Oncotarget

Vol 5, No 1

January 15, 2014

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About The Cover

Molecular docking of DNMT inhibitors to AID. The best insertion model is presented by a ribbon (not shown) and surface model (cover). See Ching-Chow Chen et al.

Table of Contents

Editorial Materials

Plasticity of melanoma and EMT-TF reprogramming

Plasticity of melanoma and EMT-TF reprogramming

https://doi.org/10.18632/oncotarget.1662

Eugene Tulchinsky, J. Howard Pringle, Julie Caramel,  and Stéphane Ansieau
1-2
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DNp73: oncotarget in invasion and metastasis

DNp73: oncotarget in invasion and metastasis

https://doi.org/10.18632/oncotarget.1746

Brigitte M. Pützer
3-4
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Breaking Bad: how does a neuronal protein cause neuroendocrine cancer?

Breaking Bad: how does a neuronal protein cause neuroendocrine cancer?

https://doi.org/10.18632/oncotarget.1710

Karine Pozo, Fiemu E Nwariaku,  and James A Bibb
5-6
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A long lasting puzzle for −7/7q− syndrome

A long lasting puzzle for −7/7q− syndrome

https://doi.org/10.18632/oncotarget.1763

Hiroaki Honda,  and Toshiya Inaba
7-8
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Spherical nucleic acids for precision medicine

Spherical nucleic acids for precision medicine

https://doi.org/10.18632/oncotarget.1757

Chad A. Mirkin,  and Alexander H. Stegh
9-10
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Reviews

Targeting nucleocytoplasmic transport in cancer therapy

Targeting nucleocytoplasmic transport in cancer therapy

https://doi.org/10.18632/oncotarget.1457

Richard Hill, Bastien Cautain, Nuria de Pedro,  and Wolfgang Link
11-28
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Krüppel-like factors in cancer progression: three fingers on the steering wheel.

Krüppel-like factors in cancer progression: three fingers on the steering wheel.

https://doi.org/10.18632/oncotarget.1456

Ridha Limame, Ken Op de Beeck, Filip Lardon, Olivier De Wever,  and Patrick Pauwels
29-48
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mTOR pathway in colorectal cancer: an update

mTOR pathway in colorectal cancer: an update

https://doi.org/10.18632/oncotarget.1548

Maria Giovanna Francipane,  and Eric Lagasse
49-66
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NF2/Merlin in hereditary neurofibromatosis 2 versus cancer: biologic mechanisms and clinical associations

NF2/Merlin in hereditary neurofibromatosis 2 versus cancer: biologic mechanisms and clinical associations

https://doi.org/10.18632/oncotarget.1557

Rebecca Dunbar Schroeder, Laura S. Angelo,  and Razelle Kurzrock
67-77
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Perspectives of TGF-β inhibition in pancreatic and hepatocellular carcinomas

Perspectives of TGF-β inhibition in pancreatic and hepatocellular carcinomas

https://doi.org/10.18632/oncotarget.1569

Cindy Neuzillet, Armand de Gramont, Annemilaï Tijeras-Raballand, Louis de Mestier, Jérôme Cros, Sandrine Faivre,  and Eric Raymond
78-94
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Brief Reports

A novel immunomodulatory and molecularly targeted strategy for refractory Hodgkin’s lymphoma

A novel immunomodulatory and molecularly targeted strategy for refractory Hodgkin’s lymphoma

https://doi.org/10.18632/oncotarget.1468

Vivek Subbiah, Robert E. Brown, Mary F. McGuire, Jamie Buryanek, Filip Janku, Anas Younes,  and David Hong
95-102
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The macrophage migration inhibitory factor (MIF)-homologue D-dopachrome tautomerase is a therapeutic target in a murine melanoma model

The macrophage migration inhibitory factor (MIF)-homologue D-dopachrome tautomerase is a therapeutic target in a murine melanoma model

https://doi.org/10.18632/oncotarget.1560

Sebastian Kobold, Melanie Merk, Luisa Hofer, Philip Peters, Richard Bucala,  and Stefan Endres
103-107
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Research Papers

Tumor suppressor genes promote rhabdomyosarcoma progression in p53 heterozygous, HER-2/neu transgenic mice

Tumor suppressor genes promote rhabdomyosarcoma progression in p53 heterozygous, HER-2/neu transgenic mice

https://doi.org/10.18632/oncotarget.1171

Marianna L Ianzano, Stefania Croci, Giordano Nicoletti, Arianna Palladini, Lorena Landuzzi, Valentina Grosso, Dario Ranieri, Massimiliano Dall'Ora, Ilaria Santeramo, Milena Urbini, Carla De Giovanni, Pier Luigi Lollini,  and Patrizia Nanni
108-119
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MYCN is a novel oncogenic target in pediatric T-cell Acute Lymphoblastic Leukemia

MYCN is a novel oncogenic target in pediatric T-cell Acute Lymphoblastic Leukemia

https://doi.org/10.18632/oncotarget.1337

Annalisa Astolfi, Francesca Vendemini, Milena Urbini, Fraia Melchionda, Riccardo Masetti, Monica Franzoni, Virginia Libri, Salvatore Serravalle, Marco Togni, Giuseppina Paone, Luca Montemurro, Daniela Bressanin, Francesca Chiarini, Alberto M Martelli, Roberto Tonelli,  and Andrea Pession
120-130
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A novel androgen-regulated isoform of the TSC2 tumour suppressor gene increases cell proliferation

A novel androgen-regulated isoform of the TSC2 tumour suppressor gene increases cell proliferation

https://doi.org/10.18632/oncotarget.1405

Jennifer Munkley, Prabhakar Rajan, Nicholas P. Lafferty, Caroline Dalgliesh, Robert M. Jackson, Craig N. Robson, Hing Y. Leung,  and David J. Elliott
131-139
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Genetic subclonal complexity and miR125a-5p down-regulation identify a subset of patients with inferior outcome in low-risk CLL patients

Genetic subclonal complexity and miR125a-5p down-regulation identify a subset of patients with inferior outcome in low-risk CLL patients

https://doi.org/10.18632/oncotarget.1382

Gian Matteo Rigolin, Elena Saccenti, Lara Rizzotto, Manuela Ferracin, Sara Martinelli, Luca Formigaro, Francesca Cibien, Maurizio Cavallari, Enrico Lista, Giulia Daghia, Olga Sofritti, Maria Ciccone, Francesco Cavazzini, Laura Lupini, Cristian Bassi, Barbara Zagatti, Massimo Negrini,  and Antonio Cuneo
140-149
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Survivin promoter-regulated oncolytic adenovirus with Hsp70 gene exerts effective antitumor efficacy in gastric cancer immunotherapy

Survivin promoter-regulated oncolytic adenovirus with Hsp70 gene exerts effective antitumor efficacy in gastric cancer immunotherapy

https://doi.org/10.18632/oncotarget.1430

Weiguo Wang, Weidan Ji, Huanzhang Hu, Juming Ma, Xiaoya Li, Weiqun Mei, Yang Xu, Hui-Zhen Hu, Yan Yan, Qizhe Song, Zhigang Li,  and Changqing Su
150-160
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Anti-tumor activity of the beta-adrenergic receptor antagonist propranolol in neuroblastoma

Anti-tumor activity of the beta-adrenergic receptor antagonist propranolol in neuroblastoma

https://doi.org/10.18632/oncotarget.1083

Jennifer K Wolter, Nikolaus E Wolter, Alvaro Blanch, Teresa Partridge, Lynn Cheng, Daniel A. Morgenstern, Monika Podkowa, David R. Kaplan,  and Meredith S. Irwin
161-172
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Chloroquine synergizes with FTS to enhance cell growth inhibition and cell death

Chloroquine synergizes with FTS to enhance cell growth inhibition and cell death

https://doi.org/10.18632/oncotarget.1500

Eran Schmukler, Eya Wolfson, Roni Haklai, Galit Elad-Sfadia, Yoel Kloog,  and Ronit Pinkas-Kramarski
173-184
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The proto-oncogene KRAS is targeted by miR-200c

The proto-oncogene KRAS is targeted by miR-200c

https://doi.org/10.18632/oncotarget.1427

Florian Kopp, Ernst Wagner,  and Andreas Roidl
185-195
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Deficiency in p53 is required for doxorubicin induced transcriptional activation of NF-кB target genes in human breast cancer

Deficiency in p53 is required for doxorubicin induced transcriptional activation of NF-кB target genes in human breast cancer

https://doi.org/10.18632/oncotarget.1556

Alba Dalmases, Irene Gonzalez-Navarrete, Silvia Menendez, Oriol Arpí, Josep Maria Coromines, Sonia Servitja, Ignasi Tusquets, Cristina Chamizo, Raúl Rincón, Lluís Espinosa, Anna Bigas, Pilar Eroles, Jessica Furriol, Anna Lluch, Ana Rovira, Joan Albanell,  and Federico Rojo
196-210
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

AID downregulation is a novel function of the DNMT inhibitor 5-aza-deoxycytidine

AID downregulation is a novel function of the DNMT inhibitor 5-aza-deoxycytidine

https://doi.org/10.18632/oncotarget.1319

Chiou-Tsun Tsai, Pei-Ming Yang, Ting-Rong Chern, Shu-Hui Chuang, Jung-Hsin Lin, Lars Klemm, Markus Müschen,  and Ching-Chow Chen
211-223
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A TRAF2 binding independent region of TNFR2 is responsible for TRAF2 depletion and enhancement of cytotoxicity driven by TNFR1.

A TRAF2 binding independent region of TNFR2 is responsible for TRAF2 depletion and enhancement of cytotoxicity driven by TNFR1.

https://doi.org/10.18632/oncotarget.1492

Lucía Cabal-Hierro, Noelia Artime, Julián Iglesias, Miguel A. Prado, Lorea Ugarte-Gil, Pedro Casado, Belén Fernández-García, Bryant G. Darnay,  and Pedro S. Lazo
224-236
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Genome-wide methylation patterns provide insight into differences in breast tumor biology between American women of African and European ancestry

Genome-wide methylation patterns provide insight into differences in breast tumor biology between American women of African and European ancestry

https://doi.org/10.18632/oncotarget.1599

Christine B. Ambrosone, Allyson C. Young, Lara E. Sucheston, Dan Wang, Li Yan, Song Liu, Li Tang, Qiang Hu, Jo L. Freudenheim, Peter G. Shields, Carl D. Morrison, Kitaw Demissie,  and Michael J. Higgins
237-248
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Overexpression of 14-3-3θ promotes tumor metastasis and indicates poor prognosis in breast carcinoma

Overexpression of 14-3-3θ promotes tumor metastasis and indicates poor prognosis in breast carcinoma

https://doi.org/10.18632/oncotarget.1502

Nanlin Li, Hui Wang, Fan Jing, Chao Tong, Jixin Yang, Hongliang Wei, Jun Yi,  and Rui Ling
249-257
Abstract  |  PDF  |  HTML  |  Order a Reprint

Targeting chronic lymphocytic leukemia using CIGB-300, a clinical-stage CK2-specific cell-permeable peptide inhibitor

Targeting chronic lymphocytic leukemia using CIGB-300, a clinical-stage CK2-specific cell-permeable peptide inhibitor

https://doi.org/10.18632/oncotarget.1513

Leila R. Martins, Yasser Perera, Paulo Lúcio, Maria G. Silva, Silvio E. Perea,  and João T. Barata
258-263
Abstract  |  PDF  |  HTML  |  Order a Reprint

FOXP3 over-expression inhibits melanoma tumorigenesis via effects on proliferation and apoptosis.

FOXP3 over-expression inhibits melanoma tumorigenesis via effects on proliferation and apoptosis.

https://doi.org/10.18632/oncotarget.1600

Bee Shin Tan, Matthew R Anaka, Siddhartha Deb, Claudia Freyer, Lisa M Ebert, Anderly C Chueh, Sheren Al-Obaidi, Andreas Behren, Aparna Jayachandran, Jonathan Cebon, Weisan Chen,  and John M Mariadason
264-276
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Rac1b negatively regulates TGF-β1-induced cell motility in pancreatic ductal epithelial cells by suppressing Smad signalling

Rac1b negatively regulates TGF-β1-induced cell motility in pancreatic ductal epithelial cells by suppressing Smad signalling

https://doi.org/10.18632/oncotarget.1696

Hendrik Ungefroren, Susanne Sebens, Klaudia Giehl, Ole Helm, Stephanie Groth, Fred Faendrich, Christoph Roecken, Bence Sipos, Hendrik Lehnert,  and Frank Gieseler
277-290
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Poly (ADP-ribose) polymerase 1 transcriptional regulation: A novel crosstalk between histone modification H3K9ac and ETS1 motif hypomethylation in BRCA1-mutated ovarian cancer

Poly (ADP-ribose) polymerase 1 transcriptional regulation: A novel crosstalk between histone modification H3K9ac and ETS1 motif hypomethylation in BRCA1-mutated ovarian cancer

https://doi.org/10.18632/oncotarget.1549

Da Li, Fang-Fang Bi, Ji-Min Cao, Chen Cao, Chun-Yan Li, Bo Liu,  and Qing Yang
291-297
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint


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