Oncotarget

Vol 5, No 9

May 15, 2014

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About The Cover




This issue's cover figure comes from Agrawal et al. titled "Sac-1004 reduces lung and lymph node metastasis in B16BL6 foot-pad metastasis mice model" . Part F shows sections of popliteal lymph nodes were immunostained for LYVE-1 and cytokeratin-18 (melanocyte marker).

Table of Contents

Research Perspectives

Oncobiguanides: Paracelsus’ law and nonconventional routes for administering diabetobiguanides for cancer treatment

Oncobiguanides: Paracelsus’ law and nonconventional routes for administering diabetobiguanides for cancer treatment

https://doi.org/10.18632/oncotarget.1965

Javier A. Menendez, Rosa Quirantes-Piné, Esther Rodríguez-Gallego, Sílvia Cufí, Bruna Corominas-Faja, Elisabet Cuyàs, Joaquim Bosch-Barrera, Begoña Martin-Castillo, Antonio Segura-Carretero,  and Jorge Joven
2344-2348
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Unique molecular signatures as a hallmark of patients with metastatic breast cancer: Implications for current treatment paradigms

Unique molecular signatures as a hallmark of patients with metastatic breast cancer: Implications for current treatment paradigms

https://doi.org/10.18632/oncotarget.1946

Jennifer J. Wheler, Barbara A. Parker, Jack J. Lee, Johnique T. Atkins, Filip Janku, Apostolia M. Tsimberidou, Ralph Zinner, Vivek Subbiah, Siqing Fu, Richard Schwab, Stacy Moulder, Vicente Valero, Maria Schwaederle, Roman Yelensky, Vincent A. Miller, M Philip J. Stephens, Funda Meric-Bernstam,  and Razelle Kurzrock
2349-2354
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Research Papers

Inhibition of BRD4 attenuates tumor cell self-renewal and suppresses stem cell signaling in MYC driven medulloblastoma

Inhibition of BRD4 attenuates tumor cell self-renewal and suppresses stem cell signaling in MYC driven medulloblastoma

https://doi.org/10.18632/oncotarget.1659

Sujatha Venataraman, Irina Alimova, Peter Harris, Diane K Birks, Illango Balakrishnan, Marc Remke, Michael D Taylor, Michael Handler, Nicholas K Foreman,  and Rajeev Vibhakar
2355-2371
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Antitumor activity of the combination of an HSP90 inhibitor and a PI3K/mTOR dual inhibitor against cholangiocarcinoma

Antitumor activity of the combination of an HSP90 inhibitor and a PI3K/mTOR dual inhibitor against cholangiocarcinoma

https://doi.org/10.18632/oncotarget.1706

Ming-Huang Chen, Kun-Chun Chiang, Chi-Tung Cheng, Shih-Chiang Huang, Yeng-Yang Chen, Tsung-Wen Chen, Ta-Sen Yeh, Yi-Yin Jan, Hsi-Ming Wang, Jiang-Jie Weng, Peter Mu-Hsin Chang, Chun-Yu Liu, Chung-Pin Li, Yee Chao, Ming-Han Chen, Chi-Ying F. Huang,  and Chun-Nan Yeh
2372-2389
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The KLK5 protease suppresses breast cancer by repressing the mevalonate pathway

The KLK5 protease suppresses breast cancer by repressing the mevalonate pathway

https://doi.org/10.18632/oncotarget.1235

Georgios Pampalakis, Osahon Obasuyi, Olga Papadodima, Aristotelis Chatziioannou, Vassileios Zoumpourlis,  and Georgia Sotiropoulou
2390-2403
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Alternative splicing of FBP-interacting repressor coordinates c-Myc, P27Kip1/cyclinE and Ku86/XRCC5 expression as a molecular sensor for bleomycin-induced DNA damage pathway

Alternative splicing of FBP-interacting repressor coordinates c-Myc, P27Kip1/cyclinE and Ku86/XRCC5 expression as a molecular sensor for bleomycin-induced DNA damage pathway

https://doi.org/10.18632/oncotarget.1650

Bahityar Rahmutulla, Kazuyuki Matsushita, Mamoru Satoh, Masanori Seimiya, Sachio Tsuchida, Shuji Kubo, Hideaki Shimada, Masayuki Ohtsuka, Masaru Miyazaki,  and Fumio Nomura
2404-2417
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SERPINB3 protects from oxidative damage by chemotherapeutics through inhibition of mitochondrial respiratory complex I

SERPINB3 protects from oxidative damage by chemotherapeutics through inhibition of mitochondrial respiratory complex I

https://doi.org/10.18632/oncotarget.1411

Francesco Ciscato, Marco Sciacovelli, Gianmarco Villano, Cristian Turato, Paolo Bernardi, Andrea Rasola,  and Patrizia Pontisso
2418-2427
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Bak and Mcl-1 are essential for Temozolomide induced cell death in human glioma

Bak and Mcl-1 are essential for Temozolomide induced cell death in human glioma

https://doi.org/10.18632/oncotarget.1642

Catherine Gratas, Quentin Séry, Marion Rabé, Lisa Oliver,  and François M. Vallette
2428-2435
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WT1 regulates angiogenesis in Ewing Sarcoma

WT1 regulates angiogenesis in Ewing Sarcoma

https://doi.org/10.18632/oncotarget.1610

Varalakshimi Katuri, Stephanie Gerber, Xiaofei Qiu, Gregory McCarty, Seth D. Goldstein, Hans Hammers, Elizabeth Montgomery, Allen R. Chen,  and David M. Loeb
2436-2449
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Enrichment of circulating melanoma cells (CMCs) using negative selection from patients with metastatic melanoma.

Enrichment of circulating melanoma cells (CMCs) using negative selection from patients with metastatic melanoma.

https://doi.org/10.18632/oncotarget.1683

Powrnima Joshi, Barbara Jacobs, Adeeb Derakhshan, Lee R. Moore, Paul Elson, Pierre L. Triozzi, Ernest Borden,  and Maciej Zborowski
2450-2461
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YB-1 expression promotes epithelial-to-mesenchymal transition in prostate cancer that is inhibited by a small molecule fisetin

YB-1 expression promotes epithelial-to-mesenchymal transition in prostate cancer that is inhibited by a small molecule fisetin

https://doi.org/10.18632/oncotarget.1790

Mohammad Imran Khan, Vaqar Mustafa Adhami, Rahul Kumar Lall, Mario Sechi, Dinesh C. Joshi, Omar M. Haidar, Deeba Nadeem Syed, Imtiaz Ahmad Siddiqui, Shing-Yan Chiu,  and Hasan Mukhtar
2462-2474
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FAAH inhibition enhances anandamide mediated anti-tumorigenic effects in non-small cell lung cancer by downregulating the EGF/EGFR pathway

FAAH inhibition enhances anandamide mediated anti-tumorigenic effects in non-small cell lung cancer by downregulating the EGF/EGFR pathway

https://doi.org/10.18632/oncotarget.1723

Janani Ravi, Amita Sneh, Konstantin Shilo, Mohd W. Nasser,  and Ramesh K. Ganju
2475-2486
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A DNA repair pathway score predicts survival in human multiple myeloma: the potential for therapeutic strategy

A DNA repair pathway score predicts survival in human multiple myeloma: the potential for therapeutic strategy

https://doi.org/10.18632/oncotarget.1740

Alboukadel Kassambara, Claire Gourzones-Dmitriev, Surinder Sahota, Thierry Rème, Jérôme Moreaux, Hartmut Goldschmidt, Angelos Constantinou, Phillipe Pasero, Dirk Hose,  and Bernard Klein
2487-2498
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A high-content morphological screen identifies novel microRNAs that regulate neuroblastoma cell differentiation

A high-content morphological screen identifies novel microRNAs that regulate neuroblastoma cell differentiation

https://doi.org/10.18632/oncotarget.1703

Zhenze Zhao, Xiuye Ma, Tzu-Hung Hsiao, Gregory Lin, Adam Kosti, Xiaojie Yu, Uthra Suresh, Yidong Chen, Gail E. Tomlinson, Alexander Pertsemlidis,  and Liqin Du
2499-2512
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miR-199a-3p displays tumor suppressor functions in papillary thyroid carcinoma

miR-199a-3p displays tumor suppressor functions in papillary thyroid carcinoma

https://doi.org/10.18632/oncotarget.1830

Emanuela Minna, Paola Romeo, Loris De Cecco, Matteo Dugo, Giuliana Cassinelli, Silvana Pilotti, Debora Degl’Innocenti, Cinzia Lanzi, Patrizia Casalini, Marco A. Pierotti, Angela Greco,  and Maria Grazia Borrello
2513-2528
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STAT3 down regulates LC3 to inhibit autophagy and pancreatic cancer cell growth

STAT3 down regulates LC3 to inhibit autophagy and pancreatic cancer cell growth

https://doi.org/10.18632/oncotarget.1810

Jingjing Gong, Amanda R. Muñoz, Daniel Chan, Rita Ghosh,  and Addanki P. Kumar
2529-2541
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Hyperactivation of Akt/mTOR and deficiency in tuberin increased the oxidative DNA damage in kidney cancer patients with diabetes

Hyperactivation of Akt/mTOR and deficiency in tuberin increased the oxidative DNA damage in kidney cancer patients with diabetes

https://doi.org/10.18632/oncotarget.1833

Samy L. Habib,  and Sitai Liang
2542-2550
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ATRX mRNA expression combined with IDH1/2 mutational status and Ki-67 expression refines the molecular classification of astrocytic tumors: evidence from the whole transcriptome sequencing of 169 samples

ATRX mRNA expression combined with IDH1/2 mutational status and Ki-67 expression refines the molecular classification of astrocytic tumors: evidence from the whole transcriptome sequencing of 169 samples

https://doi.org/10.18632/oncotarget.1838

Jinquan Cai, Pei Yang, Chuanbao Zhang, Wei Zhang, Yanwei Liu, Zhaoshi Bao, Xing Liu, Wenzhong Du, Hongjun Wang, Tao Jiang,  and Chuanlu Jiang
2551-2561
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IGF-1R, a target of let-7b, mediates crosstalk between IRS-2/Akt and MAPK pathways to promote proliferation of oral squamous cell carcinoma

IGF-1R, a target of let-7b, mediates crosstalk between IRS-2/Akt and MAPK pathways to promote proliferation of oral squamous cell carcinoma

https://doi.org/10.18632/oncotarget.1812

Ling Gao, Xiaolong Wang, Xiaofei Wang, Linmei Zhang, Cui Qiang, Su’e Chang, Wenhao Ren, Shaoming Li, Yang Yang, Dongdong Tong, Cheng Chen, Zongfang Li, Tusheng Song, Keqian Zhi,  and Chen Huang
2562-2574
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Epigenetic silencing of EYA2 in pancreatic adenocarcinomas promotes tumor growth

Epigenetic silencing of EYA2 in pancreatic adenocarcinomas promotes tumor growth

https://doi.org/10.18632/oncotarget.1842

Audrey Vincent, Seung-Mo Hong, Chaoxin Hu, Noriyuki Omura, Angela Young, Haeryoung Kim, Jun Yu, Spencer Knight, Michael Ayars, Margaret Griffith, Isabelle Van Seuningen, Anirban Maitra,  and Michael Goggins
2575-2587
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Biomarkers of reactive resistance and early disease progression during chemotherapy plus bevacizumab treatment for colorectal carcinoma

Biomarkers of reactive resistance and early disease progression during chemotherapy plus bevacizumab treatment for colorectal carcinoma

https://doi.org/10.18632/oncotarget.1811

Hidetoshi Hayashi, Tokuzo Arao, Kazuko Matsumoto, Hideharu Kimura Kimura, Yosuke Togashi, Yoshinori Hirashima, Yosuke Horita, Satoru Iwasa, Natsuko Tsuda Okita, Yoshitaka Honma, Atsuo Takashima, Ken Kato, Tetsuya Hamaguchi, Yasuhiro Shimada, Kazuhiko Nakagawa, Kazuto Nishio,  and Yasuhide Yamada
2588-2595
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HOXC8 promotes breast tumorigenesis by transcriptionally facilitating cadherin-11 expression

HOXC8 promotes breast tumorigenesis by transcriptionally facilitating cadherin-11 expression

https://doi.org/10.18632/oncotarget.1841

Yong Li, Fengmei Chao, Bei Huang, Dahai Liu, Jaejik Kim,  and Shuang Huang
2596-2607
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YAP1 acts as oncogenic target of 11q22 amplification in multiple cancer subtypes.

YAP1 acts as oncogenic target of 11q22 amplification in multiple cancer subtypes.

https://doi.org/10.18632/oncotarget.1844

Erica Lorenzetto, Monica Brenca, Mattia Boeri, Carla Verri, Elena Piccinin, Patrizia Gasparini, Federica Facchinetti, Sabrina Rossi, Giuliana Salvatore, Maura Massimino, Gabriella Sozzi, Roberta Maestro,  and Piergiorgio Modena
2608-2621
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Targeting the MUC1-C oncoprotein inhibits self-renewal capacity of breast cancer cells

Targeting the MUC1-C oncoprotein inhibits self-renewal capacity of breast cancer cells

https://doi.org/10.18632/oncotarget.1848

Maroof Alam, Hasan Rajabi, Rehan Ahmad, Caining Jin,  and Donald Kufe
2622-2634
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Glutaminase 2 negatively regulates the PI3K/AKT signaling and shows tumor suppression activity in human hepatocellular carcinoma

Glutaminase 2 negatively regulates the PI3K/AKT signaling and shows tumor suppression activity in human hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.1862

Juan Liu, Cen Zhang, Meihua Lin, Wei Zhu, Yingjian Liang, Xuehui Hong, Yuhan Zhao, Ken H. Young, Wenwei Hu,  and Zhaohui Feng
2635-2647
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Heat shock protein 27 regulates human prostate cancer cell motility and metastatic progression

Heat shock protein 27 regulates human prostate cancer cell motility and metastatic progression

https://doi.org/10.18632/oncotarget.1917

Eric A. Voll, Irene M. Ogden, Janet M. Pavese, XiaoKe Huang, Li Xu, Borko D. Jovanovic,  and Raymond C. Bergan
2648-2663
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Isorhapontigenin (ISO) inhibited cell transformation by inducing G0/G1 phase arrest via increasing MKP-1 mRNA stability

Isorhapontigenin (ISO) inhibited cell transformation by inducing G0/G1 phase arrest via increasing MKP-1 mRNA stability

https://doi.org/10.18632/oncotarget.1872

Guangxun Gao, Liang Chen, Jingxia Li, Dongyun Zhang, Yong Fang, Haishan Huang, Xiequn Chen,  and Chuanshu Huang
2664-2677
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Sublethal concentrations of 17-AAG suppress homologous recombination DNA repair and enhance sensitivity to carboplatin and olaparib in HR proficient ovarian cancer cells

Sublethal concentrations of 17-AAG suppress homologous recombination DNA repair and enhance sensitivity to carboplatin and olaparib in HR proficient ovarian cancer cells

https://doi.org/10.18632/oncotarget.1929

Young Eun Choi, Chiara Battelli, Jacqueline Watson, Joyce Liu, Jennifer Curtis, Alexander N. Morse, Ursula A. Matulonis, Dipanjan Chowdhury,  and Panagiotis A. Konstantinopoulos
2678-2687
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Activated Alk triggers prolonged neurogenesis and Ret upregulation providing a therapeutic target in ALK-mutated neuroblastoma

Activated Alk triggers prolonged neurogenesis and Ret upregulation providing a therapeutic target in ALK-mutated neuroblastoma

https://doi.org/10.18632/oncotarget.1883

Alex Cazes, Lucille Lopez-Delisle, Konstantina Tsarovina, Cécile Pierre-Eugène, Katleen De Preter, Michel Peuchmaur, André Nicolas, Claire Provost, Caroline Louis-Brennetot, Romain Daveau, Candy Kumps, Ilaria Cascone, Gudrun Schleiermacher, Aurélie Prignon, Frank Speleman, Hermann Rohrer, Olivier Delattre,  and Isabelle Janoueix-Lerosey
2688-2702
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Hyperactivation of Alk induces neonatal lethality in knock-in AlkF1178L mice

Hyperactivation of Alk induces neonatal lethality in knock-in AlkF1178L mice

https://doi.org/10.18632/oncotarget.1882

Lucille Lopez-Delisle, Cécile Pierre-Eugène, Evelyne Bloch-Gallego, Marie-Christine Birling, Jean-Loup Duband, Estelle Durand, Thomas Bourgeois, Boris Matrot, Tania Sorg, Michel Huerre, Hamid Meziane, Michel J. Roux, Marie-France Champy, Jorge Gallego, Olivier Delattre,  and Isabelle Janoueix-Lerosey
2703-2713
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The anti-apoptotic form of tyrosine kinase Lyn that is generated by proteolysis is degraded by the N-end rule pathway

The anti-apoptotic form of tyrosine kinase Lyn that is generated by proteolysis is degraded by the N-end rule pathway

https://doi.org/10.18632/oncotarget.1931

Mohamed A. Eldeeb,  and Richard P. Fahlman
2714-2722
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Oncogenic functions of IGF1R and INSR in prostate cancer include enhanced tumor growth, cell migration and angiogenesis

Oncogenic functions of IGF1R and INSR in prostate cancer include enhanced tumor growth, cell migration and angiogenesis

https://doi.org/10.18632/oncotarget.1884

Isabel Heidegger, Johann Kern, Philipp Ofer, Helmut Klocker,  and Petra Massoner
2723-2735
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Tumor cell-produced matrix metalloproteinase 9 (MMP-9) drives malignant progression and metastasis of basal-like triple negative breast cancer

Tumor cell-produced matrix metalloproteinase 9 (MMP-9) drives malignant progression and metastasis of basal-like triple negative breast cancer

https://doi.org/10.18632/oncotarget.1932

Christine Mehner, Alexandra Hockla, Erin Miller, Sophia Ran, Derek C. Radisky,  and Evette S. Radisky
2736-2749
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The characterization of a novel monoclonal antibody against CD93 unveils a new antiangiogenic target.

The characterization of a novel monoclonal antibody against CD93 unveils a new antiangiogenic target.

https://doi.org/10.18632/oncotarget.1887

Maurizio Orlandini, Federico Galvagni, Monia Bardelli, Marina Rocchigiani, Claudia Lentucci, Francesca Anselmi, Alessio Zippo, Luca Bini,  and Salvatore Oliviero
2750-2760
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Direct endothelial junction restoration results in significant tumor vascular normalization and metastasis inhibition in mice

Direct endothelial junction restoration results in significant tumor vascular normalization and metastasis inhibition in mice

https://doi.org/10.18632/oncotarget.1942

Vijayendra Agrawal, Sony Maharjan, Kyeojin Kim, Nam-Jung Kim, Jimin Son, Keunho Lee, Hyun-Jung Choi Choi, Seung-Sik Rho, Sunjoo Ahn, Moo-Ho Won, Sang-Jun Ha, Gou Young Koh, Young-Myeong Kim, Young-Ger Suh,  and Young-Guen Kwon
2761-2777
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Indoleamine 2,3-dioxygenase mediates immune-independent human tumor cell resistance to olaparib, gamma radiation, and cisplatin

Indoleamine 2,3-dioxygenase mediates immune-independent human tumor cell resistance to olaparib, gamma radiation, and cisplatin

https://doi.org/10.18632/oncotarget.1916

Saman Maleki Vareki, Mateusz Rytelewski, Rene Figueredo, Di Chen, Peter J. Ferguson, Mark Vincent, Weiping Min, Xiufen Zheng,  and James Koropatnick
2778-2791
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microRNA-148a dysregulation discriminates poor prognosis of hepatocellular carcinoma in association with USP4 overexpression

microRNA-148a dysregulation discriminates poor prognosis of hepatocellular carcinoma in association with USP4 overexpression

https://doi.org/10.18632/oncotarget.1920

Mi Jeong Heo, Young Mi Kim, Ja Hyun Koo, Yoon Mee Yang, Jihyun An, Sook-Kyung Lee, Seung Jin Lee, Kang Mo Kim, Joong-Won Park,  and Sang Geon Kim
2792-2806
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Oncolytic reovirus preferentially induces apoptosis in KRAS mutant colorectal cancer cells, and synergizes with irinotecan

Oncolytic reovirus preferentially induces apoptosis in KRAS mutant colorectal cancer cells, and synergizes with irinotecan

https://doi.org/10.18632/oncotarget.1921

Radhashree Maitra, Raviraja Seetharam, Lydia Tesfa, Titto A. Augustine, Lidija Klampfer, Matthew C. Coffey, John M. Mariadason,  and Sanjay Goel
2807-2819
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RNA binding protein RBM14 promotes radio-resistance in glioblastoma by regulating DNA repair and cell differentiation

RNA binding protein RBM14 promotes radio-resistance in glioblastoma by regulating DNA repair and cell differentiation

https://doi.org/10.18632/oncotarget.1924

Ming Yuan, Charles G. Eberhart,  and Mihoko Kai
2820-2826
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

ROS-induced epithelial-mesenchymal transition in mammary epithelial cells is mediated by NF-κB-dependent activation of Snail

ROS-induced epithelial-mesenchymal transition in mammary epithelial cells is mediated by NF-κB-dependent activation of Snail

https://doi.org/10.18632/oncotarget.1940

Magdalena A. Cichon,  and Derek C. Radisky
2827-2838
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Multigene mutational profiling of cholangiocarcinomas identifies actionable molecular subgroups

Multigene mutational profiling of cholangiocarcinomas identifies actionable molecular subgroups

https://doi.org/10.18632/oncotarget.1943

Michele Simbolo, Matteo Fassan, Andrea Ruzzenente, Andrea Mafficini, Laura D. Wood, Vincenzo Corbo, Davide Melisi, Giuseppe Malleo, Caterina Vicentini, Giorgio Malpeli, Davide Antonello, Nicola Sperandio, Paola Capelli, Anna Tomezzoli, Calogero Iacono, Rita T. Lawlor, Claudio Bassi, Ralph H. Hruban, Alfredo Guglielmi, Giampaolo Tortora, Filippo de Braud,  and Aldo Scarpa
2839-2852
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Strategy to enhance the therapeutic effect of doxorubicin in human hepatocellular carcinoma by selenocystine, a synergistic agent that regulates the ROS-mediated signaling

Strategy to enhance the therapeutic effect of doxorubicin in human hepatocellular carcinoma by selenocystine, a synergistic agent that regulates the ROS-mediated signaling

https://doi.org/10.18632/oncotarget.1854

Cundong Fan, Wenjie Zheng, Xiaoyan Fu, Xiaoling Li, Yum-Shing Wong,  and Tianfeng Chen
2853-2863
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