Oncotarget

Vol 4, No 12

December 2013

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About The Cover

The cover for the December issue of Oncotarget was taken from Mira et al. Entitled " Lovastatin regulates Tg-neu tumor vascular phenotype.", shown is FITC-lectin-perfused Vhcl-.

Table of Contents

Editorial Materials

MicroRNAs as regulators of tumor-associated stromal cells

MicroRNAs as regulators of tumor-associated stromal cells

https://doi.org/10.18632/oncotarget.1625

Brian Ell,  and Yibin Kang
2166-2167
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MYC and MiR: vicious circle

MYC and MiR: vicious circle

https://doi.org/10.18632/oncotarget.1602

Xiaohong Zhao, Xinwei Zhang,  and Jianguo Tao
2168-2169
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Wip1 and ATM in tumor evolution: role for BRCA1.

Wip1 and ATM in tumor evolution: role for BRCA1.

https://doi.org/10.18632/oncotarget.1661

Doria Filipponi,  and Dmitry Bulavin
2170
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Reviews

Chemokines in tumor progression and metastasis

Chemokines in tumor progression and metastasis

https://doi.org/10.18632/oncotarget.1426

Purvaba J. Sarvaiya, Donna Guo, Ilya V. Ulasov, Patrik Gabikian,  and Maciej S. Lesniak
2171-2185
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Drug resistance in multiple myeloma: latest findings and new concepts on molecular mechanisms

Drug resistance in multiple myeloma: latest findings and new concepts on molecular mechanisms

https://doi.org/10.18632/oncotarget.1497

Jahangir Abdi, Guoan Chen,  and Hong Chang
2186-2207
Abstract  |  PDF  |  Erratum  |  HTML  |  Order a Reprint

Brief Reports

A loss-of-function mutation in PTCH1 suggests a role for autocrine hedgehog signaling in colorectal tumorigenesis

A loss-of-function mutation in PTCH1 suggests a role for autocrine hedgehog signaling in colorectal tumorigenesis

https://doi.org/10.18632/oncotarget.1651

Jon H. Chung,  and Fred Bunz
2208-2211
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Research Papers

Secretome from senescent melanoma engages the STAT3 pathway to favor reprogramming of naive melanoma towards a tumor-initiating cell phenotype.

Secretome from senescent melanoma engages the STAT3 pathway to favor reprogramming of naive melanoma towards a tumor-initiating cell phenotype.

https://doi.org/10.18632/oncotarget.1143

Mickaël Ohanna, Yann Cheli, Caroline Bonet, Vanessa F Bonazzi, Marylin Allegra, Sandy Giuliano, Karine Bille, Philippe Bahadoran, Damien Giacchero, Jean Philippe Lacour, Glen M Boyle, Nicholas F Hayward, Corine Bertolotto,  and Robert Ballotti
2212-2224
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Combinatorial antitumor effect of HDAC and the PI3K-Akt-mTOR pathway inhibition in a Pten defecient model of prostate cancer

Combinatorial antitumor effect of HDAC and the PI3K-Akt-mTOR pathway inhibition in a Pten defecient model of prostate cancer

https://doi.org/10.18632/oncotarget.1314

Leigh Ellis, ShengYu Ku, Swathi Ramakrishnan, Elena Lasorsa, Gizzou Azabdaftari, Alejandro Godoy,  and Roberto Pili
2225-2236
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Identification of anaplastic lymphoma kinase as a potential therapeutic target in Basal Cell Carcinoma

Identification of anaplastic lymphoma kinase as a potential therapeutic target in Basal Cell Carcinoma

https://doi.org/10.18632/oncotarget.1357

Hanna Ning, Hiroshi Mitsui, Claire Q.F. Wang, Mayte Suárez-Fariñas, Juana Gonzalez, Kejal R. Shah, Jie Chen, Israel Coats, Diane Felsen, John A. Carucci,  and James G. Krueger
2237-2248
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Induction of apoptosis by directing oncogenic Bcr-Abl into the nucleus

Induction of apoptosis by directing oncogenic Bcr-Abl into the nucleus

https://doi.org/10.18632/oncotarget.1339

Zheng-Lan Huang, Miao Gao, Qian-Yin Li, Kun Tao, Qing Xiao, Wei-Xi Cao,  and Wen-Li Feng
2249-2260
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Reduction of MLH1 and PMS2 confers temozolomide resistance and is associated with recurrence of glioblastoma

Reduction of MLH1 and PMS2 confers temozolomide resistance and is associated with recurrence of glioblastoma

https://doi.org/10.18632/oncotarget.1302

Yoshinari Shinsato, Tatsuhiko Furukawa, Shunji Yunoue, Hajime Yonezawa, Kentarou Minami, Yukihiko Nishizawa, Ryuji Ikeda, Kohichi Kawahara, Masatatsu Yamamoto, Hirofumi Hirano, Hiroshi Tokimura,  and Kazunori Arita
2261-2270
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A tumor-promoting mechanism mediated by retrotransposon-encoded reverse transcriptase is active in human transformed cell lines

A tumor-promoting mechanism mediated by retrotransposon-encoded reverse transcriptase is active in human transformed cell lines

https://doi.org/10.18632/oncotarget.1403

Ilaria Sciamanna, Alberto Gualtieri, Cristina Cossetti, Emanuele Felice Osimo, Manuela Ferracin, Gianfranco Macchia, Eleonora Arico, Gianni Prosseda, Patrizia Vitullo, Tom Misteli,  and Corrado Spadafora
2271-2287
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A lovastatin-elicited genetic program inhibits M2 macrophage polarization and enhances T cell infiltration into spontaneous mouse mammary tumors

A lovastatin-elicited genetic program inhibits M2 macrophage polarization and enhances T cell infiltration into spontaneous mouse mammary tumors

https://doi.org/10.18632/oncotarget.1376

Emilia Mira, Lorena Carmona-Rodríguez, Manuel Tardáguila, Iñigo Azcoitia, Alicia González-Martín, Luis Almonacid, Josefina Casas, Gemma Fabriás,  and Santos Mañes
2288-2301
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Impaired angiogenesis and tumor development by inhibition of the mitotic kinesin Eg5

Impaired angiogenesis and tumor development by inhibition of the mitotic kinesin Eg5

https://doi.org/10.18632/oncotarget.1490

Prisca Exertier, Sophie Javerzat, Baigang Wang, Mélanie Franco, John M. Herbert, Natalia Platonova, Marie Winandy, Nadège Pujol, Olivier Nivelles, Sandra Ormenese, Virginie Godard, Jürgen Becker, Roy Bicknell, Raphael Pineau, Jörg Wilting, Andreas Bikfalvi,  and Martin Hagedorn
2302-2316
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HOXA11 hypermethylation is associated with progression of non-small cell lung cancer

HOXA11 hypermethylation is associated with progression of non-small cell lung cancer

https://doi.org/10.18632/oncotarget.1464

Jung-Ah Hwang, Bo Bin Lee, Yujin Kim, Seong-Eun Park, Kyun Heo, Seung-Hyun Hong, Young-Ho Kim, Joungho Han, Duk-Hwan Kim, Young Mog Shim,  and Yeon-Su Lee
2317-2325
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Enrichment of human osteosarcoma stem cells based on hTERT transcriptional activity

Enrichment of human osteosarcoma stem cells based on hTERT transcriptional activity

https://doi.org/10.18632/oncotarget.1554

Ling Yu, Shiqing Liu, Chun Zhang, Bo Zhang, Bruno M. Simoes, Rachel Eyre, Yi Liang, Huichao Yan, Zheng Wu, Weichun Guo,  and Robert B. Clarke
2326-2338
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SCFβ-TRCP targets MTSS1 for ubiquitination-mediated destruction to regulate cancer cell proliferation and migration

SCFβ-TRCP targets MTSS1 for ubiquitination-mediated destruction to regulate cancer cell proliferation and migration

https://doi.org/10.18632/oncotarget.1446

Jiateng Zhong, Shavali Shaik, Lixin Wan, Adriana E. Tron, Zhiwei Wang, Liankun Sun, Hiroyuki Inuzuka,  and Wenyi Wei
2339-2353
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Inhibition of SIRT2 in merlin/NF2-mutant Schwann cells triggers necrosis

Inhibition of SIRT2 in merlin/NF2-mutant Schwann cells triggers necrosis

https://doi.org/10.18632/oncotarget.1422

Alejandra M. Petrilli, Marga Bott,  and Cristina Fernández-Valle
2354-2365
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Ovarian cancer stem-like cells with induced translineage-differentiation capacity and are suppressed by alkaline phosphatase inhibitor

Ovarian cancer stem-like cells with induced translineage-differentiation capacity and are suppressed by alkaline phosphatase inhibitor

https://doi.org/10.18632/oncotarget.1424

Kuei-Chun Liu, Yi-Te Yo, Rui-Lan Huang, Yu-Chi Wang, Yu-Ping Liao, Tien-Shuo Huang, Tai-Kuang Chao, Chi-Kang Lin, Shao-Ju Weng, Kuo-Hsing Ma, Cheng-Chang Chang, Mu-Hsien Yu,  and Hung-Cheng Lai
2366-2382
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

EI24 regulates epithelial-to-mesenchymal transition and tumor progression by suppressing TRAF2-mediated NF-κB activity

EI24 regulates epithelial-to-mesenchymal transition and tumor progression by suppressing TRAF2-mediated NF-κB activity

https://doi.org/10.18632/oncotarget.1434

Jung-Min Choi, Sushil Devkota, Young Hoon Sung,  and Han-Woong Lee
2383-2396
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1 alpha, 25-dihydroxylvitamin D3 promotes Bacillus Calmette-Guérin immunotherapy of bladder cancer

1 alpha, 25-dihydroxylvitamin D3 promotes Bacillus Calmette-Guérin immunotherapy of bladder cancer

https://doi.org/10.18632/oncotarget.1494

Jong-Wei Hsu, Peng-Nien Yin, Ronald Wood, James Messing, Edward Messing,  and Yi-Fen Lee
2397-2406
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In situ mutation detection and visualization of intratumor heterogeneity for cancer research and diagnostics

In situ mutation detection and visualization of intratumor heterogeneity for cancer research and diagnostics

https://doi.org/10.18632/oncotarget.1527

Ida Grundberg, Sara Kiflemariam, Marco Mignardi, Juliana Imgenberg-Kreuz, Karolina Edlund, Patrick Micke, Magnus Sundström, Tobias Sjöblom, Johan Botling,  and Mats Nilsson
2407-2418
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Inhibition of BET bromodomain proteins as a therapeutic approach in prostate cancer.

Inhibition of BET bromodomain proteins as a therapeutic approach in prostate cancer.

https://doi.org/10.18632/oncotarget.1572

Anastasia Wyce, Yan Degenhardt, Yuchen Bai, BaoChau Le, Susan Korenchuk, Ming-Chih Crouthamel, Charles McHugh, Robert Vessella, Caretha Creasy, Peter Tummino,  and Olena Barbash
2419-2429
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Gefitinib resistance resulted from STAT3-mediated Akt activation in lung cancer cells

Gefitinib resistance resulted from STAT3-mediated Akt activation in lung cancer cells

https://doi.org/10.18632/oncotarget.1431

Kai Wu, Qingshan Chang, Yongju Lu, Ping Qiu, Bailing Chen, Chitra Thakur, Jiaying Sun, Lingzhi Li, Anjaneyulu Kowluru,  and Fei Chen
2430-2438
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Evaluation of Zinc (II) chelators for inhibiting p53-mediated apoptosis

Evaluation of Zinc (II) chelators for inhibiting p53-mediated apoptosis

https://doi.org/10.18632/oncotarget.1535

Akinori Morita, Shinya Ariyasu, Soichiro Ohya, Ippei Takahashi, Bing Wang, Kaoru Tanaka, Takatoshi Uchida, Haruna Okazaki, Kengo Hanaya, Atsushi Enomoto, Mitsuru Nenoi, Masahiko Ikekita, Shin Aoki,  and Yoshio Hosoi
2439-2450
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Dietary protein restriction inhibits tumor growth in human xenograft models

Dietary protein restriction inhibits tumor growth in human xenograft models

https://doi.org/10.18632/oncotarget.1586

Luigi Fontana, Remi M. Adelaiye, Antonella L. Rastelli, Kiersten Marie Miles, Eric Ciamporcero, Valter D. Longo, Holly Nguyen, Robert Vessella,  and Roberto Pili
2451-2461
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High aldehyde dehydrogenase activity identifies cancer stem cells in human cervical cancer

High aldehyde dehydrogenase activity identifies cancer stem cells in human cervical cancer

https://doi.org/10.18632/oncotarget.1578

Shuyan Liu,  and Pengsheng Zheng
2462-2475
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FAM83D promotes cell proliferation and motility by downregulating tumor suppressor gene FBXW7

FAM83D promotes cell proliferation and motility by downregulating tumor suppressor gene FBXW7

https://doi.org/10.18632/oncotarget.1581

Zeran Wang, Yueyong Liu, Pengju Zhang, Weiguo Zhang, Weijing Wang, Kenneth Curr, Guangwei Wei,  and Jian-Hua Mao
2476-2486
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Hypoxia shifts activity of neuropeptide Y in Ewing sarcoma from growth-inhibitory to growth-promoting effects

Hypoxia shifts activity of neuropeptide Y in Ewing sarcoma from growth-inhibitory to growth-promoting effects

https://doi.org/10.18632/oncotarget.1604

Jason U. Tilan, Congyi Lu, Susana Galli, Ewa Izycka-Swieszewska, Joshua P. Earnest, Asim Shabbir, Lindsay M. Everhart, Shuo Wang, Samantha Martin, Meredith Horton, Akanksha Mahajan, David Christian, Alison O'Neill, Hongkun Wang, Tingting Zhuang, Magdalena Czarnecka, Michael D. Johnson, Jeffrey A. Toretsky,  and Joanna B. Kitlinska
2487-2501
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Phosphoglycerate dehydrogenase is dispensable for breast tumor maintenance and growth

Phosphoglycerate dehydrogenase is dispensable for breast tumor maintenance and growth

https://doi.org/10.18632/oncotarget.1540

Jinyun Chen, Franklin Chung, Guizhi Yang, Minying Pu, Hui Gao, Wei Jiang, Hong Yin, Vladimir Capka, Shailaja Kasibhatla, Bryan Laffitte, Savina Jaeger, Raymond Pagliarini, Yaoyu Chen,  and Wenlai Zhou
2502-2511
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Loss of E-cadherin activates EGFR-MEK/ERK signaling, which promotes invasion via the ZEB1/MMP2 axis in non-small cell lung cancer

Loss of E-cadherin activates EGFR-MEK/ERK signaling, which promotes invasion via the ZEB1/MMP2 axis in non-small cell lung cancer

https://doi.org/10.18632/oncotarget.1463

Gab-Yong Bae, So-Jung Choi, Ji-Seon Lee, Jisuk Jo, Jinseon Lee, Jhingook Kim,  and Hyuk-Jin Cha
2512-2522
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Extracellular p53 fragment re-enters K-Ras mutated cells through the caveolin-1 dependent early endosomal system

Extracellular p53 fragment re-enters K-Ras mutated cells through the caveolin-1 dependent early endosomal system

https://doi.org/10.18632/oncotarget.1550

Sun-Hye Lee, Tae-Gyun Woo, Su-Jin Lee, Nam-Chul Ha,  and Bum-Joon Park
2523-2531
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The polycomb group protein EZH2 is a novel therapeutic target in tongue cancer

The polycomb group protein EZH2 is a novel therapeutic target in tongue cancer

https://doi.org/10.18632/oncotarget.1503

Zhongwu li, Yanling Wang, Jing Qiu, Qiang Li, Chunping Yuan, Wei Zhang, Dongmiao Wang, Jinhai Ye, Hongbin Jiang, Jianrong Yang,  and Jie Cheng
2532-2549
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Resistance to Dasatinib in primary chronic lymphocytic leukemia lymphocytes involves AMPK-mediated energetic re-programming

Resistance to Dasatinib in primary chronic lymphocytic leukemia lymphocytes involves AMPK-mediated energetic re-programming

https://doi.org/10.18632/oncotarget.1508

Veronica Martinez-Marignac, Nader Toban, Miguel Bazile,  and Raquel Aloyz
2550-2566
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Research Perspectives

Endothelial hypoxic metabolism in carcinogenesis and dissemination : HIF-A isoforms are a NO metastatic phenomenon

Endothelial hypoxic metabolism in carcinogenesis and dissemination : HIF-A isoforms are a NO metastatic phenomenon

https://doi.org/10.18632/oncotarget.1461

Cristina Branco-Price, Colin E. Evans,  and Randall S. Johnson
2567-2576
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Anti-oxidative stress response genes: bioinformatic analysis of their expression and relevance in multiple cancers

Anti-oxidative stress response genes: bioinformatic analysis of their expression and relevance in multiple cancers

https://doi.org/10.18632/oncotarget.1658

Barak Rotblat, Thomas G. P. Grunewald, Gabriel Leprivier, Gerry Melino,  and Richard A. Knight
2577-2590
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