Oncotarget

Vol 4, No 11

November 2013

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About The Cover

MVP expression in GBM and establishment of stable MVP-overexpressing H7 sublines. Immunofluorescence staining of endogenous MVP (green) in the cytoplasm of MR-1 GBM cells; nuclei (blue) by DAPI; microfilaments (red) by TRITC-phalloidin (bar = 10 µm). See Lötsch et al.

Table of Contents

Editorial Materials

CDK6 and p16INK4a in lymphoid malignancies

CDK6 and p16INK4a in lymphoid malignancies

https://doi.org/10.18632/oncotarget.1541

Karoline Kollmann,  and Veronika Sexl
1858-1859
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Targeting IL-11 signaling in colon cancer

Targeting IL-11 signaling in colon cancer

https://doi.org/10.18632/oncotarget.1410

Matthias Ernst,  and Tracy L. Putoczki
1860-1861
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Hexokinase 2 as oncotarget.

Hexokinase 2 as oncotarget.

https://doi.org/10.18632/oncotarget.1563

Krushna C. Patra,  and Nissim Hay
1862-1863
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Editorial Broadcast

p16 in HPV-associated cancers

p16 in HPV-associated cancers

https://doi.org/10.18632/oncotarget.1523

Karl Munger, Tyshia K. Gwin,  and Margaret E. McLaughlin-Drubin
1864-1865
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News and Commentaries

Mouse models and anti-HER2 therapies

Mouse models and anti-HER2 therapies

https://doi.org/10.18632/oncotarget.1481

Ariella B. Hanker, Rebecca S. Cook,  and Carlos L. Arteaga
1866-1867
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Reviews

Computational methods for detecting copy number variations in cancer genome using next generation sequencing: principles and challenges

Computational methods for detecting copy number variations in cancer genome using next generation sequencing: principles and challenges

https://doi.org/10.18632/oncotarget.1537

Biao Liu, Carl D. Morrison, Candace S. Johnson, Donald L. Trump, Maochun Qin, Jeffrey C. Conroy, Jianmin Wang,  and Song Liu
1868-1881
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Research Papers

Increased expression and copy number amplification of LINE-1 and SINE B1 retrotransposable elements in murine mammary carcinoma progression

Increased expression and copy number amplification of LINE-1 and SINE B1 retrotransposable elements in murine mammary carcinoma progression

https://doi.org/10.18632/oncotarget.1188

Alberto Gualtieri, Federica Andreola, Ilaria Sciamanna, Paola Sinibaldi Vallebona, Annalucia Serafino,  and Corrado Spadafora
1882-1893
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TAp63 regulates oncogenic miR-155 to mediate migration and tumour growth

TAp63 regulates oncogenic miR-155 to mediate migration and tumour growth

https://doi.org/10.18632/oncotarget.1228

Sam Mattiske, Kristen Ho, Jacqueline E. Noll, Paul M. Neilsen, David F. Callen,  and Rachel J. Suetani
1894-1903
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Major vault protein supports glioblastoma survival and migration by upregulating the EGFR/PI3K signalling axis

Major vault protein supports glioblastoma survival and migration by upregulating the EGFR/PI3K signalling axis

https://doi.org/10.18632/oncotarget.1264

Daniela Loetsch, Elisabeth Steiner, Klaus Holzmann, Sabine Spiegl-Kreinecker, Christine Pirker, Juraj Hlavaty, Helga Petznek, Balazs Hegedus, Tamas Garay, Thomas Mohr, Wolfgang Sommergruber, Walter Berger,  and Michael Grusch
1904-1918
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Identification of novel tumor suppressor proteases by degradome profiling of colorectal carcinomas

Identification of novel tumor suppressor proteases by degradome profiling of colorectal carcinomas

https://doi.org/10.18632/oncotarget.1303

Julia M. Fraile, Gonzalo R. Ordoñez, Pedro M. Quiros, Aurora Astudillo, Jose A. Galvan, Dolors Colomer, Carlos Lopez-Otin, Jose M.P. Freije,  and Xose S. Puente
1919-1932
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HoxA9 regulated Bcl-2 expression mediates survival of myeloid progenitors and the severity of HoxA9-dependent leukemia

HoxA9 regulated Bcl-2 expression mediates survival of myeloid progenitors and the severity of HoxA9-dependent leukemia

https://doi.org/10.18632/oncotarget.1306

Gabriela Brumatti, Marika Salmanidis, Chung H Kok, Rebecca A Bilardi, Jarrod J Sandow, Natasha Silke, Kylie Manson, Jolanda Visser, Anissa M Jabbour, Stefan P Glaser, Toru Okamoto, Philippe Bouillet, Richard J D'Andrea,  and Paul G Ekert
1933-1947
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Selective targeting of human colon cancer stem-like cells by the mTOR inhibitor Torin-1

Selective targeting of human colon cancer stem-like cells by the mTOR inhibitor Torin-1

https://doi.org/10.18632/oncotarget.1310

Maria Giovanna Francipane,  and Eric Lagasse
1948-1962
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Mode of cell death induced by the HSP90 inhibitor 17-AAG (tanespimycin) is dependent on the expression of pro-apoptotic BAX

Mode of cell death induced by the HSP90 inhibitor 17-AAG (tanespimycin) is dependent on the expression of pro-apoptotic BAX

https://doi.org/10.18632/oncotarget.1419

Marissa V Powers, Melanie Valenti, Susana Mirander, Alison Maloney, Suzanne A Eccles, George Thomas, Paul A Clarke,  and Paul Workman
1963-1975
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

p53 regulates the transcription of the anti-inflammatory molecule developmental endothelial locus-1 (Del-1)

p53 regulates the transcription of the anti-inflammatory molecule developmental endothelial locus-1 (Del-1)

https://doi.org/10.18632/oncotarget.1318

Hyesoon Kim, Seung-Hwan Lee, Mi-Ni Lee, Goo Taeg Oh, Kyung-Chul Choi,  and Eun Young Choi
1976-1985
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Mitochondrial oxidative stress is the achille’s heel of melanoma cells resistant to Braf-mutant inhibitor

Mitochondrial oxidative stress is the achille’s heel of melanoma cells resistant to Braf-mutant inhibitor

https://doi.org/10.18632/oncotarget.1420

Paola Corazao-Rozas, Pierre Guerreschi, Manel Jendoubi, Fanny André, Aurélie Jonneaux, Camille Scalbert, Guillaume Garçon, Myriam Mallet-Martino, Stéphane Balayssac, Stephane Rocchi, Ariel Savina, Pierre Formstecher, Laurent Mortier, Jerome Kluza,  and Philippe Marchetti
1986-1998
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Chemoresistance to gemcitabine in hepatoma cells induces epithelial-mesenchymal transition and involves activation of PDGF-D pathway

Chemoresistance to gemcitabine in hepatoma cells induces epithelial-mesenchymal transition and involves activation of PDGF-D pathway

https://doi.org/10.18632/oncotarget.1471

Qiong Wu, Rui Wang, Qingling Yang, Xin Hou, Sulian Chen, Yueyue Hou, Changjie Chen, Yan Yang, Lucio Miele, Fazlul Sarkar, Yuqing Chen,  and Zhiwei Wang
1999-2009
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NFkB disrupts tissue polarity in 3D by preventing integration of microenvironmental signals

NFkB disrupts tissue polarity in 3D by preventing integration of microenvironmental signals

https://doi.org/10.18632/oncotarget.1451

Sabine Becker-Weimann, Gaofeng Xiong, Saori Furuta, Ju Han, Irene Kuhn, Uri-David Akavia, Dana Pe'er, Mina J. Bissell,  and Ren Xu
2010-2020
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FOXD3 is a novel tumor suppressor that affects growth, invasion, metastasis and angiogenesis of neuroblastoma

FOXD3 is a novel tumor suppressor that affects growth, invasion, metastasis and angiogenesis of neuroblastoma

https://doi.org/10.18632/oncotarget.1579

Dan Li, Hong Mei, Meng Qi, Dehua Yang, Xiang Zhao, Xuan Xiang, Jiarui Pu, Kai Huang, Liduan Zheng,  and Qiangsong Tong
2021-2044
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

14-3-3σ attenuates RhoGDI2-induced cisplatin resistance through activation of Erk and p38 in gastric cancer cells

14-3-3σ attenuates RhoGDI2-induced cisplatin resistance through activation of Erk and p38 in gastric cancer cells

https://doi.org/10.18632/oncotarget.1334

In-Kyu Kim, Sun-Mi Park, Hee Jun Cho, Kyoung Eun Baek, In-Koo Nam, Seung-Ho Park, Ki-Jun Ryu, Jinhyun Ryu, Jungil Choi, Soon-Chan Hong, Jae Won Kim, Chang Won Lee, Sang Soo Kang,  and Jiyun Yoo
2045-2056
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Induction and transport of Wnt 5a during macrophage-induced malignant invasion is mediated by two types of extracellular vesicles

Induction and transport of Wnt 5a during macrophage-induced malignant invasion is mediated by two types of extracellular vesicles

https://doi.org/10.18632/oncotarget.1336

Kerstin Menck, Florian Klemm, Julia Christina Gross, Tobias Pukrop, Dirk Wenzel,  and Claudia Binder
2057-2066
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Alterations of immune response of non-small cell lung cancer with Azacytidine

Alterations of immune response of non-small cell lung cancer with Azacytidine

https://doi.org/10.18632/oncotarget.1542

John Wrangle, Wei Wang, Alexander Koch, Hariharan Easwaran, Helai P. Mohammad, Xiaoyu Pan, Frank Vendetti, Wim VanCriekinge, Tim DeMeyer, Zhengzong Du, Princy Parsana, Kristen Rodgers, Ray-Whay Yen, Cynthia A. Zahnow, Janis M. Taube, Julie R. Brahmer, Scott S. Tykodi, Keith Easton, Richard D. Carvajal, Peter A. Jones, Peter W. Laird, Daniel J. Weisenberger, Salina Tsai, Rosalyn A. Juergens, Suzanne L. Topalian, Charles M. Rudin, Malcolm V. Brock, Drew Pardoll,  and Stephen B. Baylin
2067-2079
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

BET bromodomain protein inhibition is a therapeutic option for medulloblastoma

BET bromodomain protein inhibition is a therapeutic option for medulloblastoma

https://doi.org/10.18632/oncotarget.1534

Anton George Henssen, Theresa Thor, Andrea Odersky, Lukas Heukamp, Nicolai El-Hindy, Anneleen Beckers, Frank Slpeleman, Kristina Althoff, Simon Schäfers, Alexander Schramm, Ulrich Sure, Gudrun Fleischhack, Angelika Eggert,  and Johannes Hubertus Schulte
2080-2095
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

ICRAC controls the rapid androgen response in human primary prostate epithelial cells and is altered in prostate cancer

ICRAC controls the rapid androgen response in human primary prostate epithelial cells and is altered in prostate cancer

https://doi.org/10.18632/oncotarget.1483

Christian Holzmann, Tatiana Kilch, Sven Kappel, Andrea Armbrüster, Volker Jung, Michael Stöckle, Ivan Bogeski, Eva C Schwarz,  and Christine Peinelt
2096-2107
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Bone marrow adipocytes promote tumor growth in bone via FABP4-dependent mechanisms

Bone marrow adipocytes promote tumor growth in bone via FABP4-dependent mechanisms

https://doi.org/10.18632/oncotarget.1482

Mackenzie Herroon, Erandi Rajagurubandara, Aimalie L Hardaway, Katelyn Powell, Audrey Turchick, Daniel Feldmann,  and Izabela Podgorski
2108-2123
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6p22.3 amplification as a biomarker and potential therapeutic target of advanced stage bladder cancer

6p22.3 amplification as a biomarker and potential therapeutic target of advanced stage bladder cancer

https://doi.org/10.18632/oncotarget.1485

He Shen, Carl D. Morrison, Jianmin Zhang, Willie Underwood III, Nuo Yang, Costa Frangou, Kevin Eng, Karen Head, Roni J. Bollag, Sravan K. Kavuri, Amyn M. Rojiani, Yingwei Li, Li Yan, Annette Hill, Anna Woloszynska-Read, Jianmin Wang, Song Liu, Donald L. Trump,  and Candace S. Johnson
2124-2134
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Aberrant chimeric RNA GOLM1-MAK10 encoding a secreted fusion protein as a molecular signature for human esophageal squamous cell carcinoma

Aberrant chimeric RNA GOLM1-MAK10 encoding a secreted fusion protein as a molecular signature for human esophageal squamous cell carcinoma

https://doi.org/10.18632/oncotarget.1465

Hao Zhang, Wan Lin, Kalpana Kannan, Liming Luo, Jing Li, Pei-Wen Chao, Yan Wang, Yu-Ping Chen, Jiang Gu,  and Laising Yen
2135-2143
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

KMT2D maintains neoplastic cell proliferation and global histone H3 lysine 4 monomethylation

KMT2D maintains neoplastic cell proliferation and global histone H3 lysine 4 monomethylation

https://doi.org/10.18632/oncotarget.1555

Changcun Guo, Lee H. Chen, Yafen Huang, Chun-Chi Chang, Ping Wang, Christopher J. Pirozzi, Xiaoxia Qin, Xuhui Bao, Paula K. Greer, Roger E. McLendon, Hai Yan, Stephen T. Keir, Darell D. Bigner,  and Yiping He
2144-2153
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Aberrantly hypermethylated Homeobox A2 derepresses metalloproteinase-9 through TBP and promotes invasion in Nasopharyngeal carcinoma

Aberrantly hypermethylated Homeobox A2 derepresses metalloproteinase-9 through TBP and promotes invasion in Nasopharyngeal carcinoma

https://doi.org/10.18632/oncotarget.1367

Hsin-Pai Li, Chen-Ching Peng, I-Che Chung, Mei-Yuan Huang, Shao-Tung Huang, Chia-Chun Chen, Kai-Ping Chang, Cheng-Lung Hsu,  and Yu-Sun Chang
2154-2165
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