Oncotarget

Vol 3, No 10

October 2012

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About The Cover

The October cover of Oncotarget depicts a phenotype of zebrafish injected with CIC MO. The knock-down of CIC results in mitochondrial DNA depletion and activation of autophagy. See Catalina-Rodriguez et al.

Table of Contents

Editorial

Targeting SHP2 phosphatase in Myeloproliferative Neoplasms

Targeting SHP2 phosphatase in Myeloproliferative Neoplasms

https://doi.org/10.18632/oncotarget.665

Raghuveer Singh Mali, Rebecca Chan,  and Reuben Kapur
1049-1051
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p53 as a target in myeloproliferative neoplasms

p53 as a target in myeloproliferative neoplasms

https://doi.org/10.18632/oncotarget.719

Min Lu,  and Ronald Hoffman
1052-1053
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Inhibiting the molecular evolution of cancer through HSP90

Inhibiting the molecular evolution of cancer through HSP90

https://doi.org/10.18632/oncotarget.738

Ana Sofia Martins, Faith E. Davies,  and Paul Workman
1054-1056
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Regulation of the p53 by Helicobacter pylori.

Regulation of the p53 by Helicobacter pylori.

https://doi.org/10.18632/oncotarget.698

Alexander Zaika, Jinxiong Wei, Jennifer Noto,  and Richard Peek, Jr
1057-1058
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HLX in AML: novel prognostic and therapeutic target

HLX in AML: novel prognostic and therapeutic target

https://doi.org/10.18632/oncotarget.705

Ashley Pandolfi,  and Ulrich Steidl
1059-1060
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Exploiting the mTOR paradox for disease prevention

Exploiting the mTOR paradox for disease prevention

https://doi.org/10.18632/oncotarget.712

Ramiro Iglesias-Bartolome,  and J. Silvio Gutkind
1061-1063
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Too much AKT turns PAX3-FKHR dead: A prospect of novel therapeutic strategy for alveolar rhabdomyosarcoma

Too much AKT turns PAX3-FKHR dead: A prospect of novel therapeutic strategy for alveolar rhabdomyosarcoma

https://doi.org/10.18632/oncotarget.713

Mathivanan Jothi,  and Asoke K. Mal
1064-1065
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Burkitt lymphomagenesis linked to MYC plus PI3K in germinal center B cells

Burkitt lymphomagenesis linked to MYC plus PI3K in germinal center B cells

https://doi.org/10.18632/oncotarget.726

Sandrine Sander,  and Klaus Rajewsky
1066-1067
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Reviews

Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascade Inhibitors: How Mutations Can Result in Therapy Resistance and How to Overcome Resistance

Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascade Inhibitors: How Mutations Can Result in Therapy Resistance and How to Overcome Resistance

https://doi.org/10.18632/oncotarget.659

James Andrew McCubrey, Linda S. Steelman, William H. Chappell, Stephen L. Abrams, Richard A. Franklin, Giuseppe Montalto, Melchiorre Cervello, Massimo Libra, Saverio Candido, Grazia Malaponte, Maria C. Mazzarino, Paolo Fagone, Ferdinando Nicoletti, Jörg Bäsecke, Sanja Mijatovic, Danijela Maksimovic-Ivanic, Michele Milella, Agostino Tafuri, Francesca Chiarini, Camilla Evangelisti, Lucio Cocco,  and Alberto M. Martelli
1068-1111
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Research: Complementary Reports

Disulfiram, a drug widely used to control alcoholism, suppresses the self-renewal of glioblastoma and over-rides resistance to temozolomide

Disulfiram, a drug widely used to control alcoholism, suppresses the self-renewal of glioblastoma and over-rides resistance to temozolomide

https://doi.org/10.18632/oncotarget.604

Joanna Triscott, Cathy Lee, Kaiji Hu, Abbas Fotovati, Rachel Berns, Mary Pambid, Margaret Luk, Richard E Kast, Esther Kong, Eric Toyota, Stephen Yip, Brian Toyota,  and Sandra E Dunn
1112-1123
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High-Throughput Chemical Screens Identify Disulfiram as an Inhibitor of Human Glioblastoma Stem Cells

High-Throughput Chemical Screens Identify Disulfiram as an Inhibitor of Human Glioblastoma Stem Cells

https://doi.org/10.18632/oncotarget.707

Parvinder Hothi, Timothy J. Martins, LiPing Chen, Loic Deleyrolle, Jae-Geun Yoon, Brent Reynolds,  and Greg Foltz
1124-1136
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Research Papers

High cytidine deaminase expression in the liver provides sanctuary for cancer cells from decitabine treatment effects

High cytidine deaminase expression in the liver provides sanctuary for cancer cells from decitabine treatment effects

https://doi.org/10.18632/oncotarget.597

Quteba Ebrahem, Reda Z Mahfouz, Kwok Peng Ng,  and Yogen Saunthararajah
1137-1145
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FOXP3, a novel glioblastoma oncosuppressor, affects proliferation and migration

FOXP3, a novel glioblastoma oncosuppressor, affects proliferation and migration

https://doi.org/10.18632/oncotarget.644

Véronique Frattini, Federica Pisati, Maria Carmela Speranza, Pietro Luigi Poliani, Gianmaria Frigé, Gabriele Cantini, Dimos Kapetis, Manuela Cominelli, Alessandra Rossi, Gaetano Finocchiaro,  and Serena Pellegatta
1146-1157
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Heat Shock Protein 90 is overexpressed in high-risk myelodysplastic syndromes and associated with higher expression and activation of Focal Adhesion Kinase

Heat Shock Protein 90 is overexpressed in high-risk myelodysplastic syndromes and associated with higher expression and activation of Focal Adhesion Kinase

https://doi.org/10.18632/oncotarget.557

Pascale Flandrin-Gresta, Francoise Solly, Carmen Mariana Aanei, Jerome Cornillon, Emmanuelle Tavernier, Nathalie Nadal, Franck Morteux, Denis Guyotat, Eric Wattel,  and Lydia Campos
1158-1168
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Targeting JNK-interacting-protein-1 (JIP1) sensitises osteosarcoma to doxorubicin

Targeting JNK-interacting-protein-1 (JIP1) sensitises osteosarcoma to doxorubicin

https://doi.org/10.18632/oncotarget.600

Jantine PosthumadeBoer, Pim W. van Egmond, Marco N. Helder, Renée X. de Menezes, Anne-Marie Cleton-Jansen, Jeroen A.M. Beliën, Henk M.W. Verheul, Barend J. van Royen, Gert-Jan J.L. Kaspers,  and Victor W. van Beusechem
1169-1181
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Up-regulation of c-MYC and SIRT1 expression correlates with malignant transformation in the serrated route to colorectal cancer

Up-regulation of c-MYC and SIRT1 expression correlates with malignant transformation in the serrated route to colorectal cancer

https://doi.org/10.18632/oncotarget.628

Lydia Kriegl, Michael Vieth, Thomas Kirchner,  and Antje Menssen
1182-1193
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Whole-exome sequencing identifies ATRX mutation as a key molecular determinant in lower-grade glioma

Whole-exome sequencing identifies ATRX mutation as a key molecular determinant in lower-grade glioma

https://doi.org/10.18632/oncotarget.689

Kasthuri Kannan, Akiko Inagaki, Joachim Silber, Daniel Gorovets, Jianan Zhang, Edward R. Kastenhuber, Adriana Heguy, John H. Petrini, Timothy A. Chan,  and Jason T. Huse
1194-1203
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Reactivation of codogenic endogenous retroviral (ERV) envelope genes in human endometrial carcinoma and prestages: Emergence of new molecular targets.

Reactivation of codogenic endogenous retroviral (ERV) envelope genes in human endometrial carcinoma and prestages: Emergence of new molecular targets.

https://doi.org/10.18632/oncotarget.679

Pamela L. Strissel, Matthias Ruebner, Falk Thiel, David Wachter, Arif B. Ekici, Friedericke Wolf, Franziska Thieme, Klemens Ruprecht, Matthias W. Beckmann,  and Reiner Strick
1204-1219
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The mitochondrial citrate transporter, CIC, is essential for mitochondrial homeostasis.

The mitochondrial citrate transporter, CIC, is essential for mitochondrial homeostasis.

https://doi.org/10.18632/oncotarget.714

Olga Catalina-Rodriguez, Vamsi K. Kolukula, York Tomita, Anju Preet, Ferdinando Palmieri, Anton Wellstein, Stephen Byers, Amato J. Giaccia, Eric Glasgow, Chris Albanese,  and Maria Laura Avantaggiati
1220-1235
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Effects of Ectopic Expression of NGAL on Doxorubicin Sensitivity.

Effects of Ectopic Expression of NGAL on Doxorubicin Sensitivity.

https://doi.org/10.18632/oncotarget.691

William H Chappell, Stephen L. Abrams, Richard A Franklin, Giuseppe Montalto, Melchiorre Cervello, Alberto M Martelli, Saverio Candido, Massimo Libra, Jerry Polesel, Renato Talamini, Ralph Arlinghaus, Linda S Steelman,  and James A McCubrey
1236-1245
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DNA-demethylating and anti-tumor activity of synthetic miR-29b mimics in multiple myeloma

DNA-demethylating and anti-tumor activity of synthetic miR-29b mimics in multiple myeloma

https://doi.org/10.18632/oncotarget.675

Nicola Amodio, Marzia Leotta, Dina Bellizzi, Maria Teresa Di Martino, Patrizia D'Aquila, Marta Lionetti, Fernanda Fabiani, Emanuela Leone, Anna Maria Gullà, Giuseppe Passarino, Michele Caraglia, Massimo Negrini, Antonino Neri, Antonio Giordano, Pierosandro Tagliaferri,  and Pierfrancesco Tassone
1246-1258
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