Oncotarget

Vol 5, No 14

July 30, 2014

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Wild-type p110α has more interactions with the nSH2 domain than the oncogenic mutant H1047R. See Gabelli et. al.

Table of Contents

Editorial

Immunogenic cell death inducers as anticancer agents

Immunogenic cell death inducers as anticancer agents

https://doi.org/10.18632/oncotarget.2266

Oliver Kepp, Laura Senovilla,  and Guido Kroemer
5190-5191
Abstract  |  PDF  |  Order a Reprint

Targeting lemurs against cancer metastasis

Targeting lemurs against cancer metastasis

https://doi.org/10.18632/oncotarget.2271

Yichen Xu, Hua Zhang,  and Georgios Giamas
5192-5193
Abstract  |  PDF  |  Order a Reprint

Ras in epidermal proliferation

Ras in epidermal proliferation

https://doi.org/10.18632/oncotarget.2275

Matthias Drosten, Carmen G. Lechuga,  and Mariano Barbacid
5194-5195
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Knowledge-based computational models

Knowledge-based computational models

https://doi.org/10.18632/oncotarget.2276

Wim Verhaegh,  and Anja Van de Stolpe
5196-5197
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Priority Research Papers

Structural basis of nSH2 regulation and lipid binding in PI3Kα

Structural basis of nSH2 regulation and lipid binding in PI3Kα

https://doi.org/10.18632/oncotarget.2263

Michelle S. Miller, Oleg Schmidt-Kittler, David M. Bolduc, Evan T. Brower, Daniele Chaves-Moreira, Marc Allaire, Kenneth W. Kinzler, Ian G. Jennings, Philip E. Thompson, Philip A. Cole, L. Mario Amzel, Bert Vogelstein,  and Sandra B. Gabelli
5198-5208
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Clinical Research Papers

NY-ESO-1 as a potential immunotherapeutic target in renal cell carcinoma

NY-ESO-1 as a potential immunotherapeutic target in renal cell carcinoma

https://doi.org/10.18632/oncotarget.2101

Eva Giesen, Lucia B. Jilaveanu, Fabio Parisi, Yuval Kluger, Robert L. Camp,  and Harriet M. Kluger
5209-5217
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An epigenetic marker panel for recurrence risk prediction of low grade papillary urothelial cell carcinoma (LGPUCC) and its potential use for surveillance after transurethral resection using urine

An epigenetic marker panel for recurrence risk prediction of low grade papillary urothelial cell carcinoma (LGPUCC) and its potential use for surveillance after transurethral resection using urine

https://doi.org/10.18632/oncotarget.2129

Leonel Maldonado, Mariana Brait, Christina Michailidi, Enrico Munari, Tina Driscoll, Luciana Schultz, Trinity Bivalacqua, Mark Schoenberg, David Sidransky, George J. Netto,  and Mohammad Obaidul Hoque
5218-5233
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Low PKCα expression within the MRD-HR stratum defines a new subgroup of childhood T-ALL with very poor outcome

Low PKCα expression within the MRD-HR stratum defines a new subgroup of childhood T-ALL with very poor outcome

https://doi.org/10.18632/oncotarget.2062

Gloria Milani, Paola Rebora, Benedetta Accordi, Luisa Galla, Silvia Bresolin, Gianni Cazzaniga, Barbara Buldini, Rossella Mura, Saverio Ladogana, Eugenia Giraldi, Valentino Conter, Geertruy Te Kronnie, Maria Grazia Valsecchi,  and Giuseppe Basso
5234-5245
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

High circulating hepatocyte growth factor levels associate with epithelial to mesenchymal transition and poor outcome in small cell lung cancer patients

High circulating hepatocyte growth factor levels associate with epithelial to mesenchymal transition and poor outcome in small cell lung cancer patients

https://doi.org/10.18632/oncotarget.2124

Israel Cañadas, Álvaro Taus, Iria González, Xavier Villanueva, Javier Gimeno, Lara Pijuan, Manuel Dómine, Albert Sánchez-Font, Ivan Vollmer, Silvia Menéndez, Oriol Arpí, Sergi Mojal, Federico Rojo, Ana Rovira, Joan Albanell,  and Edurne Arriola
5246-5256
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Research Papers

LASP1 is a novel BCR-ABL substrate and a phosphorylation-dependent binding partner of CRKL in chronic myeloid leukemia

LASP1 is a novel BCR-ABL substrate and a phosphorylation-dependent binding partner of CRKL in chronic myeloid leukemia

https://doi.org/10.18632/oncotarget.2072

Jochen J. Frietsch, Carolin Kastner, Thomas G. P. Grunewald, Hardy Schweigel, Peter Nollau, Janine Ziermann, Joachim H. Clement, Paul La Rosée, Andreas Hochhaus,  and Elke Butt
5257-5271
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

CD271 is an imperfect marker for melanoma initiating cells

CD271 is an imperfect marker for melanoma initiating cells

https://doi.org/10.18632/oncotarget.1967

Yann Cheli, Vanessa F. Bonnazi, Arnaud Jacquel, Maryline Allegra, Gian Marco De Donatis, Philippe Bahadoran, Corine Bertolotto,  and Robert Ballotti
5272-5283
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Circulating miR-148b and miR-133a as biomarkers for breast cancer detection

Circulating miR-148b and miR-133a as biomarkers for breast cancer detection

https://doi.org/10.18632/oncotarget.2014

Jie Shen, Qiang Hu, Michael Schrauder, Li Yan, Dan Wang, Leonardo Medico, Yuqing Guo, Song Yao, Qianqian Zhu, Biao Liu, Maochun Qin, Matthias W. Beckmann, Peter A. Fasching, Reiner Strick, Candace S. Johnson, Christine B. Ambrosone, Hua Zhao,  and Song Liu
5284-5294
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Loss of ARID1A expression sensitizes cancer cells to PI3K- and AKT-inhibition

Loss of ARID1A expression sensitizes cancer cells to PI3K- and AKT-inhibition

https://doi.org/10.18632/oncotarget.2092

Eleftherios P. Samartzis, Katrin Gutsche, Konstantin J. Dedes, Daniel Fink, Manuel Stucki,  and Patrick Imesch
5295-5303
Abstract  |  PDF  |  HTML  |  Order a Reprint

A FcγRIII-engaging bispecific antibody expands the range of HER2-expressing breast tumors eligible to antibody therapy

A FcγRIII-engaging bispecific antibody expands the range of HER2-expressing breast tumors eligible to antibody therapy

https://doi.org/10.18632/oncotarget.2093

Marc Turini, Patrick Chames, Pierre Bruhns, Daniel Baty,  and Brigitte Kerfelec
5304-5319
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Functional genomics identifies novel genes essential for clear cell renal cell carcinoma tumor cell proliferation and migration

Functional genomics identifies novel genes essential for clear cell renal cell carcinoma tumor cell proliferation and migration

https://doi.org/10.18632/oncotarget.2097

Christina A. von Roemeling, Laura A. Marlow, Derek C. Radisky, Austin Rohl, Hege E. Larsen, Johnny Wei, Heather Sasinowska, Heng Zhu, Richard Drake, Maciek Sasinowski, Han W. Tun,  and John A. Copland
5320-5334
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Galectin-4 expression is associated with reduced lymph node metastasis and modulation of Wnt/β-catenin signalling in pancreatic adenocarcinoma

Galectin-4 expression is associated with reduced lymph node metastasis and modulation of Wnt/β-catenin signalling in pancreatic adenocarcinoma

https://doi.org/10.18632/oncotarget.2104

Mina Maftouh, Ana I. Belo, Amir Avan, Niccola Funel, Godefridus J. Peters, Elisa Giovannetti,  and Irma van Die
5335-5349
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Macrophages are recruited to hypoxic tumor areas and acquire a Pro-Angiogenic M2-Polarized phenotype via hypoxic cancer cell derived cytokines Oncostatin M and Eotaxin

Macrophages are recruited to hypoxic tumor areas and acquire a Pro-Angiogenic M2-Polarized phenotype via hypoxic cancer cell derived cytokines Oncostatin M and Eotaxin

https://doi.org/10.18632/oncotarget.2110

Chakrapani Tripathi, Brij Nath Tewari, Ranjana Kumari Kanchan, Khemraj Singh Baghel, Naveen Nautiyal, Richa Shrivastava, Harbeer Kaur, Madan Lal Bramha Bhatt,  and Smrati Bhadauria
5350-5368
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

GRP78 enhances the glutamine metabolism to support cell survival from glucose deficiency by modulating the β-catenin signaling

GRP78 enhances the glutamine metabolism to support cell survival from glucose deficiency by modulating the β-catenin signaling

https://doi.org/10.18632/oncotarget.2105

Zongwei Li, Yingying Wang, Haili Wu, Lichao Zhang, Peng Yang,  and Zhuoyu Li
5369-5380
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Combined therapy with RAD001 e BEZ235 overcomes resistance of PET immortalized cell lines to mTOR inhibition

Combined therapy with RAD001 e BEZ235 overcomes resistance of PET immortalized cell lines to mTOR inhibition

https://doi.org/10.18632/oncotarget.2111

Ilaria Passacantilli, Gabriele Capurso, Livia Archibugi, Sara Calabretta, Sara Caldarola, Fabrizio Loreni, Gianfranco Delle Fave,  and Claudio Sette
5381-5391
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

FOXO1 downregulation contributes to the oncogenic program of primary mediastinal B-cell lymphoma

FOXO1 downregulation contributes to the oncogenic program of primary mediastinal B-cell lymphoma

https://doi.org/10.18632/oncotarget.2107

Linka Xie, Olga Ritz, Frank Leithäuser, Hanfeng Guan, Johanna Färbinger, Clarissa D. Weitzer, Franziska Gehringer, Silke Brüderlein, Karlheinz Holzmann, Marion J. Vogel, Peter Möller, Thomas Wirth,  and Alexey Ushmorov
5392-5402
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Tumor suppressor XAF1 induces apoptosis, inhibits angiogenesis and inhibits tumor growth in hepatocellular carcinoma

Tumor suppressor XAF1 induces apoptosis, inhibits angiogenesis and inhibits tumor growth in hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.2114

Li Ming Zhu, Dong Mei Shi, Qiang Dai, Xiao Jiao Cheng, Wei Yan Yao, Ping Hu Sun, Yan Fei Ding, Min Min Qiao, Yun Lin Wu, Shi Hu Jiang,  and Shui Ping Tu
5403-5415
Abstract  |  PDF  |  HTML  |  Order a Reprint

MiR-143 acts as a tumor suppressor by targeting N-RAS and enhances temozolomide-induced apoptosis in glioma

MiR-143 acts as a tumor suppressor by targeting N-RAS and enhances temozolomide-induced apoptosis in glioma

https://doi.org/10.18632/oncotarget.2116

Lin Wang, Zhu-mei Shi, Cheng-fei Jiang, Xue Liu, Qiu-dan Chen, Xu Qian, Dong-mei Li, Xin Ge, Xie-feng Wang, Ling-Zhi Liu, Yong-ping You, Ning Liu,  and Bing-Hua Jiang
5416-5427
Abstract  |  PDF  |  HTML  |  Order a Reprint

The response of head and neck squamous cell carcinoma to cetuximab treatment depends on Aurora kinase A polymorphism

The response of head and neck squamous cell carcinoma to cetuximab treatment depends on Aurora kinase A polymorphism

https://doi.org/10.18632/oncotarget.2117

Anja Pickhard, Michael Siegl, Alexander Baumann, Maximilian Huhn, Markus Wirth, Rudolf Reiter, Martina Rudelius, Guido Piontek,  and Gero Brockhoff
5428-5438
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Tumor-derived exosomes promote tumor progression and T-cell dysfunction through the regulation of enriched exosomal microRNAs in human nasopharyngeal carcinoma

Tumor-derived exosomes promote tumor progression and T-cell dysfunction through the regulation of enriched exosomal microRNAs in human nasopharyngeal carcinoma

https://doi.org/10.18632/oncotarget.2118

Shu-biao Ye, Ze-Lei Li, Dong-hua Luo, Bi-jun Huang, Yu-Suan Chen, Xiao-shi Zhang, Jun Cui, Yi-xin Zeng,  and Jiang Li
5439-5452
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Clinically used antirheumatic agent auranofin is a proteasomal deubiquitinase inhibitor and inhibits tumor growth

Clinically used antirheumatic agent auranofin is a proteasomal deubiquitinase inhibitor and inhibits tumor growth

https://doi.org/10.18632/oncotarget.2113

Ningning Liu, Xiaofen Li, Hongbiao Huang, Chong Zhao, Siyan Liao, Changshan Yang, Shouting Liu, Wenbin Song, Xiaoyu Lu, Xiaoying Lan, Xin Chen, Songgang Yi, Li Xu, Lili Jiang, Canguo Zhao, Xiaoxian Dong, Ping Zhou, Shujue Li, Shunqing Wang, Xianping Shi, Ping Q. Dou, Xuejun Wang,  and Jinbao Liu
5453-5471
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Triple negative tumors accumulate significantly less methylglyoxal specific adducts than other human breast cancer subtypes

Triple negative tumors accumulate significantly less methylglyoxal specific adducts than other human breast cancer subtypes

https://doi.org/10.18632/oncotarget.2121

Barbara Chiavarina, Marie-Julie Nokin, Florence x Florence Durieux, Elettra Bianchi, Andrei x Andrei Turtoi, Olivier Peulen, Paul Peixoto, Philippe Irigaray, Koji Uchida, Dominique Belpomme, Philippe Delvenne, Vincent Castronovo,  and Akeila Bellahcène
5472-5482
Abstract  |  PDF  |  HTML  |  Order a Reprint

Hedgehog signaling sensitizes Glioma stem cells to endogenous nano-irradiation

Hedgehog signaling sensitizes Glioma stem cells to endogenous nano-irradiation

https://doi.org/10.18632/oncotarget.2123

Agnieszka Morgenroth, Andreas T. J. Vogg, Katja Ermert, Boris Zlatopolskiy,  and Felix M. Mottaghy
5483-5493
Abstract  |  PDF  |  HTML  |  Order a Reprint

A nucleolin-DNMT1 regulatory axis in acute myeloid leukemogenesis

A nucleolin-DNMT1 regulatory axis in acute myeloid leukemogenesis

https://doi.org/10.18632/oncotarget.2131

Na Shen, Fei Yan, Jiuxia Pang, Lai-Chu Wu, Aref Al-Kali, Mark R. Litzow,  and Shujun Liu
5494-5509
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Sustained conditional knockdown reveals intracellular bone sialoprotein as essential for breast cancer skeletal metastasis

Sustained conditional knockdown reveals intracellular bone sialoprotein as essential for breast cancer skeletal metastasis

https://doi.org/10.18632/oncotarget.2132

Marineta Kovacheva, Michael Zepp, Stefan M. Berger,  and Martin R. Berger
5510-5522
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Sensitization of radio-resistant prostate cancer cells with a unique cytolethal distending toxin

Sensitization of radio-resistant prostate cancer cells with a unique cytolethal distending toxin

https://doi.org/10.18632/oncotarget.2133

Chih-Ho Lai, Chia-Shuo Chang, Hsin-Ho Liu, Yuh-Shyan Tsai, Feng-Ming Hsu, Yung-Luen Yu, Cheng-Kuo Lai, Leah Gandee, Rey-Chen Pong, Heng-Wei Hsu, Lan Yu, Debabrata Saha,  and Jer-Tsong Hsieh
5523-5534
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Tumor suppressor p53 negatively regulates glycolysis stimulated by hypoxia through its target RRAD

Tumor suppressor p53 negatively regulates glycolysis stimulated by hypoxia through its target RRAD

https://doi.org/10.18632/oncotarget.2137

Cen Zhang, Juan Liu, Rui Wu, Yingjian Liang, Meihua Lin, Jia Liu, Chang S. Chan, Wenwei Hu,  and Zhaohui Feng
5535-5546
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Hepatocyte growth factor-like protein is required for prostate tumor growth in the TRAMP mouse model

Hepatocyte growth factor-like protein is required for prostate tumor growth in the TRAMP mouse model

https://doi.org/10.18632/oncotarget.2139

Juozas Vasiliauskas, Madison A. Nashu, Peterson Pathrose, Sandra L. Starnes,  and Susan E. Waltz
5547-5558
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Usp5 links suppression of p53 and FAS levels in melanoma to the BRAF pathway

Usp5 links suppression of p53 and FAS levels in melanoma to the BRAF pathway

https://doi.org/10.18632/oncotarget.2140

Harish Potu, Luke F. Peterson, Anupama Pal, Monique Verhaegen, Juxiang Cao, Moshe Talpaz,  and Nicholas J. Donato
5559-5569
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Small interfering RNA (siRNA)-mediated knockdown of macrophage migration inhibitory factor (MIF) suppressed cyclin D1 expression and hepatocellular carcinoma cell proliferation

Small interfering RNA (siRNA)-mediated knockdown of macrophage migration inhibitory factor (MIF) suppressed cyclin D1 expression and hepatocellular carcinoma cell proliferation

https://doi.org/10.18632/oncotarget.2141

Xiao-hui Huang, Wei-hua Jian, Zhao-feng Wu, Jie Zhao, Hua Wang, Wen Li,  and Jin-tang Xia
5570-5580
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Specific delivery of microRNA93 into HBV-replicating hepatocytes downregulates protein expression of liver cancer susceptible gene MICA

Specific delivery of microRNA93 into HBV-replicating hepatocytes downregulates protein expression of liver cancer susceptible gene MICA

https://doi.org/10.18632/oncotarget.2143

Motoko Ohno, Motoyuki Otsuka, Takahiro Kishikawa, Chikako Shibata, Takeshi Yoshikawa, Akemi Takata, Ryosuke Muroyama, Norie Kowatari, Masaya Sato, Naoya Kato, Shun'ichi Kuroda,  and Kazuhiko Koike
5581-5590
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

E3-ligase Skp2 predicts poor prognosis and maintains cancer stem cell pool in nasopharyngeal carcinoma

E3-ligase Skp2 predicts poor prognosis and maintains cancer stem cell pool in nasopharyngeal carcinoma

https://doi.org/10.18632/oncotarget.2149

Jing Wang, Ying Huang, Zhong Guan, Jia-liang Zhang, Hong-kai Su, Wei Zhang, Cai-feng Yue, Min Yan, Su Guan,  and Quentin Qiang Liu
5591-5601
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The tumor suppressive role of NUMB isoform 1 in esophageal squamous cell carcinoma

The tumor suppressive role of NUMB isoform 1 in esophageal squamous cell carcinoma

https://doi.org/10.18632/oncotarget.2136

Junmou Hong, Zhenguo Liu, Hua zhu, Xin Zhang, Yongju Liang, Shiyuan Yao, Fang Wang, Xiaoyun xie, Bo Zhang, Tao Tan, Liwu Fu, Jing Nie,  and Chao Cheng
5602-5614
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Development of replication-competent adenovirus for bladder cancer by controlling adenovirus E1a and E4 gene expression with the survivin promoter

Development of replication-competent adenovirus for bladder cancer by controlling adenovirus E1a and E4 gene expression with the survivin promoter

https://doi.org/10.18632/oncotarget.2151

Ho Kyung Seo, Jeong Bin Seo, Jae-Kook Nam, Kyung-Chae Jeong, Seung-Pil Shin Shin, In-Hoo Kim, Sang Don Lee,  and Sang-Jin Lee
5615-5623
Abstract  |  PDF  |  HTML  |  Order a Reprint

Upregulation of microRNA135a-3p and death receptor 5 plays a critical role in Tanshinone I sensitized prostate cancer cells to TRAIL induced apoptosis

Upregulation of microRNA135a-3p and death receptor 5 plays a critical role in Tanshinone I sensitized prostate cancer cells to TRAIL induced apoptosis

https://doi.org/10.18632/oncotarget.2152

Eun Ah Shin, Eun Jung Sohn, Gunho Won, Jeong-Un Choi, Myongsuk Jeong, Bonglee Kim, Min-Jeong Kim,  and Sung-Hoon Kim
5624-5636
Abstract  |  PDF  |  HTML  |  Order a Reprint

Histone deacetylase inhibitor treatment induces ‘BRCAness’ and synergistic lethality with PARP inhibitor and cisplatin against human triple negative breast cancer cells

Histone deacetylase inhibitor treatment induces ‘BRCAness’ and synergistic lethality with PARP inhibitor and cisplatin against human triple negative breast cancer cells

https://doi.org/10.18632/oncotarget.2154

Kyungsoo Ha, Warren Fiskus, Dong Soon Choi, Srividya Bhaskara, Leandro Cerchietti, Santhana G. T. Devaraj, Bhavin Shah, Sunil Sharma, Jenny C. Chang, Ari M. Melnick, Scott Hiebert,  and Kapil N. Bhalla
5637-5650
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A novel class I HDAC inhibitor, MPT0G030, induces cell apoptosis and differentiation in human colorectal cancer cells via HDAC1/PKCδ and E-cadherin

A novel class I HDAC inhibitor, MPT0G030, induces cell apoptosis and differentiation in human colorectal cancer cells via HDAC1/PKCδ and E-cadherin

https://doi.org/10.18632/oncotarget.2155

Li-Ting Wang, Jing-Ping Liou, Yu-Hsuan Li, Yi-Min Liu, Shiow-Lin Pan,  and Che-Ming Teng
5651-5662
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

TFF1 activates p53 through down-regulation of miR-504 in gastric cancer

TFF1 activates p53 through down-regulation of miR-504 in gastric cancer

https://doi.org/10.18632/oncotarget.2156

Mohammed Soutto, Zheng Chen, Mohamed A. Saleh, Ahmed Katsha, Shoumin Zhu, Alexander Zaika, Abbes Belkhiri,  and Wael El-Rifai
5663-5673
Abstract  |  PDF  |  HTML  |  Order a Reprint

Potentiation of tumor responses to DNA damaging therapy by the selective ATR inhibitor VX-970

Potentiation of tumor responses to DNA damaging therapy by the selective ATR inhibitor VX-970

https://doi.org/10.18632/oncotarget.2158

Amy B. Hall, Dave Newsome, Yuxin Wang, Diane M. Boucher, Brenda Eustace, Yong Gu, Brian Hare, Mac A. Johnson, Howard Li, Sean Milton, Cheryl E. Murphy, Darin Takemoto, Crystal Tolman, Mark Wood, Peter Charlton, Jean-Damien Charrier, Brinley Furey, Julian Golec, Philip M. Reaper,  and John R. Pollard
5674-5685
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Multiple myeloma cell-derived microvesicles are enriched in CD147 expression and enhance tumor cell proliferation

Multiple myeloma cell-derived microvesicles are enriched in CD147 expression and enhance tumor cell proliferation

https://doi.org/10.18632/oncotarget.2159

Bonnie K. Arendt, Denise K. Walters, Xiaosheng Wu, Renee C. Tschumper,  and Diane F. Jelinek
5686-5699
Abstract  |  PDF  |  HTML  |  Order a Reprint

Loss of PPM1A expression enhances invasion and the epithelial-to-mesenchymal transition in bladder cancer by activating the TGF-β/Smad signaling pathway

Loss of PPM1A expression enhances invasion and the epithelial-to-mesenchymal transition in bladder cancer by activating the TGF-β/Smad signaling pathway

https://doi.org/10.18632/oncotarget.2144

Jiang Geng, Jie Fan, Qi Ouyang, Xiaopeng Zhang, Xiaolong Zhang, Juan Yu, Zude Xu, Qianyu Li, Xudong Yao, Xiuping Liu,  and Junhua Zheng
5700-5711
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

FAS/FASL are dysregulated in chordoma and their loss-of-function impairs zebrafish notochord formation

FAS/FASL are dysregulated in chordoma and their loss-of-function impairs zebrafish notochord formation

https://doi.org/10.18632/oncotarget.2145

Luca Ferrari, Anna Pistocchi, Laura Libera, Nicola Boari, Pietro Mortini, Gianfranco Bellipanni, Antonio Giordano, Franco Cotelli,  and Paola Riva
5712-5724
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Regulatory role of miR-142-3p on the functional hepatic cancer stem cell marker CD133

Regulatory role of miR-142-3p on the functional hepatic cancer stem cell marker CD133

https://doi.org/10.18632/oncotarget.2167

Stella Chai, Man Tong, Kai Yu Ng, Pak Shing Kwan, Yuen Piu Chan, Tsun Ming Fung, Terence K. Lee, Nathalie Wong, Dan Xie, Yun-Fei Yuan, Xin-Yuan Guan,  and Stephanie Ma
5725-5735
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

H-Prune through GSK-3β interaction sustains canonical WNT/β-catenin signaling enhancing cancer progression in NSCLC

H-Prune through GSK-3β interaction sustains canonical WNT/β-catenin signaling enhancing cancer progression in NSCLC

https://doi.org/10.18632/oncotarget.2169

Marianeve Carotenuto, Pasqualino De Antonellis, Lucia Liguori, Giovanna Benvenuto, Daniela Magliulo, Alessandro Alonzi, Cecilia Turino, Carmela Attanasio, Valentina Damiani, Anna Maria Bello, Fabiana Vitiello, Rosa Pasquinelli, Luigi Terracciano, Antonella Federico, Alfredo Fusco, Jamie Freeman, Trevor C. Dale, Charles Decraene, Gennaro Chiappetta, Francovito Piantedosi, Cecilia Calabrese,  and Massimo Zollo
5736-5749
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The ALK inhibitor ASP3026 eradicates NPM-ALK+ T-cell anaplastic large-cell lymphoma in vitro and in a systemic xenograft lymphoma model

The ALK inhibitor ASP3026 eradicates NPM-ALK+ T-cell anaplastic large-cell lymphoma in vitro and in a systemic xenograft lymphoma model

https://doi.org/10.18632/oncotarget.2170

Suraj Konnath George, Deeksha Vishwamitra, Roxsan Manshouri, Ping Shi,  and Hesham M. Amin
5750-5763
Abstract  |  PDF  |  HTML  |  Order a Reprint

Dissecting DNA repair in adult high grade gliomas for patient stratification in the post-genomic era

Dissecting DNA repair in adult high grade gliomas for patient stratification in the post-genomic era

https://doi.org/10.18632/oncotarget.2180

Christina Perry, Devika Agarwal, Tarek M. A. Abdel-Fatah, Anbarasu Lourdusamy, Richard Grundy, Dorothee T. Auer, David Walker, Ravi Lakhani, Ian S. Scott, Stephen Chan, Graham Ball,  and Srinivasan Madhusudan
5764-5781
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Thrombospondin 1 promotes an aggressive phenotype through epithelial-to-mesenchymal transition in human melanoma

Thrombospondin 1 promotes an aggressive phenotype through epithelial-to-mesenchymal transition in human melanoma

https://doi.org/10.18632/oncotarget.2164

Aparna Jayachandran, Matthew Anaka, Prashanth Prithviraj, Christopher Hudson, Sonja J. McKeown, Pu-Han Lo, Laura J. Vella, Colin R. Goding, Jonathan Cebon,  and Andreas Behren
5782-5797
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Histone demethylase RBP2 induced by Helicobactor Pylori CagA participates in the malignant transformation of gastric epithelial cells

Histone demethylase RBP2 induced by Helicobactor Pylori CagA participates in the malignant transformation of gastric epithelial cells

https://doi.org/10.18632/oncotarget.2185

Xiuming Liang, Jiping Zeng, Lixiang Wang, Li Shen, Shuyan Li, Lin Ma, Xinyu Ci, Jingya Yu, Mutian Jia, Yundong Sun, Zhifang Liu, Shili Liu, Wenjuan Li, Han Yu, Chunyan Chen,  and Jihui Jia
5798-5807
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Oncogene-mediated regulation of p53 ISGylation and functions

Oncogene-mediated regulation of p53 ISGylation and functions

https://doi.org/10.18632/oncotarget.2199

Yi-Fu Huang,  and Dmitry V. Bulavin
5808-5818
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Novel celastrol derivatives inhibit the growth of hepatocellular carcinoma patient-derived xenografts

Novel celastrol derivatives inhibit the growth of hepatocellular carcinoma patient-derived xenografts

https://doi.org/10.18632/oncotarget.2171

Wei Wei, Song Wu, Xiaolin Wang, Chris Kin-Wai Sun, Xiaoyang Yang, Xinrui Yan, Mei-Sze Chua,  and Samuel So
5819-5831
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HERG1 functions as an oncogene in pancreatic cancer and is downregulated by miR-96

HERG1 functions as an oncogene in pancreatic cancer and is downregulated by miR-96

https://doi.org/10.18632/oncotarget.2200

Jin Feng, Junbo Yu, Xiaolin Pan, Zengliang Li, Zheng Chen, Wenjie Zhang, Bin Wang, Li Yang, Hao Xu, Guoxin Zhang,  and Zekuan Xu
5832-5844
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Research Perspectives

Caspase-2 regulates oncogene-induced senescence

Caspase-2 regulates oncogene-induced senescence

https://doi.org/10.18632/oncotarget.2286

Delphine Gitenay, Hélène Lallet-Daher,  and David Bernard
5845-5847
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