Oncotarget

Vol 5, No 12

June 30, 2014

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Akwasi et al show the computational docking of GANT61 to GLI1 using the known crystal structure of the five zinc finger GLI1-DNA complex.

Table of Contents

Reviews

An updated overview of HPV-associated head and neck carcinomas

An updated overview of HPV-associated head and neck carcinomas

https://doi.org/10.18632/oncotarget.1934

Apostolos Zaravinos
3956-3969
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Research Perspectives

The nutritional phenome of EMT-induced cancer stem-like cells

The nutritional phenome of EMT-induced cancer stem-like cells

https://doi.org/10.18632/oncotarget.2147

Elisabet Cuyàs, Bruna Corominas-Faja,  and Javier A. Menendez
3970-3982
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Priority Research Papers

Influence of tumor microenvironment on prognosis in colorectal cancer: Tissue architecture-dependent signature of endosialin (TEM-1) and associated proteins

Influence of tumor microenvironment on prognosis in colorectal cancer: Tissue architecture-dependent signature of endosialin (TEM-1) and associated proteins

https://doi.org/10.18632/oncotarget.2108

Daniel J. J. O’Shannessy, Elizabeth B. Somers, Lakshmi K. Chandrasekaran, Nicholas C. Nicolaides, Jennifer Bordeaux,  and Mark D. Gustavson
3983-3995
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Combined BRAFV600E- and SRC-inhibition induces apoptosis, evokes an immune response and reduces tumor growth in an immunocompetent orthotopic mouse model of anaplastic thyroid cancer

Combined BRAFV600E- and SRC-inhibition induces apoptosis, evokes an immune response and reduces tumor growth in an immunocompetent orthotopic mouse model of anaplastic thyroid cancer

https://doi.org/10.18632/oncotarget.2130

Pierre Vanden Borre, Viswanath Gunda, David G. McFadden, Peter M. Sadow, Shohreh Varmeh, Maria Bernasconi,  and Sareh Parangi
3996-4010
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An interferon signature identified by RNA-sequencing of mammary tissues varies across the estrous cycle and is predictive of metastasis-free survival

An interferon signature identified by RNA-sequencing of mammary tissues varies across the estrous cycle and is predictive of metastasis-free survival

https://doi.org/10.18632/oncotarget.2148

Antoine M. Snijders, Sasha Langley, Jian-Hua Mao, Sandhya Bhatnagar, Kathleen A. Bjornstad, Chris J. Rosen, Alvin Lo, Yurong Huang, Eleanor A. Blakely, Gary H. Karpen, Mina J. Bissell,  and Andrew J. Wyrobek
4011-4025
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A genome-wide miRNA screen revealed miR-603 as a MGMT-regulating miRNA in glioblastomas

A genome-wide miRNA screen revealed miR-603 as a MGMT-regulating miRNA in glioblastomas

https://doi.org/10.18632/oncotarget.1974

Deepa Kushwaha, Valya Ramakrishnan, Kimberly Ng, Tyler Steed, Thien Nguyen, Diahnn Futalan, Johnny C. Akers, Jann Sarkaria, Tao Jiang, Dipanjan Chowdhury, Bob S. Carter,  and Clark C. Chen
4026-4039
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Clinical Research Papers

Whole genome expression profiling of blood cells in ovarian cancer patients -Prognostic impact of the CYP1B1, MTSS1, NCALD, and NOP14 genes

Whole genome expression profiling of blood cells in ovarian cancer patients -Prognostic impact of the CYP1B1, MTSS1, NCALD, and NOP14 genes

https://doi.org/10.18632/oncotarget.1938

Helena S. Isaksson, Bengt Sorbe,  and Torbjörn K. Nilsson
4040-4049
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Week one FLT-PET response predicts complete remission to R-CHOP and survival in DLBCL

Week one FLT-PET response predicts complete remission to R-CHOP and survival in DLBCL

https://doi.org/10.18632/oncotarget.1990

Ken Herrmann, Andreas K. Buck, Tibor Schuster, Kathrin Abbrederis, Christina Blümel, Ivan Santi, Martina Rudelius, Hans-Jürgen Wester, Christian Peschel, Markus Schwaiger, Tobias Dechow,  and Ulrich Keller
4050-4059
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Potential clinical implications of BRAF mutations in histiocytic proliferations

Potential clinical implications of BRAF mutations in histiocytic proliferations

https://doi.org/10.18632/oncotarget.2061

Anna-Maria Bubolz, Stephanie E. Weissinger, Albrecht Stenzinger, Annette Arndt, Konrad Steinestel, Silke Brüderlein, Holger Cario, Anneli Lubatschofski, Claudia Welke, Ioannis Anagnostopoulos, Thomas F. E. Barth, Ambros J. Beer, Peter Möller, Martin Gottstein, Andreas Viardot,  and Jochen K. Lennerz
4060-4070
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Research Papers

Identification of aurora kinase A as an unfavorable prognostic factor and potential treatment target for metastatic gastrointestinal stromal tumors

Identification of aurora kinase A as an unfavorable prognostic factor and potential treatment target for metastatic gastrointestinal stromal tumors

https://doi.org/10.18632/oncotarget.1705

Chun-Nan Yeh, Chueh-Chuan Yen, Yen-Yang Chen, Chi-Tung Cheng, Shih-Chiang Huang, Ting-Wei Chang, Fang-Yi Yao, Yung-Chan Lin, Yao-Shan Wen, Kun-Chun Chiang, Jen-Shi Chen, Ta-Sen Yeh, Cheng-Hwai Tzeng, Ta-Chung Chao,  and Jonathan A. Fletcher
4071-4086
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Heme-oxygenase-1 implications in cell morphology and the adhesive behavior of prostate cancer cells

Heme-oxygenase-1 implications in cell morphology and the adhesive behavior of prostate cancer cells

https://doi.org/10.18632/oncotarget.1826

Geraldine Gueron, Jimena Giudice, Pia Valacco, Alejandra Paez, Belen Elguero, Martin Toscani, Felipe Jaworski, Federico Coluccio Leskow, Javier Cotignola, Marcelo Marti, Maria Binaghi, Nora Navone,  and Elba Vazquez
4087-4102
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Silencing of LINE-1 retrotransposons contributes to variation in small noncoding RNA expression in human cancer cells

Silencing of LINE-1 retrotransposons contributes to variation in small noncoding RNA expression in human cancer cells

https://doi.org/10.18632/oncotarget.1822

Stephen Ohms,  and Danny Rangasamy
4103-4117
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Artesunate overcomes drug resistance in multiple myeloma by inducing mitochondrial stress and non-caspase apoptosis

Artesunate overcomes drug resistance in multiple myeloma by inducing mitochondrial stress and non-caspase apoptosis

https://doi.org/10.18632/oncotarget.1847

Xenofon Papanikolaou, Sarah Johnson, Tarun Garg, Erming Tian, Ruslana Tytarenko, Qing Zhang, Caleb Stein, Bart Barlogie, Joshua Epstein,  and Christoph Heuck
4118-4128
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Metformin-induced metabolic reprogramming of chemoresistant ALDHbright breast cancer cells

Metformin-induced metabolic reprogramming of chemoresistant ALDHbright breast cancer cells

https://doi.org/10.18632/oncotarget.1864

Mario Cioce, MariaCristina Valerio, Luca Casadei, Claudio Pulito, Andrea Sacconi, Federica Mori, Francesca Biagioni, Cesare Manetti, Paola Muti, Sabrina Strano,  and Giovanni Blandino
4129-4143
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Loss of tumor suppressor mir-203 mediates overexpression of LIM and SH3 Protein 1 (LASP1) in high-risk prostate cancer thereby increasing cell proliferation and migration

Loss of tumor suppressor mir-203 mediates overexpression of LIM and SH3 Protein 1 (LASP1) in high-risk prostate cancer thereby increasing cell proliferation and migration

https://doi.org/10.18632/oncotarget.1928

Amelie Hailer, Thomas GP Grunewald, Martin Orth, Cora Reiss, Burkhard Kneitz, Martin Spahn,  and Elke Butt
4144-4153
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Urokinase receptor promotes ovarian cancer cell dissemination through its 84-95 sequence

Urokinase receptor promotes ovarian cancer cell dissemination through its 84-95 sequence

https://doi.org/10.18632/oncotarget.1930

Katia Bifulco, Giuseppina Votta, Vincenzo Ingangi, Gioconda Di Carluccio, Domenica Rea, Simona Losito, Nunzia Montuori, Pia Ragno, Maria Patrizia Stoppelli, Claudio Arra,  and Maria Vincenza Carriero
4154-4169
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The poison oligonucleotide F10 is highly effective against acute lymphoblastic leukemia while sparing normal hematopoietic cells

The poison oligonucleotide F10 is highly effective against acute lymphoblastic leukemia while sparing normal hematopoietic cells

https://doi.org/10.18632/oncotarget.1937

Timothy S. Pardee, Kristin Stadelman, Jamie Jennings-Gee, David L. Caudell,  and William H. Gmeiner
4170-4179
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Novel combination of mitochondrial division inhibitor 1 (mdivi-1) and platinum agents produces synergistic pro-apoptotic effect in drug resistant tumor cells

Novel combination of mitochondrial division inhibitor 1 (mdivi-1) and platinum agents produces synergistic pro-apoptotic effect in drug resistant tumor cells

https://doi.org/10.18632/oncotarget.1944

Wei Qian, Jingnan Wang, Vera Roginskaya, Lee A. McDermott, Robert P. Edwards, Donna B. Stolz, Fabien Llambi, Douglas R. Green,  and Bennett Van Houten
4180-4194
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Repression of liver colorectal metastasis by the serpin Spn4A a naturally occurring inhibitor of the constitutive secretory proprotein convertases

Repression of liver colorectal metastasis by the serpin Spn4A a naturally occurring inhibitor of the constitutive secretory proprotein convertases

https://doi.org/10.18632/oncotarget.1966

Fatma Sfaxi, Nathalie Scamuffa, Claude Lalou, Jia Ma, Peter Metrakos, Géraldine Siegfried, Hermann Ragg, Andreas Bikfalvi, Fabien Calvo,  and Abdel-Majid Khatib
4195-4210
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SCFβ-TRCP regulates osteoclastogenesis via promoting CYLD ubiquitination

SCFβ-TRCP regulates osteoclastogenesis via promoting CYLD ubiquitination

https://doi.org/10.18632/oncotarget.1971

Xiaomian Wu, Hidefumi Fukushima, Brian J. North, Yoshiyuki Nagaoka, Katsuyuki Nagashima, Feng Deng, Koji Okabe, Hiroyuki Inuzuka,  and Wenyi Wei
4211-4221
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PLC-beta 1 regulates the expression of miR-210 during mithramycin-mediated erythroid differentiation in K562 cells

PLC-beta 1 regulates the expression of miR-210 during mithramycin-mediated erythroid differentiation in K562 cells

https://doi.org/10.18632/oncotarget.1972

Alberto Bavelloni, Alessandro Poli, Roberta Fiume, William Blalock, Alessandro Matteucci, Giulia Ramazzotti, James A. McCubrey, Lucio Cocco,  and Irene Faenza
4222-4231
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Post-translational regulation of COX2 activity by FYN in prostate cancer cells

Post-translational regulation of COX2 activity by FYN in prostate cancer cells

https://doi.org/10.18632/oncotarget.1983

Anna Alexanian, Bradley Miller, Marla Chesnik, Shama Mirza,  and Andrey Sorokin
4232-4243
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Reduced ING1 levels in breast cancer promotes metastasis

Reduced ING1 levels in breast cancer promotes metastasis

https://doi.org/10.18632/oncotarget.1988

Satbir Thakur, Arvind K. Singla, Jie Chen, Uyen Tran, Yang Yang, Carolina Salazar, Anthony Magliocco, Alexander Klimowicz, Frank R. Jirik,  and Karl Riabowol
4244-4256
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Histone deacetylase 2 and N-Myc reduce p53 protein phosphorylation at serine 46 by repressing gene transcription of tumor protein 53-induced nuclear protein 1

Histone deacetylase 2 and N-Myc reduce p53 protein phosphorylation at serine 46 by repressing gene transcription of tumor protein 53-induced nuclear protein 1

https://doi.org/10.18632/oncotarget.1991

Jeyran Shahbazi, Christopher J. Scarlett, Murray D. Norris, Bing Liu, Michelle Haber, Andrew E. Tee, Alice Carrier, Andrew V. Biankin, Wendy B. London, Glenn M. Marshall, Richard B. Lock,  and Tao Liu
4257-4268
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Identification of a ternary protein-complex as a therapeutic target for K-Ras-dependent colon cancer

Identification of a ternary protein-complex as a therapeutic target for K-Ras-dependent colon cancer

https://doi.org/10.18632/oncotarget.2001

Xiaomei Qi, Congying Xie, Songwang Hou, Gang Li, Ning Yin, Lei Dong, Adrienne Lepp, Marla A. Chesnik, Shama P. Mirza, Aniko Szabo, Susan Tsai, Zainab Basir, Shixiu Wu,  and Guan Chen
4269-4282
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Increased Nek1 expression in Renal Cell Carcinoma cells is associated with decreased sensitivity to DNA-damaging treatment

Increased Nek1 expression in Renal Cell Carcinoma cells is associated with decreased sensitivity to DNA-damaging treatment

https://doi.org/10.18632/oncotarget.2005

Yumay Chen, Chi-Fen Chen, Rosaria Polci, Randy Wei, Daniel J. Riley,  and Phang-Lang Chen
4283-4294
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Relevance of IGFBP2 proteolysis in glioma and contribution of the extracellular protease ADAMTS1

Relevance of IGFBP2 proteolysis in glioma and contribution of the extracellular protease ADAMTS1

https://doi.org/10.18632/oncotarget.2009

Estefanía Martino-Echarri, Rubén Fernández-Rodríguez, Joan Josep Bech-Serra, María del Carmen Plaza-Calonge, Noemi Vidal, Carmen Casal, Nuria Colomé, Joan Seoane, Francesc Canals,  and Juan Carlos Rodríguez-Manzaneque
4295-4304
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Cancer stem cells from epithelial ovarian cancer patients privilege oxidative phosphorylation, and resist glucose deprivation

Cancer stem cells from epithelial ovarian cancer patients privilege oxidative phosphorylation, and resist glucose deprivation

https://doi.org/10.18632/oncotarget.2010

Anna Pastò, Chiara Bellio, Giorgia Pilotto, Vincenzo Ciminale, Micol Silic-Benussi, Giulia Guzzo, Andrea Rasola, Chiara Frasson, Giorgia Nardo, Elisabetta Zulato, Maria Ornella Nicoletto, Mariangela Manicone, Stefano Indraccolo,  and Alberto Amadori
4305-4319
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

High nuclear level of Vav1 is a positive prognostic factor in early invasive breast tumors: a role in modulating genes related to the efficiency of metastatic process

High nuclear level of Vav1 is a positive prognostic factor in early invasive breast tumors: a role in modulating genes related to the efficiency of metastatic process

https://doi.org/10.18632/oncotarget.2011

Silvia Grassilli, Federica Brugnoli, Rossano Lattanzio, Cosmo Rossi, Letizia Perracchio, Marcella Mottolese, Marco Marchisio, Maria Palomba, Ervin Nika, Pier Giorgio Natali, Mauro Piantelli, Silvano Capitani,  and Valeria Bertagnolo
4320-4336
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

XIAP inhibitors induce differentiation and impair clonogenic capacity of acute myeloid leukemia stem cells

XIAP inhibitors induce differentiation and impair clonogenic capacity of acute myeloid leukemia stem cells

https://doi.org/10.18632/oncotarget.2016

Daniel Moreno-Martínez, Meritxell Nomdedeu, María Carmen Lara-Castillo, Amaia Etxabe, Marta Pratcorona, Niccolò Tesi, Marina Díaz-Beyá, María Rozman, Emili Montserrat, Álvaro Urbano-Ispizua, Jordi Esteve,  and Ruth M. Risueño
4337-4346
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Sodium dichloroacetate exhibits anti-leukemic activity in B-chronic lymphocytic leukemia (B-CLL) and synergizes with the p53 activator Nutlin-3

Sodium dichloroacetate exhibits anti-leukemic activity in B-chronic lymphocytic leukemia (B-CLL) and synergizes with the p53 activator Nutlin-3

https://doi.org/10.18632/oncotarget.2018

Chiara Agnoletto, Elisabetta Melloni, Fabio Casciano, Gian Matteo Rigolin, Erika Rimondi, Claudio Celeghini, Laura Brunelli, Antonio Cuneo, Paola Secchiero,  and Giorgio Zauli
4347-4360
Abstract  |  PDF  |  HTML  |  Order a Reprint

DNA intercalator BMH-21 inhibits RNA polymerase I independent of DNA damage response

DNA intercalator BMH-21 inhibits RNA polymerase I independent of DNA damage response

https://doi.org/10.18632/oncotarget.2020

Laureen Colis, Karita Peltonen, Paul Sirajuddin, Hester Liu, Sara Sanders, Glen Ernst, James C. Barrow,  and Marikki Laiho
4361-4369
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SCFFBXW7α modulates the intra-S-phase DNA-damage checkpoint by regulating Polo like kinase-1 stability

SCFFBXW7α modulates the intra-S-phase DNA-damage checkpoint by regulating Polo like kinase-1 stability

https://doi.org/10.18632/oncotarget.2021

Servando Giráldez, Joaquín Herrero-Ruiz, Mar Mora-Santos, Miguel Á. Japón, Maria Tortolero,  and Francisco Romero
4370-4383
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Phenotypic and genotypic characterization of azacitidine-sensitive and resistant SKM1 myeloid cell lines

Phenotypic and genotypic characterization of azacitidine-sensitive and resistant SKM1 myeloid cell lines

https://doi.org/10.18632/oncotarget.2024

Thomas Cluzeau, Alix Dubois, Arnaud Jacquel, Frederic Luciano, Aline Renneville, Claude Preudhomme, Jean Michel Karsenti, Nicolas Mounier, Pierre Rohrlich, Sophie Raynaud, Bernard Mari, Guillaume Robert,  and Patrick Auberger
4384-4391
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

NOX4 promotes non-small cell lung cancer cell proliferation and metastasis through positive feedback regulation of PI3K/Akt signaling

NOX4 promotes non-small cell lung cancer cell proliferation and metastasis through positive feedback regulation of PI3K/Akt signaling

https://doi.org/10.18632/oncotarget.2025

Cuixiang Zhang, Tian Lan, Jincai Hou, Juan Li, Rende Fang, Zhicheng Yang, Min Zhang, Jianxun Liu,  and Bing Liu
4392-4405
Abstract  |  PDF  |  HTML  |  Order a Reprint

Rac1 regulates skin tumors by regulation of keratin 17 through recruitment and interaction with CD11b+Gr1+ cells

Rac1 regulates skin tumors by regulation of keratin 17 through recruitment and interaction with CD11b+Gr1+ cells

https://doi.org/10.18632/oncotarget.2030

Rongyi Chen, Meng Fu, Guoxue Zhang, Ying Zhou, Shaojun Zhu, Juanjuan Liu, Dong Wang, Anmei Deng,  and Zhipeng Wang
4406-4417
Abstract  |  PDF  |  HTML  |  Order a Reprint

Thymocyte selection-associated high mobility group box gene (TOX) is aberrantly over-expressed in mycosis fungoides and correlates with poor prognosis

Thymocyte selection-associated high mobility group box gene (TOX) is aberrantly over-expressed in mycosis fungoides and correlates with poor prognosis

https://doi.org/10.18632/oncotarget.2031

Yuanshen Huang, Ivan V. Litvinov, Yang Wang, Ming-Wan Su, Ping Tu, Xiaoyan Jiang, Thomas S. Kupper, Jan P. Dutz, Denis Sasseville,  and Youwen Zhou
4418-4425
Abstract  |  PDF  |  HTML  |  Order a Reprint

Apelin promotes lymphangiogenesis and lymph node metastasis

Apelin promotes lymphangiogenesis and lymph node metastasis

https://doi.org/10.18632/oncotarget.2032

Judit Berta, Mir Alireza Hoda, Viktoria Laszlo, Anita Rozsas, Tamas Garay, Szilvia Torok, Michael Grusch, Walter Berger, Sandor Paku, Ferenc Renyi-Vamos, Bernard Masri, Jozsef Tovari, Marion Groger, Walter Klepetko, Balazs Hegedus,  and Balazs Dome
4426-4437
Abstract  |  PDF  |  HTML  |  Order a Reprint

20(S)-Ginsenoside Rg3 is a novel inhibitor of autophagy and sensitizes hepatocellular carcinoma to doxorubicin

20(S)-Ginsenoside Rg3 is a novel inhibitor of autophagy and sensitizes hepatocellular carcinoma to doxorubicin

https://doi.org/10.18632/oncotarget.2034

Dong-Gun Kim, Kyung Hee Jung, Da-Gyum Lee, Jung-Ho Yoon, Kyeong Sook Choi, Sung Won Kwon, Han-Ming Shen, Michael J. Morgan, Soon-Sun Hong,  and You-Sun Kim
4438-4451
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Wild-type ALK and activating ALK-R1275Q and ALK-F1174L mutations upregulate Myc and initiate tumor formation in murine neural crest progenitor cells

Wild-type ALK and activating ALK-R1275Q and ALK-F1174L mutations upregulate Myc and initiate tumor formation in murine neural crest progenitor cells

https://doi.org/10.18632/oncotarget.2036

Gisèle Montavon, Nicolas Jauquier, Aurélie Coulon, Michel Peuchmaur, Marjorie Flahaut, Katia Balmas Bourloud, Pu Yan, Olivier Delattre, Lukas Sommer, Jean-Marc Joseph, Isabelle Janoueix-Lerosey, Nicole Gross,  and Annick Mühlethaler-Mottet
4452-4466
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Host defense peptides for treatment of colorectal carcinoma – a comparative in vitro and in vivo analysis

Host defense peptides for treatment of colorectal carcinoma – a comparative in vitro and in vivo analysis

https://doi.org/10.18632/oncotarget.2039

Claudia Maletzki, Ulrike Klier, Samuel Marinkovic, Ernst Klar, Jörg Andrä,  and Michael Linnebacher
4467-4479
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

PD2/Paf1 depletion in pancreatic acinar cells promotes acinar-to-ductal metaplasia

PD2/Paf1 depletion in pancreatic acinar cells promotes acinar-to-ductal metaplasia

https://doi.org/10.18632/oncotarget.2041

Parama Dey, Satyanarayana Rachagani, Arokia P. Vaz, Moorthy P. Ponnusamy,  and Surinder K. Batra
4480-4491
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Mode and specificity of binding of the small molecule GANT61 to GLI determines inhibition of GLI-DNA binding

Mode and specificity of binding of the small molecule GANT61 to GLI determines inhibition of GLI-DNA binding

https://doi.org/10.18632/oncotarget.2046

Akwasi Agyeman, Babal K. Jha, Tapati Mazumdar,  and Janet A. Houghton
4492-4503
Abstract  |  PDF  |  HTML  |  Order a Reprint

New histone deacetylase inhibitors improve cisplatin antitumor properties against thoracic cancer cells

New histone deacetylase inhibitors improve cisplatin antitumor properties against thoracic cancer cells

https://doi.org/10.18632/oncotarget.2056

Fabien Gueugnon, Pierre-François Cartron, Cedric Charrier, Philippe Bertrand, Jean-François Fonteneau, Marc Gregoire,  and Christophe Blanquart
4504-4515
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Histone deacetylase inhibitor-temozolomide co-treatment inhibits melanoma growth through suppression of Chemokine (C-C motif) ligand 2-driven signals

Histone deacetylase inhibitor-temozolomide co-treatment inhibits melanoma growth through suppression of Chemokine (C-C motif) ligand 2-driven signals

https://doi.org/10.18632/oncotarget.2065

Laura Gatti, Alexandra Sevko, Michelandrea De Cesare, Noemi Arrighetti, Giacomo Manenti, Emilio Ciusani, Paolo Verderio, Chiara M. Ciniselli, Denis Cominetti, Nives Carenini, Elisabetta Corna, Nadia Zaffaroni, Monica Rodolfo, Licia Rivoltini, Viktor Umansky,  and Paola Perego
4516-4528
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Icotinib antagonizes ABCG2-mediated multidrug resistance, but not the pemetrexed resistance mediated by thymidylate synthase and ABCG2

Icotinib antagonizes ABCG2-mediated multidrug resistance, but not the pemetrexed resistance mediated by thymidylate synthase and ABCG2

https://doi.org/10.18632/oncotarget.2102

De-Shen Wang, Atish Patel, Suneet Shukla, Yun-Kai Zhang, Yi-Jun Wang, Rishil J. Kathawala, Robert W. Robey, Li Zhang, Dong-Hua Yang, Tanaji T. Talele, Susan E. Bates, Suresh V. Ambudkar, Rui-Hua Xu,  and Zhe-Sheng Chen
4529-4542
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Discovery of novel non-ATP competitive FGFR1 inhibitors and evaluation of their anti-tumor activity in non-small cell lung cancer in vitro and in vivo

Discovery of novel non-ATP competitive FGFR1 inhibitors and evaluation of their anti-tumor activity in non-small cell lung cancer in vitro and in vivo

https://doi.org/10.18632/oncotarget.2122

Jianzhang Wu, Jiansong Ji, Bixia Weng, Peihong Qiu, Karvannan Kanchana, Tao Wei, Yi Wang, Yuepiao Cai, Xiaokun Li,  and Guang Liang
4543-4553
Abstract  |  PDF  |  HTML  |  Order a Reprint

Novel inhibitors are cytotoxic for myeloma cells with NFkB inducing kinase-dependent activation of NFkB

Novel inhibitors are cytotoxic for myeloma cells with NFkB inducing kinase-dependent activation of NFkB

https://doi.org/10.18632/oncotarget.2128

Yulia N. Demchenko, Leslie A. Brents, Zhihong Li, Leif P. Bergsagel, Lawrence R. McGee,  and Michael W. Kuehl
4554-4566
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Targeted cytotoxic analog of luteinizing hormone-releasing hormone (LHRH), AEZS-108 (AN-152), inhibits the growth of DU-145 human castration-resistant prostate cancer in vivo and in vitro through elevating p21 and ROS levels

Targeted cytotoxic analog of luteinizing hormone-releasing hormone (LHRH), AEZS-108 (AN-152), inhibits the growth of DU-145 human castration-resistant prostate cancer in vivo and in vitro through elevating p21 and ROS levels

https://doi.org/10.18632/oncotarget.2146

Petra Popovics, Andrew V. Schally, Luca Szalontay, Norman L. Block,  and Ferenc G. Rick
4567-4578
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