Oncotarget

Vol 7, No 46

November 15, 2016

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About The Cover

The cover for issue 46 of Oncotarget features Figure 2, "Immunohistochemistry reveals neuroendocrine origin of tumors in LSL-MYCN;hGFAP-Cre mice", from Fielitz et al.

Table of Contents

Priority Research Papers

Characterization of pancreatic glucagon-producing tumors and pituitary gland tumors in transgenic mice overexpressing MYCN in hGFAP-positive cells

Characterization of pancreatic glucagon-producing tumors and pituitary gland tumors in transgenic mice overexpressing MYCN in hGFAP-positive cells

https://doi.org/10.18632/oncotarget.12766

Kathrin Fielitz, Kristina Althoff, Katleen De Preter, Julie Nonnekens, Jasmin Ohli, Sandra Elges, Wolfgang Hartmann, Günter Klöppel, Thomas Knösel, Marc Schulte, Ludger Klein-Hitpass, Daniela Beisser, Annette Eyking, Elke Cario, Johannes H. Schulte, Shuang-Xi Wang, Alexander Schramm,  and Ulrich Schüller
74415-74426
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The deubiquitinase USP54 is overexpressed in colorectal cancer stem cells and promotes intestinal tumorigenesis

The deubiquitinase USP54 is overexpressed in colorectal cancer stem cells and promotes intestinal tumorigenesis

https://doi.org/10.18632/oncotarget.12769

Julia M. Fraile, Diana Campos-Iglesias, Francisco Rodríguez, Yaiza Español,  and José M.P. Freije
74427-74434
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Absence of ERK5/MAPK7 delays tumorigenesis in Atm-/- mice

Absence of ERK5/MAPK7 delays tumorigenesis in Atm-/- mice

https://doi.org/10.18632/oncotarget.12908

Alba Granados-Jaén, Maria Angulo-Ibáñez, Xavier Rovira-Clavé, Celina Paola Vasquez Gamez, Francesc X. Soriano, Manuel Reina,  and Enric Espel
74435-74447
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Kinetics, prognostic and predictive values of ESR1 circulating mutations in metastatic breast cancer patients progressing on aromatase inhibitor

Kinetics, prognostic and predictive values of ESR1 circulating mutations in metastatic breast cancer patients progressing on aromatase inhibitor

https://doi.org/10.18632/oncotarget.12950

Florian Clatot, Anne Perdrix, Laetitia Augusto, Ludivine Beaussire, Julien Delacour, Céline Calbrix, David Sefrioui, Pierre-Julien Viailly, Michael Bubenheim, Cristian Moldovan, Cristina Alexandru, Isabelle Tennevet, Olivier Rigal, Cécile Guillemet, Marianne Leheurteur, Sophie Gouérant, Camille Petrau, Jean-Christophe Théry, Jean-Michel Picquenot, Corinne Veyret, Thierry Frébourg, Fabrice Jardin, Nasrin Sarafan-Vasseur,  and Frédéric Di Fiore
74448-74459
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Research Papers: Gerotarget (Focus on Aging)

Polymorphisms of the murine mitochondrial ND4, CYTB and COX3 genes impact hematopoiesis during aging

Polymorphisms of the murine mitochondrial ND4, CYTB and COX3 genes impact hematopoiesis during aging

https://doi.org/10.18632/oncotarget.11952

Christin Kretzschmar, Catrin Roolf, Katrin Timmer, Anett Sekora, Gudrun Knübel, Hugo Murua Escobar, Georg Fuellen, Saleh M. Ibrahim, Markus Tiedge, Simone Baltrusch, Robert Jaster, Rüdiger Köhling,  and Christian Junghanss
74460-74472
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7-Ketocholesterol induces ATM/ATR, Chk1/Chk2, PI3K/Akt signalings, cytotoxicity and IL-8 production in endothelial cells

7-Ketocholesterol induces ATM/ATR, Chk1/Chk2, PI3K/Akt signalings, cytotoxicity and IL-8 production in endothelial cells

https://doi.org/10.18632/oncotarget.12578

Mei-Chi Chang, Yi-Jane Chen, Eric Jein-Wein Liou, Wan-Yu Tseng, Chiu-Po Chan, Hseuh-Jen Lin, Wan-Chuen Liao, Ya-Ching Chang, Po-Yuan Jeng,  and Jiiang-Huei Jeng
74473-74483
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Ampelopsin attenuates brain aging of D-gal-induced rats through miR-34a-mediated SIRT1/mTOR signal pathway

Ampelopsin attenuates brain aging of D-gal-induced rats through miR-34a-mediated SIRT1/mTOR signal pathway

https://doi.org/10.18632/oncotarget.12811

Xianjuan Kou, Xingran Liu, Xianbing Chen, Jie Li, Xiaoqi Yang, Jingjing Fan, Yi Yang,  and Ning Chen
74484-74495
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Patient fibroblasts-derived induced neurons demonstrate autonomous neuronal defects in adult-onset Krabbe disease

Patient fibroblasts-derived induced neurons demonstrate autonomous neuronal defects in adult-onset Krabbe disease

https://doi.org/10.18632/oncotarget.12812

Su Min Lim, Byung-Ok Choi, Seong-il Oh, Won Jun Choi, Ki-Wook Oh, Minyeop Nahm, Yuanchao Xue, Jae Hyeok Choi, Ji Young Choi, Young-Eun Kim, Ki Wha Chung, Xiang-Dong Fu, Chang-Seok Ki,  and Seung Hyun Kim
74496-74509
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Long-term exposure to air pollution is associated with biological aging

Long-term exposure to air pollution is associated with biological aging

https://doi.org/10.18632/oncotarget.12903

Cavin K. Ward-Caviness, Jamaji C. Nwanaji-Enwerem, Kathrin Wolf, Simone Wahl, Elena Colicino, Letizia Trevisi, Itai Kloog, Allan C. Just, Pantel Vokonas, Josef Cyrys, Christian Gieger, Joel Schwartz, Andrea A. Baccarelli, Alexandra Schneider,  and Annette Peters
74510-74525
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G6PC3, ALDOA and CS induction accompanies mir-122 down-regulation in the mechanical asphyxia and can serve as hypoxia biomarkers

G6PC3, ALDOA and CS induction accompanies mir-122 down-regulation in the mechanical asphyxia and can serve as hypoxia biomarkers

https://doi.org/10.18632/oncotarget.12931

Yan Zeng, Yehui Lv, Li Tao, Jianlong Ma, Heng Zhang, Hongmei Xu, Bi Xiao, Qun Shi, Kaijun Ma,  and Long Chen
74526-74536
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Research Papers: Pathology

Intravenous administration of xenogenic adipose-derived mesenchymal stem cells (ADMSC) and ADMSC-derived exosomes markedly reduced brain infarct volume and preserved neurological function in rat after acute ischemic stroke

Intravenous administration of xenogenic adipose-derived mesenchymal stem cells (ADMSC) and ADMSC-derived exosomes markedly reduced brain infarct volume and preserved neurological function in rat after acute ischemic stroke

https://doi.org/10.18632/oncotarget.12902

Kuan-Hung Chen, Chih-Hung Chen, Christopher Glenn Wallace, Chun-Man Yuen, Gour-Shenq Kao, Yi-Ling Chen, Pei-Lin Shao, Yung-Lung Chen, Han-Tan Chai, Kun-Chen Lin, Chu-Feng Liu, Hsueh-Wen Chang, Mel S. Lee,  and Hon-Kan Yip
74537-74556
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Beauveria attenuates asthma by inhibiting inflammatory response and inducing lymphocytic cell apoptosis

Beauveria attenuates asthma by inhibiting inflammatory response and inducing lymphocytic cell apoptosis

https://doi.org/10.18632/oncotarget.12958

Jingying Zhang, Xianmei Zhou,  and Jiping Zhu
74557-74568
Abstract  |  PDF  |  HTML  |  Order a Reprint

Research Papers: Immunology

MiR-185/AKT and miR-29a/Collagen 1a pathways are activated in IPF BAL cells

MiR-185/AKT and miR-29a/Collagen 1a pathways are activated in IPF BAL cells

https://doi.org/10.18632/oncotarget.12740

Eliza Tsitoura, Athol U. Wells, Kostantinos Karagiannis, Ismini Lasithiotaki, Eirini Vasarmidi, Eleni Bibaki, Chara Koutoulaki, Hiroe Sato, Demetrios A. Spandidos, Nikolaos M. Siafakas, George Sourvinos,  and Katerina M. Antoniou
74569-74581
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Quantitative proteomics reveals Piccolo as a candidate serological correlate of recovery from Guillain-Barré syndrome

Quantitative proteomics reveals Piccolo as a candidate serological correlate of recovery from Guillain-Barré syndrome

https://doi.org/10.18632/oncotarget.12789

Lourdes Mateos-Hernández, Margarita Villar, Ernesto Doncel-Pérez, Marco Trevisan-Herraz, Ángel García-Forcada, Francisco Romero Ganuza, Jesús Vázquez,  and José de la Fuente
74582-74591
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Toll-like receptor agonists partially restore the production of pro-inflammatory cytokines and type I interferon in Sézary syndrome

Toll-like receptor agonists partially restore the production of pro-inflammatory cytokines and type I interferon in Sézary syndrome

https://doi.org/10.18632/oncotarget.12816

Kelly C. G. Manfrere, Marina P. Torrealba, Denis R. Miyashiro, Luanda M. S. Oliveira, Gabriel C. de Carvalho, Josenilson F. Lima, Anna Claudia C. C. Branco, Nátalli Z. Pereira, Juliana Pereira, José A. Sanches, Jr,  and Maria N. Sato
74592-74601
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Exogenous cathepsin G upregulates cell surface MHC class I molecules on immune and glioblastoma cells

Exogenous cathepsin G upregulates cell surface MHC class I molecules on immune and glioblastoma cells

https://doi.org/10.18632/oncotarget.12980

Madleen Giese, Nadine Turiello, Nicole Molenda, David Palesch, Annika Meid, Roman Schroeder, Paola Basilico, Charaf Benarafa, Marc-Eric Halatsch, Michal Zimecki, Mike-Andrew Westhoff, Christian Rainer Wirtz,  and Timo Burster
74602-74611
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Research Papers: Autophagy and Cell Death

Fyn phosphorylates AMPK to inhibit AMPK activity and AMP-dependent activation of autophagy

Fyn phosphorylates AMPK to inhibit AMPK activity and AMP-dependent activation of autophagy

https://doi.org/10.18632/oncotarget.11916

Eijiro Yamada, Shuichi Okada, Claire C. Bastie, Manu Vatish, Yasuyo Nakajima, Ryo Shibusawa, Atsushi Ozawa, Jeffrey E. Pessin,  and Masanobu Yamada
74612-74629
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Research Papers

Temozolomide toxicity operates in a xCT/SLC7a11 dependent manner and is fostered by ferroptosis

Temozolomide toxicity operates in a xCT/SLC7a11 dependent manner and is fostered by ferroptosis

https://doi.org/10.18632/oncotarget.11858

Tina Sehm, Manfred Rauh, Kurt Wiendieck, Michael Buchfelder, IIker Y. Eyüpoglu,  and Nicolai E. Savaskan
74630-74647
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Hyperosmotic treatment synergistically boost efficiency of cell-permeable peptides

Hyperosmotic treatment synergistically boost efficiency of cell-permeable peptides

https://doi.org/10.18632/oncotarget.9448

Hu Wang, Ming Zhang, Fanhui Zeng,  and Changbai Liu
74648-74657
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Rapamycin ameliorates chitosan nanoparticle-induced developmental defects of preimplantation embryos in mice

Rapamycin ameliorates chitosan nanoparticle-induced developmental defects of preimplantation embryos in mice

https://doi.org/10.18632/oncotarget.10813

Yun-Jung Choi, Sangiliyandi Gurunathan, DaSom Kim, Hyung Seok Jang, Woo-Jin Park, Ssang-Goo Cho, Chankyu Park, Hyuk Song, Han Geuk Seo,  and Jin-Hoi Kim
74658-74677
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The prognostic significance of heparanase expression in metastatic melanoma

The prognostic significance of heparanase expression in metastatic melanoma

https://doi.org/10.18632/oncotarget.12492

Olga Vornicova, Ilanit Boyango, Sari Feld, Inna Naroditsky, Olga Kazarin, Yaniv Zohar, Yariv Tiram, Neta Ilan, Ofer Ben-Izhak, Israel Vlodavsky,  and Gil Bar-Sela
74678-74685
Abstract  |  PDF  |  HTML  |  Order a Reprint

Selenite promotes all-trans retinoic acid-induced maturation of acute promyelocytic leukemia cells

Selenite promotes all-trans retinoic acid-induced maturation of acute promyelocytic leukemia cells

https://doi.org/10.18632/oncotarget.12531

Sougat Misra, Arun Kumar Selvam, Marita Wallenberg, Aditya Ambati, András Matolcsy, Isabelle Magalhaes, Gilbert Lauter,  and Mikael Björnstedt
74686-74700
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Specificity and biologic activities of novel anti-membrane IgM antibodies

Specificity and biologic activities of novel anti-membrane IgM antibodies

https://doi.org/10.18632/oncotarget.12506

Rachel S. Welt, Jonathan A. Welt, David Kostyal, Yamuna D. Gangadharan, Virginia Raymond,  and Sydney Welt
74701-74723
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Nutlin-3 inhibits androgen receptor-driven c-FLIP expression, resulting in apoptosis of prostate cancer cells

Nutlin-3 inhibits androgen receptor-driven c-FLIP expression, resulting in apoptosis of prostate cancer cells

https://doi.org/10.18632/oncotarget.12542

Ian R. Logan, Urszula L. McClurg, Dominic L. Jones, Daniel J. O’Neill, Fadhel S. Shaheen, John Lunec, Luke Gaughan,  and Craig N. Robson
74724-74733
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

HNF1B variants associate with promoter methylation and regulate gene networks activated in prostate and ovarian cancer

HNF1B variants associate with promoter methylation and regulate gene networks activated in prostate and ovarian cancer

https://doi.org/10.18632/oncotarget.12543

Helen Ross-Adams, Stephen Ball, Kate Lawrenson, Silvia Halim, Roslin Russell, Claire Wells, Siri H. Strand, Torben F. Ørntoft, Melissa Larson, Sebastian Armasu, Charles E. Massie, Mohammad Asim, Martin M. Mortensen, Michael Borre, Kathryn Woodfine, Anne Y. Warren, Alastair D. Lamb, Jonathan Kay, Hayley Whitaker, Antonio Ramos-Montoya, Adele Murrell, Karina D. Sørensen, Brooke L. Fridley, Ellen L. Goode, Simon A. Gayther, John Masters, David E. Neal,  and Ian G. Mills
74734-74746
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Coordination of signalling networks and tumorigenic properties by ABL in glioblastoma cells

Coordination of signalling networks and tumorigenic properties by ABL in glioblastoma cells

https://doi.org/10.18632/oncotarget.12546

Fabienne Lamballe, Sara Toscano, Filippo Conti, Maria Arechederra, Nathalie Baeza, Dominique Figarella-Branger, Françoise Helmbacher,  and Flavio Maina
74747-74767
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Sirtuin 1 stimulates the proliferation and the expression of glycolysis genes in pancreatic neoplastic lesions

Sirtuin 1 stimulates the proliferation and the expression of glycolysis genes in pancreatic neoplastic lesions

https://doi.org/10.18632/oncotarget.11013

Andreia V. Pinho, Amanda Mawson, Anthony Gill, Mehreen Arshi, Max Warmerdam, Marc Giry-Laterriere, Nils Eling, Triyana Lie, Evelyne Kuster, Simone Camargo, Andrew V. Biankin, Jianmin Wu,  and Ilse Rooman
74768-74778
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Exocytosis of polyubiquitinated proteins in bortezomib-resistant leukemia cells: a role for MARCKS in acquired resistance to proteasome inhibitors

Exocytosis of polyubiquitinated proteins in bortezomib-resistant leukemia cells: a role for MARCKS in acquired resistance to proteasome inhibitors

https://doi.org/10.18632/oncotarget.11340

Niels E. Franke, Gertjan L. Kaspers, Yehuda G. Assaraf, Johan van Meerloo, Denise Niewerth, Floortje L. Kessler, Pino J. Poddighe, Jeroen Kole, Serge J. Smeets, Bauke Ylstra, Chonglei Bi, Wee Joo Chng, Terzah M. Horton, Rene X. Menezes, Renée J.P. Musters, Sonja Zweegman, Gerrit Jansen,  and Jacqueline Cloos
74779-74796
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Copy number gain of chromosome 3q is a recurrent event in patients with intraductal papillary mucinous neoplasm (IPMN) associated with disease progression

Copy number gain of chromosome 3q is a recurrent event in patients with intraductal papillary mucinous neoplasm (IPMN) associated with disease progression

https://doi.org/10.18632/oncotarget.11501

Sandra Durante, Silvia Vecchiarelli, Annalisa Astolfi, Elisa Grassi, Riccardo Casadei, Donatella Santini, Riccardo Panzacchi, Claudio Ricci, Salvatore Serravalle, Giuseppe Tarantino, Mirella Falconi, Gabriella Teti, Valentina Indio, Andrea Pession, Francesco Minni, Guido Biasco,  and Mariacristina Di Marco
74797-74806
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

PEITC-mediated inhibition of mRNA translation is associated with both inhibition of mTORC1 and increased eIF2α phosphorylation in established cell lines and primary human leukemia cells

PEITC-mediated inhibition of mRNA translation is associated with both inhibition of mTORC1 and increased eIF2α phosphorylation in established cell lines and primary human leukemia cells

https://doi.org/10.18632/oncotarget.11655

Alison Yeomans, Elizabeth Lemm, Sarah Wilmore, Breeze E. Cavell, Beatriz Valle-Argos, Sergey Krysov, Marina Sanchez Hidalgo, Elodie Leonard, Anne E. Willis, Francesco Forconi, Freda K. Stevenson, Andrew J. Steele, Mark J. Coldwell,  and Graham Packham
74807-74819
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Akt isoform specific effects in ovarian cancer progression

Akt isoform specific effects in ovarian cancer progression

https://doi.org/10.18632/oncotarget.11204

Nicolle M. Linnerth-Petrik, Lisa A. Santry, Roger Moorehead, Manfred Jücker, Sarah K. Wootton,  and Jim Petrik
74820-74833
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Dendritic cell-derived nitric oxide inhibits the differentiation of effector dendritic cells

Dendritic cell-derived nitric oxide inhibits the differentiation of effector dendritic cells

https://doi.org/10.18632/oncotarget.11361

Chuanping Si, Ruihua Zhang, Tianshu Wu, Geming Lu, Yuan Hu, Hui Zhang, Feihong Xu, Peter Wei, Kang Chen, Hua Tang, Garabet Yeretssian,  and Huabao Xiong
74834-74845
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Detection of cellular senescence within human invasive breast carcinomas distinguishes different breast tumor subtypes

Detection of cellular senescence within human invasive breast carcinomas distinguishes different breast tumor subtypes

https://doi.org/10.18632/oncotarget.12432

Cristina L. Cotarelo, Arno Schad, Charles James Kirkpatrick, Jonathan P. Sleeman, Erik Springer, Marcus Schmidt,  and Sonja Thaler
74846-74859
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Zinc enhances temozolomide cytotoxicity in glioblastoma multiforme model systems

Zinc enhances temozolomide cytotoxicity in glioblastoma multiforme model systems

https://doi.org/10.18632/oncotarget.11382

Tatyana Pismenyuk, Michal Yalon, Shani Freedman, Amos J. Simon, Tamar Fisher, Itai Moshe, Juergen K.V. Reichardt, Shlomi Constantini, Yael Mardor, David Last, David Guez, Dianne Daniels, Moria Assoulin,  and Ruty Mehrian-Shai
74860-74871
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Kindlin-2 interacts with β-catenin and YB-1 to enhance EGFR transcription during glioma progression

Kindlin-2 interacts with β-catenin and YB-1 to enhance EGFR transcription during glioma progression

https://doi.org/10.18632/oncotarget.12439

Yunwei Ou, Zitong Zhao, Weimin Zhang, Qingnan Wu, Chuanyue Wu, Xuefeng Liu, Ming Fu, Nan Ji, Dan Wang, Jiaji Qiu, Liwei Zhang, Chunjiang Yu, Yongmei Song,  and Qimin Zhan
74872-74885
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Neutrophilia in locally advanced cervical cancer: A novel biomarker for image-guided adaptive brachytherapy?

Neutrophilia in locally advanced cervical cancer: A novel biomarker for image-guided adaptive brachytherapy?

https://doi.org/10.18632/oncotarget.12440

Alexandre Escande, Christine Haie-Meder, Pierre Maroun, Sébastien Gouy, Renaud Mazeron, Thomas Leroy, Enrica Bentivegna, Philippe Morice, Eric Deutsch,  and Cyrus Chargari
74886-74894
Abstract  |  PDF  |  HTML  |  Order a Reprint

A three ion channel genes-based signature predicts prognosis of primary glioblastoma patients and reveals a chemotherapy sensitive subtype

A three ion channel genes-based signature predicts prognosis of primary glioblastoma patients and reveals a chemotherapy sensitive subtype

https://doi.org/10.18632/oncotarget.12462

Hao-Yuan Wang, Ji-Ye Li, Xiu Liu, Xiao-Yan Yan, Wen Wang, Fan Wu, Ting-Yu Liang, Fan Yang, Hui-Min Hu, Heng-Xu Mao, Yan-Wei Liu,  and Shi-Zhong Zhang
74895-74903
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Prognostic value of tumor infiltrating NK cells and macrophages in stage II+III esophageal cancer patients

Prognostic value of tumor infiltrating NK cells and macrophages in stage II+III esophageal cancer patients

https://doi.org/10.18632/oncotarget.12484

Bin Xu, Lujun Chen, Jing Li, Xiao Zheng, Liangrong Shi, Changping Wu,  and Jingting Jiang
74904-74916
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Autophagy mediates proteolysis of NPM1 and HEXIM1 and sensitivity to BET inhibition in AML cells

Autophagy mediates proteolysis of NPM1 and HEXIM1 and sensitivity to BET inhibition in AML cells

https://doi.org/10.18632/oncotarget.12493

Min Huang, Jacqueline S. Garcia, Daniel Thomas, Li Zhu, Le Xuan Truong Nguyen, Steven M. Chan, Ravindra Majeti, Bruno C. Medeiros,  and Beverly S. Mitchell
74917-74930
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A signaling cascade including ARID1A, GADD45B and DUSP1 induces apoptosis and affects the cell cycle of germ cell cancers after romidepsin treatment

A signaling cascade including ARID1A, GADD45B and DUSP1 induces apoptosis and affects the cell cycle of germ cell cancers after romidepsin treatment

https://doi.org/10.18632/oncotarget.11647

Daniel Nettersheim, Sina Jostes, Martin Fabry, Friedemann Honecker, Valerie Schumacher, Jutta Kirfel, Glen Kristiansen,  and Hubert Schorle
74931-74946
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Identification of the zinc finger 216 (ZNF216) in human carcinoma cells: a potential regulator of EGFR activity

Identification of the zinc finger 216 (ZNF216) in human carcinoma cells: a potential regulator of EGFR activity

https://doi.org/10.18632/oncotarget.12509

Gabriella Mincione, Maria Carmela Di Marcantonio, Chiara Tarantelli, Luca Savino, Donatella Ponti, Marco Marchisio, Paola Lanuti, Silvia Sancilio, Antonella Calogero, Roberta Di Pietro,  and Raffaella Muraro
74947-74965
Abstract  |  PDF  |  HTML  |  Order a Reprint

Periostin is identified as a putative metastatic marker in breast cancer-derived exosomes

Periostin is identified as a putative metastatic marker in breast cancer-derived exosomes

https://doi.org/10.18632/oncotarget.11663

Ioulia Vardaki, Sophia Ceder, Dorothea Rutishauser, George Baltatzis, Theodoros Foukakis,  and Theocharis Panaretakis
74966-74978
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

APOBEC3 deletion increases the risk of breast cancer: a meta-analysis

APOBEC3 deletion increases the risk of breast cancer: a meta-analysis

https://doi.org/10.18632/oncotarget.11792

Yali Han, Qichao Qi, Qin He, Meili Sun, Shuyun Wang, Guanzhou Zhou,  and Yuping Sun
74979-74986
Abstract  |  PDF  |  HTML  |  Order a Reprint

Anti-hepatocellular carcinoma properties of the anti-alcoholism drug disulfiram discovered to enzymatically inhibit the AMPK-related kinase SNARK in vitro

Anti-hepatocellular carcinoma properties of the anti-alcoholism drug disulfiram discovered to enzymatically inhibit the AMPK-related kinase SNARK in vitro

https://doi.org/10.18632/oncotarget.11820

Kaku Goto, Naoya Kato,  and Raymond T. Chung
74987-74999
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

nc886, a non-coding RNA and suppressor of PKR, exerts an oncogenic function in thyroid cancer

nc886, a non-coding RNA and suppressor of PKR, exerts an oncogenic function in thyroid cancer

https://doi.org/10.18632/oncotarget.11852

Eun Kyung Lee, Seung-Hyun Hong, Sooyong Shin, Hyun-Sung Lee, Ju-Seog Lee, Eun Jung Park, Sun Shim Choi, Jae Woong Min, Daeyoon Park, Jung-Ah Hwang, Betty H. Johnson, Sung Ho Jeon, In-Hoo Kim, Yeon-Su Lee,  and Yong Sun Lee
75000-75012
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Interleukin-6 and C-reactive protein as prognostic biomarkers in metastatic colorectal cancer

Interleukin-6 and C-reactive protein as prognostic biomarkers in metastatic colorectal cancer

https://doi.org/10.18632/oncotarget.12601

Maria Thomsen, Christian Kersten, Halfdan Sorbye, Eva Skovlund, Bengt Glimelius, Per Pfeiffer, Julia S. Johansen, Elin H. Kure, Tone Ikdahl, Kjell Magne Tveit, Thoralf Christoffersen,  and Tormod Kyrre Guren
75013-75022
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

SMYD3-mediated lysine methylation in the PH domain is critical for activation of AKT1

SMYD3-mediated lysine methylation in the PH domain is critical for activation of AKT1

https://doi.org/10.18632/oncotarget.11898

Yuichiro Yoshioka, Takehiro Suzuki, Yo Matsuo, Makoto Nakakido, Giichiro Tsurita, Cristiano Simone, Toshiaki Watanabe, Naoshi Dohmae, Yusuke Nakamura,  and Ryuji Hamamoto
75023-75037
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

miR-885-5p suppresses hepatocellular carcinoma metastasis and inhibits Wnt/β-catenin signaling pathway

miR-885-5p suppresses hepatocellular carcinoma metastasis and inhibits Wnt/β-catenin signaling pathway

https://doi.org/10.18632/oncotarget.12602

Zhuhong Zhang, Jing Yin, Jian Yang, Wenzhi Shen, Chunyan Zhang, Wenjun Mou, Jinhua Luo, Hua Yan, Peiqing Sun, Yunping Luo, Yaping Tian,  and Rong Xiang
75038-75051
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Overexpression of sulfatase-1 in murine hepatocarcinoma Hca-F cell line downregulates mesothelin and leads to reduction in lymphatic metastasis, both in vitro and in vivo

Overexpression of sulfatase-1 in murine hepatocarcinoma Hca-F cell line downregulates mesothelin and leads to reduction in lymphatic metastasis, both in vitro and in vivo

https://doi.org/10.18632/oncotarget.11933

Salma Mahmoud, Mohammed Ibrahim, Ahmed Hago, Yuhong Huang, Yuanyi Wei, Jun Zhang, Qingqing Zhang, Yu Xiao, Jingwen Wang, Munkaila Adam, Yu Guo, Li Wang, Shuting Zhou, Boyi Xin, Wei Xuan,  and Jianwu Tang
75052-75063
Abstract  |  PDF  |  HTML  |  Order a Reprint

Porcine epidemic diarrhea virus nucleoprotein contributes to HMGB1 transcription and release by interacting with C/EBP-β

Porcine epidemic diarrhea virus nucleoprotein contributes to HMGB1 transcription and release by interacting with C/EBP-β

https://doi.org/10.18632/oncotarget.11991

Chang-chao Huan, Hua-xia Wang, Xiang-xiang Sheng, Rui Wang, Xin Wang, Ying Liao, Qin-fang Liu, Guang-zhi Tong, Chan Ding, Hong-jie Fan, Jia-qiang Wu,  and Xiang Mao
75064-75080
Abstract  |  PDF  |  HTML  |  Order a Reprint

The anti-fibrotic effect of GV1001 combined with gemcitabine on treatment of pancreatic ductal adenocarcinoma

The anti-fibrotic effect of GV1001 combined with gemcitabine on treatment of pancreatic ductal adenocarcinoma

https://doi.org/10.18632/oncotarget.12057

Hyemin Kim, Yejin Kim, Jane Jeon, Tae Wan Kim, Ji-Hong Park, Young-il Hwnag, Wang Jae Lee,  and Jae Seung Kang
75081-75093
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The clinicopathologic relevance and prognostic value of tumor deposits and the applicability of N1c category in rectal cancer with preoperative radiotherapy

The clinicopathologic relevance and prognostic value of tumor deposits and the applicability of N1c category in rectal cancer with preoperative radiotherapy

https://doi.org/10.18632/oncotarget.12058

Xiao-li Wei, Miao-zhen Qiu, Yi-xin Zhou, Ming-ming He, Hui-yan Luo, Feng-hua Wang, Dong-sheng Zhang, Yu-hong Li,  and Rui-hua Xu
75094-75103
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Identification of small molecule inhibitors of ERCC1-XPF that inhibit DNA repair and potentiate cisplatin efficacy in cancer cells

Identification of small molecule inhibitors of ERCC1-XPF that inhibit DNA repair and potentiate cisplatin efficacy in cancer cells

https://doi.org/10.18632/oncotarget.12072

Sanjeevani Arora, Joshua Heyza, Hao Zhang, Vivian Kalman-Maltese, Kristin Tillison, Ashley M. Floyd, Elaine M. Chalfin, Gerold Bepler,  and Steve M. Patrick
75104-75117
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MiR-139-5p reverses CD44+/CD133+-associated multidrug resistance by downregulating NOTCH1 in colorectal carcinoma cells

MiR-139-5p reverses CD44+/CD133+-associated multidrug resistance by downregulating NOTCH1 in colorectal carcinoma cells

https://doi.org/10.18632/oncotarget.12611

Ke Xu, Ke Shen, Xin Liang, Yueqi Li, Norio Nagao, Jiyu Li, Jianwen Liu,  and Peihao Yin
75118-75129
Abstract  |  PDF  |  HTML  |  Order a Reprint

CD103+ intraepithelial T cells in high-grade serous ovarian cancer are phenotypically diverse TCRαβ+ CD8αβ+ T cells that can be targeted for cancer immunotherapy

CD103+ intraepithelial T cells in high-grade serous ovarian cancer are phenotypically diverse TCRαβ+ CD8αβ+ T cells that can be targeted for cancer immunotherapy

https://doi.org/10.18632/oncotarget.12077

Fenne L. Komdeur, Maartje C.A. Wouters, Hagma H. Workel, Aline M. Tijans, Anouk L.J. Terwindt, Kim L. Brunekreeft, Annechien Plat, Harry G. Klip, Florine A. Eggink, Ninke Leffers, Wijnand Helfrich, Douwe F. Samplonius, Edwin Bremer, G. Bea A. Wisman, Toos Daemen, Evelien W. Duiker, Harry Hollema, Hans W. Nijman,  and Marco de Bruyn
75130-75144
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Efficacy of crizotinib and pemetrexed-based chemotherapy in Chinese NSCLC patients with ROS1 rearrangement

Efficacy of crizotinib and pemetrexed-based chemotherapy in Chinese NSCLC patients with ROS1 rearrangement

https://doi.org/10.18632/oncotarget.12612

Limin Zhang, Tao Jiang, Chao Zhao, Wei Li, Xuefei Li, Sha Zhao, Xiaozhen Liu, Yijun Jia, Hui Yang, Shengxiang Ren,  and Caicun Zhou
75145-75154
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Apoptosis signal-regulating kinase 1 exhibits oncogenic activity in pancreatic cancer

Apoptosis signal-regulating kinase 1 exhibits oncogenic activity in pancreatic cancer

https://doi.org/10.18632/oncotarget.12090

Youguang Luo, Siqi Gao, Ziwei Hao, Yang Yang, Songbo Xie, Dengwen Li, Min Liu,  and Jun Zhou
75155-75164
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Waltonitone inhibits proliferation of hepatoma cells and tumorigenesis via FXR-miR-22-CCNA2 signaling pathway

Waltonitone inhibits proliferation of hepatoma cells and tumorigenesis via FXR-miR-22-CCNA2 signaling pathway

https://doi.org/10.18632/oncotarget.12614

Fan Yang, Junting Gong, Guangyun Wang, Peng Chen, Li Yang,  and Zhengtao Wang
75165-75175
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Genomic characterization of high-risk non-muscle invasive bladder cancer

Genomic characterization of high-risk non-muscle invasive bladder cancer

https://doi.org/10.18632/oncotarget.12661

Joshua J. Meeks, Benedito A. Carneiro, Sachin G. Pai, Daniel T. Oberlin, Alfred Rademaker, Kyle Fedorchak, Sohail Balasubramanian, Julia Elvin, Nike Beaubier,  and Francis J. Giles
75176-75184
Abstract  |  PDF  |  HTML  |  Order a Reprint

miR-424-5p promotes proliferation of gastric cancer by targeting Smad3 through TGF-β signaling pathway

miR-424-5p promotes proliferation of gastric cancer by targeting Smad3 through TGF-β signaling pathway

https://doi.org/10.18632/oncotarget.12092

Song Wei, Qing Li, Zheng Li, Linjun Wang, Lei Zhang,  and Zekuan Xu
75185-75196
Abstract  |  PDF  |  HTML  |  Order a Reprint

Elevated level of acetylation of APE1 in tumor cells modulates DNA damage repair

Elevated level of acetylation of APE1 in tumor cells modulates DNA damage repair

https://doi.org/10.18632/oncotarget.12113

Shiladitya Sengupta, Anil K. Mantha, Heyu Song, Shrabasti Roychoudhury, Somsubhra Nath, Sutapa Ray,  and Kishor K. Bhakat
75197-75209
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Protein tyrosine phosphatase PTP4A1 promotes proliferation and epithelial-mesenchymal transition in intrahepatic cholangiocarcinoma via the PI3K/AKT pathway

Protein tyrosine phosphatase PTP4A1 promotes proliferation and epithelial-mesenchymal transition in intrahepatic cholangiocarcinoma via the PI3K/AKT pathway

https://doi.org/10.18632/oncotarget.12116

Long-Zi Liu, Yi-Zhou He, Ping-Ping Dong, Li-Jie Ma, Zhi-Chao Wang, Xin-Yang Liu, Meng Duan, Liu-Xiao Yang, Jie-Yi Shi, Jian Zhou, Jia Fan, Qiang Gao,  and Xiao-Ying Wang
75210-75220
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Serum depletion induced cancer stem cell-like phenotype due to nitric oxide synthesis in oncogenic HRas transformed cells

Serum depletion induced cancer stem cell-like phenotype due to nitric oxide synthesis in oncogenic HRas transformed cells

https://doi.org/10.18632/oncotarget.12117

Keisuke Monji, Takeshi Uchiumi, Saki Hoshizawa, Mikako Yagi, Takashi Matsumoto, Daiki Setoyama, Yuichi Matsushima, Kazuhito Gotoh, Rie Amamoto,  and Donchon Kang
75221-75234
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Somatic polyploidy is associated with the upregulation of c-MYC interacting genes and EMT-like signature

Somatic polyploidy is associated with the upregulation of c-MYC interacting genes and EMT-like signature

https://doi.org/10.18632/oncotarget.12118

Alejandro Vazquez-Martin, Olga V. Anatskaya, Alessandro Giuliani, Jekaterina Erenpreisa, Sui Huang, Kristine Salmina, Inna Inashkina, Anda Huna, Nikolai N. Nikolsky,  and Alexander E. Vinogradov
75235-75260
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MDM2 and CDK4 amplifications are rare events in salivary duct carcinomas

MDM2 and CDK4 amplifications are rare events in salivary duct carcinomas

https://doi.org/10.18632/oncotarget.12127

Inga Grünewald, Marcel Trautmann, Alina Busch, Larissa Bauer, Sebastian Huss, Petra Schweinshaupt, Claudia Vollbrecht, Margarete Odenthal, Alexander Quaas, Reinhard Büttner, Moritz F. Meyer, Dirk Beutner, Karl-Bernd Hüttenbrink, Eva Wardelmann, Markus Stenner,  and Wolfgang Hartmann
75261-75272
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

IMPA2 polymorphisms and risk of ischemic stroke in a northwest Han Chinese population

IMPA2 polymorphisms and risk of ischemic stroke in a northwest Han Chinese population

https://doi.org/10.18632/oncotarget.12133

Qiaoya Ma, Ying Yang, Yuyan Na, Tianbo Jin, Yidong Xue, Yuting Shi, Chen Li,  and Wanggang Zhang
75273-75278
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

High-throughput proteomics integrated with gene microarray for discovery of colorectal cancer potential biomarkers

High-throughput proteomics integrated with gene microarray for discovery of colorectal cancer potential biomarkers

https://doi.org/10.18632/oncotarget.12143

Jiekai Yu, Xiaofen Li, Chenhan Zhong, Dan Li, Xiaohui Zhai, Wangxiong Hu, Cheng Guo, Ying Yuan,  and Shu Zheng
75279-75292
Abstract  |  PDF  |  HTML  |  Order a Reprint

Induction of anti-EGFR immune response with mimotopes identified from a phage display peptide library by panitumumab

Induction of anti-EGFR immune response with mimotopes identified from a phage display peptide library by panitumumab

https://doi.org/10.18632/oncotarget.12167

Aidong Wang, Ming Cui, Hong Qu, Jiabo Di, Zaozao Wang, Jiadi Xing, Fan Wu, Wei Wu, Xicheng Wang, Lin Shen, Beihai Jiang,  and Xiangqian Su
75293-75306
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Promoter methylation of PCDH10 by HOTAIR regulates the progression of gastrointestinal stromal tumors

Promoter methylation of PCDH10 by HOTAIR regulates the progression of gastrointestinal stromal tumors

https://doi.org/10.18632/oncotarget.12171

Na Keum Lee, Jung Hwa Lee, Won Kyu Kim, Seongju Yun, Young Hoon Youn, Chan Hyuk Park, Yun Young Choi, Hogeun Kim,  and Sang Kil Lee
75307-75318
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Tumor-specific gene therapy for pancreatic cancer using human neural stem cells encoding carboxylesterase

Tumor-specific gene therapy for pancreatic cancer using human neural stem cells encoding carboxylesterase

https://doi.org/10.18632/oncotarget.12173

Sung S. Choi, Kichul Yoon, Seon-A Choi, Seung-Bin Yoon, Seung U. Kim,  and Hong J. Lee
75319-75327
Abstract  |  PDF  |  HTML  |  Order a Reprint

MDM2 is a potential therapeutic target and prognostic factor for ovarian clear cell carcinomas with wild type TP53

MDM2 is a potential therapeutic target and prognostic factor for ovarian clear cell carcinomas with wild type TP53

https://doi.org/10.18632/oncotarget.12175

Chinami Makii, Katsutoshi Oda, Yuji Ikeda, Kenbun Sone, Kosei Hasegawa, Yuriko Uehara, Akira Nishijima, Kayo Asada, Takahiro Koso, Tomohiko Fukuda, Kanako Inaba, Shinya Oki, Hidenori Machino, Machiko Kojima, Tomoko Kashiyama, Mayuyo Mori-Uchino, Takahide Arimoto, Osamu Wada-Hiraike, Kei Kawana, Tetsu Yano, Keiichi Fujiwara, Hiroyuki Aburatani, Yutaka Osuga,  and Tomoyuki Fujii
75328-75338
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The transcriptional signature of human ovarian carcinoma macrophages is associated with extracellular matrix reorganization

The transcriptional signature of human ovarian carcinoma macrophages is associated with extracellular matrix reorganization

https://doi.org/10.18632/oncotarget.12180

Florian Finkernagel, Silke Reinartz, Sonja Lieber, Till Adhikary, Annika Wortmann, Nathalie Hoffmann, Tim Bieringer, Andrea Nist, Thorsten Stiewe, Julia M. Jansen, Uwe Wagner, Sabine Müller-Brüsselbach,  and Rolf Müller
75339-75352
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Concentration of circulating miRNA-containing particles in serum enhances miRNA detection and reflects CRC tissue-related deregulations

Concentration of circulating miRNA-containing particles in serum enhances miRNA detection and reflects CRC tissue-related deregulations

https://doi.org/10.18632/oncotarget.12205

Abdou ElSharawy, Christian Röder, Thomas Becker, Jens K. Habermann, Stefan Schreiber, Philip Rosenstiel,  and Holger Kalthoff
75353-75365
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Polarization of macrophages in the tumor microenvironment is influenced by EGFR signaling within colon cancer cells

Polarization of macrophages in the tumor microenvironment is influenced by EGFR signaling within colon cancer cells

https://doi.org/10.18632/oncotarget.12207

Weina Zhang, Lechuang Chen, Kai Ma, Yahui Zhao, Xianghe Liu, Yu Wang, Mei Liu, Shufang Liang, Hongxia Zhu,  and Ningzhi Xu
75366-75378
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Methylation of RAD51B, XRCC3 and other homologous recombination genes is associated with expression of immune checkpoints and an inflammatory signature in squamous cell carcinoma of the head and neck, lung and cervix

Methylation of RAD51B, XRCC3 and other homologous recombination genes is associated with expression of immune checkpoints and an inflammatory signature in squamous cell carcinoma of the head and neck, lung and cervix

https://doi.org/10.18632/oncotarget.12211

Damian T. Rieke, Sebastian Ochsenreither, Konrad Klinghammer, Tanguy Y. Seiwert, Frederick Klauschen, Inge Tinhofer,  and Ulrich Keilholz
75379-75393
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Fragile X mental retardation protein promotes astrocytoma proliferation via the MEK/ERK signaling pathway

Fragile X mental retardation protein promotes astrocytoma proliferation via the MEK/ERK signaling pathway

https://doi.org/10.18632/oncotarget.12215

Zhou Xing, Minling Zeng, Huixian Hu, Hui Zhang, Zhuofang Hao, Yuesheng Long, Shengqiang Chen, Hang Su, Zhongmin Yuan, Meng Xu,  and Jingqi Chen
75394-75406
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Indoleamine 2,3-dioxygenase regulates anti-tumor immunity in lung cancer by metabolic reprogramming of immune cells in the tumor microenvironment

Indoleamine 2,3-dioxygenase regulates anti-tumor immunity in lung cancer by metabolic reprogramming of immune cells in the tumor microenvironment

https://doi.org/10.18632/oncotarget.12249

Cara C. Schafer, Yong Wang, Kenneth P. Hough, Anandi Sawant, Stefan C. Grant, Victor J. Thannickal, Jaroslaw Zmijewski, Selvarangan Ponnazhagan,  and Jessy S. Deshane
75407-75424
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Targeting SALL4 by entinostat in lung cancer

Targeting SALL4 by entinostat in lung cancer

https://doi.org/10.18632/oncotarget.12251

Kol Jia Yong, Ailing Li, Wen-Bin Ou, Clarice Kit Yee Hong, Wenxiu Zhao, Fei Wang, Hiro Tatetsu, Benedict Yan, Lihua Qi, Jonathan A. Fletcher, Henry Yang, Ross Soo, Daniel G. Tenen,  and Li Chai
75425-75440
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

TACC3 overexpression in cholangiocarcinoma correlates with poor prognosis and is a potential anti-cancer molecular drug target for HDAC inhibitors

TACC3 overexpression in cholangiocarcinoma correlates with poor prognosis and is a potential anti-cancer molecular drug target for HDAC inhibitors

https://doi.org/10.18632/oncotarget.12254

Jun-chuang He, Wei Yao, Jian-ming Wang, Peter Schemmer, Yan Yang, Yan Liu, Ya-wei Qian, Wei-peng Qi, Jian Zhang, Qi Shen,  and Tao Yang
75441-75456
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The precision relationships between eight GWAS-identified genetic variants and breast cancer in a Chinese population

The precision relationships between eight GWAS-identified genetic variants and breast cancer in a Chinese population

https://doi.org/10.18632/oncotarget.12255

Yazhen Chen, Fangmeng Fu, Yuxiang Lin, Lin Qiu, Minjun Lu, Jiantang Zhang, Wei Qiu, Peidong Yang, Na Wu, Meng Huang,  and Chuan Wang
75457-75467
Abstract  |  PDF  |  HTML  |  Order a Reprint

Tyrosine kinase LYN is an oncotarget in human cervical cancer: A quantitative proteomic based study

Tyrosine kinase LYN is an oncotarget in human cervical cancer: A quantitative proteomic based study

https://doi.org/10.18632/oncotarget.12258

Shuaibin Liu, Xiaoming Hao, Xiaolan Ouyang, Xiaojing Dong, Yixuan Yang, Tinghe Yu, Jianguo Hu,  and Lina Hu
75468-75481
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Second-line ramucirumab therapy for advanced hepatocellular carcinoma (REACH): an East Asian and non-East Asian subgroup analysis

Second-line ramucirumab therapy for advanced hepatocellular carcinoma (REACH): an East Asian and non-East Asian subgroup analysis

https://doi.org/10.18632/oncotarget.12780

Joon Oh Park, Baek-Yeol Ryoo, Chia-Jui Yen, Masatoshi Kudo, Ling Yang, Paolo B. Abada, Rebecca Cheng, Mauro Orlando, Andrew X. Zhu,  and Takuji Okusaka
75482-75491
Abstract  |  PDF  |  HTML  |  Order a Reprint

Should all breast cancer patients with four or more positive lymph nodes who underwent modified radical mastectomy be treated with postoperative radiotherapy? A population-based study

Should all breast cancer patients with four or more positive lymph nodes who underwent modified radical mastectomy be treated with postoperative radiotherapy? A population-based study

https://doi.org/10.18632/oncotarget.12260

Haiyong Wang, Li Kong, Chenyue Zhang, Dawei Chen, Hui Zhu,  and Jinming Yu
75492-75502
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Epithelioid peritoneal mesothelioma: a hybrid phenotype within a mesenchymal-epithelial/epithelial-mesenchymal transition framework

Epithelioid peritoneal mesothelioma: a hybrid phenotype within a mesenchymal-epithelial/epithelial-mesenchymal transition framework

https://doi.org/10.18632/oncotarget.12262

Fabio Bozzi, Silvia Brich, Gian Paolo Dagrada, Tiziana Negri, Elena Conca, Barbara Cortelazzi, Antonino Belfiore, Federica Perrone, Ambra Vittoria Gualeni, Annunziata Gloghini, Antonello Cabras, Monica Brenca, Roberta Maestro, Nadia Zaffaroni, Paolo Casali, Rossella Bertulli, Marcello Deraco,  and Silvana Pilotti
75503-75517
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The impact of ERBB-family germline single nucleotide polymorphisms on survival response to adjuvant trastuzumab treatment in HER2-positive breast cancer

The impact of ERBB-family germline single nucleotide polymorphisms on survival response to adjuvant trastuzumab treatment in HER2-positive breast cancer

https://doi.org/10.18632/oncotarget.12782

Sinead Toomey, Stephen F. Madden, Simon J. Furney, Yue Fan, Mark McCormack, Carragh Stapleton, Mattia Cremona, Gianpiero L. Cavalleri, Malgorzata Milewska, Naomi Elster, Aoife Carr, Joanna Fay, Elaine W. Kay, Susan Kennedy, John Crown, William M. Gallagher, Bryan T. Hennessy,  and Alex J. Eustace
75518-75525
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Extrachromosomal HPV-16 LCR transcriptional activation by HDACi opposed by cellular differentiation and DNA integration

Extrachromosomal HPV-16 LCR transcriptional activation by HDACi opposed by cellular differentiation and DNA integration

https://doi.org/10.18632/oncotarget.12263

Ekaterina Dimitrova Bojilova, Christine Weyn, Marie-Hélène Antoine,  and Véronique Fontaine
75526-75538
Abstract  |  PDF  |  HTML  |  Order a Reprint

An inhibitor of cholesterol absorption displays anti-myeloma activity by targeting the JAK2-STAT3 signaling pathway

An inhibitor of cholesterol absorption displays anti-myeloma activity by targeting the JAK2-STAT3 signaling pathway

https://doi.org/10.18632/oncotarget.12265

Xin Xu, Kunkun Han, Jingyu Zhu, Hongwu Mao, Xu Lin, Zubin Zhang, Biyin Cao, Yuanying Zeng,  and Xinliang Mao
75539-75550
Abstract  |  PDF  |  HTML  |  Order a Reprint

PARP1 inhibitor olaparib (Lynparza) exerts synthetic lethal effect against ligase 4-deficient melanomas

PARP1 inhibitor olaparib (Lynparza) exerts synthetic lethal effect against ligase 4-deficient melanomas

https://doi.org/10.18632/oncotarget.12270

Małgorzata Czyż, Monika Toma, Anna Gajos-Michniewicz, Kinga Majchrzak, Grazyna Hoser, Janusz Szemraj, Margaret Nieborowska-Skorska, Phil Cheng, Daniel Gritsyuk, Mitchell Levesque, Reinhard Dummer, Tomasz Sliwinski,  and Tomasz Skorski
75551-75560
Abstract  |  PDF  |  HTML  |  Order a Reprint

SMAD7 polymorphisms and colorectal cancer risk: a meta-analysis of case-control studies

SMAD7 polymorphisms and colorectal cancer risk: a meta-analysis of case-control studies

https://doi.org/10.18632/oncotarget.12285

Yongsheng Huang, Wenting Wu, Meng Nie, Chuang Li,  and Lin Wang
75561-75570
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

IL-1 drives breast cancer growth and bone metastasis in vivo

IL-1 drives breast cancer growth and bone metastasis in vivo

https://doi.org/10.18632/oncotarget.12289

Ingunn Holen, Diane V. Lefley, Sheila E. Francis, Sarah Rennicks, Steven Bradbury, Robert E. Coleman,  and Penelope Ottewell
75571-75584
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

c-MYC drives histone demethylase PHF8 during neuroendocrine differentiation and in castration-resistant prostate cancer

c-MYC drives histone demethylase PHF8 during neuroendocrine differentiation and in castration-resistant prostate cancer

https://doi.org/10.18632/oncotarget.12310

Peterson Kariuki Maina, Peng Shao, Qi Liu, Ladan Fazli, Scott Tyler, Moman Nasir, Xuesen Dong,  and Hank Heng Qi
75585-75602
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Age and cellular context influence rectal prolapse formation in mice with caecal wall colorectal cancer xenografts

Age and cellular context influence rectal prolapse formation in mice with caecal wall colorectal cancer xenografts

https://doi.org/10.18632/oncotarget.12312

Joke Tommelein, Félix Gremonprez, Laurine Verset, Elly De Vlieghere, Glenn Wagemans, Christian Gespach, Tom Boterberg, Pieter Demetter, Wim Ceelen, Marc Bracke,  and Olivier De Wever
75603-75615
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Interconnections between apoptotic and autophagic pathways during thiopurine-induced toxicity in cancer cells: the role of reactive oxygen species

Interconnections between apoptotic and autophagic pathways during thiopurine-induced toxicity in cancer cells: the role of reactive oxygen species

https://doi.org/10.18632/oncotarget.12313

Wiem Chaabane,  and Malin Lindqvist Appell
75616-75634
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Fluorescence-guided surgery of a highly-metastatic variant of human triple-negative breast cancer targeted with a cancer-specific GFP adenovirus prevents recurrence

Fluorescence-guided surgery of a highly-metastatic variant of human triple-negative breast cancer targeted with a cancer-specific GFP adenovirus prevents recurrence

https://doi.org/10.18632/oncotarget.12314

Shuya Yano, Kiyoto Takehara, Shinji Miwa, Hiroyuki Kishimoto, Hiroshi Tazawa, Yasuo Urata, Shunsuke Kagawa, Michael Bouvet, Toshiyoshi Fujiwara,  and Robert M. Hoffman
75635-75647
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Whole-exome sequencing of muscle-invasive bladder cancer identifies recurrent copy number variation in IPO11 and prognostic significance of importin-11 overexpression on poor survival

Whole-exome sequencing of muscle-invasive bladder cancer identifies recurrent copy number variation in IPO11 and prognostic significance of importin-11 overexpression on poor survival

https://doi.org/10.18632/oncotarget.12315

Junjie Zhao, Weidong Xu, Minghui He, Zhensheng Zhang, Shuxiong Zeng, Chong Ma, Yinghao Sun,  and Chuanliang Xu
75648-75658
Abstract  |  PDF  |  HTML  |  Order a Reprint

Curcumin targets the TFEB-lysosome pathway for induction of autophagy

Curcumin targets the TFEB-lysosome pathway for induction of autophagy

https://doi.org/10.18632/oncotarget.12318

Jianbin Zhang, Jigang Wang, Jian Xu, Yuanqiang Lu, Jiukun Jiang, Liming Wang, Han-Ming Shen,  and Dajing Xia
75659-75671
Abstract  |  PDF  |  HTML  |  Order a Reprint

Epithelial cells captured from ductal carcinoma in situ reveal a gene expression signature associated with progression to invasive breast cancer

Epithelial cells captured from ductal carcinoma in situ reveal a gene expression signature associated with progression to invasive breast cancer

https://doi.org/10.18632/oncotarget.12352

Eliana Vanina Elias, Nadia Pereira de Castro, Paulo Henrique Baldan Pineda, Carolina Sens Abuázar, Cynthia Aparecida Bueno de Toledo Osorio, Mabel Gigliola Pinilla, Sabrina Daniela da Silva, Anamaria Aranha Camargo, Wilson Araujo Silva Jr, Elisa Napolitano e Ferreira, Helena Paula Brentani,  and Dirce Maria Carraro
75672-75684
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Differential effects of peptidoglycan on colorectal tumors and intestinal tissue post-pelvic radiotherapy

Differential effects of peptidoglycan on colorectal tumors and intestinal tissue post-pelvic radiotherapy

https://doi.org/10.18632/oncotarget.12353

Gen Li, Anqing Wu, Dandan Qi, Fengmei Cui, Yanan Zeng, Fang Xie, Hongya Wu, Yongping Gu, Qiu Chen,  and Xueguang Zhang
75685-75697
Abstract  |  PDF  |  HTML  |  Order a Reprint

SIRT1-mediated downregulation of p27Kip1 is essential for overcoming contact inhibition of Kaposi's sarcoma-associated herpesvirus transformed cells

SIRT1-mediated downregulation of p27Kip1 is essential for overcoming contact inhibition of Kaposi's sarcoma-associated herpesvirus transformed cells

https://doi.org/10.18632/oncotarget.12359

Meilan He, Hongfeng Yuan, Brandon Tan, Rosemary Bai, Heon Seok Kim, Sangsu Bae, Lu Che, Jin-Soo Kim,  and Shou-Jiang Gao
75698-75711
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Deregulation of the pRb-E2F4 axis alters epidermal homeostasis and favors tumor development

Deregulation of the pRb-E2F4 axis alters epidermal homeostasis and favors tumor development

https://doi.org/10.18632/oncotarget.12362

Clotilde Costa, Mirentxu Santos, Mónica Martínez-Fernández, Corina Lorz, Sara Lázaro,  and Jesús M. Paramio
75712-75728
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

FOXC1 identifies basal-like breast cancer in a hereditary breast cancer cohort

FOXC1 identifies basal-like breast cancer in a hereditary breast cancer cohort

https://doi.org/10.18632/oncotarget.12370

Jeff Johnson, Michael Choi, Farnaz Dadmanesh, Bingchen Han, Ying Qu, Yi Yu-Rice, Xiao Zhang, Sanjay Bagaria, Clive Taylor, Armando E. Giuliano, Farin Amersi,  and Xiaojiang Cui
75729-75738
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Prognostic significance of AMPK in human malignancies: A meta-analysis

Prognostic significance of AMPK in human malignancies: A meta-analysis

https://doi.org/10.18632/oncotarget.12405

Ji Cheng, Xiaoming Shuai, Jinbo Gao, Ming Cai, Guobin Wang,  and Kaixiong Tao
75739-75748
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Alpha fetoprotein antagonises benzyl isothiocyanate inhibition of the malignant behaviors of hepatocellular carcinoma cells

Alpha fetoprotein antagonises benzyl isothiocyanate inhibition of the malignant behaviors of hepatocellular carcinoma cells

https://doi.org/10.18632/oncotarget.12407

Mingyue Zhu, Wei Li, Junli Guo, Yan Lu, Xu Dong, Bo Lin, Yi Chen, Xueer Zhang,  and Mengsen Li
75749-75762
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Hypoxia-induced CCL28 promotes recruitment of regulatory T cells and tumor growth in liver cancer

Hypoxia-induced CCL28 promotes recruitment of regulatory T cells and tumor growth in liver cancer

https://doi.org/10.18632/oncotarget.12409

Li Ren, Yang Yu, Li Wang, Zhifeng Zhu, Rong Lu,  and Zhi Yao
75763-75773
Abstract  |  PDF  |  HTML  |  Order a Reprint

TNF induced cleavage of HSP90 by cathepsin D potentiates apoptotic cell death

TNF induced cleavage of HSP90 by cathepsin D potentiates apoptotic cell death

https://doi.org/10.18632/oncotarget.12411

Jürgen Fritsch, Ricarda Fickers, Jan Klawitter, Vinzenz Särchen, Philipp Zingler, Dieter Adam, Ottmar Janssen, Eberhard Krause,  and Stefan Schütze
75774-75789
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Lumbar puncture-administered resveratrol inhibits STAT3 activation, enhancing autophagy and apoptosis in orthotopic rat glioblastomas

Lumbar puncture-administered resveratrol inhibits STAT3 activation, enhancing autophagy and apoptosis in orthotopic rat glioblastomas

https://doi.org/10.18632/oncotarget.12414

Song Xue, Shu Xiao-Hong, Sha Lin, Bian Jie, Wang Li-Li, Gu Jia-Yao, Shi Shun, Li Pei-Nan, Wu Mo-Li, Wang Qian, Chen Xiao-Yan, Kong Qing-You, Zhang Peng, Li Hong,  and Liu Jia
75790-75799
Abstract  |  PDF  |  HTML  |  Order a Reprint

Secretory leukoprotease inhibitor is required for efficient quercetin-mediated suppression of TNFα secretion

Secretory leukoprotease inhibitor is required for efficient quercetin-mediated suppression of TNFα secretion

https://doi.org/10.18632/oncotarget.12415

Stefania De Santis, Dale Kunde, Grazia Serino, Vanessa Galleggiante, Maria Lucia Caruso, Mauro Mastronardi, Elisabetta Cavalcanti, Nicole Ranson, Aldo Pinto, Pietro Campiglia, Angelo Santino, Rajaraman Eri,  and Marcello Chieppa
75800-75809
Abstract  |  PDF  |  HTML  |  Order a Reprint

Exploring the interactions of the RAS family in the human protein network and their potential implications in RAS-directed therapies

Exploring the interactions of the RAS family in the human protein network and their potential implications in RAS-directed therapies

https://doi.org/10.18632/oncotarget.12416

Anibal Bueno, Ian Morilla, Diego Diez, Aurelio A. Moya-Garcia, José Lozano,  and Juan A.G. Ranea
75810-75826
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

PITX2 and PANCR DNA methylation predicts overall survival in patients with head and neck squamous cell carcinoma

PITX2 and PANCR DNA methylation predicts overall survival in patients with head and neck squamous cell carcinoma

https://doi.org/10.18632/oncotarget.12417

Verena Sailer, Emily Eva Holmes, Heidrun Gevensleben, Diane Goltz, Freya Dröge, Luka de Vos, Alina Franzen, Friederike Schröck, Friedrich Bootz, Glen Kristiansen, Andreas Schröck,  and Dimo Dietrich
75827-75838
Abstract  |  PDF  |  HTML  |  Order a Reprint

Concurrent MEK targeted therapy prevents MAPK pathway reactivation during BRAFV600E targeted inhibition in a novel syngeneic murine glioma model

Concurrent MEK targeted therapy prevents MAPK pathway reactivation during BRAFV600E targeted inhibition in a novel syngeneic murine glioma model

https://doi.org/10.18632/oncotarget.12419

Stefan Grossauer, Katharina Koeck, Nicole E. Murphy, Ian D. Meyers, Mathieu Daynac, Nathalene Truffaux, Albert Y. Truong, Theodore P. Nicolaides, Martin McMahon, Mitchel S. Berger, Joanna J. Phillips, David C. James,  and Claudia K. Petritsch
75839-75853
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Ran GTPase promotes cancer progression via Met receptor-mediated downstream signaling

Ran GTPase promotes cancer progression via Met receptor-mediated downstream signaling

https://doi.org/10.18632/oncotarget.12420

Hiu-Fung Yuen, Ka-Kui Chan, Angela Platt-Higgins, EL-Habib Dakir, Kyle B. Matchett, Yusuf Ahmed Haggag, Puthen V. Jithesh, Tanwir Habib, Ahmed Faheem, Fennell A. Dean, Richard Morgan, Philip S. Rudland,  and Mohamed El-Tanani
75854-75864
Abstract  |  PDF  |  HTML  |  Order a Reprint

MiR-608, pre-miR-124-1 and pre-miR26a-1 polymorphisms modify susceptibility and recurrence-free survival in surgically resected CRC individuals

MiR-608, pre-miR-124-1 and pre-miR26a-1 polymorphisms modify susceptibility and recurrence-free survival in surgically resected CRC individuals

https://doi.org/10.18632/oncotarget.12422

Hou-Qun Ying, Hong-Xin Peng, Bang-Shun He, Yu-Qin Pan, Feng Wang, Hui-Ling Sun, Xian Liu, Jie Chen, Kang Lin,  and Shu-Kui Wang
75865-75873
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A novel mechanism of action of HER2 targeted immunotherapy is explained by inhibition of NRF2 function in ovarian cancer cells

A novel mechanism of action of HER2 targeted immunotherapy is explained by inhibition of NRF2 function in ovarian cancer cells

https://doi.org/10.18632/oncotarget.12425

Hilal S. Khalil, Simon P. Langdon, Alexey Goltsov, Tero Soininen, David J. Harrison, James Bown,  and Yusuf Y. Deeni
75874-75901
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Human beta-defensin 3 contributes to the carcinogenesis of cervical cancer via activation of NF-κB signaling

Human beta-defensin 3 contributes to the carcinogenesis of cervical cancer via activation of NF-κB signaling

https://doi.org/10.18632/oncotarget.12426

Dan Xu, Bing Zhang, Chongbing Liao, Wei Zhang, Weijia Wang, Ying Chang,  and Yongping Shao
75902-75913
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Second-generation proteasome inhibitor carfilzomib sensitizes neuroblastoma cells to doxorubicin-induced apoptosis

Second-generation proteasome inhibitor carfilzomib sensitizes neuroblastoma cells to doxorubicin-induced apoptosis

https://doi.org/10.18632/oncotarget.12427

Shan Guan, Yanling Zhao, Jiaxiong Lu, Yang Yu, Wenjing Sun, Xinfang Mao, Zhenghu Chen, Xin Xu, Jessie Pan, Surong Sun,  and Jianhua Yang
75914-75925
Abstract  |  PDF  |  HTML  |  Order a Reprint

Delayed reendothelialization with rapamycin is rescued by the addition of nicorandil in balloon-injured rat carotid arteries

Delayed reendothelialization with rapamycin is rescued by the addition of nicorandil in balloon-injured rat carotid arteries

https://doi.org/10.18632/oncotarget.12444

Ying Qian Zhang, Feng Tian, Jin Song Chen, Yun Dai Chen, Ying Zhou, Bo Li, Qiang Ma,  and Ying Zhang
75926-75939
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Cancer cell-binding peptide fused Fc domain activates immune effector cells and blocks tumor growth

Cancer cell-binding peptide fused Fc domain activates immune effector cells and blocks tumor growth

https://doi.org/10.18632/oncotarget.12445

Anne Mobergslien, Qian Peng, Vlada Vasovic,  and Mouldy Sioud
75940-75953
Abstract  |  PDF  |  HTML  |  Order a Reprint

Doxycycline is an NF-κB inhibitor that induces apoptotic cell death in malignant T-cells

Doxycycline is an NF-κB inhibitor that induces apoptotic cell death in malignant T-cells

https://doi.org/10.18632/oncotarget.12488

Carolina V. Alexander-Savino, Matthew S. Hayden, Christopher Richardson, Jiyong Zhao,  and Brian Poligone
75954-75967
Abstract  |  PDF  |  HTML  |  Order a Reprint

Phosphoproteomics reveals ALK promote cell progress via RAS/ JNK pathway in neuroblastoma

Phosphoproteomics reveals ALK promote cell progress via RAS/ JNK pathway in neuroblastoma

https://doi.org/10.18632/oncotarget.12513

Kai Chen, Fan Lv, Guofeng Xu, Min Zhang, Yeming Wu,  and Zhixiang Wu
75968-75980
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

p53 increase mitochondrial copy number via up-regulation of mitochondrial transcription factor A in colorectal cancer

p53 increase mitochondrial copy number via up-regulation of mitochondrial transcription factor A in colorectal cancer

https://doi.org/10.18632/oncotarget.12514

Shilei Wen, Jinhang Gao, Linhao Zhang, Hongying Zhou, Dingzhi Fang,  and Shi Feng
75981-75995
Abstract  |  PDF  |  HTML  |  Order a Reprint

The prognostic value of DNA damage level in peripheral blood lymphocytes of chemotherapy-naïve patients with germ cell cancer

The prognostic value of DNA damage level in peripheral blood lymphocytes of chemotherapy-naïve patients with germ cell cancer

https://doi.org/10.18632/oncotarget.12515

Zuzana Sestakova, Katarina Kalavska, Lenka Hurbanova, Dana Jurkovicova, Jan Gursky, Michal Chovanec, Daniela Svetlovska, Vera Miskovska, Jana Obertova, Patrik Palacka, Katarina Rejlekova, Zuzana Sycova-Mila, Silvia Cingelova, Stanislav Spanik, Jozef Mardiak, Miroslav Chovanec,  and Michal Mego
75996-76005
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Autocrine interleukin-23 promotes self-renewal of CD133+ ovarian cancer stem-like cells

Autocrine interleukin-23 promotes self-renewal of CD133+ ovarian cancer stem-like cells

https://doi.org/10.18632/oncotarget.12579

Dan Wang, Tong Xiang, Zhongquan Zhao, Kailong Lin, Pin Yin, Lupin Jiang, Zhiqing Liang,  and Bo Zhu
76006-76020
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Common polymorphisms in CD44 gene and susceptibility to cancer: a systematic review and meta-analysis of 45 studies

Common polymorphisms in CD44 gene and susceptibility to cancer: a systematic review and meta-analysis of 45 studies

https://doi.org/10.18632/oncotarget.12580

Meng Zhang, Yangyang Wang, Tingting Fang, Yangke Cai, Yue Xu, Cunye Yan, Li Zhang,  and Chaozhao Liang
76021-76035
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

SOX17 is a tumor suppressor in endometrial cancer

SOX17 is a tumor suppressor in endometrial cancer

https://doi.org/10.18632/oncotarget.12582

Yongli Zhang, Wei Bao, Kai Wang, Wen Lu, Huihui Wang, Huan Tong,  and Xiaoping Wan
76036-76046
Abstract  |  PDF  |  HTML  |  Order a Reprint

Loss of UHRF2 expression is associated with human neoplasia, promoter hypermethylation, decreased 5-hydroxymethylcytosine, and high proliferative activity

Loss of UHRF2 expression is associated with human neoplasia, promoter hypermethylation, decreased 5-hydroxymethylcytosine, and high proliferative activity

https://doi.org/10.18632/oncotarget.12583

Huarui Lu, Sweta Bhoopatiraju, Hongbo Wang, Nolan P. Schmitz, Xiaohong Wang, Matthew J. Freeman, Colleen L. Forster, Michael R. Verneris, Michael A. Linden,  and Timothy C. Hallstrom
76047-76061
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Hedgehog and TGFβ signaling converge on Gli2 to control bony invasion and bone destruction in oral squamous cell carcinoma

Hedgehog and TGFβ signaling converge on Gli2 to control bony invasion and bone destruction in oral squamous cell carcinoma

https://doi.org/10.18632/oncotarget.12584

Shellese A. Cannonier, Cara B. Gonzales, Kim Ely, Scott A. Guelcher,  and Julie A. Sterling
76062-76075
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Berberine inhibits EGFR signaling and enhances the antitumor effects of EGFR inhibitors in gastric cancer

Berberine inhibits EGFR signaling and enhances the antitumor effects of EGFR inhibitors in gastric cancer

https://doi.org/10.18632/oncotarget.12589

Junxiong Wang, Shuo Yang, Xiqiang Cai, Jiaqiang Dong, Zhangqian Chen, Rui Wang, Song Zhang, Haichao Cao, Di Lu, Tong Jin, Yongzhan Nie, Jianyu Hao,  and Daiming Fan
76076-76086
Abstract  |  PDF  |  HTML  |  Order a Reprint

Interleukin-1 blockade overcomes erlotinib resistance in head and neck squamous cell carcinoma

Interleukin-1 blockade overcomes erlotinib resistance in head and neck squamous cell carcinoma

https://doi.org/10.18632/oncotarget.12590

Aditya Stanam, Katherine N. Gibson-Corley, Laurie Love-Homan, Nnamdi Ihejirika,  and Andrean L. Simons
76087-76100
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Genetic variants in PTPRD and risk of gestational diabetes mellitus

Genetic variants in PTPRD and risk of gestational diabetes mellitus

https://doi.org/10.18632/oncotarget.12599

Ting Chen, Juan Xu, Guangquan Liu, Heng Liu, Minjian Chen, Yufeng Qin, Wei Wu, Yankai Xia, Chenbo Ji, Xirong Guo, Juan Wen,  and Xinru Wang
76101-76107
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Overexpression of ZNF703 facilitates tumorigenesis and predicts unfavorable prognosis in patients with cholangiocarcinoma

Overexpression of ZNF703 facilitates tumorigenesis and predicts unfavorable prognosis in patients with cholangiocarcinoma

https://doi.org/10.18632/oncotarget.12627

Keyu Li, Jiabei Wang, Jihua Han, Yaliang Lan, Changming Xie, Shangha Pan,  and Lianxin Liu
76108-76117
Abstract  |  PDF  |  HTML  |  Order a Reprint

Safety and efficacy of vismodegib in patients aged ≥65 years with advanced basal cell carcinoma

Safety and efficacy of vismodegib in patients aged ≥65 years with advanced basal cell carcinoma

https://doi.org/10.18632/oncotarget.12660

Anne Lynn S. Chang, Karl D. Lewis, Sarah T. Arron, Michael R. Migden, James A. Solomon, Simon Yoo, Bann-Mo Day, Edward F. McKenna,  and Aleksandar Sekulic
76118-76124
Abstract  |  PDF  |  HTML  |  Order a Reprint

Epithelial-to-mesenchymal transition leads to disease-stage differences in circulating tumor cell detection and metastasis in pre-clinical models of prostate cancer

Epithelial-to-mesenchymal transition leads to disease-stage differences in circulating tumor cell detection and metastasis in pre-clinical models of prostate cancer

https://doi.org/10.18632/oncotarget.12682

Lori E. Lowes, David Goodale, Ying Xia, Carl Postenka, Matthew M. Piaseczny, Freeman Paczkowski,  and Alison L. Allan
76125-76139
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Altered RECQL5 expression in urothelial bladder carcinoma increases cellular proliferation and makes RECQL5 helicase activity a novel target for chemotherapy

Altered RECQL5 expression in urothelial bladder carcinoma increases cellular proliferation and makes RECQL5 helicase activity a novel target for chemotherapy

https://doi.org/10.18632/oncotarget.12683

Karl Patterson, Lovleen Arya, Sarah Bottomley, Susan Morgan, Angela Cox, James Catto,  and Helen E. Bryant
76140-76150
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Expression of CK19 is an independent predictor of negative outcome for patients with squamous cell carcinoma of the tongue

Expression of CK19 is an independent predictor of negative outcome for patients with squamous cell carcinoma of the tongue

https://doi.org/10.18632/oncotarget.12691

Jutta Ernst, Kristian Ikenberg, Barbara Apel, Desiree M. Schumann, Gerhard Huber, Gabriela Studer, Tamara Rordorf, Oliver Riesterer, Matthias Rössle, Dimitri Korol,  and Marius G. Bredell
76151-76158
Abstract  |  PDF  |  HTML  |  Order a Reprint

Visualization of early prostatic adenocarcinoma as a stem cell disease

Visualization of early prostatic adenocarcinoma as a stem cell disease

https://doi.org/10.18632/oncotarget.12709

Maggie Y. Jiang, Tammy L. Lee, Su-Shin Hao, Sepi Mahooti, Stephen M. Baird, Daniel J. Donoghue,  and Martin Haas
76159-76168
Abstract  |  PDF  |  HTML  |  Order a Reprint

Microarray analysis on the lncRNA expression profile in male hepatocelluar carcinoma patients with chronic hepatitis B virus infection

Microarray analysis on the lncRNA expression profile in male hepatocelluar carcinoma patients with chronic hepatitis B virus infection

https://doi.org/10.18632/oncotarget.12732

Jianjun Niu, Yong Lin, Pingguo Liu, Yiwen Yu, Chenghao Su,  and Xiaomin Wang
76169-76180
Abstract  |  PDF  |  HTML  |  Order a Reprint

Combination effect of therapies targeting the PI3K- and AR-signaling pathways in prostate cancer

Combination effect of therapies targeting the PI3K- and AR-signaling pathways in prostate cancer

https://doi.org/10.18632/oncotarget.12771

Shalini Singh Yadav, Jinyi Li, Jennifer A. Stockert, James O’Connor, Bryan Herzog, Cordelia Elaiho, Matthew D. Galsky, Ashutosh Kumar Tewari,  and Kamlesh Kumar Yadav
76181-76196
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Highly aligned stromal collagen is a negative prognostic factor following pancreatic ductal adenocarcinoma resection

Highly aligned stromal collagen is a negative prognostic factor following pancreatic ductal adenocarcinoma resection

https://doi.org/10.18632/oncotarget.12772

Cole R. Drifka, Agnes G. Loeffler, Kara Mathewson, Adib Keikhosravi, Jens C. Eickhoff, Yuming Liu, Sharon M. Weber, W. John Kao,  and Kevin W. Eliceiri
76197-76213
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Prognostic value of vascular mimicry in patients with urothelial carcinoma of the bladder after radical cystectomy

Prognostic value of vascular mimicry in patients with urothelial carcinoma of the bladder after radical cystectomy

https://doi.org/10.18632/oncotarget.12775

Lin Zhou, Yuan Chang, Le Xu, Son Tung Nguyen Hoang, Zheng Liu, Qiang Fu, Zongming Lin,  and Jiejie Xu
76214-76223
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Focal adhesion molecule Kindlin-1 mediates activation of TGF-β signaling by interacting with TGF-βRI, SARA and Smad3 in colorectal cancer cells

Focal adhesion molecule Kindlin-1 mediates activation of TGF-β signaling by interacting with TGF-βRI, SARA and Smad3 in colorectal cancer cells

https://doi.org/10.18632/oncotarget.12779

Jinfeng Kong, Juan Du, Yunling Wang, Mingzi Yang, Jianchao Gao, Xiaofan Wei, Weigang Fang, Jun Zhan,  and Hongquan Zhang
76224-76237
Abstract  |  PDF  |  HTML  |  Order a Reprint

Resistance of glioma cells to nutrient-deprived microenvironment can be enhanced by CD133-mediated autophagy

Resistance of glioma cells to nutrient-deprived microenvironment can be enhanced by CD133-mediated autophagy

https://doi.org/10.18632/oncotarget.12803

Haojie Sun, Mingzhi Zhang, Kai Cheng, Peng Li, Shuo Han, Ruizhi Li, Ming Su, Wotan Zeng, Jinwen Liu, Jinhai Guo, Yinan Liu, Xiaoyan Zhang, Qihua He,  and Li Shen
76238-76249
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Serum exosomal miR-4772-3p is a predictor of tumor recurrence in stage II and III colon cancer

Serum exosomal miR-4772-3p is a predictor of tumor recurrence in stage II and III colon cancer

https://doi.org/10.18632/oncotarget.12841

Chang Liu, Cathy Eng, Jianjun Shen, Yue Lu, Yoko Takata, Amir Mehdizadeh, George J. Chang, Miguel A. Rodriguez-Bigas, Yanan Li, Ping Chang, Yixiang Mao, Manal M. Hassan, Fangyu Wang,  and Donghui Li
76250-76260
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A new classification of lymph node metastases according to the lymph node stations for predicting prognosis in surgical patients with esophageal squamous cell carcinoma

A new classification of lymph node metastases according to the lymph node stations for predicting prognosis in surgical patients with esophageal squamous cell carcinoma

https://doi.org/10.18632/oncotarget.12842

Zheng Lin, Weilin Chen, Yuanmei Chen, Xiane Peng, Kunshou Zhu, Yimin Lin, Qiaokuang Lin,  and Zhijian Hu
76261-76273
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Clinical Research Papers

Clinical relevance of circulating mucosal-associated invariant T cell levels and their anti-cancer activity in patients with mucosal-associated cancer

Clinical relevance of circulating mucosal-associated invariant T cell levels and their anti-cancer activity in patients with mucosal-associated cancer

https://doi.org/10.18632/oncotarget.11187

Eun Jeong Won, Jae Kyun Ju, Young-Nan Cho, Hye-Mi Jin, Ki-Jeong Park, Tae-Jong Kim, Yong-Soo Kwon, Hae Jin Kee, Jung-Chul Kim, Seung-Jung Kee,  and Yong-Wook Park
76274-76290
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Clinical characteristics and prognostic factors of brain central neurocytoma

Clinical characteristics and prognostic factors of brain central neurocytoma

https://doi.org/10.18632/oncotarget.11228

Yaqi Song, Xinle Kang, Gang Cao, Yongqiang Li, Xilei Zhou, Yusuo Tong,  and Wanwei Wang
76291-76297
Abstract  |  PDF  |  HTML  |  Order a Reprint

Efficacy of preoperative chemotherapy regimens in patients with initially unresectable locally advanced gastric adenocarcinoma: capecitabine and oxaliplatin (XELOX) or with epirubicin (EOX)

Efficacy of preoperative chemotherapy regimens in patients with initially unresectable locally advanced gastric adenocarcinoma: capecitabine and oxaliplatin (XELOX) or with epirubicin (EOX)

https://doi.org/10.18632/oncotarget.11818

Yan Wang, Rong-yuan Zhuang, Yi-yi Yu, Shan Yu, Jun Hou, Yuan Ji, Yi-hong Sun, Kun-tang Shen, Zhen-bin Shen, Feng-lin Liu, Nai-qing Zhao,  and Tian-shu Liu
76298-76307
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Laparoscopic sleeve gastrectomy versus Roux-en-Y gastric bypass for morbid obesity: a 1:1 matched cohort study in a Chinese population

Laparoscopic sleeve gastrectomy versus Roux-en-Y gastric bypass for morbid obesity: a 1:1 matched cohort study in a Chinese population

https://doi.org/10.18632/oncotarget.12536

Xiao Du, Si-qin Zhang, Hong-xu Zhou, Xue Li, Xiao-juan Zhang, Zong-guang Zhou,  and Zhong Cheng
76308-76315
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Comparison of efficacy in adjuvant chemotherapy regimens in patients with radically resected gastric cancer: a propensity-matched analysis

Comparison of efficacy in adjuvant chemotherapy regimens in patients with radically resected gastric cancer: a propensity-matched analysis

https://doi.org/10.18632/oncotarget.11783

RenCui Quan, JiaXing Huang, HongTao Chen, YiFeng Liao, WeiZe Lv, Nan Chen, JianJun Liu, HongYu Zhang,  and DaZhi Xu
76316-76326
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Reviews

TMPRSS4 as an emerging potential poor prognostic factor for solid tumors: A systematic review and meta-analysis

TMPRSS4 as an emerging potential poor prognostic factor for solid tumors: A systematic review and meta-analysis

https://doi.org/10.18632/oncotarget.10153

Ping Zeng, Peng Zhang, Li-Na Zhou, Min Tang, Yi-Xin Shen, Jun Jin, Ya-Qun Zhu,  and Min-Bin Chen
76327-76336
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Targeting signal transduction pathways of cancer stem cells for therapeutic opportunities of metastasis

Targeting signal transduction pathways of cancer stem cells for therapeutic opportunities of metastasis

https://doi.org/10.18632/oncotarget.10942

Waqas Iqbal, Saleh Alkarim, Ahmed AlHejin, Hasan Mukhtar,  and Kulvinder S. Saini
76337-76353
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