-infiltrating MDSC differentiation system for discovery of anti-neoplastic targets, which circumvents the need for tumor establishment in mice

A highly efficient tumor-infiltrating MDSC differentiation system for discovery of anti-neoplastic targets, which circumvents the need for tumor establishment in mice

https://doi.org/10.18632/oncotarget.2279

Therese Liechtenstein, Noemi Perez-Janices, Maria Gato, Fabio Caliendo, Grazyna Kochan, Idoia Blanco-Luquin, Frederick Arce, David Guerrero-Setas, Joaquin Fernandez-Irigoyen, Enrique Santamaria, Karine Breckpot,  and David Escors
7843-7857
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

­Integrated analysis of epigenomic and genomic changes by DNA methylation dependent mechanisms provides potential novel biomarkers for prostate cancer

­Integrated analysis of epigenomic and genomic changes by DNA methylation dependent mechanisms provides potential novel biomarkers for prostate cancer

https://doi.org/10.18632/oncotarget.2313

Nicole M. A. White-Al Habeeb, Linh T. Ho, Ekaterina Olkhov-Mitsel, Ken Kron, Vaijayanti Pethe, Melanie Lehman, Lidija Jovanovic, Neil Fleshner, Theodorus van der Kwast, Colleen C. Nelson,  and Bharati Bapat
7858-7869
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Fucoidan inhibition of lung cancer in vivo and in vitro : role of the Smurf2-dependent ubiquitin proteasome pathway in TGFβ receptor degradation

Fucoidan inhibition of lung cancer in vivo and in vitro : role of the Smurf2-dependent ubiquitin proteasome pathway in TGFβ receptor degradation

https://doi.org/10.18632/oncotarget.2317

Hsien-Yeh Hsu, Tung-Yi Lin, Yu-Chung Wu, Shu-Ming Tsao, Pai-An Hwang, Yu-Wei Shih,  and Jason Hsu
7870-7885
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Assessment of the effect of sphingosine kinase inhibitors on apoptosis,unfolded protein response and autophagy of T-cell acute lymphoblastic leukemia cells; indications for novel therapeutics

Assessment of the effect of sphingosine kinase inhibitors on apoptosis,unfolded protein response and autophagy of T-cell acute lymphoblastic leukemia cells; indications for novel therapeutics

https://doi.org/10.18632/oncotarget.2318

Cecilia Evangelisti, Camilla Evangelisti, Gabriella Teti, Francesca Chiarini, Mirella Falconi, Fraia Melchionda, Andrea Pession, Alice Bertaina, Franco Locatelli, James A. McCubrey, Dong Jae Beak, Robert Bittman, Susan Pyne, Nigel J. Pyne,  and Alberto M. Martelli
7886-7901
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

miR-200c overexpression is associated with better efficacy of EGFR-TKIs in non-small cell lung cancer patients with EGFR wild-type

miR-200c overexpression is associated with better efficacy of EGFR-TKIs in non-small cell lung cancer patients with EGFR wild-type

https://doi.org/10.18632/oncotarget.2302

Jiayu Li, Xuefei Li, Shengxiang Ren, Xiaoxia Chen, Yishi Zhang, Fei Zhou, Mingchuan Zhao, Chao Zhao, Xiu Chen, Ningning Cheng, Yinmin Zhao, Caicun Zhou,  and Fred R. Hirsch
7902-7916
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Estrogen receptor alpha prevents bladder cancer via INPP4B inhibited akt pathway in vitro and in vivo

Estrogen receptor alpha prevents bladder cancer via INPP4B inhibited akt pathway in vitro and in vivo

https://doi.org/10.18632/oncotarget.1421

Iawen Hsu, Chiuan-Ren Yeh, Spencer Slavin, Hiroshi Miyamoto, George Netto, Yu-Chieh Tsai, Mesut Muyan, Xue-Ru Wu,  and Shuyuan Yeh
7917-7935
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Mutant NRASQ61 shares signaling similarities across various cancer types – potential implications for future therapies

Mutant NRASQ61 shares signaling similarities across various cancer types – potential implications for future therapies

https://doi.org/10.18632/oncotarget.2326

Igor Vujic, Christian Posch, Martina Sanlorenzo, Adam J. Yen, Aaron Tsumura, Andrew Kwong, Valentin Feichtenschlager, Kevin Lai, Douglas V. Arneson, Klemens Rappersberger,  and Susana M. Ortiz-Urda
7936-7944
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

FAK Inhibition with Small Molecule Inhibitor Y15 Decreases Viability, Clonogenicity, and Cell Attachment in Thyroid Cancer Cell Lines and Synergizes with Targeted Therapeutics

FAK Inhibition with Small Molecule Inhibitor Y15 Decreases Viability, Clonogenicity, and Cell Attachment in Thyroid Cancer Cell Lines and Synergizes with Targeted Therapeutics

https://doi.org/10.18632/oncotarget.2381

Shalana O’Brien, Vita M. Golubovskaya, Jeffrey Conroy, Song Liu, Dan Wang, Biao Liu,  and William G. Cance
7945-7959
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Mutations in CIC and IDH1 cooperatively regulate 2-hydroxyglutarate levels and cell clonogenicity

Mutations in CIC and IDH1 cooperatively regulate 2-hydroxyglutarate levels and cell clonogenicity

https://doi.org/10.18632/oncotarget.2401

Suganthi Chittaranjan, Susanna Chan, Cindy Yang, Kevin C. Yang, Vincent Chen, Annie Moradian, Marlo Firme, Jungeun Song, Nancy E. Go, Michael D. Blough, Jennifer A. Chan, Gregory J. Cairncross, Sharon M. Gorski, Gregg B. Morin, Stephen Yip,  and Marco A. Marra
7960-7979
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