Oncotarget

Vol 7, No 42

October 18, 2016

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About The Cover

The cover for issue 42 of Oncotarget features Supplemental Figure 2, 'Immunohistochemistry', from Darb-Esfahani, et al


Table of Contents

Priority Research Papers

Role of TP53 mutations in triple negative and HER2-positive breast cancer treated with neoadjuvant anthracycline/taxane-based chemotherapy

Role of TP53 mutations in triple negative and HER2-positive breast cancer treated with neoadjuvant anthracycline/taxane-based chemotherapy

https://doi.org/10.18632/oncotarget.11891

Silvia Darb-Esfahani, Carsten Denkert, Albrecht Stenzinger, Christoph Salat, Bruno Sinn, Christian Schem, Volker Endris, Peter Klare, Wolfgang Schmitt, Jens-Uwe Blohmer, Wilko Weichert, Markus Möbs, Hans Tesch, Sherko Kümmel, Peter Sinn, Christian Jackisch, Manfred Dietel, Toralf Reimer, Sherene Loi, Michael Untch, Gunter von Minckwitz, Valentina Nekljudova,  and Sibylle Loibl
67686-67698
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Research Papers: Gerotarget (Focus on Aging)

ATF6α regulates morphological changes associated with senescence in human fibroblasts

ATF6α regulates morphological changes associated with senescence in human fibroblasts

https://doi.org/10.18632/oncotarget.11505

Clémentine Druelle, Claire Drullion, Julie Deslé, Nathalie Martin, Laure Saas, Johanna Cormenier, Nicolas Malaquin, Ludovic Huot, Christian Slomianny, Fatima Bouali, Chantal Vercamer, David Hot, Albin Pourtier, Eric Chevet, Corinne Abbadie,  and Olivier Pluquet
67699-67715
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Quercetin ameliorates Aβ toxicity in Drosophila AD model by modulating cell cycle-related protein expression

Quercetin ameliorates Aβ toxicity in Drosophila AD model by modulating cell cycle-related protein expression

https://doi.org/10.18632/oncotarget.11963

Yan Kong, Ke Li, Tingting Fu, Chao Wan, Dongdong Zhang, Hang Song, Yao Zhang, Na Liu, Zhenji Gan,  and Liudi Yuan
67716-67731
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Long-term monitoring of Ca2+ dynamics in C. elegans pharynx: an in vivo energy balance sensor

Long-term monitoring of Ca2+ dynamics in C. elegans pharynx: an in vivo energy balance sensor

https://doi.org/10.18632/oncotarget.12177

Pilar Alvarez-Illera, Adolfo Sanchez-Blanco, Silvia Lopez-Burillo, Rosalba I. Fonteriz, Javier Alvarez,  and Mayte Montero
67732-67747
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Research Papers: Pathology

Elevated serum concentrations of HE4 as a novel biomarker of disease severity and renal fibrosis in kidney disease

Elevated serum concentrations of HE4 as a novel biomarker of disease severity and renal fibrosis in kidney disease

https://doi.org/10.18632/oncotarget.11682

Jianxin Wan, Yanhong Wang, Gaorong Cai, Jianbo Liang, Caifeng Yue, Fen Wang, Junli Song, Jianfeng Wang, Min Liu, Jinmei Luo,  and Laisheng Li
67748-67759
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Heme oxygenase-1 deficiency exacerbates angiotensin II-induced aortic aneurysm in mice

Heme oxygenase-1 deficiency exacerbates angiotensin II-induced aortic aneurysm in mice

https://doi.org/10.18632/oncotarget.11917

Yen-Chun Ho, Meng-Ling Wu, Pei-Yu Gung, Chung-Huang Chen, Cheng-Chin Kuo,  and Shaw-Fang Yet
67760-67776
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Interferon-stimulated gene 15 in hepatitis B-related liver diseases

Interferon-stimulated gene 15 in hepatitis B-related liver diseases

https://doi.org/10.18632/oncotarget.11955

Nghiem Xuan Hoan, Hoang Van Tong, Dao Phuong Giang, Nguyen Linh Toan, Christian G. Meyer, C.-Thomas Bock, Peter G. Kremsner, Le Huu Song,  and Thirumalaisamy P. Velavan
67777-67787
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Genetic variants in vitamin D signaling pathways and risk of gestational diabetes mellitus

Genetic variants in vitamin D signaling pathways and risk of gestational diabetes mellitus

https://doi.org/10.18632/oncotarget.11984

Aiwu Shi, Juan Wen, Guangquan Liu, Heng Liu, Ziyi Fu, Jing Zhou, Yao Zhu, Yaoqiu Liu, Xirong Guo,  and Jianguo Xu
67788-67795
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Adipocyte miR-200b/a/429 ablation in mice leads to high-fat-diet-induced obesity

Adipocyte miR-200b/a/429 ablation in mice leads to high-fat-diet-induced obesity

https://doi.org/10.18632/oncotarget.12080

Cong Tao, Hongyan Ren, Pan Xu, Jia Cheng, Sujuan Huang, Rong Zhou, Yulian Mu, Shulin Yang, Desheng Qi, Yanfang Wang,  and Kui Li
67796-67807
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High fat diet exacerbates Alzheimer’s disease-related pathology in APPswe/PS1 mice

High fat diet exacerbates Alzheimer’s disease-related pathology in APPswe/PS1 mice

https://doi.org/10.18632/oncotarget.12179

Peter Thériault, Ayman ElAli,  and Serge Rivest
67808-67827
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Renal denervation attenuates aldosterone expression and associated cardiovascular pathophysiology in angiotensin II-induced hypertension

Renal denervation attenuates aldosterone expression and associated cardiovascular pathophysiology in angiotensin II-induced hypertension

https://doi.org/10.18632/oncotarget.12182

Mo-Na Hong, Xiao-Dong Li, Dong-Rui Chen, Cheng-Chao Ruan, Jian-Zhong Xu, Jing Chen, Yong-Jie Wu, Yu Ma, Ding-Liang Zhu,  and Ping-Jin Gao
67828-67840
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β-catenin interaction with NHERF1 and RASSF1A methylation in metastatic colorectal cancer patients

β-catenin interaction with NHERF1 and RASSF1A methylation in metastatic colorectal cancer patients

https://doi.org/10.18632/oncotarget.12280

Laura Schirosi, Annalisa Mazzotta, Giuseppina Opinto, Rosamaria Pinto, Giusi Graziano, Stefania Tommasi, Livia Fucci, Giovanni Simone,  and Anita Mangia
67841-67850
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Analysis of the association of single nucleotide polymorphisms of interleukin-23 receptor (IL-23R) and inflammatory bowel disease in a Chinese Han cohort

Analysis of the association of single nucleotide polymorphisms of interleukin-23 receptor (IL-23R) and inflammatory bowel disease in a Chinese Han cohort

https://doi.org/10.18632/oncotarget.12296

Zhong-Kai Lu, Zhi-Rong Chen, Jun-Yi Zhu, Ya Xu,  and Xian Hua
67851-67856
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Overexpression of caveolin-1 attenuates brain edema by inhibiting tight junction degradation

Overexpression of caveolin-1 attenuates brain edema by inhibiting tight junction degradation

https://doi.org/10.18632/oncotarget.12346

Kang-Ho Choi, Hyung-Seok Kim, Man-Seok Park, Eun-Bin Lee, Jung-Kil Lee, Joon-Tae Kim, Ja-Hae Kim, Min-Cheol Lee, Hong-Joon Lee,  and Ki-Hyun Cho
67857-67867
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Research Papers: Immunology

Biomarkers to detect membranous nephropathy in Chinese patients

Biomarkers to detect membranous nephropathy in Chinese patients

https://doi.org/10.18632/oncotarget.12014

Li Lin, Wei Ming Wang, Xiao Xia Pan, Jing Xu, Chen Ni Gao, Wen Zhang, Hong Ren, Jing Yuan Xie, Pin Yan Shen, Yao Wen Xu, Li Yan Ni,  and Nan Chen
67868-67879
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Sodium fluoride induces apoptosis in cultured splenic lymphocytes from mice

Sodium fluoride induces apoptosis in cultured splenic lymphocytes from mice

https://doi.org/10.18632/oncotarget.12081

Huidan Deng, Ping Kuang, Hengmin Cui, Lian Chen, Jing Fang, Zhicai Zuo, Junliang Deng, Xun Wang,  and Ling Zhao
67880-67900
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B lymphocytes as direct antigen-presenting cells for anti-tumor DNA vaccines

B lymphocytes as direct antigen-presenting cells for anti-tumor DNA vaccines

https://doi.org/10.18632/oncotarget.12178

Viswa Teja Colluru,  and Douglas G. McNeel
67901-67918
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Research Papers: Autophagy and Cell Death

Genetic inhibition of autophagy promotes p53 loss-of-heterozygosity and tumorigenesis

Genetic inhibition of autophagy promotes p53 loss-of-heterozygosity and tumorigenesis

https://doi.org/10.18632/oncotarget.12084

Eunmyong Lee, Yongjie Wei, Zhongju Zou, Kathryn Tucker, Dinesh Rakheja, Beth Levine,  and James F. Amatruda
67919-67933
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Research Papers: Chromosome

Chromatin determinants of the inner-centromere rely on replication factors with functions that impart cohesion

Chromatin determinants of the inner-centromere rely on replication factors with functions that impart cohesion

https://doi.org/10.18632/oncotarget.11982

Takuya Abe, Ryotaro Kawasumi, Hiroshi Arakawa, Tetsuya Hori, Katsuhiko Shirahige, Ana Losada, Tatsuo Fukagawa,  and Dana Branzei
67934-67947
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Research Papers

Analysis of overall survival in a large multiethnic cohort reveals absolute neutrophil count of 1,100 as a novel prognostic cutoff in African Americans

Analysis of overall survival in a large multiethnic cohort reveals absolute neutrophil count of 1,100 as a novel prognostic cutoff in African Americans

https://doi.org/10.18632/oncotarget.8996

Ioannis Mantzaris, Yiting Yu, Pavlos Msaouel, Anthony P. Lam, Murali Janakiram, Ellen W. Friedman, Ulrich Steidl,  and Amit K. Verma
67948-67955
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Modeling anti-IL-6 therapy using breast cancer patient-derived xenografts

Modeling anti-IL-6 therapy using breast cancer patient-derived xenografts

https://doi.org/10.18632/oncotarget.11815

Beatriz Morancho, Mariano Zacarías-Fluck, Antonio Esgueva, Cristina Bernadó-Morales, Serena Di Cosimo, Aleix Prat, Javier Cortés, Joaquín Arribas,  and Isabel T. Rubio
67956-67965
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Human cytomegalovirus encoded chemokine receptor US28 activates the HIF-1α/PKM2 axis in glioblastoma cells

Human cytomegalovirus encoded chemokine receptor US28 activates the HIF-1α/PKM2 axis in glioblastoma cells

https://doi.org/10.18632/oncotarget.11817

Raymond H. de Wit, Azra Mujić-Delić, Jeffrey R. van Senten, Alberto Fraile-Ramos, Marco Siderius,  and Martine J. Smit
67966-67985
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Identification of a new class of WNT1 inhibitor: Cancer cells migration, G-quadruplex stabilization and target validation

Identification of a new class of WNT1 inhibitor: Cancer cells migration, G-quadruplex stabilization and target validation

https://doi.org/10.18632/oncotarget.6622

Lien-Cheng Chang, Tsung-Chih Chen, Shiag-Jiun Chen, Chun-Liang Chen, Chia-Chung Lee, Shih-Hsiung Wu, Yun Yen, Hsu-Shan Huang,  and Jing-Jer Lin
67986-68001
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Association between 8q24 (rs13281615 and rs6983267) polymorphism and breast cancer susceptibility: a meta-analysis involving 117,355 subjects

Association between 8q24 (rs13281615 and rs6983267) polymorphism and breast cancer susceptibility: a meta-analysis involving 117,355 subjects

https://doi.org/10.18632/oncotarget.12009

Yafei Zhang, Xianling Zeng, Hongwei Lu, Hong Ji, Enfa Zhao,  and Yiming Li
68002-68011
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A gene expression signature of retinoblastoma loss-of-function is a predictive biomarker of resistance to palbociclib in breast cancer cell lines and is prognostic in patients with ER positive early breast cancer

A gene expression signature of retinoblastoma loss-of-function is a predictive biomarker of resistance to palbociclib in breast cancer cell lines and is prognostic in patients with ER positive early breast cancer

https://doi.org/10.18632/oncotarget.12010

Luca Malorni, Silvano Piazza, Yari Ciani, Cristina Guarducci, Martina Bonechi, Chiara Biagioni, Christopher D. Hart, Roberto Verardo, Angelo Di Leo,  and Ilenia Migliaccio
68012-68022
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Colony-forming unit cell (CFU-C) assays at diagnosis: CFU-G/M cluster predicts overall survival in myelodysplastic syndrome patients independently of IPSS-R

Colony-forming unit cell (CFU-C) assays at diagnosis: CFU-G/M cluster predicts overall survival in myelodysplastic syndrome patients independently of IPSS-R

https://doi.org/10.18632/oncotarget.12105

Bing Li, Jinqin Liu, Shiqiang Qu, Robert Peter Gale, Zhen Song, Ruixian Xing, Junxia Liu, Yansong Ren, Zefeng Xu, Tiejun Qin, Yue Zhang, Liwei Fang, Hongli Zhang, Lijuan Pan, Naibo Hu, Wenyu Cai, Peihong Zhang, Gang Huang,  and Zhijian Xiao
68023-68032
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Ovarian low and high grade serous carcinomas: hidden divergent features in the tumor microenvironment

Ovarian low and high grade serous carcinomas: hidden divergent features in the tumor microenvironment

https://doi.org/10.18632/oncotarget.10797

Alessandra Ciucci, Gian Franco Zannoni, Marianna Buttarelli, Enrica Martinelli, Floriana Mascilini, Marco Petrillo, Gabriella Ferrandina, Giovanni Scambia,  and Daniela Gallo
68033-68043
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Peroxiredoxin I is important for cancer-cell survival in Ras-induced hepatic tumorigenesis

Peroxiredoxin I is important for cancer-cell survival in Ras-induced hepatic tumorigenesis

https://doi.org/10.18632/oncotarget.11172

Bing Han, Hye-Jun Shin, In Seon Bak, Yesol Bak, Ye-Lin Jeong, Taeho Kwon, Young-Ho Park, Hu-Nan Sun, Cheol-Hee Kim,  and Dae-Yeul Yu
68044-68056
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Neuropilin-1 is a receptor for extracellular miRNA and AGO2/miRNA complexes and mediates the internalization of miRNAs that modulate cell function

Neuropilin-1 is a receptor for extracellular miRNA and AGO2/miRNA complexes and mediates the internalization of miRNAs that modulate cell function

https://doi.org/10.18632/oncotarget.10929

Gerald J. Prud'homme, Yelena Glinka, Zsuzsanna Lichner,  and George M. Yousef
68057-68071
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Intra-tumoral delivery of functional ID4 protein via PCL/maltodextrin nano-particle inhibits prostate cancer growth

Intra-tumoral delivery of functional ID4 protein via PCL/maltodextrin nano-particle inhibits prostate cancer growth

https://doi.org/10.18632/oncotarget.10953

Maxwell Korang-Yeboah, Divya Patel, Derrick Morton, Pankaj Sharma, Yamini Gorantla, Jugal Joshi, Perri Nagappan, Ravi Pallaniappan,  and Jaideep Chaudhary
68072-68085
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MYSM1/miR-150/FLT3 inhibits B1a cell proliferation

MYSM1/miR-150/FLT3 inhibits B1a cell proliferation

https://doi.org/10.18632/oncotarget.11738

Xiao-Xia Jiang, Yu Liu, Hong Li, Yaping Gao, Rong Mu, Jianping Guo, Jing Zhang, Yan-Mei Yang, Fengjun Xiao, Bing Liu, Changyong Wang, Beifen Shen, Si-Yi Chen, Zhanguo Li,  and Guang Yang
68086-68096
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The identification of a novel role for BRCA1 in regulating RNA polymerase I transcription

The identification of a novel role for BRCA1 in regulating RNA polymerase I transcription

https://doi.org/10.18632/oncotarget.11770

Rebecca Johnston, Zenobia D’Costa, Swagat Ray, Julia Gorski, D. Paul Harkin, Paul Mullan,  and Konstantin I. Panov
68097-68110
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Extracellular domain shedding influences specific tumor uptake and organ distribution of the EGFR PET tracer 89Zr-imgatuzumab

Extracellular domain shedding influences specific tumor uptake and organ distribution of the EGFR PET tracer 89Zr-imgatuzumab

https://doi.org/10.18632/oncotarget.11827

Martin Pool, Arjan Kol, Marjolijn N. Lub-de Hooge, Christian A. Gerdes, Steven de Jong, Elisabeth G.E. de Vries,  and Anton G.T. Terwisscha van Scheltinga
68111-68121
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Thrombomodulin promotes focal adhesion kinase activation and contributes to angiogenesis by binding to fibronectin

Thrombomodulin promotes focal adhesion kinase activation and contributes to angiogenesis by binding to fibronectin

https://doi.org/10.18632/oncotarget.11828

Yun-Yan Hsu, Guey-Yueh Shi, Kuan-Chieh Wang, Chih-Yuan Ma, Tsung-Lin Cheng,  and Hua-Lin Wu
68122-68139
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

IGFBP6 is a novel nasopharyngeal carcinoma prognostic biomarker

IGFBP6 is a novel nasopharyngeal carcinoma prognostic biomarker

https://doi.org/10.18632/oncotarget.11886

Qiuyan Chen, Siyuan Qin, Yang Liu, Minghuang Hong, Chao-Nan Qian, Evan T. Keller, Jian Zhang,  and Yi Lu
68140-68150
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Androgen receptor CAG and GGN repeat length variation contributes more to the tumorigenesis of osteosarcoma

Androgen receptor CAG and GGN repeat length variation contributes more to the tumorigenesis of osteosarcoma

https://doi.org/10.18632/oncotarget.11902

Yongxiang Shi, Weishan Chen, Qinghuai Li,  and Zhaoming Ye
68151-68155
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New HSP27 inhibitors efficiently suppress drug resistance development in cancer cells

New HSP27 inhibitors efficiently suppress drug resistance development in cancer cells

https://doi.org/10.18632/oncotarget.11905

Jörg C. Heinrich, Sainitin Donakonda, V. Joachim Haupt, Petra Lennig, Yixin Zhang,  and Michael Schroeder
68156-68169
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Diisopropylamine dichloroacetate enhances radiosensitization in esophageal squamous cell carcinoma by increasing mitochondria-derived reactive oxygen species levels

Diisopropylamine dichloroacetate enhances radiosensitization in esophageal squamous cell carcinoma by increasing mitochondria-derived reactive oxygen species levels

https://doi.org/10.18632/oncotarget.11906

Gaochao Dong, Qiang Chen, Feng Jiang, Decai Yu, Qixing Mao, Wenjie Xia, Run Shi, Jie Wang,  and Lin Xu
68170-68178
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Interferon-stimulated gene of 20 kDa protein (ISG20) degrades RNA of hepatitis B virus to impede the replication of HBV in vitro and in vivo

Interferon-stimulated gene of 20 kDa protein (ISG20) degrades RNA of hepatitis B virus to impede the replication of HBV in vitro and in vivo

https://doi.org/10.18632/oncotarget.11907

Chean Ring Leong, Kenji Funami, Hiroyuki Oshiumi, Deng Mengao, Hiromi Takaki, Misako Matsumoto, Hussein H. Aly, Koichi Watashi, Kazuaki Chayama,  and Tsukasa Seya
68179-68193
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The antiangiogenic effects of polyisoprenylated cysteinyl amide inhibitors in HUVEC, chick embryo and zebrafish is dependent on the polyisoprenyl moiety

The antiangiogenic effects of polyisoprenylated cysteinyl amide inhibitors in HUVEC, chick embryo and zebrafish is dependent on the polyisoprenyl moiety

https://doi.org/10.18632/oncotarget.11908

Augustine T. Nkembo, Elizabeth Ntantie, Olufisayo O. Salako, Felix Amissah, Rosemary A. Poku, Lekan M. Latinwo,  and Nazarius S. Lamango
68194-68205
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

TumorNext: A comprehensive tumor profiling assay that incorporates high resolution copy number analysis and germline status to improve testing accuracy

TumorNext: A comprehensive tumor profiling assay that incorporates high resolution copy number analysis and germline status to improve testing accuracy

https://doi.org/10.18632/oncotarget.11910

Phillip N. Gray, Huy Vuong, Pei Tsai, Hsaio-Mei Lu, Wenbo Mu, Vickie Hsuan, Jayne Hoo, Swati Shah, Lisa Uyeda, Susanne Fox, Harshil Patel, Mike Janicek, Sandra Brown, Lavinia Dobrea, Lawrence Wagman, Elizabeth Plimack, Ranee Mehra, Erica A. Golemis, Marijo Bilusic, Matthew Zibelman,  and Aaron Elliott
68206-68228
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Galectin-3 supports stemness in ovarian cancer stem cells by activation of the Notch1 intracellular domain

Galectin-3 supports stemness in ovarian cancer stem cells by activation of the Notch1 intracellular domain

https://doi.org/10.18632/oncotarget.11920

Hyeok Gu Kang, Da-Hyun Kim, Seok-Jun Kim, Yunhee Cho, Junghyun Jung, Wonhee Jang,  and Kyung-Hee Chun
68229-68241
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Quantitative proteomics reveals FLNC as a potential progression marker for the development of hepatocellular carcinoma

Quantitative proteomics reveals FLNC as a potential progression marker for the development of hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.11921

Yingzi Qi, Feng Xu, Lingsheng Chen, Yanchang Li, Zhongwei Xu, Yao Zhang, Wei Wei, Na Su, Tao Zhang, Fengxu Fan, Xing Wang, Xue Qin, Lingqiang Zhang, Yinkun Liu,  and Ping Xu
68242-68252
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Ex vivo miRNome analysis in Ptch1+/− cerebellum granule cells reveals a subset of miRNAs involved in radiation-induced medulloblastoma

Ex vivo miRNome analysis in Ptch1+/− cerebellum granule cells reveals a subset of miRNAs involved in radiation-induced medulloblastoma

https://doi.org/10.18632/oncotarget.11938

Barbara Tanno, Gabriele Babini, Simona Leonardi, Paola Giardullo, Ilaria De Stefano, Emanuela Pasquali, Andrea Ottolenghi, Michael J. Atkinson, Anna Saran,  and Mariateresa Mancuso
68253-68269
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Association mining of mutated cancer genes in different clinical stages across 11 cancer types

Association mining of mutated cancer genes in different clinical stages across 11 cancer types

https://doi.org/10.18632/oncotarget.11392

Wangxiong Hu, Xiaofen Li, Tingzhang Wang,  and Shu Zheng
68270-68277
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Phenotypic screening reveals TNFR2 as a promising target for cancer immunotherapy

Phenotypic screening reveals TNFR2 as a promising target for cancer immunotherapy

https://doi.org/10.18632/oncotarget.11943

Geoffrey S. Williams, Bina Mistry, Sandrine Guillard, Jane Coates Ulrichsen, Alan M. Sandercock, Jun Wang, Andrea González-Muñoz, Julie Parmentier, Chelsea Black, Jo Soden, Jim Freeth, Jelena Jovanović, Rebecca Leyland, Rafia S. Al-Lamki, Andrew J. Leishman, Steven J. Rust, Ross Stewart, Lutz Jermutus, John R. Bradley, Vahe Bedian, Viia Valge-Archer, Ralph Minter,  and Robert W. Wilkinson
68278-68291
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Activation of NLRP1 and NLRP3 inflammasomes contributed to cyclic stretch-induced pyroptosis and release of IL-1β in human periodontal ligament cells

Activation of NLRP1 and NLRP3 inflammasomes contributed to cyclic stretch-induced pyroptosis and release of IL-1β in human periodontal ligament cells

https://doi.org/10.18632/oncotarget.11944

Dan Zhao, Yaqin Wu, Jiabao Zhuang, Chun Xu,  and Fuqiang Zhang
68292-68302
Abstract  |  PDF  |  HTML  |  Order a Reprint

CD74 interacts with CD44 and enhances tumorigenesis and metastasis via RHOA-mediated cofilin phosphorylation in human breast cancer cells

CD74 interacts with CD44 and enhances tumorigenesis and metastasis via RHOA-mediated cofilin phosphorylation in human breast cancer cells

https://doi.org/10.18632/oncotarget.11945

Zhiyong Liu, Shuzhou Chu, Shun Yao, Yu Li, Songqing Fan, Xiaoyang Sun, Ling Su,  and Xiangguo Liu
68303-68313
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Propranolol induced G0/G1/S phase arrest and apoptosis in melanoma cells via AKT/MAPK pathway

Propranolol induced G0/G1/S phase arrest and apoptosis in melanoma cells via AKT/MAPK pathway

https://doi.org/10.18632/oncotarget.11599

Chengfang Zhou, Xiang Chen, Weiqi Zeng, Cong Peng, Gang Huang, Xian’an Li, Zhengxiao Ouyang, Yi Luo, Xuezheng Xu, Biaobo Xu, Weili Wang, Ruohui He, Xu Zhang, Liyang Zhang, Jie Liu, Todd C. Knepper, Yijing He,  and Howard L. McLeod
68314-68327
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

GOLPH3 overexpression correlates with poor response to neoadjuvant therapy and prognosis in locally advanced rectal cancer

GOLPH3 overexpression correlates with poor response to neoadjuvant therapy and prognosis in locally advanced rectal cancer

https://doi.org/10.18632/oncotarget.12008

Kunli Zhu, Qianqian Zhao, Jinbo Yue, Pengyue Shi, Hongjiang Yan, Xiaoqing Xu,  and Renben Wang
68328-68338
Abstract  |  PDF  |  HTML  |  Order a Reprint

Loss of long noncoding RNA FOXF1-AS1 regulates epithelial-mesenchymal transition, stemness and metastasis of non-small cell lung cancer cells

Loss of long noncoding RNA FOXF1-AS1 regulates epithelial-mesenchymal transition, stemness and metastasis of non-small cell lung cancer cells

https://doi.org/10.18632/oncotarget.11630

Liyun Miao, Zhen Huang, Zhang Zengli, Hui Li, Qiufang Chen, Chenyun Yao, Hourong Cai, Yonglong Xiao, Hongping Xia,  and Yongsheng Wang
68339-68349
Abstract  |  PDF  |  HTML  |  Order a Reprint

Recurrent mutations of MAPK pathway genes in multiple myeloma but not in amyloid light-chain amyloidosis

Recurrent mutations of MAPK pathway genes in multiple myeloma but not in amyloid light-chain amyloidosis

https://doi.org/10.18632/oncotarget.12029

Seok Jin Kim, Hyun-Tae Shin, Hae-Ock Lee, Nayoung K.D. Kim, Jae Won Yun, Jee Hyang Hwang, Kihyun Kim,  and Woong-Yang Park
68350-68359
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Two-stage induced differentiation of OCT4+/Nanog+ stem-like cells in lung adenocarcinoma

Two-stage induced differentiation of OCT4+/Nanog+ stem-like cells in lung adenocarcinoma

https://doi.org/10.18632/oncotarget.11721

Rong Li, Jinsu Huang, Meili Ma, Yuqing Lou, Yanwei Zhang, Lixia Wu, David W. Chang, Picheng Zhao, Qianggang Dong, Xifeng Wu,  and Baohui Han
68360-68370
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Oncogenic microRNA-4534 regulates PTEN pathway in prostate cancer

Oncogenic microRNA-4534 regulates PTEN pathway in prostate cancer

https://doi.org/10.18632/oncotarget.12031

Hannah Nip, Altaf A. Dar, Sharanjot Saini, Melissa Colden, Shahryari Varahram, Harshika Chowdhary, Soichiro Yamamura, Yozo Mitsui, Yuichiro Tanaka, Taku Kato, Yutaka Hashimoto, Marisa Shiina, Priyanka Kulkarni, Pritha Dasgupta, Mitsuho Imai-Sumida, Z. Laura Tabatabai, Kirsten Greene, Guoren Deng, Rajvir Dahiya,  and Shahana Majid
68371-68384
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

CATS (FAM64A) abnormal expression reduces clonogenicity of hematopoietic cells

CATS (FAM64A) abnormal expression reduces clonogenicity of hematopoietic cells

https://doi.org/10.18632/oncotarget.11724

Isabella Barbutti, Juliana M. Xavier-Ferrucio, João Agostinho Machado-Neto, Lauremilia Ricon, Fabiola Traina, Stefan K. Bohlander, Sara Teresinha Olalla Saad,  and Leticia Fröhlich Archangelo
68385-68396
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MicroRNA-140-5p targets insulin like growth factor 2 mRNA binding protein 1 (IGF2BP1) to suppress cervical cancer growth and metastasis

MicroRNA-140-5p targets insulin like growth factor 2 mRNA binding protein 1 (IGF2BP1) to suppress cervical cancer growth and metastasis

https://doi.org/10.18632/oncotarget.11722

Yanlin Su, Jie Xiong, Jinyue Hu, Xin Wei, Xuelian Zhang,  and Lijuan Rao
68397-68411
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Dual oxidase 2 and pancreatic adenocarcinoma: IFN-γ-mediated dual oxidase 2 overexpression results in H2O2-induced, ERK-associated up-regulation of HIF-1α and VEGF-A

Dual oxidase 2 and pancreatic adenocarcinoma: IFN-γ-mediated dual oxidase 2 overexpression results in H2O2-induced, ERK-associated up-regulation of HIF-1α and VEGF-A

https://doi.org/10.18632/oncotarget.12032

Yongzhong Wu, Jennifer L. Meitzler, Smitha Antony, Agnes Juhasz, Jiamo Lu, Guojian Jiang, Han Liu, Melinda Hollingshead, Diana C. Haines, Donna Butcher, Michaela S. Panter, Krishnendu Roy,  and James H. Doroshow
68412-68433
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A single-nucleotide polymorphism in MMP9 is associated with decreased risk of steroid-induced osteonecrosis of the femoral head

A single-nucleotide polymorphism in MMP9 is associated with decreased risk of steroid-induced osteonecrosis of the femoral head

https://doi.org/10.18632/oncotarget.12034

Jieli Du, Wanlin Liu, Tianbo Jin, Zhenqun Zhao, Rui Bai, Huiqin Xue, Junyu Chen, Mingqi Sun, Xiyang Zhang, Guoqiang Wang,  and Jianzhong Wang
68434-68441
Abstract  |  PDF  |  HTML  |  Order a Reprint

Comparison of outcomes of tyrosine kinase inhibitor in first- or second-line therapy for advanced non-small-cell lung cancer patients with sensitive EGFR mutations

Comparison of outcomes of tyrosine kinase inhibitor in first- or second-line therapy for advanced non-small-cell lung cancer patients with sensitive EGFR mutations

https://doi.org/10.18632/oncotarget.12035

Jianlin Xu, Xueyan Zhang, Haitang Yang, Guozheng Ding, Bo Jin, Yuqing Lou, Yanwei Zhang, Huimin Wang,  and Baohui Han
68442-68448
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Evolution of malignant plasmacytoma cell lines from K14E7 Fancd2−/− mouse long-term bone marrow cultures

Evolution of malignant plasmacytoma cell lines from K14E7 Fancd2−/− mouse long-term bone marrow cultures

https://doi.org/10.18632/oncotarget.12036

Xichen Zhang, Wen Hou, Michael W. Epperly, Lora Rigatti, Hong Wang, Darcy Franicola, Aranee Sivanathan,  and Joel S. Greenberger
68449-68472
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Binding of human recombinant mutant soluble ectodomain of FGFR2IIIc to c subtype of FGFRs: implications for anticancer activity

Binding of human recombinant mutant soluble ectodomain of FGFR2IIIc to c subtype of FGFRs: implications for anticancer activity

https://doi.org/10.18632/oncotarget.12067

Zhong Liu, Ge Liu, Guang-Lin Zhang, Jun Li, Yan-Qing He, Shu-Shu Zhang, Yi Wang, Wei-Yi He, Guo-Hua Cheng, Xuesong Yang, Jun Xu,  and Ju Wang
68473-68488
Abstract  |  PDF  |  HTML  |  Order a Reprint

RPN13/ADRM1 inhibitor reverses immunosuppression by myeloid-derived suppressor cells

RPN13/ADRM1 inhibitor reverses immunosuppression by myeloid-derived suppressor cells

https://doi.org/10.18632/oncotarget.12095

Ruey-Shyang Soong, Ravi K. Anchoori, Benjamin Yang, Andrew Yang, Ssu-Hsueh Tseng, Liangmei He, Ya-Chea Tsai, Chien-Fu Hung,  and Chien-Fu Hung
68489-68502
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Antigen-specific T cell Redirectors: a nanoparticle based approach for redirecting T cells

Antigen-specific T cell Redirectors: a nanoparticle based approach for redirecting T cells

https://doi.org/10.18632/oncotarget.11785

Christian Schütz, Juan Carlos Varela, Karlo Perica, Carl Haupt, Mathias Oelke,  and Jonathan P. Schneck
68503-68512
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

NK cell function is markedly impaired in patients with chronic lymphocytic leukaemia but is preserved in patients with small lymphocytic lymphoma

NK cell function is markedly impaired in patients with chronic lymphocytic leukaemia but is preserved in patients with small lymphocytic lymphoma

https://doi.org/10.18632/oncotarget.12097

Helen M. Parry, Tom Stevens, Ceri Oldreive, Bassier Zadran, Tina McSkeane, Zbigniew Rudzki, Shankara Paneesha, Caroline Chadwick, Tatjana Stankovic, Guy Pratt, Jianmin Zuo,  and Paul Moss
68513-68526
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Heparins that block VEGF-A-mediated von Willebrand factor fiber generation are potent inhibitors of hematogenous but not lymphatic metastasis

Heparins that block VEGF-A-mediated von Willebrand factor fiber generation are potent inhibitors of hematogenous but not lymphatic metastasis

https://doi.org/10.18632/oncotarget.11832

Lukas Goertz, Stefan Werner Schneider, Anna Desch, Frank Thomas Mayer, Julian Koett, Kai Nowak, Ioannis Karampinis, Michael K. Bohlmann, Viktor Umansky,  and Alexander Thomas Bauer
68527-68545
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Specific inhibition of p110α subunit of PI3K: putative therapeutic strategy for KRAS mutant colorectal cancers

Specific inhibition of p110α subunit of PI3K: putative therapeutic strategy for KRAS mutant colorectal cancers

https://doi.org/10.18632/oncotarget.11843

Maria Sofia Fernandes, Soraia Melo, Sérgia Velho, Patrícia Carneiro, Fátima Carneiro,  and Raquel Seruca
68546-68558
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A three-molecule score based on Notch pathway predicts poor prognosis in non-metastasis clear cell renal cell carcinoma

A three-molecule score based on Notch pathway predicts poor prognosis in non-metastasis clear cell renal cell carcinoma

https://doi.org/10.18632/oncotarget.11849

Zheng Liu, Qiang Fu, Hangcheng Fu, Zewei Wang, Le Xu, Huimin An, Yanfeng Li,  and Jiejie Xu
68559-68570
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Mebendazole and a non-steroidal anti-inflammatory combine to reduce tumor initiation in a colon cancer preclinical model

Mebendazole and a non-steroidal anti-inflammatory combine to reduce tumor initiation in a colon cancer preclinical model

https://doi.org/10.18632/oncotarget.11851

Tara Williamson, Ren-Yuan Bai, Verena Staedtke, David Huso,  and Gregory J. Riggins
68571-68584
Abstract  |  PDF  |  HTML  |  Order a Reprint

Low expression of miR-381 is a favorite prognosis factor and enhances the chemosensitivity of osteosarcoma

Low expression of miR-381 is a favorite prognosis factor and enhances the chemosensitivity of osteosarcoma

https://doi.org/10.18632/oncotarget.11861

Yunchao Li, Chunhua Zhao, Zhibin Yu, Jiarui Chen, Xiaoling She, Peiyao Li, Changhong Liu, Yan Zhang, Jianbo Feng, Haijuan Fu, Bing Wang, Lei Kuang, Lei Li, Guohua Lv,  and Minghua Wu
68585-68596
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Differential protein stability of EGFR mutants determines responsiveness to tyrosine kinase inhibitors

Differential protein stability of EGFR mutants determines responsiveness to tyrosine kinase inhibitors

https://doi.org/10.18632/oncotarget.11860

Paramita Ray, Yee Sun Tan, Vishal Somnay, Ranjit Mehta, Merna Sitto, Aarif Ahsan, Shyam Nyati, John P. Naughton, Alexander Bridges, Lili Zhao, Alnawaz Rehemtulla, Theodore S. Lawrence, Dipankar Ray,  and Mukesh K. Nyati
68597-68613
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Inhibition of nuclear factor-κB signaling suppresses Spint1-deletion-induced tumor susceptibility in the ApcMin/+ model

Inhibition of nuclear factor-κB signaling suppresses Spint1-deletion-induced tumor susceptibility in the ApcMin/+ model

https://doi.org/10.18632/oncotarget.11863

Makiko Kawaguchi, Koji Yamamoto, Ai Kanemaru, Hiroyuki Tanaka, Kazuo Umezawa, Tsuyoshi Fukushima,  and Hiroaki Kataoka
68614-68622
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

DCTPP1 attenuates the sensitivity of human gastric cancer cells to 5-fluorouracil by up-regulating MDR1 expression epigenetically

DCTPP1 attenuates the sensitivity of human gastric cancer cells to 5-fluorouracil by up-regulating MDR1 expression epigenetically

https://doi.org/10.18632/oncotarget.11864

Li-liang Xia, Ya-bin Tang, Fei-fei Song, Ling Xu, Ping Ji, Shu-jun Wang, Ji-min Zhu, Yong Zhang, Guo-ping Zhao, Ying Wang,  and Tao-tao Liu
68623-68637
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The somatic POLE P286R mutation defines a unique subclass of colorectal cancer featuring hypermutation, representing a potential genomic biomarker for immunotherapy

The somatic POLE P286R mutation defines a unique subclass of colorectal cancer featuring hypermutation, representing a potential genomic biomarker for immunotherapy

https://doi.org/10.18632/oncotarget.11862

Sung-Min Ahn, Adnan Ahmad Ansari, Jihun Kim, Deokhoon Kim, Sung-Min Chun, Jiyun Kim, Tae Won Kim, Inja Park, Chang-Sik Yu,  and Se Jin Jang
68638-68649
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Overexpression of LLT1 (OCIL, CLEC2D) on prostate cancer cells inhibits NK cell-mediated killing through LLT1-NKRP1A (CD161) interaction

Overexpression of LLT1 (OCIL, CLEC2D) on prostate cancer cells inhibits NK cell-mediated killing through LLT1-NKRP1A (CD161) interaction

https://doi.org/10.18632/oncotarget.11896

Stephen O. Mathew, Pankaj Chaudhary, Sheila B. Powers, Jamboor K. Vishwanatha,  and Porunelloor A. Mathew
68650-68661
Abstract  |  PDF  |  HTML  |  Order a Reprint

Pathological complete response after cisplatin neoadjuvant therapy is associated with the downregulation of DNA repair genes in BRCA1-associated triple-negative breast cancers

Pathological complete response after cisplatin neoadjuvant therapy is associated with the downregulation of DNA repair genes in BRCA1-associated triple-negative breast cancers

https://doi.org/10.18632/oncotarget.11900

Pawel Domagala, Jolanta Hybiak, Janusz Rys, Tomasz Byrski, Cezary Cybulski,  and Jan Lubinski
68662-68673
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Epigenetically regulated miR-145 suppresses colon cancer invasion and metastasis by targeting LASP1

Epigenetically regulated miR-145 suppresses colon cancer invasion and metastasis by targeting LASP1

https://doi.org/10.18632/oncotarget.11919

Wei Wang, Gang Ji, Xin Xiao, Xu Chen, Wei-Wei Qin, Fan Yang, Yu-Fang Li, Lin-Ni Fan, Wen-Jin Xi, Yi Huo, Wei-Hong Wen, An-Gang Yang,  and Tao Wang
68674-68687
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Constructing Bayesian networks by integrating gene expression and copy number data identifies NLGN4Y as a novel regulator of prostate cancer progression

Constructing Bayesian networks by integrating gene expression and copy number data identifies NLGN4Y as a novel regulator of prostate cancer progression

https://doi.org/10.18632/oncotarget.11925

Yixuan Gong, Li Wang, Uma Chippada-Venkata, Xudong Dai, William K. Oh,  and Jun Zhu
68688-68707
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Grifolin inhibits tumor cells adhesion and migration via suppressing interplay between PGC1α and Fra-1/LSF-MMP2/CD44 axes

Grifolin inhibits tumor cells adhesion and migration via suppressing interplay between PGC1α and Fra-1/LSF-MMP2/CD44 axes

https://doi.org/10.18632/oncotarget.11929

Xiangjian Luo, Namei Li, Juanfang Zhong, Zheqiong Tan, Ying Liu, Xin Dong, Can Cheng, Zhijie Xu, Hongde Li, Lifang Yang, Min Tang, Xinxian Weng, Wei Yi, Jikai Liu,  and Ya Cao
68708-68720
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Expression of a recombinant full-length LRP1B receptor in human non-small cell lung cancer cells confirms the postulated growth-suppressing function of this large LDL receptor family member

Expression of a recombinant full-length LRP1B receptor in human non-small cell lung cancer cells confirms the postulated growth-suppressing function of this large LDL receptor family member

https://doi.org/10.18632/oncotarget.11897

Arno G. Beer, Christoph Zenzmaier, Michael Schreinlechner, Jenny Haas, Martin F. Dietrich, Joachim Herz,  and Peter Marschang
68721-68733
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Molecular alterations and tumor suppressive function of the DUSP22 (Dual Specificity Phosphatase 22) gene in peripheral T-cell lymphoma subtypes

Molecular alterations and tumor suppressive function of the DUSP22 (Dual Specificity Phosphatase 22) gene in peripheral T-cell lymphoma subtypes

https://doi.org/10.18632/oncotarget.11930

Pierre Mélard, Yamina Idrissi, Laetitia Andrique, Sandrine Poglio, Martina Prochazkova-Carlotti, Sabine Berhouet, Cécile Boucher, Elodie Laharanne, Edith Chevret, Anne Pham-Ledard, Andréa Carla De Souza Góes, Véronique Guyonnet-Duperat, Alice Bibeyran, François Moreau-Gaudry, Béatrice Vergier, Marie Beylot-Barry, Jean-Philippe Merlio,  and David Cappellen
68734-68748
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Exclusive inhibition of PI3K/Akt/mTOR signaling is not sufficient to prevent PDGF-mediated effects on glycolysis and proliferation in colorectal cancer

Exclusive inhibition of PI3K/Akt/mTOR signaling is not sufficient to prevent PDGF-mediated effects on glycolysis and proliferation in colorectal cancer

https://doi.org/10.18632/oncotarget.11899

Romana Moench, Tanja Grimmig, Vinicius Kannen, Sudipta Tripathi, Marc Faber, Eva-Maria Moll, Anil Chandraker, Reinhard Lissner, Christoph-Thomas Germer, Ana Maria Waaga-Gasser,  and Martin Gasser
68749-68767
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Epigenetic therapy potential of suberoylanilide hydroxamic acid on invasive human non-small cell lung cancer cells

Epigenetic therapy potential of suberoylanilide hydroxamic acid on invasive human non-small cell lung cancer cells

https://doi.org/10.18632/oncotarget.11967

Shirong Zhang, Kan Wu, Jianguo Feng, Zhibing Wu, Qinghua Deng, Chao Guo, Bing Xia, Jing Zhang, Haixiu Huang, Lucheng Zhu, Ke Zhang, Binghui Shen, Xufeng Chen,  and Shenglin Ma
68768-68780
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

CB2 cannabinoid receptor activation promotes colon cancer progression via AKT/GSK3β signaling pathway

CB2 cannabinoid receptor activation promotes colon cancer progression via AKT/GSK3β signaling pathway

https://doi.org/10.18632/oncotarget.11968

Esther Martínez-Martínez, Asunción Martín-Ruíz, Paloma Martín, Virginia Calvo, Mariano Provencio,  and José M. García
68781-68791
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

FOXC2 augments tumor propagation and metastasis in osteosarcoma

FOXC2 augments tumor propagation and metastasis in osteosarcoma

https://doi.org/10.18632/oncotarget.11990

Maricel C. Gozo, Dongyu Jia, Paul-Joseph Aspuria, Dong-Joo Cheon, Naoyuki Miura, Ann E. Walts, Beth Y. Karlan,  and Sandra Orsulic
68792-68802
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A highly invasive subpopulation of MDA-MB-231 breast cancer cells shows accelerated growth, differential chemoresistance, features of apocrine tumors and reduced tumorigenicity in vivo

A highly invasive subpopulation of MDA-MB-231 breast cancer cells shows accelerated growth, differential chemoresistance, features of apocrine tumors and reduced tumorigenicity in vivo

https://doi.org/10.18632/oncotarget.11931

Adriana Amaro, Giovanna Angelini, Valentina Mirisola, Alessia Isabella Esposito, Daniele Reverberi, Serena Matis, Massimo Maffei, Walter Giaretti, Maurizio Viale, Rosaria Gangemi, Laura Emionite, Simonetta Astigiano, Michele Cilli, Beatrice E. Bachmeier, Peter H. Killian, Adriana Albini,  and Ulrich Pfeffer
68803-68820
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Altered expression of A20 gene in peripheral blood mononuclear cells is associated with the progression of chronic hepatitis B virus infection

Altered expression of A20 gene in peripheral blood mononuclear cells is associated with the progression of chronic hepatitis B virus infection

https://doi.org/10.18632/oncotarget.11993

Yu-Chen Fan, Yuan-Yuan Zhang, Yan-Yan Sun, Na Wang, Xiao-Yan Xiao,  and Kai Wang
68821-68832
Abstract  |  PDF  |  HTML  |  Order a Reprint

Identification of a structurally novel BTK mutation that drives ibrutinib resistance in CLL

Identification of a structurally novel BTK mutation that drives ibrutinib resistance in CLL

https://doi.org/10.18632/oncotarget.11932

Shruti Sharma, Natalie Galanina, Ailin Guo, Jimmy Lee, Sabah Kadri, Charles Van Slambrouck, Bradley Long, Weige Wang, Mei Ming, Larissa V. Furtado, Jeremy P. Segal, Wendy Stock, Girish Venkataraman, Wei-Jen Tang, Pin Lu,  and Yue Lynn Wang
68833-68841
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Heterozygous mutation of cysteine528 in XPO1 is sufficient for resistance to selective inhibitors of nuclear export

Heterozygous mutation of cysteine528 in XPO1 is sufficient for resistance to selective inhibitors of nuclear export

https://doi.org/10.18632/oncotarget.11995

Jasper Edgar Neggers, Els Vanstreels, Erkan Baloglu, Sharon Shacham, Yosef Landesman,  and Dirk Daelemans
68842-68850
Abstract  |  PDF  |  HTML  |  Order a Reprint

Comprehensive landscape of subtype-specific coding and non-coding RNA transcripts in breast cancer

Comprehensive landscape of subtype-specific coding and non-coding RNA transcripts in breast cancer

https://doi.org/10.18632/oncotarget.11998

Trung Nghia Vu, Setia Pramana, Stefano Calza, Chen Suo, Donghwan Lee,  and Yudi Pawitan
68851-68863
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Cyanidin-3-o-glucoside directly binds to ERα36 and inhibits EGFR-positive triple-negative breast cancer

Cyanidin-3-o-glucoside directly binds to ERα36 and inhibits EGFR-positive triple-negative breast cancer

https://doi.org/10.18632/oncotarget.12025

Li Wang, Haifeng Li, Shiping Yang, Wenqiang Ma, Mei Liu, Shichao Guo, Jun Zhan, Hongquan Zhang, Suk Ying Tsang, Ziding Zhang, Zhaoyi Wang, Xiru Li, Yang-Dong Guo,  and Xiangdong Li
68864-68882
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

GADD45β, an anti-tumor gene, inhibits avian leukosis virus subgroup J replication in chickens

GADD45β, an anti-tumor gene, inhibits avian leukosis virus subgroup J replication in chickens

https://doi.org/10.18632/oncotarget.12027

Xinheng Zhang, Zhuanqiang Yan, Xinjian Li, Wencheng Lin, Zhenkai Dai, Yiming Yan, Piaopiao Lu, Weiguo Chen, Huanmin Zhang, Feng Chen, Jingyun Ma,  and Qingmei Xie
68883-68893
Abstract  |  PDF  |  HTML  |  Order a Reprint

Diagnostic value of circulating miR-21: An update meta-analysis in various cancers and validation in endometrial cancer

Diagnostic value of circulating miR-21: An update meta-analysis in various cancers and validation in endometrial cancer

https://doi.org/10.18632/oncotarget.12028

Yun Gao, Meiyu Dai, Haihua Liu, Wangjiao He, Shengzhang Lin, Tianzhu Yuan, Hong Chen,  and Shengming Dai
68894-68908
Abstract  |  PDF  |  HTML  |  Order a Reprint

Differential expression analysis for individual cancer samples based on robust within-sample relative gene expression orderings across multiple profiling platforms

Differential expression analysis for individual cancer samples based on robust within-sample relative gene expression orderings across multiple profiling platforms

https://doi.org/10.18632/oncotarget.11996

Qingzhou Guan, Rou Chen, Haidan Yan, Hao Cai, You Guo, Mengyao Li, Xiangyu Li, Mengsha Tong, Lu Ao, Hongdong Li, Guini Hong,  and Zheng Guo
68909-68920
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Sorting nexin 9 (SNX9) is not essential for development and auditory function in mice

Sorting nexin 9 (SNX9) is not essential for development and auditory function in mice

https://doi.org/10.18632/oncotarget.12040

Chengcheng Liu, Xiaoyan Zhai, Haibo Du, Yujie Cao, Huiren Cao, Yanfei Wang, Xiao Yu, Jiangang Gao,  and Zhigang Xu
68921-68932
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

BIM deletion polymorphisms in Hispanic patients with non-small cell lung cancer carriers of EGFR mutations

BIM deletion polymorphisms in Hispanic patients with non-small cell lung cancer carriers of EGFR mutations

https://doi.org/10.18632/oncotarget.12112

Andrés F. Cardona, Leonardo Rojas, Beatriz Wills, Oscar Arrieta, Hernán Carranza, Carlos Vargas, Jorge Otero, Luis Corrales-Rodriguez, Claudio Martín, Noemí Reguart, Pilar Archila, July Rodríguez, Mauricio Cuello, Carlos Ortíz, Sandra Franco, Christian Rolfo, Rafael Rosell,  and on behalf of the CLICaP
68933-68942
Abstract  |  PDF  |  HTML  |  Order a Reprint

Eosinophil percentage elevation as a prognostic factor for overall survival in patients with metastatic renal cell carcinoma treated with tyrosine kinase inhibitor

Eosinophil percentage elevation as a prognostic factor for overall survival in patients with metastatic renal cell carcinoma treated with tyrosine kinase inhibitor

https://doi.org/10.18632/oncotarget.12126

Hong-Kai Wang, Fang-Nin Wan, Wei-Jie Gu, Yao Zhu, Bo Dai, Guo-Hai Shi, Hai-Liang Zhang,  and Ding-Wei Ye
68943-68953
Abstract  |  PDF  |  HTML  |  Order a Reprint

Association between tumor-stroma ratio and prognosis in solid tumor patients: a systematic review and meta-analysis

Association between tumor-stroma ratio and prognosis in solid tumor patients: a systematic review and meta-analysis

https://doi.org/10.18632/oncotarget.12135

Jiayuan Wu, Caixia Liang, Manyu Chen,  and Wenmei Su
68954-68965
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

WW45, a Gli1 binding protein, negatively regulated Hedgehog signaling in lung cancer

WW45, a Gli1 binding protein, negatively regulated Hedgehog signaling in lung cancer

https://doi.org/10.18632/oncotarget.12155

Xuebing Li, Xuexia Zhou, Yaguang Fan, Yalong Zhang, Lingling Zu, Feng Yao,  and Qinghua Zhou
68966-68975
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Hsp60 exerts a tumor suppressor function by inducing cell differentiation and inhibiting invasion in hepatocellular carcinoma

Hsp60 exerts a tumor suppressor function by inducing cell differentiation and inhibiting invasion in hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.12185

Jing Zhang, Xingchun Zhou, Hulin Chang, Xiaojun Huang, Xu Guo, Xiaohong Du, Siyuan Tian, Lexiao Wang, Yinghua Lyv, Peng Yuan,  and Jinliang Xing
68976-68989
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Mast cells promote melanoma colonization of lungs

Mast cells promote melanoma colonization of lungs

https://doi.org/10.18632/oncotarget.11837

Helena Öhrvik, Mirjana Grujic, Ida Waern, Ann-Marie Gustafson, Nancy Ernst, Axel Roers, Karin Hartmann,  and Gunnar Pejler
68990-69001
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Clinical Research Papers

A network meta-analysis: the overall and progression-free survival of glioma patients treated by different chemotherapeutic interventions combined with radiation therapy (RT)

A network meta-analysis: the overall and progression-free survival of glioma patients treated by different chemotherapeutic interventions combined with radiation therapy (RT)

https://doi.org/10.18632/oncotarget.10763

Ling Qi, Lijuan Ding, Shuran Wang, Yue Zhong, Donghai Zhao, Ling Gao, Weiyao Wang, Peng Lv, Ye Xu,  and Shudong Wang
69002-69013
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Samarium-153-EDTMP (Quadramet®) with or without vaccine in metastatic castration-resistant prostate cancer: A randomized Phase 2 trial

Samarium-153-EDTMP (Quadramet®) with or without vaccine in metastatic castration-resistant prostate cancer: A randomized Phase 2 trial

https://doi.org/10.18632/oncotarget.10883

Christopher R. Heery, Ravi A. Madan, Mark N. Stein, Walter M. Stadler, Robert S. DiPaola, Myrna Rauckhorst, Seth M. Steinberg, Jennifer L. Marté, Clara C. Chen, Italia Grenga, Renee N. Donahue, Caroline Jochems, William L. Dahut, Jeffrey Schlom,  and James L. Gulley
69014-69023
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Increased hepatic FDG uptake on PET/CT in hepatic sinusoidal obstructive syndrome

Increased hepatic FDG uptake on PET/CT in hepatic sinusoidal obstructive syndrome

https://doi.org/10.18632/oncotarget.11816

Honsoul Kim, Song-Ee Baek, Jieun Mo­­on, Yun Ho Roh, Narae Lee,  and Arthur Cho
69024-69031
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Predictive value of homocysteine for depression after acute coronary syndrome

Predictive value of homocysteine for depression after acute coronary syndrome

https://doi.org/10.18632/oncotarget.11966

Hee Ju Kang, Robert Stewart, Kyung Yeol Bae, Sung Wan Kim, Il Seon Shin, Hyuno Kang, Won Jin Moon, Young Joon Hong, Youngkeun Ahn, Myung Ho Jeong, Jin Sang Yoon,  and Jae Min Kim
69032-69040
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Comparison of the efficacy between concurrent chemoradiotherapy with or without adjuvant chemotherapy and intensity-modulated radiotherapy alone for stage II nasopharyngeal carcinoma

Comparison of the efficacy between concurrent chemoradiotherapy with or without adjuvant chemotherapy and intensity-modulated radiotherapy alone for stage II nasopharyngeal carcinoma

https://doi.org/10.18632/oncotarget.11978

Kai-Hua Chen, Xiao-Dong Zhu, Ling Li, Song Qu, Zhen-Qiang Liang, Xia Liang, Xin-Bin Pan, Zhong-Guo Liang,  and Yan-Ming Jiang
69041-69050
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The role of cerebral blood flow gradient in peritumoral edema for differentiation of glioblastomas from solitary metastatic lesions

The role of cerebral blood flow gradient in peritumoral edema for differentiation of glioblastomas from solitary metastatic lesions

https://doi.org/10.18632/oncotarget.12053

Lin Lin, Yunjing Xue, Qing Duan, Bin Sun, Hailong Lin, Xinming Huang,  and Xiaodan Chen
69051-69059
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Reviews

HER-2 inhibition in gastric and colorectal cancers: tangible achievements, novel acquisitions and future perspectives

HER-2 inhibition in gastric and colorectal cancers: tangible achievements, novel acquisitions and future perspectives

https://doi.org/10.18632/oncotarget.11264

Valentina Fanotto, Elena Ongaro, Karim Rihawi, Antonio Avallone, Nicola Silvestris, Lorenzo Fornaro, Enrico Vasile, Lorenzo Antonuzzo, Francesco Leone, Gerardo Rosati, Francesco Giuliani, Roberto Bordonaro, Mario Scartozzi, Giovanna De Maglio, Francesca V. Negri, Gianpiero Fasola,  and Giuseppe Aprile
69060-69074
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The non-canonical functions of the heme oxygenases

The non-canonical functions of the heme oxygenases

https://doi.org/10.18632/oncotarget.11923

Luca Vanella, Ignazio Barbagallo, Daniele Tibullo, Stefano Forte, Agata Zappalà,  and Giovanni Li Volti
69075-69086
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Prognostic and clinicopathological value of Gli-1 expression in gastric cancer: A meta-analysis

Prognostic and clinicopathological value of Gli-1 expression in gastric cancer: A meta-analysis

https://doi.org/10.18632/oncotarget.12011

Li Lu, Menglin Wu, Feixiang Zhao, Weihua Fu, Weidong Li, Xue Li,  and Tong Liu
69087-69096
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