Oncotarget

Vol 2, No 12

December 2011

View Archive »

Order a Reprint

About The Cover

Geminin localization in HME cells. Geminin localization in HME cells. Shown is the localization of geminin (green) and γ-tubulin (red) during in cytokinesis. See Blanchard et al.

Table of Contents

Editorial Comments

Galectin-1 as an oncotarget in gliomas and melanomas

Galectin-1 as an oncotarget in gliomas and melanomas

https://doi.org/10.18632/oncotarget.408

Florence Lefranc, Véronique Mathieu,  and Robert Kiss
892-893
PDF  |  HTML  |  Order a Reprint

Resistance to EGFR inhibitors: Molecular determinants and the enigma of head and neck cancer

Resistance to EGFR inhibitors: Molecular determinants and the enigma of head and neck cancer

https://doi.org/10.18632/oncotarget.407

Luc G.T. Morris,  and Timothy A. Chan
894-895
PDF  |  HTML  |  Order a Reprint

Reviews

Metformin: Multi-faceted protection against cancer

Metformin: Multi-faceted protection against cancer

https://doi.org/10.18632/oncotarget.387

Sonia Del Barco, Alejandro Vazquez-Martin, Sílvia Cufí, Cristina Oliveras-Ferraros, Joaquim Bosch-Barrera, Jorge Joven, Begoña Martin-Castillo,  and Javier A Menendez
896-917
Abstract  |  PDF  |  HTML  |  Order a Reprint

AHI-1: a novel signaling protein and potential therapeutic target in human leukemia and brain disorders

AHI-1: a novel signaling protein and potential therapeutic target in human leukemia and brain disorders

https://doi.org/10.18632/oncotarget.405

Sharmin Esmailzadeh,  and Xiaoyan Jiang
918-934
Abstract  |  PDF  |  HTML  |  Order a Reprint

Mitotic centromere-associated kinesin (MCAK): a potential cancer drug target

Mitotic centromere-associated kinesin (MCAK): a potential cancer drug target

https://doi.org/10.18632/oncotarget.416

Mourad Sanhaji, Claire T Friel, Linda Wordeman, Frank Louwen,  and Juping Yuan
935-947
Abstract  |  PDF  |  HTML  |  Order a Reprint

Regulation of glucose metabolism by p53: Emerging new roles for the tumor suppressor

Regulation of glucose metabolism by p53: Emerging new roles for the tumor suppressor

https://doi.org/10.18632/oncotarget.389

Esha Madan, Rajan Gogna, Madan Bhatt, Uttam Pati, Periannan Kuppusamy,  and Abbas Ali Mahdi
948-957
Abstract  |  PDF  |  HTML  |  Order a Reprint

Special Feature: Editorial

Mechanism of Activation of AMPK and Upregulation of OGG1 by Rapamycin in Cancer Cells

Mechanism of Activation of AMPK and Upregulation of OGG1 by Rapamycin in Cancer Cells

https://doi.org/10.18632/oncotarget.381

Samy L. Habib
958-959
Abstract  |  PDF  |  HTML  |  Order a Reprint

Brief Reports

Pilot study of a pediatric metronomic 4-drug regimen

Pilot study of a pediatric metronomic 4-drug regimen

https://doi.org/10.18632/oncotarget.358

Nicolas André, Sylvie Abed, Daniel Orbach, Corinne Armari Alla, Laetitia Padovani, Eddy Pasquier, Jean Claude Gentet,  and Arnauld Verschuur
960-965
Abstract  |  PDF  |  HTML  |  Order a Reprint

MED12 exon 2 mutations are common in uterine leiomyomas from South African patients

MED12 exon 2 mutations are common in uterine leiomyomas from South African patients

https://doi.org/10.18632/oncotarget.370

Netta Mäkinen, Hanna-Riikka Heinonen, Shane Moore, Ian Tomlinson, Zephne van der Spuy,  and Lauri Aaltonen
966-969
Abstract  |  PDF  |  HTML  |  Order a Reprint

CRIP1 expression is correlated with a favorable outcome and less metastases in osteosarcoma patients

CRIP1 expression is correlated with a favorable outcome and less metastases in osteosarcoma patients

https://doi.org/10.18632/oncotarget.398

Daniel Baumhoer, Mareike Elsner, Jan Smida, Stephanie Zillmer, Sandra Rauser, Cédrik Schoene, Benjamin Balluff, Stefan Bielack, Gernot Jundt, Axel Walch,  and Michaela Nathrath
970-975
Abstract  |  PDF  |  HTML  |  Order a Reprint

Frizzled receptor 6 marks rare, highly tumourigenic stem-like cells in mouse and human neuroblastomas.

Frizzled receptor 6 marks rare, highly tumourigenic stem-like cells in mouse and human neuroblastomas.

https://doi.org/10.18632/oncotarget.410

Sandra Cantilena, Fabio Pastorino, Olesya Chayka, Annalisa Pezzolo, Vito Pistoia, Mirco Ponzoni,  and Arturo Sala
976-983
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Research Papers

PARP inhibition sensitizes childhood high grade glioma, medulloblastoma and ependymoma to radiation

PARP inhibition sensitizes childhood high grade glioma, medulloblastoma and ependymoma to radiation

https://doi.org/10.18632/oncotarget.362

Dannis Gilbert Van Vuurden, Esther Hulleman, Olga L.M. Meijer, Laurine E. Wedekind, Marcel Kool, Hendrik Witt, W. Peter Vandertop, Thomas Würdinger, David P. Noske, Gertjan J.L. Kaspers,  and Jacqueline Cloos
984-996
Abstract  |  PDF  |  HTML  |  Order a Reprint

Antitumoral activity of allosteric inhibitors of Protein kinase CK2

Antitumoral activity of allosteric inhibitors of Protein kinase CK2

https://doi.org/10.18632/oncotarget.361

Virginie Moucadel, Renaud Prudent, Céline F. Sautel, Florence Teillet, Caroline Barette, Laurence Lafanechere, Veronique Receveur-Brechot,  and Claude Cochet
997-1010
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Geminin overexpression induces mammary tumors via suppressing cytokinesis.

Geminin overexpression induces mammary tumors via suppressing cytokinesis.

https://doi.org/10.18632/oncotarget.363

Zannel Blanchard, Rohit Malik, Nicole Mullins, Christine Maric, Hugh Luk, David Horio, Brenda Hernandez, Jeffrey Killeen,  and Wael M. ElShamy
1011-1027
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Cord blood stem cells revert glioma stem cell EMT by down regulating transcriptional activation of Sox2 and Twist1

Cord blood stem cells revert glioma stem cell EMT by down regulating transcriptional activation of Sox2 and Twist1

https://doi.org/10.18632/oncotarget.367

Kiran Kumar Velpula, Venkata Ramesh Dasari, Andrew J. Tsung, Dzung H. Dinh,  and Jasti S. Rao
1028-1042
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Putting the brakes on mammary tumorigenesis: Loss of STAT1 predisposes to intraepithelial neoplasias

Putting the brakes on mammary tumorigenesis: Loss of STAT1 predisposes to intraepithelial neoplasias

https://doi.org/10.18632/oncotarget.371

Christine Schneckenleithner, Zsuzsanna Bago-Horvath, Helmuth Dolznig, Nina Neugebauer, Karoline Kollmann, Thomas Kolbe, Thomas Decker, Dontscho Kerjaschki, Kay-Uwe Wagner, Mathias Müller, Dagmar Stoiber,  and Veronika Sexl
1043-1054
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A Novel Dual Signaling Axis for NSP 5a3a induced apoptosis in Head and Neck Carcinoma

A Novel Dual Signaling Axis for NSP 5a3a induced apoptosis in Head and Neck Carcinoma

https://doi.org/10.18632/oncotarget.306

Luca D'Agostino,  and Antonio Giordano
1055-1074
Abstract  |  PDF  |  HTML  |  Order a Reprint

Annexin A2 is a novel Cellular Redox Regulatory Protein involved in Tumorigenesis

Annexin A2 is a novel Cellular Redox Regulatory Protein involved in Tumorigenesis

https://doi.org/10.18632/oncotarget.375

Patricia Alexandra Madureira, Richard Hill, Victoria Ann Miller, Carman Giacomantonio, Patrick WK Lee,  and David Morton Waisman
1075-1093
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

DNA-PKCS binding to p53 on the p21WAF1/CIP1 promoter blocks transcription resulting in cell death

DNA-PKCS binding to p53 on the p21WAF1/CIP1 promoter blocks transcription resulting in cell death

https://doi.org/10.18632/oncotarget.378

Richard Hill, Patricia A. Madureira, David M Waisman,  and Patrick W.K. Lee
1094-1108
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Thyrocyte-specific inactivation of p53 and Pten results in anaplastic thyroid carcinomas faithfully recapitulating human tumors

Thyrocyte-specific inactivation of p53 and Pten results in anaplastic thyroid carcinomas faithfully recapitulating human tumors

https://doi.org/10.18632/oncotarget.380

Valeria G. Antico Arciuch, Marika A. Russo, Mariavittoria Dima, Kristy S. Kang, Florence Dasrath, Xiao-Hui Liao, Samuel Refetoff, Cristina Montagna,  and Antonio Di Cristofano
1109-1126
Abstract  |  PDF  |  HTML  |  Order a Reprint

Germline mutations in the oncogene EZH2 cause Weaver syndrome and increased human height

Germline mutations in the oncogene EZH2 cause Weaver syndrome and increased human height

https://doi.org/10.18632/oncotarget.385

Katrina Tatton-Brown, Sandra Hanks, Elise Ruark, Anna Zachariou, Silvana Del Vecchio Duarte, Emma Ramsay, Katie Snape, Anne Murray, Elizabeth R. Perdeaux, Sheila Seal, Chey Loveday, Siddharth Banka, Carol Clericuzio, Frances Flinter, Alex Magee, Vivienne McConnell, Michael Patton, Wolfgang Raith, Julia Rankin, Miranda Splitt, Volker Strenger, Clare Taylor, Patricia Wheeler, I. Karen Temple, Trevor Cole, Jenny Douglas,  and Nazneen Rahman
1127-1133
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

PIM kinase isoform specific regulation of MIG6 expression and EGFR signaling in prostate cancer cells

PIM kinase isoform specific regulation of MIG6 expression and EGFR signaling in prostate cancer cells

https://doi.org/10.18632/oncotarget.386

Allan Siu, Carl Virtanen,  and Jan Jongstra
1134-1144
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

TAp73alpha protects small cell lung carcinoma cells from caspase-2 induced mitochondrial mediated apoptotic cell death

TAp73alpha protects small cell lung carcinoma cells from caspase-2 induced mitochondrial mediated apoptotic cell death

https://doi.org/10.18632/oncotarget.391

Naveen Muppani, Ulrika Nyman,  and Bertrand Joseph
1145-1154
Abstract  |  PDF  |  HTML  |  Order a Reprint

Phosphatase inhibitor, sodium stibogluconate, in combination with interferon (IFN) alpha 2b: phase I trials to identify pharmacodynamic and clinical effects

Phosphatase inhibitor, sodium stibogluconate, in combination with interferon (IFN) alpha 2b: phase I trials to identify pharmacodynamic and clinical effects

https://doi.org/10.18632/oncotarget.563

Taolin Yi, Paul Elson, Masato Mitsuhashi, Barbara Jacobs, Emese Hollovary, G. Thomas Budd, Timothy Spiro, Pierre Triozzi,  and Ernest Borden
1155-1164
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Overexpression of TWIST2 correlates with poor prognosis in Head and Neck Squamous Cell Carcinomas

Overexpression of TWIST2 correlates with poor prognosis in Head and Neck Squamous Cell Carcinomas

https://doi.org/10.18632/oncotarget.390

Daniela Gasparotto, Jerry Polesel, Alessandra Marzotto, Roberta Colladel, Sara Piccinin, Piergiorgio Modena, Alessandra Grizzo, Sandro Sulfaro, Diego Serraino, Luigi Barzan, Claudio Doglioni,  and Roberta Maestro
1165-1175
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Phospholipase PLA2G7, associated with aggressive prostate cancer, promotes prostate cancer cell migration and invasion and is inhibited by statins

Phospholipase PLA2G7, associated with aggressive prostate cancer, promotes prostate cancer cell migration and invasion and is inhibited by statins

https://doi.org/10.18632/oncotarget.397

Paula Vainio, Laura Lehtinen, Tuomas Mirtti, Mika Hilvo, Tuulikki Seppänen-Laakso, Johannes Virtanen, Anna Sankila, Stig Nordling, Johan Lundin, Antti Rannikko, Matej Orešič, Olli Kallioniemi,  and Kristiina Iljin
1176-1190
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Genome-wide analysis discloses reversal of the hypoxia-induced changes of gene expression in colon cancer cells by zinc supplementation

Genome-wide analysis discloses reversal of the hypoxia-induced changes of gene expression in colon cancer cells by zinc supplementation

https://doi.org/10.18632/oncotarget.395

Michal Sheffer, Amos J. Simon, Jasmine Jacob-Hirsch, Gideon Rechavi, Eytan Domany, David Givol,  and Gabriella D'Orazi
1191-1202
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Mutant p53 uses p63 as a molecular chaperone to alter gene expression and induce a pro-invasive secretome

Mutant p53 uses p63 as a molecular chaperone to alter gene expression and induce a pro-invasive secretome

https://doi.org/10.18632/oncotarget.382

Paul M. Neilsen, Jacqueline E. Noll, Rachel J. Suetani, Renee B Schulz, Fares Al-Ejeh, Andreas Evdokiou, David P. Lane,  and David F. Callen
1203-1217
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The suppression of FOXM1 and its targets in breast cancer xenograft tumors by siRNA

The suppression of FOXM1 and its targets in breast cancer xenograft tumors by siRNA

https://doi.org/10.18632/oncotarget.359

Ming Wang,  and Andrei L. Gartel
1218-1226
Abstract  |  PDF  |  HTML  |  Order a Reprint

Characterization of the Human Folate Receptor Alpha Via Novel Antibody-Based Probes

Characterization of the Human Folate Receptor Alpha Via Novel Antibody-Based Probes

https://doi.org/10.18632/oncotarget.412

Daniel J. O’Shannessy, Elizabeth B. Somers, Earl Albone, Xin Cheng, Young Chul Park, Brian E. Tomkowicz, Yoshitomo Hamuro, Thomas O. Kohl, Tracy M. Forsyth, Robert Smale, Yao-Shi Fu,  and Nicholas C. Nicolaides
1227-1243
Abstract  |  PDF  |  HTML  |  Order a Reprint

A Modular Strategy to Prepare Multivalent Inhibitors of Prostate-Specific Membrane Antigen (PSMA)

A Modular Strategy to Prepare Multivalent Inhibitors of Prostate-Specific Membrane Antigen (PSMA)

https://doi.org/10.18632/oncotarget.415

Sangeeta Ray Banerjee, Mrudula Pullambhatla, Hassan Shallal, Ala Lisok, Ronnie C. Mease,  and Martin G. Pomper
1244-1253
Abstract  |  PDF  |  HTML  |  Order a Reprint

Pooled shRNA screen for sensitizers to inhibition of the mitotic regulator polo-like kinase (PLK1)

Pooled shRNA screen for sensitizers to inhibition of the mitotic regulator polo-like kinase (PLK1)

https://doi.org/10.18632/oncotarget.406

Nancy Liu-Sullivan, Jianping Zhang, Amy Bakleh, John Marchica, Jinyu Li, Despina Siolas, Sylvie Laquerre, Yan Y. Degenhardt, Richard Wooster, Kenneth Chang, Gregory J. Hannon,  and Scott Powers
1254-1264
Abstract  |  PDF  |  HTML  |  Order a Reprint

Identification of a chrXq27.3 microRNA cluster associated with early relapse in advanced stage ovarian cancer patients

Identification of a chrXq27.3 microRNA cluster associated with early relapse in advanced stage ovarian cancer patients

https://doi.org/10.18632/oncotarget.401

Marina Bagnoli, Loris De Cecco, Anna Granata, Roberta Nicoletti, Edoardo Marchesi, Paola Alberti, Barbara Valeri, Massimo Libra, Mattia Barbareschi, Francesco Raspagliesi, Delia Mezzanzanica,  and Silvana Canevari
1265-1278
Abstract  |  PDF  |  Addendum  |  HTML  |  Supplementary Information  |  Order a Reprint

Selenium is a modulator of circadian clock that protects mice from the toxicity of a chemotherapeutic drug via upregulation of the core clock protein, BMAL1

Selenium is a modulator of circadian clock that protects mice from the toxicity of a chemotherapeutic drug via upregulation of the core clock protein, BMAL1

https://doi.org/10.18632/oncotarget.411

Yan Hu, Mary L. Spengler, Karen K. Kuropatwinski, Maria Comas, Marilyn Jackson, Mikhail V. Chernov, Anatoly S. Gleiberman, Natalia Fedtsova, Youcef M. Rustum, Andrei V. Gudkov,  and Marina Antoch
1279-1290
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Epigenetic regulation of Delta-Like1 controls Notch1 activation in gastric cancer

Epigenetic regulation of Delta-Like1 controls Notch1 activation in gastric cancer

https://doi.org/10.18632/oncotarget.414

Giulia Piazzi, Lucia Fini, Michael Selgrad, Melissa Garcia, Yahya Daoud, Thomas Wex, Peter Malfertheiner, Antonio Gasbarrini, Marco Romano, Richard L. Meyer, Robert M Genta, James G. Fox, C. Richard Boland, Franco Bazzoli,  and Luigi Ricciardiello
1291-1301
Abstract  |  PDF  |  HTML  |  Order a Reprint

Research Perspectives

Targeting Autophagy Addiction in Cancer

Targeting Autophagy Addiction in Cancer

https://doi.org/10.18632/oncotarget.384

Joseph D. Mancias,  and Alec C. Kimmelman
1302-1306
Abstract  |  PDF  |  HTML  |  Order a Reprint

Finding cancer’s weakest link

Finding cancer’s weakest link

https://doi.org/10.18632/oncotarget.396

Nicole Michel Sodir,  and Gerard I. Evan
1307-1313
Abstract  |  PDF  |  HTML  |  Order a Reprint

Will PI3K pathway inhibitors be effective as single agents in patients with cancer?

Will PI3K pathway inhibitors be effective as single agents in patients with cancer?

https://doi.org/10.18632/oncotarget.409

Joan T. Garrett, Anindita Chakrabarty,  and Carlos L. Arteaga
1314-1319
Abstract  |  PDF  |  HTML  |  Order a Reprint

AMPK in BCR-ABL expressing leukemias. Regulatory effects and therapeutic implications.

AMPK in BCR-ABL expressing leukemias. Regulatory effects and therapeutic implications.

https://doi.org/10.18632/oncotarget.413

Leonidas Platanias,  and Eliza Vakana
1322-1328
Abstract  |  PDF  |  HTML  |  Order a Reprint

Is human cytomegalovirus a target in cancer therapy?

Is human cytomegalovirus a target in cancer therapy?

https://doi.org/10.18632/oncotarget.383

John Inge Johnsen, Ninib Baryawno,  and Cecilia Söderberg-Nauclér
1329-1338
Abstract  |  PDF  |  HTML  |  Order a Reprint

T cell- but not tumor cell-produced TGF-β1 promotes the development of spontaneous mammary cancer

T cell- but not tumor cell-produced TGF-β1 promotes the development of spontaneous mammary cancer

https://doi.org/10.18632/oncotarget.403

Abira Sarkar, Moses K. Donkor,  and Ming O. Li
1339-1351
Abstract  |  PDF  |  HTML  |  Order a Reprint

NCI’s provocative questions on cancer: some answers to ignite discussion

NCI’s provocative questions on cancer: some answers to ignite discussion

https://doi.org/10.18632/oncotarget.432

Mikhail V. Blagosklonny
1352-1367
Abstract  |  PDF  |  HTML  |  Order a Reprint


Copyright © 2017 Impact Journals
Impact Journals is a registered trademark of Impact Journals, LLC