Oncotarget

Vol 7, No 35

August 30, 2016

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About The Cover

The cover for issue 35 of Oncotarget features Figure 6 (Effects of BMP9 and VEGFR2 blockade on CNV) from Ntumba, et al.

Table of Contents

Priority Research Papers

Immortalization of human AE pre-leukemia cells by hTERT allows leukemic transformation

Immortalization of human AE pre-leukemia cells by hTERT allows leukemic transformation

https://doi.org/10.18632/oncotarget.11093

Shan Lin, Junping Wei, Mark Wunderlich, Fu-Sheng Chou,  and James C. Mulloy
55939-55950
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Research Papers: Gerotarget (Focus on Aging)

GDF11 administration does not extend lifespan in a mouse model of premature aging

GDF11 administration does not extend lifespan in a mouse model of premature aging

https://doi.org/10.18632/oncotarget.11096

Sandra Freitas-Rodríguez, Francisco Rodríguez,  and Alicia R. Folgueras
55951-55956
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BMP9/ALK1 inhibits neovascularization in mouse models of age-related macular degeneration

BMP9/ALK1 inhibits neovascularization in mouse models of age-related macular degeneration

https://doi.org/10.18632/oncotarget.11182

Kalonji Ntumba, Naoufal Akla, S. Paul Oh, Anne Eichmann,  and Bruno Larrivée
55957-55969
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Interview with Dr. Bruno Larrivee  |  Order a Reprint

Biological relevance of fatty acyl heterogeneity to the neural membrane dynamics of Rhesus macaques during normative aging

Biological relevance of fatty acyl heterogeneity to the neural membrane dynamics of Rhesus macaques during normative aging

https://doi.org/10.18632/oncotarget.11190

Sin Man Lam, Gek Huey Chua, Xiao-Jiang Li, Bing Su,  and Guanghou Shui
55970-55989
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Research Papers: Pathology

α2-adrenoreceptor modulated FAK pathway induced by dexmedetomidine attenuates pulmonary microvascular hyper-permeability following kidney injury

α2-adrenoreceptor modulated FAK pathway induced by dexmedetomidine attenuates pulmonary microvascular hyper-permeability following kidney injury

https://doi.org/10.18632/oncotarget.10809

Qian Chen, Bin Yi, Jianbo Ma, Jiaoling Ning, Lingzhi Wu, Daqing Ma, Kaizhi Lu,  and Jianteng Gu
55990-56001
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Porcine reproductive and respiratory syndrome virus triggers mitochondrial fission and mitophagy to attenuate apoptosis

Porcine reproductive and respiratory syndrome virus triggers mitochondrial fission and mitophagy to attenuate apoptosis

https://doi.org/10.18632/oncotarget.10817

Shuaifeng Li, Jiaxing Wang, Ao Zhou, Faheem Ahmed Khan, Lin Hu,  and Shujun Zhang
56002-56012
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Multiple myeloma-derived Jagged ligands increases autocrine and paracrine interleukin-6 expression in bone marrow niche

Multiple myeloma-derived Jagged ligands increases autocrine and paracrine interleukin-6 expression in bone marrow niche

https://doi.org/10.18632/oncotarget.10820

Michela Colombo, Serena Galletti, Gaetano Bulfamante, Monica Falleni, Delfina Tosi, Katia Todoerti, Elisa Lazzari, Leslie A. Crews, Catriona H.M. Jamieson, Sara Ravaioli, Francesco Baccianti, Silvia Garavelli, Natalia Platonova, Antonino Neri,  and Raffaella Chiaramonte
56013-56029
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Potential implications of Apolipoprotein E in early brain injury after experimental subarachnoid hemorrhage: Involvement in the modulation of blood-brain barrier integrity

Potential implications of Apolipoprotein E in early brain injury after experimental subarachnoid hemorrhage: Involvement in the modulation of blood-brain barrier integrity

https://doi.org/10.18632/oncotarget.10821

Jinwei Pang, Yue Wu, Jianhua Peng, Ping Yang, Li Kuai, Xinghu Qin, Fang Cao, Xiaochuan Sun, Ligang Chen, Michael P. Vitek,  and Yong Jiang
56030-56044
Abstract  |  PDF  |  HTML  |  Order a Reprint

Resveratrol counteracts lipopolysaccharide-induced depressive-like behaviors via enhanced hippocampal neurogenesis

Resveratrol counteracts lipopolysaccharide-induced depressive-like behaviors via enhanced hippocampal neurogenesis

https://doi.org/10.18632/oncotarget.11178

Liang Liu, Qin Zhang, Yulong Cai, Dayu Sun, Xie He, Lian Wang, Dan Yu, Xin Li, Xiaoyi Xiong, Haiwei Xu, Qingwu Yang,  and Xiaotang Fan
56045-56059
Abstract  |  PDF  |  HTML  |  Order a Reprint

Overexpression of complement component C5a accelerates the development of atherosclerosis in ApoE-knockout mice

Overexpression of complement component C5a accelerates the development of atherosclerosis in ApoE-knockout mice

https://doi.org/10.18632/oncotarget.11180

Guipeng An, Bo Li, Xiaoman Liu, Mingxiang Zhang, Fei Gao, Yuxia Zhao, Fengshuang An, Yun Zhang,  and Cheng Zhang
56060-56070
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Butyrate alleviates high fat diet-induced obesity through activation of adiponectin-mediated pathway and stimulation of mitochondrial function in the skeletal muscle of mice

Butyrate alleviates high fat diet-induced obesity through activation of adiponectin-mediated pathway and stimulation of mitochondrial function in the skeletal muscle of mice

https://doi.org/10.18632/oncotarget.11267

Jian Hong, Yimin Jia, Shifeng Pan, Longfi Jia, Huifang Li, Zhenqiang Han, Demin Cai,  and Ruqian Zhao
56071-56082
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The HERC2 ubiquitin ligase is essential for embryonic development and regulates motor coordination

The HERC2 ubiquitin ligase is essential for embryonic development and regulates motor coordination

https://doi.org/10.18632/oncotarget.11270

Monica Cubillos-Rojas, Taiane Schneider, Ouadah Hadjebi, Leonardo Pedrazza, Jarbas Rodrigues de Oliveira, Francina Langa, Jean-Louis Guénet, Joan Duran, Josep Maria de Anta, Soledad Alcántara, Rocio Ruiz, Eva María Pérez-Villegas, Francisco J. Aguilar-Montilla, Ángel M. Carrión, Jose Angel Armengol, Emma Baple, Andrew H. Crosby, Ramon Bartrons, Francesc Ventura,  and Jose Luis Rosa
56083-56106
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Research Papers: Immunology

HBV suppresses expression of MICA/B on hepatoma cells through up-regulation of transcription factors GATA2 and GATA3 to escape from NK cell surveillance

HBV suppresses expression of MICA/B on hepatoma cells through up-regulation of transcription factors GATA2 and GATA3 to escape from NK cell surveillance

https://doi.org/10.18632/oncotarget.11271

Yun Guan, Weiqun Li, Zhaohua Hou, Qiuju Han, Peixiang Lan, Jian Zhang, Zhigang Tian,  and Cai Zhang
56107-56119
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Research Papers: Neuroscience

Analysis of the influence of memory content of auditory stimuli on the memory content of EEG signal

Analysis of the influence of memory content of auditory stimuli on the memory content of EEG signal

https://doi.org/10.18632/oncotarget.11234

Hamidreza Namazi, Reza Khosrowabadi, Jamal Hussaini, Shaghayegh Habibi, Ali Akhavan Farid,  and Vladimir V. Kulish
56120-56128
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Research Papers

Besides an ITIM/SHP-1-dependent pathway, CD22 collaborates with Grb2 and plasma membrane calcium-ATPase in an ITIM/SHP-1-independent pathway of attenuation of Ca2+i signal in B cells

Besides an ITIM/SHP-1-dependent pathway, CD22 collaborates with Grb2 and plasma membrane calcium-ATPase in an ITIM/SHP-1-independent pathway of attenuation of Ca2+i signal in B cells

https://doi.org/10.18632/oncotarget.9794

Jie Chen, Hong Wang, Wei-Ping Xu, Si-Si Wei, Hui Joyce Li, Yun-Qing Mei, Yi-Gang Li,  and Yue-Peng Wang
56129-56146
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

OASIS 2: online application for survival analysis 2 with features for the analysis of maximal lifespan and healthspan in aging research

OASIS 2: online application for survival analysis 2 with features for the analysis of maximal lifespan and healthspan in aging research

https://doi.org/10.18632/oncotarget.11269

Seong Kyu Han, Dongyeop Lee, Heetak Lee, Donghyo Kim, Heehwa G. Son, Jae-Seong Yang, Seung-Jae V. Lee,  and Sanguk Kim
56147-56152
Abstract  |  PDF  |  HTML  |  Order a Reprint

Mechanism of BRG1 silencing in primary cancers

Mechanism of BRG1 silencing in primary cancers

https://doi.org/10.18632/oncotarget.10593

Stefanie B. Marquez-Vilendrer, Kenneth Thompson, Li Lu,  and David Reisman
56153-56169
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Memo interacts with c-Src to control Estrogen Receptor alpha sub-cellular localization

Memo interacts with c-Src to control Estrogen Receptor alpha sub-cellular localization

https://doi.org/10.18632/oncotarget.10856

Anna Frei, Gwen MacDonald, Ingrid Lund, Jan-Åke Gustafsson, Nancy E. Hynes,  and Ivan Nalvarte
56170-56182
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Targeting Zfp148 activates p53 and reduces tumor initiation in the gut

Targeting Zfp148 activates p53 and reduces tumor initiation in the gut

https://doi.org/10.18632/oncotarget.10899

Anna Nilton, Volkan I. Sayin, Zhiyuan V. Zou, Sama I. Sayin, Cecilia Bondjers, Nadia Gul, Pia Agren, Per Fogelstrand, Ola Nilsson, Martin O. Bergo,  and Per Lindahl
56183-56192
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Overexpressed LAPTM4B-35 is a risk factor for cancer recurrence and poor prognosis in non-small-cell lung cancer

Overexpressed LAPTM4B-35 is a risk factor for cancer recurrence and poor prognosis in non-small-cell lung cancer

https://doi.org/10.18632/oncotarget.10907

Fanming Kong, Fangfang Gao, Jun Chen, Yiyu Sun, Ying Zhang, Honggen Liu, Xiaojiang Li, PeiYing Yang, Rongxiu Zheng, Geli Liu,  and Yingjie Jia
56193-56199
Abstract  |  PDF  |  HTML  |  Order a Reprint

MicroRNA-564 is downregulated in glioblastoma and inhibited proliferation and invasion of glioblastoma cells by targeting TGF-β1

MicroRNA-564 is downregulated in glioblastoma and inhibited proliferation and invasion of glioblastoma cells by targeting TGF-β1

https://doi.org/10.18632/oncotarget.8987

Chunming Jiang, Fang Shen, Jianmin Du, Zhaoyang Hu, Xiaoli Li, Jin Su, Xiaohua Wang,  and Xianmei Huang
56200-56208
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The lncRNA MALAT1 is a novel biomarker for gastric cancer metastasis

The lncRNA MALAT1 is a novel biomarker for gastric cancer metastasis

https://doi.org/10.18632/oncotarget.10941

Hongwei Xia, Qingjuan Chen, Ying Chen, Xiaojun Ge, Weibing Leng, Qiulin Tang, Ming Ren, Liang Chen, Dandan Yuan, Yucheng Zhang, Ming Liu, Qiyong Gong,  and Feng Bi
56209-56218
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Novel anti-CD3 chimeric antigen receptor targeting of aggressive T cell malignancies

Novel anti-CD3 chimeric antigen receptor targeting of aggressive T cell malignancies

https://doi.org/10.18632/oncotarget.11019

Kevin H. Chen, Masayuki Wada, Amelia E. Firor, Kevin G. Pinz, Alexander Jares, Hua Liu, Huda Salman, Marc Golightly, Fengshuo Lan, Xun Jiang,  and Yupo Ma
56219-56232
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Expression of PD-1 on CD4+ T cells in peripheral blood associates with poor clinical outcome in non-small cell lung cancer

Expression of PD-1 on CD4+ T cells in peripheral blood associates with poor clinical outcome in non-small cell lung cancer

https://doi.org/10.18632/oncotarget.9316

Hong Zheng, Xin Liu, Jianhong Zhang, Shawn J. Rice, Matthias Wagman, Yaxian Kong, Liuluan Zhu, Junjia Zhu, Monika Joshi,  and Chandra P. Belani
56233-56240
Abstract  |  PDF  |  HTML  |  Order a Reprint

The photosensitizer verteporfin has light-independent anti-leukemic activity for Ph-positive acute lymphoblastic leukemia and synergistically works with dasatinib

The photosensitizer verteporfin has light-independent anti-leukemic activity for Ph-positive acute lymphoblastic leukemia and synergistically works with dasatinib

https://doi.org/10.18632/oncotarget.11025

Takanobu Morishita, Fumihiko Hayakawa, Keiki Sugimoto, Mizuho Iwase, Hideyuki Yamamoto, Daiki Hirano, Yuki Kojima, Naoto Imoto, Tomoki Naoe,  and Hitoshi Kiyoi
56241-56252
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Smac mimetic LCL161 overcomes protective ER stress induced by obatoclax, synergistically causing cell death in multiple myeloma

Smac mimetic LCL161 overcomes protective ER stress induced by obatoclax, synergistically causing cell death in multiple myeloma

https://doi.org/10.18632/oncotarget.11028

Vijay Ramakrishnan, Marcus Gomez, Vivek Prasad, Teresa Kimlinger, Utkarsh Painuly, Bedabrata Mukhopadhyay, Jessica Haug, Lintao Bi, S. Vincent Rajkumar,  and Shaji Kumar
56253-56265
Abstract  |  PDF  |  HTML  |  Order a Reprint

Loss of MYC and E-box3 binding contributes to defective MYC-mediated transcriptional suppression of human MC-let-7a-1~let-7d in glioblastoma

Loss of MYC and E-box3 binding contributes to defective MYC-mediated transcriptional suppression of human MC-let-7a-1~let-7d in glioblastoma

https://doi.org/10.18632/oncotarget.10517

Zifeng Wang, Sheng Lin, Ji Zhang, Zhenhua Xu, Yu Xiang, Hong Yao, Lei Ge, Dan Xie, Hsiang-fu Kung, Gang Lu, Wai Sang Poon, Quentin Liu,  and Marie Chia-mi Lin
56266-56278
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Procoagulant and immunogenic properties of melanoma exosomes, microvesicles and apoptotic vesicles

Procoagulant and immunogenic properties of melanoma exosomes, microvesicles and apoptotic vesicles

https://doi.org/10.18632/oncotarget.10783

Morad-Rémy Muhsin-Sharafaldine, Sarah C. Saunderson, Amy C. Dunn, James M. Faed, Torsten Kleffmann,  and Alexander D. McLellan
56279-56294
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Gasdermin B expression predicts poor clinical outcome in HER2-positive breast cancer

Gasdermin B expression predicts poor clinical outcome in HER2-positive breast cancer

https://doi.org/10.18632/oncotarget.10787

Marta Hergueta-Redondo, David Sarrio, Ángela Molina-Crespo, Rocío Vicario, Cristina Bernadó-Morales, Lidia Martínez, Alejandro Rojo-Sebastián, Jordi Serra-Musach, Alba Mota, Ángel Martínez-Ramírez, Maria Ángeles Castilla, Antonio González-Martin, Sonia Pernas, Amparo Cano, Javier Cortes, Paolo G. Nuciforo, Vicente Peg, José Palacios, Miguel Ángel Pujana, Joaquín Arribas,  and Gema Moreno-Bueno
56295-56308
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Nuclear IKKα mediates microRNA-7/-103/107/21 inductions to downregulate maspin expression in response to HBx overexpression

Nuclear IKKα mediates microRNA-7/-103/107/21 inductions to downregulate maspin expression in response to HBx overexpression

https://doi.org/10.18632/oncotarget.10462

Wen-Shu Chen, Liang-Chih Liu, Chia-Jui Yen, Yun-Ju Chen, Jhen-Yu Chen, Chien-Yi Ho, Shu-Hui Liu, Ching-Chow Chen,  and Wei-Chien Huang
56309-56323
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Microenvironment mediated alterations to metabolic pathways confer increased chemo-resistance in CD133+ tumor initiating cells

Microenvironment mediated alterations to metabolic pathways confer increased chemo-resistance in CD133+ tumor initiating cells

https://doi.org/10.18632/oncotarget.10838

Alice Nomura, Patricia Dauer, Vineet Gupta, Olivia McGinn, Nivedita Arora, Kaustav Majumdar, Charles Uhlrich III, Joseph Dalluge, Vikas Dudeja, Ashok Saluja,  and Sulagna Banerjee
56324-56337
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

EZH2-mediated Puma gene repression regulates non-small cell lung cancer cell proliferation and cisplatin-induced apoptosis

EZH2-mediated Puma gene repression regulates non-small cell lung cancer cell proliferation and cisplatin-induced apoptosis

https://doi.org/10.18632/oncotarget.10841

Haidan Liu, Wei Li, Xinfang Yu, Feng Gao, Zhi Duan, Xiaolong Ma, Shiming Tan, Yunchang Yuan, Lijun Liu, Jian Wang, Xinmin Zhou,  and Yifeng Yang
56338-56354
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

TAM receptors Tyro3 and Mer as novel targets in colorectal cancer

TAM receptors Tyro3 and Mer as novel targets in colorectal cancer

https://doi.org/10.18632/oncotarget.10889

Robin Schmitz, Aida Freire Valls, Rosario Yerbes, Sophie von Richter, Christoph Kahlert, Sonja Loges, Jürgen Weitz, Martin Schneider, Carmen Ruiz de Almodovar, Alexis Ulrich,  and Thomas Schmidt
56355-56370
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Combining GRP78 suppression and MK2206-induced Akt inhibition decreases doxorubicin-induced P-glycoprotein expression and mitigates chemoresistance in human osteosarcoma

Combining GRP78 suppression and MK2206-induced Akt inhibition decreases doxorubicin-induced P-glycoprotein expression and mitigates chemoresistance in human osteosarcoma

https://doi.org/10.18632/oncotarget.10890

Yuan-Zheng Xia, Lei Yang, Gui-Min Xue, Chao Zhang, Chao Guo, Yan-Wei Yang, Shan-Shan Li, Lu-Yong Zhang, Qing-Long Guo,  and Ling-Yi Kong
56371-56382
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Construction and analysis of dysregulated lncRNA-associated ceRNA network identified novel lncRNA biomarkers for early diagnosis of human pancreatic cancer

Construction and analysis of dysregulated lncRNA-associated ceRNA network identified novel lncRNA biomarkers for early diagnosis of human pancreatic cancer

https://doi.org/10.18632/oncotarget.10891

Meng Zhou, Zhiyong Diao, Xiaolong Yue, Yang Chen, Hengqiang Zhao, Liang Cheng,  and Jie Sun
56383-56394
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Intratumoral heterogeneity of the therapeutical response to gemcitabine and metformin

Intratumoral heterogeneity of the therapeutical response to gemcitabine and metformin

https://doi.org/10.18632/oncotarget.10892

Dietmar Zechner, Florian Bürtin, Ann-Christin Albert, Xianbin Zhang, Simone Kumstel, Maria Schönrogge, Josefine Graffunder, Hao-Yu Shih, Sarah Müller, Tobias Radecke, Robert Jaster,  and Brigitte Vollmar
56395-56407
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Inhibition of the colony-stimulating-factor-1 receptor affects the resistance of lung cancer cells to cisplatin

Inhibition of the colony-stimulating-factor-1 receptor affects the resistance of lung cancer cells to cisplatin

https://doi.org/10.18632/oncotarget.10895

Harvey I. Pass, Carmencita Lavilla, Claudia Canino, Chandra Goparaju, Jordan Preiss, Samrah Noreen, Giovanni Blandino,  and Mario Cioce
56408-56421
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

C-Myc functions as a competing endogenous RNA in acute promyelocytic leukemia

C-Myc functions as a competing endogenous RNA in acute promyelocytic leukemia

https://doi.org/10.18632/oncotarget.10896

Ye Ding, Ze-chuan Wang, Yi Zheng, Zheng Hu, Yang Li, Dong-feng Luo,  and Shao-yuan Wang
56422-56430
Abstract  |  PDF  |  HTML  |  Order a Reprint

DICER governs characteristics of glioma stem cells and the resulting tumors in xenograft mouse models of glioblastoma

DICER governs characteristics of glioma stem cells and the resulting tumors in xenograft mouse models of glioblastoma

https://doi.org/10.18632/oncotarget.10570

Sheila Mansouri, Sanjay Singh, Amir Alamsahebpour, Kelly Burrell, Mira Li, Merve Karabork, Can Ekinci, Elizabeth Koch, Ihsan Solaroglu, Jeffery T. Chang, Bradly Wouters, Kenneth Aldape,  and Gelareh Zadeh
56431-56446
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Significant impact of amount of PCR input templates on various PCR-based DNA methylation analysis and countermeasure

Significant impact of amount of PCR input templates on various PCR-based DNA methylation analysis and countermeasure

https://doi.org/10.18632/oncotarget.10906

Zhaojun Liu, Jing Zhou, Liankun Gu,  and Dajun Deng
56447-56455
Abstract  |  PDF  |  HTML  |  Order a Reprint

Repurposing phenformin for the targeting of glioma stem cells and the treatment of glioblastoma

Repurposing phenformin for the targeting of glioma stem cells and the treatment of glioblastoma

https://doi.org/10.18632/oncotarget.10919

Wei Jiang, Susan Finniss, Simona Cazacu, Cunli Xiang, Ziv Brodie, Tom Mikkelsen, Laila Poisson, David B. Shackelford,  and Chaya Brodie
56456-56470
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

[64Cu]XYIMSR-06: A dual-motif CAIX ligand for PET imaging of clear cell renal cell carcinoma

[64Cu]XYIMSR-06: A dual-motif CAIX ligand for PET imaging of clear cell renal cell carcinoma

https://doi.org/10.18632/oncotarget.10602

Il Minn, Soo Min Koo, Hye Soo Lee, Mary Brummet, Steven P. Rowe, Michael A. Gorin, Polina Sysa-Shah, William D. Lewis, Hye-Hyun Ahn, Yuchuan Wang, Sangeeta Ray Banerjee, Ronnie C. Mease, Sridhar Nimmagadda, Mohamad E. Allaf, Martin G. Pomper,  and Xing Yang
56471-56479
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Identification of genetic variants predictive of early onset pancreatic cancer through a population science analysis of functional genomic datasets

Identification of genetic variants predictive of early onset pancreatic cancer through a population science analysis of functional genomic datasets

https://doi.org/10.18632/oncotarget.10924

Jinyun Chen, Xifeng Wu, Yujing Huang, Wei Chen, Randall E. Brand, Ann M. Killary, Subrata Sen,  and Marsha L. Frazier
56480-56490
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Clinical benefit of a precision medicine based approach for guiding treatment of refractory cancers

Clinical benefit of a precision medicine based approach for guiding treatment of refractory cancers

https://doi.org/10.18632/oncotarget.10606

Milan Radovich, Patrick J. Kiel, Stacy M. Nance, Erin E. Niland, Megan E. Parsley, Meagan E. Ferguson, Guanglong Jiang, Natraj R. Ammakkanavar, Lawrence H. Einhorn, Liang Cheng, Mehdi Nassiri, Darrell D. Davidson, Daniel A. Rushing, Patrick J. Loehrer, Roberto Pili, Nasser Hanna, J. Thomas Callaghan, Todd C. Skaar, Paul R. Helft, Safi Shahda, Bert H. O’Neil,  and Bryan P. Schneider
56491-56500
Abstract  |  PDF  |  HTML  |  Order a Reprint

Association of the GLB1 rs4678680 genetic variant with risk of HBV-related hepatocellular carcinoma

Association of the GLB1 rs4678680 genetic variant with risk of HBV-related hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.10963

Wen-Tao Wang, Ziqiang Li, Meng Shi, Hui Zhu, Xiangyu Xiong, Jinhua Shang, Jibing Liu, Mujian Teng,  and Ming Yang
56501-56507
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The in vitro and vivo anti-tumor effects and molecular mechanisms of suberoylanilide hydroxamic acid (SAHA) and MG132 on the aggressive phenotypes of gastric cancer cells

The in vitro and vivo anti-tumor effects and molecular mechanisms of suberoylanilide hydroxamic acid (SAHA) and MG132 on the aggressive phenotypes of gastric cancer cells

https://doi.org/10.18632/oncotarget.10643

Hang Lu, Xue-feng Yang, Xiao-qing Tian, Shou-long Tang, Lian-qian Li, Shuang Zhao,  and Hua-chuan Zheng
56508-56525
Abstract  |  PDF  |  HTML  |  Order a Reprint

The prognostic value of CSCs biomarker CD133 in NSCLC: a meta-analysis

The prognostic value of CSCs biomarker CD133 in NSCLC: a meta-analysis

https://doi.org/10.18632/oncotarget.10964

Engeng Chen, Zhiru Zeng, Bingjun Bai, Jing Zhu,  and Zhangfa Song
56526-56539
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

XIAP RING domain mediates miR-4295 expression and subsequently inhibiting p63α protein translation and promoting transformation of bladder epithelial cells

XIAP RING domain mediates miR-4295 expression and subsequently inhibiting p63α protein translation and promoting transformation of bladder epithelial cells

https://doi.org/10.18632/oncotarget.10645

Honglei Jin, Jiheng Xu, Xirui Guo, Haishan Huang, Jingxia Li, Minggang Peng, Junlan Zhu, Zhongxian Tian, Xue-Ru Wu, Moon-Shong Tang,  and Chuanshu Huang
56540-56557
Abstract  |  PDF  |  HTML  |  Order a Reprint

Pregnane X-receptor promotes stem cell-mediated colon cancer relapse

Pregnane X-receptor promotes stem cell-mediated colon cancer relapse

https://doi.org/10.18632/oncotarget.10646

Chris Planque, Fatemeh Rajabi, Fanny Grillet, Pascal Finetti, François Bertucci, Meritxell Gironella, Juan José Lozano, Bertrand Beucher, Julie Giraud, Véronique Garambois, Charles Vincent, Daniel Brown, Ludovic Caillo, Jovana Kantar, André Pelegrin, Michel Prudhomme, Jérémie Ripoche, Jean François Bourgaux, Christophe Ginestier, Antoni Castells, Frédéric Hollande, Julie Pannequin,  and Jean Marc Pascussi
56558-56573
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Increased frequency of circulating Th22 cells in patients with B-cell non-Hodgkin’s lymphoma

Increased frequency of circulating Th22 cells in patients with B-cell non-Hodgkin’s lymphoma

https://doi.org/10.18632/oncotarget.10966

Ting Lu, Yan Liu, Shuang Yu, Congcong Yin, Peng Li, Jingjing Ye, Daoxin Ma,  and Chunyan Ji
56574-56583
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Lysosome-associated membrane glycoprotein 1 predicts fratricide amongst T cell receptor transgenic CD8+ T cells directed against tumor-associated antigens

Lysosome-associated membrane glycoprotein 1 predicts fratricide amongst T cell receptor transgenic CD8+ T cells directed against tumor-associated antigens

https://doi.org/10.18632/oncotarget.10647

Andreas Kirschner, Melanie Thiede, Franziska Blaeschke, Günther H.S. Richter, Julia S. Gerke, Michaela C. Baldauf, Thomas G.P. Grünewald, Dirk H. Busch, Stefan Burdach,  and Uwe Thiel
56584-56597
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Notch1 directly induced CD133 expression in human diffuse type gastric cancers

Notch1 directly induced CD133 expression in human diffuse type gastric cancers

https://doi.org/10.18632/oncotarget.10967

Hidetomo Konishi, Naoki Asano, Akira Imatani, Osamu Kimura, Yutaka Kondo, Xiaoyi Jin, Takeshi Kanno, Waku Hatta, Nobuyuki Ara, Kiyotaka Asanuma, Tomoyuki Koike,  and Tooru Shimosegawa
56598-56607
Abstract  |  PDF  |  HTML  |  Order a Reprint

Urban-rural disparity of overweight/obesity distribution and its potential trend with breast cancer among Chinese women

Urban-rural disparity of overweight/obesity distribution and its potential trend with breast cancer among Chinese women

https://doi.org/10.18632/oncotarget.10968

Ying Gao, Yubei Huang, Fengju Song, Hongji Dai, Peishan Wang, Haixin Li, Hong Zheng, Henglei Dong, Jiali Han, Yaogang Wang,  and Kexin Chen
56608-56618
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Fatal gastrointestinal toxicity with ipilimumab after BRAF/ MEK inhibitor combination in a melanoma patient achieving pathological complete response

Fatal gastrointestinal toxicity with ipilimumab after BRAF/ MEK inhibitor combination in a melanoma patient achieving pathological complete response

https://doi.org/10.18632/oncotarget.10651

Maria Gonzalez-Cao, Aram Boada, Cristina Teixidó, María Teresa Fernandez- Figueras, Clara Mayo, Francesc Tresserra, Jean Bustamante, Santiago Viteri, Enrique Puertas, Mariacarmela Santarpia, Aldo Riso, Feliciano Barron, Niki Karachaliou,  and Rafael Rosell
56619-56627
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

miR-199a-3p targets stemness-related and mitogenic signaling pathways to suppress the expansion and tumorigenic capabilities of prostate cancer stem cells

miR-199a-3p targets stemness-related and mitogenic signaling pathways to suppress the expansion and tumorigenic capabilities of prostate cancer stem cells

https://doi.org/10.18632/oncotarget.10652

Ruifang Liu, Can Liu, Dingxiao Zhang, Bigang Liu, Xin Chen, Kiera Rycaj, Collene Jeter, Tammy Calhoun-Davis, Yandong Li, Tao Yang, Junchen Wang,  and Dean G. Tang
56628-56642
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Decreased fucosylated PSA as a urinary marker for high Gleason score prostate cancer

Decreased fucosylated PSA as a urinary marker for high Gleason score prostate cancer

https://doi.org/10.18632/oncotarget.10987

Kazutoshi Fujita, Takuji Hayashi, Kyosuke Matsuzaki, Wataru Nakata, Mika Masuda, Atsunari Kawashima, Takeshi Ujike, Akira Nagahara, Mutsumi Tsuchiya, Yuka Kobayashi, Satoshi Nojima, Motohide Uemura, Eiichi Morii, Eiji Miyoshi,  and Norio Nonomura
56643-56649
Abstract  |  PDF  |  HTML  |  Order a Reprint

Guttiferone K suppresses cell motility and metastasis of hepatocellular carcinoma by restoring aberrantly reduced profilin 1

Guttiferone K suppresses cell motility and metastasis of hepatocellular carcinoma by restoring aberrantly reduced profilin 1

https://doi.org/10.18632/oncotarget.10992

Kaikai Shen, Zhichao Xi, Jianling Xie, Hua Wang, Chanlu Xie, C. Soon Lee, Paul Fahey, Qihan Dong,  and Hongxi Xu
56650-56663
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Met promotes the formation of double minute chromosomes induced by Sei-1 in NIH-3T3 murine fibroblasts

Met promotes the formation of double minute chromosomes induced by Sei-1 in NIH-3T3 murine fibroblasts

https://doi.org/10.18632/oncotarget.10994

Yantao Bao, Jia Liu, Jia You, Di Wu, Yang Yu, Chang Liu, Lei Wang, Fei Wang, Lu Xu, Liqun Wang, Nan Wang, Xing Tian, Falin Wang, Hongbin Liang, Yating Gao, Xiaobo Cui, Guohua Ji, Jing Bai, Jingcui Yu, Xiangning Meng, Yan Jin, Wenjing Sun, Xin-yuan Guan, Chunyu Zhang,  and Songbin Fu
56664-56675
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Next generation multi-scale biophysical characterization of high precision cancer particle radiotherapy using clinical proton, helium-, carbon- and oxygen ion beams

Next generation multi-scale biophysical characterization of high precision cancer particle radiotherapy using clinical proton, helium-, carbon- and oxygen ion beams

https://doi.org/10.18632/oncotarget.10996

Ivana Dokic, Andrea Mairani, Martin Niklas, Ferdinand Zimmermann, Naved Chaudhri, Damir Krunic, Thomas Tessonnier, Alfredo Ferrari, Katia Parodi, Oliver Jäkel, Jürgen Debus, Thomas Haberer,  and Amir Abdollahi
56676-56689
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Seven protective miRNA signatures for prognosis of cervical cancer

Seven protective miRNA signatures for prognosis of cervical cancer

https://doi.org/10.18632/oncotarget.10678

Bei Liu, Jin-feng Ding, Jian Luo, Li Lu, Fen Yang,  and Xiao-dong Tan
56690-56698
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Regulation of cellular quiescence by YAP/TAZ and Cyclin E1 in colon cancer cells: Implication in chemoresistance and cancer relapse

Regulation of cellular quiescence by YAP/TAZ and Cyclin E1 in colon cancer cells: Implication in chemoresistance and cancer relapse

https://doi.org/10.18632/oncotarget.11057

Matthieu Corvaisier, Marjolaine Bauzone, François Corfiotti, Florence Renaud, Mehdi El Amrani, Didier Monté, Stéphanie Truant, Emmanuelle Leteurtre, Pierre Formstecher, Isabelle Van Seuningen, Christian Gespach,  and Guillemette Huet
56699-56712
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Slowing down glioblastoma progression in mice by running or the anti-malarial drug dihydroartemisinin? Induction of oxidative stress in murine glioblastoma therapy

Slowing down glioblastoma progression in mice by running or the anti-malarial drug dihydroartemisinin? Induction of oxidative stress in murine glioblastoma therapy

https://doi.org/10.18632/oncotarget.10723

Dieter Lemke, Hans-Werner Pledl, Markus Zorn, Manfred Jugold, Ed Green, Jonas Blaes, Sarah Löw, Anne Hertenstein, Martina Ott, Felix Sahm, Ann-Catherine Steffen, Markus Weiler, Frank Winkler, Michael Platten, Zhen Dong,  and Wolfgang Wick
56713-56725
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Comparative proteomic profiling of refractory/relapsed multiple myeloma reveals biomarkers involved in resistance to bortezomib-based therapy

Comparative proteomic profiling of refractory/relapsed multiple myeloma reveals biomarkers involved in resistance to bortezomib-based therapy

https://doi.org/10.18632/oncotarget.11059

Dominik Dytfeld, Magdalena Luczak, Tomasz Wrobel, Lidia Usnarska-Zubkiewicz, Katarzyna Brzezniakiewicz, Krzysztof Jamroziak, Krzysztof Giannopoulos, Anna Przybylowicz-Chalecka, Blazej Ratajczak, Joanna Czerwinska-Rybak, Adam Nowicki, Monika Joks, Elzbieta Czechowska, Magdalena Zawartko, Tomasz Szczepaniak, Norbert Grzasko, Marta Morawska, Maciej Bochenek, Tadeusz Kubicki, Michalina Morawska, Katarzyna Tusznio, Andrzej Jakubowiak,  and Mieczysław Komarnicki
56726-56736
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Genetic variations in apoptosis pathway and the risk of ovarian cancer

Genetic variations in apoptosis pathway and the risk of ovarian cancer

https://doi.org/10.18632/oncotarget.10772

Hui Xie, Wade Tao, Xifeng Wu,  and Jian Gu
56737-56745
Abstract  |  PDF  |  HTML  |  Order a Reprint

Genomic complexity and dynamics of clonal evolution in childhood acute myeloid leukemia studied with whole-exome sequencing

Genomic complexity and dynamics of clonal evolution in childhood acute myeloid leukemia studied with whole-exome sequencing

https://doi.org/10.18632/oncotarget.10778

Riccardo Masetti, Ilaria Castelli, Annalisa Astolfi, Salvatore Nicola Bertuccio, Valentina Indio, Marco Togni, Tamara Belotti, Salvatore Serravalle, Giuseppe Tarantino, Marco Zecca, Martina Pigazzi, Giuseppe Basso, Andrea Pession,  and Franco Locatelli
56746-56757
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

An integrative framework to identify cell death-related microRNAs in esophageal squamous cell carcinoma

An integrative framework to identify cell death-related microRNAs in esophageal squamous cell carcinoma

https://doi.org/10.18632/oncotarget.10779

Bing-Li Wu, Dong Wang, Wen-Jing Bai, Fan Zhang, Xing Zhao, Ying Yi, Ting Zhang, Wen-Jun Shen, En-Min Li, Li-Yan Xu,  and Jian-Zhen Xu
56758-56766
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Delphinidin induces apoptosis via cleaved HDAC3-mediated p53 acetylation and oligomerization in prostate cancer cells

Delphinidin induces apoptosis via cleaved HDAC3-mediated p53 acetylation and oligomerization in prostate cancer cells

https://doi.org/10.18632/oncotarget.10790

Mi-Hyeon Jeong, Hyeonseok Ko, Hyelin Jeon, Gi-Jun Sung, Soo-Yeon Park, Woo Jin Jun, Yoo-Hyun Lee, Jeongmin Lee, Sang-wook Lee, Ho-Geun Yoon,  and Kyung-Chul Choi
56767-56780
Abstract  |  PDF  |  HTML  |  Order a Reprint

Gene expression analysis of TIL rich HPV-driven head and neck tumors reveals a distinct B-cell signature when compared to HPV independent tumors

Gene expression analysis of TIL rich HPV-driven head and neck tumors reveals a distinct B-cell signature when compared to HPV independent tumors

https://doi.org/10.18632/oncotarget.10788

Oliver Wood, Jeongmin Woo, Gregory Seumois, Natalia Savelyeva, Katy J. McCann, Divya Singh, Terry Jones, Lailah Peel, Michael S. Breen, Matthew Ward, Eva Garrido Martin, Tilman Sanchez-Elsner, Gareth Thomas, Pandurangan Vijayanand, Christopher H. Woelk, Emma King,  and Christian Ottensmeier
56781-56797
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Methylation of S100A8 is a promising diagnosis and prognostic marker in hepatocellular carcinoma

Methylation of S100A8 is a promising diagnosis and prognostic marker in hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.10792

Kun Liu, Yuening Zhang, Chengdong Zhang, Qinle Zhang, Jiatong Li, Feifan Xiao, Yingfang Li, Ruoheng Zhang, Dongwei Dou, Jiezhen Liang, Jian Qin, Zhidi Lin, Dong Zhao, Min Jiang, Zhenxin Liang, Jie Su, Vanaparthy Pranay Gupta, Min He,  and Xiaoli Yang
56798-56810
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Inhibition of Mnk enhances apoptotic activity of cytarabine in acute myeloid leukemia cells

Inhibition of Mnk enhances apoptotic activity of cytarabine in acute myeloid leukemia cells

https://doi.org/10.18632/oncotarget.10796

Peng Li, Sarah Diab, Mingfeng Yu, Julian Adams, Saiful Islam, Sunita K.C. Basnet, Hugo Albrecht, Robert Milne,  and Shudong Wang
56811-56825
Abstract  |  PDF  |  HTML  |  Order a Reprint

IGF-1R inhibition sensitizes breast cancer cells to ATM-related kinase (ATR) inhibitor and cisplatin

IGF-1R inhibition sensitizes breast cancer cells to ATM-related kinase (ATR) inhibitor and cisplatin

https://doi.org/10.18632/oncotarget.10862

Ciara H. O’Flanagan, Sandra O’Shea, Amy Lyons, Fionola M. Fogarty, Nuala McCabe, Richard D. Kennedy,  and Rosemary O’Connor
56826-56841
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Targeting XBP1-mediated β-catenin expression associated with bladder cancer with newly synthetic Oridonin analogues

Targeting XBP1-mediated β-catenin expression associated with bladder cancer with newly synthetic Oridonin analogues

https://doi.org/10.18632/oncotarget.10863

Wei Chen, Jiancheng Zhou, Kaijie Wu, Jun Huang, Ye Ding, Eun-Jin Yun, Bin Wang, Chunyong Ding, Elizabeth Hernandez, John Santoyo, Haiying Chen, Ho Lin, Arthur Sagalowsky, Dalin He, Jia Zhou,  and Jer-Tsong Hsieh
56842-56854
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Tumor exosome-mediated promotion of adhesion to mesothelial cells in gastric cancer cells

Tumor exosome-mediated promotion of adhesion to mesothelial cells in gastric cancer cells

https://doi.org/10.18632/oncotarget.10869

Tomohiro Arita, Daisuke Ichikawa, Hirotaka Konishi, Shuhei Komatsu, Atsushi Shiozaki, Shinpei Ogino, Yuji Fujita, Hidekazu Hiramoto, Junichi Hamada, Katsutoshi Shoda, Toshiyuki Kosuga, Hitoshi Fujiwara, Kazuma Okamoto,  and Eigo Otsuji
56855-56863
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Inhibition of cyclin dependent kinase 9 by dinaciclib suppresses cyclin B1 expression and tumor growth in triple negative breast cancer

Inhibition of cyclin dependent kinase 9 by dinaciclib suppresses cyclin B1 expression and tumor growth in triple negative breast cancer

https://doi.org/10.18632/oncotarget.10870

Sandeep Rajput, Nimmish Khera, Zhanfang Guo, Jeremy Hoog, Shunqiang Li,  and Cynthia X. Ma
56864-56875
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Fulvestrant inhibits growth of triple negative breast cancer and synergizes with tamoxifen in ERα positive breast cancer by up-regulation of ERβ

Fulvestrant inhibits growth of triple negative breast cancer and synergizes with tamoxifen in ERα positive breast cancer by up-regulation of ERβ

https://doi.org/10.18632/oncotarget.10871

Ameet K. Mishra, Annelie Abrahamsson,  and Charlotta Dabrosin
56876-56888
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Caveolin-1 promotes Ewing sarcoma metastasis regulating MMP-9 expression through MAPK/ERK pathway

Caveolin-1 promotes Ewing sarcoma metastasis regulating MMP-9 expression through MAPK/ERK pathway

https://doi.org/10.18632/oncotarget.10872

Laura Lagares-Tena, Silvia García-Monclús, Roser López-Alemany, Olga Almacellas-Rabaiget, Juan Huertas-Martínez, Miguel Sáinz-Jaspeado, Silvia Mateo-Lozano, Carlos Rodríguez-Galindo, Santiago Rello-Varona, David Herrero-Martín,  and Oscar M. Tirado
56889-56903
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A three-dimensional collagen scaffold cell culture system for screening anti-glioma therapeutics

A three-dimensional collagen scaffold cell culture system for screening anti-glioma therapeutics

https://doi.org/10.18632/oncotarget.10885

Donglai Lv, Shi-cang Yu, Yi-fang Ping, Haibo Wu, Xilong Zhao, Huarong Zhang, Youhong Cui, Bing Chen, Xia Zhang, Jianwu Dai, Xiu-wu Bian,  and Xiao-hong Yao
56904-56914
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Association between dietary nitrate and nitrite intake and site-specific cancer risk: evidence from observational studies

Association between dietary nitrate and nitrite intake and site-specific cancer risk: evidence from observational studies

https://doi.org/10.18632/oncotarget.10917

Li Xie, Miao Mo, Hui-Xun Jia, Fei Liang, Jing Yuan,  and Ji Zhu
56915-56932
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Loss of ARID1A expression leads to sensitivity to ROS-inducing agent elesclomol in gynecologic cancer cells

Loss of ARID1A expression leads to sensitivity to ROS-inducing agent elesclomol in gynecologic cancer cells

https://doi.org/10.18632/oncotarget.10921

Suet-Yan Kwan, Xuanjin Cheng, Yvonne T.M. Tsang, Jong-Sun Choi, Suet-Ying Kwan, Daisy I. Izaguirre, Hoi-Shan Kwan, David M. Gershenson,  and Kwong-Kwok Wong
56933-56943
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

IGF-II induced by hepatitis B virus X protein regulates EMT via SUMO mediated loss of E-cadherin in mice

IGF-II induced by hepatitis B virus X protein regulates EMT via SUMO mediated loss of E-cadherin in mice

https://doi.org/10.18632/oncotarget.10922

Hye-Lin Ha, Taeho Kwon, In Seon Bak, Raymond L. Erikson, Bo Yeon Kim,  and Dae-Yeul Yu
56944-56957
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A role for activated Cdc42 in glioblastoma multiforme invasion

A role for activated Cdc42 in glioblastoma multiforme invasion

https://doi.org/10.18632/oncotarget.10925

Hidehiro Okura, Brian J. Golbourn, Uswa Shahzad, Sameer Agnihotri, Nesrin Sabha, Jonathan R. Krieger, Carlyn A. Figueiredo, Alan Chalil, Natalie Landon-Brace, Alexandra Riemenschneider, Hajime Arai, Christian A. Smith, Songli Xu, Stefan Kaluz, Adam I. Marcus, Erwin G. Van Meir,  and James T. Rutka
56958-56975
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Telomere status in chronic lymphocytic leukemia with TP53 disruption

Telomere status in chronic lymphocytic leukemia with TP53 disruption

https://doi.org/10.18632/oncotarget.10927

Romain Guièze, Mélanie Pages, Lauren Véronèse, Patricia Combes, Richard Lemal, Mathilde Gay-bellile, Martine Chauvet, Fabrice Kwiatkowski, Bruno Pereira, Philippe Vago, Jacques-Olivier Bay, Olivier Tournilhac,  and Andreï Tchirkov
56976-56985
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Functional intratumoral lymphatics in patient-derived xenograft models of squamous cell carcinoma of the uterine cervix: implications for lymph node metastasis

Functional intratumoral lymphatics in patient-derived xenograft models of squamous cell carcinoma of the uterine cervix: implications for lymph node metastasis

https://doi.org/10.18632/oncotarget.10931

Einar K. Rofstad, Ruixia Huang, Kanthi Galappathi, Lise Mari K. Andersen, Catherine S. Wegner, Anette Hauge, Jon-Vidar Gaustad,  and Trude G. Simonsen
56986-56997
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A retrospective analysis in patients with EGFR-mutant lung adenocarcinoma: is EGFR mutation associated with a higher incidence of brain metastasis?

A retrospective analysis in patients with EGFR-mutant lung adenocarcinoma: is EGFR mutation associated with a higher incidence of brain metastasis?

https://doi.org/10.18632/oncotarget.10933

Guang Han, Jianping Bi, Wenyong Tan, Xueyan Wei, Xiaohong Wang, Xiaofang Ying, Xiaofang Guo, Xiaoyi Zhou, Desheng Hu,  and Weining Zhen
56998-57010
Abstract  |  PDF  |  HTML  |  Order a Reprint

Functional single nucleotide polymorphisms within the cyclin-dependent kinase inhibitor 2A/2B region affect pancreatic cancer risk

Functional single nucleotide polymorphisms within the cyclin-dependent kinase inhibitor 2A/2B region affect pancreatic cancer risk

https://doi.org/10.18632/oncotarget.10935

Daniele Campa, Manuela Pastore, Manuel Gentiluomo, Renata Talar-Wojnarowska, Juozas Kupcinskas, Ewa Malecka-Panas, John P. Neoptolemos, Willem Niesen, Pavel Vodicka, Gianfranco Delle Fave, H. Bas Bueno-de-Mesquita, Maria Gazouli, Paola Pacetti, Milena Di Leo, Hidemi Ito, Harald Klüter, Pavel Soucek, Vincenzo Corbo, Kenji Yamao, Satoyo Hosono, Rudolf Kaaks, Yogesh Vashist, Domenica Gioffreda, Oliver Strobel, Yasuhiro Shimizu, Frederike Dijk, Angelo Andriulli, Audrius Ivanauskas, Peter Bugert, Francesca Tavano, Ludmila Vodickova, Carlo Federico Zambon, Martin Lovecek, Stefano Landi, Timothy J. Key, Ugo Boggi, Raffaele Pezzilli, Krzysztof Jamroziak, Beatrice Mohelnikova-Duchonova, Andrea Mambrini, Franco Bambi, Olivier Busch, Valerio Pazienza, Roberto Valente, George E. Theodoropoulos, Thilo Hackert, Gabriele Capurso, Giulia Martina Cavestro, Claudio Pasquali, Daniela Basso, Cosimo Sperti, Keitaro Matsuo, Markus Büchler, Kay-Tee Khaw, Jakob Izbicki, Eithne Costello, Verena Katzke, Christoph Michalski, Anna Stepien, Cosmeri Rizzato,  and Federico Canzian
57011-57020
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Targeted deep sequencing improves outcome stratification in chronic myelomonocytic leukemia with low risk cytogenetic features

Targeted deep sequencing improves outcome stratification in chronic myelomonocytic leukemia with low risk cytogenetic features

https://doi.org/10.18632/oncotarget.10937

Laura Palomo, Olga Garcia, Montse Arnan, Blanca Xicoy, Francisco Fuster, Marta Cabezón, Rosa Coll, Vera Ademà, Javier Grau, Maria-José Jiménez, Helena Pomares, Sílvia Marcé, Mar Mallo, Fuensanta Millá, Esther Alonso, Anna Sureda, David Gallardo, Evarist Feliu, Josep-Maria Ribera, Francesc Solé,  and Lurdes Zamora
57021-57035
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Coexistence of JAK2 and CALR mutations and their clinical implications in patients with essential thrombocythemia

Coexistence of JAK2 and CALR mutations and their clinical implications in patients with essential thrombocythemia

https://doi.org/10.18632/oncotarget.10958

Min-Gu Kang, Hyun-Woo Choi, Jun Hyung Lee, Yong Jun Choi, Hyun-Jung Choi, Jong-Hee Shin, Soon-Pal Suh, Michael Szardenings, Hye-Ran Kim,  and Myung-Geun Shin
57036-57049
Abstract  |  PDF  |  HTML  |  Order a Reprint

HPV16 E6-E7 induces cancer stem-like cells phenotypes in esophageal squamous cell carcinoma through the activation of PI3K/Akt signaling pathway in vitro and in vivo

HPV16 E6-E7 induces cancer stem-like cells phenotypes in esophageal squamous cell carcinoma through the activation of PI3K/Akt signaling pathway in vitro and in vivo

https://doi.org/10.18632/oncotarget.10959

Ruxing Xi, Shupei Pan, Xin Chen, Beina Hui, Li Zhang, Shenbo Fu, Xiaolong Li, Xuanwei Zhang, Tuotuo Gong, Jia Guo, Xiaozhi Zhang,  and Shaomin Che
57050-57065
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Twist1-induced epithelial-mesenchymal transition according to microsatellite instability status in colon cancer cells

Twist1-induced epithelial-mesenchymal transition according to microsatellite instability status in colon cancer cells

https://doi.org/10.18632/oncotarget.10974

Bo Young Oh, So-Young Kim, Yeo Song Lee, Hye Kyung Hong, Tae Won Kim, Seok Hyung Kim, Woo Yong Lee,  and Yong Beom Cho
57066-57076
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Differential expression of cyclooxygenase-2 in metastatic melanoma affects progression free survival

Differential expression of cyclooxygenase-2 in metastatic melanoma affects progression free survival

https://doi.org/10.18632/oncotarget.10976

Elisabetta Panza, Paola De Cicco, Giuseppe Ercolano, Chiara Armogida, Giosuè Scognamiglio, Anna Maria Anniciello, Gerardo Botti, Giuseppe Cirino,  and Angela Ianaro
57077-57085
Abstract  |  PDF  |  HTML  |  Order a Reprint

Expression of the p66Shc protein adaptor is regulated by the activator of transcription STAT4 in normal and chronic lymphocytic leukemia B cells

Expression of the p66Shc protein adaptor is regulated by the activator of transcription STAT4 in normal and chronic lymphocytic leukemia B cells

https://doi.org/10.18632/oncotarget.10977

Francesca Cattaneo, Laura Patrussi, Nagaja Capitani, Federica Frezzato, Mario Milco D’Elios, Livio Trentin, Gianpietro Semenzato,  and Cosima T. Baldari
57086-57098
Abstract  |  PDF  |  HTML  |  Order a Reprint

MiRNA-22 inhibits oncogene galectin-1 in hepatocellular carcinoma

MiRNA-22 inhibits oncogene galectin-1 in hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.10981

Yu You, Jia-Xin Tan, Hai-Su Dai, Hao-Wei Chen, Xue-Jun Xu, Ai-Gang Yang, Yu-Jun Zhang, Lian-Hua Bai,  and Ping Bie
57099-57116
Abstract  |  PDF  |  HTML  |  Order a Reprint

Ablation of human telomerase reverse transcriptase (hTERT) induces cellular senescence in gastric cancer through a galectin-3 dependent mechanism

Ablation of human telomerase reverse transcriptase (hTERT) induces cellular senescence in gastric cancer through a galectin-3 dependent mechanism

https://doi.org/10.18632/oncotarget.10986

Sun-Hyuk La, Seok-Jun Kim, Hyeok-Gu Kang, Han-Woong Lee,  and Kyung-Hee Chun
57117-57130
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GSK3β inactivation promotes the oncogenic functions of EZH2 and enhances methylation of H3K27 in human breast cancers

GSK3β inactivation promotes the oncogenic functions of EZH2 and enhances methylation of H3K27 in human breast cancers

https://doi.org/10.18632/oncotarget.11008

How-Wen Ko, Heng-Huan Lee, Longfei Huo, Weiya Xia, Cheng-Chieh Yang, Jennifer L. Hsu, Long-Yuan Li, Chien-Chen Lai, Li-Chuan Chan, Chien-Chia Cheng, Adam M. Labaff, Hsin-Wei Liao, Seung-Oe Lim, Chia-Wei Li, Yongkun Wei, Lei Nie, Hirohito Yamaguchi,  and Mien-Chie Hung
57131-57144
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Analysis of the chemotherapeutic effects of a propadiene compound on malignant ovarian cancer cells

Analysis of the chemotherapeutic effects of a propadiene compound on malignant ovarian cancer cells

https://doi.org/10.18632/oncotarget.11012

Shuqing Li, Lina Yang, Jingshu Wang, Fan Liang, Bin Chang, Huafen Gu, Honglin Wang, Gong Yang,  and Yaping Chen
57145-57159
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DR5 mAb-conjugated, DTIC-loaded immuno-nanoparticles effectively and specifically kill malignant melanoma cells in vivo

DR5 mAb-conjugated, DTIC-loaded immuno-nanoparticles effectively and specifically kill malignant melanoma cells in vivo

https://doi.org/10.18632/oncotarget.11014

Baoyue Ding, Wei Zhang, Xin Wu, Jeffrey Wang, Chen Xie, Xuan Huang, Shuyu Zhan, Yongxia Zheng, Yueyan Huang, Ningyin Xu, Xueying Ding,  and Shen Gao
57160-57170
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Combinatorial therapeutic targeting of BMP2 and MEK-ERK pathways in NF1-associated malignant peripheral nerve sheath tumors

Combinatorial therapeutic targeting of BMP2 and MEK-ERK pathways in NF1-associated malignant peripheral nerve sheath tumors

https://doi.org/10.18632/oncotarget.11036

Sidra Ahsan, Yubin Ge,  and Michael A. Tainsky
57171-57185
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O-GlcNAcylation of ATG4B positively regulates autophagy by increasing its hydroxylase activity

O-GlcNAcylation of ATG4B positively regulates autophagy by increasing its hydroxylase activity

https://doi.org/10.18632/oncotarget.11083

Yoon Kyung Jo, Na Yeon Park, So Jung Park, Byung-Gyu Kim, Ji Hyun Shin, Doo Sin Jo, Dong-Jun Bae, Young-Ah Suh, Jeong Ho Chang, Eun Kyung Lee, Sang-Yeob Kim, Jin Cheon Kim,  and Dong-Hyung Cho
57186-57196
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The VEGF rise in blood of bevacizumab patients is not based on tumor escape but a host-blockade of VEGF clearance

The VEGF rise in blood of bevacizumab patients is not based on tumor escape but a host-blockade of VEGF clearance

https://doi.org/10.18632/oncotarget.11084

Lejla Alidzanovic, Patrick Starlinger, Dominic Schauer, Thomas Maier, Alexandra Feldman, Elisabeth Buchberger, Judith Stift, Ulrike Koeck, Lorand Pop, Birgit Gruenberger, Thomas Gruenberger,  and Christine Brostjan
57197-57212
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Celecoxib and sulindac inhibit TGF-β1-induced epithelial-mesenchymal transition and suppress lung cancer migration and invasion via downregulation of sirtuin 1

Celecoxib and sulindac inhibit TGF-β1-induced epithelial-mesenchymal transition and suppress lung cancer migration and invasion via downregulation of sirtuin 1

https://doi.org/10.18632/oncotarget.11127

Byong-Ki Cha, Young-Suk Kim, Ki-Eun Hwang, Kyung-Hwa Cho, Seon-Hee Oh, Byoung-Ryun Kim, Hong-Young Jun, Kwon-Ha Yoon, Eun-Taik Jeong,  and Hak-Ryul Kim
57213-57227
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The gain and loss of long noncoding RNA associated-competing endogenous RNAs in prostate cancer

The gain and loss of long noncoding RNA associated-competing endogenous RNAs in prostate cancer

https://doi.org/10.18632/oncotarget.11128

Dianming Liu, Xuexin Yu, Shuyuan Wang, Enyu Dai, Leiming Jiang, Jing Wang, Qian Yang, Feng Yang, Shunheng Zhou,  and Wei Jiang
57228-57238
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Integrative analysis of miRNA and gene expression reveals regulatory networks in tamoxifen-resistant breast cancer

Integrative analysis of miRNA and gene expression reveals regulatory networks in tamoxifen-resistant breast cancer

https://doi.org/10.18632/oncotarget.11136

Tejal Joshi, Daniel Elias, Jan Stenvang, Carla L. Alves, Fei Teng, Maria B. Lyng, Anne E. Lykkesfeldt, Nils Brünner, Jun Wang, Ramneek Gupta, Christopher T. Workman,  and Henrik J. Ditzel
57239-57253
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miR-31 targets ARID1A and enhances the oncogenicity and stemness of head and neck squamous cell carcinoma

miR-31 targets ARID1A and enhances the oncogenicity and stemness of head and neck squamous cell carcinoma

https://doi.org/10.18632/oncotarget.11138

Wen-Cheng Lu, Chung-Ji Liu, Hsi-Feng Tu, Yu-Tung Chung, Cheng-Chieh Yang, Shou-Yen Kao, Kuo-Wei Chang,  and Shu-Chun Lin
57254-57267
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Clinical Research Papers

Intravascular emboli is an independent risk factor for the prognosis of stage III colorectal cancer patients after radical surgery

Intravascular emboli is an independent risk factor for the prognosis of stage III colorectal cancer patients after radical surgery

https://doi.org/10.18632/oncotarget.11266

Qian Pei, Hong Zhu, Fengbo Tan, Nanhui Yu, Zhongyi Zhou, Yuan Zhou, Xiangping Song, Yuqiang Li, Yiming Tao, Sai Zhang, Liling Li, Qingling Li,  and Haiping Pei
57268-57276
Abstract  |  PDF  |  HTML  |  Order a Reprint

Optical imaging of gastric cancer with near-infrared heptamethine carbocyanine fluorescence dyes

Optical imaging of gastric cancer with near-infrared heptamethine carbocyanine fluorescence dyes

https://doi.org/10.18632/oncotarget.10031

Ningning Zhao, Caiqin Zhang, Yong Zhao, Bing Bai, Jiaze An, Hai Zhang, Jason Boyang Wu,  and Changhong Shi
57277-57289
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Predictive value of chemotherapy-related high-density lipoprotein cholesterol (HDL) elevation in patients with colorectal cancer receiving adjuvant chemotherapy: an exploratory analysis of 851 cases

Predictive value of chemotherapy-related high-density lipoprotein cholesterol (HDL) elevation in patients with colorectal cancer receiving adjuvant chemotherapy: an exploratory analysis of 851 cases

https://doi.org/10.18632/oncotarget.10145

Yun Wang, Zhi-qiang Wang, Feng-hua Wang, Xue-fen Lei, Shu-mei Yan, De-shen Wang, Fei Zhang, Rui-hua Xu, Ling-yun Wang,  and Yu-hong Li
57290-57300
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Fulvestrant 500 mg vs 250 mg in postmenopausal women with estrogen receptor-positive advanced breast cancer: a randomized, double-blind registrational trial in China

Fulvestrant 500 mg vs 250 mg in postmenopausal women with estrogen receptor-positive advanced breast cancer: a randomized, double-blind registrational trial in China

https://doi.org/10.18632/oncotarget.10254

Qingyuan Zhang, Zhimin Shao, Kunwei Shen, Li Li, Jifeng Feng, Zhongsheng Tong, Kangsheng Gu, Xiaojia Wang, Binghe Xu, Guofang Sun, Huifang Chen, Yuri Rukazenkov,  and Zefei Jiang
57301-57309
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A phase II study of concurrent chemoradiotherapy and erlotinib for inoperable esophageal squamous cell carcinoma

A phase II study of concurrent chemoradiotherapy and erlotinib for inoperable esophageal squamous cell carcinoma

https://doi.org/10.18632/oncotarget.9809

Chuanhua Zhao, Li Lin, Jianzhi Liu, Rongrui Liu, Yuling Chen, Feijiao Ge, Ru Jia, Yang Jin, Yan Wang,  and Jianming Xu
57310-57316
Abstract  |  PDF  |  HTML  |  Order a Reprint

Preoperative chemoradiotherapy creates an opportunity to perform sphincter preserving resection for low-lying locally advanced rectal cancer based on an oncologic outcome study

Preoperative chemoradiotherapy creates an opportunity to perform sphincter preserving resection for low-lying locally advanced rectal cancer based on an oncologic outcome study

https://doi.org/10.18632/oncotarget.10303

Jun-Zhong Lin, Jian-Hong Peng, Aiham Qdaisat, Zhen-Hai Lu, Xiao-Jun Wu, Gong Chen, Pei-Rong Ding, Li-Ren Li, Yuan-Hong Gao, Zhi-Fan Zeng, De-Sen Wan,  and Zhi-Zhong Pan
57317-57326
Abstract  |  PDF  |  HTML  |  Order a Reprint

Reviews

Epimutational profile of hematologic malignancies as attractive target for new epigenetic therapies

Epimutational profile of hematologic malignancies as attractive target for new epigenetic therapies

https://doi.org/10.18632/oncotarget.10033

Elisabetta Fratta, Barbara Montico, Aurora Rizzo, Francesca Colizzi, Luca Sigalotti,  and Riccardo Dolcetti
57327-57350
Abstract  |  PDF  |  HTML  |  Order a Reprint

uPA/uPAR and SERPINE1 in head and neck cancer: role in tumor resistance, metastasis, prognosis and therapy

uPA/uPAR and SERPINE1 in head and neck cancer: role in tumor resistance, metastasis, prognosis and therapy

https://doi.org/10.18632/oncotarget.10344

Miguel Angel Pavón, Irene Arroyo-Solera, Maria Virtudes Céspedes, Isolda Casanova, Xavier León,  and Ramón Mangues
57351-57366
Abstract  |  PDF  |  HTML  |  Order a Reprint

Local hyperthermia in head and neck cancer: mechanism, application and advance

Local hyperthermia in head and neck cancer: mechanism, application and advance

https://doi.org/10.18632/oncotarget.10350

Shiyu Gao, Min Zheng, Xiaohua Ren, Yaling Tang,  and Xinhua Liang
57367-57378
Abstract  |  PDF  |  HTML  |  Order a Reprint

LncRNAs in pancreatic cancer

LncRNAs in pancreatic cancer

https://doi.org/10.18632/oncotarget.10545

Xiaoyi Huang, Xiaosong Zhi, Yisha Gao, Na Ta, Hui Jiang,  and Jianming Zheng
57379-57390
Abstract  |  PDF  |  HTML  |  Order a Reprint

Necroptosis in tumorigenesis, activation of anti-tumor immunity, and cancer therapy

Necroptosis in tumorigenesis, activation of anti-tumor immunity, and cancer therapy

https://doi.org/10.18632/oncotarget.10548

Mao-Bin Meng, Huan-Huan Wang, Yao-Li Cui, Zhi-Qiang Wu, Yang-Yang Shi, Nicholas G. Zaorsky, Lei Deng, Zhi-Yong Yuan, You Lu,  and Ping Wang
57391-57413
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

NETs: organ-related epigenetic derangements and potential clinical applications

NETs: organ-related epigenetic derangements and potential clinical applications

https://doi.org/10.18632/oncotarget.10598

Mauro Cives, Valeria Simone, Francesca Maria Rizzo,  and Franco Silvestris
57414-57429
Abstract  |  PDF  |  HTML  |  Order a Reprint

Progress and perspective of TBX6 gene in congenital vertebral malformations

Progress and perspective of TBX6 gene in congenital vertebral malformations

https://doi.org/10.18632/oncotarget.10619

Weisheng Chen, Jiaqi Liu, Dongtang Yuan, Yuzhi Zuo, Zhenlei Liu, Sen Liu, Qiankun Zhu, Guixing Qiu, Shishu Huang, Philip F. Giampietro, Feng Zhang, Nan Wu,  and Zhihong Wu
57430-57441
Abstract  |  PDF  |  HTML  |  Order a Reprint

Potential role of the N-MYC downstream-regulated gene family in reprogramming cancer metabolism under hypoxia

Potential role of the N-MYC downstream-regulated gene family in reprogramming cancer metabolism under hypoxia

https://doi.org/10.18632/oncotarget.10684

Ga Young Lee, Yang-Sook Chun, Hyun-Woo Shin,  and Jong-Wan Park
57442-57451
Abstract  |  PDF  |  HTML  |  Order a Reprint

Epigenetics in myeloid derived suppressor cells: a sheathed sword towards cancer

Epigenetics in myeloid derived suppressor cells: a sheathed sword towards cancer

https://doi.org/10.18632/oncotarget.10767

Chao Zhang, Shuo Wang, Yufeng Liu,  and Cheng Yang
57452-57463
Abstract  |  PDF  |  HTML  |  Order a Reprint

Genetic polymorphisms of mTOR and cancer risk: a systematic review and updated meta-analysis

Genetic polymorphisms of mTOR and cancer risk: a systematic review and updated meta-analysis

https://doi.org/10.18632/oncotarget.10805

Jin Zining, Xu Lu, He Caiyun,  and Yuan Yuan
57464-57480
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint


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