Oncotarget

Vol 8, No 9

February 28, 2017

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About The Cover

The cover for issue 9 of Oncotarget features 'Tubulin-binding activity of chalcones,' from Canela, et al.

Table of Contents

News

CDK8: a new breast cancer target

CDK8: a new breast cancer target

https://doi.org/10.18632/oncotarget.15354

John Crown
14269-14270
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ATM/MAPK7 crosstalk in cancer

ATM/MAPK7 crosstalk in cancer

https://doi.org/10.18632/oncotarget.15367

José Yélamos
14271-14272
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Editorial

Boosting brain glucose metabolism to fight neurodegeneration?

Boosting brain glucose metabolism to fight neurodegeneration?

https://doi.org/10.18632/oncotarget.15131

María L. de Ceballos,  and Attila Köfalvi
14273-14274
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Cancer suppression by systemic inactivation of p38MAPK

Cancer suppression by systemic inactivation of p38MAPK

https://doi.org/10.18632/oncotarget.15293

Anna Brichkina,  and Dmitry V. Bulavin
14275-14276
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Editorial: Autophagy and Cell Death

Autophagy controls centrosome number

Autophagy controls centrosome number

https://doi.org/10.18632/oncotarget.15362

Shinya Honda,  and Shigeomi Shimizu
14277-14278
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Editorial: Neuroscience

Toward precision medicine in myotonic syndromes

Toward precision medicine in myotonic syndromes

https://doi.org/10.18632/oncotarget.15263

Michela De Bellis, Diana Conte Camerino,  and Jean-François Desaphy
14279-14280
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Dimethyl fumarate for ischemic stroke

Dimethyl fumarate for ischemic stroke

https://doi.org/10.18632/oncotarget.15357

Reiner Kunze
14281-14282
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Research Papers: Pathology

Melatonin attenuates angiotensin II-induced abdominal aortic aneurysm through the down-regulation of matrix metalloproteinases

Melatonin attenuates angiotensin II-induced abdominal aortic aneurysm through the down-regulation of matrix metalloproteinases

https://doi.org/10.18632/oncotarget.15093

Jing Kong, Ya Zhang, Shanshan Liu, Hongxuan Li, Shangming Liu, Jingjing Wang, Xiaoteng Qin, Xiuxin Jiang, Jianmin Yang, Cheng Zhang,  and Wencheng Zhang
14283-14293
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Pravastatin activates activator protein 2 alpha to augment the angiotensin II-induced abdominal aortic aneurysms

Pravastatin activates activator protein 2 alpha to augment the angiotensin II-induced abdominal aortic aneurysms

https://doi.org/10.18632/oncotarget.15104

Hui Ma, Wen-Jing Liang, Mei-Rong Shan, Xue-Qing Wang, Sheng-Nan Zhou, Yuan Chen, Tao Guo, Peng Li, Hai-Ya Yu, Chao Liu, Ya-Ling Yin, Yu-Lin Wang, Bo Dong, Xin-Yan Pang,  and Shuang-Xi Wang
14294-14305
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Research Papers: Immunology

Autoantibody to MDM2: A potential serological marker of primary Sjogren’s syndrome

Autoantibody to MDM2: A potential serological marker of primary Sjogren’s syndrome

https://doi.org/10.18632/oncotarget.14882

Yuan Liu, Xining Liao, Ying Wang, Shiju Chen, Yuechi Sun, Qingyan Lin,  and Guixiu Shi
14306-14313
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Neutralization of interleukin-9 ameliorates symptoms of allergic rhinitis by reducing Th2, Th9, and Th17 responses and increasing the Treg response in a murine model

Neutralization of interleukin-9 ameliorates symptoms of allergic rhinitis by reducing Th2, Th9, and Th17 responses and increasing the Treg response in a murine model

https://doi.org/10.18632/oncotarget.15177

Zhao Wei Gu, Yun Xiu Wang,  and Zhi Wei Cao
14314-14324
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Research Papers

Antivascular and antitumor properties of the tubulin-binding chalcone TUB091

Antivascular and antitumor properties of the tubulin-binding chalcone TUB091

https://doi.org/10.18632/oncotarget.9527

María-Dolores Canela, Sam Noppen, Oskía Bueno, Andrea E. Prota, Katja Bargsten, Gonzalo Sáez-Calvo, María-Luisa Jimeno, Mohammed Benkheil, Domenico Ribatti, Sonsoles Velázquez, María-José Camarasa, J. Fernando Díaz, Michel O. Steinmetz, Eva-María Priego, María-Jesús Pérez-Pérez,  and Sandra Liekens
14325-14342
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Epithelial membrane protein 3 regulates TGF-β signaling activation in CD44-high glioblastoma

Epithelial membrane protein 3 regulates TGF-β signaling activation in CD44-high glioblastoma

https://doi.org/10.18632/oncotarget.11102

Fu Jun, Jidong Hong, Qin Liu, Yong Guo, Yiwei Liao, Jianghai Huang, Sailan Wen,  and Liangfang Shen
14343-14358
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Musashi2 promotes the development and progression of pancreatic cancer by down-regulating Numb protein

Musashi2 promotes the development and progression of pancreatic cancer by down-regulating Numb protein

https://doi.org/10.18632/oncotarget.8736

Weiwei Sheng, Ming Dong, Chuanping Chen, Yang Li, Qingfeng Liu,  and Qi Dong
14359-14373
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Probing the prostate tumour microenvironment I: impact of glucose deprivation on a cell model of prostate cancer progression

Probing the prostate tumour microenvironment I: impact of glucose deprivation on a cell model of prostate cancer progression

https://doi.org/10.18632/oncotarget.14605

Claire Tonry, John Armstrong,  and Stephen R. Pennington
14374-14394
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Detection of phosphatidylserine-positive exosomes as a diagnostic marker for ovarian malignancies: a proof of concept study

Detection of phosphatidylserine-positive exosomes as a diagnostic marker for ovarian malignancies: a proof of concept study

https://doi.org/10.18632/oncotarget.14795

Jayanthi Lea, Raghava Sharma, Fan Yang, Hong Zhu, E. Sally Ward,  and Alan J. Schroit
14395-14407
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Prognostic value of the neutrophil-to-lymphocyte ratio in the ARQ 197-215 second-line study for advanced hepatocellular carcinoma

Prognostic value of the neutrophil-to-lymphocyte ratio in the ARQ 197-215 second-line study for advanced hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.14797

Nicola Personeni, Laura Giordano, Giovanni Abbadessa, Camillo Porta, Ivan Borbath, Bruno Daniele, Jean-Luc Van Laethem, Hans Van Vlierberghe, Jörg Trojan, Enrico N. De Toni, Antonio Gasbarrini, Monica Lencioni, Maria E. Lamar, Yunxia Wang, Dale Shuster, Brian Schwartz, Armando Santoro,  and Lorenza Rimassa
14408-14415
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Distinct patterns of infiltrating CD8+ T cells in HPV+ and CD68 macrophages in HPV- oropharyngeal squamous cell carcinomas are associated with better clinical outcome but PD-L1 expression is not prognostic

Distinct patterns of infiltrating CD8+ T cells in HPV+ and CD68 macrophages in HPV- oropharyngeal squamous cell carcinomas are associated with better clinical outcome but PD-L1 expression is not prognostic

https://doi.org/10.18632/oncotarget.14796

Kenneth Oguejiofor, Henry Galletta-Williams, Simon J. Dovedi, Darren L. Roberts, Peter L. Stern,  and Catharine M.L. West
14416-14427
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Ladarixin, a dual CXCR1/2 inhibitor, attenuates experimental melanomas harboring different molecular defects by affecting malignant cells and tumor microenvironment

Ladarixin, a dual CXCR1/2 inhibitor, attenuates experimental melanomas harboring different molecular defects by affecting malignant cells and tumor microenvironment

https://doi.org/10.18632/oncotarget.14803

Daria Marley Kemp, Alyson Pidich, Mary Larijani, Rebecca Jonas, Elizabeth Lash, Takami Sato, Mizue Terai, Maria De Pizzol, Marcello Allegretti, Olga Igoucheva,  and Vitali Alexeev
14428-14442
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Nuclear transport of cancer extracellular vesicle-derived biomaterials through nuclear envelope invagination-associated late endosomes

Nuclear transport of cancer extracellular vesicle-derived biomaterials through nuclear envelope invagination-associated late endosomes

https://doi.org/10.18632/oncotarget.14804

Germana Rappa, Mark F. Santos, Toni M. Green, Jana Karbanová, Justin Hassler, Yongsheng Bai, Sanford H. Barsky, Denis Corbeil,  and Aurelio Lorico
14443-14461
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The ribosomal protein gene RPL5 is a haploinsufficient tumor suppressor in multiple cancer types

The ribosomal protein gene RPL5 is a haploinsufficient tumor suppressor in multiple cancer types

https://doi.org/10.18632/oncotarget.14895

Laura Fancello, Kim R. Kampen, Isabel J.F. Hofman, Jelle Verbeeck,  and Kim De Keersmaecker
14462-14478
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Long non-coding RNA SPRY4-IT1 pormotes colorectal cancer metastasis by regulate epithelial-mesenchymal transition

Long non-coding RNA SPRY4-IT1 pormotes colorectal cancer metastasis by regulate epithelial-mesenchymal transition

https://doi.org/10.18632/oncotarget.10407

Fei Shen, Wen-Song Cai, Zhe Feng, Ji-wei Chen, Jian-hua Feng, Qi-cai Liu, Yong-ping Fang, Kun-ping Li, Huan-qing Xiao, Jie Cao,  and Bo Xu
14479-14486
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IκB-Kinase-epsilon (IKKε) over-expression promotes the growth of prostate cancer through the C/EBP-β dependent activation of IL-6 gene expression

IκB-Kinase-epsilon (IKKε) over-expression promotes the growth of prostate cancer through the C/EBP-β dependent activation of IL-6 gene expression

https://doi.org/10.18632/oncotarget.11629

Benjamin Péant, Sophie Gilbert, Cécile Le Page, Alexis Poisson, Emilie L’Ecuyer, Zied Boudhraa, Marc Nicolas Bienz, Nathalie Delvoye, Fred Saad,  and Anne-Marie Mes-Masson
14487-14501
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KLK6 proteolysis is implicated in the turnover and uptake of extracellular alpha-synuclein species

KLK6 proteolysis is implicated in the turnover and uptake of extracellular alpha-synuclein species

https://doi.org/10.18632/oncotarget.13264

Georgios Pampalakis, Vasia-Samantha Sykioti, Methodios Ximerakis, Ioanna Stefanakou-Kalakou, Ronald Melki, Kostas Vekrellis,  and Georgia Sotiropoulou
14502-14515
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Impact of diabetes on the risk of bedsore in patients undergoing surgery: an updated quantitative analysis of cohort studies

Impact of diabetes on the risk of bedsore in patients undergoing surgery: an updated quantitative analysis of cohort studies

https://doi.org/10.18632/oncotarget.14312

Mining Liang, Qiongni Chen, Yang Zhang, Li He, Jianjian Wang, Yiwen Cai,  and Lezhi Li
14516-14524
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Loss of maternal chromosome 11 is a signature event in SDHAF2, SDHD, and VHL-related paragangliomas, but less significant in SDHB-related paragangliomas

Loss of maternal chromosome 11 is a signature event in SDHAF2, SDHD, and VHL-related paragangliomas, but less significant in SDHB-related paragangliomas

https://doi.org/10.18632/oncotarget.14649

Attje S. Hoekstra, Erik F. Hensen, Ekaterina S. Jordanova, Esther Korpershoek, Anouk N.A. van der Horst-Schrivers, Cees Cornelisse, Eleonora P.M. Corssmit, Frederik J. Hes, Jeroen C. Jansen, Henricus P.M. Kunst, Henri J.L.M. Timmers, Adrian Bateman, Diana Eccles, Judith V.M.G. Bovée, Peter Devilee,  and Jean-Pierre Bayley
14525-14536
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Transcription factor HBP1 is a direct anti-cancer target of transcription factor FOXO1 in invasive oral cancer

Transcription factor HBP1 is a direct anti-cancer target of transcription factor FOXO1 in invasive oral cancer

https://doi.org/10.18632/oncotarget.14653

Chien-Yi Chan, Shih-Yi Huang, Jim Jinn-Chyuan Sheu, Mendel M. Roth, I-Tai Chou, Chia-Hsien Lien, Ming-Fen Lee,  and Chun-Yin Huang
14537-14548
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Tianfoshen oral liquid: a CFDA approved clinical traditional Chinese medicine, normalizes major cellular pathways disordered during colorectal carcinogenesis

Tianfoshen oral liquid: a CFDA approved clinical traditional Chinese medicine, normalizes major cellular pathways disordered during colorectal carcinogenesis

https://doi.org/10.18632/oncotarget.14675

Siliang Wang, Hengbin Wang,  and Yin Lu
14549-14569
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Increased incidence of ectopic pregnancy after in vitro fertilization in women with decreased ovarian reserve

Increased incidence of ectopic pregnancy after in vitro fertilization in women with decreased ovarian reserve

https://doi.org/10.18632/oncotarget.14679

Shengli Lin, Rui Yang, Hongbin Chi, Ying Lian, Jiejing Wang, Shuo Huang, Cuiling Lu, Ping Liu,  and Jie Qiao
14570-14575
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Transdifferentiation of human male germline stem cells to hepatocytes in vivo via the transplantation under renal capsules

Transdifferentiation of human male germline stem cells to hepatocytes in vivo via the transplantation under renal capsules

https://doi.org/10.18632/oncotarget.14713

Zheng Chen, Minghui Niu, Min Sun, Qingqing Yuan, Chencheng Yao, Jingmei Hou, Hong Wang, Liping Wen, Hongyong Fu, Fan Zhou, Zheng Li,  and Zuping He
14576-14592
Abstract  |  PDF  |  HTML  |  Order a Reprint

Tolfenamic acid-induced alterations in genes and pathways in pancreatic cancer cells

Tolfenamic acid-induced alterations in genes and pathways in pancreatic cancer cells

https://doi.org/10.18632/oncotarget.14651

Umesh T. Sankpal, Steve Goodison, Michelle Jones-Pauley, Myrna Hurtado, Fan Zhang,  and Riyaz Basha
14593-14603
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Inactivation of CK1α in multiple myeloma empowers drug cytotoxicity by affecting AKT and β-catenin survival signaling pathways

Inactivation of CK1α in multiple myeloma empowers drug cytotoxicity by affecting AKT and β-catenin survival signaling pathways

https://doi.org/10.18632/oncotarget.14654

Sabrina Manni, Marilena Carrino, Martina Manzoni, Ketty Gianesin, Sara Canovas Nunes, Matteo Costacurta, Laura Quotti Tubi, Paolo Macaccaro, Elisa Taiana, Anna Cabrelle, Gregorio Barilà, Annalisa Martines, Renato Zambello, Laura Bonaldi, Livio Trentin, Antonino Neri, Gianpietro Semenzato,  and Francesco Piazza
14604-14619
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Genomic characteristics of pancreatic squamous cell carcinoma, an investigation by using high throughput sequencing after in-solution hybrid capture

Genomic characteristics of pancreatic squamous cell carcinoma, an investigation by using high throughput sequencing after in-solution hybrid capture

https://doi.org/10.18632/oncotarget.14678

Meng-Dan Xu, Shu-Ling Liu, Yi-Zhong Feng, Qiang Liu, Meng Shen, Qiaoming Zhi, Zeyi Liu, Dong-Mei Gu, Jie Yu, Liu-Mei Shou, Fei-Ran Gong, Qi Zhu, Weiming Duan, Kai Chen, Junning Zhang, Meng-Yao Wu, Min Tao,  and Wei Li
14620-14635
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The association of two polymorphisms in adiponectin-encoding gene with hypertension risk and the changes of circulating adiponectin and blood pressure: A meta-analysis

The association of two polymorphisms in adiponectin-encoding gene with hypertension risk and the changes of circulating adiponectin and blood pressure: A meta-analysis

https://doi.org/10.18632/oncotarget.14680

Jianmin Wu, Guoyan Xu, Wenqin Cai, Yun Huang, Ningyu Xie, Yihua Shen,  and Liangdi Xie
14636-14645
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Allergies and risk of colorectal cancer: a systematic review and meta-analysis of observational studies

Allergies and risk of colorectal cancer: a systematic review and meta-analysis of observational studies

https://doi.org/10.18632/oncotarget.14599

Jianrong Ye, Ailaiti Talaiti, Yan Ma, Qin Zhang, Long Ma,  and Hong Zheng
14646-14654
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Chemotherapy-mediated miR-29b expression inhibits the invasion and angiogenesis of cervical cancer

Chemotherapy-mediated miR-29b expression inhibits the invasion and angiogenesis of cervical cancer

https://doi.org/10.18632/oncotarget.14738

Yunyun Li, Zhongzu Zhang, Zhenghua Xiao, Ying Lin, Tangshu Luo, Qin Zhou,  and Xiaojing Zhang
14655-14665
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Valproic acid inhibits glioblastoma multiforme cell growth via paraoxonase 2 expression

Valproic acid inhibits glioblastoma multiforme cell growth via paraoxonase 2 expression

https://doi.org/10.18632/oncotarget.14716

Jen-Ho Tseng, Cheng-Yi Chen, Pei-Chun Chen, Sheng-Huang Hsiao, Chi-Chen Fan, Yu-Chih Liang,  and Chie-Pein Chen
14666-14679
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Cytoprotective effect of chlorogenic acid against hydrogen peroxide-induced oxidative stress in MC3T3-E1 cells through PI3K/Akt-mediated Nrf2/HO-1 signaling pathway

Cytoprotective effect of chlorogenic acid against hydrogen peroxide-induced oxidative stress in MC3T3-E1 cells through PI3K/Akt-mediated Nrf2/HO-1 signaling pathway

https://doi.org/10.18632/oncotarget.14747

Dandan Han, Wei Chen, Xiaolong Gu, Ruixue Shan, Jiaqi Zou, Gang Liu, Muhammad Shahid, Jian Gao,  and Bo Han
14680-14692
Abstract  |  PDF  |  HTML  |  Order a Reprint

MicroRNA-744 promotes prostate cancer progression through aberrantly activating Wnt/β-catenin signaling

MicroRNA-744 promotes prostate cancer progression through aberrantly activating Wnt/β-catenin signaling

https://doi.org/10.18632/oncotarget.14711

Han Guan, Chunhui Liu, Fang Fang, Yeqing Huang, Tao Tao, Zhixin Ling, Zonghao You, Xu Han, Shuqiu Chen, Bin Xu,  and Ming Chen
14693-14707
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Transcriptional suppression of microRNA-27a contributes to laryngeal cancer differentiation via GSK-3β-involved Wnt/β-catenin pathway

Transcriptional suppression of microRNA-27a contributes to laryngeal cancer differentiation via GSK-3β-involved Wnt/β-catenin pathway

https://doi.org/10.18632/oncotarget.14769

Sheng Chen, Yuan-Yuan Sun, Zhao-Xiong Zhang, Yun-Hui Li, Zhen-Ming Xu,  and Wei-Neng Fu
14708-14718
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MAGE expression in head and neck squamous cell carcinoma primary tumors, lymph node metastases and respective recurrences-implications for immunotherapy

MAGE expression in head and neck squamous cell carcinoma primary tumors, lymph node metastases and respective recurrences-implications for immunotherapy

https://doi.org/10.18632/oncotarget.14830

Simon Laban, Gregor Giebel, Niklas Klümper, Andreas Schröck, Johannes Doescher, Giulio Spagnoli, Julia Thierauf, Marie-Nicole Theodoraki, Romain Remark, Sacha Gnjatic, Rosemarie Krupar, Andrew G. Sikora, Geert Litjens, Niels Grabe, Glen Kristiansen, Friedrich Bootz, Patrick J. Schuler, Cornelia Brunner, Johannes Brägelmann, Thomas K. Hoffmann,  and Sven Perner
14719-14735
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

AMPK-autophagy inhibition sensitizes icaritin-induced anti-colorectal cancer cell activity

AMPK-autophagy inhibition sensitizes icaritin-induced anti-colorectal cancer cell activity

https://doi.org/10.18632/oncotarget.14718

Chunxian Zhou, Jun Gu, Gang Zhang, Da Dong, Qunying Yang, Min-Bin Chen,  and Dongfeng Xu
14736-14747
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A new HDAC inhibitor cinnamoylphenazine shows antitumor activity in association with intensive macropinocytosis

A new HDAC inhibitor cinnamoylphenazine shows antitumor activity in association with intensive macropinocytosis

https://doi.org/10.18632/oncotarget.14714

Bing-yan Zhu, Bo-yang Shang, Yue Du, Yi Li, Liang Li, Xian-dong Xu,  and Yong-su Zhen
14748-14758
Abstract  |  PDF  |  HTML  |  Order a Reprint

Clinicopathological significance of intratumoral and peritumoral lymphocytes and lymphocyte score based on the histologic subtypes of cutaneous melanoma

Clinicopathological significance of intratumoral and peritumoral lymphocytes and lymphocyte score based on the histologic subtypes of cutaneous melanoma

https://doi.org/10.18632/oncotarget.14736

Cheol Keun Park,  and Sang Kyum Kim
14759-14769
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Matched-pair analysis of survival in patients with poorly differentiated versus well-differentiated glottic squamous cell carcinoma

Matched-pair analysis of survival in patients with poorly differentiated versus well-differentiated glottic squamous cell carcinoma

https://doi.org/10.18632/oncotarget.14772

Ping Chen, Wenbin Yu, Junwei Huang, Hongbo Xu, Guojun Li, Xiaohong Chen,  and Zhigang Huang
14770-14776
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E2F-1 targets miR-519d to regulate the expression of the ras homolog gene family member C

E2F-1 targets miR-519d to regulate the expression of the ras homolog gene family member C

https://doi.org/10.18632/oncotarget.14833

Xiu-Bo Sang, Zhi-Hong Zong, Li-Li Wang, Dan-Dan Wu, Shuo Chen, Bo-Liang Liu,  and Yang Zhao
14777-14793
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Detection of CCNE1/URI (19q12) amplification by in situ hybridisation is common in high grade and type II endometrial cancer

Detection of CCNE1/URI (19q12) amplification by in situ hybridisation is common in high grade and type II endometrial cancer

https://doi.org/10.18632/oncotarget.11605

Aurelia Noske, Simone Brandt, Nadejda Valtcheva, Ulrich Wagner, Qing Zhong, Elisa Bellini, Daniel Fink, Ellen C. Obermann, Holger Moch,  and Peter J. Wild
14794-14805
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

hPaf1/PD2 interacts with OCT3/4 to promote self-renewal of ovarian cancer stem cells

hPaf1/PD2 interacts with OCT3/4 to promote self-renewal of ovarian cancer stem cells

https://doi.org/10.18632/oncotarget.14775

Saswati Karmakar, Parthasarathy Seshacharyulu, Imayavaramban Lakshmanan, Arokia P. Vaz, Seema Chugh, Yuri M. Sheinin, Sidharth Mahapatra, Surinder K. Batra,  and Moorthy P. Ponnusamy
14806-14820
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A methodological study of genome-wide DNA methylation analyses using matched archival formalin-fixed paraffin embedded and fresh frozen breast tumors

A methodological study of genome-wide DNA methylation analyses using matched archival formalin-fixed paraffin embedded and fresh frozen breast tumors

https://doi.org/10.18632/oncotarget.14739

Allyson C. Espinal, Dan Wang, Li Yan, Song Liu, Li Tang, Qiang Hu, Carl D. Morrison, Christine B. Ambrosone, Michael J. Higgins,  and Lara E. Sucheston- Campbell
14821-14829
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The conformational changes of Zika virus methyltransferase upon converting SAM to SAH

The conformational changes of Zika virus methyltransferase upon converting SAM to SAH

https://doi.org/10.18632/oncotarget.14780

Han Zhou, Fenghua Wang, Haofeng Wang, Cheng Chen, Tianqing Zhang, Xu Han, Deping Wang, Chen Chen, Chen Wu, Wei Xie, Zefang Wang, Lei Zhang, Lanfeng Wang,  and Haitao Yang
14830-14834
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MEK inhibition is a promising therapeutic strategy for MLL-rearranged infant acute lymphoblastic leukemia patients carrying RAS mutations

MEK inhibition is a promising therapeutic strategy for MLL-rearranged infant acute lymphoblastic leukemia patients carrying RAS mutations

https://doi.org/10.18632/oncotarget.11730

Mark Kerstjens, Emma M.C. Driessen, Merel Willekes, Sandra S. Pinhanços, Pauline Schneider, Rob Pieters,  and Ronald W. Stam
14835-14846
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Nuclear PRMT5, cyclin D1 and IL-6 are associated with poor outcome in oropharyngeal squamous cell carcinoma patients and is inversely associated with p16-status

Nuclear PRMT5, cyclin D1 and IL-6 are associated with poor outcome in oropharyngeal squamous cell carcinoma patients and is inversely associated with p16-status

https://doi.org/10.18632/oncotarget.14682

Bhavna Kumar, Arti Yadav, Nicole V. Brown, Songzhu Zhao, Michael J. Cipolla, Paul E. Wakely, Alessandra C. Schmitt, Robert A. Baiocchi, Theodoros N. Teknos, Matthew Old,  and Pawan Kumar
14847-14859
Abstract  |  PDF  |  HTML  |  Order a Reprint

Disabled cell density sensing leads to dysregulated cholesterol synthesis in glioblastoma

Disabled cell density sensing leads to dysregulated cholesterol synthesis in glioblastoma

https://doi.org/10.18632/oncotarget.14740

Diane M. Kambach, Alan S. Halim, A. Gesine Cauer, Qian Sun, Carlos A. Tristan, Orieta Celiku, Aparna H. Kesarwala, Uma Shankavaram, Eric Batchelor,  and Jayne M. Stommel
14860-14875
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A novel seven-long non-coding RNA signature predicts survival in early stage lung adenocarcinoma

A novel seven-long non-coding RNA signature predicts survival in early stage lung adenocarcinoma

https://doi.org/10.18632/oncotarget.14781

Mingwei Chen, Baoquan Liu, Jianbing Xiao, Yingnan Yang,  and Yafang Zhang
14876-14886
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MiR-155-5p positively regulates CCL17-induced colon cancer cell migration by targeting RhoA

MiR-155-5p positively regulates CCL17-induced colon cancer cell migration by targeting RhoA

https://doi.org/10.18632/oncotarget.14841

Amr A. Al-Haidari, Ingvar Syk,  and Henrik Thorlacius
14887-14896
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Cyclin E overexpression as a biomarker for combination treatment strategies in inflammatory breast cancer

Cyclin E overexpression as a biomarker for combination treatment strategies in inflammatory breast cancer

https://doi.org/10.18632/oncotarget.14689

Angela Alexander, Cansu Karakas, Xian Chen, Jason P.W. Carey, Min Yi, Melissa Bondy, Patricia Thompson, Kwok Leung Cheung, Ian O. Ellis, Yun Gong, Savitri Krishnamurthy, Ricardo H. Alvarez, Naoto T. Ueno, Kelly K. Hunt,  and Khandan Keyomarsi
14897-14911
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Tenovin-6 inhibits proliferation and survival of diffuse large B-cell lymphoma cells by blocking autophagy

Tenovin-6 inhibits proliferation and survival of diffuse large B-cell lymphoma cells by blocking autophagy

https://doi.org/10.18632/oncotarget.14741

Hongfeng Yuan, Meilan He, Fan Cheng, Rosemary Bai, Suzane Ramos da Silva, Ricardo C.T. Aguiar,  and Shou-Jiang Gao
14912-14924
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Molecularly targeted co-delivery of a histone deacetylase inhibitor and paclitaxel by lipid-protein hybrid nanoparticles for synergistic combinational chemotherapy

Molecularly targeted co-delivery of a histone deacetylase inhibitor and paclitaxel by lipid-protein hybrid nanoparticles for synergistic combinational chemotherapy

https://doi.org/10.18632/oncotarget.14742

Hima Bindu Ruttala, Thiruganesh Ramasamy, Bijay Kumar Poudal, Yongjoo Choi, Ju Yeon Choi, Jeonghwan Kim, Sae Kwang Ku, Han-Gon Choi, Chul Soon Yong,  and Jong Oh Kim
14925-14940
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The homeoprotein Dlx5 drives murine T-cell lymphomagenesis by directly transactivating Notch and upregulating Akt signaling

The homeoprotein Dlx5 drives murine T-cell lymphomagenesis by directly transactivating Notch and upregulating Akt signaling

https://doi.org/10.18632/oncotarget.14784

Yinfei Tan, Eleonora Sementino, Jinfei Xu, Jianming Pei, Zemin Liu, Timothy K. Ito, Kathy Q. Cai, Suraj Peri, Andres J.P. Klein-Szanto, David L. Wiest,  and Joseph R. Testa
14941-14956
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Intratumoral heterogeneity of intrahepatic cholangiocarcinoma

Intratumoral heterogeneity of intrahepatic cholangiocarcinoma

https://doi.org/10.18632/oncotarget.14844

Dirk Walter, Claudia Döring, Magdalena Feldhahn, Florian Battke, Sylvia Hartmann, Ria Winkelmann, Markus Schneider, Katrin Bankov, Andreas Schnitzbauer, Stefan Zeuzem, Martin Leo Hansmann,  and Jan Peveling-Oberhag
14957-14968
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The impact of intratumoral metabolic heterogeneity on postoperative recurrence and survival in resectable esophageal squamous cell carcinoma

The impact of intratumoral metabolic heterogeneity on postoperative recurrence and survival in resectable esophageal squamous cell carcinoma

https://doi.org/10.18632/oncotarget.14743

Xinzhe Dong, Xiaorong Sun, Xianguang Zhao, Wanqi Zhu, Lu Sun, Yong Huang, Wenwu Li, Honglin Wan, Ligang Xing,  and Jinming Yu
14969-14977
Abstract  |  PDF  |  HTML  |  Order a Reprint

Activation of Akt by SC79 protects myocardiocytes from oxygen and glucose deprivation (OGD)/re-oxygenation

Activation of Akt by SC79 protects myocardiocytes from oxygen and glucose deprivation (OGD)/re-oxygenation

https://doi.org/10.18632/oncotarget.14785

Koulong Zheng, Qing Zhang, Gang Lin, Yefei Li, Zhenqiang Sheng, Jue Wang, Liang Chen,  and Hui-he Lu
14978-14987
Abstract  |  PDF  |  HTML  |  Order a Reprint

High level of viral microRNA-BART20-5p expression is associated with worse survival of patients with Epstein-Barr virus-associated gastric cancer

High level of viral microRNA-BART20-5p expression is associated with worse survival of patients with Epstein-Barr virus-associated gastric cancer

https://doi.org/10.18632/oncotarget.14744

Byung Woog Kang, YongHun Choi, Oh Kyoung Kwon, Seung Soo Lee, Ho Young Chung, Wansik Yu, Han Ik Bae, An Na Seo, Hyojeung Kang, Suk Kyeong Lee, Seong Woo Jeon, Keun Hur,  and Jong Gwang Kim
14988-14994
Abstract  |  PDF  |  HTML  |  Order a Reprint

Prognostic role of N-Acetylgalactosaminyltransferase 10 in metastatic renal cell carcinoma

Prognostic role of N-Acetylgalactosaminyltransferase 10 in metastatic renal cell carcinoma

https://doi.org/10.18632/oncotarget.14786

Li Liu, Ying Xiong, Wei Xi, Jiajun Wang, Yang Qu, Zhiyuan Lin, Xiang Chen, Jiaxi Yao, Jiejie Xu,  and Jianming Guo
14995-15003
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Prognostic significance of positive peritoneal cytology in resectable pancreatic cancer: a systemic review and meta-analysis

Prognostic significance of positive peritoneal cytology in resectable pancreatic cancer: a systemic review and meta-analysis

https://doi.org/10.18632/oncotarget.14745

Feng Cao, Jia Li, Ang Li,  and Fei Li
15004-15013
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Acquired resistance to LY2874455 in FGFR2-amplified gastric cancer through an emergence of novel FGFR2-ACSL5 fusion

Acquired resistance to LY2874455 in FGFR2-amplified gastric cancer through an emergence of novel FGFR2-ACSL5 fusion

https://doi.org/10.18632/oncotarget.14788

Sun Young Kim, Taejin Ahn, Heejin Bang, Jun Soo Ham, Jusun Kim, Seung Tae Kim, Jiryeon Jang, Moonhee Shim, So Young Kang, Se Hoon Park, Byung Hoon Min, Hyuk Lee, Won Ki Kang, Kyoung-Mee Kim, Woongyang Park,  and Jeeyun Lee
15014-15022
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Epidermal growth factor receptor (EGFR) mutations in non-small cell lung cancer (NSCLC) of Yunnan in southwestern China

Epidermal growth factor receptor (EGFR) mutations in non-small cell lung cancer (NSCLC) of Yunnan in southwestern China

https://doi.org/10.18632/oncotarget.14706

Yongchun Zhou, Yanlong Yang, Chenggang Yang, Yunlan Chen, Changshao Yang, Yaxi Du, Guangqiang Zhao, Yinjin Guo, Lianhua Ye,  and Yunchao Huang
15023-15033
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Targeted breast cancer therapy by harnessing the inherent blood group antigen immune system

Targeted breast cancer therapy by harnessing the inherent blood group antigen immune system

https://doi.org/10.18632/oncotarget.14746

Wei Han, Wei Li, Xiaoying Zhang, Zhonghua Du, Xiaoliang Liu, Xin Zhao, Xue Wen, Guanjun Wang, Ji-Fan Hu,  and Jiuwei Cui
15034-15046
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Effects of antiviral therapy on post-hepatectomy HBV reactivation and liver function in HBV DNA-negative patients with HBV-related hepatocellular carcinoma

Effects of antiviral therapy on post-hepatectomy HBV reactivation and liver function in HBV DNA-negative patients with HBV-related hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.14789

Wen-Feng Gong, Jian-Hong Zhong, Shi-Dong Lu, Xiao-Bo Wang, Qiu-Ming Zhang, Liang Ma, Zhi-Ming Zhang, Bang-De Xiang,  and Le-Qun Li
15047-15056
Abstract  |  PDF  |  HTML  |  Order a Reprint

Peroxiredoxin 2 is associated with colorectal cancer progression and poor survival of patients

Peroxiredoxin 2 is associated with colorectal cancer progression and poor survival of patients

https://doi.org/10.18632/oncotarget.14801

LingLong Peng, Rong Wang, JingKun Shang, YongFu Xiong,  and ZhongXue Fu
15057-15070
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Epigenetic silencing of XAF1 in high-grade gliomas is associated with IDH1 status and improved clinical outcome

Epigenetic silencing of XAF1 in high-grade gliomas is associated with IDH1 status and improved clinical outcome

https://doi.org/10.18632/oncotarget.14748

Thomas R. Reich, Olivier J. Switzeny, Mirjam Renovanz, Clemens Sommer, Bernd Kaina, Markus Christmann,  and Maja T. Tomicic
15071-15084
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Boosting the hypoxic response in myeloid cells accelerates resolution of fibrosis and regeneration of the liver in mice

Boosting the hypoxic response in myeloid cells accelerates resolution of fibrosis and regeneration of the liver in mice

https://doi.org/10.18632/oncotarget.14749

Chahrazade Kantari-Mimoun, Ewelina Krzywinska, Magali Castells, Corinne Milien, Ralph Klose, Anna-Katharina Meinecke, Ursula Lemberger, Thomas Mathivet, Milos Gojkovic, Katrin Schrödter, Christoph Österreicher, Joachim Fandrey, Helene Rundqvist,  and Christian Stockmann
15085-15100
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Comparing the long-term efficacy of standard and combined minimally invasive procedures for unresectable HCC: a mixed treatment comparison

Comparing the long-term efficacy of standard and combined minimally invasive procedures for unresectable HCC: a mixed treatment comparison

https://doi.org/10.18632/oncotarget.13145

Jianghai Zhao, Hui Zhang, Lunshou Wei, Shuping Xie,  and Zhimin Suo
15101-15113
Abstract  |  PDF  |  HTML  |  Order a Reprint

SETD6 regulates NF-κB signaling in urothelial cell survival: Implications for bladder cancer

SETD6 regulates NF-κB signaling in urothelial cell survival: Implications for bladder cancer

https://doi.org/10.18632/oncotarget.14750

Neelam Mukherjee, Eduardo Cardenas, Roble Bedolla,  and Rita Ghosh
15114-15125
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Association of plasma ghrelin levels and ghrelin rs4684677 polymorphism with mild cognitive impairment in type 2 diabetic patients

Association of plasma ghrelin levels and ghrelin rs4684677 polymorphism with mild cognitive impairment in type 2 diabetic patients

https://doi.org/10.18632/oncotarget.14852

Rong Huang, Jing Han, Sai Tian, Rongrong Cai, Jie Sun, Yanjue Shen,  and Shaohua Wang
15126-15135
Abstract  |  PDF  |  HTML  |  Order a Reprint

Genome-wide DNA copy number analysis in clonally expanded human ovarian cancer cells with distinct invasive/migratory capacities

Genome-wide DNA copy number analysis in clonally expanded human ovarian cancer cells with distinct invasive/migratory capacities

https://doi.org/10.18632/oncotarget.14767

Lei Li, Huimin Bai, Jiaxin Yang, Dongyan Cao,  and Keng Shen
15136-15148
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Germacrone derivatives: synthesis, biological activity, molecular docking studies and molecular dynamics simulations

Germacrone derivatives: synthesis, biological activity, molecular docking studies and molecular dynamics simulations

https://doi.org/10.18632/oncotarget.14832

Jie Wu, Yu Feng, Chao Han, Wu Huang, Zhibin Shen, Mengdie Yang, Weiqiang Chen,  and Lianbao Ye
15149-15158
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The prognostic relevance of primary tumor location in patients undergoing resection for pancreatic ductal adenocarcinoma

The prognostic relevance of primary tumor location in patients undergoing resection for pancreatic ductal adenocarcinoma

https://doi.org/10.18632/oncotarget.14768

Qi Ling, Xiao Xu, Panpan Ye, Haiyang Xie, Feng Gao, Qichao Hu, Zhikun Liu, Xuyong Wei, Christian Röder, Anna Trauzold, Holger Kalthoff,  and Shusen Zheng
15159-15167
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Colorectal cancer cells suppress CD4+ T cells immunity through canonical Wnt signaling

Colorectal cancer cells suppress CD4+ T cells immunity through canonical Wnt signaling

https://doi.org/10.18632/oncotarget.14834

Xuan Sun, Suoning Liu, Daguang Wang, Yang Zhang, Wei Li, Yuchen Guo, Hua Zhang,  and Jian Suo
15168-15181
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

High-dose radiotherapy is associated with better local control of bone metastasis from hepatocellular carcinoma

High-dose radiotherapy is associated with better local control of bone metastasis from hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.14858

In-Hye Jung, Sang Min Yoon, Jungwon Kwak, Jin-Hong Park, Si Yeol Song, Sang-wook Lee, Seung Do Ahn, Eun Kyung Choi,  and Jong Hoon Kim
15182-15192
Abstract  |  PDF  |  HTML  |  Order a Reprint

Factors associated with ethnical disparity in overall survival for patients with hepatocellular carcinoma

Factors associated with ethnical disparity in overall survival for patients with hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.14771

Juan Li, Bettina E. Hansen, Maikel P. Peppelenbosch, Robert A. De Man, Qiuwei Pan,  and Dave Sprengers
15193-15204
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Regulation of hepatic pyruvate dehydrogenase phosphorylation in offspring glucose intolerance induced by intrauterine hyperglycemia

Regulation of hepatic pyruvate dehydrogenase phosphorylation in offspring glucose intolerance induced by intrauterine hyperglycemia

https://doi.org/10.18632/oncotarget.14837

Yong Zhang, Ying Zhang, Guo-Lian Ding, Xin-Mei Liu, Jianping Ye, Jian-Zhong Sheng, Jianxia Fan,  and He-Feng Huang
15205-15212
Abstract  |  PDF  |  HTML  |  Order a Reprint

CX3CL1: a potential chemokine widely involved in the process spinal metastases

CX3CL1: a potential chemokine widely involved in the process spinal metastases

https://doi.org/10.18632/oncotarget.14773

WangMi Liu, Chong Bian, Yun Liang, Libo Jiang, Chen Qian,  and Jian Dong
15213-15219
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Up-regulation of tumor suppressor genes by exogenous dhC16-Cer contributes to its anti-cancer activity in primary effusion lymphoma

Up-regulation of tumor suppressor genes by exogenous dhC16-Cer contributes to its anti-cancer activity in primary effusion lymphoma

https://doi.org/10.18632/oncotarget.14838

Yueyu Cao, Jing Qiao, Zhen Lin, Jovanny Zabaleta, Lu Dai,  and Zhiqiang Qin
15220-15229
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Plumbagin restrains hepatocellular carcinoma angiogenesis by suppressing the migration and invasion of tumor-derived vascular endothelial cells

Plumbagin restrains hepatocellular carcinoma angiogenesis by suppressing the migration and invasion of tumor-derived vascular endothelial cells

https://doi.org/10.18632/oncotarget.14774

YanFei Wei, Qi Yang, Yuan Zhang, TieJian Zhao, XueMei Liu, Jing Zhong, Jing Ma, YongXin Chen, Chuan Zhao,  and JunXuan Li
15230-15241
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Posttranscriptional regulation of Galectin-3 by miR-128 contributes to colorectal cancer progression

Posttranscriptional regulation of Galectin-3 by miR-128 contributes to colorectal cancer progression

https://doi.org/10.18632/oncotarget.14839

Weiqun Lu, Jia Wang, Guohua Yang, Nanrong Yu, Zhiliang Huang, Houwei Xu, Jianchang Li, Jiliang Qiu, Xiang Zeng, Shicai Chen, Nan Li,  and Haiying Liu
15242-15251
Abstract  |  PDF  |  HTML  |  Order a Reprint

Selective extracellular vesicle exclusion of miR-142-3p by oral cancer cells promotes both internal and extracellular malignant phenotypes

Selective extracellular vesicle exclusion of miR-142-3p by oral cancer cells promotes both internal and extracellular malignant phenotypes

https://doi.org/10.18632/oncotarget.14862

Christopher T.D. Dickman, James Lawson, James Jabalee, Sara A. MacLellan, Nancy E. LePard, Kevin L. Bennewith,  and Cathie Garnis
15252-15266
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Ex vivo 2D and 3D HSV-2 infection model using human normal vaginal epithelial cells

Ex vivo 2D and 3D HSV-2 infection model using human normal vaginal epithelial cells

https://doi.org/10.18632/oncotarget.14840

Yaqi Zhu, Yan Yang, Juanjuan Guo, Ying Dai, Lina Ye, Jianbin Qiu, Zhihong Zeng, Xiaoting Wu, Yanmei Xing, Xiang Long, Xufeng Wu, Lin Ye, Shubin Wang,  and Hui Li
15267-15282
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Relationship between LINC00341 expression and cancer prognosis

Relationship between LINC00341 expression and cancer prognosis

https://doi.org/10.18632/oncotarget.14843

Meijian Liao, Bing Li, Shikuan Zhang, Qing Liu, Weijie Liao, Weidong Xie,  and Yaou Zhang
15283-15293
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Integrative miRNA and mRNA analysis in penile carcinomas reveals markers and pathways with potential clinical impact

Integrative miRNA and mRNA analysis in penile carcinomas reveals markers and pathways with potential clinical impact

https://doi.org/10.18632/oncotarget.14783

Hellen Kuasne, Mateus C. Barros-Filho, Ariane Busso-Lopes, Fábio A. Marchi, Maisa Pinheiro, Juan J. M. Muñoz, Cristovam Scapulatempo-Neto, Eliney F. Faria, Gustavo C. Guimarães, Ademar Lopes, José C. S. Trindade-Filho, Maria Aparecida C. Domingues, Sandra A. Drigo,  and Silvia R. Rogatto
15294-15306
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Probing the prostate tumour microenvironment II: Impact of hypoxia on a cell model of prostate cancer progression

Probing the prostate tumour microenvironment II: Impact of hypoxia on a cell model of prostate cancer progression

https://doi.org/10.18632/oncotarget.14574

Claire Tonry, John Armstrong,  and Stephen Pennington
15307-15337
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Tumor-associated NADH oxidase (tNOX)-NAD+-sirtuin 1 axis contributes to oxaliplatin-induced apoptosis of gastric cancer cells

Tumor-associated NADH oxidase (tNOX)-NAD+-sirtuin 1 axis contributes to oxaliplatin-induced apoptosis of gastric cancer cells

https://doi.org/10.18632/oncotarget.14787

Huei-Yu Chen, Hsiao-Ling Cheng, Yi-Hui Lee, Tien-Ming Yuan, Shi-Wen Chen, You-Yu Lin,  and Pin Ju Chueh
15338-15348
Abstract  |  PDF  |  HTML  |  Order a Reprint

Integrative computational analysis of transcriptional and epigenetic alterations implicates DTX1 as a putative tumor suppressor gene in HNSCC

Integrative computational analysis of transcriptional and epigenetic alterations implicates DTX1 as a putative tumor suppressor gene in HNSCC

https://doi.org/10.18632/oncotarget.14856

Daria A. Gaykalova, Veronika Zizkova, Theresa Guo, Ilse Tiscareno, Yingying Wei, Rajita Vatapalli, Patrick T. Hennessey, Julie Ahn, Ludmila Danilova, Zubair Khan, Justin A. Bishop, J. Silvio Gutkind, Wayne M. Koch, William H. Westra, Elana J. Fertig, Michael F. Ochs,  and Joseph A. Califano
15349-15363
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

FM807, a curcumin analogue, shows potent antitumor effects in nasopharyngeal carcinoma cells by heat shock protein 90 inhibition

FM807, a curcumin analogue, shows potent antitumor effects in nasopharyngeal carcinoma cells by heat shock protein 90 inhibition

https://doi.org/10.18632/oncotarget.14970

Min Ye, Wei Huang, Wen-wei Wu, Yang Liu, Sheng-nan Ye,  and Jian-hua Xu
15364-15376
Abstract  |  PDF  |  HTML  |  Order a Reprint

Hyperhomocysteinemia results from and promotes hepatocellular carcinoma via CYP450 metabolism by CYP2J2 DNA methylation

Hyperhomocysteinemia results from and promotes hepatocellular carcinoma via CYP450 metabolism by CYP2J2 DNA methylation

https://doi.org/10.18632/oncotarget.14165

Donghong Zhang, Jinli Lou, Xu Zhang, Lin Zhang, Fei Wang, Danfei Xu, Na Niu, Yidong Wang, Yue Wu,  and Wei Cui
15377-15392
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Silence of cancer susceptibility candidate 9 inhibits gastric cancer and reverses chemoresistance

Silence of cancer susceptibility candidate 9 inhibits gastric cancer and reverses chemoresistance

https://doi.org/10.18632/oncotarget.14871

Chao Shang, Lin Sun, Jiale Zhang, Bochao Zhao, Xiuxiu Chen, Huimian Xu,  and Baojun Huang
15393-15398
Abstract  |  PDF  |  HTML  |  Order a Reprint

Elevated NF-κB signaling in Asherman syndrome patients and animal models

Elevated NF-κB signaling in Asherman syndrome patients and animal models

https://doi.org/10.18632/oncotarget.14853

Xiangzhen Wang, Nana Ma, Qiannan Sun, Chenlingzi Huang, Yanmei Liu,  and Xin Luo
15399-15406
Abstract  |  PDF  |  HTML  |  Order a Reprint

uPAR-targeted optical near-infrared (NIR) fluorescence imaging and PET for image-guided surgery in head and neck cancer: proof-of-concept in orthotopic xenograft model

uPAR-targeted optical near-infrared (NIR) fluorescence imaging and PET for image-guided surgery in head and neck cancer: proof-of-concept in orthotopic xenograft model

https://doi.org/10.18632/oncotarget.14282

Anders Christensen, Karina Juhl, Morten Persson, Birgitte Wittenborg Charabi, Jann Mortensen, Katalin Kiss, Giedrius Lelkaitis, Niclas Rubek, Christian von Buchwald,  and Andreas Kjær
15407-15419
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Increased autophagy in fibroblast-like synoviocytes leads to immune enhancement potential in rheumatoid arthritis

Increased autophagy in fibroblast-like synoviocytes leads to immune enhancement potential in rheumatoid arthritis

https://doi.org/10.18632/oncotarget.14331

Ru Yang, Yingzi Zhang, Lin Wang, Ji Hu, Jian Wen, Leixi Xue, Mei Tang, Zhichun Liu,  and Jinxiang Fu
15420-15430
Abstract  |  PDF  |  HTML  |  Order a Reprint

Promoter methylation of MCAM, ERα and ERβ in serum of early stage prostate cancer patients

Promoter methylation of MCAM, ERα and ERβ in serum of early stage prostate cancer patients

https://doi.org/10.18632/oncotarget.14873

Mariana Brait, Mithu Banerjee, Leonel Maldonado, Akira Ooki, Myriam Loyo, Elisa Guida, Evgeny Izumchenko, Leslie Mangold, Elizabeth Humphreys, Eli Rosenbaum, Alan Partin, David Sidransky,  and Mohammad Obaidul Hoque
15431-15440
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

L1 increases adhesion-mediated proliferation and chemoresistance of retinoblastoma

L1 increases adhesion-mediated proliferation and chemoresistance of retinoblastoma

https://doi.org/10.18632/oncotarget.14487

Dong Hyun Jo, Kyungmin Lee, Jin Hyoung Kim, Hyoung Oh Jun, Younghoon Kim, Young-Lai Cho, Young Suk Yu, Jeong-Ki Min,  and Jeong Hun Kim
15441-15452
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

LncSubpathway: a novel approach for identifying dysfunctional subpathways associated with risk lncRNAs by integrating lncRNA and mRNA expression profiles and pathway topologies

LncSubpathway: a novel approach for identifying dysfunctional subpathways associated with risk lncRNAs by integrating lncRNA and mRNA expression profiles and pathway topologies

https://doi.org/10.18632/oncotarget.14973

Yanjun Xu, Feng Li, Tan Wu, Yingqi Xu, Haixiu Yang, Qun Dong, Meiyu Zheng, Desi Shang, Chunlong Zhang, Yunpeng Zhang,  and Xia Li
15453-15469
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Characteristics of Chinese herbal medicine usage in ischemic heart disease patients among type 2 diabetes and their protection against hydrogen peroxide-mediated apoptosis in H9C2 cardiomyoblasts

Characteristics of Chinese herbal medicine usage in ischemic heart disease patients among type 2 diabetes and their protection against hydrogen peroxide-mediated apoptosis in H9C2 cardiomyoblasts

https://doi.org/10.18632/oncotarget.14657

Fuu-Jen Tsai, Tsung-Jung Ho, Chi-Fung Cheng, Yi-Tzone Shiao, Wen-Kuei Chien, Jin-Hua Chen, Xiang Liu, Hsinyi Tsang, Ting-Hsu Lin, Chiu-Chu Liao, Shao-Mei Huang, Ju-Pi Li, Cheng-Wen Lin, Jaung-Geng Lin, Yu-Ching Lan, Yu-Huei Liu, Chien-Hui Hung, Jung-Chun Lin, Chih-Chien Lin, Chih-Ho Lai, Wen-Miin Liang,  and Ying-Ju Lin
15470-15489
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Bigh3 silencing increases retinoblastoma tumor growth in the murine SV40-TAg-Rb model

Bigh3 silencing increases retinoblastoma tumor growth in the murine SV40-TAg-Rb model

https://doi.org/10.18632/oncotarget.14659

Nathalie Allaman-Pillet, Anne Oberson,  and Daniel F. Schorderet
15490-15506
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

In vivo and in vitro effects of microRNA-27a on proliferation, migration and invasion of breast cancer cells through targeting of SFRP1 gene via Wnt/β-catenin signaling pathway

In vivo and in vitro effects of microRNA-27a on proliferation, migration and invasion of breast cancer cells through targeting of SFRP1 gene via Wnt/β-catenin signaling pathway

https://doi.org/10.18632/oncotarget.14662

Ling-Yu Kong, Mei Xue, Qing-Cai Zhang,  and Chuan-Fu Su
15507-15519
Abstract  |  PDF  |  HTML  |  Order a Reprint

The nitrobenzoxadiazole derivative MC3181 blocks melanoma invasion and metastasis

The nitrobenzoxadiazole derivative MC3181 blocks melanoma invasion and metastasis

https://doi.org/10.18632/oncotarget.14690

Anastasia De Luca, Debora Carpanese, Maria Cristina Rapanotti, Tara Mayte Suarez Viguria, Maria Antonietta Forgione, Dante Rotili, Chiara Fulci, Egidio Iorio, Luigi Quintieri, Sergio Chimenti, Luca Bianchi, Antonio Rosato,  and Anna Maria Caccuri
15520-15538
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Tunneling nanotubes promote intercellular mitochondria transfer followed by increased invasiveness in bladder cancer cells

Tunneling nanotubes promote intercellular mitochondria transfer followed by increased invasiveness in bladder cancer cells

https://doi.org/10.18632/oncotarget.14695

Jinjin Lu, Xiufen Zheng, Fan Li, Yang Yu, Zhong Chen, Zheng Liu, Zhihua Wang, Hua Xu,  and Weimin Yang
15539-15552
Abstract  |  PDF  |  HTML  |  Order a Reprint

Kalirin and CHD7: novel endothelial dysfunction indicators in circulating extracellular vesicles from hypertensive patients with albuminuria

Kalirin and CHD7: novel endothelial dysfunction indicators in circulating extracellular vesicles from hypertensive patients with albuminuria

https://doi.org/10.18632/oncotarget.14948

Fernando de la Cuesta, Montserrat Baldan-Martin, Rafael Moreno-Luna, Gloria Alvarez-Llamas, Laura Gonzalez-Calero, Laura Mourino-Alvarez, Tamara Sastre-Oliva, Juan A. López, Jesús Vázquez, Gema Ruiz-Hurtado, Julian Segura, Fernando Vivanco, Luis M. Ruilope,  and Maria G. Barderas
15553-15562
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Hyaluronan synthase 3 mediated oncogenic action through forming inter-regulation loop with tumor necrosis factor alpha in oral cancer

Hyaluronan synthase 3 mediated oncogenic action through forming inter-regulation loop with tumor necrosis factor alpha in oral cancer

https://doi.org/10.18632/oncotarget.14697

Yi-Zih Kuo, Wei-Yu Fang, Cheng-Chih Huang, Sen-Tien Tsai, Yi-Ching Wang, Chih-Li Yang,  and Li-Wha Wu
15563-15583
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The combination of PD-L1 expression and decreased tumor-infiltrating lymphocytes is associated with a poor prognosis in triple-negative breast cancer

The combination of PD-L1 expression and decreased tumor-infiltrating lymphocytes is associated with a poor prognosis in triple-negative breast cancer

https://doi.org/10.18632/oncotarget.14698

Hitomi Mori, Makoto Kubo, Rin Yamaguchi, Reiki Nishimura, Tomofumi Osako, Nobuyuki Arima, Yasuhiro Okumura, Masayuki Okido, Mai Yamada, Masaya Kai, Junji Kishimoto, Yoshinao Oda,  and Masafumi Nakamura
15584-15592
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Differential expression of CD44 and CD24 markers discriminates the epitheliod from the fibroblastoid subset in a sarcomatoid renal carcinoma cell line: evidence suggesting the existence of cancer stem cells in both subsets as studied with sorted cells

Differential expression of CD44 and CD24 markers discriminates the epitheliod from the fibroblastoid subset in a sarcomatoid renal carcinoma cell line: evidence suggesting the existence of cancer stem cells in both subsets as studied with sorted cells

https://doi.org/10.18632/oncotarget.14777

Chin-Hsuan Hsieh, Shih-Chieh Hsiung, Chi-Tai Yeh, Chih-Feng Yen, Yah-Huei Wu Chou, Wei-Yi Lei, See-Tong Pang, Cheng-Keng Chuang,  and Shuen-Kuei Liao
15593-15609
Abstract  |  PDF  |  HTML  |  Order a Reprint

Combined evaluation of the FAS cell surface death receptor and CD8+ tumor infiltrating lymphocytes as a prognostic biomarker in breast cancer

Combined evaluation of the FAS cell surface death receptor and CD8+ tumor infiltrating lymphocytes as a prognostic biomarker in breast cancer

https://doi.org/10.18632/oncotarget.14779

Erik J. Blok, Jitske van den Bulk, N. Geeske Dekker-Ensink, Remco Derr, Corné Kanters, Esther Bastiaannet, Judith R. Kroep, Cornelis J.H. van de Velde,  and Peter J.K. Kuppen
15610-15620
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The prognostic value of tumor-infiltrating T lymphocytes in ovarian cancer

The prognostic value of tumor-infiltrating T lymphocytes in ovarian cancer

https://doi.org/10.18632/oncotarget.14919

Jun Li, Jieyu Wang, Ruifang Chen, Yang Bai,  and Xin Lu
15621-15631
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Prognostic value of combination of preoperative platelet count and mean platelet volume in patients with resectable non-small cell lung cancer

Prognostic value of combination of preoperative platelet count and mean platelet volume in patients with resectable non-small cell lung cancer

https://doi.org/10.18632/oncotarget.14921

Liuwei Gao, Hua Zhang, Bin Zhang, Lianmin Zhang,  and Changli Wang
15632-15641
Abstract  |  PDF  |  HTML  |  Order a Reprint

Mean cerebral blood volume is an effective diagnostic index of recurrent and radiation injury in glioma patients: A meta-analysis of diagnostic test

Mean cerebral blood volume is an effective diagnostic index of recurrent and radiation injury in glioma patients: A meta-analysis of diagnostic test

https://doi.org/10.18632/oncotarget.14922

Zhanzhan Li, Qin Zhou, Yanyan Li, Shipeng Yan, Jun Fu, Xinqiong Huang,  and Liangfang Shen
15642-15650
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Detection fidelity of AR mutations in plasma derived cell-free DNA

Detection fidelity of AR mutations in plasma derived cell-free DNA

https://doi.org/10.18632/oncotarget.14926

Alexa Goldstein, Patricia Valda Toro, Justin Lee, John L. Silberstein, Mary Nakazawa, Ian Waters, Karen Cravero, David Chu, Rory L. Cochran, Minsoo Kim, Daniel Shinn, Samantha Torquato, Robert M. Hughes, Aparna Pallavajjala, Michael A. Carducci, Channing J. Paller, Samuel R. Denmeade, Bruce Kressel, Bruce Trock, Mario A. Eisenberger, Emmanuel S. Antonarakis, Ben H. Park,  and Paula J. Hurley
15651-15662
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Klotho suppresses the inflammatory responses and ameliorates cardiac dysfunction in aging endotoxemic mice

Klotho suppresses the inflammatory responses and ameliorates cardiac dysfunction in aging endotoxemic mice

https://doi.org/10.18632/oncotarget.14933

Haipeng Hui, Yufeng Zhai, Lihua Ao, Joseph C. Cleveland Jr, Hongbin Liu, David A. Fullerton,  and Xianzhong Meng
15663-15676
Abstract  |  PDF  |  HTML  |  Order a Reprint

Propiece IL-1α facilitates the growth of acute T-lymphocytic leukemia cells through the activation of NF-κB and SP1

Propiece IL-1α facilitates the growth of acute T-lymphocytic leukemia cells through the activation of NF-κB and SP1

https://doi.org/10.18632/oncotarget.14934

Yinsheng Zhang, Xiao Yu, Dandan Lin, Lei Lei, Bo Hu, Fengzhang Cao, Yu Mei, Depei Wu,  and Haiyan Liu
15677-15688
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

TNFAIP8 interacts with LATS1 and promotes aggressiveness through regulation of Hippo pathway in hepatocellular carcinoma

TNFAIP8 interacts with LATS1 and promotes aggressiveness through regulation of Hippo pathway in hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.14938

Qianze Dong, Lin Fu, Yue Zhao, Chengyao Xie, Qingchang Li,  and Enhua Wang
15689-15703
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Novel HBsAg mutations correlate with hepatocellular carcinoma, hamper HBsAg secretion and promote cell proliferation in vitro

Novel HBsAg mutations correlate with hepatocellular carcinoma, hamper HBsAg secretion and promote cell proliferation in vitro

https://doi.org/10.18632/oncotarget.14944

Romina Salpini, Matteo Surdo, Nadia Warner, Maria Francesca Cortese, Danny Colledge, Sally Soppe, Maria Concetta Bellocchi, Daniele Armenia, Luca Carioti, Fabio Continenza, Domenico Di Carlo, Patrizia Saccomandi, Carmen Mirabelli, Michela Pollicita, Roberta Longo, Sara Romano, Giuseppina Cappiello, Alberto Spanò, Pascale Trimoulet, Herve Fleury, Jacopo Vecchiet, Nerio Iapadre, Angelo Barlattani, Ada Bertoli, Terenzio Mari, Caterina Pasquazzi, Gabriele Missale, Cesare Sarrecchia, Elisa Orecchini, Alessandro Michienzi, Massimo Andreoni, Simona Francioso, Mario Angelico, Jens Verheyen, Francesca Ceccherini-Silberstein, Stephen Locarnini, Carlo Federico Perno,  and Valentina Svicher
15704-15715
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A long term, non-tumorigenic rat hepatocyte cell line and its malignant counterpart, as tools to study hepatocarcinogenesis

A long term, non-tumorigenic rat hepatocyte cell line and its malignant counterpart, as tools to study hepatocarcinogenesis

https://doi.org/10.18632/oncotarget.14984

Maria Maddalena Angioni, Kevin Bellofatto, Simone Merlin, Silvia Menegon, Andrea Perra, Annalisa Petrelli, Pia Sulas, Silvia Giordano, Amedeo Columbano,  and Antonia Follenzi
15716-15731
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

SerpinB3 upregulates the Cyclooxygenase-2 / β-Catenin positive loop in colorectal cancer

SerpinB3 upregulates the Cyclooxygenase-2 / β-Catenin positive loop in colorectal cancer

https://doi.org/10.18632/oncotarget.14997

Liliana Terrin, Marco Agostini, Mariagrazia Ruvoletto, Andrea Martini, Salvatore Pucciarelli, Chiara Bettin, Donato Nitti,  and Patrizia Pontisso
15732-15743
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Stromal fibroblasts present in breast carcinomas promote tumor growth and angiogenesis through adrenomedullin secretion

Stromal fibroblasts present in breast carcinomas promote tumor growth and angiogenesis through adrenomedullin secretion

https://doi.org/10.18632/oncotarget.14999

Zohra Benyahia, Nadège Dussault, Mylène Cayol, Romain Sigaud, Caroline Berenguer-Daizé, Christine Delfino, Asma Tounsi, Stéphane Garcia, Pierre-Marie Martin, Kamel Mabrouk,  and L’Houcine Ouafik
15744-15762
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

STAT3 is required for MiR-17-5p-mediated sensitization to chemotherapy-induced apoptosis in breast cancer cells

STAT3 is required for MiR-17-5p-mediated sensitization to chemotherapy-induced apoptosis in breast cancer cells

https://doi.org/10.18632/oncotarget.15000

Xing-Hua Liao, Yuan Xiang, Cheng-Xi Yu, Jia-Peng Li, Hui Li, Qi Nie, Peng Hu, Jun Zhou,  and Tong-Cun Zhang
15763-15774
Abstract  |  PDF  |  HTML  |  Order a Reprint

Stathmin decreases cholangiocarcinoma cell line sensitivity to staurosporine-triggered apoptosis via the induction of ERK and Akt signaling

Stathmin decreases cholangiocarcinoma cell line sensitivity to staurosporine-triggered apoptosis via the induction of ERK and Akt signaling

https://doi.org/10.18632/oncotarget.15005

Yueqi Wang, Zhihui Gao, Dexiang Zhang, Xiaobo Bo, Yaojie Wang, Jiwen Wang, Sheng Shen, Han Liu, Tao Suo, Hongtao Pan, Zhilong Ai,  and Houbao Liu
15775-15788
Abstract  |  PDF  |  HTML  |  Order a Reprint

CHL1 hypermethylation as a potential biomarker of poor prognosis in breast cancer

CHL1 hypermethylation as a potential biomarker of poor prognosis in breast cancer

https://doi.org/10.18632/oncotarget.15004

Esperanza Martin-Sanchez, Saioa Mendaza, Ane Ulazia-Garmendia, Inaki Monreal-Santesteban, Idoia Blanco-Luquin, Alicia Cordoba, Francisco Vicente-Garcia, Noemi Perez-Janices, David Escors, Diego Megias, Paula Lopez-Serra, Manel Esteller, Jose Juan Illarramendi,  and David Guerrero-Setas
15789-15801
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Liver X receptors agonist GW3965 re-sensitizes gefitinib-resistant human non-small cell lung cancer cell to gefitinib treatment by inhibiting NF-κB in vitro

Liver X receptors agonist GW3965 re-sensitizes gefitinib-resistant human non-small cell lung cancer cell to gefitinib treatment by inhibiting NF-κB in vitro

https://doi.org/10.18632/oncotarget.15007

Yong Hu, Jialan Zang, Haixia Cao, Ying Wu, Dali Yan, Xiaobing Qin, Leilei Zhou, Fan Fan, Jie Ni, Xiaoyue Xu, Huanhuan Sha, Siwen Liu, Shaorong Yu, Zhuo Wang, Rong Ma, Jianzhong Wu,  and Jifeng Feng
15802-15814
Abstract  |  PDF  |  HTML  |  Order a Reprint

Significant prognostic value of circulating tumor cells in esophageal cancer patients: A meta-analysis

Significant prognostic value of circulating tumor cells in esophageal cancer patients: A meta-analysis

https://doi.org/10.18632/oncotarget.15012

Shuyu Wang, Hongyang Du,  and Guixia Li
15815-15826
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

PLK1 inhibition enhances temozolomide efficacy in IDH1 mutant gliomas

PLK1 inhibition enhances temozolomide efficacy in IDH1 mutant gliomas

https://doi.org/10.18632/oncotarget.15015

Robert F. Koncar, Zhengtao Chu, Lindsey E. Romick-Rosendale, Susanne I. Wells, Timothy A. Chan, Xiaoyang Qi,  and El Mustapha Bahassi
15827-15837
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Association between single nucleotide variants of vascular endothelial growth factor A and the risk of thyroid carcinoma and nodular goiter in a Han Chinese population

Association between single nucleotide variants of vascular endothelial growth factor A and the risk of thyroid carcinoma and nodular goiter in a Han Chinese population

https://doi.org/10.18632/oncotarget.15028

Rui Liu, Lifeng Ning, Xiaoli Liu, Huiping Zhang, Yaqin Yu, Shangchao Zhang, Wenwang Rao, Jieping Shi, Hui Sun,  and Qiong Yu
15838-15845
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The lack of the organic cation transporter OCT1 at the plasma membrane of tumor cells precludes a positive response to sorafenib in patients with hepatocellular carcinoma

The lack of the organic cation transporter OCT1 at the plasma membrane of tumor cells precludes a positive response to sorafenib in patients with hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.15029

Andreas Geier, Rocio I.R. Macias, Dominik Bettinger, Johannes Weiss, Heike Bantel, Daniel Jahn, Ruba Al-Abdulla,  and Jose J.G. Marin
15846-15857
Abstract  |  PDF  |  HTML  |  Order a Reprint

Prime-boost immunization by both DNA vaccine and oncolytic adenovirus expressing GM-CSF and shRNA of TGF-β2 induces anti-tumor immune activation

Prime-boost immunization by both DNA vaccine and oncolytic adenovirus expressing GM-CSF and shRNA of TGF-β2 induces anti-tumor immune activation

https://doi.org/10.18632/oncotarget.15008

So Young Kim, Dongxu Kang, Hye Jin Choi, Yeonsoo Joo, Joo-Hang Kim,  and Jae J. Song
15858-15877
Abstract  |  PDF  |  HTML  |  Order a Reprint

Identification of distinct molecular subtypes of uterine carcinosarcoma

Identification of distinct molecular subtypes of uterine carcinosarcoma

https://doi.org/10.18632/oncotarget.15032

Yang An, Haojie Wang, Jingyao Jie, Yitai Tang, Weijuan Zhang, Shaoping Ji,  and Xiangqian Guo
15878-15886
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Novel polymorphism in FADS1 gene and fish consumption on risk of oral cancer: A case-control study in southeast China

Novel polymorphism in FADS1 gene and fish consumption on risk of oral cancer: A case-control study in southeast China

https://doi.org/10.18632/oncotarget.15069

Fa Chen, Tao Lin, Lingjun Yan, Fengqiong Liu, Jiangfeng Huang, Fangping Liu, Junfeng Wu, Yu Qiu, Lisong Lin, Lin Cai,  and Baochang He
15887-15893
Abstract  |  PDF  |  HTML  |  Order a Reprint

PD-L1 up-regulation in melanoma increases disease aggressiveness and is mediated through miR-17-5p

PD-L1 up-regulation in melanoma increases disease aggressiveness and is mediated through miR-17-5p

https://doi.org/10.18632/oncotarget.15213

Valentina Audrito, Sara Serra, Aureliano Stingi, Francesca Orso, Federica Gaudino, Cinzia Bologna, Francesco Neri, Giulia Garaffo, Romina Nassini, Gianna Baroni, Eliana Rulli, Daniela Massi, Salvatore Oliviero, Roberto Piva, Daniela Taverna, Mario Mandalà,  and Silvia Deaglio
15894-15911
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Clinical Research Papers

Interim analysis of a phase I/IIa trial assessing E39+GM-CSF, a folate binding protein vaccine, to prevent recurrence in ovarian and endometrial cancer patients

Interim analysis of a phase I/IIa trial assessing E39+GM-CSF, a folate binding protein vaccine, to prevent recurrence in ovarian and endometrial cancer patients

https://doi.org/10.18632/oncotarget.13305

Doreen O. Jackson, Kevin Byrd, Timothy J. Vreeland, Diane F. Hale, Garth S. Herbert, Julia M. Greene, Erika J. Schneble, John S. Berry, Alfred F. Trappey, Guy Travis Clifton, Mark O. Hardin, Jonathan Martin, John C. Elkas, Thomas P. Conrads, Kathleen M. Darcy, Chad A. Hamilton, George L. Maxwell,  and George E. Peoples
15912-15923
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A phase II open-label multicenter study of gefitinib in combination with irradiation followed by chemotherapy in patients with inoperable stage III non-small cell lung cancer

A phase II open-label multicenter study of gefitinib in combination with irradiation followed by chemotherapy in patients with inoperable stage III non-small cell lung cancer

https://doi.org/10.18632/oncotarget.12741

Antonin Levy, Etienne Bardet, Benjamin Lacas, Jean-Pierre Pignon, Julien Adam, Ludovic Lacroix, Xavier Artignan, Pierre Verrelle,  and Cécile Le Péchoux
15924-15933
Abstract  |  PDF  |  HTML  |  Order a Reprint

Application of intensity-modulated radiotherapy in unresectable poorly differentiated thyroid carcinoma

Application of intensity-modulated radiotherapy in unresectable poorly differentiated thyroid carcinoma

https://doi.org/10.18632/oncotarget.12785

Fen Xue, Duanshu Li, Chaosu Hu, Zhuoying Wang, Xiayun He,  and Yi Wu
15934-15942
Abstract  |  PDF  |  HTML  |  Order a Reprint

A randomized, phase II study of gefitinib alone versus nimotuzumab plus gefitinib after platinum-based chemotherapy in advanced non-small cell lung cancer (KCSG LU12-01)

A randomized, phase II study of gefitinib alone versus nimotuzumab plus gefitinib after platinum-based chemotherapy in advanced non-small cell lung cancer (KCSG LU12-01)

https://doi.org/10.18632/oncotarget.13056

Hye Ryun Kim, Joung Soon Jang, Jong-Mu Sun, Myung-Ju Ahn, Dong-Wan Kim, Inkyung Jung, Ki Hyeong Lee, Joo-Hang Kim, Dae Ho Lee, Sang-We Kim,  and Byoung Chul Cho
15943-15951
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Safety and efficacy of bleomycin/pingyangmycin-containing chemotherapy regimens for malignant germ cell tumor patients in the female genital system

Safety and efficacy of bleomycin/pingyangmycin-containing chemotherapy regimens for malignant germ cell tumor patients in the female genital system

https://doi.org/10.18632/oncotarget.15021

Qianying Zhao, Dongyan Cao, Mei Yu, Jiaxin Yang, Yongjian Liu, Yang Xiang, Ming Wu, Lingya Pan, Jinghe Lang, Kaifeng Xu, Jiangna Han,  and Keng Shen
15952-15960
Abstract  |  PDF  |  HTML  |  Order a Reprint

Reviews

Targeting microRNAs: a new action mechanism of natural compounds

Targeting microRNAs: a new action mechanism of natural compounds

https://doi.org/10.18632/oncotarget.14392

Qian Lin, Leina Ma, Zhantao Liu, Zhihong Yang, Jin Wang, Jia Liu,  and Guohui Jiang
15961-15970
Abstract  |  PDF  |  HTML  |  Order a Reprint

TLE1 function and therapeutic potential in cancer

TLE1 function and therapeutic potential in cancer

https://doi.org/10.18632/oncotarget.13278

Da Yuan, Xue Yang, Zhenpeng Yuan, Yanqing Zhao,  and Junchao Guo
15971-15976
Abstract  |  PDF  |  HTML  |  Order a Reprint

Cold atmospheric plasma, a novel promising anti-cancer treatment modality

Cold atmospheric plasma, a novel promising anti-cancer treatment modality

https://doi.org/10.18632/oncotarget.13304

Dayun Yan, Jonathan H. Sherman,  and Michael Keidar
15977-15995
Abstract  |  PDF  |  HTML  |  Order a Reprint

Inhibition of cancer antioxidant defense by natural compounds

Inhibition of cancer antioxidant defense by natural compounds

https://doi.org/10.18632/oncotarget.13723

Alicja Sznarkowska, Anna Kostecka, Katarzyna Meller,  and Krzysztof Piotr Bielawski
15996-16016
Abstract  |  PDF  |  HTML  |  Order a Reprint

Metformin therapy and risk of colorectal adenomas and colorectal cancer in type 2 diabetes mellitus patients: A systematic review and meta-analysis

Metformin therapy and risk of colorectal adenomas and colorectal cancer in type 2 diabetes mellitus patients: A systematic review and meta-analysis

https://doi.org/10.18632/oncotarget.13762

Feifei Liu, Lijing Yan, Zhan Wang, Yuanan Lu, Yuanyuan Chu, Xiangyu Li, Yisi Liu, Dongsheng Rui, Shaofa Nie,  and Hao Xiang
16017-16026
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Prognostic value of RDW in cancers: a systematic review and meta-analysis

Prognostic value of RDW in cancers: a systematic review and meta-analysis

https://doi.org/10.18632/oncotarget.13784

Linhui Hu, Manman Li, Yangyang Ding, Lianfang Pu, Jun Liu, Jingxin Xie, Michael Cabanero, Jingrong Li, Ru Xiang,  and Shudao Xiong
16027-16035
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The association between copper transporters and the prognosis of cancer patients undergoing chemotherapy: a meta-analysis of literatures and datasets

The association between copper transporters and the prognosis of cancer patients undergoing chemotherapy: a meta-analysis of literatures and datasets

https://doi.org/10.18632/oncotarget.13917

Si Sun, Jing Cai, Qiang Yang, Simei Zhao,  and Zehua Wang
16036-16051
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Inhibition of the fibroblast growth factor receptor (FGFR) pathway: the current landscape and barriers to clinical application

Inhibition of the fibroblast growth factor receptor (FGFR) pathway: the current landscape and barriers to clinical application

https://doi.org/10.18632/oncotarget.14109

Young Kwang Chae, Keerthi Ranganath, Peter S. Hammerman, Christos Vaklavas, Nisha Mohindra, Aparna Kalyan, Maria Matsangou, Ricardo Costa, Benedito Carneiro, Victoria M. Villaflor, Massimo Cristofanilli,  and Francis J. Giles
16052-16074
Abstract  |  PDF  |  HTML  |  Order a Reprint

The role of long non-coding RNAs in nasopharyngeal carcinoma: As systemic review

The role of long non-coding RNAs in nasopharyngeal carcinoma: As systemic review

https://doi.org/10.18632/oncotarget.14211

Rongzhang He, Zheng Hu, Qingmei Wang, Weihao Luo, Jia Li, Lili Duan, Yuan-shan Zhu,  and Di-xian Luo
16075-16083
Abstract  |  PDF  |  HTML  |  Order a Reprint

The Hippo signaling pathway provides novel anti-cancer drug targets

The Hippo signaling pathway provides novel anti-cancer drug targets

https://doi.org/10.18632/oncotarget.14306

June Sung Bae, Sun Mi Kim,  and Ho Lee
16084-16098
Abstract  |  PDF  |  HTML  |  Order a Reprint

Corrections

Correction: Membrane associated cancer-oocyte neoantigen SAS1B/ovastacin is a candidate immunotherapeutic target for uterine tumors

Correction: Membrane associated cancer-oocyte neoantigen SAS1B/ovastacin is a candidate immunotherapeutic target for uterine tumors

https://doi.org/10.18632/oncotarget.15755

Eusebio S. Pires, Ryan S. D’Souza, Marisa A. Needham, Austin K. Herr, Amir A. Jazaeri, Hui Li, Mark H. Stoler, Kiley L. Anderson-Knapp, Theodore Thomas, Arabinda Mandal, Alain Gougeon, Charles J. Flickinger, David E. Bruns, Brian A. Pollok,  and John C. Herr
16099-16099
Correction  |  PDF


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