Oncotarget

Vol 5, No 6

March 30, 2014

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About The Cover

Structural modeling of celecoxib, DMC and other small molecule inhibitors binding to CDH11 and inhibiting the growth of MDA-MB-231 cells. Sd-133 binding capability to CDH11 was validated by SPR. Shown is a EC1 homodimer interface of CDH11 (PDB: 2A4C); one monomer is represented by the Van der Waals molecular surface (green) and the other by a ribbon. See Assefnia et al.

Table of Contents

Editorial

Invasive leader cells: metastatic oncotarget

Invasive leader cells: metastatic oncotarget

https://doi.org/10.18632/oncotarget.1870

Kevin J. Cheung,  and Andrew J. Ewald
1390-1391
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Reviews

Molecular pathways and therapeutic targets in lung cancer

Molecular pathways and therapeutic targets in lung cancer

https://doi.org/10.18632/oncotarget.1891

Emma Shtivelman, Thomas Hensing, George R. Simon, Phillip A. Dennis, Gregory A. Otterson, Raphael Bueno,  and Ravi Salgia
1392-1433
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Research Perspectives

The lncRNAs PCGEM1 and PRNCR1 are not implicated in castration resistant prostate cancer

The lncRNAs PCGEM1 and PRNCR1 are not implicated in castration resistant prostate cancer

https://doi.org/10.18632/oncotarget.1846

John R. Prensner, Anirban Sahu, Matthew K. Iyer, Rohit Malik, Benjamin Chandler, Irfan A. Asangani, Anton Poliakov, Ismael A. Vergara, Mohammed Alshalalfa, Robert B. Jenkins, Elai Davicioni, Felix Y. Feng,  and Arul M. Chinnaiyan
1434-1438
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Research Papers

Capturing the biological impact of CDKN2A and MC1R genes as an early predisposing event in melanoma and non melanoma skin cancer.

Capturing the biological impact of CDKN2A and MC1R genes as an early predisposing event in melanoma and non melanoma skin cancer.

https://doi.org/10.18632/oncotarget.1444

María José Escamez, Francisco Garcia-Garcia, Gemma Tell-Marti, Angels Fabra, Lucía Martínez-Santamaría, Celia Badenas, Paula Aguilera, Marta Pevida, Joaquín Dopazo, Marcela del Río,  and Susana Puig
1439-1451
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The genetic landscape of anaplastic astrocytoma

The genetic landscape of anaplastic astrocytoma

https://doi.org/10.18632/oncotarget.1505

Patrick J. Killela, Christopher J. Pirozzi, Zachary J. Reitman, Sian Jones, B. Ahmed Rasheed, Eric Lipp, Henry Friedman, Allan H. Friedman, Yiping He, Roger E. McLendon, Darell D. Bigner,  and Hai Yan
1452-1457
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Cadherin-11 in poor prognosis malignancies and rheumatoid arthritis: common target, common therapies.

Cadherin-11 in poor prognosis malignancies and rheumatoid arthritis: common target, common therapies.

https://doi.org/10.18632/oncotarget.1538

Shahin Assefnia, Sivanesan Dakshanamurthy, Jaime M. Guidry Auvil, Constanze Hampel, Panos Z. Anastasiadis, Bhaskar Kallakury, Aykut Uren, David W. Foley, Milton L. Brown, Lawrence Shapiro, Michael Brenner, David Haigh,  and Stephen W. Byers
1458-1474
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Celecoxib suppresses hepatoma stemness and progression by up-regulating PTEN

Celecoxib suppresses hepatoma stemness and progression by up-regulating PTEN

https://doi.org/10.18632/oncotarget.1745

Tian-Huei Chu, Hoi-Hung Chan, Hsiao-Mei Kuo, Li-Fen Liu, Tsung-Hui Hu, Cheuk-Kwan Sun, Mei-Lang Kung, Shih-Wei Lin, E-Ming Wang, Yi-Ling Ma, Kwan-Hung Cheng, Kwok-Hung Lai, Zhi-Hong Wen, Ping-I Hsu,  and Ming-Hong Tai
1475-1490
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C-kit induces epithelial–mesenchymal transition and contributes to salivary adenoid cystic cancer progression

C-kit induces epithelial–mesenchymal transition and contributes to salivary adenoid cystic cancer progression

https://doi.org/10.18632/oncotarget.1606

Ya-ling Tang, Yun-long Fan, Jian Jiang, Kai-de Li, Min Zheng, Wei Chen, Xiang-rui Ma, Ning Geng, Qian-ming Chen, Yu Chen,  and Xinhua Liang
1491-1501
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Co-targeting the MAPK and PI3K/AKT/mTOR pathways in two genetically engineered mouse models of schwann cell tumors reduces tumor grade and multiplicity

Co-targeting the MAPK and PI3K/AKT/mTOR pathways in two genetically engineered mouse models of schwann cell tumors reduces tumor grade and multiplicity

https://doi.org/10.18632/oncotarget.1609

Adrienne L. Watson, Leah K. Anderson, Andrew D. Greeley, Vincent W. Keng, Eric P. Rahrmann, Amanda L. Halfond, Natasha M. Powell, Margaret H. Collins, Tilat Rizvi, Christopher L. Moertel, Nancy Ratner,  and David A. Largaespada
1502-1514
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Mutations in IDH1, IDH2, and in the TERT promoter define clinically distinct subgroups of adult malignant gliomas

Mutations in IDH1, IDH2, and in the TERT promoter define clinically distinct subgroups of adult malignant gliomas

https://doi.org/10.18632/oncotarget.1765

Patrick J. Killela, Christopher J. Pirozzi, Patrick Healy, Zachary J. Reitman, Eric Lipp, Ahmed B. Rasheed, Rui Yang, Bill H. Diplas, Zhaohui Wang, Paula K. Greer, Huishan Zhu, Catherine Y. Wang, Austin B. Carpenter, Henry Friedman, Allan H. Friedman, Stephen T. Keir, Jie He, Yiping He, Roger E. McLendon, James E. Herndon II, Hai Yan,  and Darell D. Bigner
1515-1525
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Atg7- and Keap1-dependent autophagy protects breast cancer cell lines against mitoquinone-induced oxidative stress

Atg7- and Keap1-dependent autophagy protects breast cancer cell lines against mitoquinone-induced oxidative stress

https://doi.org/10.18632/oncotarget.1715

Yanira Gonzalez, Baikuntha Aryal, Leena Chehab,  and V Ashutosh Rao
1526-1537
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The receptor for urokinase-plasminogen activator (uPAR) controls plasticity of cancer cell movement in mesenchymal and amoeboid migration style

The receptor for urokinase-plasminogen activator (uPAR) controls plasticity of cancer cell movement in mesenchymal and amoeboid migration style

https://doi.org/10.18632/oncotarget.1754

Francesca Margheri, Cristina Luciani, Maria Letizia Taddei, Elisa Giannoni, Anna Laurenzana, Alessio Biagioni, Anastasia Chillà, Paola Chiarugi, Gabriella Fibbi,  and Mario Del Rosso
1538-1553
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RhoGDI2 promotes epithelial-mesenchymal transition via induction of Snail in gastric cancer cells

RhoGDI2 promotes epithelial-mesenchymal transition via induction of Snail in gastric cancer cells

https://doi.org/10.18632/oncotarget.1733

Hee Jun Cho, Sun-Mi Park, In-Kyu Kim, In-Koo Nam, Kyoung Eun Baek, Min-Ju Im, Jong-Min Yoo, Seung-Ho Park, Ki-Jun Ryu, Hyun-Tak Han, Hyo-Jin Kim, Soon-Chan Hong, Kwang Dong Kim, Yunbae Pak, Jae Won Kim, Chang Won Lee,  and Jiyun Yoo
1554-1564
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Thermoregulatory correlates of nausea in rats and musk shrews

Thermoregulatory correlates of nausea in rats and musk shrews

https://doi.org/10.18632/oncotarget.1732

Sukonthar Ngampramuan, Matteo Cerri, Flavia Del Vecchio, Joshua J. Corrigan, Amornrat Kamphee, Alexander S. Dragic, John A. Rudd, Andrej Romanovsky,  and Eugene Nalivaiko
1565-1575
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Roles of neutrophil gelatinase-associated lipocalin (NGAL) in human cancer

Roles of neutrophil gelatinase-associated lipocalin (NGAL) in human cancer

https://doi.org/10.18632/oncotarget.1738

Saverio Candido, Roberta Maestro, Jerry Polesel, Alessia Catania, Francesca Maira, Santo S. Signorelli, James A. McCubrey,  and Massimo Libra
1576-1594
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Prostate cancer-derived CCN3 induces M2 macrophage infiltration and contributes to angiogenesis in prostate cancer microenvironment

Prostate cancer-derived CCN3 induces M2 macrophage infiltration and contributes to angiogenesis in prostate cancer microenvironment

https://doi.org/10.18632/oncotarget.1570

Po-Chun Chen, Hsu-Chen Cheng, John Wang, Shin-Wei Wang, Huai-Ching Tai, Chiao-Wen Lin,  and Chih-Hsin Tang
1595-1608
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TBX2 represses CST6 resulting in uncontrolled legumain activity to sustain breast cancer proliferation: a novel cancer-selective target pathway with therapeutic opportunities

TBX2 represses CST6 resulting in uncontrolled legumain activity to sustain breast cancer proliferation: a novel cancer-selective target pathway with therapeutic opportunities

https://doi.org/10.18632/oncotarget.1707

Zenobia C. D'Costa, Catherine A. Higgins, Chee Wee Ong, Gareth Irwin, David Boyle, Darragh G. McArt, Karen McCloskey, Niamh E. Buckley, Nyree T. Crawford, Lalitha Thiagarajan, James T. Murray, Richard D. Kennedy, Karl A. Mulligan, Denis P. Harkin, David J.J. Waugh, Chris J. Scott, Manuel Salto-Tellez, Richard Williams,  and Paul B. Mullan
1609-1620
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Sulforaphane counteracts aggressiveness of pancreatic cancer driven by dysregulated Cx43-mediated gap junctional intercellular communication

Sulforaphane counteracts aggressiveness of pancreatic cancer driven by dysregulated Cx43-mediated gap junctional intercellular communication

https://doi.org/10.18632/oncotarget.1764

Tobias Forster, Vanessa Rausch, Yiyao Zhang, Orkhan Isayev, Katharina Heilmann, Frank Schoensiegel, Li Liu, Michelle Nessling, Karsten Richter, Sabrina Labsch, Clifford C. Nwaeburu, Juergen Mattern, Jury Gladkich, Nathalia Giese, Jens Werner, Peter Schemmer, Wolfgang Gross, Martha M. Gebhard, Clarissa Gerhauser, Michael Schaefer,  and Ingrid Herr
1621-1634
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Diagnosis of bladder cancer and prediction of survival by urinary metabolomics

Diagnosis of bladder cancer and prediction of survival by urinary metabolomics

https://doi.org/10.18632/oncotarget.1744

Xing Jin, Seok Joong Yun, Pildu Jeong, Isaac Yi Kim, Wun-Jae Kim,  and Sunghyouk Park
1635-1645
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Androgen receptor splice variants activating the full-length receptor in mediating resistance to androgen-directed therapy

Androgen receptor splice variants activating the full-length receptor in mediating resistance to androgen-directed therapy

https://doi.org/10.18632/oncotarget.1802

Bo Cao, Yanfeng Qi, Guanyi Zhang, Duo Xu, Yang Zhan, Xavier Alvarez, Zhiyong Guo, Xueqi Fu, Stephen R. Plymate, Oliver Sartor, Haitao Zhang,  and Yan Dong
1646-1656
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Linking differential radiation responses to glioma heterogeneity

Linking differential radiation responses to glioma heterogeneity

https://doi.org/10.18632/oncotarget.1823

Chao Ke, Katherine Tran, Yumay Chen, Anne T. Di Donato, Liping Yu, Yuanjie Hu, Mark E. Linskey, Ping H. Wang, Charles L. Limoli,  and Yi-Hong Zhou
1657-1665
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The NLR-related protein NWD1 is associated with prostate cancer and modulates androgen receptor signaling

The NLR-related protein NWD1 is associated with prostate cancer and modulates androgen receptor signaling

https://doi.org/10.18632/oncotarget.1850

Ricardo G. Correa, Maryla Krajewska, Carl F. Ware, Motti Gerlic,  and John C. Reed
1666-1682
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Strigolactone analogues induce apoptosis through activation of p38 and the stress response pathway in cancer cell lines and in conditionally reprogrammed primary prostate cancer cells.

Strigolactone analogues induce apoptosis through activation of p38 and the stress response pathway in cancer cell lines and in conditionally reprogrammed primary prostate cancer cells.

https://doi.org/10.18632/oncotarget.1849

Claire B. Pollock, Sara McDonough, Victor S. Wang, Hyojung Lee, Lymor Ringer, Xin Li, Cristina Prandi, Richard J. Lee, Adam S. Feldman, Hinanit Koltai, Yoram Kapulnik, Olga C. Rodriguez, Richard Schlegel, Christopher Albanese,  and Ronit I. Yarden
1683-1698
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