Oncotarget

Vol 7, No 48

November 29, 2016

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About The Cover

The cover for issue 48 of Oncotarget features Figure 2, 'Progression Free Survival (PFS) and Treatment-free survival (TFS) and by IGHV mutational status,' from Kay, et al.

Table of Contents

Editorial

Anesthetics and epigenetics

Anesthetics and epigenetics

https://doi.org/10.18632/oncotarget.13143

Nilkantha Sen
78220-78221
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Serotonin and sleep-promoting neurons

Serotonin and sleep-promoting neurons

https://doi.org/10.18632/oncotarget.13419

Armelle Rancillac
78222-78223
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Perineuronal nets in neurodegeneration

Perineuronal nets in neurodegeneration

https://doi.org/10.18632/oncotarget.13420

Sighild Lemarchant, Sara Wojciechowski,  and Jari Koistinaho
78224-78225
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Priority Research Papers

Hedgehog pathway dysregulation contributes to the pathogenesis of human gastrointestinal stromal tumors via GLI-mediated activation of KIT expression

Hedgehog pathway dysregulation contributes to the pathogenesis of human gastrointestinal stromal tumors via GLI-mediated activation of KIT expression

https://doi.org/10.18632/oncotarget.12909

Chih-Min Tang, Tracy E. Lee, Sabriya A. Syed, Adam M. Burgoyne, Stephanie Y. Leonard, Fei Gao, Jonathan C. Chan, Eileen Shi, Juliann Chmielecki, Deborah Morosini, Kai Wang, Jeffrey S. Ross, Michael L. Kendrick, Michael R. Bardsley, Martina De Siena, Junhao Mao, Olivier Harismendy, Tamas Ordog,  and Jason K. Sicklick
78226-78241
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CPI-17 drives oncogenic Ras signaling in human melanomas via Ezrin-Radixin-Moesin family proteins

CPI-17 drives oncogenic Ras signaling in human melanomas via Ezrin-Radixin-Moesin family proteins

https://doi.org/10.18632/oncotarget.12919

Lars Björn Riecken, Ansgar Zoch, Ulrike Wiehl, Sabine Reichert, Ingmar Scholl, Yan Cui, Mirjana Ziemer, Ulf Anderegg, Christian Hagel,  and Helen Morrison
78242-78254
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p73 expression is regulated by ribosomal protein RPL26 through mRNA translation and protein stability

p73 expression is regulated by ribosomal protein RPL26 through mRNA translation and protein stability

https://doi.org/10.18632/oncotarget.13126

Min Zhang, Jin Zhang, Wensheng Yan,  and Xinbin Chen
78255-78268
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A randomized phase II trial comparing chemoimmunotherapy with or without bevacizumab in previously untreated patients with chronic lymphocytic leukemia

A randomized phase II trial comparing chemoimmunotherapy with or without bevacizumab in previously untreated patients with chronic lymphocytic leukemia

https://doi.org/10.18632/oncotarget.13412

Neil E. Kay, Paolo Strati, Betsy R. LaPlant, Jose F. Leis, Daniel Nikcevich, Timothy G. Call, Adam M. Pettinger, Connie E. Lesnick, Curtis A. Hanson,  and Tait D. Shanafelt
78269-78280
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Research Papers: Gerotarget (Focus on Aging)

Azadiradione ameliorates polyglutamine expansion disease in Drosophila by potentiating DNA binding activity of heat shock factor 1

Azadiradione ameliorates polyglutamine expansion disease in Drosophila by potentiating DNA binding activity of heat shock factor 1

https://doi.org/10.18632/oncotarget.12930

Vinod K. Nelson, Asif Ali, Naibedya Dutta, Suvranil Ghosh, Manas Jana, Arnab Ganguli, Andrei Komarov, Soumyadip Paul, Vibha Dwivedi, Subhrangsu Chatterjee, Nihar R. Jana, Subhash C. Lakhotia, Gopal Chakrabarti, Anup K. Misra, Subhash C. Mandal,  and Mahadeb Pal
78281-78296
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Expression of functional alternative telomerase RNA component gene in mouse brain and in motor neurons cells protects from oxidative stress

Expression of functional alternative telomerase RNA component gene in mouse brain and in motor neurons cells protects from oxidative stress

https://doi.org/10.18632/oncotarget.13049

Erez Eitan, Admoni Tamar, Grin Yossi, Refael Peleg, Alex Braiman,  and Esther Priel
78297-78309
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Presence of lacunar infarctions is associated with the spatial navigation impairment in patients with mild cognitive impairment: a DTI study

Presence of lacunar infarctions is associated with the spatial navigation impairment in patients with mild cognitive impairment: a DTI study

https://doi.org/10.18632/oncotarget.13409

Yan-Feng Wu, Wen-Bo Wu, Qing-Ping Liu, Wen-Wen He, Hong Ding, Zuzana Nedelska, Jakub Hort, Bing Zhang,  and Yun Xu
78310-78319
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Research Papers: Pathology

Sulfuretin promotes osteoblastic differentiation in primary cultured osteoblasts and in vivo bone healing

Sulfuretin promotes osteoblastic differentiation in primary cultured osteoblasts and in vivo bone healing

https://doi.org/10.18632/oncotarget.12460

Q-Schick Auh, Kyung-Ran Park, Hyung-Mun Yun, Hyun-Chang Lim, Ga-Hyun Kim, Dong-Sung Lee, Youn-Chul Kim, Hyuncheol Oh,  and Eun-Cheol Kim
78320-78330
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Targeting EZH1 and EZH2 contributes to the suppression of fibrosis-associated genes by miR-214-3p in cardiac myofibroblasts

Targeting EZH1 and EZH2 contributes to the suppression of fibrosis-associated genes by miR-214-3p in cardiac myofibroblasts

https://doi.org/10.18632/oncotarget.13048

Wen-Si Zhu, Chun-Mei Tang, Zhen Xiao, Jie-Ning Zhu, Qiu-Xiong Lin, Yong-Heng Fu, Zhi-Qin Hu, Zhuo Zhang, Min Yang, Xi-Long Zheng, Shu-Lin Wu,  and Zhi-Xin Shan
78331-78342
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Dysregulation of macrophage polarization is associated with the metastatic process in osteosarcoma

Dysregulation of macrophage polarization is associated with the metastatic process in osteosarcoma

https://doi.org/10.18632/oncotarget.13055

Clotilde Dumars, Jean-Michel Ngyuen, Aurélie Gaultier, Rachel Lanel, Nadège Corradini, François Gouin, Dominique Heymann,  and Marie-Françoise Heymann
78343-78354
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High frequency of clonal IG and T-cell receptor gene rearrangements in histiocytic and dendritic cell neoplasms

High frequency of clonal IG and T-cell receptor gene rearrangements in histiocytic and dendritic cell neoplasms

https://doi.org/10.18632/oncotarget.13058

Wenting Huang, Tian Qiu, Linshu Zeng, Bo Zheng, Jianming Ying,  and Xiaoli Feng
78355-78362
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Novel mutations c.28G>T (p.Ala10Ser) and c.189G>T (p.Glu63Asp) in WDR62 associated with early onset acanthosis and hyperkeratosis in a patient with autosomal recessive microcephaly type 2

Novel mutations c.28G>T (p.Ala10Ser) and c.189G>T (p.Glu63Asp) in WDR62 associated with early onset acanthosis and hyperkeratosis in a patient with autosomal recessive microcephaly type 2

https://doi.org/10.18632/oncotarget.13279

Santasree Banerjee, Huishuang Chen, Hui Huang, Jing Wu, Zhiyun Yang, Weiping Deng, Dongna Chen, Jianlian Deng, Yan Su, Yang Li, Chao Wu, Ye Wang, Hao Zeng, Yiming Wang,  and Xunhua Li
78363-78371
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Ischemic preconditioning attenuates ischemia/reperfusion injury in rat steatotic liver: role of heme oxygenase-1-mediated autophagy

Ischemic preconditioning attenuates ischemia/reperfusion injury in rat steatotic liver: role of heme oxygenase-1-mediated autophagy

https://doi.org/10.18632/oncotarget.13281

Anding Liu, Enshuang Guo, Jiankun Yang, Renlong Li, Yan Yang, Shenpei Liu, Jifa Hu, Xiaojing Jiang, Olaf Dirsch, Uta Dahmen, Jian Sun,  and Mingwen Ouyang
78372-78386
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New conception for the development of hypertension in preeclampsia

New conception for the development of hypertension in preeclampsia

https://doi.org/10.18632/oncotarget.13410

Qinqin Gao, Jiaqi Tang, Na Li, Xiuwen Zhou, Xiaolin Zhu, Weisheng Li, Bailin Liu, Xueqin Feng, Jianying Tao, Bing Han, Hong Zhang, Miao Sun,  and Zhice Xu
78387-78395
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Unique metabolic features of pancreatic cancer stroma: relevance to the tumor compartment, prognosis, and invasive potential

Unique metabolic features of pancreatic cancer stroma: relevance to the tumor compartment, prognosis, and invasive potential

https://doi.org/10.18632/oncotarget.11893

Erik S. Knudsen, Uthra Balaji, Elizaveta Freinkman, Peter McCue,  and Agnieszka K. Witkiewicz
78396-78411
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Research Papers: Immunology

Gene therapy with plasmids encoding IFN-β or IFN-α14 confers long-term resistance to HIV-1 in humanized mice

Gene therapy with plasmids encoding IFN-β or IFN-α14 confers long-term resistance to HIV-1 in humanized mice

https://doi.org/10.18632/oncotarget.12512

Sojan Abraham, Jang-Gi Choi, Nora M. Ortega, Junli Zhang, Premlata Shankar,  and N. Manjunath Swamy
78412-78420
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Research Papers

A novel microfluidic model can mimic organ-specific metastasis of circulating tumor cells

A novel microfluidic model can mimic organ-specific metastasis of circulating tumor cells

https://doi.org/10.18632/oncotarget.9382

Jing Kong, Yong Luo, Dong Jin, Fan An, Wenyuan Zhang, Lilu Liu, Jiao Li, Shimeng Fang, Xiaojie Li, Xuesong Yang, Bingcheng Lin,  and Tingjiao Liu
78421-78432
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MiR-99b-5p expression and response to tyrosine kinase inhibitor treatment in clear cell renal cell carcinoma patients

MiR-99b-5p expression and response to tyrosine kinase inhibitor treatment in clear cell renal cell carcinoma patients

https://doi.org/10.18632/oncotarget.12618

Magdalena Lukamowicz-Rajska, Christiane Mittmann, Michael Prummer, Qing Zhong, Jens Bedke, Jörg Hennenlotter, Arnulf Stenzl, Axel Mischo, Svenja Bihr, Manuela Schmidinger, Ursula Vogl, Iris Blume, Christoph Karlo, Peter Schraml,  and Holger Moch
78433-78447
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Clinical outcomes of advanced-stage glassy cell carcinoma of the uterine cervix: a need for reappraisal

Clinical outcomes of advanced-stage glassy cell carcinoma of the uterine cervix: a need for reappraisal

https://doi.org/10.18632/oncotarget.12905

Nara Yoon, Ji-Ye Kim,  and Hyun-Soo Kim
78448-78454
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Endoplasmic reticulum stress-induced neuronal inflammatory response and apoptosis likely plays a key role in the development of diabetic encephalopathy

Endoplasmic reticulum stress-induced neuronal inflammatory response and apoptosis likely plays a key role in the development of diabetic encephalopathy

https://doi.org/10.18632/oncotarget.12925

Zhouguang Wang, Yan Huang, Yi Cheng, Yi Tan, Fenzan Wu, Jiamin Wu, Hongxue Shi, Hongyu Zhang, Xichong Yu, Hongchang Gao, Li Lin, Jun Cai, Jinsan Zhang, Xiaokun Li, Lu Cai,  and Jian Xiao
78455-78472
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The role of Tks adaptor proteins in invadopodia formation, growth and metastasis of melanoma

The role of Tks adaptor proteins in invadopodia formation, growth and metastasis of melanoma

https://doi.org/10.18632/oncotarget.12954

Shinji Iizuka, Christopher Abdullah, Matthew D. Buschman, Begoña Diaz,  and Sara A. Courtneidge
78473-78486
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A scoring system basing pathological parameters to predict regional lymph node metastasis after preoperative chemoradiotherapy for locally advanced rectal cancer: implication for local excision

A scoring system basing pathological parameters to predict regional lymph node metastasis after preoperative chemoradiotherapy for locally advanced rectal cancer: implication for local excision

https://doi.org/10.18632/oncotarget.10965

Xiao-Jie Wang, Pan Chi, Hui-Ming Lin, Xing-Rong Lu, Ying Huang, Zong-Bin Xu, Sheng-Hui Huang, Yan-Wu Sun, Dao-Xiong Ye,  and Qian Yu
78487-78498
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A rational approach for cancer stem-like cell isolation and characterization using CD44 and prominin-1(CD133) as selection markers

A rational approach for cancer stem-like cell isolation and characterization using CD44 and prominin-1(CD133) as selection markers

https://doi.org/10.18632/oncotarget.12100

Yi-Jen Lee, Chang-Cheng Wu, Jhy-Wei Li, Chien-Chih Ou, Shih-Chung Hsu, Hsiu-Hsueh Tseng, Ming-Ching Kao,  and Jah-Yao Liu
78499-78515
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Inhibition of autophagy inhibits the conversion of cardiac fibroblasts to cardiac myofibroblasts

Inhibition of autophagy inhibits the conversion of cardiac fibroblasts to cardiac myofibroblasts

https://doi.org/10.18632/oncotarget.12392

Shivika S. Gupta, Matthew R. Zeglinski, Sunil G. Rattan, Natalie M. Landry, Saeid Ghavami, Jeffrey T. Wigle, Thomas Klonisch, Andrew J. Halayko,  and Ian M.C. Dixon
78516-78531
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Copy number gain of VCX, X-linked multi-copy gene, leads to cell proliferation and apoptosis during spermatogenesis

Copy number gain of VCX, X-linked multi-copy gene, leads to cell proliferation and apoptosis during spermatogenesis

https://doi.org/10.18632/oncotarget.12397

Juan Ji, Yufeng Qin, Rong Wang, Zhenyao Huang, Yan Zhang, Ran Zhou, Ling Song, Xiufeng Ling, Zhibin Hu, Dengshun Miao, Hongbing Shen, Yankai Xia, Xinru Wang,  and Chuncheng Lu
78532-78540
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Analysis of angiogenesis related factors in glioblastoma, peritumoral tissue and their derived cancer stem cells

Analysis of angiogenesis related factors in glioblastoma, peritumoral tissue and their derived cancer stem cells

https://doi.org/10.18632/oncotarget.12398

Alessio D’Alessio, Gabriella Proietti, Gina Lama, Filippo Biamonte, Libero Lauriola, Umberto Moscato, Angelo Vescovi, Annunziato Mangiola, Cristiana Angelucci,  and Gigliola Sica
78541-78556
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Simultaneous high expression of PLD1 and Sp1 predicts a poor prognosis for pancreatic ductal adenocarcinoma patients

Simultaneous high expression of PLD1 and Sp1 predicts a poor prognosis for pancreatic ductal adenocarcinoma patients

https://doi.org/10.18632/oncotarget.12447

Jiong Hu, Hai Hu, Jun-jie Hang, Hai-yan Yang, Zhi-yong Wang, Lei Wang, Dong-hui Chen,  and Li-wei Wang
78557-78565
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Fatty acid synthase is a primary target of MiR-15a and MiR-16-1 in breast cancer

Fatty acid synthase is a primary target of MiR-15a and MiR-16-1 in breast cancer

https://doi.org/10.18632/oncotarget.12479

Jingxuan Wang, Xiao Zhang, Jinming Shi, Paul Cao, Meimei Wan, Qiang Zhang, Yunxuan Wang, Steven J. Kridel, Wennuan Liu, Jianfeng Xu, Qingyuan Zhang,  and Guangchao Sui
78566-78576
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A functional signal profiling test for identifying a subset of HER2-negative breast cancers with abnormally amplified HER2 signaling activity

A functional signal profiling test for identifying a subset of HER2-negative breast cancers with abnormally amplified HER2 signaling activity

https://doi.org/10.18632/oncotarget.12480

Yao Huang, David J Burns, Benjamin E Rich, Ian A MacNeil, Abhijit Dandapat, Sajjad M. Soltani, Samantha Myhre, Brian F Sullivan, Leo T Furcht, Carol A Lange, Sara A Hurvitz,  and Lance G Laing
78577-78590
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In Vivo magnetic resonance imaging of xenografted tumors using FTH1 reporter gene expression controlled by a tet-on switch

In Vivo magnetic resonance imaging of xenografted tumors using FTH1 reporter gene expression controlled by a tet-on switch

https://doi.org/10.18632/oncotarget.12519

Xiaoya He, Jinhua Cai, Hao Li, Bo Liu, Yong Qin, Yi Zhong, Longlun Wang,  and Yifan Liao
78591-78604
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CCR10/CCL27 crosstalk contributes to failure of proteasome-inhibitors in multiple myeloma

CCR10/CCL27 crosstalk contributes to failure of proteasome-inhibitors in multiple myeloma

https://doi.org/10.18632/oncotarget.12522

Shanmugapriya Thangavadivel, Claudia Zelle-Rieser, Angelika Olivier, Benno Postert, Gerold Untergasser, Johann Kern, Andrea Brunner, Eberhard Gunsilius, Rainer Biedermann, Roman Hajek, Ludek Pour, Wolfgang Willenbacher, Richard Greil,  and Karin Jöhrer
78605-78618
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Inhibition of calcium-activated chloride channel ANO1 suppresses proliferation and induces apoptosis of epithelium originated cancer cells

Inhibition of calcium-activated chloride channel ANO1 suppresses proliferation and induces apoptosis of epithelium originated cancer cells

https://doi.org/10.18632/oncotarget.12524

Lizhao Guan, Yan Song, Jian Gao, Jianjun Gao,  and KeWei Wang
78619-78630
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Quantitative assessment of polymorphisms in H19 lncRNA and cancer risk: a meta-analysis of 13,392 cases and 18,893 controls

Quantitative assessment of polymorphisms in H19 lncRNA and cancer risk: a meta-analysis of 13,392 cases and 18,893 controls

https://doi.org/10.18632/oncotarget.12530

Minjie Chu, Weiyan Yuan, Shuangshuang Wu, Zhiquan Wang, Liping Mao, Tian Tian, Yihua Lu, Bowen Zhu, Yue Yang, Bin Wang, Haiquan Gao, Liying Jiang,  and Xun Zhuang
78631-78639
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The microRNA miR-33a suppresses IL-6-induced tumor progression by binding Twist in gallbladder cancer

The microRNA miR-33a suppresses IL-6-induced tumor progression by binding Twist in gallbladder cancer

https://doi.org/10.18632/oncotarget.12693

Mingdi Zhang, Wei Gong, Bin Zuo, Bingfeng Chu, Zhaohui Tang, Yong Zhang, Yong Yang, Di Zhou, Mingzhe Weng, Yiyu Qin, Mingzhe Ma, Alex Jiang, Fei Ma,  and Zhiwei Quan
78640-78652
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Mertk on tumor macrophages is a therapeutic target to prevent tumor recurrence following radiation therapy

Mertk on tumor macrophages is a therapeutic target to prevent tumor recurrence following radiation therapy

https://doi.org/10.18632/oncotarget.11823

Marka R. Crittenden, Jason Baird, David Friedman, Talicia Savage, Lauren Uhde, Alejandro Alice, Benjamin Cottam, Kristina Young, Pippa Newell, Cynthia Nguyen, Shelly Bambina, Gwen Kramer, Emmanuel Akporiaye, Anna Malecka, Andrew Jackson,  and Michael J. Gough
78653-78666
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miR-125b regulates differentiation and metabolic reprogramming of T cell acute lymphoblastic leukemia by directly targeting A20

miR-125b regulates differentiation and metabolic reprogramming of T cell acute lymphoblastic leukemia by directly targeting A20

https://doi.org/10.18632/oncotarget.12018

Zixing Liu, Kelly R. Smith, Hung T. Khong, Jingshan Huang, Eun-Young Erin Ahn, Ming Zhou,  and Ming Tan
78667-78679
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Down-regulated resistin level in consequence of decreased neutrophil counts in untreated Grave's disease

Down-regulated resistin level in consequence of decreased neutrophil counts in untreated Grave's disease

https://doi.org/10.18632/oncotarget.12019

Ying Peng, Yicheng Qi, Fengjiao Huang, Xinxin Chen, Yulin Zhou, Lei Ye, Weiqing Wang, Guang Ning,  and Shu Wang
78680-78687
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Serum carboxypeptidaseA4 levels predict liver metastasis in colorectal carcinoma

Serum carboxypeptidaseA4 levels predict liver metastasis in colorectal carcinoma

https://doi.org/10.18632/oncotarget.12798

Lichao Sun, Chunguang Guo, Joseph Burnett, Zhihua Yang, Yuliang Ran,  and Duxin Sun
78688-78697
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CD133+CD24lo defines a 5-Fluorouracil-resistant colon cancer stem cell-like phenotype

CD133+CD24lo defines a 5-Fluorouracil-resistant colon cancer stem cell-like phenotype

https://doi.org/10.18632/oncotarget.12168

Amy V. Paschall, Dafeng Yang, Chunwan Lu, Priscilla S. Redd, Jeong-Hyeon Choi, Christopher M. Heaton, Jeffrey R. Lee, Asha Nayak-Kapoor,  and Kebin Liu
78698-78712
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SIN3A and SIN3B differentially regulate breast cancer metastasis

SIN3A and SIN3B differentially regulate breast cancer metastasis

https://doi.org/10.18632/oncotarget.12805

Monica J. Lewis, Jianzhong Liu, Emily Falk Libby, Minnkyong Lee, Nigel P.S. Crawford,  and Douglas R. Hurst
78713-78725
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MFHAS1 promotes colorectal cancer progress by regulating polarization of tumor-associated macrophages via STAT6 signaling pathway

MFHAS1 promotes colorectal cancer progress by regulating polarization of tumor-associated macrophages via STAT6 signaling pathway

https://doi.org/10.18632/oncotarget.12807

Wankun Chen, Yajun Xu, Jing Zhong, Huihui Wang, Meilin Weng, Qian Cheng, Qichao Wu, Zhirong Sun, Hui Jiang, Minmin Zhu, Yu Ren, Pingbo Xu, Jiawei Chen,  and Changhong Miao
78726-78735
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Optimization of radiotherapy for neck carcinoma metastasis from unknown primary sites: a meta-analysis

Optimization of radiotherapy for neck carcinoma metastasis from unknown primary sites: a meta-analysis

https://doi.org/10.18632/oncotarget.12852

Xiaomei Liu, Dianhe Li, Na Li,  and Xiaoxia Zhu
78736-78746
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

PICT-1 triggers a pro-death autophagy through inhibiting rRNA transcription and AKT/mTOR/p70S6K signaling pathway

PICT-1 triggers a pro-death autophagy through inhibiting rRNA transcription and AKT/mTOR/p70S6K signaling pathway

https://doi.org/10.18632/oncotarget.12288

Hongbo Chen, Yanhong Duo, Bo Hu, Zhiwei Wang, Fang Zhang, Hsiangi Tsai, Jianping Zhang, Lanzhen Zhou, Lijun Wang, Xinyu Wang,  and Laiqiang Huang
78747-78763
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Fasudil, an inhibitor of Rho-associated coiled-coil kinase, improves cognitive impairments induced by smoke exposure

Fasudil, an inhibitor of Rho-associated coiled-coil kinase, improves cognitive impairments induced by smoke exposure

https://doi.org/10.18632/oncotarget.12853

Deng Xueyang, Ma Zhanqiang, Ma Chunhua,  and Hao Kun
78764-78772
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A 5-day cytoreductive chemotherapy followed by haplo-identical hsct (FA5-BUCY) as a tumor-ablative regimen improved the survival of patients with advanced hematological malignancies

A 5-day cytoreductive chemotherapy followed by haplo-identical hsct (FA5-BUCY) as a tumor-ablative regimen improved the survival of patients with advanced hematological malignancies

https://doi.org/10.18632/oncotarget.12383

Ting Yang, Qiaoxian Lin, Jinhua Ren, Ping Chen, Xiaohong Yuan, Xiaofeng Luo, Tingbo Liu, Jing Zheng, Zhihong Zheng, Xiaoyun Zheng, Xinji Chen, Langhui Zhang, Hao Zheng, Zaisheng Chen, Xueling Hua, Shaohua Le, Jian Li, Zhizhe Chen,  and Jianda Hu
78773-78786
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Metformin treatment reduces temozolomide resistance of glioblastoma cells

Metformin treatment reduces temozolomide resistance of glioblastoma cells

https://doi.org/10.18632/oncotarget.12859

Seung Ho Yang, Shenglan Li, Guangrong Lu, Haipeng Xue, Dong H. Kim, Jay-Jiguang Zhu,  and Ying Liu
78787-78803
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Nuclear transcription factor Nrf2 suppresses prostate cancer cells growth and migration through upregulating ferroportin

Nuclear transcription factor Nrf2 suppresses prostate cancer cells growth and migration through upregulating ferroportin

https://doi.org/10.18632/oncotarget.12860

Dong Xue, Cuixing Zhou, Yunbo Shi, Hao Lu, Renfang Xu,  and Xiaozhou He
78804-78812
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miR128-1 inhibits the growth of glioblastoma multiforme and glioma stem-like cells via targeting BMI1 and E2F3

miR128-1 inhibits the growth of glioblastoma multiforme and glioma stem-like cells via targeting BMI1 and E2F3

https://doi.org/10.18632/oncotarget.12385

Zheng-nan Shan, Rui Tian, Min Zhang, Zhao-hua Gui, Jing Wu, Min Ding, Xin-Fu Zhou,  and Jie He
78813-78826
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KRAS mutations in blood circulating cell-free DNA: a pancreatic cancer case-control

KRAS mutations in blood circulating cell-free DNA: a pancreatic cancer case-control

https://doi.org/10.18632/oncotarget.12386

Florence Le Calvez-Kelm, Matthieu Foll, Magdalena B. Wozniak, Tiffany M. Delhomme, Geoffroy Durand, Priscilia Chopard, Maroulio Pertesi, Eleonora Fabianova, Zora Adamcakova, Ivana Holcatova, Lenka Foretova, Vladimir Janout, Maxime P. Vallee, Sabina Rinaldi, Paul Brennan, James D. McKay, Graham B. Byrnes,  and Ghislaine Scelo
78827-78840
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Comparative analysis of protein interactome networks prioritizes candidate genes with cancer signatures

Comparative analysis of protein interactome networks prioritizes candidate genes with cancer signatures

https://doi.org/10.18632/oncotarget.12879

Yongsheng Li, Nidhi Sahni,  and Song Yi
78841-78849
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Identification of a serum circulating lncRNA panel for the diagnosis and recurrence prediction of bladder cancer

Identification of a serum circulating lncRNA panel for the diagnosis and recurrence prediction of bladder cancer

https://doi.org/10.18632/oncotarget.12880

Weili Duan, Lutao Du, Xiumei Jiang, Rui Wang, Suzhen Yan, Yujiao Xie, Keqiang Yan, Qingliang Wang, Lili Wang, Xin Zhang, Hongwei Pan, Yongmei Yang,  and Chuanxin Wang
78850-78858
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Metastasis-suppressing NID2, an epigenetically-silenced gene, in the pathogenesis of nasopharyngeal carcinoma and esophageal squamous cell carcinoma

Metastasis-suppressing NID2, an epigenetically-silenced gene, in the pathogenesis of nasopharyngeal carcinoma and esophageal squamous cell carcinoma

https://doi.org/10.18632/oncotarget.12889

Annie Wai Yeeng Chai, Arthur Kwok Leung Cheung, Wei Dai, Josephine Mun Yee Ko, Joseph Chok Yan Ip, Kwok Wah Chan, Dora Lai-Wan Kwong, Wai Tong Ng, Anne Wing Mui Lee, Roger Kai Cheong Ngan, Chun Chung Yau, Stewart Yuk Tung, Victor Ho Fun Lee, Alfred King-Yin Lam, Suja Pillai, Simon Law,  and Maria Li Lung
78859-78871
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Premalignant alteration assessment in liver-like tissue derived from embryonic stem cells by aristolochic acid I exposure

Premalignant alteration assessment in liver-like tissue derived from embryonic stem cells by aristolochic acid I exposure

https://doi.org/10.18632/oncotarget.12424

Ke Jin, Dan-yan Zhu, Lu Li, Zheng-rong Mao, Bo-wen Wu, Yi-fan Wang, Zong-fu Pan, Lan-juan Li, Chun-sheng Xiang, Kun-kai Su,  and Yi-jia Lou
78872-78882
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Selinexor, a Selective Inhibitor of Nuclear Export (SINE) compound, acts through NF-κB deactivation and combines with proteasome inhibitors to synergistically induce tumor cell death

Selinexor, a Selective Inhibitor of Nuclear Export (SINE) compound, acts through NF-κB deactivation and combines with proteasome inhibitors to synergistically induce tumor cell death

https://doi.org/10.18632/oncotarget.12428

Trinayan Kashyap, Christian Argueta, Amro Aboukameel, Thaddeus John Unger, Boris Klebanov, Ramzi M. Mohammad, Irfana Muqbil, Asfar S. Azmi, Claire Drolen, William Senapedis, Margaret Lee, Michael Kauffman, Sharon Shacham,  and Yosef Landesman
78883-78895
Abstract  |  PDF  |  HTML  |  Order a Reprint

XPO1 inhibitor combination therapy with bortezomib or carfilzomib induces nuclear localization of IκBα and overcomes acquired proteasome inhibitor resistance in human multiple myeloma

XPO1 inhibitor combination therapy with bortezomib or carfilzomib induces nuclear localization of IκBα and overcomes acquired proteasome inhibitor resistance in human multiple myeloma

https://doi.org/10.18632/oncotarget.12969

Joel G. Turner, Trinayan Kashyap, Jana L. Dawson, Juan Gomez, Alexis A. Bauer, Steven Grant, Yun Dai, Kenneth H. Shain, Mark Meads, Yosef Landesman,  and Daniel M. Sullivan
78896-78909
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c-Myc is regulated by HIF-2α in chronic hypoxia and influences sensitivity to 5-FU in colon cancer

c-Myc is regulated by HIF-2α in chronic hypoxia and influences sensitivity to 5-FU in colon cancer

https://doi.org/10.18632/oncotarget.12911

Liangjing Wang, Meng Xue,  and Daniel C. Chung
78910-78917
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DDR2 overexpression in urothelial carcinoma indicates an unfavorable prognosis: a large cohort study

DDR2 overexpression in urothelial carcinoma indicates an unfavorable prognosis: a large cohort study

https://doi.org/10.18632/oncotarget.12912

Meng-Chen Tsai, Wei-Ming Li, Chun-Nung Huang, Hung-Lung Ke, Ching-Chia Li, Hsin-Chih Yeh, Ti-Chun Chan, Peir-In Liang, Bi-Wen Yeh, Wen-Jeng Wu, Sher-Wei Lim,  and Chien-Feng Li
78918-78931
Abstract  |  PDF  |  HTML  |  Order a Reprint

Transcriptional upregulation of c-MET is associated with invasion and tumor budding in colorectal cancer

Transcriptional upregulation of c-MET is associated with invasion and tumor budding in colorectal cancer

https://doi.org/10.18632/oncotarget.12933

Conor A. Bradley, Philip D. Dunne, Victoria Bingham, Stephen McQuaid, Hajrah Khawaja, Stephanie Craig, Jackie James, Wendy L. Moore, Darragh G. McArt, Mark Lawler, Sonali Dasgupta, Patrick G. Johnston,  and Sandra Van Schaeybroeck
78932-78945
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Attenuation of cancer-initiating cells stemness properties by abrogating S100A4 calcium binding ability in head and neck cancers

Attenuation of cancer-initiating cells stemness properties by abrogating S100A4 calcium binding ability in head and neck cancers

https://doi.org/10.18632/oncotarget.12935

Li-Hao Cheng, Kai-Feng Hung, Tung-Fu Huang, Hsin-Pei Hsieh, Shu-Ying Wang, Chih-Yang Huang,  and Jeng-Fan Lo
78946-78957
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Mitotic arrest-induced phosphorylation of Mcl-1 revisited using two-dimensional gel electrophoresis and phosphoproteomics: nine phosphorylation sites identified

Mitotic arrest-induced phosphorylation of Mcl-1 revisited using two-dimensional gel electrophoresis and phosphoproteomics: nine phosphorylation sites identified

https://doi.org/10.18632/oncotarget.12586

Rong Chu, Sarah E. Alford, Katherine Hart, Anisha Kothari, Samuel G. Mackintosh, Matthew R. Kovak,  and Timothy C. Chambers
78958-78970
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The nuclear corepressor 1 and the thyroid hormone receptor β suppress breast tumor lymphangiogenesis

The nuclear corepressor 1 and the thyroid hormone receptor β suppress breast tumor lymphangiogenesis

https://doi.org/10.18632/oncotarget.12978

Olaia Martínez-Iglesias, David Olmeda, Elvira Alonso-Merino, Sara Gómez-Rey, Ana M. González-López, Enrique Luengo, María S. Soengas, José Palacios, Javier Regadera,  and Ana Aranda
78971-78984
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The prevalence of EGFR mutation in patients with non-small cell lung cancer: a systematic review and meta-analysis

The prevalence of EGFR mutation in patients with non-small cell lung cancer: a systematic review and meta-analysis

https://doi.org/10.18632/oncotarget.12587

Yue-Lun Zhang, Jin-Qiu Yuan, Kai-Feng Wang, Xiao-Hong Fu, Xiao-Ran Han, Diane Threapleton, Zu-Yao Yang, Chen Mao,  and Jin-Ling Tang
78985-78993
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Overexpression of stathmin promotes metastasis and growth of malignant solid tumors: a systemic review and meta-analysis

Overexpression of stathmin promotes metastasis and growth of malignant solid tumors: a systemic review and meta-analysis

https://doi.org/10.18632/oncotarget.12982

Rong Biaoxue, Liu Hua, Gao Wenlong,  and Yang Shuanying
78994-79007
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Dietary iron intake and breast cancer risk: modulation by an antioxidant supplementation

Dietary iron intake and breast cancer risk: modulation by an antioxidant supplementation

https://doi.org/10.18632/oncotarget.12592

Abou Diallo, Mélanie Deschasaux, Valentin Partula, Paule Latino-Martel, Bernard Srour, Serge Hercberg, Pilar Galan, Philippine Fassier, Françoise Guéraud, Fabrice H. Pierre,  and Mathilde Touvier
79008-79016
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

ING4 suppresses tumor angiogenesis and functions as a prognostic marker in human colorectal cancer

ING4 suppresses tumor angiogenesis and functions as a prognostic marker in human colorectal cancer

https://doi.org/10.18632/oncotarget.12984

Yansu Chen, Yefei Huang, Pingfu Hou, Zhe Zhang, Yafei Zhang, Weimin Wang, Guixiang Sun, Lichun Xu, Jianwei Zhou, Jin Bai,  and Junnian Zheng
79017-79031
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Antagonizing miR-218-5p attenuates Wnt signaling and reduces metastatic bone disease of triple negative breast cancer cells

Antagonizing miR-218-5p attenuates Wnt signaling and reduces metastatic bone disease of triple negative breast cancer cells

https://doi.org/10.18632/oncotarget.12593

Hanna Taipaleenmäki, Nicholas H. Farina, Andre J. van Wijnen, Janet L. Stein, Eric Hesse, Gary S. Stein,  and Jane B. Lian
79032-79046
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Autophagy negatively regulates tumor cell proliferation through phosphorylation dependent degradation of the Notch1 intracellular domain

Autophagy negatively regulates tumor cell proliferation through phosphorylation dependent degradation of the Notch1 intracellular domain

https://doi.org/10.18632/oncotarget.12986

Ji-Seon Ahn, Eun-Jung Ann, Mi-Yeon Kim, Ji-Hye Yoon, Hye-Jin Lee, Eun-Hye Jo, Keesook Lee, Ji Shin Lee,  and Hee-Sae Park
79047-79063
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Synergistic targeting of Sp1, a critical transcription factor for myeloma cell growth and survival, by panobinostat and proteasome inhibitors

Synergistic targeting of Sp1, a critical transcription factor for myeloma cell growth and survival, by panobinostat and proteasome inhibitors

https://doi.org/10.18632/oncotarget.12594

Ariunzaya Bat-Erdene, Hirokazu Miki, Asuko Oda, Shingen Nakamura, Jumpei Teramachi, Ryota Amachi, Hirofumi Tenshin, Masahiro Hiasa, Masami Iwasa, Takeshi Harada, Shiro Fujii, Kimiko Sogabe, Kumiko Kagawa, Sumiko Yoshida, Itsuro Endo, Kenichi Aihara,  and Masahiro Abe
79064-79075
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Antitumor activity of curcumin is involved in down-regulation of YAP/TAZ expression in pancreatic cancer cells

Antitumor activity of curcumin is involved in down-regulation of YAP/TAZ expression in pancreatic cancer cells

https://doi.org/10.18632/oncotarget.12596

Xiuxia Zhou, Jingna Su, Shaoyan Feng, Lixia Wang, Xuyuan Yin, Jingzhe Yan,  and Zhiwei Wang
79076-79088
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Radiosensitizing effect of lapatinib in human epidermal growth factor receptor 2-positive breast cancer cells

Radiosensitizing effect of lapatinib in human epidermal growth factor receptor 2-positive breast cancer cells

https://doi.org/10.18632/oncotarget.12597

Tosol Yu, Bong Jun Cho, Eun Jung Choi, Ji Min Park, Dan Hyo Kim,  and In Ah Kim
79089-79100
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

GBM heterogeneity as a function of variable epidermal growth factor receptor variant III activity

GBM heterogeneity as a function of variable epidermal growth factor receptor variant III activity

https://doi.org/10.18632/oncotarget.12600

Olle R. Lindberg, Andrew McKinney, Jane R. Engler, Gayane Koshkakaryan, Henry Gong, Aaron E. Robinson, Andrew J. Ewald, Emmanuelle Huillard, C. David James, Annette M. Molinaro, Joseph T. Shieh,  and Joanna J. Phillips
79101-79116
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Defective ciliogenesis in thyroid hürthle cell tumors is associated with increased autophagy

Defective ciliogenesis in thyroid hürthle cell tumors is associated with increased autophagy

https://doi.org/10.18632/oncotarget.12997

Junguee Lee, Shinae Yi, Yea Eun Kang, Joon Young Chang, Jung Tae Kim, Hae Joung Sul, Jong Ok Kim, Jin Man Kim, Joon Kim, Anna Maria Porcelli, Koon Soon Kim,  and Minho Shong
79117-79130
Abstract  |  PDF  |  HTML  |  Order a Reprint

Therapeutic effects of umbilical cord blood plasma in a rat model of acute ischemic stroke

Therapeutic effects of umbilical cord blood plasma in a rat model of acute ischemic stroke

https://doi.org/10.18632/oncotarget.12998

Jongman Yoo, Han-Soo Kim, Jin-Ju Seo, Jang-Hyoun Eom, Seong-Mi Choi, Sanghyun Park, Dong-Wook Kim,  and Dong-Youn Hwang
79131-79140
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Ubenimex attenuates acquired sorafenib resistance in renal cell carcinoma by inhibiting Akt signaling in a lipophagy associated mechanism

Ubenimex attenuates acquired sorafenib resistance in renal cell carcinoma by inhibiting Akt signaling in a lipophagy associated mechanism

https://doi.org/10.18632/oncotarget.13003

Shuai Liu, Mingwei Gao, Xiaoqing Wang, Sentai Ding, Jiaju Lv, Dexuan Gao, Zhiyang Wang,  and Zhihong Niu
79141-79153
Abstract  |  PDF  |  HTML  |  Order a Reprint

Proteomic analysis reveals diverse proline hydroxylation-mediated oxygen-sensing cellular pathways in cancer cells

Proteomic analysis reveals diverse proline hydroxylation-mediated oxygen-sensing cellular pathways in cancer cells

https://doi.org/10.18632/oncotarget.12632

Tong Zhou, Luke Erber, Bing Liu, Yankun Gao, Hai-Bin Ruan,  and Yue Chen
79154-79169
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Anti-metastatic effect of the TM4SF5-specific peptide vaccine and humanized monoclonal antibody on colon cancer in a mouse lung metastasis model

Anti-metastatic effect of the TM4SF5-specific peptide vaccine and humanized monoclonal antibody on colon cancer in a mouse lung metastasis model

https://doi.org/10.18632/oncotarget.13005

Guang Wu, Dongbum Kim, Byoung Kwon Park, Sangkyu Park, Ji-Hee Ha, Te Ha Kim, Avishekh Gautam, Jung Nam Kim, Su In Lee, Han-Bum Park, Yong-Sung Kim, Hyung-Joo Kwon,  and Younghee Lee
79170-79186
Abstract  |  PDF  |  HTML  |  Order a Reprint

The anti-tumor role of NK cells in vivo pre-activated and re-stimulated by interleukins in acute lymphoblastic leukemia

The anti-tumor role of NK cells in vivo pre-activated and re-stimulated by interleukins in acute lymphoblastic leukemia

https://doi.org/10.18632/oncotarget.13007

Fengyan Jin, Hai Lin, Sujun Gao, Zheng Hu, Song Zuo, Liguang Sun, Chunhui Jin, Wei Li,  and Yanping Yang
79187-79202
Abstract  |  PDF  |  HTML  |  Order a Reprint

Spatio-temporal regulation of EGFR signaling by the Eps15 homology domain-containing protein 3 (EHD3)

Spatio-temporal regulation of EGFR signaling by the Eps15 homology domain-containing protein 3 (EHD3)

https://doi.org/10.18632/oncotarget.13008

Mohamed Amessou, Abdul Shukkur Ebrahim, Ashok Dilly, Melvin Joseph, Marina Tabolina, Sahiti Chukkapalli, Louay Meroueh, Joseph T. Syed, Allison Liddane, Siera Lanae Lang, Ayad Al-Katib,  and Mustapha Kandouz
79203-79216
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The BET bromodomain inhibitor exerts the most potent synergistic anticancer effects with quinone-containing compounds and anti-microtubule drugs

The BET bromodomain inhibitor exerts the most potent synergistic anticancer effects with quinone-containing compounds and anti-microtubule drugs

https://doi.org/10.18632/oncotarget.12640

Pei Y. Liu, Nicholas Sokolowski, Su T. Guo, Faraz Siddiqi, Bernard Atmadibrata, Thomas J. Telfer, Yuting Sun, Lihong Zhang, Denise Yu, Joshua Mccarroll, Bing Liu, Rui H. Yang, Xiang Y. Guo, Andrew E. Tee, Ken Itoh, Jenny Wang, Maria Kavallaris, Michelle Haber, Murray D. Norris, Belamy B. Cheung, Jennifer A. Byrne, David S. Ziegler, Glenn M. Marshall, Marcel E. Dinger, Rachel Codd, Xu D. Zhang,  and Tao Liu
79217-79232
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Genetic interactions between the hedgehog co-receptors Gas1 and Boc regulate cell proliferation during murine palatogenesis

Genetic interactions between the hedgehog co-receptors Gas1 and Boc regulate cell proliferation during murine palatogenesis

https://doi.org/10.18632/oncotarget.13011

Guilherme M. Xavier, Maisa Seppala, Spyridon N. Papageorgiou, Chen-Ming Fan,  and Martyn T. Cobourne
79233-79246
Abstract  |  PDF  |  HTML  |  Order a Reprint

Resveratrol post-treatment protects against neonatal brain injury after hypoxia-ischemia

Resveratrol post-treatment protects against neonatal brain injury after hypoxia-ischemia

https://doi.org/10.18632/oncotarget.13018

Shulin Pan, Songlin Li, Yingying Hu, Hao Zhang, Yanlong Liu, Huai Jiang, Mingchu Fang, Zhengmao Li, Kebin Xu, Hongyu Zhang, Zhenlang Lin,  and Jian Xiao
79247-79261
Abstract  |  PDF  |  HTML  |  Order a Reprint

Notch1-WISP-1 axis determines the regulatory role of mesenchymal stem cell-derived stromal fibroblasts in melanoma metastasis

Notch1-WISP-1 axis determines the regulatory role of mesenchymal stem cell-derived stromal fibroblasts in melanoma metastasis

https://doi.org/10.18632/oncotarget.13021

Hongwei Shao, Long Cai, Mecker Moller, Biju Issac, Leiming Zhang, Mark Owyong, Anna Elizabeth Moscowitz, Roberto Vazquez-Padron, Freddy Radtke,  and Zhao-Jun Liu
79262-79273
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Differentially expressed miRNAs in triple negative breast cancer between African-American and non-Hispanic white women

Differentially expressed miRNAs in triple negative breast cancer between African-American and non-Hispanic white women

https://doi.org/10.18632/oncotarget.13024

Bruna Sugita, Mandeep Gill, Akanskha Mahajan, Anju Duttargi, Saurabh Kirolikar, Rodrigo Almeida, Kenny Regis, Olusayo L. Oluwasanmi, Fabio Marchi, Catalin Marian, Kepher Makambi, Bhaskar Kallakury, Laura Sheahan, Iglenir J. Cavalli, Enilze M. Ribeiro, Subha Madhavan, Simina Boca, Yuriy Gusev,  and Luciane R. Cavalli
79274-79291
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Targeting heterogeneity of adrenocortical carcinoma: Evaluation and extension of preclinical tumor models to improve clinical translation

Targeting heterogeneity of adrenocortical carcinoma: Evaluation and extension of preclinical tumor models to improve clinical translation

https://doi.org/10.18632/oncotarget.12685

Constanze Hantel, Igor Shapiro, Giada Poli, Costanza Chiapponi, Martin Bidlingmaier, Martin Reincke, Michaela Luconi, Sara Jung,  and Felix Beuschlein
79292-79304
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Lentivirus-mediated RNAi knockdown of insulin-like growth factor-1 receptor inhibits the growth and invasion of hepatocellular carcinoma via down-regulating midkine expression

Lentivirus-mediated RNAi knockdown of insulin-like growth factor-1 receptor inhibits the growth and invasion of hepatocellular carcinoma via down-regulating midkine expression

https://doi.org/10.18632/oncotarget.13027

Cai Qun Bie, Xu You Liu, Ming Rong Cao, Qiu Yan Huang, Hui Jun Tang, Min Wang, Guo Li Cao, Ting Zhuang Yi, Sheng Lan Wu, Wei Jie Xu,  and Shao Hui Tang
79305-79318
Abstract  |  PDF  |  HTML  |  Order a Reprint

Downregulation of osteoprotegerin expression in metastatic colorectal carcinoma predicts recurrent metastasis and poor prognosis

Downregulation of osteoprotegerin expression in metastatic colorectal carcinoma predicts recurrent metastasis and poor prognosis

https://doi.org/10.18632/oncotarget.12686

Ahrim Moon, Sung-Im Do, Hyun-Soo Kim,  and Youn-Wha Kim
79319-79326
Abstract  |  PDF  |  HTML  |  Order a Reprint

Preclinical activity of MBM-5 in gastrointestinal cancer by inhibiting NEK2 kinase activity

Preclinical activity of MBM-5 in gastrointestinal cancer by inhibiting NEK2 kinase activity

https://doi.org/10.18632/oncotarget.12687

Yanfen Fang, Yannan Kong, Jianbei Xi, Mengli Zhu, Tong Zhu, Tongtong Jiang, Wenhao Hu, Mingliang Ma,  and Xiongwen Zhang
79327-79341
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

DNMT3B in vitro knocking-down is able to reverse embryonal rhabdomyosarcoma cell phenotype through inhibition of proliferation and induction of myogenic differentiation

DNMT3B in vitro knocking-down is able to reverse embryonal rhabdomyosarcoma cell phenotype through inhibition of proliferation and induction of myogenic differentiation

https://doi.org/10.18632/oncotarget.12688

Francesca Megiorni, Simona Camero, Simona Ceccarelli, Heather P. McDowell, Olga Mannarino, Francesco Marampon, Barry Pizer, Rajeev Shukla, Antonio Pizzuti, Cinzia Marchese, Anna Clerico,  and Carlo Dominici
79342-79356
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Intravoxel incoherent motion (IVIM) in diffusion-weighted imaging (DWI) for Hepatocellular carcinoma: correlation with histologic grade

Intravoxel incoherent motion (IVIM) in diffusion-weighted imaging (DWI) for Hepatocellular carcinoma: correlation with histologic grade

https://doi.org/10.18632/oncotarget.12689

Vincenza Granata, Roberta Fusco, Orlando Catalano, Benedetta Guarino, Francesco Granata, Fabiana Tatangelo, Antonio Avallone, Mauro Piccirillo, Raffaele Palaia, Francesco Izzo,  and Antonella Petrillo
79357-79364
Abstract  |  PDF  |  HTML  |  Order a Reprint

Association between miR-199a rs74723057 and MET rs1621 polymorphisms and the risk of hepatocellular carcinoma

Association between miR-199a rs74723057 and MET rs1621 polymorphisms and the risk of hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.13033

Qianqian Wang, Xiangyuan Yu, Qiang Li, Linyuan Qin, Shengkui Tan, Xiaoyun Zeng, Xiaoqiang Qiu, Bo Tang, Junfei Jin, Weijia Liao, Moqin Qiu, Lijun Tan, Gaofeng He, Xiaomei Li, Songqing He,  and Hongping Yu
79365-79371
Abstract  |  PDF  |  HTML  |  Order a Reprint

A combined gene expression and functional study reveals the crosstalk between N-Myc and differentiation-inducing microRNAs in neuroblastoma cells

A combined gene expression and functional study reveals the crosstalk between N-Myc and differentiation-inducing microRNAs in neuroblastoma cells

https://doi.org/10.18632/oncotarget.12676

Zhenze Zhao, Xiuye Ma, Spencer D. Shelton, Derek C. Sung, Monica Li, Daniel Hernandez, Maggie Zhang, Michael D. Losiewiz, Yidong Chen, Alexander Pertsemlidis, Xiaojie Yu, Yuanhang Liu,  and Liqin Du
79372-79387
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

ON 01910.Na (rigosertib) inhibits PI3K/Akt pathway and activates oxidative stress signals in head and neck cancer cell lines

ON 01910.Na (rigosertib) inhibits PI3K/Akt pathway and activates oxidative stress signals in head and neck cancer cell lines

https://doi.org/10.18632/oncotarget.12692

Anil Prasad, Nagina Khudaynazar, Ramana V. Tantravahi, Amanda M. Gillum,  and Benjamin S. Hoffman
79388-79400
Abstract  |  PDF  |  HTML  |  Order a Reprint

Delivery of a peptide-drug conjugate targeting the blood brain barrier improved the efficacy of paclitaxel against glioma

Delivery of a peptide-drug conjugate targeting the blood brain barrier improved the efficacy of paclitaxel against glioma

https://doi.org/10.18632/oncotarget.12708

Ying Li, Xuemin Zheng, Min Gong,  and Jianning Zhang
79401-79407
Abstract  |  PDF  |  HTML  |  Order a Reprint

Near-infrared photoimmunotherapy with galactosyl serum albumin in a model of diffuse peritoneal disseminated ovarian cancer

Near-infrared photoimmunotherapy with galactosyl serum albumin in a model of diffuse peritoneal disseminated ovarian cancer

https://doi.org/10.18632/oncotarget.12710

Toshiko Harada, Yuko Nakamura, Kazuhide Sato, Tadanobu Nagaya, Shuhei Okuyama, Fusa Ogata, Peter L. Choyke,  and Hisataka Kobayashi
79408-79416
Abstract  |  PDF  |  HTML  |  Order a Reprint

Identification of DNA-PKcs as a primary resistance factor of salinomycin in osteosarcoma cells

Identification of DNA-PKcs as a primary resistance factor of salinomycin in osteosarcoma cells

https://doi.org/10.18632/oncotarget.12712

Yun-fang Zhen, Song-tao Li, Yun-rong Zhu, Xiao-dong Wang, Xiao-zhong Zhou,  and Lun-qing Zhu
79417-79427
Abstract  |  PDF  |  HTML  |  Order a Reprint

Targeted NGS, array-CGH, and patient-derived tumor xenografts for precision medicine in advanced breast cancer: a single-center prospective study

Targeted NGS, array-CGH, and patient-derived tumor xenografts for precision medicine in advanced breast cancer: a single-center prospective study

https://doi.org/10.18632/oncotarget.12714

Anthony Gonçalves, François Bertucci, Arnaud Guille, Severine Garnier, José Adelaide, Nadine Carbuccia, Oliver Cabaud, Pascal Finetti, Serge Brunelle, Gilles Piana, Jeanne Tomassin-Piana, Maria Paciencia, Eric Lambaudie, Cornel Popovici, Renaud Sabatier, Carole Tarpin, Magali Provansal, Jean-Marc Extra, François Eisinger, Hagay Sobol, Patrice Viens, Marc Lopez, Christophe Ginestier, Emmanuelle Charafe-Jauffret, Max Chaffanet,  and Daniel Birnbaum
79428-79441
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Effect of marital status on the survival of patients with hepatocellular carcinoma treated with surgical resection: an analysis of 13,408 patients in the surveillance, epidemiology, and end results (SEER) database

Effect of marital status on the survival of patients with hepatocellular carcinoma treated with surgical resection: an analysis of 13,408 patients in the surveillance, epidemiology, and end results (SEER) database

https://doi.org/10.18632/oncotarget.12722

Chao Wu, Ping Chen, Jian-Jun Qian, Sheng-Jie Jin, Jie Yao, Xiao-Dong Wang, Dou-Sheng Bai,  and Guo-Qing Jiang
79442-79452
Abstract  |  PDF  |  HTML  |  Order a Reprint

Investigating the mechanism of hepatocellular carcinoma progression by constructing genetic and epigenetic networks using NGS data identification and big database mining method

Investigating the mechanism of hepatocellular carcinoma progression by constructing genetic and epigenetic networks using NGS data identification and big database mining method

https://doi.org/10.18632/oncotarget.13100

Cheng-Wei Li, Ping-Yao Chang,  and Bor-Sen Chen
79453-79473
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Utilization of leukapheresis and CD4 positive selection in Treg isolation and the ex-vivo expansion for a clinical application in transplantation and autoimmune disorders

Utilization of leukapheresis and CD4 positive selection in Treg isolation and the ex-vivo expansion for a clinical application in transplantation and autoimmune disorders

https://doi.org/10.18632/oncotarget.13101

Karolina Gołąb, Randall Grose, Piotr Trzonkowski, Amittha Wickrema, Martin Tibudan, Natalia Marek-Trzonkowska, Sabrina Matosz, Julia Solomina, Diane Ostrega, J. Michael Millis,  and Piotr Witkowski
79474-79484
Abstract  |  PDF  |  HTML  |  Order a Reprint

OutLyzer: software for extracting low-allele-frequency tumor mutations from sequencing background noise in clinical practice

OutLyzer: software for extracting low-allele-frequency tumor mutations from sequencing background noise in clinical practice

https://doi.org/10.18632/oncotarget.13103

Etienne Muller, Nicolas Goardon, Baptiste Brault, Antoine Rousselin, Germain Paimparay, Angelina Legros, Robin Fouillet, Olivia Bruet, Aurore Tranchant, Florian Domin, Chankannira San, Céline Quesnelle, Thierry Frebourg, Agathe Ricou, Sophie Krieger, Dominique Vaur,  and Laurent Castera
79485-79493
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Identification of KLK10 as a therapeutic target to reverse trastuzumab resistance in breast cancer

Identification of KLK10 as a therapeutic target to reverse trastuzumab resistance in breast cancer

https://doi.org/10.18632/oncotarget.13104

Zhuo Wang, Beihong Ruan, Yi Jin, Yulong Zhang, Jiaqiu Li, Liyuan Zhu, Wenxia Xu, Lifeng Feng, Hongchuan Jin,  and Xian Wang
79494-79502
Abstract  |  PDF  |  HTML  |  Order a Reprint

KRAS-mutation status dependent effect of zoledronic acid in human non-small cell cancer preclinical models

KRAS-mutation status dependent effect of zoledronic acid in human non-small cell cancer preclinical models

https://doi.org/10.18632/oncotarget.12806

István Kenessey, Krisztina Kói, Orsolya Horváth, Mihály Cserepes, Dávid Molnár, Vera Izsák, Judit Dobos, Balázs Hegedűs, József Tóvári,  and József Tímár
79503-79514
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Deubiquitinase USP9X deubiquitinates β-catenin and promotes high grade glioma cell growth

Deubiquitinase USP9X deubiquitinates β-catenin and promotes high grade glioma cell growth

https://doi.org/10.18632/oncotarget.12819

Bo Yang, Shiming Zhang, Zhihao Wang, Chunxu Yang, Wen Ouyang, Fuxiang Zhou, Yunfeng Zhou,  and Conghua Xie
79515-79525
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

In pursuit of synergy: An investigation of the PI3K/mTOR/MEK co-targeted inhibition strategy in NSCLC

In pursuit of synergy: An investigation of the PI3K/mTOR/MEK co-targeted inhibition strategy in NSCLC

https://doi.org/10.18632/oncotarget.12755

Susan Heavey, Sinead Cuffe, Stephen Finn, Vincent Young, Ronan Ryan, Siobhan Nicholson, Niamh Leonard, Niall McVeigh, Martin Barr, Kenneth O’Byrne,  and Kathy Gately
79526-79543
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

WM130 preferentially inhibits hepatic cancer stem-like cells by suppressing AKT/GSK3β/β-catenin signaling pathway

WM130 preferentially inhibits hepatic cancer stem-like cells by suppressing AKT/GSK3β/β-catenin signaling pathway

https://doi.org/10.18632/oncotarget.12822

Chen-Xu Ni, Yang Qi, Jin Zhang, Ying Liu, Wei-Heng Xu, Jing Xu, Hong-Gang Hu, Qiu-Ye Wu, Yan Wang,  and Jun-Ping Zhang
79544-79556
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Epigallocatechin-3-gallate(EGCG) suppresses melanoma cell growth and metastasis by targeting TRAF6 activity

Epigallocatechin-3-gallate(EGCG) suppresses melanoma cell growth and metastasis by targeting TRAF6 activity

https://doi.org/10.18632/oncotarget.12836

Jianglin Zhang, Zhou Lei, Zunnan Huang, Xu Zhang, Youyou Zhou, Zhongling Luo, Weiqi Zeng, Juan Su, Cong Peng,  and Xiang Chen
79557-79571
Abstract  |  PDF  |  HTML  |  Order a Reprint

Stimulation of prolactin receptor induces STAT-5 phosphorylation and cellular invasion in glioblastoma multiforme

Stimulation of prolactin receptor induces STAT-5 phosphorylation and cellular invasion in glioblastoma multiforme

https://doi.org/10.18632/oncotarget.12840

Amira Alkharusi, Shengze Yu, Natalia Landázuri, Fahad Zadjali, Belghis Davodi, Thomas Nyström, Torbjörn Gräslund, Afsar Rahbar,  and Gunnar Norstedt
79572-79583
Abstract  |  PDF  |  HTML  |  Order a Reprint

MicroRNA-101 reverses temozolomide resistance by inhibition of GSK3β in glioblastoma

MicroRNA-101 reverses temozolomide resistance by inhibition of GSK3β in glioblastoma

https://doi.org/10.18632/oncotarget.12861

Tian Tian, Ma Mingyi, Xia Qiu,  and Yang Qiu
79584-79595
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

DIRC3 and near NABP1 genetic polymorphisms are associated laryngeal squamous cell carcinoma patient survival

DIRC3 and near NABP1 genetic polymorphisms are associated laryngeal squamous cell carcinoma patient survival

https://doi.org/10.18632/oncotarget.12865

Zhen Shen, Wanli Ren, Yanxia Bai, Zhengshuai Chen, Jingjie Li, Bin Li, Tianbo Jin, Peilong Cao,  and Yuan Shao
79596-79604
Abstract  |  PDF  |  HTML  |  Order a Reprint

Comparison of the expression and function of Lin28A and Lin28B in colon cancer

Comparison of the expression and function of Lin28A and Lin28B in colon cancer

https://doi.org/10.18632/oncotarget.12869

Tianzhen Wang, Yan He, Yuanyuan Zhu, Mingwei Chen, Mingjiao Weng, Chao Yang, Yan Zhang, Ning Ning, Ran Zhao, Weiwei Yang, Yinji Jin, Jing Li, Riju James Rajkumar Ezakiel Redpath1, Lei Zhang, Xiaoming Jin, Zhaohua Zhong, Fengmin Zhang, Yunwei Wei, Guomin Shen, Dong Wang, Ying Liu, Guangyu Wang,  and Xiaobo Li
79605-79616
Abstract  |  PDF  |  HTML  |  Order a Reprint

miR-31 affects colorectal cancer cells by inhibiting autophagy in cancer-associated fibroblasts

miR-31 affects colorectal cancer cells by inhibiting autophagy in cancer-associated fibroblasts

https://doi.org/10.18632/oncotarget.12873

Xiaodong Yang, Xiaohui Xu, Junjia Zhu, Gang Zhou, Yong Wu, Yongyou Wu, Kui Zhao, Chungen Xing, Jianping Cao, Hong Zhu, Ming Li, Zhenyu Ye,  and Wei Peng
79617-79628
Abstract  |  PDF  |  HTML  |  Order a Reprint

Multiple mutations of lung squamous cell carcinoma shared common mechanisms

Multiple mutations of lung squamous cell carcinoma shared common mechanisms

https://doi.org/10.18632/oncotarget.13190

Qianping Li, Junyi Hou, Zhaoyan Hu, Biao Gu,  and Yan Shi
79629-79636
Abstract  |  PDF  |  HTML  |  Order a Reprint

Therapeutic efficacy of the bromodomain inhibitor OTX015/MK-8628 in ALK-positive anaplastic large cell lymphoma: an alternative modality to overcome resistant phenotypes

Therapeutic efficacy of the bromodomain inhibitor OTX015/MK-8628 in ALK-positive anaplastic large cell lymphoma: an alternative modality to overcome resistant phenotypes

https://doi.org/10.18632/oncotarget.12876

Michela Boi, Maria Todaro, Valentina Vurchio, Shao Ning Yang, John Moon, Ivo Kwee, Andrea Rinaldi, Heng Pan, Ramona Crescenzo, Mangeng Cheng, Leandro Cerchietti, Olivier Elemento, Maria E. Riveiro, Esteban Cvitkovic, Francesco Bertoni, Giorgio Inghirami,  and the AIRC 5xMille consortium ‘Genetics-driven targeted management of lymphoid malignancies’
79637-79653
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

SIRT1 promotes metastasis of human osteosarcoma cells

SIRT1 promotes metastasis of human osteosarcoma cells

https://doi.org/10.18632/oncotarget.12916

Ning Zhang, Tao Xie, Miao Xian, Yi-Jie Wang, Heng-Yuan Li, Mei-Dan Ying,  and Zhao-Ming Ye
79654-79669
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Enhancement of 5-FU sensitivity by the proapoptotic rpL3 gene in p53 null colon cancer cells through combined polymer nanoparticles

Enhancement of 5-FU sensitivity by the proapoptotic rpL3 gene in p53 null colon cancer cells through combined polymer nanoparticles

https://doi.org/10.18632/oncotarget.13216

Annapina Russo, Sara Maiolino, Valentina Pagliara, Francesca Ungaro, Fabiana Tatangelo, Alessandra Leone, Giulia Scalia, Alfredo Budillon, Fabiana Quaglia,  and Giulia Russo
79670-79687
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Breast cancer cells obtain an osteomimetic feature via epithelial-mesenchymal transition that have undergone BMP2/RUNX2 signaling pathway induction

Breast cancer cells obtain an osteomimetic feature via epithelial-mesenchymal transition that have undergone BMP2/RUNX2 signaling pathway induction

https://doi.org/10.18632/oncotarget.12939

Cong-Cong Tan, Gui-Xi Li, Li-Duan Tan, Xin Du, Xiao-Qing Li, Rui He, Qing-Shan Wang,  and Yu-Mei Feng
79688-79705
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Increased phosphorylation of eIF2α in chronic myeloid leukemia cells stimulates secretion of matrix modifying enzymes

Increased phosphorylation of eIF2α in chronic myeloid leukemia cells stimulates secretion of matrix modifying enzymes

https://doi.org/10.18632/oncotarget.12941

Paulina Podszywalow-Bartnicka, Anna Cmoch, Magdalena Wolczyk, Lukasz Bugajski, Marta Tkaczyk, Michal Dadlez, Margaret Nieborowska-Skorska, Antonis E. Koromilas, Tomasz Skorski,  and Katarzyna Piwocka
79706-79721
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Inhibiting glutaminase in acute myeloid leukemia: metabolic dependency of selected AML subtypes

Inhibiting glutaminase in acute myeloid leukemia: metabolic dependency of selected AML subtypes

https://doi.org/10.18632/oncotarget.12944

Polina Matre, Juliana Velez, Rodrigo Jacamo, Yuan Qi, Xiaoping Su, Tianyu Cai, Steven M. Chan, Alessia Lodi, Shannon R. Sweeney, Helen Ma, Richard Eric Davis, Natalia Baran, Torsten Haferlach, Xiaohua Su, Elsa Renee Flores, Doriann Gonzalez, Sergej Konoplev, Ismael Samudio, Courtney DiNardo, Ravi Majeti, Aaron D. Schimmer, Weiqun Li, Taotao Wang, Stefano Tiziani,  and Marina Konopleva
79722-79735
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Glypican-5 suppresses Epithelial-Mesenchymal Transition of the lung adenocarcinoma by competitively binding to Wnt3a

Glypican-5 suppresses Epithelial-Mesenchymal Transition of the lung adenocarcinoma by competitively binding to Wnt3a

https://doi.org/10.18632/oncotarget.12945

Siwei Wang, Mantang Qiu, Wenjia Xia, Youtao Xu, Qixing Mao, Jie Wang, Gaochao Dong, Lin Xu, Xin Yang,  and Rong Yin
79736-79746
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Nickel chloride-induced apoptosis via mitochondria- and Fas-mediated caspase-dependent pathways in broiler chickens

Nickel chloride-induced apoptosis via mitochondria- and Fas-mediated caspase-dependent pathways in broiler chickens

https://doi.org/10.18632/oncotarget.12946

Hongrui Guo, Hengmin Cui, Jing Fang, Zhicai Zuo, Junliang Deng, Xun Wang, Ling Zhao, Bangyuan Wu, Kejie Chen,  and Jie Deng
79747-79760
Abstract  |  PDF  |  HTML  |  Order a Reprint

Volatile oil from Saussurea lappa exerts antitumor efficacy by inhibiting epithelial growth factor receptor tyrosine kinase-mediated signaling pathway in hepatocellular carcinoma

Volatile oil from Saussurea lappa exerts antitumor efficacy by inhibiting epithelial growth factor receptor tyrosine kinase-mediated signaling pathway in hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.12962

Xuejing Lin, Zhangxiao Peng, Xiaohui Fu, Chunying Liu, Yang Xu, Weidan Ji, Jianhui Fan, Lei Chen, Lin Fang, Yao Huang,  and Changqing Su
79761-79773
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Plasma glutamate carboxypeptidase is a negative regulator in liver cancer metastasis

Plasma glutamate carboxypeptidase is a negative regulator in liver cancer metastasis

https://doi.org/10.18632/oncotarget.12967

Jae-Hye Lee, Hyun-Soo Cho, Jeong-Ju Lee, Soo Young Jun, Jun-Ho Ahn, Ju-Sik Min, Ji-Yong Yoon, Min-Hyuk Choi, Su-Jin Jeon, Jung Hwa Lim, Cho-Rok Jung, Dae-Soo Kim, Hyun-Taek Kim, Valentina M. Factor, Yun-Han Lee, Snorri S. Thorgeirsson, Cheol-Hee Kim,  and Nam-Soon Kim
79774-79786
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The survival and clinicopathological differences between patients with stage IIIA and stage II rectal cancer: An analysis of 12,036 patients in the SEER database

The survival and clinicopathological differences between patients with stage IIIA and stage II rectal cancer: An analysis of 12,036 patients in the SEER database

https://doi.org/10.18632/oncotarget.12970

Ben Huang, Shaobo Mo, Liang Zhu, Tianhong Xu,  and Guoxiang Cai
79787-79796
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Novel mutations in CRB1 gene identified in a chinese pedigree with retinitis pigmentosa by targeted capture and next generation sequencing

Novel mutations in CRB1 gene identified in a chinese pedigree with retinitis pigmentosa by targeted capture and next generation sequencing

https://doi.org/10.18632/oncotarget.12971

Lan Lu, Xizhen Wang, David Lo, Jingning Weng, xiaohong Liu, Juhua Yang, Fen He, Yun Wang,  and Xuyang Liu
79797-79804
Abstract  |  PDF  |  HTML  |  Order a Reprint

MicroRNA-206 attenuates the growth and angiogenesis in non-small cell lung cancer cells by blocking the 14-3-3ζ/STAT3/HIF-1α/VEGF signaling

MicroRNA-206 attenuates the growth and angiogenesis in non-small cell lung cancer cells by blocking the 14-3-3ζ/STAT3/HIF-1α/VEGF signaling

https://doi.org/10.18632/oncotarget.12972

Dong Xue, Ye Yang, Yawei Liu, Peiwen Wang, Yi Dai, Qinqiang Liu, Lijun Chen, Jian Shen, Huanyu Ju, Yuan Li,  and Zhenguo Tan
79805-79813
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Orthoreovirus outer-fiber proteins are substrates for SUMO-conjugating enzyme Ubc9

Orthoreovirus outer-fiber proteins are substrates for SUMO-conjugating enzyme Ubc9

https://doi.org/10.18632/oncotarget.12973

Fei Yu, Hao Wang, Longlong Wang,  and Liqun Lu
79814-79827
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Recombinant oncolytic poliovirus, PVSRIPO, has potent cytotoxic and innate inflammatory effects, mediating therapy in human breast and prostate cancer xenograft models

Recombinant oncolytic poliovirus, PVSRIPO, has potent cytotoxic and innate inflammatory effects, mediating therapy in human breast and prostate cancer xenograft models

https://doi.org/10.18632/oncotarget.12975

Eda K. Holl, Michael C. Brown, David Boczkowski, Megan A. McNamara, Daniel J. George, Darell D. Bigner, Matthias Gromeier,  and Smita K. Nair
79828-79841
Abstract  |  PDF  |  HTML  |  Order a Reprint

Synergistic effects of selective inhibitors targeting the PI3K/AKT/mTOR pathway or NUP214-ABL1 fusion protein in human Acute Lymphoblastic Leukemia

Synergistic effects of selective inhibitors targeting the PI3K/AKT/mTOR pathway or NUP214-ABL1 fusion protein in human Acute Lymphoblastic Leukemia

https://doi.org/10.18632/oncotarget.13035

Carolina Simioni, Simona Ultimo, Alberto M. Martelli, Giorgio Zauli, Daniela Milani, James A. McCubrey, Silvano Capitani,  and Luca M. Neri
79842-79853
Abstract  |  PDF  |  HTML  |  Order a Reprint

TRIM71 suppresses tumorigenesis via modulation of Lin28B-let-7-HMGA2 signaling

TRIM71 suppresses tumorigenesis via modulation of Lin28B-let-7-HMGA2 signaling

https://doi.org/10.18632/oncotarget.13036

Jinlong Yin, Tae-Hoon Kim, Nayun Park, Daye Shin, Hae In Choi, Sungchan Cho, Jong Bae Park,  and Jong Heon Kim
79854-79868
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

RSK2 activity mediates glioblastoma invasiveness and is a potential target for new therapeutics

RSK2 activity mediates glioblastoma invasiveness and is a potential target for new therapeutics

https://doi.org/10.18632/oncotarget.13084

Florian J. Sulzmaier, Shirley Young-Robbins, Pengfei Jiang, Dirk Geerts, Amanda M. Prechtl, Michelle L. Matter L. Matter, Santosh Kesari,  and Joe W. Ramos
79869-79884
Abstract  |  PDF  |  HTML  |  Order a Reprint

Cellular effects of fluorodeoxyglucose: Global changes in the lipidome and alteration in intracellular transport

Cellular effects of fluorodeoxyglucose: Global changes in the lipidome and alteration in intracellular transport

https://doi.org/10.18632/oncotarget.13089

Simona Kavaliauskiene, Maria Lyngaas Torgersen, Anne Berit Dyve Lingelem, Tove Irene Klokk, Tuulia Lintonen, Helena Simolin, Kim Ekroos, Tore Skotland,  and Kirsten Sandvig
79885-79900
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Tumor necrosis factor-alpha promoter polymorphism 308 G/A is not significantly associated with esophageal cancer risk: a meta-analysis

Tumor necrosis factor-alpha promoter polymorphism 308 G/A is not significantly associated with esophageal cancer risk: a meta-analysis

https://doi.org/10.18632/oncotarget.13093

Ming Luo, Yuan Yang, Dongmei Luo, Liang Liu, Yuening Zhang, Feifan Xiao, Jingcheng Yang, Chengdong Zhang, Shen Fu,  and Zhiguo Luo
79901-79913
Abstract  |  PDF  |  HTML  |  Order a Reprint

Interleukin-13 suppresses interleukin-10 via inhibiting A20 in peripheral B cells of patients with food allergy

Interleukin-13 suppresses interleukin-10 via inhibiting A20 in peripheral B cells of patients with food allergy

https://doi.org/10.18632/oncotarget.13107

Ming-yang Li, Min Zhu, En-qiang Linghu, Fan Feng, Bing Zhu, Cheng Wu,  and Ming-zhou Guo
79914-79924
Abstract  |  PDF  |  HTML  |  Order a Reprint

CD99 triggering induces methuosis of Ewing sarcoma cells through IGF-1R/RAS/Rac1 signaling

CD99 triggering induces methuosis of Ewing sarcoma cells through IGF-1R/RAS/Rac1 signaling

https://doi.org/10.18632/oncotarget.13160

Maria Cristina Manara, Mario Terracciano, Caterina Mancarella, Marika Sciandra, Clara Guerzoni, Michela Pasello, Andrea Grilli, Nicoletta Zini, Piero Picci, Mario P. Colombo, Andrea Morrione,  and Katia Scotlandi
79925-79942
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

PD-L1 promoter methylation is a prognostic biomarker for biochemical recurrence-free survival in prostate cancer patients following radical prostatectomy

PD-L1 promoter methylation is a prognostic biomarker for biochemical recurrence-free survival in prostate cancer patients following radical prostatectomy

https://doi.org/10.18632/oncotarget.13161

Heidrun Gevensleben, Emily Eva Holmes, Diane Goltz, Jörn Dietrich, Verena Sailer, Jörg Ellinger, Dimo Dietrich,  and Glen Kristiansen
79943-79955
Abstract  |  PDF  |  HTML  |  Order a Reprint

miR-186 affects the proliferation, invasion and migration of human gastric cancer by inhibition of Twist1

miR-186 affects the proliferation, invasion and migration of human gastric cancer by inhibition of Twist1

https://doi.org/10.18632/oncotarget.13182

Chunhong Cao, Deguang Sun, Liang Zhang,  and Lei Song
79956-79963
Abstract  |  PDF  |  HTML  |  Order a Reprint

Motor activity of centromere-associated protein-E contributes to its localization at the center of the midbody to regulate cytokinetic abscission

Motor activity of centromere-associated protein-E contributes to its localization at the center of the midbody to regulate cytokinetic abscission

https://doi.org/10.18632/oncotarget.13206

Akihiro Ohashi, Momoko Ohori,  and Kenichi Iwai
79964-79980
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Establishment of mitochondrial pyruvate carrier 1 (MPC1) gene knockout mice with preliminary gene function analyses

Establishment of mitochondrial pyruvate carrier 1 (MPC1) gene knockout mice with preliminary gene function analyses

https://doi.org/10.18632/oncotarget.13210

Xiaoli Li, Yaqing Li, Gaoyang Han, Xiaoran Li, Yasai Ji, Zhirui Fan, Yali Zhong, Jing Cao, Jing Zhao, Goscinski Mariusz, Mingzhi Zhang, Jianguo Wen, Jahn M. Nesland,  and Zhenhe Suo
79981-79994
Abstract  |  PDF  |  HTML  |  Order a Reprint

Mitomycin C treatment induces resistance and enhanced migration via phosphorylated Akt in aggressive lung cancer cells

Mitomycin C treatment induces resistance and enhanced migration via phosphorylated Akt in aggressive lung cancer cells

https://doi.org/10.18632/oncotarget.13237

Cheng-Ying Shen, Li-Han Chen, Yu-Fen Lin, Liang-Chuan Lai, Eric Y. Chuang,  and Mong-Hsun Tsai
79995-80007
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Biodegradable double-targeted PTX-mPEG-PLGA nanoparticles for ultrasound contrast enhanced imaging and antitumor therapy in vitro

Biodegradable double-targeted PTX-mPEG-PLGA nanoparticles for ultrasound contrast enhanced imaging and antitumor therapy in vitro

https://doi.org/10.18632/oncotarget.13243

Jing Ma, Ming Shen, Chang Song Xu, Ying Sun, You Rong Duan,  and Lian Fang Du
80008-80018
Abstract  |  PDF  |  HTML  |  Order a Reprint

Diagnostic accuracy of DNA methylation for head and neck cancer varies by sample type and number of markers tested

Diagnostic accuracy of DNA methylation for head and neck cancer varies by sample type and number of markers tested

https://doi.org/10.18632/oncotarget.12219

Xu Ji, Chao Guan, Xuejun Jiang,  and Hong Li
80019-80032
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

New combined microRNA and protein plasmatic biomarker panel for pancreatic cancer

New combined microRNA and protein plasmatic biomarker panel for pancreatic cancer

https://doi.org/10.18632/oncotarget.12406

Wei Yuan, Wanyan Tang, Yibin Xie, Shaoming Wang, Yingtai Chen, Jun Qi, Youlin Qiao,  and Jie Ma
80033-80045
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Clinical Research Papers

First-in-human phase I clinical trial of RG7356, an anti-CD44 humanized antibody, in patients with advanced, CD44-expressing solid tumors

First-in-human phase I clinical trial of RG7356, an anti-CD44 humanized antibody, in patients with advanced, CD44-expressing solid tumors

https://doi.org/10.18632/oncotarget.11098

C. Willemien Menke-van der Houven van Oordt, Carlos Gomez-Roca, Carla van Herpen, Andrew L. Coveler, Devalingam Mahalingam, Henk M. W. Verheul, Winette T. A. van der Graaf, Randolph Christen, Dominik Rüttinger, Stefan Weigand, Michael A. Cannarile, Florian Heil, Michael Brewster, Antje-Christine Walz, Tapan K. Nayak, Ernesto Guarin, Valerie Meresse,  and Christophe Le Tourneau
80046-80058
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Serological immune response against ADAM10 pro-domain is associated with favourable prognosis in stage III colorectal cancer patients

Serological immune response against ADAM10 pro-domain is associated with favourable prognosis in stage III colorectal cancer patients

https://doi.org/10.18632/oncotarget.11181

Sheila María Álvarez-Fernández, Marco Barbariga, Luca Cannizzaro, Carlo Vittorio Cannistraci, Laura Hurley, Alan Zanardi, Antonio Conti, Francesca Sanvito, Anna Innocenzi, Nicolò Pecorelli, Marco Braga,  and Massimo Alessio
80059-80076
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Adjuvant radiation therapy in stage I seminoma: 20 years of oncologic results

Adjuvant radiation therapy in stage I seminoma: 20 years of oncologic results

https://doi.org/10.18632/oncotarget.11374

Francesca De Felice, Daniela Musio, Giovanni Luca Gravina, Francesco Marampon,  and Vincenzo Tombolini
80077-80082
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Imatinib and polypharmacy in very old patients with chronic myeloid leukemia: effects on response rate, toxicity and outcome

Imatinib and polypharmacy in very old patients with chronic myeloid leukemia: effects on response rate, toxicity and outcome

https://doi.org/10.18632/oncotarget.11657

Alessandra Iurlo, Alessandro Nobili, Roberto Latagliata, Cristina Bucelli, Fausto Castagnetti, Massimo Breccia, Elisabetta Abruzzese, Daniele Cattaneo, Carmen Fava, Dario Ferrero, Antonella Gozzini, Massimiliano Bonifacio, Mario Tiribelli, Patrizia Pregno, Fabio Stagno, Paolo Vigneri, Mario Annunziata, Francesco Cavazzini, Gianni Binotto, Giovanna Mansueto, Sabina Russo, Franca Falzetti, Enrico Montefusco, Gabriele Gugliotta, Sergio Storti, Ada M. D’Addosio, Luigi Scaffidi, Laura Cortesi, Michele Cedrone, Antonella Russo Rossi, Paolo Avanzini, Endri Mauro, Antonio Spadea, Francesca Celesti, Gianfranco Giglio, Alessandro Isidori, Monica Crugnola, Elisabetta Calistri, Federica Sorà, Giovanna Rege-Cambrin, Simona Sica, Luigiana Luciano, Sara Galimberti, Ester M. Orlandi, Monica Bocchia, Mauro Tettamanti, Giuliana Alimena, Giuseppe Saglio, Gianantonio Rosti, Pier Mannuccio Mannucci,  and Agostino Cortelezzi
80083-80090
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Radiation combined with temozolomide contraindicated for young adults diagnosed with anaplastic glioma

Radiation combined with temozolomide contraindicated for young adults diagnosed with anaplastic glioma

https://doi.org/10.18632/oncotarget.11756

Pei Yang, Chuanbao Zhang, Jinquan Cai, Gan You, Yinyan Wang, Xiaoguang Qiu, Shouwei Li, Chenxing Wu, Kun Yao, Wenbin Li, Xiaoxia Peng, Wei Zhang,  and Tao Jiang
80091-80100
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