Oncotarget

Vol 8, No 34

August 22, 2017

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About The Cover

The cover for issue 34 of Oncotarget features Figure 3C, "SMYD2-mediated β-catenin methylation is required for expression of Wnt downstream genes and β-catenin nuclear translocation by FOXM1," from Deng, et al.

Table of Contents

News

Fledglings in p53 signaling network

Fledglings in p53 signaling network

https://doi.org/10.18632/oncotarget.19229

Takashi Tokino, Masashi Idogawa,  and Yasushi Sasaki
55768-55769
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Editorial

PRRT2, a network stability gene

PRRT2, a network stability gene

https://doi.org/10.18632/oncotarget.19506

Caterina Michetti, Anna Corradi,  and Fabio Benfenati
55770-55771
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Transglutaminase in neurological disease

Transglutaminase in neurological disease

https://doi.org/10.18632/oncotarget.19694

Guylaine Hoffner,  and Philippe Djian
55772-55773
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Cancer’s new Achilles’ heel?

Cancer’s new Achilles’ heel?

https://doi.org/10.18632/oncotarget.19954

Gareth I. Owen
55774-55775
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Priority Research Papers

Dicer suppresses cytoskeleton remodeling and tumorigenesis of colorectal epithelium by miR-324-5p mediated suppression of HMGXB3 and WASF-2

Dicer suppresses cytoskeleton remodeling and tumorigenesis of colorectal epithelium by miR-324-5p mediated suppression of HMGXB3 and WASF-2

https://doi.org/10.18632/oncotarget.18218

Li Na Sun, Cheng Xing, Zheng Zhi, Yao Liu, Liang-Yan Chen, Tong Shen, Qun Zhou, Yu Hong Liu, Wen Juan Gan, Jing-Ru Wang, Yong Xu,  and Jian Ming Li
55776-55789
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Identification of a novel p53 target, COL17A1, that inhibits breast cancer cell migration and invasion

Identification of a novel p53 target, COL17A1, that inhibits breast cancer cell migration and invasion

https://doi.org/10.18632/oncotarget.18433

Varalee Yodsurang, Chizu Tanikawa, Takafumi Miyamoto, Paulisally Hau Yi Lo, Makoto Hirata,  and Koichi Matsuda
55790-55803
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Resistance to CTLA-4 checkpoint inhibition reversed through selective elimination of granulocytic myeloid cells

Resistance to CTLA-4 checkpoint inhibition reversed through selective elimination of granulocytic myeloid cells

https://doi.org/10.18632/oncotarget.18437

Paul E. Clavijo, Ellen C. Moore, Jianhong Chen, Ruth J. Davis, Jay Friedman, Young Kim, Carter Van Waes, Zhong Chen,  and Clint T. Allen
55804-55820
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Identification of a p53-repressed gene module in breast cancer cells

Identification of a p53-repressed gene module in breast cancer cells

https://doi.org/10.18632/oncotarget.19608

Takafumi Miyamoto, Chizu Tanikawa, Varalee Yodsurang, Yao-Zhong Zhang, Seiya Imoto, Rui Yamaguchi, Satoru Miyano, Hidewaki Nakagawa,  and Koichi Matsuda
55821-55836
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Critical roles of SMYD2-mediated β-catenin methylation for nuclear translocation and activation of Wnt signaling

Critical roles of SMYD2-mediated β-catenin methylation for nuclear translocation and activation of Wnt signaling

https://doi.org/10.18632/oncotarget.19646

Xiaolan Deng, Ryuji Hamamoto, Theodore Vougiouklakis, Rui Wang, Yuichiro Yoshioka, Takehiro Suzuki, Naoshi Dohmae, Yo Matsuo, Jae-Hyun Park,  and Yusuke Nakamura
55837-55847
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Loss of p16INK4A stimulates aberrant mitochondrial biogenesis through a CDK4/Rb-independent pathway

Loss of p16INK4A stimulates aberrant mitochondrial biogenesis through a CDK4/Rb-independent pathway

https://doi.org/10.18632/oncotarget.19862

Ethika Tyagi, Bin Liu, Chelsea Li, Tong Liu, Jared Rutter,  and Douglas Grossman
55848-55862
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Domain analysis reveals striking functional differences between the regulatory subunits of phosphatidylinositol 3-kinase (PI3K), p85α and p85β

Domain analysis reveals striking functional differences between the regulatory subunits of phosphatidylinositol 3-kinase (PI3K), p85α and p85β

https://doi.org/10.18632/oncotarget.19866

Yoshihiro Ito, Peter K. Vogt,  and Jonathan R. Hart
55863-55876
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Priority Research Papers: Immunology

Zbtb1 controls NKp46+ ROR-gamma-T+ innate lymphoid cell (ILC3) development

Zbtb1 controls NKp46+ ROR-gamma-T+ innate lymphoid cell (ILC3) development

https://doi.org/10.18632/oncotarget.19645

Ying Lu, Xianyu Zhang, Nicolas Bouladoux, Saransh Neel Kaul, Kangxin Jin, Derek Sant’Angelo, Yasmine Belkaid,  and Damian Kovalovsky
55877-55888
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Research Papers: Gerotarget (Focus on Aging)

Pharynx mitochondrial [Ca2+] dynamics in live C. elegans worms during aging

Pharynx mitochondrial [Ca2+] dynamics in live C. elegans worms during aging

https://doi.org/10.18632/oncotarget.18600

Pilar Alvarez-Illera, Paloma García-Casas, Jessica Arias-del-Val, Rosalba I. Fonteriz, Javier Alvarez,  and Mayte Montero
55889-55900
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Differentially expressed lncRNAs and miRNAs with associated ceRNA networks in aged mice with postoperative cognitive dysfunction

Differentially expressed lncRNAs and miRNAs with associated ceRNA networks in aged mice with postoperative cognitive dysfunction

https://doi.org/10.18632/oncotarget.18362

Changwei Wei, Ting Luo, Shanshan Zou, Xiaobin Zhou, Wenzhen Shen, Xiaolin Ji, Qi Li,  and Anshi Wu
55901-55914
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Detecting the genetic link between Alzheimer’s disease and obesity using bioinformatics analysis of GWAS data

Detecting the genetic link between Alzheimer’s disease and obesity using bioinformatics analysis of GWAS data

https://doi.org/10.18632/oncotarget.19115

Qi-Shuai Zhuang, Hao Zheng, Xiao-Dan Gu, Liang Shen,  and Hong-Fang Ji
55915-55919
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Research Papers: Pathology

NiaoDuQing granules relieve chronic kidney disease symptoms by decreasing renal fibrosis and anemia

NiaoDuQing granules relieve chronic kidney disease symptoms by decreasing renal fibrosis and anemia

https://doi.org/10.18632/oncotarget.18473

Xu Wang, Suyun Yu, Qi Jia, Lichuan Chen, Jinqiu Zhong, Yanhong Pan, Peiliang Shen, Yin Shen, Siliang Wang, Zhonghong Wei, Yuzhu Cao,  and Yin Lu
55920-55937
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Classical swine fever virus Shimen infection increases p53 signaling to promote cell cycle arrest in porcine alveolar macrophages

Classical swine fever virus Shimen infection increases p53 signaling to promote cell cycle arrest in porcine alveolar macrophages

https://doi.org/10.18632/oncotarget.18997

Pengbo Ning, Congxia Hu, Xuepeng Li, Yulu Zhou, Aoxue Hu, Ya Zhang, Lifang Gao, Cunmei Gong, Kangkang Guo, Xianghan Zhang,  and Yanming Zhang
55938-55949
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PKCθ utility in diagnosing c-KIT/DOG-1 double negative gastrointestinal stromal tumors

PKCθ utility in diagnosing c-KIT/DOG-1 double negative gastrointestinal stromal tumors

https://doi.org/10.18632/oncotarget.19116

Attila Kövecsi, Ioan Jung, Zoltan Szentirmay, Tivadar Bara, Tivadar Bara Jr, Daniel Popa,  and Simona Gurzu
55950-55957
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Research Papers: Immunology

Synergistic antibiotic effect of looped antimicrobial peptide CLP-19 with bactericidal and bacteriostatic agents

Synergistic antibiotic effect of looped antimicrobial peptide CLP-19 with bactericidal and bacteriostatic agents

https://doi.org/10.18632/oncotarget.18124

Di Li, Ya Yang, Zhiqiang Tian, Jun Lv, Fengjun Sun, Qian Wang, Yao Liu,  and Peiyuan Xia
55958-55966
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Melatonin inhibits Sirt1-dependent NAMPT and NFAT5 signaling in chondrocytes to attenuate osteoarthritis

Melatonin inhibits Sirt1-dependent NAMPT and NFAT5 signaling in chondrocytes to attenuate osteoarthritis

https://doi.org/10.18632/oncotarget.18356

Jia Yi Guo, Feng Li, Yong Bing Wen, Hong Xun Cui, Ma Long Guo, Lin Zhang, Yun Fei Zhang, Yan Jin Guo,  and Yan Xing Guo
55967-55983
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Research Papers: Autophagy and Cell Death

Hyperosmotic stress stimulates autophagy via polycystin-2

Hyperosmotic stress stimulates autophagy via polycystin-2

https://doi.org/10.18632/oncotarget.18995

Daniel Peña-Oyarzun, Rodrigo Troncoso, Catalina Kretschmar, Cecilia Hernando, Mauricio Budini, Eugenia Morselli, Sergio Lavandero,  and Alfredo Criollo
55984-55997
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GABARAPL1 tumor suppressive function is independent of its conjugation to autophagosomes in MCF-7 breast cancer cells

GABARAPL1 tumor suppressive function is independent of its conjugation to autophagosomes in MCF-7 breast cancer cells

https://doi.org/10.18632/oncotarget.19639

Laura Poillet-Perez, Marine Jacquet, Eric Hervouet, Thierry Gauthier, Annick Fraichard, Christophe Borg, Jean-René Pallandre, Bruno J. Gonzalez, Yasmina Ramdani, Michaël Boyer-Guittaut, Régis Delage-Mourroux,  and Gilles Despouy
55998-56020
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Research Papers

IL1 genes polymorphism and the risk of renal cell carcinoma in Chinese Han population

IL1 genes polymorphism and the risk of renal cell carcinoma in Chinese Han population

https://doi.org/10.18632/oncotarget.18715

Fei Wang, Yingai Zhang, Shunlan Wang, Yadong Zhang, Dinglan Wu, Chong Zhang, Yuanhui Gao, Xi Liu, Weifu Wang,  and Shufang Zhang
56021-56029
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P62 plasmid can alleviate diet-induced obesity and metabolic dysfunctions

P62 plasmid can alleviate diet-induced obesity and metabolic dysfunctions

https://doi.org/10.18632/oncotarget.19840

Tatiana Halenova, Oleksii Savchuk, Ludmila Ostapchenko, Andrey Chursov, Nathan Fridlyand, Andrey B. Komissarov, Franco Venanzi, Sergey I. Kolesnikov, Albert A. Sufianov, Michael Y. Sherman, Vladimir L. Gabai,  and Alexander M. Shneider
56030-56040
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Down-regulation of NTCP expression by cyclin D1 in hepatitis B virus-related hepatocellular carcinoma has clinical significance

Down-regulation of NTCP expression by cyclin D1 in hepatitis B virus-related hepatocellular carcinoma has clinical significance

https://doi.org/10.18632/oncotarget.10241

Jingting Kang, Jie Wang, Jin Cheng, Zhiliang Cao, Ran Chen, Huiyu Li, Shuang Liu, Xiangmei Chen, Jianhua Sui,  and Fengmin Lu
56041-56050
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Lipid catabolism inhibition sensitizes prostate cancer cells to antiandrogen blockade

Lipid catabolism inhibition sensitizes prostate cancer cells to antiandrogen blockade

https://doi.org/10.18632/oncotarget.17359

Thomas W. Flaig, Maren Salzmann-Sullivan, Lih-Jen Su, Zhiyong Zhang, Molishree Joshi, Miguel A. Gijón, Jihye Kim, John J. Arcaroli, Adrie Van Bokhoven, M. Scott Lucia, Francisco G. La Rosa,  and Isabel R. Schlaepfer
56051-56065
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Comparative study of whole genome amplification and next generation sequencing performance of single cancer cells

Comparative study of whole genome amplification and next generation sequencing performance of single cancer cells

https://doi.org/10.18632/oncotarget.10701

Anna Babayan, Malik Alawi, Michael Gormley, Volkmar Müller, Harriet Wikman, Ryan P. McMullin, Denis A. Smirnov, Weimin Li, Maria Geffken, Klaus Pantel,  and Simon A. Joosse
56066-56080
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Hexokinase 2 promotes tumor growth and metastasis by regulating lactate production in pancreatic cancer

Hexokinase 2 promotes tumor growth and metastasis by regulating lactate production in pancreatic cancer

https://doi.org/10.18632/oncotarget.9760

Marybeth Anderson, Raoud Marayati, Richard Moffitt,  and Jen Jen Yeh
56081-56094
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Hepatic B cell leukemia-3 suppresses chemically-induced hepatocarcinogenesis in mice through altered MAPK and NF-κB activation

Hepatic B cell leukemia-3 suppresses chemically-induced hepatocarcinogenesis in mice through altered MAPK and NF-κB activation

https://doi.org/10.18632/oncotarget.10893

Nadine Gehrke, Marcus A. Wörns, Amrit Mann, Yvonne Huber, Nadine Hoevelmeyer, Thomas Longerich, Ari Waisman, Peter R. Galle,  and Jörn M. Schattenberg
56095-56109
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Vorinostat suppresses hypoxia signaling by modulating nuclear translocation of hypoxia inducible factor 1 alpha

Vorinostat suppresses hypoxia signaling by modulating nuclear translocation of hypoxia inducible factor 1 alpha

https://doi.org/10.18632/oncotarget.18125

Chao Zhang, Chunzhang Yang, Michael J. Feldman, Herui Wang, Ying Pang, Dominic M. Maggio, Dongwang Zhu, Cody L. Nesvick, Pauline Dmitriev, Petra Bullova, Prashant Chittiboina, Roscoe O. Brady, Karel Pacak,  and Zhengping Zhuang
56110-56125
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Targeting hypoxic cancer stem cells (CSCs) with Doxycycline: Implications for optimizing anti-angiogenic therapy

Targeting hypoxic cancer stem cells (CSCs) with Doxycycline: Implications for optimizing anti-angiogenic therapy

https://doi.org/10.18632/oncotarget.18445

Ernestina Marianna De Francesco, Marcello Maggiolini, Herbert B. Tanowitz, Federica Sotgia,  and Michael P. Lisanti
56126-56142
Abstract  |  PDF  |  HTML  |  Order a Reprint

MicroRNA profiling associated with non-small cell lung cancer: next generation sequencing detection, experimental validation, and prognostic value

MicroRNA profiling associated with non-small cell lung cancer: next generation sequencing detection, experimental validation, and prognostic value

https://doi.org/10.18632/oncotarget.18603

Sandra Gallach, Eloisa Jantus-Lewintre, Silvia Calabuig-Fariñas, David Montaner, Sergio Alonso, Rafael Sirera, Ana Blasco, Marta Usó, Ricardo Guijarro, Miguel Martorell,  and Carlos Camps
56143-56157
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Molecular and functional characterization of a new 3′ end KIT juxtamembrane deletion in a duodenal GIST treated with neoadjuvant Imatinib

Molecular and functional characterization of a new 3′ end KIT juxtamembrane deletion in a duodenal GIST treated with neoadjuvant Imatinib

https://doi.org/10.18632/oncotarget.19341

Vittorio Perfetti, Erik Laurini, Suzana Aulić, Maurizio Fermeglia, Roberta Riboni, Marco Lucioni, Elena Dallera, Sara Delfanti, Luigi Pugliese, Francesco Saverio Latteri, Andrea Pietrabissa,  and Sabrina Pricl
56158-56167
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Up-regulation of LINC00161 correlates with tumor migration and invasion and poor prognosis of patients with hepatocellular carcinoma

Up-regulation of LINC00161 correlates with tumor migration and invasion and poor prognosis of patients with hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.17040

Li-Chao Xu, Quan-Ning Chen, Xi-Qiang Liu, Xiao-Ming Wang, Qi-Meng Chang, Qi Pan, Lu Wang,  and Yi-Lin Wang
56168-56173
Abstract  |  PDF  |  HTML  |  Order a Reprint

MicroRNA-610 suppresses osteosarcoma oncogenicity via targeting TWIST1 expression

MicroRNA-610 suppresses osteosarcoma oncogenicity via targeting TWIST1 expression

https://doi.org/10.18632/oncotarget.17045

Chi Jin, Yongjian Feng, Yongjian Ni,  and Zhonglin Shan
56174-56184
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

N-Acetylcysteine breaks resistance to trastuzumab caused by MUC4 overexpression in human HER2 positive BC-bearing nude mice monitored by 89Zr-Trastuzumab and 18F-FDG PET imaging

N-Acetylcysteine breaks resistance to trastuzumab caused by MUC4 overexpression in human HER2 positive BC-bearing nude mice monitored by 89Zr-Trastuzumab and 18F-FDG PET imaging

https://doi.org/10.18632/oncotarget.17015

Zéna Wimana, Geraldine Gebhart, Thomas Guiot, Bruno Vanderlinden, Denis Larsimont, Gilles Doumont, Gaetan Van Simaeys, Serge Goldman, Patrick Flamen,  and Ghanem Ghanem
56185-56198
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A phase 1 dose-escalation study of the oral histone deacetylase inhibitor abexinostat in combination with standard hypofractionated radiotherapy in advanced solid tumors

A phase 1 dose-escalation study of the oral histone deacetylase inhibitor abexinostat in combination with standard hypofractionated radiotherapy in advanced solid tumors

https://doi.org/10.18632/oncotarget.14147

Eric Deutsch, Elizabeth Cohen-Jonathan Moyal, Vanesa Gregorc, Paolo Andrea Zucali, Jean Menard, Jean-Charles Soria, Ioana Kloos, Jeff Hsu, Ying Luan, Emily Liu, Remus Vezan, Thorsten Graef,  and Sofia Rivera
56199-56209
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Time dependent modulation of tumor radiosensitivity by a pan HDAC inhibitor: abexinostat

Time dependent modulation of tumor radiosensitivity by a pan HDAC inhibitor: abexinostat

https://doi.org/10.18632/oncotarget.14813

Sofia Rivera, Céline Leteur, Frédérique Mégnin, Frédéric Law, Isabelle Martins, Ioana Kloos, Stéphane Depil, Nazanine Modjtahedi, Jean Luc Perfettini, Christophe Hennequin,  and Eric Deutsch
56210-56227
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Hepatitis C virus core protein targets 4E-BP1 expression and phosphorylation and potentiates Myc-induced liver carcinogenesis in transgenic mice

Hepatitis C virus core protein targets 4E-BP1 expression and phosphorylation and potentiates Myc-induced liver carcinogenesis in transgenic mice

https://doi.org/10.18632/oncotarget.17280

Cosette Abdallah, Charlène Lejamtel, Nassima Benzoubir, Serena Battaglia, Nazha Sidahmed-Adrar, Christophe Desterke, Matthieu Lemasson, Arielle R. Rosenberg, Didier Samuel, Christian Bréchot, Delphine Pflieger, François Le Naour,  and Marie-Françoise Bourgeade
56228-56242
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Expression and release of glucose-regulated protein-78 (GRP78) in multiple myeloma

Expression and release of glucose-regulated protein-78 (GRP78) in multiple myeloma

https://doi.org/10.18632/oncotarget.17353

Normann Steiner, Bojana Borjan, Roman Hajek, Karin Jöhrer, Georg Göbel, Wolfgang Willenbacher, Johann Kern, Eberhard Gunsilius,  and Gerold Untergasser
56243-56254
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

FoxR2 promotes glioma proliferation by suppression of the p27 pathway

FoxR2 promotes glioma proliferation by suppression of the p27 pathway

https://doi.org/10.18632/oncotarget.17447

Xuejiao Liu, Ning Liu, Chenglong Yue, Dacheng Wang, Zhenglei Qi, Yiming Tu, Guokun Zhuang, Di Zhou, Shangfeng Gao, Mingshan Niu,  and Rutong Yu
56255-56266
Abstract  |  PDF  |  HTML  |  Order a Reprint

Casticin attenuates liver fibrosis and hepatic stellate cell activation by blocking TGF-β/Smad signaling pathway

Casticin attenuates liver fibrosis and hepatic stellate cell activation by blocking TGF-β/Smad signaling pathway

https://doi.org/10.18632/oncotarget.17453

Ling Zhou, Xiaoying Dong, Linlin Wang, Lanlan Shan, Ting Li, Wanfu Xu, Yan Ding, Mingqiang Lai, Xiaojun Lin, Meng Dai, Xiaochun Bai, Chunhong Jia,  and Hang Zheng
56267-56280
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Combination of DESI2 and IP10 gene therapy significantly improves therapeutic efficacy against murine carcinoma

Combination of DESI2 and IP10 gene therapy significantly improves therapeutic efficacy against murine carcinoma

https://doi.org/10.18632/oncotarget.17623

Chao Lin, HuaYing Yan, Jun Yang, Lei Li, Mei Tang, Xinyu Zhao, Chunlai Nie, Na Luo, Yuquan Wei,  and Zhu Yuan
56281-56295
Abstract  |  PDF  |  HTML  |  Order a Reprint

Eugenol alleviated breast precancerous lesions through HER2/ PI3K-AKT pathway-induced cell apoptosis and S-phase arrest

Eugenol alleviated breast precancerous lesions through HER2/ PI3K-AKT pathway-induced cell apoptosis and S-phase arrest

https://doi.org/10.18632/oncotarget.17626

Min Ma, Yi Ma, Gui-Juan Zhang, Rui Liao, Xue-Feng Jiang, Xian-Xin Yan, Feng-Jie Bie, Xiao-Bo Li,  and Yan-Hong Lv
56296-56310
Abstract  |  PDF  |  HTML  |  Order a Reprint

Targeted alpha therapy using a novel CD70 targeted thorium-227 conjugate in in vitro and in vivo models of renal cell carcinoma

Targeted alpha therapy using a novel CD70 targeted thorium-227 conjugate in in vitro and in vivo models of renal cell carcinoma

https://doi.org/10.18632/oncotarget.16910

Urs B. Hagemann, Dessislava Mihaylova, Steinar R. Uran, Joergen Borrebaek, Derek Grant, Roger M. Bjerke, Jenny Karlsson,  and Alan S. Cuthbertson
56311-56326
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A novel EGFR-TKI inhibitor (cAMP-H3BO3 complex) combined with thermal therapy is a promising strategy to improve lung cancer treatment outcomes

A novel EGFR-TKI inhibitor (cAMP-H3BO3 complex) combined with thermal therapy is a promising strategy to improve lung cancer treatment outcomes

https://doi.org/10.18632/oncotarget.17628

Yongpeng Tong, Chunliu Huang,  and Junfang Zhang
56327-56337
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Identification of precision treatment strategies for relapsed/ refractory multiple myeloma by functional drug sensitivity testing

Identification of precision treatment strategies for relapsed/ refractory multiple myeloma by functional drug sensitivity testing

https://doi.org/10.18632/oncotarget.17630

Muntasir Mamun Majumder, Raija Silvennoinen, Pekka Anttila, David Tamborero, Samuli Eldfors, Bhagwan Yadav, Riikka Karjalainen, Heikki Kuusanmäki, Juha Lievonen, Alun Parsons, Minna Suvela, Esa Jantunen, Kimmo Porkka,  and Caroline A. Heckman
56338-56350
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Baicalein inhibits pancreatic cancer cell proliferation and invasion via suppression of NEDD9 expression and its downstream Akt and ERK signaling pathways

Baicalein inhibits pancreatic cancer cell proliferation and invasion via suppression of NEDD9 expression and its downstream Akt and ERK signaling pathways

https://doi.org/10.18632/oncotarget.16912

Rong-Tao Zhou, Mei He, Ze Yu, Yang Liang, Yuzhe Nie, Sheng Tai,  and Chun-Bo Teng
56351-56363
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Androgen receptor expression identifies patient with favorable outcome in operable triple negative breast cancer

Androgen receptor expression identifies patient with favorable outcome in operable triple negative breast cancer

https://doi.org/10.18632/oncotarget.16913

Xiao-Qing Hu, Wei-Li Chen, Hai-Guang Ma,  and Ke Jiang
56364-56374
Abstract  |  PDF  |  HTML  |  Order a Reprint

IL-8 promotes inflammatory mediators and stimulates activation of p38 MAPK/ERK-NF-κB pathway and reduction of JNK in HNSCC

IL-8 promotes inflammatory mediators and stimulates activation of p38 MAPK/ERK-NF-κB pathway and reduction of JNK in HNSCC

https://doi.org/10.18632/oncotarget.16914

Leong-Perng Chan, Cheng Liu, Feng-Yu Chiang, Ling-Feng Wang, Ka-Wo Lee, Wan-Ting Chen, Po-Lin Kuo,  and Chia-Hua Liang
56375-56388
Abstract  |  PDF  |  HTML  |  Order a Reprint

Urine miR-21-5p as a potential non-invasive biomarker for gastric cancer

Urine miR-21-5p as a potential non-invasive biomarker for gastric cancer

https://doi.org/10.18632/oncotarget.16916

Hsiao-Wei Kao, Chao-Yu Pan, Chun-Hung Lai, Chew-Wun Wu, Wen-Liang Fang, Kuo-Hung Huang,  and Wen-Chang Lin
56389-56397
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Copy number variations of circulating, cell-free DNA in urothelial carcinoma of the bladder patients treated with radical cystectomy: a prospective study

Copy number variations of circulating, cell-free DNA in urothelial carcinoma of the bladder patients treated with radical cystectomy: a prospective study

https://doi.org/10.18632/oncotarget.17657

Armin Soave, Felix K.H. Chun, Timo Hillebrand, Michael Rink, Lars Weisbach, Bettina Steinbach, Margit Fisch, Klaus Pantel,  and Heidi Schwarzenbach
56398-56407
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Tumor vasculogenic mimicry formation as an unfavorable prognostic indicator in patients with breast cancer

Tumor vasculogenic mimicry formation as an unfavorable prognostic indicator in patients with breast cancer

https://doi.org/10.18632/oncotarget.16919

Yanwei Shen, Jianfeng Quan, Mengying Wang, Shuting Li, Jiao Yang, Meng Lv, Zheling Chen, Lingxiao Zhang, Xiaoai Zhao,  and Jin Yang
56408-56416
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MiR-148a impairs Ras/ERK signaling in B lymphocytes by targeting SOS proteins

MiR-148a impairs Ras/ERK signaling in B lymphocytes by targeting SOS proteins

https://doi.org/10.18632/oncotarget.17662

Julia Alles, Nicole Ludwig, Stefanie Rheinheimer, Petra Leidinger, Friedrich A. Grässer, Andreas Keller,  and Eckart Meese
56417-56427
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Increased expression of calponin 2 is a positive prognostic factor in pancreatic ductal adenocarcinoma

Increased expression of calponin 2 is a positive prognostic factor in pancreatic ductal adenocarcinoma

https://doi.org/10.18632/oncotarget.17701

Zhaoyan Qiu, Yi Chu, Bing Xu, Qian Wang, Mingzuo Jiang, Xiaowei Li, Gang Wang, Pengfei Yu, Guoxiao Liu, Hua Wang, Huijie Kang, Jiayu Liu, Yu Zhang, Jian-Ping Jin, Kaichun Wu,  and Jie Liang
56428-56442
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Estrogen promotes tumor metastasis via estrogen receptor beta-mediated regulation of matrix-metalloproteinase-2 in non-small cell lung cancer

Estrogen promotes tumor metastasis via estrogen receptor beta-mediated regulation of matrix-metalloproteinase-2 in non-small cell lung cancer

https://doi.org/10.18632/oncotarget.16992

Sheng Fan, Yongde Liao, Changyu Liu, Quanfu Huang, Huifang Liang, Bo Ai, Shegnling Fu,  and Sheng Zhou
56443-56459
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Overexpression of a functional calcium-sensing receptor dramatically increases osteolytic potential of MDA-MB-231 cells in a mouse model of bone metastasis through epiregulin-mediated osteoprotegerin downregulation

Overexpression of a functional calcium-sensing receptor dramatically increases osteolytic potential of MDA-MB-231 cells in a mouse model of bone metastasis through epiregulin-mediated osteoprotegerin downregulation

https://doi.org/10.18632/oncotarget.16999

Cédric Boudot, Lucie Hénaut, Ursula Thiem, Sandra Geraci, Mariangela Galante, Paulo Saldanha, Zuzana Saidak, Isabelle Six, Philippe Clézardin, Said Kamel,  and Romuald Mentaverri
56460-56472
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

HSP90 inhibitor 17-DMAG exerts anticancer effects against gastric cancer cells principally by altering oxidant-antioxidant balance

HSP90 inhibitor 17-DMAG exerts anticancer effects against gastric cancer cells principally by altering oxidant-antioxidant balance

https://doi.org/10.18632/oncotarget.17007

Jeong Goo Kim, Sang Chul Lee, Ok-Hee Kim, Kee-Hwan Kim, Kyo Young Song, Sang Kuon Lee, Byung Jo Choi, Wonjun Jeong,  and Say-June Kim
56473-56489
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Proteolytic cleavages in the extracellular domain of receptor tyrosine kinases by membrane-associated serine proteases

Proteolytic cleavages in the extracellular domain of receptor tyrosine kinases by membrane-associated serine proteases

https://doi.org/10.18632/oncotarget.17009

Li-Mei Chen,  and Karl X. Chai
56490-56505
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Coal tar pitch extract could induce chromosomal instability of human bronchial epithelial cells mediated by spindle checkpoint-related proteins

Coal tar pitch extract could induce chromosomal instability of human bronchial epithelial cells mediated by spindle checkpoint-related proteins

https://doi.org/10.18632/oncotarget.17025

Peng Zhang, Zhitao Li, Na Wang, Guangcai Duan, Wei Wang, Yanming Feng, Yong Zhao, Lixia Wang, Hansong Zhu, Qiao Zhang, Xiaozhuan Liu, Weidong Wu, Yongjun Wu, Wu Yao, Jing Wang, Yiming Wu,  and Feifei Feng
56506-56517
Abstract  |  PDF  |  HTML  |  Order a Reprint

A genome-wide microRNA profiling indicates miR-424-5p and miR-503-5p as regulators of ALK expression in neuroblastoma

A genome-wide microRNA profiling indicates miR-424-5p and miR-503-5p as regulators of ALK expression in neuroblastoma

https://doi.org/10.18632/oncotarget.17033

Marilena De Mariano, Sara Stigliani, Stefano Moretti, Federica Parodi, Michela Croce, Cinzia Bernardi, Aldo Pagano, Gian Paolo Tonini, Silvano Ferrini,  and Luca Longo
56518-56532
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Polymorphisms of pri-miR-219-1 are associated with the susceptibility and prognosis of non-small cell lung cancer in a Northeast Chinese population

Polymorphisms of pri-miR-219-1 are associated with the susceptibility and prognosis of non-small cell lung cancer in a Northeast Chinese population

https://doi.org/10.18632/oncotarget.17035

Chang Zheng, Xuelian Li, Lingzi Xia, Xue Fang, Xiaowei Quan, Zhihua Yin, Yuxia Zhao,  and Baosen Zhou
56533-56541
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MiR-451 as a new tumor marker for gastric cancer

MiR-451 as a new tumor marker for gastric cancer

https://doi.org/10.18632/oncotarget.17239

Yong Shen, Jiao-Mei Gong, Li-Li Zhou,  and Jia-He Sheng
56542-56545
Abstract  |  PDF  |  HTML  |  Order a Reprint

Metformin increases chemo-sensitivity via gene downregulation encoding DNA replication proteins in 5-Fu resistant colorectal cancer cells

Metformin increases chemo-sensitivity via gene downregulation encoding DNA replication proteins in 5-Fu resistant colorectal cancer cells

https://doi.org/10.18632/oncotarget.17798

Sung-Hee Kim, Soon-Chan Kim,  and Ja-Lok Ku
56546-56557
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The roles of ING5 in gliomas: a good marker for tumorigenesis and a potential target for gene therapy

The roles of ING5 in gliomas: a good marker for tumorigenesis and a potential target for gene therapy

https://doi.org/10.18632/oncotarget.17802

Shuang Zhao, Zhi-Juan Zhao, Hao-Yu He, Ji-Cheng Wu, Xiao-Qing Ding, Lei Yang, Ning Jia, Zhi-Jie Li,  and Hua-Chuan Zheng
56558-56568
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Alternative promotion and suppression of metastasis by JNK2 governed by its phosphorylation

Alternative promotion and suppression of metastasis by JNK2 governed by its phosphorylation

https://doi.org/10.18632/oncotarget.17507

Sike Hu, Xiaoli Dong, Wenjuan Gao, Dwayne Stupack, Yanhua Liu, Rong Xiang,  and Na Li
56569-56581
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Mitochondrial protein 18 (MTP18) plays a pro-apoptotic role in chemotherapy-induced gastric cancer cell apoptosis

Mitochondrial protein 18 (MTP18) plays a pro-apoptotic role in chemotherapy-induced gastric cancer cell apoptosis

https://doi.org/10.18632/oncotarget.17508

Lynn H.H. Aung, Ruibei Li, Bellur S. Prabhakar, Ajay V. Maker,  and Peifeng Li
56582-56597
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Expression of CD38 in myeloma bone niche: A rational basis for the use of anti-CD38 immunotherapy to inhibit osteoclast formation

Expression of CD38 in myeloma bone niche: A rational basis for the use of anti-CD38 immunotherapy to inhibit osteoclast formation

https://doi.org/10.18632/oncotarget.17896

Federica Costa, Denise Toscani, Antonella Chillemi, Valeria Quarona, Marina Bolzoni, Valentina Marchica, Rosanna Vescovini, Cristina Mancini, Eugenia Martella, Nicoletta Campanini, Chiara Schifano, Sabrina Bonomini, Fabrizio Accardi, Alberto L. Horenstein, Franco Aversa, Fabio Malavasi,  and Nicola Giuliani
56598-56611
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

TDP-43/HDAC6 axis promoted tumor progression and regulated nutrient deprivation-induced autophagy in glioblastoma

TDP-43/HDAC6 axis promoted tumor progression and regulated nutrient deprivation-induced autophagy in glioblastoma

https://doi.org/10.18632/oncotarget.17979

Tzu-Wei Lin, Ming-Teh Chen, Liang-Tin Lin, Pin-I Huang, Wen-Liang Lo, Yi-Ping Yang, Kai-Hsi Lu, Yi-Wei Chen, Shih-Hwa Chiou,  and Cheng-Wen Wu
56612-56625
Abstract  |  PDF  |  HTML  |  Order a Reprint

Predictive factors of pathologic complete response in HER2-positive and axillary lymph node positive breast cancer after neoadjuvant paclitaxel, carboplatin plus with trastuzumab

Predictive factors of pathologic complete response in HER2-positive and axillary lymph node positive breast cancer after neoadjuvant paclitaxel, carboplatin plus with trastuzumab

https://doi.org/10.18632/oncotarget.17993

Jinhua Ding, Yinlong Yang, Li Jiang, Weizhu Wu,  and Zhiming Shao
56626-56634
Abstract  |  PDF  |  HTML  |  Order a Reprint

Suppression of miR-16 promotes tumor growth and metastasis through reversely regulating YAP1 in human cholangiocarcinoma

Suppression of miR-16 promotes tumor growth and metastasis through reversely regulating YAP1 in human cholangiocarcinoma

https://doi.org/10.18632/oncotarget.17832

Sheng Han, Dong Wang, Guohua Tang, Xinxiang Yang, Chenyu Jiao, Renjie Yang, Yaodong Zhang, Liqun Huo, Zicheng Shao, Zefa Lu, Jiawei Zhang,  and Xiangcheng Li
56635-56650
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Autosomal InDel polymorphisms for population genetic structure and differentiation analysis of Chinese Kazak ethnic group

Autosomal InDel polymorphisms for population genetic structure and differentiation analysis of Chinese Kazak ethnic group

https://doi.org/10.18632/oncotarget.17838

Tingting Kong, Yahao Chen, Yuxin Guo, Yuanyuan Wei, Xiaoye Jin, Tong Xie, Yuling Mu, Qian Dong, Shaoqing Wen, Boyan Zhou, Li Zhang, Chunmei Shen,  and Bofeng Zhu
56651-56658
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

PRPF overexpression induces drug resistance through actin cytoskeleton rearrangement and epithelial-mesenchymal transition

PRPF overexpression induces drug resistance through actin cytoskeleton rearrangement and epithelial-mesenchymal transition

https://doi.org/10.18632/oncotarget.17855

Salman Ul Islam, Adeeb Shehzad, Jong Kyung Sonn,  and Young Sup Lee
56659-56671
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Wip1 is associated with tumorigenity and metastasis through MMP-2 in human intrahepatic cholangiocarcinoma

Wip1 is associated with tumorigenity and metastasis through MMP-2 in human intrahepatic cholangiocarcinoma

https://doi.org/10.18632/oncotarget.18074

Sulai Liu, Bo Jiang, Hao Li, Zili He, Pin Lv, Chuang Peng, Yonggang Wang, Wei Cheng, Zhengquan Xu, Wei Chen, Zhengkai Liu, Bao Zhang, Shengqian Shen,  and Shuanglin Xiang
56672-56683
Abstract  |  PDF  |  HTML  |  Order a Reprint

Genomic analysis–integrated whole-exome sequencing of neuroblastomas identifies genetic mutations in axon guidance pathway

Genomic analysis–integrated whole-exome sequencing of neuroblastomas identifies genetic mutations in axon guidance pathway

https://doi.org/10.18632/oncotarget.18079

Yuanyuan Li, Miki Ohira, Yong Zhou, Teng Xiong, Wen Luo, Chao Yang, Xiangchun Li, Zhibo Gao, Rui Zhou, Yohko Nakamura, Takehiko Kamijo, Yasuhiko Kaneko, Takeshi Taketani, Junichi Ueyama, Tatsuro Tajiri, Hongyan Zhang, Jian Wang, Huanming Yang, Ye Yin,  and Akira Nakagawara
56684-56697
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Inhibition of the PI3K/AKT/mTOR pathway activates autophagy and compensatory Ras/Raf/MEK/ERK signalling in prostate cancer

Inhibition of the PI3K/AKT/mTOR pathway activates autophagy and compensatory Ras/Raf/MEK/ERK signalling in prostate cancer

https://doi.org/10.18632/oncotarget.18082

Dominika E. Butler, Christopher Marlein, Hannah F. Walker, Fiona M. Frame, Vincent M. Mann, Matthew S. Simms, Barry R. Davies, Anne T. Collins,  and Norman J. Maitland
56698-56713
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Microwave ablation combined with EGFR-TKIs versus only EGFR-TKIs in advanced NSCLC patients with EGFR-sensitive mutations

Microwave ablation combined with EGFR-TKIs versus only EGFR-TKIs in advanced NSCLC patients with EGFR-sensitive mutations

https://doi.org/10.18632/oncotarget.18083

Zhigang Wei, Xin Ye, Xia Yang, Aimin Zheng, Guanghui Huang, Wenhong Li, Jiao Wang, Xiaoying Han, Min Meng,  and Yang Ni
56714-56725
Abstract  |  PDF  |  HTML  |  Order a Reprint

Long-term cigarette smoke exposure inhibits histone deacetylase 2 expression and enhances the nuclear factor-κB activation in skeletal muscle of mice

Long-term cigarette smoke exposure inhibits histone deacetylase 2 expression and enhances the nuclear factor-κB activation in skeletal muscle of mice

https://doi.org/10.18632/oncotarget.18089

Dongmei Huang, Zhiying Ma, Yili He, Ying Xiao, Honglin Luo, Qiuli Liang, Xiaoning Zhong, Jing Bai,  and Zhiyi He
56726-56736
Abstract  |  PDF  |  HTML  |  Order a Reprint

HDL-cholesterol concentration in pregnant Chinese Han women of late second trimester associated with genetic variants in CETP, ABCA1, APOC3, and GALNT2

HDL-cholesterol concentration in pregnant Chinese Han women of late second trimester associated with genetic variants in CETP, ABCA1, APOC3, and GALNT2

https://doi.org/10.18632/oncotarget.18128

Mingxuan Cui, Wei Li, Liangkun Ma, Fan Ping, Juntao Liu, Xueyan Wu, Jiangfeng Mao, Xi Wang,  and Min Nie
56737-56746
Abstract  |  PDF  |  HTML  |  Order a Reprint

Panobinostat, a histone deacetylase inhibitor, suppresses leptomeningeal seeding in a medulloblastoma animal model

Panobinostat, a histone deacetylase inhibitor, suppresses leptomeningeal seeding in a medulloblastoma animal model

https://doi.org/10.18632/oncotarget.18132

Ji Hoon Phi, Seung Ah Choi, Pil Ae Kwak, Ji Yeoun Lee, Kyu-Chang Wang, Do Won Hwang,  and Seung-Ki Kim
56747-56757
Abstract  |  PDF  |  HTML  |  Order a Reprint

Clinicopathological and prognostic significance of c-Met overexpression in breast cancer

Clinicopathological and prognostic significance of c-Met overexpression in breast cancer

https://doi.org/10.18632/oncotarget.18142

Xixi Zhao, Jingkun Qu, Yuxin Hui, Hong Zhang, Yuchen Sun, Xu Liu, Xiaoyao Zhao, Zitong Zhao, Qian Yang, Feidi Wang,  and Shuqun Zhang
56758-56767
Abstract  |  PDF  |  HTML  |  Order a Reprint

IER3IP1 deficiency leads to increased β-cell death and decreased β-cell proliferation

IER3IP1 deficiency leads to increased β-cell death and decreased β-cell proliferation

https://doi.org/10.18632/oncotarget.18179

Juan Sun,  and Decheng Ren
56768-56779
Abstract  |  PDF  |  HTML  |  Order a Reprint

CASP8 -652 6N insertion/deletion polymorphism and overall cancer risk: evidence from 49 studies

CASP8 -652 6N insertion/deletion polymorphism and overall cancer risk: evidence from 49 studies

https://doi.org/10.18632/oncotarget.18187

Jiarong Cai, Qingjian Ye, Suling Luo, Ze Zhuang, Kui He, Zhen-Jian Zhuo, Xiaochun Wan,  and Juan Cheng
56780-56790
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

In vivo autophagy and biogenesis of autophagosomes within male haploid cells during spermiogenesis

In vivo autophagy and biogenesis of autophagosomes within male haploid cells during spermiogenesis

https://doi.org/10.18632/oncotarget.18221

Ping Yang, Nisar Ahmed, Lingling Wang, Hong Chen, Yasir Waqas, Tengfei Liu, Abdul Haseeb, Nasrullah Bangulzai, Yufei Huang,  and Qiusheng Chen
56791-56801
Abstract  |  PDF  |  HTML  |  Order a Reprint

Decitabine inhibits T cell proliferation via a novel TET2-dependent mechanism and exerts potent protective effect in mouse auto- and allo-immunity models

Decitabine inhibits T cell proliferation via a novel TET2-dependent mechanism and exerts potent protective effect in mouse auto- and allo-immunity models

https://doi.org/10.18632/oncotarget.18063

Xue Wang, Jun Wang, Yong Yu, Tonghui Ma, Ping Chen, Bing Zhou,  and Ran Tao
56802-56815
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Selection of optimal molecular targets for tumor-specific imaging in pancreatic ductal adenocarcinoma

Selection of optimal molecular targets for tumor-specific imaging in pancreatic ductal adenocarcinoma

https://doi.org/10.18632/oncotarget.18232

Willemieke S. Tummers, Arantza Farina-Sarasqueta, Martin C. Boonstra, Hendrica A. Prevoo, Cornelis F. Sier, Jan S. Mieog, Johannes Morreau, Casper H. van Eijck, Peter J. Kuppen, Cornelis J. van de Velde, Bert A. Bonsing, Alexander L. Vahrmeijer,  and Rutger-Jan Swijnenburg
56816-56828
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

DNA methylation signature of long noncoding RNA genes during human pre-implantation embryonic development

DNA methylation signature of long noncoding RNA genes during human pre-implantation embryonic development

https://doi.org/10.18632/oncotarget.18072

Jingyu Li, Wei Han, Xiaoli Shen, Shubiao Han, Hong Ye,  and Guoning Huang
56829-56838
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Dysregulation of an X-linked primate-specific epididymal microRNA cluster in unexplained asthenozoospermia

Dysregulation of an X-linked primate-specific epididymal microRNA cluster in unexplained asthenozoospermia

https://doi.org/10.18632/oncotarget.18076

Xingrong Qing, Jian Shi, Tingting Dong, Chunlin Wu, Lian Hu,  and Honggang Li
56839-56849
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Role of glucose metabolism related gene GLUT1 in the occurrence and prognosis of colorectal cancer

Role of glucose metabolism related gene GLUT1 in the occurrence and prognosis of colorectal cancer

https://doi.org/10.18632/oncotarget.18090

Wenming Feng, Ge Cui, Cheng-wu Tang, Xiao-lan Zhang, Chuang Dai, Yong-qiang Xu, Hui Gong, Tao Xue, Hui-hui Guo,  and Ying Bao
56850-56857
Abstract  |  PDF  |  HTML  |  Order a Reprint

BTK suppresses myeloma cellular senescence through activating AKT/P27/Rb signaling

BTK suppresses myeloma cellular senescence through activating AKT/P27/Rb signaling

https://doi.org/10.18632/oncotarget.18096

Chunyan Gu, Hailin Peng, Yue Lu, Hongbao Yang, Zhidan Tian, Gang Yin, Wen Zhang, Sicheng Lu, Yi Zhang,  and Ye Yang
56858-56867
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Oleoylethanolamide inhibits α-melanocyte stimulating hormone-stimulated melanogenesis via ERK, Akt and CREB signaling pathways in B16 melanoma cells

Oleoylethanolamide inhibits α-melanocyte stimulating hormone-stimulated melanogenesis via ERK, Akt and CREB signaling pathways in B16 melanoma cells

https://doi.org/10.18632/oncotarget.18097

Juan Zhou, Tong Ren, Ying Li, Anran Cheng, Wanyi Xie, Lanxi Xu, Lu Peng, Jinbin Lin, Lianxiang Lian, Yong Diao, Xin Jin,  and Lichao Yang
56868-56879
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Heptamethine carbocyanine DZ-1 dye for near-infrared fluorescence imaging of hepatocellular carcinoma

Heptamethine carbocyanine DZ-1 dye for near-infrared fluorescence imaging of hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.18131

Jiaze An, Ningning Zhao, Caiqin Zhang, Yong Zhao, Dengxu Tan, Ya Zhao, Bing Bai, Hai Zhang, Boyang Jason Wu,  and Changhong Shi
56880-56892
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Marsdenia tenacissima extract overcomes Axl- and Met-mediated erlotinib and gefitinib cross-resistance in non-small cell lung cancer cells

Marsdenia tenacissima extract overcomes Axl- and Met-mediated erlotinib and gefitinib cross-resistance in non-small cell lung cancer cells

https://doi.org/10.18632/oncotarget.18137

Shu-Yan Han, Wei Zhao, Hai-Bo Han, Hong Sun, Dong Xue, Yan-Na Jiao, Xi-Ran He, Shan-Tong Jiang,  and Ping-Ping Li
56893-56905
Abstract  |  PDF  |  HTML  |  Order a Reprint

Reevaluation of ATR signaling in primary resting chronic lymphocytic leukemia cells: evidence for pro-survival or pro-apoptotic function

Reevaluation of ATR signaling in primary resting chronic lymphocytic leukemia cells: evidence for pro-survival or pro-apoptotic function

https://doi.org/10.18632/oncotarget.18144

Maxime Beyaert, Eliza Starczewska, Ana Cristina González Pérez, Nicolas Vanlangendonck, Pascale Saussoy, Gaëlle Tilman, Anne De Leener, Marie-Christiane Vekemans, Eric Van Den Neste,  and Françoise Bontemps
56906-56920
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A retrospective multicentric observational study of trastuzumab emtansine in HER2 positive metastatic breast cancer: a real-world experience

A retrospective multicentric observational study of trastuzumab emtansine in HER2 positive metastatic breast cancer: a real-world experience

https://doi.org/10.18632/oncotarget.18176

Patrizia Vici, Laura Pizzuti, Andrea Michelotti, Isabella Sperduti, Clara Natoli, Lucia Mentuccia, Luigi Di Lauro, Domenico Sergi, Paolo Marchetti, Daniele Santini, Emanuela Magnolfi, Laura Iezzi, Luca Moscetti, Agnese Fabbri, Alessandra Cassano, Antonino Grassadonia, Claudia Omarini, Federico Piacentini, Andrea Botticelli, Ilaria Bertolini, Angelo Fedele Scinto, Germano Zampa, Maria Mauri, Loretta D’Onofrio, Valentina Sini, Maddalena Barba, Marcello Maugeri-Saccà, Ernesto Rossi, Elisabetta Landucci, Silverio Tomao, Antonio Maria Alberti, Francesco Giotta, Corrado Ficorella, Vincenzo Adamo, Antonio Russo, Vito Lorusso, Katia Cannita, Sandro Barni, Lucio Laudadio, Filippo Greco, Ornella Garrone, Marina Della Giulia, Paolo Marolla, Giuseppe Sanguineti, Barbara Di Cocco, Gennaro Ciliberto, Ruggero De Maria,  and Teresa Gamucci
56921-56931
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Relationship between the TERT, TNIP1 and OBFC1 genetic polymorphisms and susceptibility to colorectal cancer in Chinese Han population

Relationship between the TERT, TNIP1 and OBFC1 genetic polymorphisms and susceptibility to colorectal cancer in Chinese Han population

https://doi.org/10.18632/oncotarget.18378

Chuang Li, Zixuan Zhao, Jun Zhou, Ying Liu, Hao Wang,  and Xinhan Zhao
56932-56941
Abstract  |  PDF  |  HTML  |  Order a Reprint

Phytoagent deoxyelephantopin derivative inhibits triple negative breast cancer cell activity by inducing oxidative stress-mediated paraptosis-like cell death

Phytoagent deoxyelephantopin derivative inhibits triple negative breast cancer cell activity by inducing oxidative stress-mediated paraptosis-like cell death

https://doi.org/10.18632/oncotarget.18183

Jeng-Yuan Shiau, Kyoko Nakagawa-Goto, Kuo-Hsiung Lee,  and Lie-Fen Shyur
56942-56958
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

SOCS1 gene promoter methylation status is associated with in-stent restenosis after percutaneous coronary intervention

SOCS1 gene promoter methylation status is associated with in-stent restenosis after percutaneous coronary intervention

https://doi.org/10.18632/oncotarget.18398

Liang Zhou, Ningfu Wang, Hong Li, Guoxin Tong, Jianmin Yang, Lei Lai, Hao Pan, Xianhua Ye,  and Jinyu Huang
56959-56967
Abstract  |  PDF  |  HTML  |  Order a Reprint

Interleukin-15 stimulates natural killer cell-mediated killing of both human pancreatic cancer and stellate cells

Interleukin-15 stimulates natural killer cell-mediated killing of both human pancreatic cancer and stellate cells

https://doi.org/10.18632/oncotarget.18185

Jonas R.M. Van Audenaerde, Jorrit De Waele, Elly Marcq, Jinthe Van Loenhout, Eva Lion, Johan M.J. Van den Bergh, Ralf Jesenofsky, Atsushi Masamune, Geert Roeyen, Patrick Pauwels, Filip Lardon, Marc Peeters,  and Evelien L.J. Smits
56968-56979
Abstract  |  PDF  |  HTML  |  Order a Reprint

Necroptosis as a potential therapeutic target in multiple organ dysfunction syndrome

Necroptosis as a potential therapeutic target in multiple organ dysfunction syndrome

https://doi.org/10.18632/oncotarget.18252

Yao-Li Cui, Li-Hua Qiu, Shi-Yong Zhou, Lan-Fang Li, Zheng-Zi Qian, Xian-Ming Liu, Hui-Lai Zhang, Xiu-Bao Ren,  and Yong-Qiang Wang
56980-56990
Abstract  |  PDF  |  HTML  |  Order a Reprint

Synergistic suppression of t(8;21)-positive leukemia cell growth by combining oridonin and MAPK1/ERK2 inhibitors

Synergistic suppression of t(8;21)-positive leukemia cell growth by combining oridonin and MAPK1/ERK2 inhibitors

https://doi.org/10.18632/oncotarget.18503

Pavel Spirin, Timofey Lebedev, Natalia Orlova, Alexey Morozov, Nadezhda Poymenova, Sergey E Dmitriev, Anton Buzdin, Carol Stocking, Olga Kovalchuk,  and Vladimir Prassolov
56991-57002
Abstract  |  PDF  |  HTML  |  Order a Reprint

Digoxin-induced anemia among patients with atrial fibrillation and heart failure: clinical data analysis and drug-gene interaction network

Digoxin-induced anemia among patients with atrial fibrillation and heart failure: clinical data analysis and drug-gene interaction network

https://doi.org/10.18632/oncotarget.18504

Yubi Lin, Siqi He, Ruiling Feng, Zhe Xu, Wanqun Chen, Zifeng Huang, Yang Liu, Qianhuan Zhang, Bin Zhang, Kejian Wang,  and Shulin Wu
57003-57011
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MicroRNA-107-5p suppresses non-small cell lung cancer by directly targeting oncogene epidermal growth factor receptor

MicroRNA-107-5p suppresses non-small cell lung cancer by directly targeting oncogene epidermal growth factor receptor

https://doi.org/10.18632/oncotarget.18505

Ping Wang, Xiaomin Liu, Yang Shao, Huimin Wang, Chen Liang, Baohui Han,  and Zhongliang Ma
57012-57023
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Programmed differentiated natural killer cells kill leukemia cells by engaging SLAM family receptors

Programmed differentiated natural killer cells kill leukemia cells by engaging SLAM family receptors

https://doi.org/10.18632/oncotarget.18659

Yang Wu, Young Li, Binqing Fu, Linlin Jin, Xiaohu Zheng, Aimei Zhang, Rui Sun, Zhigang Tian,  and Haiming Wei
57024-57038
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

PLD1 overexpression promotes invasion and migration and function as a risk factor for Chinese glioma patients

PLD1 overexpression promotes invasion and migration and function as a risk factor for Chinese glioma patients

https://doi.org/10.18632/oncotarget.18961

Wenjun Tang, Richu Liang, Yonghong Duan, Qiaoling Shi, Xiaofei Liu,  and Yongshi Liao
57039-57046
Abstract  |  PDF  |  HTML  |  Order a Reprint

Dual targeting of MDM2 and BCL2 as a therapeutic strategy in neuroblastoma

Dual targeting of MDM2 and BCL2 as a therapeutic strategy in neuroblastoma

https://doi.org/10.18632/oncotarget.18982

Alan Van Goethem, Nurten Yigit, Myrthala Moreno-Smith, Sanjeev A. Vasudevan, Eveline Barbieri, Frank Speleman, Jason Shohet, Jo Vandesompele,  and Tom Van Maerken
57047-57057
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Daurinol blocks breast and lung cancer metastasis and development by inhibition of focal adhesion kinase (FAK)

Daurinol blocks breast and lung cancer metastasis and development by inhibition of focal adhesion kinase (FAK)

https://doi.org/10.18632/oncotarget.18983

Jong Kyu Woo, Hyun Jin Jung, Ji-Youn Park, Ju-Hee Kang, Byung Il Lee, Dong Yun Shin, Chu Won Nho, Soo-Young Cho, Je Kyung Seong,  and Seung Hyun Oh
57058-57071
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Notch system is differentially expressed and activated in pituitary adenomas of distinct histotype, tumor cell lines and normal pituitaries

Notch system is differentially expressed and activated in pituitary adenomas of distinct histotype, tumor cell lines and normal pituitaries

https://doi.org/10.18632/oncotarget.19046

Sofia Perrone, Lautaro Zubeldia-Brenner, Elias Gazza, Gianina Demarchi, Leticia Baccarini, Agustin Baricalla, Freya Mertens, Guillermina Luque, Hugo Vankelecom, Silvia Berner, Damasia Becu-Villalobos,  and Carolina Cristina
57072-57088
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Patterns and clinical significance of cervical lymph node metastasis in papillary thyroid cancer patients with Delphian lymph node metastasis

Patterns and clinical significance of cervical lymph node metastasis in papillary thyroid cancer patients with Delphian lymph node metastasis

https://doi.org/10.18632/oncotarget.19047

Guibin Zheng, Hua Zhang, Shaolong Hao, Chengxin Liu, Jie Xu, Jinyao Ning, Guochang Wu, Lixin Jiang, Guojun Li, Haitao Zheng,  and Xicheng Song
57089-57098
Abstract  |  PDF  |  HTML  |  Order a Reprint

The prevalence, subtypes and associated factors of hyperuricemia in lupus nephritis patients at chronic kidney disease stages 1–3

The prevalence, subtypes and associated factors of hyperuricemia in lupus nephritis patients at chronic kidney disease stages 1–3

https://doi.org/10.18632/oncotarget.19051

Simeng Liu, Yijun Gong, Hong Ren, Wen Zhang, Xiaonong Chen, Tong Zhou, Xiao Li,  and Nan Chen
57099-57108
Abstract  |  PDF  |  HTML  |  Order a Reprint

Oxidative stress mediates an increased formation of vascular endothelial growth factor in human hepatocarcinoma cells exposed to erlotinib

Oxidative stress mediates an increased formation of vascular endothelial growth factor in human hepatocarcinoma cells exposed to erlotinib

https://doi.org/10.18632/oncotarget.19055

Nataliya Rohr-Udilova, Florian Klinglmüller, Martha Seif, Hubert Hayden, Martin Bilban, Matthias Pinter, Klaus Stolze, Wolfgang Sieghart, Markus Peck-Radosavljevic,  and Michael Trauner
57109-57120
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Data-driven analysis of immune infiltrate in a large cohort of breast cancer and its association with disease progression, ER activity, and genomic complexity

Data-driven analysis of immune infiltrate in a large cohort of breast cancer and its association with disease progression, ER activity, and genomic complexity

https://doi.org/10.18632/oncotarget.19078

Ruth Dannenfelser, Marianne Nome, Andliena Tahiri, Josie Ursini-Siegel, Hans Kristian Moen Vollan, Vilde D. Haakensen, Åslaug Helland, Bjørn Naume, Carlos Caldas, Anne-Lise Børresen-Dale, Vessela N. Kristensen,  and Olga G. Troyanskaya
57121-57133
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Mass spectrometry-based assay for the molecular diagnosis of glioma: concomitant detection of chromosome 1p/19q codeletion, and IDH1, IDH2, and TERT mutation status

Mass spectrometry-based assay for the molecular diagnosis of glioma: concomitant detection of chromosome 1p/19q codeletion, and IDH1, IDH2, and TERT mutation status

https://doi.org/10.18632/oncotarget.19103

Chiara Pesenti, Leda Paganini, Laura Fontana, Emanuela Veniani, Letterio Runza, Stefano Ferrero, Silvano Bosari, Maura Menghi, Giovanni Marfia, Manuela Caroli, Rosamaria Silipigni, Silvana Guerneri, Silvia Tabano,  and Monica Miozzo
57134-57148
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Small molecular floribundiquinone B derived from medicinal plants inhibits acetylcholinesterase activity

Small molecular floribundiquinone B derived from medicinal plants inhibits acetylcholinesterase activity

https://doi.org/10.18632/oncotarget.19169

Bing Niu, Mengying Zhang, Pu Du, Li Jiang, Rui Qin, Qiang Su, Fuxue Chen, Dongshu Du, Yilai Shu,  and Kuo-Chen Chou
57149-57162
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Cbl-b predicts postoperative survival in patients with resectable pancreatic ductal adenocarcinoma

Cbl-b predicts postoperative survival in patients with resectable pancreatic ductal adenocarcinoma

https://doi.org/10.18632/oncotarget.18714

Qian Dong, Yuteng Ma, Yao Zhang, Xiujuan Qu, Zhi Li, Yafei Qi, Yunpeng Liu, Ce Li, Kai Li, Xianghong Yang,  and Xiaofang Che
57163-57173
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MiR-223-3p inhibits angiogenesis and promotes resistance to cetuximab in head and neck squamous cell carcinoma

MiR-223-3p inhibits angiogenesis and promotes resistance to cetuximab in head and neck squamous cell carcinoma

https://doi.org/10.18632/oncotarget.19170

Alexandre Bozec, Joséphine Zangari, Mathilde Butori-Pepino, Marius Ilie, Salomé Lalvee, Thierry Juhel, Catherine Butori, Patrick Brest, Paul Hofman,  and Valérie Vouret-Craviari
57174-57186
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Morusin inhibits cell proliferation and tumor growth by downregulating c-Myc in human gastric cancer

Morusin inhibits cell proliferation and tumor growth by downregulating c-Myc in human gastric cancer

https://doi.org/10.18632/oncotarget.19231

Feng Wang, Dunke Zhang, Jingxin Mao, Xiao-Xue Ke, Rui Zhang, Chao Yin, Ning Gao,  and Hongjuan Cui
57187-57200
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The ketogenic diet is not feasible as a therapy in a CD-1 nu/nu mouse model of renal cell carcinoma with features of Stauffer’s syndrome

The ketogenic diet is not feasible as a therapy in a CD-1 nu/nu mouse model of renal cell carcinoma with features of Stauffer’s syndrome

https://doi.org/10.18632/oncotarget.19306

Silvia Vidali, Sepideh Aminzadeh-Gohari, René Günther Feichtinger, Renaud Vatrinet, Andreas Koller, Felix Locker, Tricia Rutherford, Maura O’Donnell, Andrea Stöger-Kleiber, Bridget Lambert, Thomas Klaus Felder, Wolfgang Sperl,  and Barbara Kofler
57201-57215
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

ARD1-mediated aurora kinase A acetylation promotes cell proliferation and migration

ARD1-mediated aurora kinase A acetylation promotes cell proliferation and migration

https://doi.org/10.18632/oncotarget.19332

Tam Thuy Lu Vo, Ji-Hyeon Park, Ji Hae Seo, Eun Ji Lee, Hoon Choi, Sung-Jin Bae, Hoang Le, Sunho An, Hye Shin Lee, Hee-Jun Wee,  and Kyu-Won Kim
57216-57230
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Assessment of near-infrared fluorophores to study the biodistribution and tumor targeting of an IL13 receptor α2 antibody by fluorescence molecular tomography

Assessment of near-infrared fluorophores to study the biodistribution and tumor targeting of an IL13 receptor α2 antibody by fluorescence molecular tomography

https://doi.org/10.18632/oncotarget.19569

Parul Gupta, Jo-Ann Wentland, Mauricio Leal, Dangshe Ma, Rachel Roach, Antonio Esparza, Lindsay King, Mary E. Spilker, Cedo Bagi, Christopher T. Winkelmann,  and Anand Giddabasappa
57231-57245
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

NSC30049 inhibits Chk1 pathway in 5-FU-resistant CRC bulk and stem cell populations

NSC30049 inhibits Chk1 pathway in 5-FU-resistant CRC bulk and stem cell populations

https://doi.org/10.18632/oncotarget.19778

Satya Narayan, Aruna S. Jaiswal, Ritika Sharma, Akbar Nawab, Lizette Vila Duckworth, Brian K. Law, Maria Zajac-Kaye, Thomas J. George, Jay Sharma, Arun K. Sharma,  and Robert A. Hromas
57246-57264
Abstract  |  PDF  |  HTML  |  Order a Reprint

Folate metabolism genetic polymorphisms and meningioma and glioma susceptibility in adults

Folate metabolism genetic polymorphisms and meningioma and glioma susceptibility in adults

https://doi.org/10.18632/oncotarget.18986

Dongming Chen, Jun Dong, Ying Huang, Feng Gao, Xiaopeng Yang, Xianglun Gong, Xiaochen Lv, Chenghao Chu, Yonggang Wu,  and Yong Zheng
57265-57277
Abstract  |  PDF  |  HTML  |  Order a Reprint

Prostate cancer diagnosis using epigenetic biomarkers, 3D high-content imaging and probabilistic cell-by-cell classifiers

Prostate cancer diagnosis using epigenetic biomarkers, 3D high-content imaging and probabilistic cell-by-cell classifiers

https://doi.org/10.18632/oncotarget.18985

Darko Stefanovski, George Tang, Kolja Wawrowsky, Raymond C. Boston, Nils Lambrecht,  and Jian Tajbakhsh
57278-57301
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Integration of ALV into CTDSPL and CTDSPL2 genes in B-cell lymphomas promotes cell immortalization, migration and survival

Integration of ALV into CTDSPL and CTDSPL2 genes in B-cell lymphomas promotes cell immortalization, migration and survival

https://doi.org/10.18632/oncotarget.19328

Shelby Winans, Alyssa Flynn, Sanandan Malhotra, Vidya Balagopal,  and Karen L. Beemon
57302-57315
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Meta-Analysis

An updated meta-analysis of amantadine for treating dyskinesia in Parkinson’s disease

An updated meta-analysis of amantadine for treating dyskinesia in Parkinson’s disease

https://doi.org/10.18632/oncotarget.17622

Min Kong, Maowen Ba, Chao Ren, Ling Yu, Shengjie Dong, Guoping Yu,  and Hui Liang
57316-57326
Abstract  |  PDF  |  HTML  |  Order a Reprint

Prognositic value of CD73-adenosinergic pathway in solid tumor: A meta-analysis and systematic review

Prognositic value of CD73-adenosinergic pathway in solid tumor: A meta-analysis and systematic review

https://doi.org/10.18632/oncotarget.16905

Rong Wang, Yingying Zhang, Xia Lin, Yalin Gao,  and Ying Zhu
57327-57336
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Bevacizumab combined with chemotherapy for glioblastoma: a meta-analysis of randomized controlled trials

Bevacizumab combined with chemotherapy for glioblastoma: a meta-analysis of randomized controlled trials

https://doi.org/10.18632/oncotarget.16924

Shou-Bo Yang, Kai-Di Gao, Tao Jiang, Shu-Jun Cheng,  and Wen-Bin Li
57337-57344
Abstract  |  PDF  |  HTML  |  Order a Reprint

Association of apelin and apelin receptor with the risk of coronary artery disease: a meta-analysis of observational studies

Association of apelin and apelin receptor with the risk of coronary artery disease: a meta-analysis of observational studies

https://doi.org/10.18632/oncotarget.17360

Tianbao Chen, Bing Wu,  and Rong Lin
57345-57355
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Clinical outcomes of WBRT plus EGFR-TKIs versus WBRT or TKIs alone for the treatment of cerebral metastatic NSCLC patients: a meta-analysis

Clinical outcomes of WBRT plus EGFR-TKIs versus WBRT or TKIs alone for the treatment of cerebral metastatic NSCLC patients: a meta-analysis

https://doi.org/10.18632/oncotarget.19054

Hong Zheng, Quan-Xing Liu, Bin Hou, Dong Zhou, Jing-Meng Li, Xiao Lu, Qiu-Ping Wu,  and Ji-Gang Dai
57356-57364
Abstract  |  PDF  |  HTML  |  Order a Reprint

Docetaxel versus docetaxel plus cisplatin for non-small-cell lung cancer: a meta-analysis of randomized clinical trials

Docetaxel versus docetaxel plus cisplatin for non-small-cell lung cancer: a meta-analysis of randomized clinical trials

https://doi.org/10.18632/oncotarget.17071

Ang Li, Zhi-Jian Wei, Han Ding, Hao-Shuai Tang, Heng-Xing Zhou, Xue Yao,  and Shi-Qing Feng
57365-57378
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Meta-analysis of the incidence and risks of interstitial lung disease and QTc prolongation in non-small-cell lung cancer patients treated with ALK inhibitors

Meta-analysis of the incidence and risks of interstitial lung disease and QTc prolongation in non-small-cell lung cancer patients treated with ALK inhibitors

https://doi.org/10.18632/oncotarget.18283

Liping Lin, Juanjuan Zhao, Ning Kong, Yan He, Jiazhu Hu, Fuxi Huang, Jianjun Han,  and Xiaolong Cao
57379-57385
Abstract  |  PDF  |  HTML  |  Order a Reprint

Prognostic role of tumor-infiltrating lymphocytes in gastric cancer: a meta-analysis

Prognostic role of tumor-infiltrating lymphocytes in gastric cancer: a meta-analysis

https://doi.org/10.18632/oncotarget.18065

Xiao Zheng, Xing Song, Yingjie Shao, Bin Xu, Lujun Chen, Qi Zhou, Wenwei Hu, Dachuan Zhang, Changping Wu, Min Tao, Yibei Zhu,  and Jingting Jiang
57386-57398
Abstract  |  PDF  |  HTML  |  Order a Reprint

Combination therapy versus pharmacotherapy, endoscopic variceal ligation, or the transjugular intrahepatic portosystemic shunt alone in the secondary prevention of esophageal variceal bleeding: a meta-analysis of randomized controlled trials

Combination therapy versus pharmacotherapy, endoscopic variceal ligation, or the transjugular intrahepatic portosystemic shunt alone in the secondary prevention of esophageal variceal bleeding: a meta-analysis of randomized controlled trials

https://doi.org/10.18632/oncotarget.18143

Lu-Lu Lin, Shi-Ming Du, Yan Fu, Hui-Yun Gu, Lei Wang, Zhi-Yuan Jian, Xian-Feng Shen, Jie Luo,  and Chao Zhang
57399-57408
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Association of P73 polymorphisms with susceptibilities of cervical carcinoma: a meta-analysis

Association of P73 polymorphisms with susceptibilities of cervical carcinoma: a meta-analysis

https://doi.org/10.18632/oncotarget.18164

Xianghua Liang, Bingxiang Chen,  and Jianxin Zhong
57409-57413
Abstract  |  PDF  |  HTML  |  Order a Reprint

Systematic review and meta-analysis of the efficacy of breast conservation therapy followed by radiotherapy in four breast cancer subtypes

Systematic review and meta-analysis of the efficacy of breast conservation therapy followed by radiotherapy in four breast cancer subtypes

https://doi.org/10.18632/oncotarget.18205

Xin-Bin Pan, Rou-Jun Chen, Shi-Ting Huang, Yan-Ming Jiang,  and Xiao-Dong Zhu
57414-57420
Abstract  |  PDF  |  HTML  |  Order a Reprint

Association between 8q24 rs6983267 polymorphism and cancer susceptibility: a meta-analysis involving 170,737 subjects

Association between 8q24 rs6983267 polymorphism and cancer susceptibility: a meta-analysis involving 170,737 subjects

https://doi.org/10.18632/oncotarget.18960

Man Zhu, Xue Wen, Xuefang Liu, Yingchao Wang, Chunzi Liang,  and Jiancheng Tu
57421-57439
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Lack of association between NAT2 polymorphism and prostate cancer risk: a meta-analysis and trial sequential analysis

Lack of association between NAT2 polymorphism and prostate cancer risk: a meta-analysis and trial sequential analysis

https://doi.org/10.18632/oncotarget.19023

Feng Wang, Zhiqiang Qin, Shuhui Si, Jingyuan Tang, Lingyan Xu, Haoxiang Xu, Ran Li, Peng Han,  and Haiwei Yang
57440-57450
Abstract  |  PDF  |  HTML  |  Order a Reprint

Clinical Research Papers

BACH2 promotes indolent clinical presentation in Waldenström macroglobulinemia

BACH2 promotes indolent clinical presentation in Waldenström macroglobulinemia

https://doi.org/10.18632/oncotarget.9917

Charles Herbaux, Elisabeth Bertrand, Guillemette Marot, Christophe Roumier, Nicolas Poret, Valérie Soenen, Olivier Nibourel, Catherine Roche-Lestienne, Natacha Broucqsault, Sylvie Galiègue-Zouitina, Eileen M Boyle, Guillemette Fouquet, Aline Renneville, Sabine Tricot, Franck Morschhauser, Claude Preudhomme, Bruno Quesnel, Stephanie Poulain,  and Xavier Leleu
57451-57459
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Prognostic significance of neutrophil-to-lymphocyte ratio in patients with malignant pleural mesothelioma: a meta-analysis

Prognostic significance of neutrophil-to-lymphocyte ratio in patients with malignant pleural mesothelioma: a meta-analysis

https://doi.org/10.18632/oncotarget.15404

Nan Chen, Shuai Liu, Lin Huang, Wanling Li, Wenhao Yang, Tianxin Cong, Lin Ding,  and Meng Qiu
57460-57469
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Evaluation on efficacy and safety of the addition of X-knife therapy to gefitinib in NSCLC patients with symptomatic brain metastases

Evaluation on efficacy and safety of the addition of X-knife therapy to gefitinib in NSCLC patients with symptomatic brain metastases

https://doi.org/10.18632/oncotarget.10420

Linbo Cai, Xiaoguang Qiu, Haihong Yang, Mingyao Lai, Changguo Shan, Weiping Hong, Juan Li, Longhui Luo, Ping Zhang,  and Lichao Wang
57470-57476
Abstract  |  PDF  |  HTML  |  Order a Reprint

Features and risk factors of carotid atherosclerosis in a population with high stroke incidence in China

Features and risk factors of carotid atherosclerosis in a population with high stroke incidence in China

https://doi.org/10.18632/oncotarget.15415

Yanqiu Zhang, Lingling Bai, Min Shi, Hongyan Lu, Yanan Wu, Jun Tu, Jingxian Ni, Jinghua Wang, Li Cao, Ping Lei,  and Xianjia Ning
57477-57488
Abstract  |  PDF  |  HTML  |  Order a Reprint

Neutrophil-to-lymphocyte ratio and neurological deterioration following acute cerebral hemorrhage

Neutrophil-to-lymphocyte ratio and neurological deterioration following acute cerebral hemorrhage

https://doi.org/10.18632/oncotarget.15423

Simona Lattanzi, Claudia Cagnetti, Leandro Provinciali,  and Mauro Silvestrini
57489-57494
Abstract  |  PDF  |  HTML  |  Order a Reprint

Different long-term oncologic outcomes after radical surgical resection for neuroendocrine carcinoma and adenocarcinoma of the stomach

Different long-term oncologic outcomes after radical surgical resection for neuroendocrine carcinoma and adenocarcinoma of the stomach

https://doi.org/10.18632/oncotarget.15488

Jian-Wei Xie, Jun Lu, Jian-Xian Lin, Chao-Hui Zheng, Ping Li, Jia-Bin Wang, Qi-Yue Chen, Long-Long Cao, Mi Lin, Ru-Hong Tu,  and Chang-Ming Huang
57495-57504
Abstract  |  PDF  |  HTML  |  Order a Reprint

Efficacy and safety of a reduced calcineurin inhibitor dose combined with mycophenolate mofetil in liver transplant patients with chronic renal dysfunction

Efficacy and safety of a reduced calcineurin inhibitor dose combined with mycophenolate mofetil in liver transplant patients with chronic renal dysfunction

https://doi.org/10.18632/oncotarget.15490

Pusen Wang, Weitao Que, Hao Li, Lvnan Yan, Zhiren Fu, Qifa Ye, Guihua Chen, Kefeng Dou, Shichun Lu, Zhanyu Yang, Zhijun Zhu, Zhihai Peng,  and Lin Zhong
57505-57515
Abstract  |  PDF  |  HTML  |  Order a Reprint

Preoperative monocyte-lymphocyte and neutrophil-lymphocyte but not platelet-lymphocyte ratios are predictive of clinical outcomes in resected patients with non-metastatic Siewert type II/III adenocarcinoma of esophagogastric junction: a prospective cohort study (the AMONP corhort)

Preoperative monocyte-lymphocyte and neutrophil-lymphocyte but not platelet-lymphocyte ratios are predictive of clinical outcomes in resected patients with non-metastatic Siewert type II/III adenocarcinoma of esophagogastric junction: a prospective cohort study (the AMONP corhort)

https://doi.org/10.18632/oncotarget.15497

Jia-Wei Zhang, Lei Huang,  and A-Man Xu
57516-57527
Abstract  |  PDF  |  HTML  |  Order a Reprint

Biomarker analysis of the phase 3 TORCH trial for first line erlotinib versus chemotherapy in advanced non-small cell lung cancer patients

Biomarker analysis of the phase 3 TORCH trial for first line erlotinib versus chemotherapy in advanced non-small cell lung cancer patients

https://doi.org/10.18632/oncotarget.15725

Lucia Kim, Mauro Saieg, Massimo Di Maio, Ciro Gallo, Charles Butts, Fortunato Ciardiello, Ronald Feld, Dengxiao Cheng, Vittorio Gebbia, Marco Angelo Burgio, Yasmin Alam, Simona Signoriello, Antonio Rossi, Natasha Leighl, Paolo Maione, Alessandro Morabito, Geoffrey Liu, Ming-Sound Tsao, Francesco Perrone,  and Cesare Gridelli
57528-57536
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The application of IS6110-baced loop-mediated isothermal amplification (LAMP) in the early diagnosis of tuberculous meningitis

The application of IS6110-baced loop-mediated isothermal amplification (LAMP) in the early diagnosis of tuberculous meningitis

https://doi.org/10.18632/oncotarget.15734

Wen-Wen Sun, Qin Sun, Li-Ping Yan,  and Qing Zhang
57537-57542
Abstract  |  PDF  |  HTML  |  Order a Reprint

Association of pre-operative depressive and anxiety symptoms with five-year survival of glioma and meningioma patients: a prospective cohort study

Association of pre-operative depressive and anxiety symptoms with five-year survival of glioma and meningioma patients: a prospective cohort study

https://doi.org/10.18632/oncotarget.15743

Adomas Bunevicius, Vytenis Pranas Deltuva,  and Arimantas Tamasauskas
57543-57551
Abstract  |  PDF  |  HTML  |  Order a Reprint

Evaluation of intracavitary administration of curcumin for the treatment of sarcomatoid mesothelioma

Evaluation of intracavitary administration of curcumin for the treatment of sarcomatoid mesothelioma

https://doi.org/10.18632/oncotarget.15744

Daniel L. Pouliquen, Béatrice Nawrocki-Raby, Joëlle Nader, Stéphanie Blandin, Myriam Robard, Philippe Birembaut,  and Marc Grégoire
57552-57573
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

TOP2A, GGH, and PECAM1 are associated with hematogenous, lymph node, and peritoneal recurrence in stage II/III gastric cancer patients enrolled in the ACTS-GC study

TOP2A, GGH, and PECAM1 are associated with hematogenous, lymph node, and peritoneal recurrence in stage II/III gastric cancer patients enrolled in the ACTS-GC study

https://doi.org/10.18632/oncotarget.15895

Masanori Terashima, Wataru Ichikawa, Atsushi Ochiai, Koji Kitada, Issei Kurahashi, Shinichi Sakuramoto, Hitoshi Katai, Takeshi Sano, Hiroshi Imamura, Mitsuru Sasako,  and for the ACTS-GC Group
57574-57582
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Preoperative assessment of mitral valve abnormalities in left atrial myxoma patients using cardiac CT

Preoperative assessment of mitral valve abnormalities in left atrial myxoma patients using cardiac CT

https://doi.org/10.18632/oncotarget.16139

Jing Chen, Zhi-Gang Yang, En-Sen Ma, Qin Zhang, Xi Liu,  and Ying-Kun Guo
57583-57593
Abstract  |  PDF  |  HTML  |  Order a Reprint

Risk of aortic aneurysm and dissection in patients with autosomal-dominant polycystic kidney disease: a nationwide population-based cohort study

Risk of aortic aneurysm and dissection in patients with autosomal-dominant polycystic kidney disease: a nationwide population-based cohort study

https://doi.org/10.18632/oncotarget.16338

Pei-Hsun Sung, Yao-Hsu Yang, Hsin-Ju Chiang, John Y. Chiang, Chi-Jen Chen, Chien-Ting Liu, Cheuk-Man Yu,  and Hon-Kan Yip
57594-57604
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Reviews

Biological effects and epidemiological consequences of arsenic exposure, and reagents that can ameliorate arsenic damage in vivo

Biological effects and epidemiological consequences of arsenic exposure, and reagents that can ameliorate arsenic damage in vivo

https://doi.org/10.18632/oncotarget.17745

Chinthalapally V. Rao, Sanya Pal, Altaf Mohammed, Mudassir Farooqui, Mark P. Doescher, Adam S. Asch,  and Hiroshi Y. Yamada
57605-57621
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The fat and the bad: Mature adipocytes, key actors in tumor progression and resistance

The fat and the bad: Mature adipocytes, key actors in tumor progression and resistance

https://doi.org/10.18632/oncotarget.18038

Minh Ngoc Duong, Aline Geneste, Frederique Fallone, Xia Li, Charles Dumontet,  and Catherine Muller
57622-57641
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Comparison among fertility-sparing therapies for well differentiated early-stage endometrial carcinoma and complex atypical hyperplasia

Comparison among fertility-sparing therapies for well differentiated early-stage endometrial carcinoma and complex atypical hyperplasia

https://doi.org/10.18632/oncotarget.17588

Qing Zhang, Gonghua Qi, Margaux J. Kanis, Ruifen Dong, Baoxia Cui, Xingsheng Yang,  and Beihua Kong
57642-57653
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Targeted therapies for gastric cancer: failures and hopes from clinical trials

Targeted therapies for gastric cancer: failures and hopes from clinical trials

https://doi.org/10.18632/oncotarget.14825

Maria Apicella, Simona Corso,  and Silvia Giordano
57654-57669
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Treatments of traumatic neuropathic pain: a systematic review

Treatments of traumatic neuropathic pain: a systematic review

https://doi.org/10.18632/oncotarget.16917

Chenglun Yao, Xijie Zhou, Bin Zhao, Chao Sun, Keshav Poonit,  and Hede Yan
57670-57679
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Driver genes in non-small cell lung cancer: Characteristics, detection methods, and targeted therapies

Driver genes in non-small cell lung cancer: Characteristics, detection methods, and targeted therapies

https://doi.org/10.18632/oncotarget.17016

Qing-Ge Zhu, Shi-Ming Zhang, Xiao-Xiao Ding, Bing He,  and Hu-Qin Zhang
57680-57692
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Promising landscape for regulating macrophage polarization: epigenetic viewpoint

Promising landscape for regulating macrophage polarization: epigenetic viewpoint

https://doi.org/10.18632/oncotarget.17027

Dexi Zhou, Kui Yang, Lu Chen, Wen Zhang, Zhenyu Xu, Jian Zuo, Hui Jiang,  and Jiajie Luan
57693-57706
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The role of autophagy in hepatocellular carcinoma: friend or foe

The role of autophagy in hepatocellular carcinoma: friend or foe

https://doi.org/10.18632/oncotarget.17202

Lian Liu, Jia-Zhi Liao, Xing-Xing He,  and Pei-Yuan Li
57707-57722
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Augmented expression of polo-like kinase 1 indicates poor clinical outcome for breast patients: a systematic review and meta-analysis

Augmented expression of polo-like kinase 1 indicates poor clinical outcome for breast patients: a systematic review and meta-analysis

https://doi.org/10.18632/oncotarget.17301

Yunfeng Zhang, Zhibin Wu, Dapeng Liu, Meng Wang, Guodong Xiao, Peili Wang, Xin Sun, Hong Ren, Shou-Ching Tang,  and Ning Du
57723-57732
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Targeting metabolism and AMP-activated kinase with metformin to sensitize non-small cell lung cancer (NSCLC) to cytotoxic therapy: translational biology and rationale for current clinical trials

Targeting metabolism and AMP-activated kinase with metformin to sensitize non-small cell lung cancer (NSCLC) to cytotoxic therapy: translational biology and rationale for current clinical trials

https://doi.org/10.18632/oncotarget.17496

Michael Troncone, Stephanie M. Cargnelli, Linda A. Villani, Naghmeh Isfahanian, Lindsay A. Broadfield, Laura Zychla, Jim Wright, Gregory Pond, Gregory R. Steinberg,  and Theodoros Tsakiridis
57733-57754
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The prognostic value of long noncoding RNAs in prostate cancer: a systematic review and meta-analysis

The prognostic value of long noncoding RNAs in prostate cancer: a systematic review and meta-analysis

https://doi.org/10.18632/oncotarget.17645

Weijie Ma, Xi Chen, Lu Ding, Jianhong Ma, Wei Jing, Tian Lan, Haseeb Sattar, Yongchang Wei, Fuling Zhou,  and Yufeng Yuan
57755-57765
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Insights from animal models of bladder cancer: recent advances, challenges, and opportunities

Insights from animal models of bladder cancer: recent advances, challenges, and opportunities

https://doi.org/10.18632/oncotarget.17714

Bincy Anu John,  and Neveen Said
57766-57781
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Vitamin K and its analogs: Potential avenues for prostate cancer management

Vitamin K and its analogs: Potential avenues for prostate cancer management

https://doi.org/10.18632/oncotarget.17997

Subramanyam Dasari, Syed M. Ali, Guoxing Zheng, Aoshuang Chen, Venkata Satish Dontaraju, Maarten C. Bosland, Andre Kajdacsy-Balla,  and Gnanasekar Munirathinam
57782-57799
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Formation, function, and exhaustion of notochordal cytoplasmic vacuoles within intervertebral disc: current understanding and speculation

Formation, function, and exhaustion of notochordal cytoplasmic vacuoles within intervertebral disc: current understanding and speculation

https://doi.org/10.18632/oncotarget.18101

Feng Wang, Zeng-Xin Gao, Feng Cai, Arjun Sinkemani, Zhi-Yang Xie, Rui Shi, Ji-Nan Wei,  and Xiao-Tao Wu
57800-57812
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The reverse Warburg effect is likely to be an Achilles’ heel of cancer that can be exploited for cancer therapy

The reverse Warburg effect is likely to be an Achilles’ heel of cancer that can be exploited for cancer therapy

https://doi.org/10.18632/oncotarget.18175

Yaojie Fu, Shanshan Liu, Shanghelin Yin, Weihong Niu, Wei Xiong, Ming Tan, Guiyuan Li,  and Ming Zhou
57813-57825
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The efficacy of anti-PD-1/PD-L1 therapy and its comparison with EGFR-TKIs for advanced non-small-cell lung cancer

The efficacy of anti-PD-1/PD-L1 therapy and its comparison with EGFR-TKIs for advanced non-small-cell lung cancer

https://doi.org/10.18632/oncotarget.18406

Zhixin Sheng, Xu Zhu, Yanhua Sun,  and Yanxia Zhang
57826-57835
Abstract  |  PDF  |  HTML  |  Order a Reprint

Epigenetic regulation during the differentiation of stem cells to germ cells

Epigenetic regulation during the differentiation of stem cells to germ cells

https://doi.org/10.18632/oncotarget.18444

Yuan-Chao Sun, Yong-Yong Wang, Wei Ge, Shun-Feng Cheng, Paul W. Dyce,  and Wei Shen
57836-57844
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Implementation and utilization of the molecular tumor board to guide precision medicine

Implementation and utilization of the molecular tumor board to guide precision medicine

https://doi.org/10.18632/oncotarget.18471

Shuko Harada, Rebecca Arend, Qian Dai, Jessica A. Levesque, Thomas S. Winokur, Rongjun Guo, Martin J. Heslin, Lisle Nabell, L. Burt Nabors, Nita A. Limdi, Kevin A. Roth, Edward E. Partridge, Gene P. Siegal,  and Eddy S. Yang
57845-57854
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p53, p63 and p73 in the wonderland of S. cerevisiae

p53, p63 and p73 in the wonderland of S. cerevisiae

https://doi.org/10.18632/oncotarget.18506

Olivier Billant, Marc Blondel,  and Cécile Voisset
57855-57869
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The PI3K/Akt pathway: a critical player in intervertebral disc degeneration

The PI3K/Akt pathway: a critical player in intervertebral disc degeneration

https://doi.org/10.18632/oncotarget.18628

Zhi-Hua Ouyang, Wen-Jun Wang, Yi-Guo Yan, Bin Wang,  and Guo-Hua Lv
57870-57881
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Case Reports

Genomic analysis of exceptional responder to regorafenib in treatment-refractory metastatic rectal cancer: a case report and review of the literature

Genomic analysis of exceptional responder to regorafenib in treatment-refractory metastatic rectal cancer: a case report and review of the literature

https://doi.org/10.18632/oncotarget.18357

Krittiya Korphaisarn, Jonathan M. Loree, Van Nguyen, Ryanne Coulson, Vijaykumar Holla, Beate C. Litzenburger, Ken Chen, Gordon B. Mills, Dipen M. Maru, Funda Meric-Bernstan, Kenna R. Mills Shaw,  and Scott Kopetz
57882-57888
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Pseudoprogression in microsatellite instability-high colorectal cancer during treatment with combination T cell mediated immunotherapy: a case report and literature review

Pseudoprogression in microsatellite instability-high colorectal cancer during treatment with combination T cell mediated immunotherapy: a case report and literature review

https://doi.org/10.18632/oncotarget.18361

Young Kwang Chae, Si Wang, Halla Nimeiri, Aparna Kalyan,  and Francis J. Giles
57889-57897
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Dramatic response of CTNNB1 and VEGFR-2 mutant temporal bone squamous cell carcinoma to bevacizumab in combination with pemetrexed

Dramatic response of CTNNB1 and VEGFR-2 mutant temporal bone squamous cell carcinoma to bevacizumab in combination with pemetrexed

https://doi.org/10.18632/oncotarget.19649

Lai Wei, Lizhi Wang, Ziye Liu, Meiyi Wang, Weili Lu, Dewei Zhao, Bin Yang, Xuejun Kong, Yan Ding,  and Zhiqiang Wang
57898-57904
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Corrections

Correction: A novel highly potent trivalent TGF-β receptor trap inhibits early-stage tumorigenesis and tumor cell invasion in murine Pten-deficient prostate glands

Correction: A novel highly potent trivalent TGF-β receptor trap inhibits early-stage tumorigenesis and tumor cell invasion in murine Pten-deficient prostate glands

https://doi.org/10.18632/oncotarget.20370

Tai Qin, Lindsey Barron, Lu Xia, Haojie Huang, Maria M. Villarreal, John Zwaagstra, Cathy Collins, Junhua Yang, Christian Zwieb, Ravindra Kodali, Cynthia S. Hinck, Sun Kyung Kim, Robert L. Reddick, Chang Shu, Maureen D. O’Connor-McCourt, Andrew P. Hinck,  and Lu-Zhe Sun
57905-57905
Correction  |  PDF

Correction: Increased autophagy in fibroblast-like synoviocytes leads to immune enhancement potential in rheumatoid arthritis

Correction: Increased autophagy in fibroblast-like synoviocytes leads to immune enhancement potential in rheumatoid arthritis

https://doi.org/10.18632/oncotarget.20371

Ru Yang, Yingzi Zhang, Lin Wang, Ji Hu, Jian Wen, Leixi Xue, Mei Tang, Zhichun Liu,  and Jinxiang Fu
57906-57906
Correction  |  PDF

Research Papers

C1orf64 is a novel androgen receptor target gene and coregulator that interacts with 14-3-3 protein in breast cancer

C1orf64 is a novel androgen receptor target gene and coregulator that interacts with 14-3-3 protein in breast cancer

https://doi.org/10.18632/oncotarget.17826

Ali Naderi
57907-57933
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint


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