Oncotarget

Vol 7, No 43

October 25, 2016

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About The Cover

The cover for issue 43 of Oncotarget features Figure 2, 'Linkage disequilibrium structure and regional association map of TGFBR2 with risk of clear cell ovarian cancer' from Hampras, et al

Table of Contents

Priority Research Papers

Assessment of variation in immunosuppressive pathway genes reveals TGFBR2 to be associated with risk of clear cell ovarian cancer

Assessment of variation in immunosuppressive pathway genes reveals TGFBR2 to be associated with risk of clear cell ovarian cancer

https://doi.org/10.18632/oncotarget.10215

Shalaka S. Hampras, Lara E. Sucheston-Campbell, Rikki Cannioto, Jenny Chang-Claude, Francesmary Modugno, Thilo Dörk, Peter Hillemanns, Leah Preus, Keith L. Knutson, Paul K. Wallace, Chi-Chen Hong, Grace Friel, Warren Davis, Mary Nesline, Celeste L. Pearce, Linda E. Kelemen, Marc T. Goodman, Elisa V. Bandera, Kathryn L. Terry, Nils Schoof, Kevin H. Eng, Alyssa Clay, Prashant K. Singh, Janine M. Joseph, Katja K.H. Aben, Hoda Anton-Culver, Natalia Antonenkova, Helen Baker, Yukie Bean, Matthias W. Beckmann, Maria Bisogna, Line Bjorge, Natalia Bogdanova, Louise A. Brinton, Angela Brooks-Wilson, Fiona Bruinsma, Ralf Butzow, Ian G. Campbell, Karen Carty, Linda S. Cook, Daniel W. Cramer, Cezary Cybulski, Agnieszka Dansonka-Mieszkowska, Joe Dennis, Evelyn Despierre, Ed Dicks, Jennifer A. Doherty, Andreas du Bois, Matthias Dürst, Doug Easton, Diana Eccles, Robert P. Edwards, Arif B. Ekici, Peter A. Fasching, Brooke L. Fridley, Yu-Tang Gao, Aleksandra Gentry-Maharaj, Graham G. Giles, Rosalind Glasspool, Jacek Gronwald, Patricia Harrington, Philipp Harter, Hanis Nazihah Hasmad, Alexander Hein, Florian Heitz, Michelle A.T. Hildebrandt, Claus Hogdall, Estrid Hogdall, Satoyo Hosono, Edwin S. Iversen, Anna Jakubowska, Allan Jensen, Bu-Tian Ji, Beth Y. Karlan, Melissa Kellar, Joseph L. Kelley, Lambertus A. Kiemeney, Rüdiger Klapdor, Nonna Kolomeyevskaya, Camilla Krakstad, Susanne K. Kjaer, Bridget Kruszka, Jolanta Kupryjanczyk, Diether Lambrechts, Sandrina Lambrechts, Nhu D. Le, Alice W. Lee, Shashikant Lele, Arto Leminen, Jenny Lester, Douglas A. Levine, Dong Liang, Jolanta Lissowska, Song Liu, Karen Lu, Jan Lubinski, Lene Lundvall, Leon F.A.G. Massuger, Keitaro Matsuo, Valeria McGuire, John R. McLaughlin, Ian McNeish, Usha Menon, Joanna Moes-Sosnowska, Steven A. Narod, Lotte Nedergaard, Heli Nevalinna, Stefan Nickels, Lotte Nedergaard, Heli Nevanlinna, Stefan Nickels, Sara H. Olson, Irene Orlow, Rachel Palmieri Weber, James Paul, Tanja Pejovic, Liisa M. Pelttari, Barbara Perkins, Jenny Permuth-Wey, Malcolm C. Pike, Joanna Plisiecka-Halasa, Elizabeth M. Poole, Harvey A. Risch, Mary Anne Rossing, Joseph H. Rothstein, Anja Rudolph, Ingo B. Runnebaum, Iwona K. Rzepecka, Helga B. Salvesen, Eva Schernhammer, Kristina Schmitt, Ira Schwaab, Xiao-Ou Shu, Yurii B. Shvetsov, Nadeem Siddiqui, Weiva Sieh, Honglin Song, Melissa C. Southey, Ingvild L. Tangen, Soo-Hwang Teo, Pamela J. Thompson, Agnieszka Timorek, Ya-Yu Tsai, Shelley S. Tworoger, Jonathan Tyrer, Anna M. van Altena, Ignace Vergote, Robert A. Vierkant, Christine Walsh, Shan Wang-Gohrke, Nicolas Wentzensen, Alice S. Whittemore, Kristine G. Wicklund, Lynne R. Wilkens, Anna H. Wu, Xifeng Wu, Yin-Ling Woo, Hannah Yang, Wei Zheng, Argyrios Ziogas, Simon A. Gayther, Susan J. Ramus, Thomas A. Sellers, Joellen M. Schildkraut, Catherine M. Phelan, Andrew Berchuck, Georgia Chenevix-Trench, Julie M. Cunningham, Paul P. Pharoah, Roberta B. Ness, Kunle Odunsi, Ellen L. Goode,  and Kirsten B. Moysich
69097-69110
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Defining the transcriptional and biological response to CDK4/6 inhibition in relation to ER+/HER2- breast cancer

Defining the transcriptional and biological response to CDK4/6 inhibition in relation to ER+/HER2- breast cancer

https://doi.org/10.18632/oncotarget.11588

Erik S. Knudsen,  and Agnieszka K. Witkiewicz
69111-69123
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Dnmt3a deletion cooperates with the Flt3/ITD mutation to drive leukemogenesis in a murine model

Dnmt3a deletion cooperates with the Flt3/ITD mutation to drive leukemogenesis in a murine model

https://doi.org/10.18632/oncotarget.11986

Jennifer L. Poitras, Diane Heiser, Li Li, Bao Nguyen, Kozo Nagai, Amy S. Duffield, Christopher Gamper,  and Donald Small
69124-69135
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Native and bone marrow-derived cell mosaicism in gastric carcinoma in H. pylori-infected p27-deficient mice

Native and bone marrow-derived cell mosaicism in gastric carcinoma in H. pylori-infected p27-deficient mice

https://doi.org/10.18632/oncotarget.12049

Songhua Zhang, Woojin Kim, Tu T. Pham, Arlin B. Rogers, Jean Marie Houghton,  and Steven F. Moss
69136-69148
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Targeting the ERK pathway for the treatment of Cushing’s disease

Targeting the ERK pathway for the treatment of Cushing’s disease

https://doi.org/10.18632/oncotarget.12381

Dongyun Zhang, Marvin Bergsneider, Marilene B. Wang,  and Anthony P. Heaney
69149-69158
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RGS6 is an essential tumor suppressor that prevents bladder carcinogenesis by promoting p53 activation and DNMT1 downregulation

RGS6 is an essential tumor suppressor that prevents bladder carcinogenesis by promoting p53 activation and DNMT1 downregulation

https://doi.org/10.18632/oncotarget.12473

Jianqi Yang, Lance T. Platt, Biswanath Maity, Katelin E. Ahlers, Zili Luo, Zhibo Lin, Bandana Chakravarti, Stella-Rita Ibeawuchi, Ryan W. Askeland, Jolanta Bondaruk, Bogdan A. Czerniak,  and Rory A. Fisher
69159-69172
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IKK/NF-κB signaling contributes to glioblastoma stem cell maintenance

IKK/NF-κB signaling contributes to glioblastoma stem cell maintenance

https://doi.org/10.18632/oncotarget.12507

Amanda L. Rinkenbaugh, Patricia C. Cogswell, Barbara Calamini, Denise E. Dunn, Anders I. Persson, William A. Weiss, Donald C. Lo,  and Albert S. Baldwin
69173-69187
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Research Papers: Gerotarget (Focus on Aging)

Mutational load and mutational patterns in relation to age in head and neck cancer

Mutational load and mutational patterns in relation to age in head and neck cancer

https://doi.org/10.18632/oncotarget.11312

Stefano Meucci, Ulrich Keilholz, Ingeborg Tinhofer,  and Oliva A. Ebner
69188-69199
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Reduced bone resorption by intake of dietary vitamin D and K from tailor-made Atlantic salmon: a randomized intervention trial

Reduced bone resorption by intake of dietary vitamin D and K from tailor-made Atlantic salmon: a randomized intervention trial

https://doi.org/10.18632/oncotarget.10171

Ingvild Eide Graff, Jannike Øyen, Marian Kjellevold, Livar Frøyland, Clara Gram Gjesdal, Bjørg Almås, Grethe Rosenlund,  and Øyvind Lie
69200-69215
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The effect of the severity of obstructive sleep apnea syndrome on telomere length

The effect of the severity of obstructive sleep apnea syndrome on telomere length

https://doi.org/10.18632/oncotarget.12293

Priscila Farias Tempaku, Diego Robles Mazzotti, Camila Hirotsu, Monica Levy Andersen, Gabriela Xavier, Pawan Kumar Maurya, Lucas Bortolotto Rizzo, Elisa Brietzke, Sintia Iole Belangero, Lia Bittencourt,  and Sergio Tufik
69216-69224
Abstract  |  PDF  |  HTML  |  Order a Reprint

INPP5D rs35349669 polymorphism with late-onset Alzheimer’s disease: A replication study and meta-analysis

INPP5D rs35349669 polymorphism with late-onset Alzheimer’s disease: A replication study and meta-analysis

https://doi.org/10.18632/oncotarget.12648

Hua Jing, Jun-Xia Zhu, Hui-Fu Wang, Wei Zhang, Zhan-Jie Zheng, Ling-Li Kong, Chen-Chen Tan, Zi-Xuan Wang, Lin Tan,  and Lan Tan
69225-69230
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Research Papers: Pathology

Fibroblast growth factor 23 dysregulates late sodium current and calcium homeostasis with enhanced arrhythmogenesis in pulmonary vein cardiomyocytes

Fibroblast growth factor 23 dysregulates late sodium current and calcium homeostasis with enhanced arrhythmogenesis in pulmonary vein cardiomyocytes

https://doi.org/10.18632/oncotarget.12470

Shih-Yu Huang, Yao-Chang Chen, Yu-Hsun Kao, Ming-Hsiung Hsieh, Yung-Kuo Lin, Cheng-Chih Chung, Ting-I Lee, Wen-Chin Tsai, Shih-Ann Chen,  and Yi-Jen Chen
69231-69242
Abstract  |  PDF  |  HTML  |  Order a Reprint

Nitric oxide, PKC-ε, and connexin43 are crucial for ischemic preconditioning-induced chemical gap junction uncoupling

Nitric oxide, PKC-ε, and connexin43 are crucial for ischemic preconditioning-induced chemical gap junction uncoupling

https://doi.org/10.18632/oncotarget.12087

Bing Rong, Fei Xie, Tao Sun, Li Hao, Ming-Jie Lin,  and Jing-Quan Zhong
69243-69255
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Delineation of the central melanocortin circuitry controlling the kidneys by a virally mediated transsynaptic tracing study in transgenic mouse model

Delineation of the central melanocortin circuitry controlling the kidneys by a virally mediated transsynaptic tracing study in transgenic mouse model

https://doi.org/10.18632/oncotarget.11956

Tao Tao Liu, Bao Wen Liu, Zhi Gang He, Li Feng, San Guang Liu,  and Hong Bing Xiang
69256-69266
Abstract  |  PDF  |  HTML  |  Order a Reprint

Frequent somatic TERT promoter mutations and CTNNB1 mutations in hepatocellular carcinoma

Frequent somatic TERT promoter mutations and CTNNB1 mutations in hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.12121

Seung Eun Lee, Seong-Hwan Chang, Wook Youn Kim, So Dug Lim, Wan Seop Kim, Tea Sook Hwang,  and Hye Seung Han
69267-69275
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Signaling through hepatocyte vasopressin receptor 1 protects mouse liver from ischemia-reperfusion injury

Signaling through hepatocyte vasopressin receptor 1 protects mouse liver from ischemia-reperfusion injury

https://doi.org/10.18632/oncotarget.12472

Xiqiang Liu, Gaojian Luo, Jingbo Jiang, Tonghui Ma, Xiaozhu Lin, Liping Jiang, Jilin Cheng,  and Ran Tao
69276-69290
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Pharmacological targeting of BET proteins inhibits renal fibroblast activation and alleviates renal fibrosis

Pharmacological targeting of BET proteins inhibits renal fibroblast activation and alleviates renal fibrosis

https://doi.org/10.18632/oncotarget.12498

Chongxiang Xiong, Monica V. Masucci, Xiaoxu Zhou, Na Liu, Xiujuan Zang, Evelyn Tolbert, Ting C. Zhao,  and Shougang Zhuang
69291-69308
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Overexpressed cyclophilin B suppresses aldosterone-induced proximal tubular cell injury both in vitro and in vivo

Overexpressed cyclophilin B suppresses aldosterone-induced proximal tubular cell injury both in vitro and in vivo

https://doi.org/10.18632/oncotarget.12503

Bin Wang, Lilu Lin, Haidong Wang, Honglei Guo, Yong Gu,  and Wei Ding
69309-69320
Abstract  |  PDF  |  HTML  |  Order a Reprint

SIRT3 is attenuated in systemic sclerosis skin and lungs, and its pharmacologic activation mitigates organ fibrosis

SIRT3 is attenuated in systemic sclerosis skin and lungs, and its pharmacologic activation mitigates organ fibrosis

https://doi.org/10.18632/oncotarget.12504

Kaname Akamata, Jun Wei, Mitra Bhattacharyya, Paul Cheresh, Michael Y. Bonner, Jack L. Arbiser, Kirtee Raparia, Mahesh P. Gupta, David W. Kamp,  and John Varga
69321-69336
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Movement deficits and neuronal loss in basal ganglia in TRPC1 deficient mice

Movement deficits and neuronal loss in basal ganglia in TRPC1 deficient mice

https://doi.org/10.18632/oncotarget.12567

Kaiwu He, Fei Qi, Chunni Guo, Shuqin Zhan, Hua Xu, Jianjun Liu,  and Xifei Yang
69337-69346
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Research Papers: Immunology

Neuroprotective effects of CD4+CD25+Foxp3+ regulatory T cells in a 3xTg-AD Alzheimer’s disease model

Neuroprotective effects of CD4+CD25+Foxp3+ regulatory T cells in a 3xTg-AD Alzheimer’s disease model

https://doi.org/10.18632/oncotarget.12469

Hyunjung Baek, Minsook Ye, Geun-Hyung Kang, Chanju Lee, Gihyun Lee, Da Bin Choi, Jaehoon Jung, Hyunseong Kim, Seonhwa Lee, Jin Su Kim, Hyun-ju Lee, Insop Shim, Jun-Ho Lee,  and Hyunsu Bae
69347-69357
Abstract  |  PDF  |  HTML  |  Order a Reprint

Nucleoside 5’-O-monophosphorothioates as modulators of the P2Y14 receptor and mast cell degranulation

Nucleoside 5’-O-monophosphorothioates as modulators of the P2Y14 receptor and mast cell degranulation

https://doi.org/10.18632/oncotarget.12541

Edyta Gendaszewska-Darmach, Edyta Węgłowska, Aurelia Walczak-Drzewiecka,  and Kaja Karaś
69358-69370
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Blocking TCR restimulation induced necroptosis in adoptively transferred T cells improves tumor control

Blocking TCR restimulation induced necroptosis in adoptively transferred T cells improves tumor control

https://doi.org/10.18632/oncotarget.12674

Pravin Kesarwani, Paramita Chakraborty, Radhika Gudi, Shilpak Chatterjee, Gina Scurti, Kyle Toth, Patt Simms, Mahvash Husain, Kent Armeson, Shahid Husain, Elizabeth Garrett-Mayer, Chethamarakshan Vasu, Michael I. Nishimura,  and Shikhar Mehrotra
69371-69383
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Research Papers

Functional genetic variant in the Kozak sequence of WW domain-containing oxidoreductase (WWOX) gene is associated with oral cancer risk

Functional genetic variant in the Kozak sequence of WW domain-containing oxidoreductase (WWOX) gene is associated with oral cancer risk

https://doi.org/10.18632/oncotarget.12082

Hsin-Lin Cheng, Yu-Fan Liu, Chun-Wen Su, Shih-Chi Su, Mu-Kuan Chen, Shun-Fa Yang,  and Chiao-Wen Lin
69384-69396
Abstract  |  PDF  |  HTML  |  Order a Reprint

Implication of NPM1 phosphorylation and preclinical evaluation of the nucleoprotein antagonist N6L in prostate cancer

Implication of NPM1 phosphorylation and preclinical evaluation of the nucleoprotein antagonist N6L in prostate cancer

https://doi.org/10.18632/oncotarget.8043

Damien Destouches, Maha Sader, Stéphane Terry, Charles Marchand, Pascale Maillé, Pascale Soyeux, Gilles Carpentier, Fannie Semprez, Jocelyn Céraline, Yves Allory, José Courty, Alexandre De La Taille,  and Francis Vacherot
69397-69411
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Imatinib dose escalation versus sunitinib as a second line treatment in KIT exon 11 mutated GIST: a retrospective analysis

Imatinib dose escalation versus sunitinib as a second line treatment in KIT exon 11 mutated GIST: a retrospective analysis

https://doi.org/10.18632/oncotarget.5136

Bruno Vincenzi, Margherita Nannini, Elena Fumagalli, Giuseppe Bronte, Anna Maria Frezza, Delia De Lisi, Mariella Spalato Ceruso, Daniele Santini, Giuseppe Badalamenti, Maria Abbondanza Pantaleo, Antonio Russo, Angelo Paolo Dei Tos, Paolo Casali,  and Giuseppe Tonini
69412-69419
Abstract  |  PDF  |  HTML  |  Order a Reprint

Novel antibody probes for the characterization of endosialin/TEM-1

Novel antibody probes for the characterization of endosialin/TEM-1

https://doi.org/10.18632/oncotarget.11018

Daniel J. O’Shannessy, Michael F. Smith, Elizabeth B. Somers, Stephen M. Jackson, Earl Albone, Brian Tomkowicz, Xin Cheng, Young Park, Danielle Fernando, Andrew Milinichik, Brad Kline, Regan Fulton, Pankaj Oberoi,  and Nicholas C. Nicolaides
69420-69435
Abstract  |  PDF  |  HTML  |  Order a Reprint

TNFSF15 suppresses VEGF production in endothelial cells by stimulating miR-29b expression via activation of JNK-GATA3 signals

TNFSF15 suppresses VEGF production in endothelial cells by stimulating miR-29b expression via activation of JNK-GATA3 signals

https://doi.org/10.18632/oncotarget.11683

Kun Zhang, Hong-Xing Cai, Shan Gao, Gui-Li Yang, Hui-Ting Deng, Guo-Ce Xu, Jihong Han, Qiang-Zhe Zhang,  and Lu-Yuan Li
69436-69449
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Oncogenic function and clinical implications of SLC3A2-NRG1 fusion in invasive mucinous adenocarcinoma of the lung

Oncogenic function and clinical implications of SLC3A2-NRG1 fusion in invasive mucinous adenocarcinoma of the lung

https://doi.org/10.18632/oncotarget.11913

Dong Hoon Shin, Donghoon Lee, Dong Wan Hong, Seung Hyun Hong, Jung-Ah Hwang, Byung Il Lee, Hye Jin You, Geon Kook Lee, In-Hoo Kim, Yeon-Su Lee,  and Ji-Youn Han
69450-69465
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

GBM-associated mutations and altered protein expression are more common in young patients

GBM-associated mutations and altered protein expression are more common in young patients

https://doi.org/10.18632/oncotarget.11617

Sherise D. Ferguson, Joanne Xiu, Shiao-Pei Weathers, Shouhao Zhou, Santosh Kesari, Stephanie E. Weiss, Roeland G. Verhaak, Raymond J. Hohl, Geoffrey R. Barger, Sandeep K. Reddy,  and Amy B. Heimberger
69466-69478
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Important role of kallikrein 6 for the development of keratinocyte proliferative resistance to topical glucocorticoids

Important role of kallikrein 6 for the development of keratinocyte proliferative resistance to topical glucocorticoids

https://doi.org/10.18632/oncotarget.9926

Mari Kishibe, Gleb Baida, Pankaj Bhalla, Robert M. Lavker, Bethanee Schlosser, Sin Iinuma, Shigetaka Yoshida, Joel T. Dudley,  and Irina Budunova
69479-69488
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Novel regulatory role of neuropilin-1 in endothelial-to-mesenchymal transition and fibrosis in pancreatic ductal adenocarcinoma

Novel regulatory role of neuropilin-1 in endothelial-to-mesenchymal transition and fibrosis in pancreatic ductal adenocarcinoma

https://doi.org/10.18632/oncotarget.11060

Pratiek N. Matkar, Krishna Kumar Singh, Dmitriy Rudenko, Yu Jin Kim, Michael A. Kuliszewski, Gerald J. Prud’homme, David W. Hedley,  and Howard Leong-Poi
69489-69506
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Circulating tumor cells: A promising marker of predicting tumor response in rectal cancer patients receiving neoadjuvant chemo-radiation therapy

Circulating tumor cells: A promising marker of predicting tumor response in rectal cancer patients receiving neoadjuvant chemo-radiation therapy

https://doi.org/10.18632/oncotarget.10875

Wenjie Sun, Guichao Li, Juefeng Wan, Ji Zhu, Weiqi Shen,  and Zhen Zhang
69507-69517
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Targeting hexokinase 2 enhances response to radio-chemotherapy in glioblastoma

Targeting hexokinase 2 enhances response to radio-chemotherapy in glioblastoma

https://doi.org/10.18632/oncotarget.11680

Alenoush Vartanian, Sameer Agnihotri, Mark R. Wilson, Kelly E. Burrell, Peter D. Tonge, Amir Alamsahebpour, Shahrzad Jalali, Michael S. Taccone, Sheila Mansouri, Brian Golbourn, Kenneth D. Aldape,  and Gelareh Zadeh
69518-69535
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MXD1 localizes in the nucleolus, binds UBF and impairs rRNA synthesis

MXD1 localizes in the nucleolus, binds UBF and impairs rRNA synthesis

https://doi.org/10.18632/oncotarget.11766

Maria del Carmen Lafita-Navarro, Rosa Blanco, Jorge Mata-Garrido, Judit Liaño-Pons, Olga Tapia, Lucía García-Gutiérrez, Eva García-Alegría, María T. Berciano, Miguel Lafarga,  and Javier León
69536-69548
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The dominant-negative interplay between p53, p63 and p73: A family affair

The dominant-negative interplay between p53, p63 and p73: A family affair

https://doi.org/10.18632/oncotarget.11774

Olivier Billant, Alice Léon, Solenn Le Guellec, Gaëlle Friocourt, Marc Blondel,  and Cécile Voisset
69549-69564
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Urokinase-type plasminogen activator receptor promotes proliferation and invasion with reduced cisplatin sensitivity in malignant mesothelioma

Urokinase-type plasminogen activator receptor promotes proliferation and invasion with reduced cisplatin sensitivity in malignant mesothelioma

https://doi.org/10.18632/oncotarget.11829

Shenqi Wang, Li Jiang, Yipeng Han, Shan Hwu Chew, Yuuki Ohara, Shinya Akatsuka, Liang Weng, Koji Kawaguchi, Takayuki Fukui, Yoshitaka Sekido, Kohei Yokoi,  and Shinya Toyokuni
69565-69578
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Epigenome-wide association study of smoking and DNA methylation in non-small cell lung neoplasms

Epigenome-wide association study of smoking and DNA methylation in non-small cell lung neoplasms

https://doi.org/10.18632/oncotarget.11831

Joshua R Freeman, Su Chu, Thomas Hsu,  and Yen-Tsung Huang
69579-69591
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

EPRS is a critical regulator of cell proliferation and estrogen signaling in ER+ breast cancer

EPRS is a critical regulator of cell proliferation and estrogen signaling in ER+ breast cancer

https://doi.org/10.18632/oncotarget.11870

Igor Katsyv, Minghui Wang, Won Min Song, Xianxiao Zhou, Yongzhong Zhao, Sun Park, Jun Zhu, Bin Zhang,  and Hanna Y. Irie
69592-69605
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Assessment of bevacizumab resistance increased by expression of BCAT1 in IDH1 wild-type glioblastoma: application of DSC perfusion MR imaging

Assessment of bevacizumab resistance increased by expression of BCAT1 in IDH1 wild-type glioblastoma: application of DSC perfusion MR imaging

https://doi.org/10.18632/oncotarget.11901

Hye Rim Cho, Bora Hong, Hyeonjin Kim, Chul-Kee Park, Sung-Hye Park, Sunghyouk Park,  and Seung Hong Choi
69606-69615
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A panel of 13-miRNA signature as a potential biomarker for predicting survival in pancreatic cancer

A panel of 13-miRNA signature as a potential biomarker for predicting survival in pancreatic cancer

https://doi.org/10.18632/oncotarget.11903

Xin Zhou, Zebo Huang, Lei Xu, Mingxia Zhu, Lan Zhang, Huo Zhang, Xiaping Wang, Hai Li, Wei Zhu, Yongqian Shu,  and Ping Liu
69616-69624
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The pathophysiological significance of PPM1D and therapeutic targeting of PPM1D-mediated signaling by GSK2830371 in mantle cell lymphoma

The pathophysiological significance of PPM1D and therapeutic targeting of PPM1D-mediated signaling by GSK2830371 in mantle cell lymphoma

https://doi.org/10.18632/oncotarget.11904

Kensuke Kojima, Aya Maeda, Mariko Yoshimura, Yuki Nishida,  and Shinya Kimura
69625-69637
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Mutational burdens and evolutionary ages of thyroid follicular adenoma are comparable to those of follicular carcinoma

Mutational burdens and evolutionary ages of thyroid follicular adenoma are comparable to those of follicular carcinoma

https://doi.org/10.18632/oncotarget.11922

Seung-Hyun Jung, Min Sung Kim, Chan Kwon Jung, Hyun-Chun Park, So Youn Kim, Jieying Liu, Ja-Seong Bae, Sung Hak Lee, Tae-Min Kim, Sug Hyung Lee,  and Yeun-Jun Chung
69638-69648
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

CDCP1 is a novel marker of the most aggressive human triple-negative breast cancers

CDCP1 is a novel marker of the most aggressive human triple-negative breast cancers

https://doi.org/10.18632/oncotarget.11935

Federica Turdo, Francesca Bianchi, Patrizia Gasparini, Marco Sandri, Marianna Sasso, Loris De Cecco, Luca Forte, Patrizia Casalini, Piera Aiello, Lucia Sfondrini, Roberto Agresti, Maria Luisa Carcangiu, Ilaria Plantamura, Gabriella Sozzi, Elda Tagliabue,  and Manuela Campiglio
69649-69665
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Prognostic significance of osteopontin expression in gastric cancer: a meta-analysis

Prognostic significance of osteopontin expression in gastric cancer: a meta-analysis

https://doi.org/10.18632/oncotarget.11936

Xiaobin Gu, Xian-Shu Gao, Mingwei Ma, Shangbin Qin, Xin Qi, Xiaoying Li, Shaoqian Sun, Hao Yu, Wen Wang,  and Dong Zhou
69666-69673
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DOT1L promotes angiogenesis through cooperative regulation of VEGFR2 with ETS-1

DOT1L promotes angiogenesis through cooperative regulation of VEGFR2 with ETS-1

https://doi.org/10.18632/oncotarget.11939

Yang Duan, Xue Wu, Qiang Zhao, Jie Gao, Dawei Huo, Xinhua Liu, Zheng Ye, Xu Dong, Zheng Fu, Yongfeng Shang,  and Chenghao Xuan
69674-69687
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The putative oncotarget CSN5 controls a transcription-uncorrelated p53-mediated autophagy implicated in cancer cell survival under curcumin treatment

The putative oncotarget CSN5 controls a transcription-uncorrelated p53-mediated autophagy implicated in cancer cell survival under curcumin treatment

https://doi.org/10.18632/oncotarget.11940

Qing-Yu Zhang, Rui Jin, Xian Zhang, Ji-Po Sheng, Fang Yu, Ren-Xiang Tan, Ying Pan, Jun-Jian Huang,  and Ling-Dong Kong
69688-69702
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Marine compound rhizochalinin shows high in vitro and in vivo efficacy in castration resistant prostate cancer

Marine compound rhizochalinin shows high in vitro and in vivo efficacy in castration resistant prostate cancer

https://doi.org/10.18632/oncotarget.11941

Sergey A. Dyshlovoy, Katharina Otte, Winfried H. Alsdorf, Jessica Hauschild, Tobias Lange, Simone Venz, Christiane K. Bauer, Robert Bähring, Kerstin Amann, Ramin Mandanchi, Udo Schumacher, Jennifer Schröder-Schwarz, Tatyana N. Makarieva, Alla G. Guzii, Kseniya M. Tabakmakher, Sergey N. Fedorov, Larisa K. Shubina, Igor E. Kasheverov, Heimo Ehmke, Thomas Steuber, Valentin A. Stonik, Carsten Bokemeyer, Friedemann Honecker,  and Gunhild von Amsberg
69703-69717
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Toxicological and efficacy assessment of post-transition metal (Indium) phthalocyanine for photodynamic therapy in neuroblastoma

Toxicological and efficacy assessment of post-transition metal (Indium) phthalocyanine for photodynamic therapy in neuroblastoma

https://doi.org/10.18632/oncotarget.11942

Monica Neagu, Carolina Constantin, Mircea Tampa, Clara Matei, Andreea Lupu, Emilia Manole, Rodica-Mariana Ion, Concettina Fenga,  and Aristidis M. Tsatsakis
69718-69732
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Nestin suppression attenuates invasive potential of endometrial cancer cells by downregulating TGF-β signaling pathway

Nestin suppression attenuates invasive potential of endometrial cancer cells by downregulating TGF-β signaling pathway

https://doi.org/10.18632/oncotarget.11947

Amber A. Bokhari, Tabari M. Baker, Batsukh Dorjbal, Sana Waheed, Christopher M. Zahn, Chad A. Hamilton, G. Larry Maxwell,  and Viqar Syed
69733-69748
Abstract  |  PDF  |  HTML  |  Order a Reprint

Programmed death-ligand 1 is upregulated in intrahepatic lymphoepithelioma-like cholangiocarcinoma

Programmed death-ligand 1 is upregulated in intrahepatic lymphoepithelioma-like cholangiocarcinoma

https://doi.org/10.18632/oncotarget.11949

Lei Wang, Hui Dong, Shujuan Ni, Dan Huang, Cong Tan, Bin Chang,  and Weiqi Sheng
69749-69759
Abstract  |  PDF  |  HTML  |  Order a Reprint

Ibrutinib targets mutant-EGFR kinase with a distinct binding conformation

Ibrutinib targets mutant-EGFR kinase with a distinct binding conformation

https://doi.org/10.18632/oncotarget.11951

Aoli Wang, Xiao-E Yan, Hong Wu, Wenchao Wang, Chen Hu, Cheng Chen, Zheng Zhao, Peng Zhao, Xixiang Li, Li Wang, Beilei Wang, Zi Ye, Jinhua Wang, Chu Wang, Wei Zhang, Nathanael S. Gray, Ellen L. Weisberg, Liang Chen, Jing Liu, Cai-Hong Yun,  and Qingsong Liu
69760-69769
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Rottlerin inhibits cell growth and invasion via down-regulation of Cdc20 in glioma cells

Rottlerin inhibits cell growth and invasion via down-regulation of Cdc20 in glioma cells

https://doi.org/10.18632/oncotarget.11974

Lixia Wang, Yingying Hou, Xuyuan Yin, Jingna Su, Zhe Zhao, Xiantao Ye, Xiuxia Zhou, Li Zhou,  and Zhiwei Wang
69770-69782
Abstract  |  PDF  |  HTML  |  Order a Reprint

iOri-Human: identify human origin of replication by incorporating dinucleotide physicochemical properties into pseudo nucleotide composition

iOri-Human: identify human origin of replication by incorporating dinucleotide physicochemical properties into pseudo nucleotide composition

https://doi.org/10.18632/oncotarget.11975

Chang-Jian Zhang, Hua Tang, Wen-Chao Li, Hao Lin, Wei Chen,  and Kuo-Chen Chou
69783-69793
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A simple selection-free method for detecting disseminated tumor cells (DTCs) in murine bone marrow

A simple selection-free method for detecting disseminated tumor cells (DTCs) in murine bone marrow

https://doi.org/10.18632/oncotarget.12000

Kenneth C. Valkenburg, Sarah R. Amend, James E. Verdone, Emma E. van der Toom, James R. Hernandez, Michael A. Gorin,  and Kenneth J. Pienta
69794-69803
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Blocking downstream signaling pathways in the context of HDAC inhibition promotes apoptosis preferentially in cells harboring mutant Ras

Blocking downstream signaling pathways in the context of HDAC inhibition promotes apoptosis preferentially in cells harboring mutant Ras

https://doi.org/10.18632/oncotarget.12001

Julian C. Bahr, Robert W. Robey, Victoria Luchenko, Agnes Basseville, Arup R. Chakraborty, Hanna Kozlowski, Gary T. Pauly, Paresma Patel, Joel P. Schneider, Michael M. Gottesman,  and Susan E. Bates
69804-69815
Abstract  |  PDF  |  HTML  |  Order a Reprint

Large variety in a panel of human colon cancer organoids in response to EZH2 inhibition

Large variety in a panel of human colon cancer organoids in response to EZH2 inhibition

https://doi.org/10.18632/oncotarget.12002

Martijn AJ Koppens, Gergana Bounova, Paulien Cornelissen-Steijger, Nienke de Vries, Owen J Sansom, Lodewyk FA Wessels,  and Maarten van Lohuizen
69816-69828
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Evidence that vitronectin is a potent migration-enhancing factor for cancer cells chaperoned by fibrinogen: a novel view of the metastasis of cancer cells to low-fibrinogen lymphatics and body cavities

Evidence that vitronectin is a potent migration-enhancing factor for cancer cells chaperoned by fibrinogen: a novel view of the metastasis of cancer cells to low-fibrinogen lymphatics and body cavities

https://doi.org/10.18632/oncotarget.12003

Gabriela Schneider, Ewa Bryndza, Agata Poniewierska-Baran, Karol Serwin, Malwina Suszynska, Zachariah P. Sellers, Michael L. Merchant, Alagammai Kaliappan, Janina Ratajczak, Magda Kucia, Nichola C. Garbett,  and Mariusz Z. Ratajczak
69829-69843
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Tissue and imaging biomarkers for hypoxia predict poor outcome in endometrial cancer

Tissue and imaging biomarkers for hypoxia predict poor outcome in endometrial cancer

https://doi.org/10.18632/oncotarget.12004

Anna Berg, Kristine E. Fasmer, Karen K. Mauland, Sigmund Ytre-Hauge, Erling A. Hoivik, Jenny A. Husby, Ingvild L. Tangen, Jone Trovik, Mari K. Halle, Kathrine Woie, Line Bjørge, Atle Bjørnerud, Helga B. Salvesen, Henrica M. J. Werner, Camilla Krakstad,  and Ingfrid S. Haldorsen
69844-69856
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Subpathway-LNCE: Identify dysfunctional subpathways competitively regulated by lncRNAs through integrating lncRNA-mRNA expression profile and pathway topologies

Subpathway-LNCE: Identify dysfunctional subpathways competitively regulated by lncRNAs through integrating lncRNA-mRNA expression profile and pathway topologies

https://doi.org/10.18632/oncotarget.12005

Xinrui Shi, Yanjun Xu, Chunlong Zhang, Li Feng, Zeguo Sun, Junwei Han, Fei Su, Yunpeng Zhang, Chunquan Li,  and Xia Li
69857-69870
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Cadherin-6 type 2, K-cadherin (CDH6) is regulated by mutant p53 in the fallopian tube but is not expressed in the ovarian surface

Cadherin-6 type 2, K-cadherin (CDH6) is regulated by mutant p53 in the fallopian tube but is not expressed in the ovarian surface

https://doi.org/10.18632/oncotarget.11499

Subbulakshmi Karthikeyan, Daniel D. Lantvit, Dam Hee Chae,  and Joanna E. Burdette
69871-69882
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Epithelial-mesenchymal transition and nuclear β-catenin induced by conditional intestinal disruption of Cdh1 with Apc is E-cadherin EC1 domain dependent

Epithelial-mesenchymal transition and nuclear β-catenin induced by conditional intestinal disruption of Cdh1 with Apc is E-cadherin EC1 domain dependent

https://doi.org/10.18632/oncotarget.11513

Julia Matheson, Claudia Bühnemann, Emma J. Carter, David Barnes, Hans-Jürgen Hoppe, Jennifer Hughes, Stephen Cobbold, James Harper, Hans Morreau, Mirvat Surakhy,  and Bassim A. Hassan
69883-69902
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Targeting MET and EGFR crosstalk signaling in triple-negative breast cancers

Targeting MET and EGFR crosstalk signaling in triple-negative breast cancers

https://doi.org/10.18632/oncotarget.12065

Erik S. Linklater, Elizabeth A. Tovar, Curt J. Essenburg, Lisa Turner, Zachary Madaj, Mary E. Winn, Marianne K. Melnik, Hasan Korkaya, Christiane R. Maroun, James G. Christensen, Matthew R. Steensma, Julie L. Boerner,  and Carrie R. Graveel
69903-69915
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Evaluating clinical and prognostic implications of Glypican-3 in hepatocellular carcinoma

Evaluating clinical and prognostic implications of Glypican-3 in hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.12066

Ahmed Omar Kaseb, Manal Hassan, Sahin Lacin, Reham Abdel-Wahab, Hesham M. Amin, Ahmed Shalaby, Robert A. Wolff, James Yao, Asif Rashid, Bharathi Vennapusa, Janine Feng,  and Toshihiko Ohtomo
69916-69926
Abstract  |  PDF  |  HTML  |  Order a Reprint

SMAD4 loss enables EGF, TGFβ1 and S100A8/A9 induced activation of critical pathways to invasion in human pancreatic adenocarcinoma cells

SMAD4 loss enables EGF, TGFβ1 and S100A8/A9 induced activation of critical pathways to invasion in human pancreatic adenocarcinoma cells

https://doi.org/10.18632/oncotarget.12068

Stefania Moz, Daniela Basso, Dania Bozzato, Paola Galozzi, Filippo Navaglia, Ola H. Negm, Giorgio Arrigoni, Carlo-Federico Zambon, Andrea Padoan, Paddy Tighe, Ian Todd, Cinzia Franchin, Sergio Pedrazzoli, Leonardo Punzi,  and Mario Plebani
69927-69944
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Identification of Bisindolylmaleimide IX as a potential agent to treat drug-resistant BCR-ABL positive leukemia

Identification of Bisindolylmaleimide IX as a potential agent to treat drug-resistant BCR-ABL positive leukemia

https://doi.org/10.18632/oncotarget.11566

Xin Zhang, Deyong Jia, Junping Ao, Huijuan Liu, Yi Zang, Mohammad Azam, Samy L. Habib, Jia Li, Xinsen Ruan, Hao Jia, Xueying Wang,  and Baojie Li
69945-69960
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Preclinical investigation of ibrutinib, a Bruton’s kinase tyrosine (Btk) inhibitor, in suppressing glioma tumorigenesis and stem cell phenotypes

Preclinical investigation of ibrutinib, a Bruton’s kinase tyrosine (Btk) inhibitor, in suppressing glioma tumorigenesis and stem cell phenotypes

https://doi.org/10.18632/oncotarget.11572

Li Wei, Yu-Kai Su, Chien-Min Lin, Tsu-Yi Chao, Shang-Pen Huang, Thanh-Tuan Huynh, Hsun-Jin Jan, Jacqueline Whang-Peng, Jeng-Fong Chiou, Alexander T.H. Wu,  and Michael Hsiao
69961-69975
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Fibroblast growth factor receptor 4 induced resistance to radiation therapy in colorectal cancer

Fibroblast growth factor receptor 4 induced resistance to radiation therapy in colorectal cancer

https://doi.org/10.18632/oncotarget.12099

Mohamed A. Ahmed, Edgar Selzer, Wolfgang Dörr, Gerd Jomrich, Felix Harpain, Gerd R. Silberhumer, Leonhard Müllauer, Klaus Holzmann, Bettina Grasl-Kraupp, Michael Grusch, Walter Berger,  and Brigitte Marian
69976-69990
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A three-gene signature for prognosis in patients with MGMT promoter-methylated glioblastoma

A three-gene signature for prognosis in patients with MGMT promoter-methylated glioblastoma

https://doi.org/10.18632/oncotarget.11726

Wen Wang, Lu Zhang, Zheng Wang, Fan Yang, Haoyuan Wang, Tingyu Liang, Fan Wu, Qing Lan, Jiangfei Wang,  and Jizong Zhao
69991-69999
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Acquired resistance to venetoclax (ABT-199) in t(14;18) positive lymphoma cells

Acquired resistance to venetoclax (ABT-199) in t(14;18) positive lymphoma cells

https://doi.org/10.18632/oncotarget.12132

Juraj Bodo, Xiaoxian Zhao, Lisa Durkin, Andrew J. Souers, Darren C. Phillips, Mitchell R. Smith,  and Eric D. Hsi
70000-70010
Abstract  |  PDF  |  HTML  |  Order a Reprint

ABCB1 and ABCC11 confer resistance to eribulin in breast cancer cell lines

ABCB1 and ABCC11 confer resistance to eribulin in breast cancer cell lines

https://doi.org/10.18632/oncotarget.11727

Takaaki Oba, Hiroto Izumi,  and Ken-ichi Ito
70011-70027
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Targeting Notch signaling as a novel therapy for retinoblastoma

Targeting Notch signaling as a novel therapy for retinoblastoma

https://doi.org/10.18632/oncotarget.12142

Laura Asnaghi, Arushi Tripathy, Qian Yang, Harpreet Kaur, Allison Hanaford, Wayne Yu,  and Charles G. Eberhart
70028-70044
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Paraoxonase 3 inhibits cell proliferation and serves as a prognostic predictor in hepatocellular carcinoma

Paraoxonase 3 inhibits cell proliferation and serves as a prognostic predictor in hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.12145

Jie Cai, Sheng-Xian Yuan, Fu Yang, Qi-Fei Tao, Yuan Yang, Qing-Guo Xu, Zhen-Guang Wang, Jian Yu, Kong-Ying Lin, Zong-Yan Wang, Jin-Zhao Ma, Chuan-Chuan Zhou, Fang Wang, Shu-Han Sun,  and Wei-Ping Zhou
70045-70057
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

miR-204 suppresses the development and progression of human glioblastoma by targeting ATF2

miR-204 suppresses the development and progression of human glioblastoma by targeting ATF2

https://doi.org/10.18632/oncotarget.11732

Shiwei Song, Abul Fajol, Xiankun Tu, Baogang Ren,  and Songsheng Shi
70058-70065
Abstract  |  PDF  |  HTML  |  Order a Reprint

Meta-analysis comparing chewing gum versus standard postoperative care after colorectal resection

Meta-analysis comparing chewing gum versus standard postoperative care after colorectal resection

https://doi.org/10.18632/oncotarget.11735

Guo-Min Song, Yong-Hong Deng, Ying-Hui Jin, Jian-Guo Zhou,  and Xu Tian
70066-70079
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

FRMD6 inhibits human glioblastoma growth and progression by negatively regulating activity of receptor tyrosine kinases

FRMD6 inhibits human glioblastoma growth and progression by negatively regulating activity of receptor tyrosine kinases

https://doi.org/10.18632/oncotarget.12148

Yin Xu, Kaiqiang Wang,  and Qin Yu
70080-70091
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Gemcitabine inhibits immune escape of pancreatic cancer by down regulating the soluble ULBP2 protein

Gemcitabine inhibits immune escape of pancreatic cancer by down regulating the soluble ULBP2 protein

https://doi.org/10.18632/oncotarget.11780

Xiansheng Lin, Mei Huang, Fang Xie, Hangcheng Zhou, Ji Yang,  and Qiang Huang
70092-70099
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Secondary nuclear targeting of mesoporous silica nano-particles for cancer-specific drug delivery based on charge inversion

Secondary nuclear targeting of mesoporous silica nano-particles for cancer-specific drug delivery based on charge inversion

https://doi.org/10.18632/oncotarget.12149

Jianwen Zhao, Fengfeng Zhao, Xiyong Wang, Xiaobo Fan,  and Guoqiu Wu
70100-70112
Abstract  |  PDF  |  HTML  |  Order a Reprint

BRCA mutations and survival in breast cancer: an updated systematic review and meta-analysis

BRCA mutations and survival in breast cancer: an updated systematic review and meta-analysis

https://doi.org/10.18632/oncotarget.12158

Yaning Zhu, Jian Wu, Chengwan Zhang, Suan Sun, Jian Zhang, Wenjie Liu, Jian Huang,  and Zhihong Zhang
70113-70127
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Efficacy of D5F3 IHC for detecting ALK gene rearrangement in NSCLC patients: a systematic review and meta-analysis

Efficacy of D5F3 IHC for detecting ALK gene rearrangement in NSCLC patients: a systematic review and meta-analysis

https://doi.org/10.18632/oncotarget.11806

Hu Ma, Wen-Xiu Yao, Lang Huang, Su-Han Jin, Da-Hai Liu, Yuan Liu, Xu Tian, Jin-Hui Tian,  and Jian-Guo Zhou
70128-70142
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Interferon-stimulated gene 15 induces cancer cell death by suppressing the NF-κB signaling pathway

Interferon-stimulated gene 15 induces cancer cell death by suppressing the NF-κB signaling pathway

https://doi.org/10.18632/oncotarget.12160

Hongwu Mao, Man Wang, Biyin Cao, Haibin Zhou, Zubin Zhang,  and Xinliang Mao
70143-70151
Abstract  |  PDF  |  HTML  |  Order a Reprint

Nodal signaling promotes vasculogenic mimicry formation in breast cancer via the Smad2/3 pathway

Nodal signaling promotes vasculogenic mimicry formation in breast cancer via the Smad2/3 pathway

https://doi.org/10.18632/oncotarget.12161

Wenchen Gong, Baocun Sun, Xiulan Zhao, Danfang Zhang, Junying Sun, Tieju Liu, Qiang Gu, Xueyi Dong, Fang Liu, Yong Wang, Xian Lin,  and Yanlei Li
70152-70167
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A dose increased once-weekly bortezomib-based combination therapy for multiple myeloma

A dose increased once-weekly bortezomib-based combination therapy for multiple myeloma

https://doi.org/10.18632/oncotarget.12162

Daolin Wei, Yin Tong, Haitao Bai, Qi Cai, Yanrong Gao,  and Chun Wang
70168-70174
Abstract  |  PDF  |  HTML  |  Order a Reprint

MMP-1 promoter polymorphism is associated with risk of radiation-induced lung injury in lung cancer patients treated with radiotherapy

MMP-1 promoter polymorphism is associated with risk of radiation-induced lung injury in lung cancer patients treated with radiotherapy

https://doi.org/10.18632/oncotarget.12164

Bo Liu, Minxiao Yi, Yang Tang, Qingxu Liu, Hong Qiu, Yanmei Zou, Ping Peng, Lu Zhang, Chunping Hu,  and Xianglin Yuan
70175-70184
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A meta-analysis of weekly cisplatin versus three weekly cisplatin chemotherapy plus concurrent radiotherapy (CRT) for advanced head and neck cancer (HNC)

A meta-analysis of weekly cisplatin versus three weekly cisplatin chemotherapy plus concurrent radiotherapy (CRT) for advanced head and neck cancer (HNC)

https://doi.org/10.18632/oncotarget.11824

Jian Guan, Yue Zhang, Qinyang Li, Yaowei Zhang, Lu Li, Min Chen, Nanjie Xiao,  and Longhua Chen
70185-70193
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MicroRNA-552 enhances metastatic capacity of colorectal cancer cells by targeting a disintegrin and metalloprotease 28

MicroRNA-552 enhances metastatic capacity of colorectal cancer cells by targeting a disintegrin and metalloprotease 28

https://doi.org/10.18632/oncotarget.12169

Jian Wang, Hai Li, Yong Wang, Libin Wang, Xiurui Yan, Dong Zhang, Xiaoqiang Ma, Yong Du, Xiaoming Liu,  and Yinxue Yang
70194-70210
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

SPARC expression in gastric cancer predicts poor prognosis: Results from a clinical cohort, pooled analysis and GSEA assay

SPARC expression in gastric cancer predicts poor prognosis: Results from a clinical cohort, pooled analysis and GSEA assay

https://doi.org/10.18632/oncotarget.12191

Zhi Li, Ao-Di Li, Lu Xu, De-Wei Bai, Ke-Zuo Hou, Hua-Chuan Zheng, Xiu-Juan Qu,  and Yun-Peng Liu
70211-70222
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

CpG-induced antitumor immunity requires IL-12 in expansion of effector cells and down-regulation of PD-1

CpG-induced antitumor immunity requires IL-12 in expansion of effector cells and down-regulation of PD-1

https://doi.org/10.18632/oncotarget.11833

Peng Yin, Xin Liu, Aaron S. Mansfield, Susan M. Harrington, Yinghua Li, Yiyi Yan,  and Haidong Dong
70223-70231
Abstract  |  PDF  |  HTML  |  Order a Reprint

Endothelin-1 promotes epithelial–mesenchymal transition in human chondrosarcoma cells by repressing miR-300

Endothelin-1 promotes epithelial–mesenchymal transition in human chondrosarcoma cells by repressing miR-300

https://doi.org/10.18632/oncotarget.11835

Min-Huan Wu, Pei-Han Huang, Mingli Hsieh, Chun-Hao Tsai, Hsien-Te Chen,  and Chih-Hsin Tang
70232-70246
Abstract  |  PDF  |  HTML  |  Order a Reprint

IL-24 modulates the high mobility group (HMG) A1/miR222 /AKT signaling in lung cancer cells

IL-24 modulates the high mobility group (HMG) A1/miR222 /AKT signaling in lung cancer cells

https://doi.org/10.18632/oncotarget.11838

Janani Panneerselvam, Akhil Srivastava, Ranganayaki Muralidharan, Qi Wang, Wei Zheng, Lichao Zhao, Alshine Chen, Yan D. Zhao, Anupama Munshi,  and Rajagopal Ramesh
70247-70263
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Pre-existing mutations related to tenofovir in chronic hepatitis B patients with long-term nucleos(t)ide analogue drugs treatment by ultra-deep pyrosequencing

Pre-existing mutations related to tenofovir in chronic hepatitis B patients with long-term nucleos(t)ide analogue drugs treatment by ultra-deep pyrosequencing

https://doi.org/10.18632/oncotarget.11840

Xiaxia Zhang, Minran Li, Hongli Xi, Renwen Zhang, Jianhong Chen, Yu Zhang,  and Xiaoyuan Xu
70264-70275
Abstract  |  PDF  |  HTML  |  Order a Reprint

Polyphyllin G induce apoptosis and autophagy in human nasopharyngeal cancer cells by modulation of AKT and mitogen-activated protein kinase pathways in vitro and in vivo

Polyphyllin G induce apoptosis and autophagy in human nasopharyngeal cancer cells by modulation of AKT and mitogen-activated protein kinase pathways in vitro and in vivo

https://doi.org/10.18632/oncotarget.11839

Jui-Chieh Chen, Ming-Ju Hsieh, Chih-Jung Chen, Jen-Tsun Lin, Yu-Sheng Lo, Yi-Ching Chuang, Su-Yu Chien,  and Mu-Kuan Chen
70276-70289
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The clock gene PER1 plays an important role in regulating the clock gene network in human oral squamous cell carcinoma cells

The clock gene PER1 plays an important role in regulating the clock gene network in human oral squamous cell carcinoma cells

https://doi.org/10.18632/oncotarget.11844

Qin Zhao, Gang Zheng, Kai Yang, Yi-ran Ao, Xiao-li Su, Yu Li,  and Xiao-qiang Lv
70290-70302
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

NTS/NTR1 co-expression enhances epithelial-to-mesenchymal transition and promotes tumor metastasis by activating the Wnt/β-catenin signaling pathway in hepatocellular carcinoma

NTS/NTR1 co-expression enhances epithelial-to-mesenchymal transition and promotes tumor metastasis by activating the Wnt/β-catenin signaling pathway in hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.11854

Yingnan Ye, Xinxin Long, Lijie Zhang, Jieying Chen, Pengpeng Liu, Hui Li, Feng Wei, Wenwen Yu, Xiubao Ren,  and Jinpu Yu
70303-70322
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

ATAD2 is an epigenetic reader of newly synthesized histone marks during DNA replication

ATAD2 is an epigenetic reader of newly synthesized histone marks during DNA replication

https://doi.org/10.18632/oncotarget.11855

Seong Joo Koo, Amaury E. Fernández-Montalván, Volker Badock, Christopher J. Ott, Simon J. Holton, Oliver von Ahsen, Joern Toedling, Sarah Vittori, James E. Bradner,  and Mátyás Gorjánácz
70323-70335
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Oncogenic activation of FAK drives apoptosis suppression in a 3D-culture model of breast cancer initiation

Oncogenic activation of FAK drives apoptosis suppression in a 3D-culture model of breast cancer initiation

https://doi.org/10.18632/oncotarget.11856

Scott Walker, Fiona Foster, Amber Wood, Thomas Owens, Keith Brennan, Charles H. Streuli,  and Andrew P. Gilmore
70336-70352
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Pathologic heterogeneity of lung adenocarcinomas: A novel pathologic index predicts survival

Pathologic heterogeneity of lung adenocarcinomas: A novel pathologic index predicts survival

https://doi.org/10.18632/oncotarget.11857

Geewon Lee, E-Ryung Choi, Ho Yun Lee, Ji Yun Jeong, Joong Hyun Ahn, Seonwoo Kim, Jungmin Bae, Hong Kwan Kim, Yong Soo Choi, Jhingook Kim, Jaeil Zo, Kyung Soo Lee,  and Young Mog Shim
70353-70363
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Induction of epithelial-mesenchymal transition (EMT) by Beclin 1 knockdown via posttranscriptional upregulation of ZEB1 in thyroid cancer cells

Induction of epithelial-mesenchymal transition (EMT) by Beclin 1 knockdown via posttranscriptional upregulation of ZEB1 in thyroid cancer cells

https://doi.org/10.18632/oncotarget.12217

Si Li, Hai-Yan Zhang, Zhen-Xian Du, Chao Li, Ming-Xin An, Zhi-Hong Zong, Bao-Qin Liu,  and Hua-Qin Wang
70364-70377
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Dickkopf-1 expression is associated with tumorigenity and lymphatic metastasis in human hilar cholangiocarcinoma

Dickkopf-1 expression is associated with tumorigenity and lymphatic metastasis in human hilar cholangiocarcinoma

https://doi.org/10.18632/oncotarget.11859

Xiang-de Shi, Xian-huan Yu, Wen-rui Wu, Xiao-lin Xu, Jie-Yu Wang, Lei-bo Xu, Rui Zhang,  and Chao Liu
70378-70387
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Novel tumor suppressor microRNA at frequently deleted chromosomal region 8p21 regulates Epidermal Growth Factor Receptor in prostate cancer

Novel tumor suppressor microRNA at frequently deleted chromosomal region 8p21 regulates Epidermal Growth Factor Receptor in prostate cancer

https://doi.org/10.18632/oncotarget.11865

Nathan Bucay, Kirandeep Sekhon, Shahana Majid, Soichiro Yamamura, Varahram Shahryari, Z. Laura Tabatabai, Kirsten Greene, Yuichiro Tanaka, Rajvir Dahiya, Guoren Deng,  and Sharanjot Saini
70388-70403
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Androgen receptor differentially regulates the proliferation of prostatic epithelial cells in vitro and in vivo

Androgen receptor differentially regulates the proliferation of prostatic epithelial cells in vitro and in vivo

https://doi.org/10.18632/oncotarget.11879

Shu Yang, Ming Jiang, Magdalena M. Grabowska, Jiahe Li, Zachary M. Connelly, Jianghong Zhang, Simon W. Hayward, Justin M. Cates, Guichun Han,  and Xiuping Yu
70404-70419
Abstract  |  PDF  |  HTML  |  Order a Reprint

Loss of ZNF32 augments the regeneration of nervous lateral line system through negative regulation of SOX2 transcription

Loss of ZNF32 augments the regeneration of nervous lateral line system through negative regulation of SOX2 transcription

https://doi.org/10.18632/oncotarget.11895

Yuyan Wei, Kai Li, Shaohua Yao, Junping Gao, Jun Li, Yanna Shang, Jie Zhang, Le Zhang, Yanyan Li, Xianming Mo, Wentong Meng, Rong Xiang, Jiankun Hu, Ping Lin,  and Yuquan Wei
70420-70436
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Zanthoxylum fruit extract from Japanese pepper promotes autophagic cell death in cancer cells

Zanthoxylum fruit extract from Japanese pepper promotes autophagic cell death in cancer cells

https://doi.org/10.18632/oncotarget.11926

Reo Nozaki, Toru Kono, Hiroki Bochimoto, Tsuyoshi Watanabe, Kaori Oketani, Yuichi Sakamaki, Naoto Okubo, Koji Nakagawa,  and Hiroshi Takeda
70437-70446
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A vicious cycle between acid sensing and survival signaling in myeloma cells: acid-induced epigenetic alteration

A vicious cycle between acid sensing and survival signaling in myeloma cells: acid-induced epigenetic alteration

https://doi.org/10.18632/oncotarget.11927

Ryota Amachi, Masahiro Hiasa, Jumpei Teramachi, Takeshi Harada, Asuka Oda, Shingen Nakamura, Derek Hanson, Keiichiro Watanabe, Shiro Fujii, Hirokazu Miki, Kumiko Kagawa, Masami Iwasa, Itsuro Endo, Takeshi Kondo, Sumiko Yoshida, Ken-ichi Aihara, Kiyoe Kurahashi, Yoshiaki Kuroda, Hideaki Horikawa, Eiji Tanaka, Toshio Matsumoto,  and Masahiro Abe
70447-70461
Abstract  |  PDF  |  HTML  |  Order a Reprint

A microRNA/Runx1/Runx2 network regulates prostate tumor progression from onset to adenocarcinoma in TRAMP mice

A microRNA/Runx1/Runx2 network regulates prostate tumor progression from onset to adenocarcinoma in TRAMP mice

https://doi.org/10.18632/oncotarget.11992

Nicholas H. Farina, Areg Zingiryan, Jacqueline A. Akech, Cody J. Callahan, Huimin Lu, Janet L. Stein, Lucia R. Languino, Gary S. Stein,  and Jane B. Lian
70462-70474
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

RTEL1 polymorphisms are associated with lung cancer risk in the Chinese Han population

RTEL1 polymorphisms are associated with lung cancer risk in the Chinese Han population

https://doi.org/10.18632/oncotarget.12297

Shouchun Yan, Ridong Xia, Tianbo Jin, Hui Ren, Hua Yang, Jing Li, Mengdan Yan, Yuanyuan Zhu,  and Mingwei Chen
70475-70480
Abstract  |  PDF  |  HTML  |  Order a Reprint

Identification of the APC/C co-factor FZR1 as a novel therapeutic target for multiple myeloma

Identification of the APC/C co-factor FZR1 as a novel therapeutic target for multiple myeloma

https://doi.org/10.18632/oncotarget.12026

Lisa J. Crawford, Gordon Anderson, Cliona K. Johnston,  and Alexandra E. Irvine
70481-70493
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

COL3A1 and SNAP91: novel glioblastoma markers with diagnostic and prognostic value

COL3A1 and SNAP91: novel glioblastoma markers with diagnostic and prognostic value

https://doi.org/10.18632/oncotarget.12038

Yuan-Feng Gao, Xiao-Yuan Mao, Tao Zhu, Chen-Xue Mao, Zhi-Xiong Liu, Zhi-Bin Wang, Ling Li, Xi Li, Ji-Ye Yin, Wei Zhang, Hong-Hao Zhou,  and Zhao-Qian Liu
70494-70503
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Shikonin potentiates the effect of arsenic trioxide against human hepatocellular carcinoma in vitro and in vivo

Shikonin potentiates the effect of arsenic trioxide against human hepatocellular carcinoma in vitro and in vivo

https://doi.org/10.18632/oncotarget.12041

Jingjing Song, Zhongwei Zhao, Xiaoxi Fan, Minjiang Chen, Xingyao Cheng, Dengke Zhang, Fazong Wu, Xihui Ying,  and Jiansong Ji
70504-70515
Abstract  |  PDF  |  HTML  |  Order a Reprint

Analysis of the variability among radiation oncologists in delineation of the postsurgical tumor bed based on 4D-CT

Analysis of the variability among radiation oncologists in delineation of the postsurgical tumor bed based on 4D-CT

https://doi.org/10.18632/oncotarget.12044

Wei Wang, Jianbin Li, Jun Xing, Min Xu, Qian Shao, Tingyong Fan, Bing Guo,  and Shanshan Liu
70516-70523
Abstract  |  PDF  |  HTML  |  Order a Reprint

Primary and recurrent ovarian high-grade serous carcinomas display similar microRNA expression patterns relative to those of normal ovarian tissue

Primary and recurrent ovarian high-grade serous carcinomas display similar microRNA expression patterns relative to those of normal ovarian tissue

https://doi.org/10.18632/oncotarget.12045

Eun Ji Nam, Sunghoon Kim, Taek Sang Lee, Hee Jung Kim, Jung Yun Lee, Sang Wun Kim, Jae Hoon Kim,  and Young Tae Kim
70524-70534
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Clinical benefit from EGFR-TKI plus ginsenoside Rg3 in patients with advanced non-small cell lung cancer harboring EGFR active mutation

Clinical benefit from EGFR-TKI plus ginsenoside Rg3 in patients with advanced non-small cell lung cancer harboring EGFR active mutation

https://doi.org/10.18632/oncotarget.12059

Yan Li, Yanmei Wang, Kai Niu, Xiewan Chen, Liqin Xia, Dingxi Lu, Rui Kong, Zhengtang Chen, Yuzhong Duan,  and Jianguo Sun
70535-70545
Abstract  |  PDF  |  HTML  |  Order a Reprint

Deptor transcriptionally regulates endoplasmic reticulum homeostasis in multiple myeloma cells

Deptor transcriptionally regulates endoplasmic reticulum homeostasis in multiple myeloma cells

https://doi.org/10.18632/oncotarget.12060

Valeria Catena, Tiziana Bruno, Francesca De Nicola, Frauke Goeman, Matteo Pallocca, Simona Iezzi, Cristina Sorino, Giovanni Cigliana, Aristide Floridi, Giovanni Blandino,  and Maurizio Fanciulli
70546-70558
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Hepatitis B virus X induces inflammation and cancer in mice liver through dysregulation of cytoskeletal remodeling and lipid metabolism

Hepatitis B virus X induces inflammation and cancer in mice liver through dysregulation of cytoskeletal remodeling and lipid metabolism

https://doi.org/10.18632/oncotarget.12372

Zhongwei Xu, Linghui Zhai, Tailong Yi, Huiying Gao, Fengxu Fan, Yanchang Li, Youliang Wang, Ning Li, Xiaohua Xing, Na Su, Feilin Wu, Lei Chang, Xiuli Chen, Erhei Dai, Chao Zhao, Xiao Yang, Chunping Cui,  and Ping Xu
70559-70574
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

TWIST1/miR-584/TUSC2 pathway induces resistance to apoptosis in thyroid cancer cells

TWIST1/miR-584/TUSC2 pathway induces resistance to apoptosis in thyroid cancer cells

https://doi.org/10.18632/oncotarget.12129

Francesca Maria Orlandella, Gennaro Di Maro, Clara Ugolini, Fulvio Basolo,  and Giuliana Salvatore
70575-70588
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

RNF43 and ZNRF3 are commonly altered in serrated pathway colorectal tumorigenesis

RNF43 and ZNRF3 are commonly altered in serrated pathway colorectal tumorigenesis

https://doi.org/10.18632/oncotarget.12130

Catherine E. Bond, Diane M. McKeone, Murugan Kalimutho, Mark L. Bettington, Sally-Ann Pearson, Troy D. Dumenil, Leesa F. Wockner, Matthew Burge, Barbara A. Leggett,  and Vicki L.J. Whitehall
70589-70600
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Relationship between tumour PTEN/Akt/COX-2 expression, inflammatory response and survival in patients with colorectal cancer

Relationship between tumour PTEN/Akt/COX-2 expression, inflammatory response and survival in patients with colorectal cancer

https://doi.org/10.18632/oncotarget.12134

Antonia K. Roseweir, Arfon GMT Powell, Lindsay Bennett, Hester C. Van Wyk, James Park, Donald C. McMillan, Paul G. Horgan,  and Joanne Edwards
70601-70612
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

miR-135b expression downregulates Ppm1e to activate AMPK signaling and protect osteoblastic cells from dexamethasone

miR-135b expression downregulates Ppm1e to activate AMPK signaling and protect osteoblastic cells from dexamethasone

https://doi.org/10.18632/oncotarget.12138

Jian-Bo Fan, Jian-Wei Ruan, Wei Liu, Lun-Qing Zhu, Xin-Hui Zhu, Hong Yi, Sheng-Yu Cui, Jian-Ning Zhao,  and Zhi-Ming Cui
70613-70622
Abstract  |  PDF  |  HTML  |  Order a Reprint

Ibrutinib synergizes with MDM-2 inhibitors in promoting cytotoxicity in B chronic lymphocytic leukemia

Ibrutinib synergizes with MDM-2 inhibitors in promoting cytotoxicity in B chronic lymphocytic leukemia

https://doi.org/10.18632/oncotarget.12139

Rebecca Voltan, Erika Rimondi, Elisabetta Melloni, Gian Matteo Rigolin, Fabio Casciano, Maria Vittoria Arcidiacono, Claudio Celeghini, Antonio Cuneo, Giorgio Zauli,  and Paola Secchiero
70623-70638
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Characterization of acetate transport in colorectal cancer cells and potential therapeutic implications

Characterization of acetate transport in colorectal cancer cells and potential therapeutic implications

https://doi.org/10.18632/oncotarget.12156

Suellen Ferro, João Azevedo-Silva, Margarida Casal, Manuela Côrte-Real, Fatima Baltazar,  and Ana Preto
70639-70653
Abstract  |  PDF  |  HTML  |  Order a Reprint

Apolipoprotein A1: a novel serum biomarker for predicting the prognosis of hepatocellular carcinoma after curative resection

Apolipoprotein A1: a novel serum biomarker for predicting the prognosis of hepatocellular carcinoma after curative resection

https://doi.org/10.18632/oncotarget.12203

Xiao-Lu Ma, Xing-Hui Gao, Zi-Jun Gong, Jiong Wu, Lu Tian, Chun-Yan Zhang, Yan Zhou, Yun-Fan Sun, Bo Hu, Shuang-jian Qiu, Jian Zhou, Jia Fan, Wei Guo,  and Xin-Rong Yang
70654-70668
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Human PDE4D isoform composition is deregulated in primary prostate cancer and indicative for disease progression and development of distant metastases

Human PDE4D isoform composition is deregulated in primary prostate cancer and indicative for disease progression and development of distant metastases

https://doi.org/10.18632/oncotarget.12204

René Böttcher, Kalyan Dulla, Dianne van Strijp, Natasja Dits, Esther I. Verhoef, George S. Baillie, Geert J.L.H. van Leenders, Miles D. Houslay, Guido Jenster,  and Ralf Hoffmann
70669-70684
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Pseudoexons provide a mechanism for allele-specific expression of APC in familial adenomatous polyposis

Pseudoexons provide a mechanism for allele-specific expression of APC in familial adenomatous polyposis

https://doi.org/10.18632/oncotarget.12206

Taina T. Nieminen, Walter Pavicic, Noora Porkka, Matti Kankainen, Heikki J. Järvinen, Anna Lepistö,  and Päivi Peltomäki
70685-70698
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

miR-135a promotes gastric cancer progression and resistance to oxaliplatin

miR-135a promotes gastric cancer progression and resistance to oxaliplatin

https://doi.org/10.18632/oncotarget.12208

Lin-Hai Yan, Zhi-Ning Chen, Li -Li, Jia Chen, Wen-E Wei, Xian-Wei Mo, Yu-Zhou Qin, Yuan Lin,  and Jian-Si Chen
70699-70714
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Glutathione-mediated antioxidant response and aerobic metabolism: two crucial factors involved in determining the multi-drug resistance of high-risk neuroblastoma

Glutathione-mediated antioxidant response and aerobic metabolism: two crucial factors involved in determining the multi-drug resistance of high-risk neuroblastoma

https://doi.org/10.18632/oncotarget.12209

Renata Colla, Alberto Izzotti, Chiara De Ciucis, Daniela Fenoglio, Silvia Ravera, Andrea Speciale, Roberta Ricciarelli, Anna Lisa Furfaro, Alessandra Pulliero, Mario Passalacqua, Nicola Traverso, Maria Adelaide Pronzato, Cinzia Domenicotti,  and Barbara Marengo
70715-70737
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

ESM1 mediates NGFR-induced invasion and metastasis in murine oral squamous cell carcinoma

ESM1 mediates NGFR-induced invasion and metastasis in murine oral squamous cell carcinoma

https://doi.org/10.18632/oncotarget.12210

Chen Chen, June Ho Shin, Joshua T. Eggold, Man Ki Chung, Luhua H. Zhang, Jeremy Lee,  and John B. Sunwoo
70738-70749
Abstract  |  PDF  |  HTML  |  Order a Reprint

Silencing of Profilin-1 suppresses cell adhesion and tumor growth via predicted alterations in integrin and Ca2+ signaling in T24M-based bladder cancer models

Silencing of Profilin-1 suppresses cell adhesion and tumor growth via predicted alterations in integrin and Ca2+ signaling in T24M-based bladder cancer models

https://doi.org/10.18632/oncotarget.12218

Maria Frantzi, Zoi Klimou, Manousos Makridakis, Jerome Zoidakis, Agnieszka Latosinska, Daniel M. Borràs, Bart Janssen, Ioanna Giannopoulou, Vasiliki Lygirou, Andreas C. Lazaris, Nicholas P. Anagnou, Harald Mischak, Maria G. Roubelakis,  and Antonia Vlahou
70750-70768
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Long non-coding RNAs LOC285194, RP11-462C24.1 and Nbla12061 in serum provide a new approach for distinguishing patients with colorectal cancer from healthy controls

Long non-coding RNAs LOC285194, RP11-462C24.1 and Nbla12061 in serum provide a new approach for distinguishing patients with colorectal cancer from healthy controls

https://doi.org/10.18632/oncotarget.12220

Chuanxi Wang, Jinyu Yu, Yuping Han, Leping Li, Jie Li, Tao Li,  and Peng Qi
70769-70778
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Different growth and metastatic phenotypes associated with a cell-intrinsic change of Met in metastatic melanoma

Different growth and metastatic phenotypes associated with a cell-intrinsic change of Met in metastatic melanoma

https://doi.org/10.18632/oncotarget.12221

Eri Adachi, Katsuya Sakai, Takumi Nishiuchi, Ryu Imamura, Hiroki Sato,  and Kunio Matsumoto
70779-70793
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Randomized, placebo-controlled trial evaluating the safety of one-year administration of green tea catechins

Randomized, placebo-controlled trial evaluating the safety of one-year administration of green tea catechins

https://doi.org/10.18632/oncotarget.12222

Nagi B. Kumar, Julio Pow-Sang, Philippe E. Spiess, Jong Park, Raoul Salup, Christopher R. Williams, Howard Parnes,  and Michael J. Schell
70794-70802
Abstract  |  PDF  |  HTML  |  Order a Reprint

The changing 50% inhibitory concentration (IC50) of cisplatin: a pilot study on the artifacts of the MTT assay and the precise measurement of density-dependent chemoresistance in ovarian cancer

The changing 50% inhibitory concentration (IC50) of cisplatin: a pilot study on the artifacts of the MTT assay and the precise measurement of density-dependent chemoresistance in ovarian cancer

https://doi.org/10.18632/oncotarget.12223

Yifeng He, Qiujing Zhu, Mo Chen, Qihong Huang, Wenjing Wang, Qing Li, Yuting Huang,  and Wen Di
70803-70821
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Development of a selected reaction monitoring mass spectrometry-based assay to detect asparaginyl endopeptidase activity in biological fluids

Development of a selected reaction monitoring mass spectrometry-based assay to detect asparaginyl endopeptidase activity in biological fluids

https://doi.org/10.18632/oncotarget.12224

Anindita Dutta, David N. Potier, Michael J. Walker, Oliver J. Gray, Catriona Parker, Mark Holland, Andrew J.K. Williamson, Andrew Pierce, Richard D. Unwin, Shekhar Krishnan, Vaskar Saha,  and Anthony D. Whetton
70822-70831
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Reduced argininosuccinate synthetase expression in refractory sarcomas: Impacts on therapeutic potential and drug resistance

Reduced argininosuccinate synthetase expression in refractory sarcomas: Impacts on therapeutic potential and drug resistance

https://doi.org/10.18632/oncotarget.12225

Youngji Kim, Eisuke Kobayashi, Daisuke Kubota, Yoshiyuki Suehara, Kenta Mukaihara, Keisuke Akaike, Ayumu Ito, Kazuo Kaneko, Hirokazu Chuman, Akira Kawai,  and Shigehisa Kitano
70832-70844
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Hydroxychloroquine potentiates carfilzomib toxicity towards myeloma cells

Hydroxychloroquine potentiates carfilzomib toxicity towards myeloma cells

https://doi.org/10.18632/oncotarget.12226

Katarzyna Baranowska, Kristine Misund, Kristian K. Starheim, Toril Holien, Ida Johansson, Sagar Darvekar, Glenn Buene, Anders Waage, Geir Bjørkøy,  and Anders Sundan
70845-70856
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MiRNA-145 increases therapeutic sensibility to gemcitabine treatment of pancreatic adenocarcinoma cells

MiRNA-145 increases therapeutic sensibility to gemcitabine treatment of pancreatic adenocarcinoma cells

https://doi.org/10.18632/oncotarget.12268

Yong Lin, Xin Ge, Yiyang Wen, Zhu-Mei Shi, Qiu-Dan Chen, Min Wang, Ling-Zhi Liu, Bing-Hua Jiang,  and Yuan Lu
70857-70868
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Zoledronic acid is an effective radiosensitizer in the treatment of osteosarcoma

Zoledronic acid is an effective radiosensitizer in the treatment of osteosarcoma

https://doi.org/10.18632/oncotarget.12281

Eun Ho Kim, Mi-Sook Kim, Kyung-Hee Lee, Jae-Soo Koh, Won-Gyun Jung,  and Chang-Bae Kong
70869-70880
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

PAK4 suppresses PDZ-RhoGEF activity to drive invadopodia maturation in melanoma cells

PAK4 suppresses PDZ-RhoGEF activity to drive invadopodia maturation in melanoma cells

https://doi.org/10.18632/oncotarget.12282

Nicole S. Nicholas, Aikaterini Pipili, Michaela S. Lesjak, Simon M. Ameer-Beg, Jenny L. C. Geh, Ciaran Healy, Alistair D. MacKenzie Ross, Maddy Parsons, Frank O. Nestle, Katie E. Lacy,  and Claire M. Wells
70881-70897
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

G-protein-coupled receptor 81 promotes a malignant phenotype in breast cancer through angiogenic factor secretion

G-protein-coupled receptor 81 promotes a malignant phenotype in breast cancer through angiogenic factor secretion

https://doi.org/10.18632/oncotarget.12286

Yu Jin Lee, Kyeong Jin Shin, Soo-Ah Park, Kyeong Su Park, Seorim Park, Kyun Heo, Young-Kyo Seo, Dong-Young Noh, Sung Ho Ryu,  and Pann-Ghill Suh
70898-70911
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

NKp44 and NKp30 splice variant profiles in decidua and tumor tissues: a comparative viewpoint

NKp44 and NKp30 splice variant profiles in decidua and tumor tissues: a comparative viewpoint

https://doi.org/10.18632/oncotarget.12292

Avishai Shemesh, Aleksandra Kugel, Naama Steiner, Michal Yezersky, Dan Tirosh, Avishay Edri, Omri Teltsh, Benyamin Rosental, Eyal Sheiner, Eitan Rubin, Kerry S. Campbell,  and Angel Porgador
70912-70923
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

DACT2 silencing by promoter CpG methylation disrupts its regulation of epithelial-to-mesenchymal transition and cytoskeleton reorganization in breast cancer cells

DACT2 silencing by promoter CpG methylation disrupts its regulation of epithelial-to-mesenchymal transition and cytoskeleton reorganization in breast cancer cells

https://doi.org/10.18632/oncotarget.12341

Tingxiu Xiang, Yichao Fan, Chunhong Li, Lili Li, Ying Ying, Junhao Mu, Weiyan Peng, Yixiao Feng, Michael Oberst, Kathleen Kelly, Guosheng Ren,  and Qian Tao
70924-70935
Abstract  |  PDF  |  HTML  |  Order a Reprint

Smoking-associated lung cancer prevention by blockade of the beta-adrenergic receptor-mediated insulin-like growth factor receptor activation

Smoking-associated lung cancer prevention by blockade of the beta-adrenergic receptor-mediated insulin-like growth factor receptor activation

https://doi.org/10.18632/oncotarget.12342

Hye-Young Min, Hye-Jin Boo, Ho Jin Lee, Hyun-Ji Jang, Hye Jeong Yun, Su Jung Hwang, John Kendal Smith, Hyo-Jong Lee,  and Ho-Young Lee
70936-70947
Abstract  |  PDF  |  HTML  |  Order a Reprint

Clinical Research Papers

Blood baseline neutrophil count predicts bevacizumab efficacy in glioblastoma

Blood baseline neutrophil count predicts bevacizumab efficacy in glioblastoma

https://doi.org/10.18632/oncotarget.10898

Aurélie Bertaut, Caroline Truntzer, Rachid Madkouri, Coureche Guillaume Kaderbhai, Valentin Derangère, Julie Vincent, Bruno Chauffert, Marie Hélene Aubriot-Lorton, Wahlid Farah, Klaus Luc Mourier, Romain Boidot,  and Francois Ghiringhelli
70948-70958
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Bone marrow involvement identifies a subgroup of advanced Ewing sarcoma patients with fatal outcome irrespective of therapy in contrast to curable patients with multiple bone metastases but unaffected marrow

Bone marrow involvement identifies a subgroup of advanced Ewing sarcoma patients with fatal outcome irrespective of therapy in contrast to curable patients with multiple bone metastases but unaffected marrow

https://doi.org/10.18632/oncotarget.10938

Uwe Thiel, Angela Wawer, Irene von Luettichau, Hans-Ulrich Bender, Franziska Blaeschke, Thomas G.P. Grunewald, Marc Steinborn, Barbara Röper, Halvard Bonig, Thomas Klingebiel, Peter Bader, Ewa Koscielniak, Michael Paulussen, Uta Dirksen, Heribert Juergens, Hans-Jochem Kolb,  and Stefan E.G. Burdach
70959-70968
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Concurrent paclitaxel/cisplatin chemoradiotherapy with or without consolidation chemotherapy in high-risk early-stage cervical cancer patients following radical hysterectomy: preliminary results of a phase III randomized study

Concurrent paclitaxel/cisplatin chemoradiotherapy with or without consolidation chemotherapy in high-risk early-stage cervical cancer patients following radical hysterectomy: preliminary results of a phase III randomized study

https://doi.org/10.18632/oncotarget.10450

Hongqin Zhao, Lili Li, Huafang Su, Baochai Lin, Xuebang Zhang, Shengliu Xue, Zhenghua Fei, Lihao Zhao, Qintuo Pan, Xiance Jin,  and Congying Xie
70969-70978
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Two-dimensional versus three-dimensional laparoscopy in surgical efficacy: a systematic review and meta-analysis

Two-dimensional versus three-dimensional laparoscopy in surgical efficacy: a systematic review and meta-analysis

https://doi.org/10.18632/oncotarget.10916

Ji Cheng, Jinbo Gao, Xiaoming Shuai, Guobin Wang,  and Kaixiong Tao
70979-70990
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Hormone receptor status may impact the survival benefit of surgery in stage IV breast cancer: a population-based study

Hormone receptor status may impact the survival benefit of surgery in stage IV breast cancer: a population-based study

https://doi.org/10.18632/oncotarget.11235

Yinuo Tan, Xiaofen Li, Haiyan Chen, Yeting Hu, Mengjie Jiang, Jianfei Fu, Ying Yuan,  and Kefeng Ding
70991-71000
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Reviews

TH9 cell differentiation, transcriptional control and function in inflammation, autoimmune diseases and cancer

TH9 cell differentiation, transcriptional control and function in inflammation, autoimmune diseases and cancer

https://doi.org/10.18632/oncotarget.11681

Yan Li, Qing Yu, Zhengguo Zhang, Jian Wang, Simin Li, Jiangyuan Zhang,  and Guangwei Liu
71001-71012
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Cell-free DNA and next-generation sequencing in the service of personalized medicine for lung cancer

Cell-free DNA and next-generation sequencing in the service of personalized medicine for lung cancer

https://doi.org/10.18632/oncotarget.11717

Catherine W. Bennett, Guy Berchem, Yeoun Jin Kim,  and Victoria El-Khoury
71013-71035
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Combination treatment including targeted therapy for advanced hepatocellular carcinoma

Combination treatment including targeted therapy for advanced hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.11954

Jianzhen Lin, Liangcai Wu, Xue Bai, Yuan Xie, Anqiang Wang, Haohai Zhang, Xiaobo Yang, Xueshuai Wan, Xin Lu, Xinting Sang,  and Haitao Zhao
71036-71051
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Review: Traumatic brain injury and hyperglycemia, a potentially modifiable risk factor

Review: Traumatic brain injury and hyperglycemia, a potentially modifiable risk factor

https://doi.org/10.18632/oncotarget.11958

Jia Shi, Bo Dong, Yumin Mao, Wei Guan, Jiachao Cao, Rongxing Zhu,  and Suinuan Wang
71052-71061
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