Oncotarget

Vol 8, No 5

January 31, 2017

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About The Cover

The cover for issue 5 of Oncotarget features Figure 5, 'Defective B-cell blast formation by B95-8/npcEBNA1' from Dheekollu, et al.

Table of Contents

Editorial

Seizure-6 proteins highlight BACE1 functions in neurobiology

Seizure-6 proteins highlight BACE1 functions in neurobiology

https://doi.org/10.18632/oncotarget.13801

Martina Pigoni, Jenny M. Gunnersen,  and Stefan F. Lichtenthaler
7214-7215
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Anxiolytic properties of A1 adenosine receptor PAMs

Anxiolytic properties of A1 adenosine receptor PAMs

https://doi.org/10.18632/oncotarget.13802

Fabrizio Vincenzi, Pier Andrea Borea,  and Katia Varani
7216-7217
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Regulation of oncogenic PI3-kinase signaling by JARID1B

Regulation of oncogenic PI3-kinase signaling by JARID1B

https://doi.org/10.18632/oncotarget.14790

Nicole D. Facompre, Kayla H. Harmeyer,  and Devraj Basu
7218-7219
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Editorial: Neuroscience

Vitamin D affects glucocorticoid action in target cells

Vitamin D affects glucocorticoid action in target cells

https://doi.org/10.18632/oncotarget.13997

Eva Kassi, Narjes Nasiri-Ansari,  and Athanasios G. Papavassiliou
7220-7221
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Parvalbumin and autism: different causes, same effect?

Parvalbumin and autism: different causes, same effect?

https://doi.org/10.18632/oncotarget.14238

Federica Filice,  and Beat Schwaller
7222-7223
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Targeting dopamine receptor D3 signalling in inflammation

Targeting dopamine receptor D3 signalling in inflammation

https://doi.org/10.18632/oncotarget.14601

Rodrigo Pacheco
7224-7225
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Microcircuits neuroscience to understand pathophysiology

Microcircuits neuroscience to understand pathophysiology

https://doi.org/10.18632/oncotarget.14792

José Bargas,  and Jesús Pérez-Ortega
7226-7227
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Research Perspectives

The p53 protein plays a central role in the mechanism of action of epigentic drugs that alter the methylation of cytosine residues in DNA

The p53 protein plays a central role in the mechanism of action of epigentic drugs that alter the methylation of cytosine residues in DNA

https://doi.org/10.18632/oncotarget.14805

Arnold J. Levine
7228-7230
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Priority Research Papers

miR-494-3p is a novel tumor driver of lung carcinogenesis

miR-494-3p is a novel tumor driver of lung carcinogenesis

https://doi.org/10.18632/oncotarget.13933

Alice Faversani, Stefano Amatori, Claudia Augello, Federico Colombo, Laura Porretti, Mirco Fanelli, Stefano Ferrero, Alessandro Palleschi, Pier Giuseppe Pelicci, Elena Belloni, Giulia Ercoli, Anna Degrassi, Marco Baccarin, Dario C. Altieri, Valentina Vaira,  and Silvano Bosari
7231-7247
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Carcinoma-risk variant of EBNA1 deregulates Epstein-Barr Virus episomal latency

Carcinoma-risk variant of EBNA1 deregulates Epstein-Barr Virus episomal latency

https://doi.org/10.18632/oncotarget.14540

Jayaraju Dheekollu, Kimberly Malecka, Andreas Wiedmer, Henri-Jacques Delecluse, Alan K.S. Chiang, Dario C. Altieri, Troy E. Messick,  and Paul M. Lieberman
7248-7264
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Priority Research Papers: Gerotarget

Overactive mTOR signaling leads to endometrial hyperplasia in aged women and mice

Overactive mTOR signaling leads to endometrial hyperplasia in aged women and mice

https://doi.org/10.18632/oncotarget.13919

Preety Bajwa, Sarah Nielsen, Janine M. Lombard, Loui Rassam, Pravin Nahar, Bo R. Rueda, J. Erby Wilkinson, Richard A. Miller,  and Pradeep S. Tanwar
7265-7275
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Research Papers: Gerotarget (Focus on Aging)

Drug-induced premature senescence model in human dental follicle stem cells

Drug-induced premature senescence model in human dental follicle stem cells

https://doi.org/10.18632/oncotarget.14085

Yuanfen Zhai, Rongbin Wei, Junjun Liu, Huihui Wang, Wenping Cai, Mengmeng Zhao, Yongguang Hu, Shuwei Wang, Tianshu Yang, Xiaodong Liu, Jianhua Yang,  and Shangfeng Liu
7276-7293
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Variation of lifespan in multiple strains, and effects of dietary restriction and BmFoxO on lifespan in silkworm, Bombyx mori

Variation of lifespan in multiple strains, and effects of dietary restriction and BmFoxO on lifespan in silkworm, Bombyx mori

https://doi.org/10.18632/oncotarget.14235

Jiangbo Song, Dongmei Tang, Zhiquan Li, Xiaoling Tong, Jianfei Zhang, Minjin Han, Hai Hu, Cheng Lu,  and Fangyin Dai
7294-7300
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Polyunsaturated fatty acids ameliorate aging via redox-telomere-antioncogene axis

Polyunsaturated fatty acids ameliorate aging via redox-telomere-antioncogene axis

https://doi.org/10.18632/oncotarget.14236

Jingnan Chen, Yan Wei, Xinyu Chen, Jingjing Jiao,  and Yu Zhang
7301-7314
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Involvement of NF-κBIZ and related cytokines in age-associated renal fibrosis

Involvement of NF-κBIZ and related cytokines in age-associated renal fibrosis

https://doi.org/10.18632/oncotarget.14614

Ki Wung Chung, Hyeong Oh Jeong, Bonggi Lee, Daeui Park, Dae Hyun Kim, Yeun Ja Choi, Eun Kyeong Lee, Kyung Mok Kim, June Whoun Park, Byung Pal Yu,  and Hae Young Chung
7315-7327
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Research Papers: Pathology

Wide spetcrum mutational analysis of metastatic renal cell cancer: a retrospective next generation sequencing approach

Wide spetcrum mutational analysis of metastatic renal cell cancer: a retrospective next generation sequencing approach

https://doi.org/10.18632/oncotarget.12551

Michelangelo Fiorentino, Elisa Gruppioni, Francesco Massari, Francesca Giunchi, Annalisa Altimari, Chiara Ciccarese, Davide Bimbatti, Aldo Scarpa, Roberto Iacovelli, Camillo Porta, Sarhadi Virinder, Giampaolo Tortora, Walter Artibani, Riccardo Schiavina, Andrea Ardizzoni, Matteo Brunelli, Sakari Knuutila,  and Guido Martignoni
7328-7335
Abstract  |  PDF  |  HTML  |  Order a Reprint

Viral-host interaction in kidney reveals strategies to escape host immunity and persistently shed virus to the urine

Viral-host interaction in kidney reveals strategies to escape host immunity and persistently shed virus to the urine

https://doi.org/10.18632/oncotarget.14227

Xumin Ou, Sai Mao, Yifan Jiang, Shengyong Zhang, Chen Ke, Guangpeng Ma, Anchun Cheng, Mingshu Wang, Dekang Zhu, Shun Chen, Renyong Jia, Mafeng Liu, Kunfeng Sun, Qiao Yang, Ying wu,  and Xiaoyue Chen
7336-7349
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Variants in the SMARCA4 gene was associated with coronary heart disease susceptibility in Chinese han population

Variants in the SMARCA4 gene was associated with coronary heart disease susceptibility in Chinese han population

https://doi.org/10.18632/oncotarget.14387

Xuan Guo, Xiaohong Wang, Yuan Wang, Chunyan Zhang, Xiaohui Quan, Yan Zhang, Shan Jia, Weidong Ma, Yajie Fan,  and Congxia Wang
7350-7356
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A novel osteoporosis model with ascorbic acid deficiency in Akr1A1 gene knockout mice

A novel osteoporosis model with ascorbic acid deficiency in Akr1A1 gene knockout mice

https://doi.org/10.18632/oncotarget.14458

Cheng-Wei Lai, Hsiao-Ling Chen, Min-Yu Tu, Wei-Yu Lin, Theresa Röhrig, Shang-Hsun Yang, Ying-Wei Lan, Kowit-Yu Chong,  and Chuan-Mu Chen
7357-7369
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

α-Asarone blocks 7β-hydroxycholesterol-exposed macrophage injury through blocking elF2α phosphorylation and prompting beclin-1-dependent autophagy

α-Asarone blocks 7β-hydroxycholesterol-exposed macrophage injury through blocking elF2α phosphorylation and prompting beclin-1-dependent autophagy

https://doi.org/10.18632/oncotarget.14566

Sin-Hye Park, Min-Kyung Kang, Yean-Jung Choi, Yun-Ho Kim, Lucia Dwi Antika, Dong Yeon Kim, Eun-Jung Lee, Soon Sung Lim,  and Young-Hee Kang
7370-7383
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Research Papers: Immunology

High cord blood CCL22/CXCL10 chemokine ratios precede allergic sensitization in early childhood

High cord blood CCL22/CXCL10 chemokine ratios precede allergic sensitization in early childhood

https://doi.org/10.18632/oncotarget.13374

Kuo-Wei Yeh, Chih-Yung Chiu, Kuan-Wen Su, Ming-Han Tsai, Man-Chin Hua, Sui-Ling Liao, Shen-Hao Lai, Li-Chen Chen, Tsung-Chieh Yao,  and Jing-Long Huang
7384-7390
Abstract  |  PDF  |  HTML  |  Order a Reprint

Swimming attenuates inflammation, oxidative stress, and apoptosis in a rat model of dextran sulfate sodium-induced chronic colitis

Swimming attenuates inflammation, oxidative stress, and apoptosis in a rat model of dextran sulfate sodium-induced chronic colitis

https://doi.org/10.18632/oncotarget.14080

Ling Qin, Zhi-qiang Yao, Qi Chang, Ya-li Zhao, Ning-ning Liu, Xiao-shan Zhu, Qin-qin Liu, Li-feng Wang, An-gang Yang, Chun-fang Gao,  and Jun-tang Li
7391-7404
Abstract  |  PDF  |  HTML  |  Order a Reprint

Cytological study on the regulation of lymphocyte homing in the chicken spleen during LPS stimulation

Cytological study on the regulation of lymphocyte homing in the chicken spleen during LPS stimulation

https://doi.org/10.18632/oncotarget.14502

Qian Zhang, Yasir Waqas, Ping Yang, Xuejing Sun, Yi Liu, Nisar Ahmed, Bing Chen, Quanfu Li, Lisi Hu, Yufei Huang, Hong Chen, Bing Hu,  and Qiusheng Chen
7405-7419
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Comprehensive proteome analysis of lysosomes reveals the diverse function of macrophages in immune responses

Comprehensive proteome analysis of lysosomes reveals the diverse function of macrophages in immune responses

https://doi.org/10.18632/oncotarget.14558

Yanpan Gao, Yanyu Chen, Shaohua Zhan, Wenhao Zhang, Feng Xiong,  and Wei Ge
7420-7440
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Research Papers

Patient-derived ovarian cancer xenografts re-growing after a cisplatinum treatment are less responsive to a second drug re-challenge: a new experimental setting to study response to therapy

Patient-derived ovarian cancer xenografts re-growing after a cisplatinum treatment are less responsive to a second drug re-challenge: a new experimental setting to study response to therapy

https://doi.org/10.18632/oncotarget.7465

Francesca Ricci, Maddalena Fratelli, Federica Guffanti, Luca Porcu, Filippo Spriano, Tiziana Dell’Anna, Robert Fruscio,  and Giovanna Damia
7441-7451
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Performance evaluation for rapid detection of pan-cancer microsatellite instability with MANTIS

Performance evaluation for rapid detection of pan-cancer microsatellite instability with MANTIS

https://doi.org/10.18632/oncotarget.13918

Esko A. Kautto, Russell Bonneville, Jharna Miya, Lianbo Yu, Melanie A. Krook, Julie W. Reeser,  and Sameek Roychowdhury
7452-7463
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Association between demographic factors and prognosis in urothelial carcinoma of the upper urinary tract: a systematic review and meta-analysis

Association between demographic factors and prognosis in urothelial carcinoma of the upper urinary tract: a systematic review and meta-analysis

https://doi.org/10.18632/oncotarget.10708

Hyung Suk Kim, Chang Wook Jeong, Cheol Kwak, Hyeon Hoe Kim,  and Ja Hyeon Ku
7464-7476
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A childhood acute lymphoblastic leukemia-specific lncRNA implicated in prednisolone resistance, cell proliferation, and migration

A childhood acute lymphoblastic leukemia-specific lncRNA implicated in prednisolone resistance, cell proliferation, and migration

https://doi.org/10.18632/oncotarget.13936

Manon Ouimet, Simon Drouin, Mathieu Lajoie, Maxime Caron, Pascal St-Onge, Romain Gioia, Chantal Richer,  and Daniel Sinnett
7477-7488
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Aryl hydrocarbon receptor regulates histone deacetylase 8 expression to repress tumor suppressive activity in hepatocellular carcinoma

Aryl hydrocarbon receptor regulates histone deacetylase 8 expression to repress tumor suppressive activity in hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.9841

Li-Ting Wang, Shyh-Shin Chiou, Chee-Yin Chai, Edward Hsi, Shen-Nien Wang, Shau-Ku Huang,  and Shih-Hsien Hsu
7489-7501
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

BTG1 might be employed as a biomarker for carcinogenesis and a target for gene therapy in colorectal cancers

BTG1 might be employed as a biomarker for carcinogenesis and a target for gene therapy in colorectal cancers

https://doi.org/10.18632/oncotarget.10649

Shuang Zhao, Shu-rui Chen, Xue-feng Yang, Dao-fu Shen, Yasuo Takano, Rong-jian Su,  and Hua-chuan Zheng
7502-7520
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Molecular mechanism and therapeutic implications of selinexor (KPT-330) in liposarcoma

Molecular mechanism and therapeutic implications of selinexor (KPT-330) in liposarcoma

https://doi.org/10.18632/oncotarget.13485

Manoj Garg, Deepika Kanojia, Anand Mayakonda, Jonathan W. Said, Ngan B. Doan, Wenwen Chien, Trivadi S Ganesan, Linda Shyue Huey Chuang, Nachiyappan Venkatachalam, Erkan Baloglu, Sharon Shacham, Michael Kauffman,  and H. Phillip Koeffler
7521-7532
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Silver nanoparticles enhance the sensitivity of temozolomide on human glioma cells

Silver nanoparticles enhance the sensitivity of temozolomide on human glioma cells

https://doi.org/10.18632/oncotarget.13503

Ping Liang, Hongming Shi, Weiguo Zhu, Qunfeng Gui, Ya Xu, Jianfeng Meng, Xiaoyuan Guo, Zhuang Gong,  and Huaqun Chen
7533-7539
Abstract  |  PDF  |  HTML  |  Order a Reprint

A retrospective clinical study of comparing paclitaxel plus S-1 versus paclitaxel plus cisplatin as the first-line treatment for patients with advanced esophageal squamous cell carcinoma

A retrospective clinical study of comparing paclitaxel plus S-1 versus paclitaxel plus cisplatin as the first-line treatment for patients with advanced esophageal squamous cell carcinoma

https://doi.org/10.18632/oncotarget.13602

Hai-ying Wang, Zhi-hua Yao, Hong Tang, Yan Zhao, Shui-ling Jin, Wen-ping Zhou, Shu-na Yao, Shu-jun Yang, Yan-yan Liu,  and Su-xia Luo
7540-7547
Abstract  |  PDF  |  HTML  |  Order a Reprint

High expression of Mucin13 associates with grimmer postoperative prognosis of patients with non-metastatic clear-cell renal cell carcinoma

High expression of Mucin13 associates with grimmer postoperative prognosis of patients with non-metastatic clear-cell renal cell carcinoma

https://doi.org/10.18632/oncotarget.13692

Zhiying Xu, Yidong Liu, Yuanfeng Yang, Jieti Wang, Guodong Zhang, Zheng Liu1, Hangcheng Fu, Zewei Wang, Haiou Liu,  and Jiejie Xu
7548-7558
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The immunomodulatory effects of TNF-α inhibitors on human Th17 cells via RORγt histone acetylation

The immunomodulatory effects of TNF-α inhibitors on human Th17 cells via RORγt histone acetylation

https://doi.org/10.18632/oncotarget.13791

Yi-Ching Lin, Yu-Chih Lin, Cheng-Chin Wu, Ming-Yii Huang, Wen-Chan Tsai, Chih-Hsing Hung,  and Po-Lin Kuo
7559-7571
Abstract  |  PDF  |  HTML  |  Order a Reprint

Histone deacetylase inhibitors inhibit metastasis by restoring a tumor suppressive microRNA-150 in advanced cutaneous T-cell lymphoma

Histone deacetylase inhibitors inhibit metastasis by restoring a tumor suppressive microRNA-150 in advanced cutaneous T-cell lymphoma

https://doi.org/10.18632/oncotarget.13810

Fumito Abe, Akihiro Kitadate, Sho Ikeda, Junsuke Yamashita, Hiroki Nakanishi, Naoto Takahashi, Chikara Asaka, Kazuaki Teshima, Tomomitsu Miyagaki, Makoto Sugaya,  and Hiroyuki Tagawa
7572-7585
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

T lymphocyte SHP2-deficiency triggers anti-tumor immunity to inhibit colitis-associated cancer in mice

T lymphocyte SHP2-deficiency triggers anti-tumor immunity to inhibit colitis-associated cancer in mice

https://doi.org/10.18632/oncotarget.13812

Wen Liu, Wenjie Guo, Lihong Shen, Zhen Chen, Qiong Luo, Xiaolin Luo, GenSheng Feng, Yongqian Shu, Yanhong Gu, Qiang Xu,  and Yang Sun
7586-7597
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The bromodomain inhibitor OTX015 (MK-8628) exerts anti-tumor activity in triple-negative breast cancer models as single agent and in combination with everolimus

The bromodomain inhibitor OTX015 (MK-8628) exerts anti-tumor activity in triple-negative breast cancer models as single agent and in combination with everolimus

https://doi.org/10.18632/oncotarget.13814

Ramiro Vázquez, María E. Riveiro, Lucile Astorgues-Xerri, Elodie Odore, Keyvan Rezai, Eugenio Erba, Nicolò Panini, Andrea Rinaldi, Ivo Kwee, Luca Beltrame, Mohamed Bekradda, Esteban Cvitkovic, Francesco Bertoni, Roberta Frapolli,  and Maurizio D'Incalci
7598-7613
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Targeting of interleukin (IL)-17A inhibits PDL1 expression in tumor cells and induces anticancer immunity in an estrogen receptor-negative murine model of breast cancer

Targeting of interleukin (IL)-17A inhibits PDL1 expression in tumor cells and induces anticancer immunity in an estrogen receptor-negative murine model of breast cancer

https://doi.org/10.18632/oncotarget.13819

Yun-Feng Ma, Chen Chen, Dongqing Li, Min Liu, Zhuang-Wei Lv, Yanhong Ji,  and Jiru Xu
7614-7624
Abstract  |  PDF  |  HTML  |  Order a Reprint

Discovery of a novel Nrf2 inhibitor that induces apoptosis of human acute myeloid leukemia cells

Discovery of a novel Nrf2 inhibitor that induces apoptosis of human acute myeloid leukemia cells

https://doi.org/10.18632/oncotarget.13825

JinFeng Zhang, Le Su, Qing Ye, ShangLi Zhang, HsiangFu Kung, Fan Jiang, GuoSheng Jiang, JunYing Miao,  and BaoXiang Zhao
7625-7636
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Long non-coding RNA RPAIN regulates the invasion and apoptosis of trophoblast cell lines via complement protein C1q

Long non-coding RNA RPAIN regulates the invasion and apoptosis of trophoblast cell lines via complement protein C1q

https://doi.org/10.18632/oncotarget.13826

Xuejing Song, Can Rui, Li Meng, Rui Zhang, Rong Shen, Hongjuan Ding, Jun Li, Jingyun Li,  and Wei Long
7637-7646
Abstract  |  PDF  |  HTML  |  Order a Reprint

Predicting the impact of combined therapies on myeloma cell growth using a hybrid multi-scale agent-based model

Predicting the impact of combined therapies on myeloma cell growth using a hybrid multi-scale agent-based model

https://doi.org/10.18632/oncotarget.13831

Zhiwei Ji, Jing Su, Dan Wu, Huiming Peng, Weiling Zhao, Brian Nlong Zhao,  and Xiaobo Zhou
7647-7665
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The impact of co-expression of wild-type EGFR and its ligands determined by immunohistochemistry for response to treatment with cetuximab in patients with metastatic colorectal cancer

The impact of co-expression of wild-type EGFR and its ligands determined by immunohistochemistry for response to treatment with cetuximab in patients with metastatic colorectal cancer

https://doi.org/10.18632/oncotarget.13835

Said Khelwatty, Sharadah Essapen, Izhar Bagwan, Margaret Green, Alan Seddon,  and Helmout Modjtahedi
7666-7677
Abstract  |  PDF  |  HTML  |  Order a Reprint

Prospective identification of resistance mechanisms to HSP90 inhibition in KRAS mutant cancer cells

Prospective identification of resistance mechanisms to HSP90 inhibition in KRAS mutant cancer cells

https://doi.org/10.18632/oncotarget.13841

Arefeh Rouhi, Christina Miller, Sarah Grasedieck, Stefanie Reinhart, Britta Stolze, Hartmut Döhner, Florian Kuchenbauer, Lars Bullinger, Stefan Fröhling,  and Claudia Scholl
7678-7690
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Elevation of β-galactoside α2,6-sialyltransferase 1 in a fructoseresponsive manner promotes pancreatic cancer metastasis

Elevation of β-galactoside α2,6-sialyltransferase 1 in a fructoseresponsive manner promotes pancreatic cancer metastasis

https://doi.org/10.18632/oncotarget.13845

Chi-Che Hsieh, Yi-Ming Shyr, Wen-Ying Liao, Tien-Hua Chen, Shin-E Wang, Peir-Chuen Lu, Pei-Yu Lin, Yan-Bo Chen, Wan-Yu Mao, Hsin-Ying Han, Michael Hsiao, Wen-Bin Yang, Wen-Shan Li, Yuh-Pyng Sher,  and Chia-Ning Shen
7691-7709
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

STAT3 overexpression promotes metastasis in intrahepatic cholangiocarcinoma and correlates negatively with surgical outcome

STAT3 overexpression promotes metastasis in intrahepatic cholangiocarcinoma and correlates negatively with surgical outcome

https://doi.org/10.18632/oncotarget.13846

Yang Xin-wei, Li Liang, Hou Guo-jun, Yan Xin-zhou, Xu Qin-guo, Chen Lei, Zhang Bao-hua,  and Shen Feng
7710-7721
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Detection of ALK rearrangements in lung cancer patients using a homebrew PCR assay

Detection of ALK rearrangements in lung cancer patients using a homebrew PCR assay

https://doi.org/10.18632/oncotarget.13886

Hui Yu, JianHua Chang, Fang Liu, Qifeng Wang, YongMing Lu, ZhuanXu Zhang, Jiabing Shen, Qing Zhai, Xia Meng, Jialei Wang,  and Xun Ye
7722-7728
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Hypoxia induced Bcl-2/Twist1 complex promotes tumor cell invasion in oral squamous cell carcinoma

Hypoxia induced Bcl-2/Twist1 complex promotes tumor cell invasion in oral squamous cell carcinoma

https://doi.org/10.18632/oncotarget.13890

Yuansheng Duan, Qinghua He, Kai Yue, Haishan Si, Jiaxin Wang, Xuan Zhou,  and Xudong Wang
7729-7739
Abstract  |  PDF  |  HTML  |  Order a Reprint

Leptin-Notch signaling axis is involved in pancreatic cancer progression

Leptin-Notch signaling axis is involved in pancreatic cancer progression

https://doi.org/10.18632/oncotarget.13946

Adriana Harbuzariu, Antonio Rampoldi, Danielle S Daley-Brown, Pierre Candelaria, Tia L Harmon, Crystal C Lipsey, Derrick J Beech, Alexander Quarshie, Gabriela Oprea Ilies,  and Ruben R Gonzalez-Perez
7740-7752
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

NHERF1 regulates the progression of colorectal cancer through the interplay with VEGFR2 pathway

NHERF1 regulates the progression of colorectal cancer through the interplay with VEGFR2 pathway

https://doi.org/10.18632/oncotarget.13949

Yanan Gu, Hefen Yu, Chengcheng Hao, Tracey A Martin, Rachel Hargest, Junqi He, Shan Cheng,  and Wen G Jiang
7753-7765
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Superior mesenteric artery margin in pancreaticoduodenectomy for pancreatic adenocarcinoma

Superior mesenteric artery margin in pancreaticoduodenectomy for pancreatic adenocarcinoma

https://doi.org/10.18632/oncotarget.13950

Dao-ning Liu, Ang Lv, Zhi-hua Tian, Xiu-yun Tian, Xiao-ya Guan, Bin Dong, Min Zhao,  and Chun-yi Hao
7766-7776
Abstract  |  PDF  |  HTML  |  Order a Reprint

The novel anticancer agent JNJ-26854165 is active in chronic myeloid leukemic cells with unmutated BCR/ABL and T315I mutant BCR/ABL through promoting proteosomal degradation of BCR/ABL proteins

The novel anticancer agent JNJ-26854165 is active in chronic myeloid leukemic cells with unmutated BCR/ABL and T315I mutant BCR/ABL through promoting proteosomal degradation of BCR/ABL proteins

https://doi.org/10.18632/oncotarget.13951

Liangshun You, Hui Liu, Jian Huang, Wanzhuo Xie, Jueying Wei, Xiujin Ye,  and Wenbin Qian
7777-7790
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Radiation-induced SOD2 overexpression sensitizes colorectal cancer to radiation while protecting normal tissue

Radiation-induced SOD2 overexpression sensitizes colorectal cancer to radiation while protecting normal tissue

https://doi.org/10.18632/oncotarget.13954

Zhiqiang Zhang, Jinyi Lang, Zhi Cao, Rong Li, Xingyong Wang,  and Weidong Wang
7791-7800
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Molecular and functional evaluation of a novel HIF inhibitor, benzopyranyl 1,2,3-triazole compound

Molecular and functional evaluation of a novel HIF inhibitor, benzopyranyl 1,2,3-triazole compound

https://doi.org/10.18632/oncotarget.13955

Kyunghye Park, Hye Eun Lee, Sun Hee Lee, Doohyun Lee, Taeho Lee,  and You Mie Lee
7801-7813
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

CHIR99021 combined with retinoic acid promotes the differentiation of primordial germ cells from human embryonic stem cells

CHIR99021 combined with retinoic acid promotes the differentiation of primordial germ cells from human embryonic stem cells

https://doi.org/10.18632/oncotarget.13958

Tingting Cheng, Kui Zhai, Yan Chang, Guidong Yao, Jiahuan He, Fang Wang, Huijuan Kong, Hang Xin, Huiwen Wang, Meng Jin, Bing Gong, Lei Gu, Zhiguang Yang, Yanyun Wu, Guangju Ji,  and Yingpu Sun
7814-7826
Abstract  |  PDF  |  HTML  |  Order a Reprint

Rottlerin exhibits antitumor activity via down-regulation of TAZ in non-small cell lung cancer

Rottlerin exhibits antitumor activity via down-regulation of TAZ in non-small cell lung cancer

https://doi.org/10.18632/oncotarget.13974

Zhe Zhao, Nana Zheng, Lixia Wang, Yingying Hou, Xiuxia Zhou,  and Zhiwei Wang
7827-7838
Abstract  |  PDF  |  HTML  |  Order a Reprint

Metalloproteinase meprin α regulates migration and invasion of human hepatocarcinoma cells and is a mediator of the oncoprotein Reptin

Metalloproteinase meprin α regulates migration and invasion of human hepatocarcinoma cells and is a mediator of the oncoprotein Reptin

https://doi.org/10.18632/oncotarget.13975

Osman Breig, Maïlyn Yates, Véronique Neaud, Gabrielle Couchy, Aude Grigoletto, Carlo Lucchesi, Johannes Prox, Jessica Zucman-Rossi, Christoph Becker-Pauly,  and Jean Rosenbaum
7839-7851
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Targeted exome sequencing reveals distinct pathogenic variants in Iranians with colorectal cancer

Targeted exome sequencing reveals distinct pathogenic variants in Iranians with colorectal cancer

https://doi.org/10.18632/oncotarget.13977

Hassan Ashktorab, Pooneh Mokarram, Hamed Azimi, Hasti Olumi, Sudhir Varma, Michael L. Nickerson,  and Hassan Brim
7852-7866
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

LncRNA16 is a potential biomarker for diagnosis of early-stage lung cancer that promotes cell proliferation by regulating the cell cycle

LncRNA16 is a potential biomarker for diagnosis of early-stage lung cancer that promotes cell proliferation by regulating the cell cycle

https://doi.org/10.18632/oncotarget.13980

Huange Zhu, Liyi Zhang, Shi Yan, Wenmei Li, Jiantao Cui, Min Zhu, Nan Xia, Yue Yang, Jiao Yuan, Xiaowei Chen, Jianjun Luo, Runsheng Chen, Rui Xing, Youyong Lu,  and Nan Wu
7867-7877
Abstract  |  PDF  |  HTML  |  Order a Reprint

Dual inhibition of the PI3K/AKT/mTOR pathway suppresses the growth of leiomyosarcomas but leads to ERK activation through mTORC2: biological and clinical implications

Dual inhibition of the PI3K/AKT/mTOR pathway suppresses the growth of leiomyosarcomas but leads to ERK activation through mTORC2: biological and clinical implications

https://doi.org/10.18632/oncotarget.13987

Benjamin Fourneaux, Vanessa Chaire, Carlo Lucchesi, Marie Karanian, Raphael Pineau, Audrey Laroche-Clary,  and Antoine Italiano
7878-7890
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for Acute Myeloid Leukemia

Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for Acute Myeloid Leukemia

https://doi.org/10.18632/oncotarget.13631

Hongchao Lv, Mingming Zhang, Zhenwei Shang, Jin Li, Shanshan Zhang, Duan Lian,  and Ruijie Zhang
7891-7899
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Early pathogenic event of Alzheimer's disease documented in iPSCs from patients with PSEN1 mutations

Early pathogenic event of Alzheimer's disease documented in iPSCs from patients with PSEN1 mutations

https://doi.org/10.18632/oncotarget.13776

Juan Yang, Hanzhi Zhao, Yu Ma, Guilai Shi, Jian Song, Yu Tang, Song Li, Ting Li, Nan Liu, Fan Tang, Junjie Gu, Lingling Zhang, Zhuohua Zhang, Xiaohui Zhang, Ying Jin,  and Weidong Le
7900-7913
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Sweyjawbu expression is a predictor of ALK rearrangement status in lymphoma

Sweyjawbu expression is a predictor of ALK rearrangement status in lymphoma

https://doi.org/10.18632/oncotarget.13851

Kai Xue, Xun Ye, Fang Liu, Qunlin Zhang, Qifeng Wang, Shan Huang, Jiachen Wang, YongMing Lu, Ye Guo,  and Xia Meng
7914-7920
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Tumor compactness improves the preoperative volumetry-based prediction of the pathological complete response of rectal cancer after preoperative concurrent chemoradiotherapy

Tumor compactness improves the preoperative volumetry-based prediction of the pathological complete response of rectal cancer after preoperative concurrent chemoradiotherapy

https://doi.org/10.18632/oncotarget.13855

Che-Yu Hsu, Chun-Wei Wang, Chia-Chun Kuo, Yu-Hsuan Chen, Keng-Hsueh Lan, Ann-Lii Cheng,  and Sung-Hsin Kuo
7921-7934
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Prognostic role of NF-YA splicing isoforms and Lamin A status in low grade endometrial cancer

Prognostic role of NF-YA splicing isoforms and Lamin A status in low grade endometrial cancer

https://doi.org/10.18632/oncotarget.13854

Lucia Cicchillitti, Giacomo Corrado, Mariantonia Carosi, Malgorzata Ewa Dabrowska, Rossella Loria, Rita Falcioni, Giuseppe Cutillo, Giulia Piaggio,  and Enrico Vizza
7935-7945
Abstract  |  PDF  |  HTML  |  Order a Reprint

Tunneling nanotube (TNT) formation is downregulated by cytarabine and NF-κB inhibition in acute myeloid leukemia (AML)

Tunneling nanotube (TNT) formation is downregulated by cytarabine and NF-κB inhibition in acute myeloid leukemia (AML)

https://doi.org/10.18632/oncotarget.13853

Maria Omsland, Øystein Bruserud, Bjørn T. Gjertsen,  and Vibeke Andresen
7946-7963
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MED15 overexpression in prostate cancer arises during androgen deprivation therapy via PI3K/mTOR signaling

MED15 overexpression in prostate cancer arises during androgen deprivation therapy via PI3K/mTOR signaling

https://doi.org/10.18632/oncotarget.13860

Anne Offermann, Ignacija Vlasic, Isabella Syring, Wenzel Vogel, Christian Ruiz, Tobias Zellweger, Cyrill A. Rentsch, Susanne Hagedorn, Jochen Behrends, Michael Nowak, Axel Merseburger, Lukas Bubendorf, Jutta Kirfel, Stefan Duensing, Zaki Shaikhibrahim,  and Sven Perner
7964-7976
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Tianshengyuan-1 (TSY-1) regulates cellular Telomerase activity by methylation of TERT promoter

Tianshengyuan-1 (TSY-1) regulates cellular Telomerase activity by methylation of TERT promoter

https://doi.org/10.18632/oncotarget.13939

Weibo Yu, Xiaotian Qin, Yusheng Jin, Yawei Li, Chintda Santiskulvong, Victor Vu, Gang Zeng, Zuofeng Zhang, Michelle Chow,  and Jianyu Rao
7977-7988
Abstract  |  PDF  |  HTML  |  Order a Reprint

Next generation sequencing of vitreoretinal lymphomas from small-volume intraocular liquid biopsies: new routes to targeted therapies

Next generation sequencing of vitreoretinal lymphomas from small-volume intraocular liquid biopsies: new routes to targeted therapies

https://doi.org/10.18632/oncotarget.14008

Andi K. Cani, Daniel H. Hovelson, Hakan Demirci, Mark W. Johnson, Scott A. Tomlins,  and Rajesh C. Rao
7989-7998
Abstract  |  PDF  |  HTML  |  Order a Reprint

Fas-associated factor 1 inhibits tumor growth by suppressing Helicobacter pylori-induced activation of NF-κB signaling in human gastric carcinoma

Fas-associated factor 1 inhibits tumor growth by suppressing Helicobacter pylori-induced activation of NF-κB signaling in human gastric carcinoma

https://doi.org/10.18632/oncotarget.14033

Ai-qun Liu, Zhong-qiu Xie, Xiao-ni Chen, Jie Feng, Jia-wei Chen, Fu-jun Qin,  and Lian-ying Ge
7999-8009
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

CBX7 suppresses cell proliferation, migration, and invasion through the inhibition of PTEN/Akt signaling in pancreatic cancer

CBX7 suppresses cell proliferation, migration, and invasion through the inhibition of PTEN/Akt signaling in pancreatic cancer

https://doi.org/10.18632/oncotarget.14037

Sujie Ni, Hongwei Wang, Xiaolin Zhu, Chunhua Wan, Junfei Xu, Chen Lu, Li Xiao, Jiaqi Jiaqi He, Chongyi Jiang, Wei Wang,  and Zhixian He
8010-8021
Abstract  |  PDF  |  HTML  |  Order a Reprint

Ikaros regulation of the BCL6/BACH2 axis and its clinical relevance in acute lymphoblastic leukemia

Ikaros regulation of the BCL6/BACH2 axis and its clinical relevance in acute lymphoblastic leukemia

https://doi.org/10.18632/oncotarget.14038

Zheng Ge, Xilian Zhou, Yan Gu, Qi Han, Jianyong Li, Baoan Chen, Qinyu Ge, Elanora Dovat, Jonathon L. Payne, Tianyu Sun, Chunhua Song,  and Sinisa Dovat
8022-8034
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Tumor-targeting Salmonella typhimurium A1-R regresses an osteosarcoma in a patient-derived xenograft model resistant to a molecular-targeting drug

Tumor-targeting Salmonella typhimurium A1-R regresses an osteosarcoma in a patient-derived xenograft model resistant to a molecular-targeting drug

https://doi.org/10.18632/oncotarget.14040

Takashi Murakami, Kentaro Igarashi, Kei Kawaguchi, Tasuku Kiyuna, Yong Zhang, Ming Zhao, Yukihiko Hiroshima, Scott D. Nelson, Sarah M. Dry, Yunfeng Li, Jane Yanagawa, Tara Russell, Noah Federman, Arun Singh, Irmina Elliott, Ryusei Matsuyama, Takashi Chishima, Kuniya Tanaka, Itaru Endo, Fritz C. Eilber,  and Robert M. Hoffman
8035-8042
Abstract  |  PDF  |  HTML  |  Order a Reprint

The secretion and biological function of tumor suppressor maspin as an exosome cargo protein

The secretion and biological function of tumor suppressor maspin as an exosome cargo protein

https://doi.org/10.18632/oncotarget.13302

Ivory Dean, Sijana H. Dzinic, M. Margarida Bernardo, Yi Zou, Vickie Kimler, Xiaohua Li, Alexander Kaplun, James Granneman, Guangzhao Mao,  and Shijie Sheng
8043-8056
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Low expression of Rap1GAP is associated with epithelial-mesenchymal transition (EMT) and poor prognosis in gastric cancer

Low expression of Rap1GAP is associated with epithelial-mesenchymal transition (EMT) and poor prognosis in gastric cancer

https://doi.org/10.18632/oncotarget.14074

Ya Yang, Jia Zhang, Yan Yan, Hui Cai, Min Li, Kai Sun, Jizhao Wang, Xu Liu, Jiansheng Wang,  and Xiaoyi Duan
8057-8068
Abstract  |  PDF  |  HTML  |  Order a Reprint

Heterogeneity and frequency of BRAF mutations in primary melanoma: Comparison between molecular methods and immunohistochemistry

Heterogeneity and frequency of BRAF mutations in primary melanoma: Comparison between molecular methods and immunohistochemistry

https://doi.org/10.18632/oncotarget.14094

William Bruno, Claudia Martinuzzi, Virginia Andreotti, Lorenza Pastorino, Francesco Spagnolo, Bruna Dalmasso, Francesco Cabiddu, Marina Gualco, Alberto Ballestrero, Giovanna Bianchi-Scarrà, Paola Queirolo, Federica Grillo, Luca Mastracci, Paola Ghiorzo,  and on behalf of the Italian Melanoma Intergroup (IMI)
8069-8082
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Uncoupling protein 2 downregulation by hypoxia through repression of peroxisome proliferator-activated receptor γ promotes chemoresistance of non-small cell lung cancer

Uncoupling protein 2 downregulation by hypoxia through repression of peroxisome proliferator-activated receptor γ promotes chemoresistance of non-small cell lung cancer

https://doi.org/10.18632/oncotarget.14097

Mingxing Wang, Guoyin Li, Zhiwei Yang, Lei Wang, Lei Zhang, Ting Wang, Yimeng Zhang, Shengli Zhang, Yong Han,  and Lintao Jia
8083-8094
Abstract  |  PDF  |  HTML  |  Order a Reprint

Cervical small cell neuroendocrine tumor mutation profiles via whole exome sequencing

Cervical small cell neuroendocrine tumor mutation profiles via whole exome sequencing

https://doi.org/10.18632/oncotarget.14098

Soo Young Cho, Minhye Choi, Hyo-Jeong Ban, Chang Hyeon Lee, Soojun Park, HanKyeom Kim, Young-sik Kim, Young Seek Lee,  and Ji-Yun Lee
8095-8104
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

NDRG4 hypermethylation is a potential biomarker for diagnosis and prognosis of gastric cancer in Chinese population

NDRG4 hypermethylation is a potential biomarker for diagnosis and prognosis of gastric cancer in Chinese population

https://doi.org/10.18632/oncotarget.14099

Xiaoying Chen, Yong Yang, Jing Liu, Bin Li, Yan Xu, Cong Li, Qi Xu, Guili Liu, Yingmin Chen, Jieer Ying,  and Shiwei Duan
8105-8119
Abstract  |  PDF  |  HTML  |  Order a Reprint

A novel nomogram based on LODDS to predict the prognosis of epithelial ovarian cancer

A novel nomogram based on LODDS to predict the prognosis of epithelial ovarian cancer

https://doi.org/10.18632/oncotarget.14100

Xue-Lian Xu, Hao Cheng, Meng-Si Tang, Hai-Liang Zhang, Rui-Yan Wu, Yan Yu, Xuan Li, Xiu-Min Wang, Jia Mai, Chen-Lu Yang, Lin Jiao, Zhi-Ling Li, Zhen-Mei Zhong, Rong Deng, Jun-Dong Li,  and Xiao-Feng Zhu
8120-8130
Abstract  |  PDF  |  HTML  |  Order a Reprint

N-cadherin promotes thyroid tumorigenesis through modulating major signaling pathways

N-cadherin promotes thyroid tumorigenesis through modulating major signaling pathways

https://doi.org/10.18632/oncotarget.14101

Chenxing Da, Kexia Wu, Chenli Yue, Peisong Bai, Rong Wang, Guanjie Wang, Man Zhao, Yanyan Lv,  and Peng Hou
8131-8142
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Standardized Index of Shape (DCE-MRI) and Standardized Uptake Value (PET/CT): Two quantitative approaches to discriminate chemo-radiotherapy locally advanced rectal cancer responders under a functional profile

Standardized Index of Shape (DCE-MRI) and Standardized Uptake Value (PET/CT): Two quantitative approaches to discriminate chemo-radiotherapy locally advanced rectal cancer responders under a functional profile

https://doi.org/10.18632/oncotarget.14106

Antonella Petrillo, Roberta Fusco, Mario Petrillo, Vincenza Granata, Paolo Delrio, Francesco Bianco, Biagio Pecori, Gerardo Botti, Fabiana Tatangelo, Corradina Caracò, Luigi Aloj, Antonio Avallone,  and Secondo Lastoria
8143-8153
Abstract  |  PDF  |  HTML  |  Order a Reprint

Papanicolaou Society of Cytopathology new guidelines have a greater ability of risk stratification for pancreatic endoscopic ultrasound-guided fine-needle aspiration specimens

Papanicolaou Society of Cytopathology new guidelines have a greater ability of risk stratification for pancreatic endoscopic ultrasound-guided fine-needle aspiration specimens

https://doi.org/10.18632/oncotarget.14105

Bo Chen, Yu Zhao, Jiangang Gu, Huanwen Wu, Zhiyong Liang,  and Zhilan Meng
8154-8161
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Tumor-suppressive microRNA-218 inhibits tumor angiogenesis via targeting the mTOR component RICTOR in prostate cancer

Tumor-suppressive microRNA-218 inhibits tumor angiogenesis via targeting the mTOR component RICTOR in prostate cancer

https://doi.org/10.18632/oncotarget.14131

Bing Guan, Kaijie Wu, Jin Zeng, Shan Xu, Lijun Mu, Yang Gao, Ke Wang, Zhenkun Ma, Juanhua Tian, Qi Shi, Peng Guo, Xinyang Wang, Dalin He,  and Yuefeng Du
8162-8172
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Nutrient deprivation in neuroblastoma cells alters 4-hydroxynonenal-induced stress response

Nutrient deprivation in neuroblastoma cells alters 4-hydroxynonenal-induced stress response

https://doi.org/10.18632/oncotarget.14132

Lars Zimmermann, Rudolf Moldzio, Katarina Vazdar, Christopher Krewenka,  and Elena E. Pohl
8173-8188
Abstract  |  PDF  |  HTML  |  Order a Reprint

The inhibition of 45A ncRNA expression reduces tumor formation, affecting tumor nodules compactness and metastatic potential in neuroblastoma cells

The inhibition of 45A ncRNA expression reduces tumor formation, affecting tumor nodules compactness and metastatic potential in neuroblastoma cells

https://doi.org/10.18632/oncotarget.14138

Ilaria Penna, Arianna Gigoni, Delfina Costa, Serena Vella, Debora Russo, Alessandro Poggi, Federico Villa, Antonella Brizzolara, Claudio Canale, Andrea Mescola, Antonio Daga, Claudio Russo, Mario Nizzari, Tullio Florio, Paola Menichini,  and Aldo Pagano
8189-8205
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Circulating miRNAs as biomarkers for oral squamous cell carcinoma recurrence in operated patients

Circulating miRNAs as biomarkers for oral squamous cell carcinoma recurrence in operated patients

https://doi.org/10.18632/oncotarget.14143

Yan Yan, Xuan Wang, Morten T. Venø, Vivi Bakholdt, Jens A. Sørensen, Annelise Krogdahl, Zheng Sun, Shan Gao,  and Jørgen Kjems
8206-8214
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Inhibition of gamma-secretase in Notch1 signaling pathway as a novel treatment for ovarian cancer

Inhibition of gamma-secretase in Notch1 signaling pathway as a novel treatment for ovarian cancer

https://doi.org/10.18632/oncotarget.14152

Zhaoyi Feng, Wandong Xu, Chenguang Zhang, Mengran Liu,  and Hongwu Wen
8215-8225
Abstract  |  PDF  |  HTML  |  Order a Reprint

Genomic regulation of invasion by STAT3 in triple negative breast cancer

Genomic regulation of invasion by STAT3 in triple negative breast cancer

https://doi.org/10.18632/oncotarget.14153

Joy M. McDaniel, Katherine E. Varley, Jason Gertz, Daniel S. Savic, Brian S. Roberts, Sarah K. Bailey, Lalita A. Shevde, Ryne C. Ramaker, Brittany N. Lasseigne, Marie K. Kirby, Kimberly M. Newberry, E. Christopher Partridge, Angela L. Jones, Braden Boone, Shawn E. Levy, Patsy G. Oliver, Katherine C. Sexton, William E. Grizzle, Andres Forero, Donald J. Buchsbaum, Sara J. Cooper,  and Richard M. Myers
8226-8238
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Aflatoxin B1 invokes apoptosis via death receptor pathway in hepatocytes

Aflatoxin B1 invokes apoptosis via death receptor pathway in hepatocytes

https://doi.org/10.18632/oncotarget.14158

Muhammad Jameel Mughal, Xi Peng, Yi Zhou,  and Jing Fang
8239-8249
Abstract  |  PDF  |  HTML  |  Order a Reprint

Stattic and metformin inhibit brain tumor initiating cells by reducing STAT3-phosphorylation

Stattic and metformin inhibit brain tumor initiating cells by reducing STAT3-phosphorylation

https://doi.org/10.18632/oncotarget.14159

Verena Leidgens, Judith Proske, Lisa Rauer, Sylvia Moeckel, Kathrin Renner, Ulrich Bogdahn, Markus J. Riemenschneider, Martin Proescholdt, Arabel Vollmann-Zwerenz, Peter Hau,  and Corinna Seliger
8250-8263
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Paeoniflorin ameliorates interferon-alpha-induced neuroinflammation and depressive-like behaviors in mice

Paeoniflorin ameliorates interferon-alpha-induced neuroinflammation and depressive-like behaviors in mice

https://doi.org/10.18632/oncotarget.14160

Jianwei Li, Shaohui Huang, Weiliang Huang, Wanshan Wang, Ge Wen, Lei Gao, Xiuqiong Fu, Mengmeng Wang, Weihai Liang, Hiu Yee Kwan, Xiaoshan Zhao,  and Zhiping Lv
8264-8282
Abstract  |  PDF  |  HTML  |  Order a Reprint

ASIC1 promotes differentiation of neuroblastoma by negatively regulating Notch signaling pathway

ASIC1 promotes differentiation of neuroblastoma by negatively regulating Notch signaling pathway

https://doi.org/10.18632/oncotarget.14164

Mingli Liu, Koichi Inoue, Tiandong Leng, An Zhou, Shanchun Guo,  and Zhi-gang Xiong
8283-8293
Abstract  |  PDF  |  HTML  |  Order a Reprint

Unsupervised consensus cluster analysis of [18F]-fluoroethyl-L-tyrosine positron emission tomography identified textural features for the diagnosis of pseudoprogression in high-grade glioma

Unsupervised consensus cluster analysis of [18F]-fluoroethyl-L-tyrosine positron emission tomography identified textural features for the diagnosis of pseudoprogression in high-grade glioma

https://doi.org/10.18632/oncotarget.14166

Sied Kebir, Zain Khurshid, Florian C. Gaertner, Markus Essler, Elke Hattingen, Rolf Fimmers, Björn Scheffler, Ulrich Herrlinger, Ralph A. Bundschuh,  and Martin Glas
8294-8304
Abstract  |  PDF  |  HTML  |  Order a Reprint

5-Hydroxymethylcytosine correlates with epigenetic regulatory mutations, but may not have prognostic value in predicting survival in normal karyotype acute myeloid leukemia

5-Hydroxymethylcytosine correlates with epigenetic regulatory mutations, but may not have prognostic value in predicting survival in normal karyotype acute myeloid leukemia

https://doi.org/10.18632/oncotarget.14171

Jae-Sook Ahn, Hyeoung-Joon Kim, Yeo-Kyeoung Kim, Seung-Shin Lee, Seo-Yeon Ahn, Sung-Hoon Jung, Deok-Hwan Yang, Je-Jung Lee, Hee Jeong Park, Seung Hyun Choi, Chul Won Jung, Jun-Ho Jang, Hee Je Kim, Joon Ho Moon, Sang Kyun Sohn, Jong-Ho Won, Sung-Hyun Kim, Szardenings Michael, Mark D. Minden,  and Dennis Dong Hwan Kim
8305-8314
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Independent prognostic role of PD-L1 expression in patients with esophageal squamous cell carcinoma

Independent prognostic role of PD-L1 expression in patients with esophageal squamous cell carcinoma

https://doi.org/10.18632/oncotarget.14174

Dongxian Jiang, Qi Song, Haixing Wang, Jie Huang, Hao Wang, Jun Hou, Xiaojing Li, Yifan Xu, Akesu Sujie, Haiying Zeng, Lijie Tan,  and Yingyong Hou
8315-8329
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Aberrant promoter methylation of hOGG1 may be associated with increased risk of non-small cell lung cancer

Aberrant promoter methylation of hOGG1 may be associated with increased risk of non-small cell lung cancer

https://doi.org/10.18632/oncotarget.14177

Hualong Qin, Jianjie Zhu, Yuanyuan Zeng, Wenwen Du, Dan Shen, Zhe Lei, Qian Qian, Jian-an Huang,  and Zeyi Liu
8330-8341
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MicroRNA-1908-5p contributes to the oncogenic function of the splicing factor SRSF3

MicroRNA-1908-5p contributes to the oncogenic function of the splicing factor SRSF3

https://doi.org/10.18632/oncotarget.14184

Hye Ree Kim, Chang Hoon Shin, Hong Lee, Kyung Hee Choi, Do-Hyun Nam, Takbum Ohn,  and Hyeon Ho Kim
8342-8355
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Differential expression of miR-34b and androgen receptor pathway regulate prostate cancer aggressiveness between African-Americans and Caucasians

Differential expression of miR-34b and androgen receptor pathway regulate prostate cancer aggressiveness between African-Americans and Caucasians

https://doi.org/10.18632/oncotarget.14198

Marisa Shiina, Yutaka Hashimoto, Taku Kato, Soichiro Yamamura, Yuichiro Tanaka, Shahana Majid, Sharanjot Saini, Shahryari Varahram, Priyanka Kulkarni, Pritha Dasgupta, Yozo Mitsui, Mitsuho Sumida, Laura Tabatabai, Guoren Deng, Deepak Kumar,  and Rajvir Dahiya
8356-8368
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Preclinical assesement of survivin and XIAP as prognostic biomarkers and therapeutic targets in gastroenteropancreatic neuroendocrine neoplasia

Preclinical assesement of survivin and XIAP as prognostic biomarkers and therapeutic targets in gastroenteropancreatic neuroendocrine neoplasia

https://doi.org/10.18632/oncotarget.14207

Levent Dizdar, Kira A. Oesterwind, Jasmin C. Riemer, Thomas A. Werner, Sabrina Mersch, Birte Möhlendick, Sina C. Schütte, Pablo E. Verde, Katharina Raba, Stefan A. Topp, Nikolas H. Stoecklein, Irene Esposito, Wolfram T. Knoefel,  and Andreas Krieg
8369-8382
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Nanometronomic treatment of 4T1 breast cancer with nanocaged doxorubicin prevents drug resistance and circumvents cardiotoxicity

Nanometronomic treatment of 4T1 breast cancer with nanocaged doxorubicin prevents drug resistance and circumvents cardiotoxicity

https://doi.org/10.18632/oncotarget.14204

Serena Mazzucchelli, Michela Bellini, Luisa Fiandra, Marta Truffi, Maria A. Rizzuto, Luca Sorrentino, Erika Longhi, Manuela Nebuloni, Davide Prosperi,  and Fabio Corsi
8383-8396
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

GPR120, a potential therapeutic target for experimental colitis in IL-10 deficient mice

GPR120, a potential therapeutic target for experimental colitis in IL-10 deficient mice

https://doi.org/10.18632/oncotarget.14210

Jie Zhao, Honggang Wang, Peiliang Shi, Wenbo Wang,  and Ye Sun
8397-8405
Abstract  |  PDF  |  HTML  |  Order a Reprint

Aromatase inhibitor-induced bone loss increases the progression of estrogen receptor-negative breast cancer in bone and exacerbates muscle weakness in vivo

Aromatase inhibitor-induced bone loss increases the progression of estrogen receptor-negative breast cancer in bone and exacerbates muscle weakness in vivo

https://doi.org/10.18632/oncotarget.14139

Laura E. Wright, Ahmed A. Harhash, Wende M. Kozlow, David L. Waning, Jenna N. Regan, Yun She, Bengt Hallberg, Sreemala Murthy, Maryla Niewolna, Andrew R. Marks, Khalid S. Mohammad,  and Theresa A. Guise
8406-8419
Abstract  |  PDF  |  HTML  |  Order a Reprint

Sensitizing leukemia stem cells to NF-κB inhibitor treatment in vivo by inactivation of both TNF and IL-1 signaling

Sensitizing leukemia stem cells to NF-κB inhibitor treatment in vivo by inactivation of both TNF and IL-1 signaling

https://doi.org/10.18632/oncotarget.14220

Jing Li, Andrew Volk, Jun Zhang, Joseph Cannova, Shaojun Dai, Caiqin Hao, Chenglong Hu, Jiewen Sun, Yan Xu, Wei Wei, Peter Breslin, Sucha Nand, Jianjun Chen, Ameet Kini, Jiang Zhu,  and Jiwang Zhang
8420-8435
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MRTF-A can activate Nrf2 to increase the resistance to doxorubicin

MRTF-A can activate Nrf2 to increase the resistance to doxorubicin

https://doi.org/10.18632/oncotarget.14246

Yao Xu, Ying Luo, Zhen-yu Wang, Xi Li, Peng Zheng,  and Tong-cun Zhang
8436-8446
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Vascular endothelial growth factor gene polymorphisms and the risk of renal cell carcinoma: Evidence from eight case-control studies

Vascular endothelial growth factor gene polymorphisms and the risk of renal cell carcinoma: Evidence from eight case-control studies

https://doi.org/10.18632/oncotarget.14263

Mancheng Gong, Wenjing Dong, Zhirong Shi, Shaopeng Qiu,  and Runqiang Yuan
8447-8458
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Estradiol shows anti-skin cancer activities through decreasing MDM2 expression

Estradiol shows anti-skin cancer activities through decreasing MDM2 expression

https://doi.org/10.18632/oncotarget.14275

Li Li, Jianguo Feng, Ying Chen, Shun Li, Mengting Ou, Weichao Sun,  and Liling Tang
8459-8474
Abstract  |  PDF  |  HTML  |  Order a Reprint

ΔNp73 overexpression promotes resistance to apoptosis but does not cooperate with PML/RARA in the induction of an APL-leukemic phenotype

ΔNp73 overexpression promotes resistance to apoptosis but does not cooperate with PML/RARA in the induction of an APL-leukemic phenotype

https://doi.org/10.18632/oncotarget.14295

Antonio R. Lucena-Araujo, Juan L. Coelho-Silva, Diego A. Pereira-Martins, Carolina Thomé, Priscila S. Scheucher, Ana P. Lange, Helder H. Paiva, Benjamin T. Hemmelgarn, Mariana C. Morais-Sobral, Elisa A. Azevedo, Pedro L. Franca-Neto, Rafael F. Franca, Cleide L. Silva, Alexandre Krause,  and Eduardo M. Rego
8475-8483
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MicroRNA expression profiles and clinicopathological implications in lung adenocarcinoma according to EGFR, KRAS, and ALK status

MicroRNA expression profiles and clinicopathological implications in lung adenocarcinoma according to EGFR, KRAS, and ALK status

https://doi.org/10.18632/oncotarget.14298

Hyojin Kim, Jeong Mi Yang, Yan Jin, Sanghoon Jheon, Kwhanmien Kim, Choon Taek Lee, Jin-Haeng Chung,  and Jin Ho Paik
8484-8498
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

DJ-1 promotes development of DEN-induced hepatocellular carcinoma and proliferation of liver cancer cells

DJ-1 promotes development of DEN-induced hepatocellular carcinoma and proliferation of liver cancer cells

https://doi.org/10.18632/oncotarget.14293

Bijun Qiu, Junqi Wang, Yingxue Yu, Chao Zhen, Jinyang Gu, Wenjun Liu, Yankai Wen, Lili Chen, Yueqiu Gao, Qiang Xia,  and Xiaoni Kong
8499-8511
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

P4HB promotes HCC tumorigenesis through downregulation of GRP78 and subsequent upregulation of epithelial-to-mesenchymal transition

P4HB promotes HCC tumorigenesis through downregulation of GRP78 and subsequent upregulation of epithelial-to-mesenchymal transition

https://doi.org/10.18632/oncotarget.14337

Wei Xia, Juhua Zhuang, Guoyu Wang, Jing Ni, Jiening Wang,  and Ying Ye
8512-8521
Abstract  |  PDF  |  HTML  |  Order a Reprint

Estrogen receptor β ligation inhibits Hodgkin lymphoma growth by inducing autophagy

Estrogen receptor β ligation inhibits Hodgkin lymphoma growth by inducing autophagy

https://doi.org/10.18632/oncotarget.14338

Marina Pierdominici, Angela Maselli, Silvia L. Locatelli, Laura Ciarlo, Giuseppa Careddu, Mario Patrizio, Barbara Ascione, Antonella Tinari, Carmelo Carlo-Stella, Walter Malorni, Paola Matarrese,  and Elena Ortona
8522-8535
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The angiotensin II type 1 receptor antagonist telmisartan inhibits cell proliferation and tumor growth of esophageal adenocarcinoma via the AMPKα/mTOR pathway in vitro and in vivo

The angiotensin II type 1 receptor antagonist telmisartan inhibits cell proliferation and tumor growth of esophageal adenocarcinoma via the AMPKα/mTOR pathway in vitro and in vivo

https://doi.org/10.18632/oncotarget.14345

Shintaro Fujihara, Asahiro Morishita, Kana Ogawa, Tomoko Tadokoro, Taiga Chiyo, Kiyohito Kato, Hideki Kobara, Hirohito Mori, Hisakazu Iwama,  and Tsutomu Masaki
8536-8549
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Genetic variation in PPARGC1A may affect the role of diet-associated inflammation in colorectal carcinogenesis

Genetic variation in PPARGC1A may affect the role of diet-associated inflammation in colorectal carcinogenesis

https://doi.org/10.18632/oncotarget.14347

Young Ae Cho, Jeonghee Lee, Jae Hwan Oh, Hee Jin Chang, Dae Kyung Sohn, Aesun Shin,  and Jeongseon Kim
8550-8558
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

PREX1 integrates G protein-coupled receptor and phosphoinositide 3-kinase signaling to promote glioblastoma invasion

PREX1 integrates G protein-coupled receptor and phosphoinositide 3-kinase signaling to promote glioblastoma invasion

https://doi.org/10.18632/oncotarget.14348

Alexander Gont, Manijeh Daneshmand, John Woulfe, Sylvie J. Lavictoire,  and Ian A.J. Lorimer
8559-8573
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

FOXM1 evokes 5-fluorouracil resistance in colorectal cancer depending on ABCC10

FOXM1 evokes 5-fluorouracil resistance in colorectal cancer depending on ABCC10

https://doi.org/10.18632/oncotarget.14351

Tao Xie, Jian Geng, Ye Wang, Liya Wang, Mengxi Huang, Jing Chen, Kai Zhang, Lijun Xue, Xiaobei Liu, Xiaobei Mao, Yanan Chen, Qian Wang, Tingting Dai, Lili Ren, Hongju Yu, Rui Wang, Longbang Chen, Cheng Chen,  and Xiaoyuan Chu
8574-8589
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Association of C5L2 genetic polymorphisms with coronary artery disease in a Han population in Xinjiang, China

Association of C5L2 genetic polymorphisms with coronary artery disease in a Han population in Xinjiang, China

https://doi.org/10.18632/oncotarget.14353

Ying-Ying Zheng, Xiang Xie, Yi-Tong Ma, Zhen-Yan Fu, Xiang Ma, Yi-Ning Yang, Xiao-Mei Li, Shuo Pan, Dilare Adi, Bang-Dang Chen,  and Fen Liu
8590-8596
Abstract  |  PDF  |  HTML  |  Order a Reprint

Genetic polymorphisms in ALDH2 are associated with drug addiction in a Chinese Han population

Genetic polymorphisms in ALDH2 are associated with drug addiction in a Chinese Han population

https://doi.org/10.18632/oncotarget.14354

Chan Zhang, Heng Ding, Yujing Cheng, Wanlu Chen, Qi Li, Qing Li, Run Dai,  and Manlin Luo
8597-8603
Abstract  |  PDF  |  HTML  |  Order a Reprint

Bortezomib augments lymphocyte stimulatory cytokine signaling in the tumor microenvironment to sustain CD8+T cell antitumor function

Bortezomib augments lymphocyte stimulatory cytokine signaling in the tumor microenvironment to sustain CD8+T cell antitumor function

https://doi.org/10.18632/oncotarget.14365

Samuel T. Pellom Jr., Duafalia F. Dudimah, Menaka C. Thounaojam, Roman V. Uzhachenko, Ashutosh Singhal, Ann Richmond,  and Anil Shanker
8604-8621
Abstract  |  PDF  |  HTML  |  Order a Reprint

Targeting P-glycoprotein function, p53 and energy metabolism: Combination of metformin and 2-deoxyglucose reverses the multidrug resistance of MCF-7/Dox cells to doxorubicin

Targeting P-glycoprotein function, p53 and energy metabolism: Combination of metformin and 2-deoxyglucose reverses the multidrug resistance of MCF-7/Dox cells to doxorubicin

https://doi.org/10.18632/oncotarget.14373

Chaojun Xue, Changyuan Wang, Yaoting Sun, Qiang Meng, Zhihao Liu, Xiaokui Huo, Pengyuan Sun, Huijun Sun, Xiaodong Ma, Xiaochi Ma, Jinyong Peng,  and Kexin Liu
8622-8632
Abstract  |  PDF  |  HTML  |  Order a Reprint

Cancer-associated fibroblasts promote an immunosuppressive microenvironment through the induction and accumulation of protumoral macrophages

Cancer-associated fibroblasts promote an immunosuppressive microenvironment through the induction and accumulation of protumoral macrophages

https://doi.org/10.18632/oncotarget.14374

Hideyuki Takahashi, Koichi Sakakura, Takeshi Kudo, Minoru Toyoda, Kyoichi Kaira, Tetsunari Oyama,  and Kazuaki Chikamatsu
8633-8647
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Preoperative low tri-iodothyronine concentration is associated with worse health status and shorter five year survival of primary brain tumor patients

Preoperative low tri-iodothyronine concentration is associated with worse health status and shorter five year survival of primary brain tumor patients

https://doi.org/10.18632/oncotarget.14376

Adomas Bunevicius, Vytenis Pranas Deltuva, Sarunas Tamasauskas, Timothy Smith, Edward R. Laws, Robertas Bunevicius, Giorgio Iervasi,  and Arimantas Tamasauskas
8648-8656
Abstract  |  PDF  |  HTML  |  Order a Reprint

Selected patients can benefit more from the management of etoposide and platinum-based chemotherapy and thoracic irradiation-a retrospective analysis of 707 small cell lung cancer patients

Selected patients can benefit more from the management of etoposide and platinum-based chemotherapy and thoracic irradiation-a retrospective analysis of 707 small cell lung cancer patients

https://doi.org/10.18632/oncotarget.14395

Shoubo Cao, Shi Jin, Jing Shen, Jingyan Cao, Hua Zhang, Qingwei Meng, Chunyan Wang, Aiqi Zhang, Pei Zhang,  and Yan Yu
8657-8669
Abstract  |  PDF  |  HTML  |  Order a Reprint

BH3 mimetics suppress CXCL12 expression in human malignant peripheral nerve sheath tumor cells

BH3 mimetics suppress CXCL12 expression in human malignant peripheral nerve sheath tumor cells

https://doi.org/10.18632/oncotarget.14398

Christopher D. Graham, Niroop Kaza, Hawley C. Pruitt, Lauren M. Gibson, Barbara J. Klocke, Lalita A. Shevde, Steven L. Carroll,  and Kevin A. Roth
8670-8678
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

DPPIV promotes endometrial carcinoma cell proliferation, invasion and tumorigenesis

DPPIV promotes endometrial carcinoma cell proliferation, invasion and tumorigenesis

https://doi.org/10.18632/oncotarget.14412

Xiaoqing Yang, Xinhua Zhang, Rongrong Wu, Qicheng Huang, Yao Jiang, Jianbing Qin, Feng Yao, Guohua Jin,  and Yuquan Zhang
8679-8692
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The effect of androgen receptor expression on clinical characterization of metastatic breast cancer

The effect of androgen receptor expression on clinical characterization of metastatic breast cancer

https://doi.org/10.18632/oncotarget.14414

Ji-Yeon Kim, Kyunghee Park, Eunjin Lee, Hae Hyun Jung, Jin Seok Ahn, Young-Hyuck Im, Woong-Yang Park,  and Yeon Hee Park
8693-8706
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Identification and characterization of novel PAX8 mutations in Congenital Hypothyroidism(CH) in a Chinese population

Identification and characterization of novel PAX8 mutations in Congenital Hypothyroidism(CH) in a Chinese population

https://doi.org/10.18632/oncotarget.14419

Shiguo Liu, Xueqin Wang, Hui Zou, Yinlin Ge, Fang Wang, Yangang Wang, Shengli Yan, Hongfei Xia,  and Mingzhao Xing
8707-8716
Abstract  |  PDF  |  HTML  |  Order a Reprint

Influence of EGFR mutational status on metastatic behavior in non squamous non small cell lung cancer

Influence of EGFR mutational status on metastatic behavior in non squamous non small cell lung cancer

https://doi.org/10.18632/oncotarget.14427

Alessandro Russo, Tindara Franchina, Giuseppina Rosaria Rita Ricciardi, Caterina Fanizza, Antonino Scimone, Giuseppe Chiofalo, Antonio Giordano,  and Vincenzo Adamo
8717-8725
Abstract  |  PDF  |  HTML  |  Order a Reprint

Prognostic value of microRNAs in osteosarcoma: a meta-analysis

Prognostic value of microRNAs in osteosarcoma: a meta-analysis

https://doi.org/10.18632/oncotarget.14429

Yun Hak Kim, Tae Sik Goh, Chi-Seung Lee, Sae Ock Oh, Jeung Il Kim, Seung Hyeon Jeung,  and Kyoungjune Pak
8726-8737
Abstract  |  PDF  |  HTML  |  Order a Reprint

Prognostic impact of CD73 and A2A adenosine receptor expression in non-small-cell lung cancer

Prognostic impact of CD73 and A2A adenosine receptor expression in non-small-cell lung cancer

https://doi.org/10.18632/oncotarget.14434

Yusuke Inoue, Katsuhiro Yoshimura, Nobuya Kurabe, Tomoaki Kahyo, Akikazu Kawase, Masayuki Tanahashi, Hiroshi Ogawa, Naoki Inui, Kazuhito Funai, Kazuya Shinmura, Hiroshi Niwa, Takafumi Suda,  and Haruhiko Sugimura
8738-8751
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Let-7a regulates expression of β1-adrenoceptors and forms a negative feedback circuit with the β1-adrenoceptor signaling pathway in chronic ischemic heart failure

Let-7a regulates expression of β1-adrenoceptors and forms a negative feedback circuit with the β1-adrenoceptor signaling pathway in chronic ischemic heart failure

https://doi.org/10.18632/oncotarget.14436

Yue Du, Mingyu Zhang, Wei Zhao, You Shu, Ming Gao, Yanan Zhuang, Ti Yang, Wei Mu, Tingting Li, Xin Li, Fei Sun, Zhenwei Pan,  and Yanjie Lu
8752-8764
Abstract  |  PDF  |  HTML  |  Order a Reprint

The prognostic value of clonal heterogeneity and quantitative assessment of plasma circulating clonal IG-VDJ sequences at diagnosis in patients with follicular lymphoma

The prognostic value of clonal heterogeneity and quantitative assessment of plasma circulating clonal IG-VDJ sequences at diagnosis in patients with follicular lymphoma

https://doi.org/10.18632/oncotarget.14448

Clémentine Sarkozy, Sarah Huet, Victoria E.H. Carlton, Bettina Fabiani, Alain Delmer, Fabrice Jardin, Marie-Helene Delfau-Larue, Maya Hacini, Vincent Ribrag, Stéphanie Guidez, Malek Faham,  and Gilles Salles
8765-8774
Abstract  |  PDF  |  HTML  |  Order a Reprint

A novel microRNAs expression signature for hepatocellular carcinoma diagnosis and prognosis

A novel microRNAs expression signature for hepatocellular carcinoma diagnosis and prognosis

https://doi.org/10.18632/oncotarget.14452

Mengxuan Lu, Xia Kong, Huaigao Wang, Guoliang Huang, Caiguo Ye,  and Zhiwei He
8775-8784
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Identification and functional analysis of a novel LHX1 mutation associated with congenital absence of the uterus and vagina

Identification and functional analysis of a novel LHX1 mutation associated with congenital absence of the uterus and vagina

https://doi.org/10.18632/oncotarget.14455

Wei Zhang, Xueya Zhou, Liyang Liu, Ying Zhu, Chunmei Liu, Hong Pan, Qiong Xing, Jing Wang, Xi Wang, Xuegong Zhang, Yunxia Cao,  and Binbin Wang
8785-8790
Abstract  |  PDF  |  HTML  |  Order a Reprint

Cigarette smoke induced urocystic epithelial mesenchymal transition via MAPK pathways

Cigarette smoke induced urocystic epithelial mesenchymal transition via MAPK pathways

https://doi.org/10.18632/oncotarget.14456

Dexin Yu, Hao Geng, Zhiqi Liu, Li Zhao, Zhaofeng Liang, Zhiqiang Zhang, Dongdong Xie, Yi Wang, Tao Zhang, Jie Min,  and Caiyun Zhong
8791-8800
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Clinical Research Papers

Comparison of analytic performances of Cellsearch and iFISH approach in detecting circulating tumor cells

Comparison of analytic performances of Cellsearch and iFISH approach in detecting circulating tumor cells

https://doi.org/10.18632/oncotarget.6688

Yuan Sheng, Ting Wang, Hengyu Li, Zhenzhen Zhang, Jianghao Chen, Chenyang He, Yongping Li, Yonggang Lv, Juliang Zhang, Cheng Xu, Zhen Wang, Chen Huang,  and Ling Wang
8801-8806
Abstract  |  PDF  |  HTML  |  Order a Reprint

Near infrared photoimmunotherapy with avelumab, an anti-programmed death-ligand 1 (PD-L1) antibody

Near infrared photoimmunotherapy with avelumab, an anti-programmed death-ligand 1 (PD-L1) antibody

https://doi.org/10.18632/oncotarget.12410

Tadanobu Nagaya, Yuko Nakamura, Kazuhide Sato, Toshiko Harada, Peter L. Choyke, James W. Hodge, Jeffrey Schlom,  and Hisataka Kobayashi
8807-8817
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Extralevator abdominoperineal excision for rectal cancer with biological mesh for pelvic floor reconstruction

Extralevator abdominoperineal excision for rectal cancer with biological mesh for pelvic floor reconstruction

https://doi.org/10.18632/oncotarget.12502

Wei Ge, Song-song Jiang, Wang Qi, Hao Chen, Li-ming Zheng,  and Gang Chen
8818-8824
Abstract  |  PDF  |  HTML  |  Order a Reprint

Do preoperative enlarged lymph nodes affect the oncologic outcome of laparoscopic radical gastrectomy for gastric cancer?

Do preoperative enlarged lymph nodes affect the oncologic outcome of laparoscopic radical gastrectomy for gastric cancer?

https://doi.org/10.18632/oncotarget.12549

Qi-Yue Chen, Chang-Ming Huang, Chao-Hui Zheng, Ping Li, Jian-Wei Xie, Jia-Bin Wang, Jian-Xian Lin, Jun Lu, Long-Long Cao, Mi Lin,  and Ru-Hong Tu
8825-8834
Abstract  |  PDF  |  HTML  |  Order a Reprint

The C-reactive protein/albumin ratio predicts long-term outcomes of patients with operable non-small cell lung cancer

The C-reactive protein/albumin ratio predicts long-term outcomes of patients with operable non-small cell lung cancer

https://doi.org/10.18632/oncotarget.13053

Fanrong Zhang, Lisha Ying, Jiaoyue Jin, Kaiyan Chen, Nan Zhang, Junzhou Wu, Yimin Zhang,  and Dan Su
8835-8842
Abstract  |  PDF  |  HTML  |  Order a Reprint

Reviews

Metformin therapy and the risk of colorectal adenoma in patients with type 2 diabetes: A meta-analysis

Metformin therapy and the risk of colorectal adenoma in patients with type 2 diabetes: A meta-analysis

https://doi.org/10.18632/oncotarget.13633

Yi-Chao Hou, Qiang Hu, Jiao Huang, Jing-Yuan Fang,  and Hua Xiong
8843-8853
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Improving anticancer drug development begins with cell culture: misinformation perpetrated by the misuse of cytotoxicity assays

Improving anticancer drug development begins with cell culture: misinformation perpetrated by the misuse of cytotoxicity assays

https://doi.org/10.18632/oncotarget.12673

Alan Eastman
8854-8866
Abstract  |  PDF  |  HTML  |  Order a Reprint

Chinese expert consensus on multidisciplinary diagnosis and treatment of hepatocellular carcinoma with portal vein tumor thrombus: 2016 edition

Chinese expert consensus on multidisciplinary diagnosis and treatment of hepatocellular carcinoma with portal vein tumor thrombus: 2016 edition

https://doi.org/10.18632/oncotarget.12817

Cheng Shuqun, Chen Minshan,  and Cai Jianqiang
8867-8876
Abstract  |  PDF  |  HTML  |  Order a Reprint

Next generation sequencing and its applications in HPV-associated cancers

Next generation sequencing and its applications in HPV-associated cancers

https://doi.org/10.18632/oncotarget.12830

Musaffe Tuna,  and Christopher I. Amos
8877-8889
Abstract  |  PDF  |  HTML  |  Order a Reprint

Cross-talk between microbiota and immune fitness to steer and control response to anti PD-1/PDL-1 treatment

Cross-talk between microbiota and immune fitness to steer and control response to anti PD-1/PDL-1 treatment

https://doi.org/10.18632/oncotarget.12985

Andrea Botticelli, Ilaria Zizzari, Federica Mazzuca, Paolo Antonio Ascierto, Lorenza Putignani, Luca Marchetti, Chiara Napoletano, Marianna Nuti,  and Paolo Marchetti
8890-8899
Abstract  |  PDF  |  HTML  |  Order a Reprint

γδ T cells in cancer immunotherapy

γδ T cells in cancer immunotherapy

https://doi.org/10.18632/oncotarget.13051

Chang Zou, Pan Zhao, Zhangang Xiao, Xianghua Han, Fan Fu,  and Li Fu
8900-8909
Abstract  |  PDF  |  HTML  |  Order a Reprint

Toxicity profile of approved anti-PD-1 monoclonal antibodies in solid tumors: a systematic review and meta-analysis of randomized clinical trials

Toxicity profile of approved anti-PD-1 monoclonal antibodies in solid tumors: a systematic review and meta-analysis of randomized clinical trials

https://doi.org/10.18632/oncotarget.13315

Ricardo Costa, Benedito A. Carneiro, Mark Agulnik, Alfred W. Rademaker, Sachin G. Pai, Victoria M. Villaflor, Massimo Cristofanilli, Jeffrey A. Sosman,  and Francis J. Giles
8910-8920
Abstract  |  PDF  |  HTML  |  Order a Reprint

The role of p53 in cancer drug resistance and targeted chemotherapy

The role of p53 in cancer drug resistance and targeted chemotherapy

https://doi.org/10.18632/oncotarget.13475

Karin Hientz, André Mohr, Dipita Bhakta-Guha,  and Thomas Efferth
8921-8946
Abstract  |  PDF  |  HTML  |  Order a Reprint

Impact of Mediterranean diet on metabolic syndrome, cancer and longevity

Impact of Mediterranean diet on metabolic syndrome, cancer and longevity

https://doi.org/10.18632/oncotarget.13553

Nicola Di Daniele, Annalisa Noce, Maria Francesca Vidiri, Eleonora Moriconi, Giulia Marrone, Margherita Annicchiarico-Petruzzelli, Gabriele D'Urso, Manfredi Tesauro, Valentina Rovella,  and Antonino De Lorenzo
8947-8979
Abstract  |  PDF  |  HTML  |  Order a Reprint

Histone demethylase lysine demethylase 5B in development and cancer

Histone demethylase lysine demethylase 5B in development and cancer

https://doi.org/10.18632/oncotarget.13858

Mengjiao Han, Wenxia Xu, Pu Cheng, Hongchuan Jin,  and Xian Wang
8980-8991
Abstract  |  PDF  |  HTML  |  Order a Reprint

Retraction

Retraction note: Rituximab-conjugated, doxorubicin-loaded microbubbles as a theranostic modality in B-cell lymphoma

Retraction note: Rituximab-conjugated, doxorubicin-loaded microbubbles as a theranostic modality in B-cell lymphoma

https://doi.org/10.18632/oncotarget.14897

Shoubing Zhou, Xiu Zhang,  and Cailian Wang Cailian Wang
8992-8992
Retraction  |  PDF


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