- Editorial Comments
- Special Feature: Editorial
- Reviews
- Brief Reports
- Research Papers
- Research Perspectives
About The Cover
Geminin localization in HME cells. Geminin localization in HME cells. Shown is the localization of geminin (green) and γ-tubulin (red) during in cytokinesis. See Blanchard et al.
Table of Contents
Editorial Comments
| Galectin-1 as an oncotarget in gliomas and melanomas |
| Florence Lefranc, Véronique Mathieu, and Robert Kiss |
| 892-893 |
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| Resistance to EGFR inhibitors: Molecular determinants and the enigma of head and neck cancer |
| Luc G.T. Morris, and Timothy A. Chan |
| 894-895 |
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Special Feature: Editorial
| Mechanism of Activation of AMPK and Upregulation of OGG1 by Rapamycin in Cancer Cells |
| Samy L. Habib |
| 958-959 |
| PDF HTML |
Reviews
| Metformin: Multi-faceted protection against cancer |
| Sonia Del Barco, Alejandro Vazquez-Martin, Sílvia Cufí, Cristina Oliveras-Ferraros, Joaquim Bosch-Barrera, Jorge Joven, Begoña Martin-Castillo, and Javier A Menendez |
| 896-917 |
| Abstract PDF HTML |
| AHI-1: a novel signaling protein and potential therapeutic target in human leukemia and brain disorders |
| Sharmin Esmailzadeh, and Xiaoyan Jiang |
| 918-934 |
| Abstract PDF HTML |
| Mitotic centromere-associated kinesin (MCAK): a potential cancer drug target |
| Mourad Sanhaji, Claire T Friel, Linda Wordeman, Frank Louwen, and Juping Yuan |
| 935-947 |
| Abstract PDF HTML |
| Regulation of glucose metabolism by p53: Emerging new roles for the tumor suppressor |
| Esha Madan, Rajan Gogna, Madan Bhatt, Uttam Pati, Periannan Kuppusamy, and Abbas Ali Mahdi |
| 948-957 |
| Abstract PDF HTML |
Brief Reports
| Pilot study of a pediatric metronomic 4-drug regimen |
| Nicolas André, Sylvie Abed, Daniel Orbach, Corinne Armari Alla, Laetitia Padovani, Eddy Pasquier, Jean Claude Gentet, and Arnauld Verschuur |
| 960-965 |
| Abstract PDF HTML |
| MED12 exon 2 mutations are common in uterine leiomyomas from South African patients |
| Netta Mäkinen, Hanna-Riikka Heinonen, Shane Moore, Ian Tomlinson, Zephne van der Spuy, and Lauri Aaltonen |
| 966-969 |
| Abstract PDF HTML |
| CRIP1 expression is correlated with a favorable outcome and less metastases in osteosarcoma patients |
| Daniel Baumhoer, Mareike Elsner, Jan Smida, Stephanie Zillmer, Sandra Rauser, Cédrik Schoene, Benjamin Balluff, Stefan Bielack, Gernot Jundt, Axel Walch, and Michaela Nathrath |
| 970-975 |
| Abstract PDF HTML |
| Frizzled receptor 6 marks rare, highly tumourigenic stem-like cells in mouse and human neuroblastomas. |
| Sandra Cantilena, Fabio Pastorino, Olesya Chayka, Annalisa Pezzolo, Vito Pistoia, Mirco Ponzoni, and Arturo Sala |
| 976-983 |
| Abstract PDF HTML Supplementary Files |
Research Papers
| PARP inhibition sensitizes childhood high grade glioma, medulloblastoma and ependymoma to radiation |
| Dannis Gilbert Van Vuurden, Esther Hulleman, Olga L.M. Meijer, Laurine E. Wedekind, Marcel Kool, Hendrik Witt, W. Peter Vandertop, Thomas Würdinger, David P. Noske, Gertjan J.L. Kaspers, and Jacqueline Cloos |
| 984-996 |
| Abstract PDF HTML |
| Antitumoral activity of allosteric inhibitors of Protein kinase CK2 |
| Virginie Moucadel, Renaud Prudent, Céline F. Sautel, Florence Teillet, Caroline Barette, Laurence Lafanechere, Veronique Receveur-Brechot, and Claude Cochet |
| 997-1010 |
| Abstract PDF HTML Supplementary Files |
| Geminin overexpression induces mammary tumors via suppressing cytokinesis. |
| Zannel Blanchard, Rohit Malik, Nicole Mullins, Christine Maric, Hugh Luk, David Horio, Brenda Hernandez, Jeffrey Killeen, and Wael M. ElShamy |
| 1011-1027 |
| Abstract PDF HTML Supplementary Files |
| Cord blood stem cells revert glioma stem cell EMT by down regulating transcriptional activation of Sox2 and Twist1 |
| Kiran Kumar Velpula, Venkata Ramesh Dasari, Andrew J. Tsung, Dzung H. Dinh, and Jasti S. Rao |
| 1028-1042 |
| Abstract PDF HTML Supplementary Files |
| Putting the brakes on mammary tumorigenesis: Loss of STAT1 predisposes to intraepithelial neoplasias |
| Christine Schneckenleithner, Zsuzsanna Bago-Horvath, Helmuth Dolznig, Nina Neugebauer, Karoline Kollmann, Thomas Kolbe, Thomas Decker, Dontscho Kerjaschki, Kay-Uwe Wagner, Mathias Müller, Dagmar Stoiber, and Veronika Sexl |
| 1043-1054 |
| Abstract PDF HTML Supplementary Files |
| A Novel Dual Signaling Axis for NSP 5a3a induced apoptosis in Head and Neck Carcinoma |
| Luca D'Agostino, and Antonio Giordano |
| 1055-1074 |
| Abstract PDF HTML |
| Annexin A2 is a novel Cellular Redox Regulatory Protein involved in Tumorigenesis |
| Patricia Alexandra Madureira, Richard Hill, Victoria Ann Miller, Carman Giacomantonio, Patrick WK Lee, and David Morton Waisman |
| 1075-1093 |
| Abstract PDF HTML Supplementary Files |
| DNA-PKCS binding to p53 on the p21WAF1/CIP1 promoter blocks transcription resulting in cell death |
| Richard Hill, Patricia A. Madureira, David M Waisman, and Patrick W.K. Lee |
| 1094-1108 |
| Abstract PDF HTML Supplementary Files |
| Thyrocyte-specific inactivation of p53 and Pten results in anaplastic thyroid carcinomas faithfully recapitulating human tumors |
| Valeria G. Antico Arciuch, Marika A. Russo, Mariavittoria Dima, Kristy S. Kang, Florence Dasrath, Xiao-Hui Liao, Samuel Refetoff, Cristina Montagna, and Antonio Di Cristofano |
| 1109-1126 |
| Abstract PDF HTML |
| Germline mutations in the oncogene EZH2 cause Weaver syndrome and increased human height |
| Katrina Tatton-Brown, Sandra Hanks, Elise Ruark, Anna Zachariou, Silvana Del Vecchio Duarte, Emma Ramsay, Katie Snape, Anne Murray, Elizabeth R. Perdeaux, Sheila Seal, Chey Loveday, Siddharth Banka, Carol Clericuzio, Frances Flinter, Alex Magee, Vivienne McConnell, Michael Patton, Wolfgang Raith, Julia Rankin, Miranda Splitt, Volker Strenger, Clare Taylor, Patricia Wheeler, I. Karen Temple, Trevor Cole, Jenny Douglas, and Nazneen Rahman |
| 1127-1133 |
| Abstract PDF HTML Supplementary Files |
| PIM kinase isoform specific regulation of MIG6 expression and EGFR signaling in prostate cancer cells |
| Allan Siu, Carl Virtanen, and Jan Jongstra |
| 1134-1144 |
| Abstract PDF HTML Supplementary Files |
| TAp73alpha protects small cell lung carcinoma cells from caspase-2 induced mitochondrial mediated apoptotic cell death |
| Naveen Muppani, Ulrika Nyman, and Bertrand Joseph |
| 1145-1154 |
| Abstract PDF HTML |
| Phosphatase inhibitor, sodium stibogluconate, in combination with interferon (IFN) alpha 2b: phase I trials to identify pharmacodynamic and clinical effects |
| Taolin Yi, Paul Elson, Masato Mitsuhashi, Barbara Jacobs, Emese Hollovary, G. Thomas Budd, Timothy Spiro, Pierre Triozzi, and Ernest Borden |
| 1155-1164 |
| Abstract PDF HTML Supplementary Files |
| Overexpression of TWIST2 correlates with poor prognosis in Head and Neck Squamous Cell Carcinomas |
| Daniela Gasparotto, Jerry Polesel, Alessandra Marzotto, Roberta Colladel, Sara Piccinin, Piergiorgio Modena, Alessandra Grizzo, Sandro Sulfaro, Diego Serraino, Luigi Barzan, Claudio Doglioni, and Roberta Maestro |
| 1165-1175 |
| Abstract PDF HTML Supplementary Files |
| Phospholipase PLA2G7, associated with aggressive prostate cancer, promotes prostate cancer cell migration and invasion and is inhibited by statins |
| Paula Vainio, Laura Lehtinen, Tuomas Mirtti, Mika Hilvo, Tuulikki Seppänen-Laakso, Johannes Virtanen, Anna Sankila, Stig Nordling, Johan Lundin, Antti Rannikko, Matej Orešič, Olli Kallioniemi, and Kristiina Iljin |
| 1176-1190 |
| Abstract PDF HTML Supplementary Files |
| Genome-wide analysis discloses reversal of the hypoxia-induced changes of gene expression in colon cancer cells by zinc supplementation |
| Michal Sheffer, Amos J. Simon, Jasmine Jacob-Hirsch, Gideon Rechavi, Eytan Domany, David Givol, and Gabriella D'Orazi |
| 1191-1202 |
| Abstract PDF HTML Supplementary Files |
| Mutant p53 uses p63 as a molecular chaperone to alter gene expression and induce a pro-invasive secretome |
| Paul M. Neilsen, Jacqueline E. Noll, Rachel J. Suetani, Renee B Schulz, Fares Al-Ejeh, Andreas Evdokiou, David P. Lane, and David F. Callen |
| 1203-1217 |
| Abstract PDF HTML Supplementary Files |
| The suppression of FOXM1 and its targets in breast cancer xenograft tumors by siRNA |
| Ming Wang, and Andrei L. Gartel |
| 1218-1226 |
| Abstract PDF HTML |
| Characterization of the Human Folate Receptor Alpha Via Novel Antibody-Based Probes |
| Daniel J. O’Shannessy, Elizabeth B. Somers, Earl Albone, Xin Cheng, Young Chul Park, Brian E. Tomkowicz, Yoshitomo Hamuro, Thomas O. Kohl, Tracy M. Forsyth, Robert Smale, Yao-Shi Fu, and Nicholas C. Nicolaides |
| 1227-1243 |
| Abstract PDF HTML |
| A Modular Strategy to Prepare Multivalent Inhibitors of Prostate-Specific Membrane Antigen (PSMA) |
| Sangeeta Ray Banerjee, Mrudula Pullambhatla, Hassan Shallal, Ala Lisok, Ronnie C. Mease, and Martin G. Pomper |
| 1244-1253 |
| Abstract PDF HTML |
| Pooled shRNA screen for sensitizers to inhibition of the mitotic regulator polo-like kinase (PLK1) |
| Nancy Liu-Sullivan, Jianping Zhang, Amy Bakleh, John Marchica, Jinyu Li, Despina Siolas, Sylvie Laquerre, Yan Y. Degenhardt, Richard Wooster, Kenneth Chang, Gregory J. Hannon, and Scott Powers |
| 1254-1264 |
| Abstract PDF HTML |
| Identification of a chrXq27.3 microRNA cluster associated with early relapse in advanced stage ovarian cancer patients |
| Marina Bagnoli, Loris De Cecco, Anna Granata, Roberta Nicoletti, Edoardo Marchesi, Paola Alberti, Barbara Valeri, Massimo Libra, Mattia Barbareschi, Francesco Raspagliesi, Delia Mezzanzanica, and Silvana Canevari |
| 1265-1278 |
| Abstract PDF HTML Supplementary Files |
| Selenium is a modulator of circadian clock that protects mice from the toxicity of a chemotherapeutic drug via upregulation of the core clock protein, BMAL1 |
| Yan Hu, Mary L. Spengler, Karen K. Kuropatwinski, Maria Comas, Marilyn Jackson, Mikhail V. Chernov, Anatoly S. Gleiberman, Natalia Fedtsova, Youcef M. Rustum, Andrei V. Gudkov, and Marina Antoch |
| 1279-1290 |
| Abstract PDF HTML Supplementary Files |
| Epigenetic regulation of Delta-Like1 controls Notch1 activation in gastric cancer |
| Giulia Piazzi, Lucia Fini, Michael Selgrad, Melissa Garcia, Yahya Daoud, Thomas Wex, Peter Malfertheiner, Antonio Gasbarrini, Marco Romano, Richard L. Meyer, Robert M Genta, James G. Fox, C. Richard Boland, Franco Bazzoli, and Luigi Ricciardiello |
| 1291-1301 |
| Abstract PDF HTML |
Research Perspectives
| Targeting Autophagy Addiction in Cancer |
| Joseph D. Mancias, and Alec C. Kimmelman |
| 1302-1306 |
| Abstract PDF HTML |
| Finding cancer’s weakest link |
| Nicole Michel Sodir, and Gerard I. Evan |
| 1307-1313 |
| Abstract PDF HTML |
| Will PI3K pathway inhibitors be effective as single agents in patients with cancer? |
| Joan T. Garrett, Anindita Chakrabarty, and Carlos L. Arteaga |
| 1314-1319 |
| Abstract PDF HTML |
| AMPK in BCR-ABL expressing leukemias. Regulatory effects and therapeutic implications. |
| Leonidas Platanias, and Eliza Vakana |
| 1322-1328 |
| Abstract PDF HTML |
| Is human cytomegalovirus a target in cancer therapy? |
| John Inge Johnsen, Ninib Baryawno, and Cecilia Söderberg-Nauclér |
| 1329-1338 |
| Abstract PDF HTML |
| T cell- but not tumor cell-produced TGF-β1 promotes the development of spontaneous mammary cancer |
| Abira Sarkar, Moses K. Donkor, and Ming O. Li |
| 1339-1351 |
| Abstract PDF HTML |
| NCI’s provocative questions on cancer: some answers to ignite discussion |
| Mikhail V. Blagosklonny |
| 1352-1367 |
| Abstract PDF HTML |
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