Oncotarget

Vol 3, No 2

February 2012

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About The Cover

PRL-3 chimeric mAb recognizes EGFP-PRL-3 overexpressed in DLD-1 human colorectal cancer cells by indirect immunofluorescence. Shown is the composite  image of EGFP-PRL-3 in fixed DLD-1 cells (green) and PRL-3 chimeric antibody together with an image of anti-human IgG Texas-Red (red) to reveal the binding to PRL-3 protein. See  Guo et al.

Table of Contents

Editorial Comments

c-MYC and SIRT1 locked in a vicious cycle

c-MYC and SIRT1 locked in a vicious cycle

https://doi.org/10.18632/oncotarget.440

Antje Menssen,  and Heiko Hermeking
112-113
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Modulating Mesothelin Shedding to Improve Therapy

Modulating Mesothelin Shedding to Improve Therapy

https://doi.org/10.18632/oncotarget.445

Ira Pastan,  and Yujian Zhang
114-115
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Bryostatin analog: improving on Nature’s design

Bryostatin analog: improving on Nature’s design

https://doi.org/10.18632/oncotarget.460

Dale Boger
116-117
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Reviews

Targeting Mnks for Cancer Therapy

Targeting Mnks for Cancer Therapy

https://doi.org/10.18632/oncotarget.453

Jinqiang Hou, Frankie Kam, Christopher G Proud,  and Shudong Wang
118-131
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Brief Reports

Gain-of-function p53 mutants have widespread genomic locations partially overlapping with p63.

Gain-of-function p53 mutants have widespread genomic locations partially overlapping with p63.

https://doi.org/10.18632/oncotarget.447

Elena Martynova, Silvia Pozzi, Valentina Basile, Diletta Dolfini, Federico Zambelli, Carol Imbriano, Giulio Pavesi,  and Roberto Mantovani
132-143
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Research Papers

Ras inhibition by FTS attenuates brain tumor growth in mice by direct antitumor activity and enhanced reactivity of cytotoxic lymphocytes

Ras inhibition by FTS attenuates brain tumor growth in mice by direct antitumor activity and enhanced reactivity of cytotoxic lymphocytes

https://doi.org/10.18632/oncotarget.420

Elizabeta Aizman, Adi Mor, Ayelet Levy, Jacob George,  and Yoel Kloog
144-157
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Engineering the First Chimeric Antibody in Targeting Intracellular PRL-3 Oncoprotein for Cancer Therapy in Mice

Engineering the First Chimeric Antibody in Targeting Intracellular PRL-3 Oncoprotein for Cancer Therapy in Mice

https://doi.org/10.18632/oncotarget.442

Ke Guo, Jing Ping Tang, Jie Li, Cheng Peow Tan, Abdul Qader O. Al-Aidaroos, Cheng William Hong, Leyon Varghese, Zhi Wei Feng, Jung Eun Park, Jian Biao Zhou, Wee Joo Chng,  and Qi Zeng
158-171
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Single Enantiomer of YK-4-279 Demonstrates Specificity in Targeting the Oncogene EWS-FLI1

Single Enantiomer of YK-4-279 Demonstrates Specificity in Targeting the Oncogene EWS-FLI1

https://doi.org/10.18632/oncotarget.454

Julie S. Barber-Rotenberg, Saravana P. Selvanathan, Yali Kong, Hayriye V. Erkizan, Tara M. Snyder, S. Peter Hong, Christina L. Kobs, Natalie L. South, Steven Summer, Philip J. Monroe, Maksymilian Chruszcz, Veselin Dobrev, Perrer N. Tosso, Lauren J. Scher, Wladek Minor, Milton L. Brown, Steven J. Metallo, Aykut Üren,  and Jeffrey A. Toretsky
172-182
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Inhibition of p53 expression modifies the specificity of chromatin binding by the androgen receptor

Inhibition of p53 expression modifies the specificity of chromatin binding by the androgen receptor

https://doi.org/10.18632/oncotarget.449

Natalya V. Guseva, Oskar W. Rokhlin, Thomas B. Bair, Rebecca B. Glover,  and Michael B. Cohen
183-194
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Research Perspectives

MiR-181b: new perspective to evaluate disease progression in chronic lymphocytic leukemia

MiR-181b: new perspective to evaluate disease progression in chronic lymphocytic leukemia

https://doi.org/10.18632/oncotarget.448

Carlo Maria Croce, Rosa Visone, Angelo Veronese,  and Veronica Balatti
195-202
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Novel targeted therapies for mantle cell lymphoma

Novel targeted therapies for mantle cell lymphoma

https://doi.org/10.18632/oncotarget.426

Lapo Alinari, Beth Christian,  and Robert Baiocchi
203-211
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Methodological Reports

A Gene Expression Profile Test for the Differential Diagnosis of Ovarian Versus Endometrial Cancers

A Gene Expression Profile Test for the Differential Diagnosis of Ovarian Versus Endometrial Cancers

https://doi.org/10.18632/oncotarget.450

Anita Lal, Rebecca Panos, Mira Marjanovic, Michael Walker, Eloisa Fuentes, Daniel S. Kapp, W David Henner, Ljubomir J. Buturovic,  and Meredith Halks-Miller
212-223
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