Oncotarget

Vol 4, No 10

October 2013

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About The Cover

The cover of the October issue of Oncotarget features the first figure from Couty et al. showing chimera and native PKA-S6K1.

Table of Contents

Editorial Materials

In vivo selection of tumor-specific antibodies

In vivo selection of tumor-specific antibodies

https://doi.org/10.18632/oncotarget.1407

David Sánchez-Martín, Laura Sanz, Erkki Ruoslahti,  and Luis Alvarez-Vallina
1547
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Estrogen response in luminal breast cancer

Estrogen response in luminal breast cancer

https://doi.org/10.18632/oncotarget.1354

Leticia B A Rangel,  and Tim Hui-Ming Huang
1548-1549
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IκBα beyond the NF-kB dogma

IκBα beyond the NF-kB dogma

https://doi.org/10.18632/oncotarget.1325

María Carmen Mulero, Anna Bigas,  and Lluís Espinosa
1550-1551
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Cytokine-induced ‘bystander’ senescence in DDR and immuno-surveillance

Cytokine-induced ‘bystander’ senescence in DDR and immuno-surveillance

https://doi.org/10.18632/oncotarget.1487

Zdenek Hodny, Sona Hubackova,  and Jiri Bartek
1552-1553
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Ribosomes: the future of targeted therapies?

Ribosomes: the future of targeted therapies?

https://doi.org/10.18632/oncotarget.1511

Virginie Marcel, Frédéric Catez,  and Jean-Jacques Diaz
1554-1555
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Reviews

Lysine-specific modifications of p53: a matter of life and death?

Lysine-specific modifications of p53: a matter of life and death?

https://doi.org/10.18632/oncotarget.1436

Diana Marouco, Alexander V Garabadgiu, Gerry Melino,  and Nick A Barlev
1556-1571
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Research Papers

The predictive value of 53BP1 and BRCA1 mRNA expression in advanced non-small-cell lung cancer patients treated with first-line platinum-based chemotherapy

The predictive value of 53BP1 and BRCA1 mRNA expression in advanced non-small-cell lung cancer patients treated with first-line platinum-based chemotherapy

https://doi.org/10.18632/oncotarget.1157

Laura Bonanno, Carlota Costa, Margarita Majem, Jose Javier Sanchez, Ana Gimenez-Capitan, Ignacio Rodriguez, Alain Vergenegre, Bartomeu Massuti, Adolfo Favaretto, Massimo Rugge, Cinta Pallares, Miquel Taron,  and Rafael Rosell
1572-1581
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High imatinib dose overcomes insufficient response associated with ABCG2 haplotype in chronic myelogenous leukemia patients

High imatinib dose overcomes insufficient response associated with ABCG2 haplotype in chronic myelogenous leukemia patients

https://doi.org/10.18632/oncotarget.1050

Marc Delord, Philippe Rousselot, Jean-Michel Cayuela, François Sigaux, Joëlle Guilhot, Claude Preudhomme, François Guilhot, Pascale Loiseau, Emmanuel Raffoux, Daniela Geromin, Emmanuelle Genin, Fabien Calvo,  and Heriberto Bruzzoni-Giovanelli
1582-1591
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Neratinib overcomes trastuzumab resistance in HER2 amplified breast cancer

Neratinib overcomes trastuzumab resistance in HER2 amplified breast cancer

https://doi.org/10.18632/oncotarget.1148

Alexandra Canonici, Merel Gijsen, Maeve Mullooly, Ruth Bennett, Noujoude Bouguern, Kasper Pedersen, Neil A O’Brien, Ioannis Roxanis, Ji-Liang Li, Esther Bridge, Richard Finn, Dennis Slamon, Patricia McGowan, Michael J. Duffy, Norma O’Donovan, John Crown,  and Anthony Kong
1592-1605
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Small-molecule targeting of translation initiation for cancer therapy

Small-molecule targeting of translation initiation for cancer therapy

https://doi.org/10.18632/oncotarget.1186

Bertal H. Aktas, Yuan Qiao, Esra Ozdelen, Roland Schubert, Sema Sevinc, Fred Harbinski, Luciano Grubissich, Samuel Singer,  and Jose A. Halperin
1606-1617
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Notch3 inhibition enhances sorafenib cytotoxic efficacy by promoting GSK3β phosphorylation and p21 down-regulation in hepatocellular carcinoma

Notch3 inhibition enhances sorafenib cytotoxic efficacy by promoting GSK3β phosphorylation and p21 down-regulation in hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.1221

Catia Giovannini, Michele Baglioni, Marco Baron Toaldo, Cristiano Ventrucci, Stefania D'Adamo, Mario Cipone, Pasquale Chieco, Laura Gramantieri,  and Luigi Bolondi
1618-1631
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The FAK scaffold inhibitor C4 disrupts FAK-VEGFR-3 signaling and inhibits pancreatic cancer growth

The FAK scaffold inhibitor C4 disrupts FAK-VEGFR-3 signaling and inhibits pancreatic cancer growth

https://doi.org/10.18632/oncotarget.1365

Elena Kurenova, Jianqun Liao, Di-Hua He, Darrell Hunt, Michael Yemma, Wiam Bshara, Mukund Seshadri,  and William G Cance
1632-1646
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The discovery of potent ribosomal S6 kinase inhibitors by high-throughput screening and structure-guided drug design

The discovery of potent ribosomal S6 kinase inhibitors by high-throughput screening and structure-guided drug design

https://doi.org/10.18632/oncotarget.1255

Sylvain Couty, Isaac M. Westwood, Andrew Kalusa, Celine Cano, Jon Travers, Kathy Boxall, Chiau Ling Chow, Sam Burns, Jessica Schmitt, Lisa Pickard, Caterina Barillari, P. Craig McAndrew, Paul A. Clarke, Spiros Linardopoulos, Roger J. Griffin, G. Wynne Aherne, Florence I. Raynaud, Paul Workman, Keith Jones,  and Rob L.M. van Montfort
1647-1661
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HER4 expression status correlates with improved outcome in both neoadjuvant and adjuvant Trastuzumab treated invasive breast carcinoma

HER4 expression status correlates with improved outcome in both neoadjuvant and adjuvant Trastuzumab treated invasive breast carcinoma

https://doi.org/10.18632/oncotarget.1232

Bryce P Portier, Eugen C. Minca, Zhen Wang, Christopher Lanigan, Aaron M. Gruver, Erinn Downs-Kelly, G. Thomas Budd,  and Raymond R. Tubbs
1662-1672
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Regulation of histone H2A.Z expression is mediated by sirtuin 1 in prostate cancer

Regulation of histone H2A.Z expression is mediated by sirtuin 1 in prostate cancer

https://doi.org/10.18632/oncotarget.1237

Tiago Baptista, Inês Graça, Elsa J Sousa, Ana I Oliveira, Natália R Costa, Pedro Costa-Pinheiro, Francisco Amado, Rui Henrique,  and Carmen Jeronimo
1673-1685
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Altered glycosylation of MUC1 influences its association with CIN85: the role of this novel complex in cancer cell invasion and migration

Altered glycosylation of MUC1 influences its association with CIN85: the role of this novel complex in cancer cell invasion and migration

https://doi.org/10.18632/oncotarget.1265

Sandra Cascio, Adam M Farkas, Rebecca P Hughey,  and Olivera J Finn
1686-1697
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Lung cancer tumorigenicity and drug resistance are maintained through ALDHhi CD44hi tumor initiating cells

Lung cancer tumorigenicity and drug resistance are maintained through ALDHhi CD44hi tumor initiating cells

https://doi.org/10.18632/oncotarget.1246

Jing Liu, Zhijie Xiao, Sunny Kit-Man Wong, Vicky Pui-Chi Tin, Ka-Yan Ho, Junwen Wang, Mai-Har Sham,  and Maria Pik Wong
1698-1711
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

DHH-RHEBL1 fusion transcript: a novel recurrent feature in the new landscape of pediatric CBFA2T3-GLIS2-positive acute myeloid leukemia

DHH-RHEBL1 fusion transcript: a novel recurrent feature in the new landscape of pediatric CBFA2T3-GLIS2-positive acute myeloid leukemia

https://doi.org/10.18632/oncotarget.1280

Riccardo Masetti, Marco Togni, Annalisa Astolfi, Martina Pigazzi, Elena Manara, Valentina Indio, Carmelo Rizzari, Sergio Rutella, Giuseppe Basso, Andrea Pession,  and Franco Locatelli
1712-1720
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Substantial expression of luteinizing hormone-releasing hormone (LHRH) receptor type I in human uveal melanoma

Substantial expression of luteinizing hormone-releasing hormone (LHRH) receptor type I in human uveal melanoma

https://doi.org/10.18632/oncotarget.1379

Andrea Treszl, Zita Steiber, Andrew V Schally, Norman L Block, Balazs Dezso, Gabor Olah, Bernadett Rozsa, Klara Fodor, Armin Buglyo, Janos Gardi, Andras Berta,  and Gabor Halmos
1721-1728
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Efficient induction of differentiation and growth inhibition in IDH1 mutant glioma cells by the DNMT Inhibitor Decitabine.

Efficient induction of differentiation and growth inhibition in IDH1 mutant glioma cells by the DNMT Inhibitor Decitabine.

https://doi.org/10.18632/oncotarget.1412

Sevin Turcan, Armida WM Fabius, Alexandra Borodovsky, Alicia Pedraza, Cameron Brennan, Jason Huse, Agnes Viale, Gregory J Riggins,  and Timothy A Chan
1729-1736
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5-azacytidine reduces methylation, promotes differentiation and induces tumor regression in a patient-derived IDH1 mutant glioma xenograft

5-azacytidine reduces methylation, promotes differentiation and induces tumor regression in a patient-derived IDH1 mutant glioma xenograft

https://doi.org/10.18632/oncotarget.1408

Alexandra Borodovsky, Vafi Salmasi, Sevin Turcan, Armida W. M. Fabius, Gilson Baia, Charles G Eberhart, Jon D. Weingart, Gary L Gallia, Stephen B Baylin, Timothy A Chan,  and Gregory J Riggins
1737-1747
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CCAT2, a novel long non-coding RNA in breast cancer: expression study and clinical correlations

CCAT2, a novel long non-coding RNA in breast cancer: expression study and clinical correlations

https://doi.org/10.18632/oncotarget.1292

Roxana S Redis, Anieta M Siewerts, Maxime P Look, Oana Tudoran, Cristina Ivan, Riccardo Spizzo, Xinna Zhang, Vanja de Weerd, Masayoshi Shimizu, Hui Ling, Rares Buiga, Victor Pop, Alexandru Irimie, Riccardo Fodde, Isabella Bedrosian, John WM Martens, John A Foekens, Ioana Berindan-Neagoe,  and George A Calin
1748-1762
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Identification of novel small molecule inhibitors of centrosome clustering in cancer cells

Identification of novel small molecule inhibitors of centrosome clustering in cancer cells

https://doi.org/10.18632/oncotarget.1198

Eiko Kawamura, Andrew B. Fielding, Nagarajan Kannan, Aruna Balgi, Connie J. Eaves, Michel Roberge,  and Shoukat Dedhar
1763-1776
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Immunological targeting of tumor cells undergoing an epithelial-mesenchymal transition via a recombinant brachyury-yeast vaccine

Immunological targeting of tumor cells undergoing an epithelial-mesenchymal transition via a recombinant brachyury-yeast vaccine

https://doi.org/10.18632/oncotarget.1295

Duane H. Hamilton, Mary T. Litzinger, Alessandra Jales, Bruce Huang, Romaine I. Fernando, James W. Hodge, Andressa Ardiani, David Apelian, Jeffrey Schlom,  and Claudia Palena
1777-1790
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Upregulation of adenylate cyclase 3 (ADCY3) increases the tumorigenic potential of cells by activating the CREB pathway

Upregulation of adenylate cyclase 3 (ADCY3) increases the tumorigenic potential of cells by activating the CREB pathway

https://doi.org/10.18632/oncotarget.1324

Seung-Hyun Hong, Sung-Ho Goh, Sang-Jin Lee, Jung-Ah Hwang, Jieun Lee, Il-Ju Choi, Hyehyun Seo, Jong-Hoon Park, Hiromu Suzuki, Eiichiro Yamamoto, In-Hoo Kim, Jin Sook Jeong, Mi Ha Ju, Dong-Hee Lee,  and Yeon-Su Lee
1791-1803
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Cholesterol-induced mammary tumorigenesis is enhanced by adiponectin deficiency: role of LDL receptor upregulation

Cholesterol-induced mammary tumorigenesis is enhanced by adiponectin deficiency: role of LDL receptor upregulation

https://doi.org/10.18632/oncotarget.1364

Jing Liu, Aimin Xu, Karen Siu-Ling Lam, Nai-Sum Wong, Jie Chen, Peter R R Shepherd,  and Yu Wang
1804-1818
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Identification of a novel peptide that blocks basic fibroblast growth factor-mediated cell proliferation

Identification of a novel peptide that blocks basic fibroblast growth factor-mediated cell proliferation

https://doi.org/10.18632/oncotarget.1312

Xiaoping Wu, Huixian Huang, Cong Wang, Shaoqiang Lin, Yadong Huang, Yi Wang, Guang Liang, Qiuxia Yan, Jian Xiao, Jianzhang Wu, Yongguang Yang,  and Xiaokun Li
1819-1828
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Broad-spectrum anti-tumor and anti-metastatic DNA vaccine based on p62-encoding vector

Broad-spectrum anti-tumor and anti-metastatic DNA vaccine based on p62-encoding vector

https://doi.org/10.18632/oncotarget.1397

Franco Venanzi, Victor Shifrin, Michael Y. Sherman, Vladimir Gabai, Oleg Kisilev, Andrey Komissarov, Mikhail Grudinin, Maria Shartakova, Ekaterina Romanovskaya-Romanko, Yuri Kudryavets, Natalya Bezdenezhnykh, Oleksandra Lykhova, Nadiia Semesyuk, Antonio Concetti, Anatoly Tsyb, Marina Filimonova, Victoria Makarchuk, Raisa Yakubovsky, Andrey Chursov, Vita Shcherbinina,  and Alexander Shneider
1829-1835
Abstract  |  PDF  |  HTML  |  Order a Reprint

The deubiquitinating enzyme USP17 is associated with non-small cell lung cancer (NSCLC) recurrence and metastasis

The deubiquitinating enzyme USP17 is associated with non-small cell lung cancer (NSCLC) recurrence and metastasis

https://doi.org/10.18632/oncotarget.1282

Cheryl McFarlane, Suzanne McFarlane, Ian Paul, Kenneth Arthur, Michael Scheaff, Keith Kerr, Michael Stevenson, Dean A Fennell,  and James A Johnston
1836-1843
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PTRF/Cavin-1 decreases prostate cancer angiogenesis and lymphangiogenesis

PTRF/Cavin-1 decreases prostate cancer angiogenesis and lymphangiogenesis

https://doi.org/10.18632/oncotarget.1300

Zeyad D Nassar, Hyeongsun Moon, Tam Duong, LiQi Neo, Michelle M Hill, Mathias Francois, Robert G Parton,  and Marie-Odile Parat
1844-1855
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Letters to the Editor

Insights into therapeutic resistance from whole-genome analyses of circulating tumor DNA

Insights into therapeutic resistance from whole-genome analyses of circulating tumor DNA

https://doi.org/10.18632/oncotarget.1486

Luis A. Diaz, Jr, Mark Sausen, George A. Fisher,  and Victor E. Velculescu
1856-1857
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