Oncotarget

Vol 4, No 1

January 2013

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About The Cover

Targeted radiation therapy disrupts the Brain Tumor’s blood-brain barrier and permits greater penetration of the filomicelle nanocarrier. In Figure 2 (F), Cranial RT is delivered using a novel mouse restrainer and the Small Animal Radiation Research Platform (SARRP). See Baumann et al.

Table of Contents

Editorial

Protease nexin 1: a novel regulator of prostate cancer cell growth and neo-angiogenesis

Protease nexin 1: a novel regulator of prostate cancer cell growth and neo-angiogenesis

DOI: 10.18632/oncotarget.824

Chad M. McKee, Danmei Xu,  and Ruth J. Muschel
1-2
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Targeting glycogen metabolism: a novel strategy to inhibit cancer cell growth?

Targeting glycogen metabolism: a novel strategy to inhibit cancer cell growth?

DOI: 10.18632/oncotarget.841

Elena Favaro,  and Adrian L. Harris
3-4
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The limited contribution of DNA methylation to PML-RARα induced leukemia

The limited contribution of DNA methylation to PML-RARα induced leukemia

DOI: 10.18632/oncotarget.875

Christian Rohde, Till Schoofs,  and Carsten Müller-Tidow
5-6
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New concepts for CML clonality

New concepts for CML clonality

DOI: 10.18632/oncotarget.882

Jamshid S. Khorashad, Michael W. Deininger,  and Thomas O’Hare
7-8
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Research Papers

MET amplification as a potential therapeutic target in gastric cancer

MET amplification as a potential therapeutic target in gastric cancer

DOI: 10.18632/oncotarget.718

Hisato Kawakami, Isamu Okamoto, Tokuzo Arao, Wataru Okamoto, Kazuko Matsumoto, Hirokazu Taniguchi, Kiyoko Kuwata, Haruka Yamaguchi, Kazuto Nishio, Kazuhiko Nakagawa,  and Yasuhide Yamada
9-17
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KDM1 is a novel therapeutic target for the treatment of gliomas

KDM1 is a novel therapeutic target for the treatment of gliomas

DOI: 10.18632/oncotarget.725

Gangadhara R Sareddy, Binoj C. Nair, Samaya K Krishnan, Vijay K Gonugunta, Quan-guang Zhang, Naoki Miyata, Takayoshi Suzuki, Andrew Brenner, Darrell W Brann,  and Ratna K Vadlamudi
18-28
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Functional analysis of non-hotspot AKT1 mutants found in human breast cancers identifies novel driver mutations: implications for personalized medicine

Functional analysis of non-hotspot AKT1 mutants found in human breast cancers identifies novel driver mutations: implications for personalized medicine

DOI: 10.18632/oncotarget.755

Kyung H Yi, Jossette Axtmayer, John P Gustin, Anandita Rajpurohit,  and Josh Lauring
29-34
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SOCS1 Mutation Subtypes Predict Divergent Outcomes in Diffuse Large B-Cell Lymphoma (DLBCL) Patients

SOCS1 Mutation Subtypes Predict Divergent Outcomes in Diffuse Large B-Cell Lymphoma (DLBCL) Patients

DOI: 10.18632/oncotarget.774

Birgit Schif, Jochen K Lennerz, Christian W Kohler, Markus Kreuz, Stefan Bentink, Ingo Melzner, Olga Ritz, Lorenz Trümper, Markus Löffler, Rainer Spang,  and Peter Möller
35-47
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High-throughput RNAi screening for novel modulators of vimentin expression identifies MTHFD2 as a regulator of breast cancer cell migration and invasion

High-throughput RNAi screening for novel modulators of vimentin expression identifies MTHFD2 as a regulator of breast cancer cell migration and invasion

DOI: 10.18632/oncotarget.756

Laura Lehtinen, Kirsi Ketola, Rami Mäkelä, John-Patrick Mpindi, Miro Viitala, Olli Kallioniemi,  and Kristiina Iljin
48-63
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Enhancing the Efficacy of Drug-loaded Nanocarriers against Brain Tumors by Targeted Radiation Therapy

Enhancing the Efficacy of Drug-loaded Nanocarriers against Brain Tumors by Targeted Radiation Therapy

DOI: 10.18632/oncotarget.777

Brian C. Baumann, Gary D. Kao, Abdullah Mahmud, Takamasa Harada, Joe Swift, Christina Chapman, Xiangsheng Xu, Dennis E. Discher,  and Jay F. Dorsey
64-79
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Genomic imbalance of HMMR/RHAMM regulates the sensitivity and response of malignant peripheral nerve sheath tumour cells to aurora kinase inhibition.

Genomic imbalance of HMMR/RHAMM regulates the sensitivity and response of malignant peripheral nerve sheath tumour cells to aurora kinase inhibition.

DOI: 10.18632/oncotarget.793

Pooja Mohan, Joan Castellsague, Jihong Jiang, Kristi Allen, Helen Chen, Oksana Nemirovsky, Melanie Spyra, Kaiji Hu, Lan Kluwe, Miguel Angel Pujana, Alberto Villanueva, Victor F. Mautner, Jonathan J. Keats, Sandra E. Dunn, Conxi Lazaro,  and Christopher A. Maxwell
80-93
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Intraductal Delivery of Adenoviruses Targets Pancreatic Tumors in Transgenic Ela-myc Mice and Orthotopic Xenografts

Intraductal Delivery of Adenoviruses Targets Pancreatic Tumors in Transgenic Ela-myc Mice and Orthotopic Xenografts

DOI: 10.18632/oncotarget.795

Anabel José, Luciano Sobrevals, Juan Miguel Camacho-Sánchez, Meritxell Huch, Núria Andreu, Eduard Ayuso, Pilar Navarro, Ramon Alemany,  and Cristina Fillat
94-105
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Quantification of Mesenchymal Stem Cells (MSCs) at Sites of Human Prostate Cancer

Quantification of Mesenchymal Stem Cells (MSCs) at Sites of Human Prostate Cancer

DOI: 10.18632/oncotarget.805

W. Nathaniel Brennen, Shuangling Chen, Samuel R. Denmeade,  and John T. Isaacs
106-117
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Dual EGFR inhibition in combination with anti-VEGF treatment: A phase I clinical trial in non-small cell lung cancer

Dual EGFR inhibition in combination with anti-VEGF treatment: A phase I clinical trial in non-small cell lung cancer

DOI: 10.18632/oncotarget.763

Gerald S. Falchook, Aung Naing, David S. Hong, Ralph G. Zinner, Siqing Fu, Sarina A. Piha-Paul, Apostolia M. Tsimberidou, Sonia K. Morgan-Linnell, Yunfang Jiang, Christel C. Bastida, Jennifer J. Wheler,  and Razelle Kurzrock
118-127
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Altered transcriptome signature of phenotypically normal skin fibroblasts heterozygous for CDKN2A in familial melanoma: relevance to early intervention

Altered transcriptome signature of phenotypically normal skin fibroblasts heterozygous for CDKN2A in familial melanoma: relevance to early intervention

DOI: 10.18632/oncotarget.786

Meiyun Fan, Susan R. Pfeffer, Henry T. Lynch, Pamela Cassidy, Sancy Leachman, Lawrence M. Pfeffer,  and Levy Kopelovich
128-141
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Ras inhibition enhances autophagy, which partially protects cells from death

Ras inhibition enhances autophagy, which partially protects cells from death

DOI: 10.18632/oncotarget.703

Eran Schmukler, Efrat Grinboim, Sari Schokoroy, Adva Amir, Eya Wolfson, Yoel Kloog,  and Ronit Pinkas-Kramarski
142-152
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Targeted Therapy of Advanced Gallbladder Cancer and Cholangiocarcinoma with Aggressive Biology: Eliciting Early Response Signals from Phase 1 trials

Targeted Therapy of Advanced Gallbladder Cancer and Cholangiocarcinoma with Aggressive Biology: Eliciting Early Response Signals from Phase 1 trials

DOI: 10.18632/oncotarget.832

Ishwaria Subbiah, Vivek Subbiah, Apostolia M Tsimberidou, Aung Naing, Ahmed Kaseb, Javle Milind, Siqing Fu, David S Hong, Sarina Piha-Paul, Jenifer Wheler, Kenneth Hess, Filip Janku, Gerald Falchook, Robert A Wolff,  and Razelle Kurzrock
153-162
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TIMP-2 modulates cancer cell transcriptional profile and enhances E-cadherin/beta-catenin complex expression in A549 lung cancer cells

TIMP-2 modulates cancer cell transcriptional profile and enhances E-cadherin/beta-catenin complex expression in A549 lung cancer cells

DOI: 10.18632/oncotarget.801

Dimitra Bourboulia, HuiYing Han, Sandra Jensen-Taubman, Noah Gavil, Biju Isaac, Beiyang Wei, Len Neckers,  and William Stetler-Stevenson
163-173
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