Oncotarget

Vol 4, No 8

August 2013

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About The Cover

Visualizing Two-Compartment Tumor Metabolism, with Metabolic Marker Proteins: MCT4 and TOMM20. Human breast cancer samples (from primary tumors or lymph node metastases) were immuno-stained with antibodies directed against MCT4 (shown in RED) and TOMM20 (shown in BROWN). Image was digitaly enhanced for the cover of Oncotarget. See Sotgia et al.

Table of Contents

Editorial

Adoptive T-cell therapy to treat liver cancer: Is the liver microenvironment key?

Adoptive T-cell therapy to treat liver cancer: Is the liver microenvironment key?

https://doi.org/10.18632/oncotarget.1179

Gerald Willimsky, Ulrike Protzer, Percy Knolle,  and Mathias Heikenwalder
1117-1118
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Cancer detection using whole-genome sequencing of cell free DNA

Cancer detection using whole-genome sequencing of cell free DNA

https://doi.org/10.18632/oncotarget.1183

Rebecca J. Leary, Mark Sausen, Luis A. Diaz, Jr.,  and Victor E. Velculescu
1119-1120
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Regulation of Mdm2 mRNA Stability by RNA-binding Protein RNPC1

Regulation of Mdm2 mRNA Stability by RNA-binding Protein RNPC1

https://doi.org/10.18632/oncotarget.1185

Jin Zhang, Enshun Xu,  and Xinbin Chen
1121-1122
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Restoring hemidesmosomes to prevent cancer cell invasiveness

Restoring hemidesmosomes to prevent cancer cell invasiveness

https://doi.org/10.18632/oncotarget.1196

S. Pyronnet, J. Guillermet-Guibert,  and C. Bousquet
1123-1124
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ATM is activated in blood monocytes after tumor radiation.

ATM is activated in blood monocytes after tumor radiation.

https://doi.org/10.18632/oncotarget.1286

Andrei V. Gudkov,  and Elena A. Komarova
1125
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Editorial Broadcast

A new Achilles Heel in breast cancer?

A new Achilles Heel in breast cancer?

https://doi.org/10.18632/oncotarget.1178

George Sflomos,  and Cathrin Brisken
1126-1127
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Overcoming treatment resistance in acute promyelocytic leukemia and beyond

Overcoming treatment resistance in acute promyelocytic leukemia and beyond

https://doi.org/10.18632/oncotarget.1244

Tsz Kan Fung,  and Chi Wai Eric So
1128-1129
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Reviews

Understanding the role of NRF2-regulated miRNAs in human malignancies

Understanding the role of NRF2-regulated miRNAs in human malignancies

https://doi.org/10.18632/oncotarget.1181

Niraj M Shah, Stuart A Rushworth, Megan Y Murray, Kristian M Bowles,  and David J MacEwan
1130-1142
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Research Papers

Radiation therapy induces the DNA damage response in peripheral blood

Radiation therapy induces the DNA damage response in peripheral blood

https://doi.org/10.18632/oncotarget.1084

Christopher J Bakkenist, R Kenneth Czambel, David A Clump, Joel S Greenberger, Jan H Beumer,  and John C Schmitz
1143-1148
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Gli1 Transcriptional Activity is Negatively Regulated by AKT2 in Neuroblastoma

Gli1 Transcriptional Activity is Negatively Regulated by AKT2 in Neuroblastoma

https://doi.org/10.18632/oncotarget.1074

Pritha Paul, Natasha S. Volny, Sora Lee, Jingbo Qiao,  and Dai H. Chung
1149-1157
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Targeting mixed lineage kinases in ER-positive breast cancer cells leads to G2/M cell cycle arrest and apoptosis.

Targeting mixed lineage kinases in ER-positive breast cancer cells leads to G2/M cell cycle arrest and apoptosis.

https://doi.org/10.18632/oncotarget.1093

Limin Wang, Kathleen A Gallo,  and Susan E Conrad
1158-1171
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Identification of pregnancy-associated plasma protein A as a migration-promoting gene in malignant pleural mesothelioma cells: a potential therapeutic target

Identification of pregnancy-associated plasma protein A as a migration-promoting gene in malignant pleural mesothelioma cells: a potential therapeutic target

https://doi.org/10.18632/oncotarget.1126

Jun Huang, Sho Tabata, Soji Kakiuchi, Trung The Van, Hisatsugu Goto, Masaki Hanibuchi,  and Yasuhiko Nishioka
1172-1184
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Combining TRAIL with PI3 kinase or HSP90 inhibitors enhances apoptosis in colorectal cancer cells via suppression of survival signaling

Combining TRAIL with PI3 kinase or HSP90 inhibitors enhances apoptosis in colorectal cancer cells via suppression of survival signaling

https://doi.org/10.18632/oncotarget.1162

Grazia Saturno, Melanie Valenti, Alexis De Haven Brandon, George V. Thomas, Suzanne Eccles, Paul A. Clarke,  and Paul Workman
1185-1198
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Annexin A2 is regulated by ovarian cancer-peritoneal cell interactions and promotes metastasis

Annexin A2 is regulated by ovarian cancer-peritoneal cell interactions and promotes metastasis

https://doi.org/10.18632/oncotarget.1122

Noor A. Lokman, Alison SF. Elder, Miranda P Ween, Carmen E. Pyragius, Peter Hoffmann, Martin K. Oehler,  and Carmela Ricciardelli
1199-1211
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Small Molecule-Induced Mitochondrial Disruption Directs Prostate Cancer Inhibition via Unfolded Protein Response Signaling

Small Molecule-Induced Mitochondrial Disruption Directs Prostate Cancer Inhibition via Unfolded Protein Response Signaling

https://doi.org/10.18632/oncotarget.1130

Elizabeth Rico-Bautista, Wenhong Zhu, Shinichi Kitada, Suthakar Ganapathy, Eric Lau, Stan Krajewski, Joel Ramirez, Jason A. Bush, Zhimin Yuan,  and Dieter A. Wolf
1212-1229
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Clonogenic multiple myeloma cells have shared stemness signature associated with patient survival

Clonogenic multiple myeloma cells have shared stemness signature associated with patient survival

https://doi.org/10.18632/oncotarget.1145

Renji Reghunathan, Chonglei Bi, Shaw Cheng Liu, Koh Tze Loong, Tae-Hoon Chung, Gaofeng Huang,  and Wee Joo Chng
1230-1240
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A novel Mcl1 variant inhibits apoptosis via increased Bim sequestration

A novel Mcl1 variant inhibits apoptosis via increased Bim sequestration

https://doi.org/10.18632/oncotarget.1147

Judith Hagenbuchner, Ursula Kiechl-Kohlendorfer, Petra Obexer,  and Michael J. Ausserlechner
1241-1252
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Combination therapy with anti-ErbB3 monoclonal antibodies and EGFR TKIs potently inhibits Non-small Cell Lung Cancer

Combination therapy with anti-ErbB3 monoclonal antibodies and EGFR TKIs potently inhibits Non-small Cell Lung Cancer

https://doi.org/10.18632/oncotarget.1141

Alessia Noto, Claudia De Vitis, Giuseppe Roscilli, Luigi Fattore, Debora Malpicci, Emanuele Marra, Laura Luberto, Antonio D'Andrilli, Pierpaolo Coluccia, Maria Rosaria Giovagnoli, Nicola Normanno, Luigi Ruco, Luigi Aurisicchio, Rita Mancini,  and Gennaro Ciliberto
1253-1265
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PTEN loss represses glioblastoma tumor initiating cell differentiation via inactivation of Lgl1

PTEN loss represses glioblastoma tumor initiating cell differentiation via inactivation of Lgl1

https://doi.org/10.18632/oncotarget.1164

Alexander Gont, Jennifer E. L. Hanson, Sylvie J. Lavictoire, Doris A. E. Parolin, Manijeh Daneshmand, Ian J. restall, Mathieu Soucie, Garth Nicholas, John Woulfe, Amin Kassam, Vasco F. Da Silva,  and Ian A. J. Lorimer
1266-1279
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Critical role of zinc finger protein 521 in the control of growth, clonogenicity and tumorigenic potential of medulloblastoma cells.

Critical role of zinc finger protein 521 in the control of growth, clonogenicity and tumorigenic potential of medulloblastoma cells.

https://doi.org/10.18632/oncotarget.1176

Raffaella Spina, Gessica Filocamo, Enrico Iaccino, Stefania Scicchitano, Michela Lupia, Emanuela Chiarella, Tiziana Mega, Francesca Bernaudo, Daniela Pelaggi, Maria Mesuraca, Simonetta Pazzaglia, Samantha Semenkow, Eli E Bar, Marcel Kool, Stefan Pfister, Heather M Bond, Charles G Eberhart, Christian Steinkühler,  and Giovanni Morrone
1280-1292
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HMGA1 promotes metastatic processes in basal-like breast cancer regulating EMT and stemness

HMGA1 promotes metastatic processes in basal-like breast cancer regulating EMT and stemness

https://doi.org/10.18632/oncotarget.1136

Silvia Pegoraro, Gloria Ros, Silvano Piazza, Roberta Sommaggio, Yari Ciani, Antonio Rosato, Riccardo Sgarra, Giannino Del Sal,  and Guidalberto Manfioletti
1293-1308
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Research Perspectives

Cancer Metabolism: New Validated Targets for Drug Discovery

Cancer Metabolism: New Validated Targets for Drug Discovery

https://doi.org/10.18632/oncotarget.1182

Federica Sotgia, Ubaldo E. Martinez-Outschoorn,  and Michael P Lisanti
1309-1316
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A Tumor initiating cell-enriched prognostic signature for HER2+:ERα- breast cancer; rationale, new features, controversies and future directions

A Tumor initiating cell-enriched prognostic signature for HER2+:ERα- breast cancer; rationale, new features, controversies and future directions

https://doi.org/10.18632/oncotarget.1170

Jeff C. Liu, Sean E. Egan,  and Eldad Zacksenhaus
1317-1328
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