Oncotarget

Vol 5, No 7

April 15, 2014

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Conjugation of human IL-12 to a DNA/histone-binding antibody increases its half-life and attenuates its ability to stimulate IFN-gamma production. Figure 1 (A) shows a ribbon diagram of NHS-IL12, an immunocytokine consisting of the NHS76 antibody fused to 2 IL-12p70 heterodimers. See Fallon et al.

Table of Contents

Editorial

IRAK1: oncotarget in MDS and AML

IRAK1: oncotarget in MDS and AML

https://doi.org/10.18632/oncotarget.1880

Levi J. Beverly,  and Daniel T. Starczynowski
1699-1700
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Reviews

Pathways and therapeutic targets in melanoma

Pathways and therapeutic targets in melanoma

https://doi.org/10.18632/oncotarget.1892

Emma Shtivelman, Michael A. Davies, Patrick Hwu, James Yang, Michal Lotem, Moshe Oren, Keith T. Flaherty,  and David E. Fisher
1701-1752
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Research Papers

Apoptotic circulating tumor cells (CTCs) in the peripheral blood of metastatic colorectal cancer patients are associated with liver metastasis but not CTCs

Apoptotic circulating tumor cells (CTCs) in the peripheral blood of metastatic colorectal cancer patients are associated with liver metastasis but not CTCs

https://doi.org/10.18632/oncotarget.1524

Joshua E. E. Allen, Bikramajit Singh Saroya, Miriam Kunkel, David . T. Dicker, Avisnata Das, Kristi L. Peters, Jamal Joudeh, Junjia Zhu,  and Wafik S. El-Deiry
1753-1760
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Spores of Clostridium engineered for clinical efficacy and safety cause regression and cure of tumors in vivo

Spores of Clostridium engineered for clinical efficacy and safety cause regression and cure of tumors in vivo

https://doi.org/10.18632/oncotarget.1761

John T. Heap, Jan Theys, Muhammad Ehsaan, Aleksandra M Kubiak, Ludwig Dubois, Kim Paesmans, Lieve Van Mellaert, Richard Knox, Sarah A. Kuehne, Phillipe Lambin,  and Nigel P. Minton
1761-1769
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Vaccinia-related kinase 1 (VRK1) confers resistance to DNA-damaging agents in human breast cancer by affecting DNA damage response

Vaccinia-related kinase 1 (VRK1) confers resistance to DNA-damaging agents in human breast cancer by affecting DNA damage response

https://doi.org/10.18632/oncotarget.1678

Marcella Salzano, Marta Vázquez-Cedeira, Marta Sanz-García, Alberto Valbuena, Sandra Blanco, Isabel F. Fernández,  and Pedro A. Lazo
1770-1778
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Hypoxia inducible factor-1 alpha as a therapeutic target in multiple myeloma

Hypoxia inducible factor-1 alpha as a therapeutic target in multiple myeloma

https://doi.org/10.18632/oncotarget.1736

Enrica Borsi, Giulia Perrone, Carolina Terragna, Marina Martello, Angela F Dico, Giancarlo Solaini, Alessandra Baracca, Gianluca Sgarbi, Gianandrea Pasquinelli, Sabrina Valente, Elena Zamagni, Paola Tacchetti, Giovanni Martinelli,  and Michele Cavo
1779-1792
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The histone demethylase JMJD1A induces cell migration and invasion by up-regulating the expression of the long noncoding RNA MALAT1

The histone demethylase JMJD1A induces cell migration and invasion by up-regulating the expression of the long noncoding RNA MALAT1

https://doi.org/10.18632/oncotarget.1785

Andrew E. Tee, Dora Ling, Charlotte Nelson, Bernard Atmadibrata, Marcel E. Dinger, Ning Xu, Tamio Mizukami, Pei Y. Liu, Bing Liu, Belamy Cheung, Eddy Pasquier, Michelle Haber, Murray D. Norris, Takayoshi Suzuki, Glenn M. Marshall,  and Tao Liu
1793-1804
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Utilization of Rad51C promoter for transcriptional targeting of cancer cells

Utilization of Rad51C promoter for transcriptional targeting of cancer cells

https://doi.org/10.18632/oncotarget.1792

Yan Cao, Yan Xu, Lei Zhang, Zhen Li, Ying Jiang, Xiao Tian, Andrei Seluanov, Vera Gorbunova,  and Zhiyong Mao
1805-1811
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Inhibition of HER2-Integrin signaling by Cucurbitacin B leads to in vitro and in vivo breast tumor growth suppression

Inhibition of HER2-Integrin signaling by Cucurbitacin B leads to in vitro and in vivo breast tumor growth suppression

https://doi.org/10.18632/oncotarget.1743

Parul Gupta,  and Sanjay K. Srivastava
1812-1828
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TERT promoter mutations in renal cell carcinomas and upper tract urothelial carcinomas

TERT promoter mutations in renal cell carcinomas and upper tract urothelial carcinomas

https://doi.org/10.18632/oncotarget.1829

Kun Wang, Tiantian Liu, Li Liu, Jikai Liu, Cheng Liu, Chang Wang, Nan Ge, Hongbo Ren, Keqiang Yan, Sanyuan Hu, Magnus Björkholm, Yidong Fan,  and Dawei Xu
1829-1836
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MET aberrations and c-MET inhibitors in patients with gastric and esophageal cancers in a phase I unit

MET aberrations and c-MET inhibitors in patients with gastric and esophageal cancers in a phase I unit

https://doi.org/10.18632/oncotarget.1828

Denis L. Fontes Jardim, Debora de Melo Gagliato, Gerald S. Falchook, Filip Janku, Ralph Zinner, Jennifer J. Wheler, Vivek Subbiah, Sarina A. Piha-Paul, Siqing Fu, Mariela Blum Murphy, Jaffer Ajani, Chad Tang, Kenneth Hess, Stanley R. Hamilton, Sinchita Roy-Chowdhuri, Razelle Kurzrock, Funda Meric-Bernstam,  and David S. Hong
1837-1845
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Advanced gynecologic malignancies treated with a combination of the VEGF inhibitor bevacizumab and the mTOR inhibitor temsirolimus

Advanced gynecologic malignancies treated with a combination of the VEGF inhibitor bevacizumab and the mTOR inhibitor temsirolimus

https://doi.org/10.18632/oncotarget.1834

Sarina A. Piha-Paul, Jennifer J. Wheler, Siqing Fu, Charles Levenback, Karen Lu, Gerald S. Falchook, Aung Naing, David S. Hong, Apostolia M. Tsimberidou,  and Razelle Kurzrock
1846-1855
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ΔNp63 isoform-mediated β-defensin family up-regulation is associated with (lymph)angiogenesis and poor prognosis in patients with squamous cell carcinoma

ΔNp63 isoform-mediated β-defensin family up-regulation is associated with (lymph)angiogenesis and poor prognosis in patients with squamous cell carcinoma

https://doi.org/10.18632/oncotarget.1819

Meggy Suarez-Carmona, Pascale Hubert, Arnaud Gonzalez, Anaelle Duray, Patrick Roncarati, Charlotte Erpicum, Jacques Boniver, Vincent Castronovo, Agnès Noel, Sven Saussez, Olivier Peulen, Philippe Delvenne,  and Michael Herfs
1856-1868
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The immunocytokine NHS-IL12 as a potential cancer therapeutic

The immunocytokine NHS-IL12 as a potential cancer therapeutic

https://doi.org/10.18632/oncotarget.1853

Jonathan Fallon, Robert Tighe, Giorgio Kradjian, Wilson Guzman, Anna Bernhardt, Berend Neuteboom, Yan Lan, Helen Sabzevari, Jeffrey Schlom,  and John W. Greiner
1869-1884
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Biglycan enhances gastric cancer invasion by activating FAK signaling pathway

Biglycan enhances gastric cancer invasion by activating FAK signaling pathway

https://doi.org/10.18632/oncotarget.1871

Lei Hu, Yan-tao Duan, Jian-fang Li, Li-ping Su, Min Yan, Zheng-gang Zhu, Bing-ya Liu,  and Qiu-meng Yang
1885-1896
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γ-tocotrienol inhibits angiogenesis-dependent growth of human hepatocellular carcinoma through abrogation of AKT/mTOR pathway in an orthotopic mouse model

γ-tocotrienol inhibits angiogenesis-dependent growth of human hepatocellular carcinoma through abrogation of AKT/mTOR pathway in an orthotopic mouse model

https://doi.org/10.18632/oncotarget.1876

Kodappully Sivaraman Siveen, Kwang Seok Ahn, Tina H. Ong, Muthu K. Shanmugam, Feng Li, Wei Ney Yap, Alan Prem Kumar, Chee Wai Fong, Vinay Tergaonkar, Kam M. Hui,  and Gautam Sethi
1897-1911
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Diffuse large B-cell lymphoma with combined TP53 mutation and MIR34A methylation: Another “double hit” lymphoma with very poor outcome?

Diffuse large B-cell lymphoma with combined TP53 mutation and MIR34A methylation: Another “double hit” lymphoma with very poor outcome?

https://doi.org/10.18632/oncotarget.1877

Fazila Asmar, Christoffer Hother, Gorjan Kulosman, Marianne Bach Treppendahl, Helene Myrtue Nielsen, Ulrik Ralfkiaer, Anja Pedersen, Michael Boe Møller, Elisabeth Ralfkiaer, Peter de Nully Brown,  and Kirsten Grønbæk
1912-1925
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PDGFRα up-regulation mediated by Sonic Hedgehog pathway activation leads to BRAF inhibitor resistance in melanoma cells with BRAF mutation

PDGFRα up-regulation mediated by Sonic Hedgehog pathway activation leads to BRAF inhibitor resistance in melanoma cells with BRAF mutation

https://doi.org/10.18632/oncotarget.1878

Francesco Sabbatino, Yangyang Wang, Xinhui Wang, Keith T. Flaherty, Ling Yu, David Pepin, Giosue’ Scognamiglio, Stefano Pepe, John M. Kirkwood, Zachary A. Cooper, Dennie T. Frederick, Jennifer A. Wargo, Soldano Ferrone,  and Cristina R. Ferrone
1926-1941
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Discovery and validation of an INflammatory PROtein-driven GAstric cancer Signature (INPROGAS) using antibody microarray-based oncoproteomics

Discovery and validation of an INflammatory PROtein-driven GAstric cancer Signature (INPROGAS) using antibody microarray-based oncoproteomics

https://doi.org/10.18632/oncotarget.1879

Manuel Puig-Costa, Antonio Codina-Cazador, Elisabet Cortés-Pastoret, Cristina Oliveras-Ferraros, Sílvia Cufí, Sílvia Flaquer, Francesca Llopis-Puigmarti, Eulalia Pujol-Amado, Bruna Corominas-Faja, Elisabet Cuyàs, Rosa Ortiz, Eugeni Lopez-Bonet, Bernardo Queralt, Raquel Guardeño, Begoña Martin-Castillo, Josep Roig, Jorge Joven,  and Javier A. Menendez
1942-1954
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A new mosaic pattern in glioma vascularization: exogenous endothelial progenitor cells integrating into the vessels containing tumor-derived endothelial cells

A new mosaic pattern in glioma vascularization: exogenous endothelial progenitor cells integrating into the vessels containing tumor-derived endothelial cells

https://doi.org/10.18632/oncotarget.1885

Xiao Chen, Jingqin Fang, Shunan Wang, Heng Liu, Xuesong Du, Jinhua Chen, Xue Li, Yizeng Yang, Bo Zhang,  and Weiguo Zhang
1955-1968
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CHIP is a novel tumor suppressor in pancreatic cancer and inhibits tumor growth through targeting EGFR

CHIP is a novel tumor suppressor in pancreatic cancer and inhibits tumor growth through targeting EGFR

https://doi.org/10.18632/oncotarget.1890

Tianxiao Wang, Jingxuan Yang, Jianwei Xu, Jian Li, Zhe Cao, Li Zhou, Lei You, Hong Shu, Zhaohui Lu, Huihua Li, Min Li, Taiping Zhang,  and Yupei Zhao
1969-1986
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Novel downstream molecular targets of SIRT1 in melanoma: a quantitative proteomics approach

Novel downstream molecular targets of SIRT1 in melanoma: a quantitative proteomics approach

https://doi.org/10.18632/oncotarget.1898

Chandra K. Singh, Jasmine George, Minakshi Nihal, Grzegorz Sabat, Raj Kumar,  and Nihal Ahmad
1987-1999
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