Oncotarget

Vol 5, No 15

August 15, 2014

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About The Cover

SHP2 silencing prevents splenomegaly in a mouse model of SM. Representative images of spleens isolated from DBA/2 mice at day 13 following retro-orbital injection of saline (sham), or P815-NT cells, or P815-KD cells. See Sharma et al.

Table of Contents

Editorial News

Spy'ing on differentiation in neuroblastoma.

Spy'ing on differentiation in neuroblastoma.

https://doi.org/10.18632/oncotarget.2325

Monika Podkowa,  and Meredith S. Irwin
5848-5849
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Editorial

NSCLC metastasis: going with ELMO3

NSCLC metastasis: going with ELMO3

https://doi.org/10.18632/oncotarget.2341

Marie-Anne Goyette,  and Jean-François Côté
5850-5851
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Reviews

Cannabinoids as therapeutic agents in cancer: current status and future implications

Cannabinoids as therapeutic agents in cancer: current status and future implications

https://doi.org/10.18632/oncotarget.2233

Bandana Chakravarti, Janani Ravi,  and Ramesh K. Ganju
5852-5872
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The NF1 gene revisited – from bench to bedside

The NF1 gene revisited – from bench to bedside

https://doi.org/10.18632/oncotarget.2194

Yoon-Sim Yap, John R. McPherson, Choon-Kiat Ong, Steven G. Rozen, Bin-Tean Teh, Ann S. G. Lee,  and David F. Callen
5873-5892
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Research Papers

Eradication of metastatic melanoma through cooperative expression of RNA-based HDAC1 inhibitor and p73 by oncolytic adenovirus

Eradication of metastatic melanoma through cooperative expression of RNA-based HDAC1 inhibitor and p73 by oncolytic adenovirus

https://doi.org/10.18632/oncotarget.1839

Holger Schipper, Vijay Alla, Claudia Meier, Dirk M. Nettelbeck, Ottmar Herchenröder,  and Brigitte M. Pützer
5893-5907
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FGFR1 activation is an escape mechanism in human lung cancer cells resistant to afatinib, a pan-EGFR family kinase inhibitor

FGFR1 activation is an escape mechanism in human lung cancer cells resistant to afatinib, a pan-EGFR family kinase inhibitor

https://doi.org/10.18632/oncotarget.1866

Koichi Azuma, Akihiko Kawahara, Kahori Sonoda, Kazutaka Nakashima, Kousuke Tashiro, Kosuke Watari, Hiroto Izumi, Masayoshi Kage, Michihiko Kuwano, Mayumi Ono,  and Tomoaki Hoshino
5908-5919
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SPHK1 regulates proliferation and survival responses in triple-negative breast cancer

SPHK1 regulates proliferation and survival responses in triple-negative breast cancer

https://doi.org/10.18632/oncotarget.1874

Arpita Datta, Ser Yue Loo, Baohua Huang, Lingkai Wong, Sheryl S.L. Tan, Tuan Zea Tan, Soo-Chin Lee, Jean Paul Thiery, Yaw Chyn Lim, Wei Peng Yong, Yulin Lam, Alan Prem Kumar,  and Celestial T. Yap
5920-5933
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Anti-neoplastic properties of hydralazine in prostate cancer

Anti-neoplastic properties of hydralazine in prostate cancer

https://doi.org/10.18632/oncotarget.1909

Inês Graça, Elsa J. Sousa, Pedro Costa-Pinheiro, Filipa Q. Vieira, Jorge Torres-Ferreira, Maria Gabriela Martins, Rui Henrique,  and Carmen Jerónimo
5950-5964
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Identification of a gene expression driven progression pathway in myxoid liposarcoma

Identification of a gene expression driven progression pathway in myxoid liposarcoma

https://doi.org/10.18632/oncotarget.2023

Loris De Cecco, Tiziana Negri, Silvia Brich, Valentina Mauro, Fabio Bozzi, GianPaolo Dagrada, Vittoria Disciglio, Roberta Sanfilippo, Alessandro Gronchi, Maurizio D’Incalci, Paolo G. Casali, Silvana Canevari, Marco A. Pierotti,  and Silvana Pilotti
5965-5977
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A novel copper(I) complex induces ER-stress-mediated apoptosis and sensitizes B-acute lymphoblastic leukemia cells to chemotherapeutic agents

A novel copper(I) complex induces ER-stress-mediated apoptosis and sensitizes B-acute lymphoblastic leukemia cells to chemotherapeutic agents

https://doi.org/10.18632/oncotarget.2027

Roberta Bortolozzi, Giampietro Viola, Elena Porcù, Francesca Consolaro, Cristina Marzano, Maura Pellei, Valentina Gandin,  and Giuseppe Basso
5978-5991
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The stress phenotype makes cancer cells addicted to CDT2, a substrate receptor of the CRL4 ubiquitin ligase

The stress phenotype makes cancer cells addicted to CDT2, a substrate receptor of the CRL4 ubiquitin ligase

https://doi.org/10.18632/oncotarget.2042

Martina Olivero, Daniela Dettori, Sabrina Arena, Davide Zecchin, Erica Lantelme,  and Maria Flavia Di Renzo
5992-6002
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Somatic intronic microsatellite loci differentiate glioblastoma from lower-grade gliomas

Somatic intronic microsatellite loci differentiate glioblastoma from lower-grade gliomas

https://doi.org/10.18632/oncotarget.2076

Enusha Karunasena, Lauren J. McIver, Brian R. Rood, Xiaowei Wu, Hongxiao Zhu, Jasmin H. Bavarva,  and Harold R. Garner
6003-6014
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Loss of 4E-BP1 function induces EMT and promotes cancer cell migration and invasion via cap-dependent translational activation of snail

Loss of 4E-BP1 function induces EMT and promotes cancer cell migration and invasion via cap-dependent translational activation of snail

https://doi.org/10.18632/oncotarget.2109

Weijia Cai, Qing Ye,  and Qing-Bai She
6015-6027
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

4EGI-1 targets breast cancer stem cells by selective inhibition of translation that persists in CSC maintenance, proliferation and metastasis

4EGI-1 targets breast cancer stem cells by selective inhibition of translation that persists in CSC maintenance, proliferation and metastasis

https://doi.org/10.18632/oncotarget.2112

Tingfang Yi, Eihab Kabha, Evangelos Papadopoulos,  and Gerhard Wagner
6028-6037
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PTK6/BRK is expressed in the normal mammary gland and activated at the plasma membrane in breast tumors

PTK6/BRK is expressed in the normal mammary gland and activated at the plasma membrane in breast tumors

https://doi.org/10.18632/oncotarget.2153

Maoyu Peng, Rajyasree Emmadi, Zebin Wang, Elizabeth L. Wiley, Peter H. Gann, Seema A. Khan, Nilanjana Banerji, William McDonald, Szilard Asztalos, Thao N.D. Pham, Debra A. Tonetti,  and Angela L. Tyner
6038-6048
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MicroRNA-101 targets EZH2, MCL-1 and FOS to suppress proliferation, invasion and stem cell-like phenotype of aggressive endometrial cancer cells

MicroRNA-101 targets EZH2, MCL-1 and FOS to suppress proliferation, invasion and stem cell-like phenotype of aggressive endometrial cancer cells

https://doi.org/10.18632/oncotarget.2157

Yosuke Konno, Peixin Dong, Ying Xiong, Fumihiko Suzuki, Jiabin Lu, Muyan Cai, Hidemichi Watari, Takashi Mitamura, Masayoshi Hosaka, Sharon J. B. Hanley, Masataka Kudo,  and Noriaki Sakuragi
6049-6062
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Dietary energy balance modulates ovarian cancer progression and metastasis

Dietary energy balance modulates ovarian cancer progression and metastasis

https://doi.org/10.18632/oncotarget.2168

Zaid Al-Wahab, Calvin Tebbe, Jasdeep Chhina, Sajad A. Dar, Robert T. Morris, Rouba Ali-Fehmi, Shailendra Giri, Adnan R. Munkarah,  and Ramandeep Rattan
6063-6075
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Anti-apoptotic Effects of PCP4/PEP19 in Human Breast Cancer Cell Lines: A Novel Oncotarget

Anti-apoptotic Effects of PCP4/PEP19 in Human Breast Cancer Cell Lines: A Novel Oncotarget

https://doi.org/10.18632/oncotarget.2161

Taiji Hamada, Masakazu Souda, Takuya Yoshimura, Shoko Sasaguri, Kazuhito Hatanaka, Takashi Tasaki, Takako Yoshioka, Yasuyo Ohi, Sohsuke Yamada, Masato Tsutsui, Yoshihisa Umekita,  and Akihide Tanimoto
6076-6086
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Discovery of selective inhibitors of Glutaminase-2, which inhibit mTORC1, activate autophagy and inhibit proliferation in cancer cells

Discovery of selective inhibitors of Glutaminase-2, which inhibit mTORC1, activate autophagy and inhibit proliferation in cancer cells

https://doi.org/10.18632/oncotarget.2173

Yue-Zhi Lee, Cheng-Wei Yang, Hsin-Yu Chang, Hsing-Yu Hsu, Ih-Shen Chen, Hsun-Shuo Chang, Chih-Hao Lee, Jinq-chyi Lee, Chidambaram Ramesh Kumar, Ya-Qi Qiu, Yu-Sheng Chao,  and Shiow-Ju Lee
6087-6101
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Selective inhibitors of nuclear export (SINE) as novel therapeutics for prostate cancer

Selective inhibitors of nuclear export (SINE) as novel therapeutics for prostate cancer

https://doi.org/10.18632/oncotarget.2174

Janet Mendonca, Anup Sharma, Hae-Soo Kim, Hans Hammers, Alan Meeker, Angelo De Marzo, Michael Carducci, Michael Kauffman, Sharon Shacham,  and Sushant Kachhap
6102-6112
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Acquisition of radioresistance in docetaxel-resistant human lung adenocarcinoma cells is linked with dysregulation of miR-451/c-Myc-survivin/rad-51 signaling

Acquisition of radioresistance in docetaxel-resistant human lung adenocarcinoma cells is linked with dysregulation of miR-451/c-Myc-survivin/rad-51 signaling

https://doi.org/10.18632/oncotarget.2176

Rui Wang, Dong-Qin Chen, Jia-Yuan Huang, Kai Zhang, Bing Feng, Ban-Zhou Pan, Jing Chen, Wei De,  and Long-Bang Chen
6113-6129
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Oncogenic KIT-induced aggressive systemic mastocytosis requires SHP2/PTPN11 phosphatase for disease progression in mice

Oncogenic KIT-induced aggressive systemic mastocytosis requires SHP2/PTPN11 phosphatase for disease progression in mice

https://doi.org/10.18632/oncotarget.2177

Namit Sharma, Stephanie Everingham, Li-Fan Zeng, Zhong-Yin Zhang, Reuben Kapur,  and Andrew W.B. Craig
6130-6141
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

AKT regulates NPM dependent ARF localization and p53mut stability in tumors

AKT regulates NPM dependent ARF localization and p53mut stability in tumors

https://doi.org/10.18632/oncotarget.2178

Garth Hamilton, Aswin G. Abraham, Jennifer Morton, Oliver Sampson, Dafni E. Pefani, Svetlana Khoronenkova, Anna Grawenda, Angelos Papaspyropoulos, Nigel Jamieson, Colin McKay, Owen Sansom, Grigory L. Dianov,  and Eric O’Neill
6142-6167
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Top associated SNPs in prostate cancer are significantly enriched in cis-expression quantitative trait loci and at transcription factor binding sites

Top associated SNPs in prostate cancer are significantly enriched in cis-expression quantitative trait loci and at transcription factor binding sites

https://doi.org/10.18632/oncotarget.2179

Junfeng Jiang, Peilin Jia, Bairong Shen,  and Zhongming Zhao
6168-6177
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

F-box protein FBXO31 is down-regulated in gastric cancer and negatively regulated by miR-17 and miR-20a

F-box protein FBXO31 is down-regulated in gastric cancer and negatively regulated by miR-17 and miR-20a

https://doi.org/10.18632/oncotarget.2183

Xinchao Zhang, Ye Kong, Xia Xu, Huaixin Xing, Yingjie Zhang, Fengjuan Han, Wenjuan Li, Qing Yang, Jiping Zeng, Jihui Jia,  and Zhifang Liu
6178-6190
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

CD157 enhances malignant pleural mesothelioma aggressiveness and predicts poor clinical outcome

CD157 enhances malignant pleural mesothelioma aggressiveness and predicts poor clinical outcome

https://doi.org/10.18632/oncotarget.2186

Erika Ortolan, Alice Giacomino, Francesca Martinetto, Simona Morone, Nicola Lo Buono, Enza Ferrero, Giorgio Scagliotti, Silvia Novello, Sara Orecchia, Enrico Ruffini, Ida Rapa, Luisella Righi, Marco Volante,  and Ada Funaro
6191-6205
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Microsatellite instability and ploidy status define three categories with distinctive prognostic impact in endometrioid endometrial cancer

Microsatellite instability and ploidy status define three categories with distinctive prognostic impact in endometrioid endometrial cancer

https://doi.org/10.18632/oncotarget.2187

Cristina Bilbao-Sieyro, Raquel Ramírez-Moreno, Germán Rodríguez-González, Orlando Falcón, Laureano León, Santiago Torres, Leandro Fernández, Sergio Alonso, Nicolás Díaz-Chico, Manuel Perucho,  and Juan Carlos Díaz-Chico
6206-6217
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MicroRNA-100 promotes the autophagy of hepatocellular carcinoma cells by inhibiting the expression of mTOR and IGF-1R

MicroRNA-100 promotes the autophagy of hepatocellular carcinoma cells by inhibiting the expression of mTOR and IGF-1R

https://doi.org/10.18632/oncotarget.2189

Yi-Yuan Ge, Qing Shi, Zhi-Yuan Zheng, Jiao Gong, Chunxian Zeng, Jine Yang,  and Shi-Mei Zhuang
6218-6228
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The Aurora-A inhibitor MLN8237 affects multiple mitotic processes and induces dose-dependent mitotic abnormalities and aneuploidy

The Aurora-A inhibitor MLN8237 affects multiple mitotic processes and induces dose-dependent mitotic abnormalities and aneuploidy

https://doi.org/10.18632/oncotarget.2190

Italia Anna Asteriti, Erica Di Cesare, Fabiola De Mattia, Volker Hilsenstein, Beate Neumann, Enrico Cundari, Patrizia Lavia,  and Giulia Guarguaglini
6229-6242
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

SHP-1 is a target of regorafenib in colorectal cancer

SHP-1 is a target of regorafenib in colorectal cancer

https://doi.org/10.18632/oncotarget.2191

Li-Ching Fan, Hao-Wei Teng, Chung-Wai Shiau, Hang Lin, Man-Hsin Hung, Yen-Lin Chen, Jui-Wen Huang, Wei-Tien Tai, Hui-Chuan Yu,  and Kuen-Feng Chen
6243-6251
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The small heat shock protein B8 (HSPB8) confers resistance to bortezomib by promoting autophagic removal of misfolded proteins in multiple myeloma cells

The small heat shock protein B8 (HSPB8) confers resistance to bortezomib by promoting autophagic removal of misfolded proteins in multiple myeloma cells

https://doi.org/10.18632/oncotarget.2193

Mohamed-Amine Hamouda, Nathalie Belhacene, Alexandre Puissant, Pascal Colosetti, Guillaume Robert, Arnaud Jacquel, Bernard Mari, Patrick Auberger,  and Frederic Luciano
6252-6266
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Surgery-induced wound response promotes stem-like and tumor-initiating features of breast cancer cells, via STAT3 signaling

Surgery-induced wound response promotes stem-like and tumor-initiating features of breast cancer cells, via STAT3 signaling

https://doi.org/10.18632/oncotarget.2195

Ilenia Segatto, Stefania Berton, Maura Sonego, Samuele Massarut, Tiziana Perin, Erica Piccoli, Alfonso Colombatti, Andrea Vecchione, Gustavo Baldassarre,  and Barbara Belletti
6267-6279
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MRD assessed by WT1 and NPM1 transcript levels identifies distinct outcomes in AML patients and is influenced by gemtuzumab ozogamicin

MRD assessed by WT1 and NPM1 transcript levels identifies distinct outcomes in AML patients and is influenced by gemtuzumab ozogamicin

https://doi.org/10.18632/oncotarget.2196

Juliette Lambert, Jérôme Lambert, Olivier Nibourel, Cécile Pautas, Sandrine Hayette, Jean-Michel Cayuela, Christine Terré, Philippe Rousselot, Hervé Dombret, Sylvie Chevret, Claude Preudhomme, Sylvie Castaigne,  and Aline Renneville
6280-6288
Abstract  |  PDF  |  HTML  |  Order a Reprint

Loss of PTEN stabilizes the lipid modifying enzyme cytosolic phospholipase A2α via AKT in prostate cancer cells

Loss of PTEN stabilizes the lipid modifying enzyme cytosolic phospholipase A2α via AKT in prostate cancer cells

https://doi.org/10.18632/oncotarget.2198

Soma Vignarajan, Chanlu Xie, Mu Yao, Yuting Sun, Ulla Simanainen, Paul Sved, Tao Liu,  and Qihan Dong
6289-6299
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Cdc6 cooperates with c-Myc to promote genome instability and epithelial to mesenchymal transition (EMT) in zebrafish

Cdc6 cooperates with c-Myc to promote genome instability and epithelial to mesenchymal transition (EMT) in zebrafish

https://doi.org/10.18632/oncotarget.2204

Ching-Hung Chen, Dar-Shong Lin, Chieh-Wen Cheng, Chun-Ju Lin, Yu-Kang Lo, Chueh-Chuan Yen, Alan Yueh-Luen Lee,  and Chung-Der Hsiao
6300-6311
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Thyroid hormone regulates adhesion, migration and matrix metalloproteinase 9 activity via αvβ3 integrin in myeloma cells

Thyroid hormone regulates adhesion, migration and matrix metalloproteinase 9 activity via αvβ3 integrin in myeloma cells

https://doi.org/10.18632/oncotarget.2205

Keren Cohen, Nir Flint, Shachar Shalev, Daniel Erez, Tal Baharal, Paul J. Davis, Aleck Hercbergs, Martin Ellis,  and Osnat Ashur-Fabian
6312-6322
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Chronic treatment with cisplatin induces replication-dependent sister chromatid recombination to confer cisplatin-resistant phenotype in nasopharyngeal carcinoma

Chronic treatment with cisplatin induces replication-dependent sister chromatid recombination to confer cisplatin-resistant phenotype in nasopharyngeal carcinoma

https://doi.org/10.18632/oncotarget.2210

Wen-Pin Su, Sen-Huei Hsu, Cheng-Kuei Wu, Song-Bin Chang, Yi-Ju Lin, Wen-Bin Yang, Jan-Jong Hung, Wen-Tai Chiu, Shun-Fen Tzeng, Yau-Lin Tseng, Jang-Yang Chang, Wu-Chou Su,  and Hungjiun Liaw
6323-6337
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Impact of human MLL/COMPASS and polycomb complexes on the DNA methylome

Impact of human MLL/COMPASS and polycomb complexes on the DNA methylome

https://doi.org/10.18632/oncotarget.2215

Emily L. Putiri, Rochelle L. Tiedemann, Chunsheng Liu, Jeong-Hyeon Choi,  and Keith D. Robertson
6338-6352
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Hypoxia suppresses cylindromatosis (CYLD) expression to promote inflammation in glioblastoma: possible link to acquired resistance to anti-VEGF therapy

Hypoxia suppresses cylindromatosis (CYLD) expression to promote inflammation in glioblastoma: possible link to acquired resistance to anti-VEGF therapy

https://doi.org/10.18632/oncotarget.2216

Jianying Guo, Satoru Shinriki, Yu Su, Takuya Nakamura, Mitsuhiro Hayashi, Yukimoto Tsuda, Yoshitaka Murakami, Masayoshi Tasaki, Takuichiro Hide, Tatsuya Takezaki, Jun-ichi Kuratsu, Satoshi Yamashita, Mitsuharu Ueda, Jian-Dong Li, Yukio Ando,  and Hirofumi Jono
6353-6364
Abstract  |  PDF  |  HTML  |  Order a Reprint

Mitophagy promotes replication of oncolytic Newcastle disease virus by blocking intrinsic apoptosis in lung cancer cells

Mitophagy promotes replication of oncolytic Newcastle disease virus by blocking intrinsic apoptosis in lung cancer cells

https://doi.org/10.18632/oncotarget.2219

Gang Meng, Mao Xia, Diancheng Wang, Aiping Chen, Yongshan Wang, Hongwei Wang, Decai Yu,  and Jiwu Wei
6365-6374
Abstract  |  PDF  |  HTML  |  Order a Reprint

MicroRNA-99a and 100 mediated upregulation of FOXA1 in bladder cancer

MicroRNA-99a and 100 mediated upregulation of FOXA1 in bladder cancer

https://doi.org/10.18632/oncotarget.2221

Ross M. Drayton, Stefan Peter, Katie Myers, Saiful Miah, Ewa Dudziec, Helen E. Bryant,  and James W. F. Catto
6375-6386
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Overexpression of HMGB1 in melanoma predicts patient survival and suppression of HMGB1 induces cell cycle arrest and senescence in association with p21 (Waf1/Cip1) up-regulation via a p53-independent, Sp1-dependent pathway

Overexpression of HMGB1 in melanoma predicts patient survival and suppression of HMGB1 induces cell cycle arrest and senescence in association with p21 (Waf1/Cip1) up-regulation via a p53-independent, Sp1-dependent pathway

https://doi.org/10.18632/oncotarget.2201

Qingling Li, Jie Li, Ting Wen, Weiqi Zeng, Cong Peng, Siyu Yan, Jieqiong Tan, Keda Yang, Shuang Liu, Aiyuan Guo, Chong Zhang, Juan Su, Minghao Jiang, Zhaoqian Liu, Honghao Zhou,  and Xiang Chen
6387-6403
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Targeted ultra-deep sequencing reveals recurrent and mutually exclusive mutations of cancer genes in blastic plasmacytoid dendritic cell neoplasm

Targeted ultra-deep sequencing reveals recurrent and mutually exclusive mutations of cancer genes in blastic plasmacytoid dendritic cell neoplasm

https://doi.org/10.18632/oncotarget.2223

Albrecht Stenzinger, Volker Endris, Nicole Pfarr, Mindaugas Andrulis, Korinna Jöhrens, Frederick Klauschen, Udo Siebolts, Thomas Wolf, Philipp-Sebastian Koch, Miriam Schulz, Wolfgang Hartschuh, Sergij Goerdt, Jochen K. Lennerz, Claudia Wickenhauser, Wolfram Klapper, Ioannis Anagnostopoulos,  and Wilko Weichert
6404-6413
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

FANCD2 re-expression is associated with glioma grade and chemical inhibition of the Fanconi Anaemia pathway sensitises gliomas to chemotherapeutic agents

FANCD2 re-expression is associated with glioma grade and chemical inhibition of the Fanconi Anaemia pathway sensitises gliomas to chemotherapeutic agents

https://doi.org/10.18632/oncotarget.2225

Abhijit A. Patil, Parag Sayal, Marie-Lise Depondt, Ryan D. Beveridge, Anthony Roylance, Deepti H. Kriplani, Katie N. Myers, Angela Cox, David Jellinek, Malee Fernando, Thomas A. Carroll,  and Spencer J. Collis
6414-6424
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The role of homeostatic regulation between tumor suppressor DAB2IP and oncogenic Skp2 in prostate cancer growth

The role of homeostatic regulation between tumor suppressor DAB2IP and oncogenic Skp2 in prostate cancer growth

https://doi.org/10.18632/oncotarget.2228

Yuh-Shyan Tsai, Chen-Li Lai Lai, Chih-Ho Lai, Kai-Hsiung Chang, Kaijie Wu, Shu-Fen Tseng, Ladan Fazli, Martin Gleave, Guanghua Xiao, Leah Gandee, Nima Sharifi, Loredana Moro, Tzong-Shin Tzai,  and Jer-Tsong Hsieh
6425-6436
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A 5-gene classifier from the carcinoma-associated fibroblast transcriptomic profile and clinical outcome in colorectal cancer

A 5-gene classifier from the carcinoma-associated fibroblast transcriptomic profile and clinical outcome in colorectal cancer

https://doi.org/10.18632/oncotarget.2237

Mireia Berdiel-Acer, Antoni Berenguer, Rebeca Sanz-Pamplona, Daniel Cuadras, Xavier Sanjuan, Maria José Paules, Cristina Santos, Ramon Salazar, Victor Moreno, Gabriel Capella, Alberto Villanueva,  and David G. Molleví
6437-6452
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Sensitization of ovarian cancer cells to cisplatin by gold nanoparticles

Sensitization of ovarian cancer cells to cisplatin by gold nanoparticles

https://doi.org/10.18632/oncotarget.2203

Xunhao Xiong, Rochelle R. Arvizo, Sounik Saha, David J. Robertson, Scott McMeekin, Resham Bhattacharya,  and Priyabrata Mukherjee
6453-6465
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

T cell-recruiting triplebody 19-3-19 mediates serial lysis of malignant B-lymphoid cells by a single T cell

T cell-recruiting triplebody 19-3-19 mediates serial lysis of malignant B-lymphoid cells by a single T cell

https://doi.org/10.18632/oncotarget.2238

Claudia C. Roskopf, Christian B. Schiller, Todd A. Braciak, Sebastian Kobold, Ingo A. Schubert, Georg H. Fey, Karl-Peter Hopfner,  and Fuat S. Oduncu
6466-6483
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Therapeutic CK2 inhibition attenuates diverse prosurvival signaling cascades and decreases cell viability in human breast cancer cells

Therapeutic CK2 inhibition attenuates diverse prosurvival signaling cascades and decreases cell viability in human breast cancer cells

https://doi.org/10.18632/oncotarget.2248

G.Kenneth Gray, Braden C. McFarland, Amber L. Rowse, Sara A. Gibson,  and Etty N. Benveniste
6484-6496
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Multifunctional targeting daunorubicin plus quinacrine liposomes, modified by wheat germ agglutinin and tamoxifen, for treating brain glioma and glioma stem cells

Multifunctional targeting daunorubicin plus quinacrine liposomes, modified by wheat germ agglutinin and tamoxifen, for treating brain glioma and glioma stem cells

https://doi.org/10.18632/oncotarget.2267

Xue-Tao Li, Rui-Jun Ju, Xiu-Ying Li, Fan Zeng, Ji-Feng Shi, Lei Liu, Cheng-Xiang Zhang, Meng-Ge Sun, Jin-Ning Lou,  and Wan-Liang Lu
6497-6511
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CDK4/6 inhibitors have potent activity in combination with pathway selective therapeutic agents in models of pancreatic cancer

CDK4/6 inhibitors have potent activity in combination with pathway selective therapeutic agents in models of pancreatic cancer

https://doi.org/10.18632/oncotarget.2270

Jorge Franco, Agnieszka . K. Witkiewicz,  and Erik S. Knudsen
6512-6525
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Treatment of osteosarcoma with microwave thermal ablation to induce immunogenic cell death

Treatment of osteosarcoma with microwave thermal ablation to induce immunogenic cell death

https://doi.org/10.18632/oncotarget.2310

Zhe Yu, Jie Geng, Minghua Zhang, Yong Zhou, Qingyu Fan,  and Jingyuan Chen
6526-6539
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The anti-tumor activator sMEK1 and paclitaxel additively decrease expression of HIF-1α and VEGF via mTORC1-S6K/4E-BP-dependent signaling pathways

The anti-tumor activator sMEK1 and paclitaxel additively decrease expression of HIF-1α and VEGF via mTORC1-S6K/4E-BP-dependent signaling pathways

https://doi.org/10.18632/oncotarget.2119

Boh-Ram Kim, Kyungsil Yoon, Hyun-Jung Byun, Seung Hee Seo, Seung-Hoon Lee,  and Seung Bae Rho
6540-6551
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Nuclear HER4 mediates acquired resistance to trastuzumab and is associated with poor outcome in HER2 positive breast cancer

Nuclear HER4 mediates acquired resistance to trastuzumab and is associated with poor outcome in HER2 positive breast cancer

https://doi.org/10.18632/oncotarget.1904

Siti Norasikin Mohd Nafi, Daniele Generali, Gabriela Kramer-Marek, Merel Gijsen, Carla Strina, Mariarosa Cappelletti, Daniele Andreis, Syed Haider, Ji-Liang Li, Esther Bridges, Jacek Capala, Roxanis Ioannis, Adrian L. Harris,  and Anthony Kong
59934-5949
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