Oncotarget

Vol 7, No 34

August 23, 2016

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About The Cover

CNS germinomas are characterized by global demethylation, chromosomal instability and mutational activation of the Kit-, Ras/Raf/Erk- and Akt-pathways. See Schulte et al.

 

Table of Contents

Editorial

Targeting MITF in the tolerance-phase

Targeting MITF in the tolerance-phase

https://doi.org/10.18632/oncotarget.9423

Imanol Arozarena, Michael P. Smith,  and Claudia Wellbrock
54094-54095
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Research Perspectives

Metformin and cancer: Quo vadis et cui bono?

Metformin and cancer: Quo vadis et cui bono?

https://doi.org/10.18632/oncotarget.10262

Javier A. Menendez, Begoña Martin-Castillo,  and Jorge Joven
54096-54101
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Priority Research Papers

Novel function of MDA-9/Syntenin (SDCBP) as a regulator of survival and stemness in glioma stem cells

Novel function of MDA-9/Syntenin (SDCBP) as a regulator of survival and stemness in glioma stem cells

https://doi.org/10.18632/oncotarget.10851

Sarmistha Talukdar, Swadesh K. Das, Anjan K. Pradhan, Luni Emdad, Xue-Ning Shen, Jolene J. Windle, Devanand Sarkar,  and Paul B. Fisher
54102-54119
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Effective combination therapies in preclinical endocrine resistant breast cancer models harboring ER mutations

Effective combination therapies in preclinical endocrine resistant breast cancer models harboring ER mutations

https://doi.org/10.18632/oncotarget.10852

Brendon Ladd, Anne Marie Mazzola, Teeru Bihani, Zhongwu Lai, James Bradford, Michael Collins, Evan Barry, Anne U. Goeppert, Hazel M. Weir, Kelly Hearne, Jonathan G. Renshaw, Morvarid Mohseni, Elaine Hurt, Sanjoo Jalla, Haifeng Bao, Robert Hollingsworth, Corinne Reimer, Michael Zinda, Stephen Fawell,  and Celina M. D’Cruz
54120-54136
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

EGFR-targeted therapy results in dramatic early lung tumor regression accompanied by imaging response and immune infiltration in EGFR mutant transgenic mouse models

EGFR-targeted therapy results in dramatic early lung tumor regression accompanied by imaging response and immune infiltration in EGFR mutant transgenic mouse models

https://doi.org/10.18632/oncotarget.11021

Abhilash Venugopalan, Min-Jung Lee, Gang Niu, José Medina-Echeverz, Yusuke Tomita, Martin J. Lizak, Constance M. Cultraro, Robert Mark Simpson, Xiaoyuan Chen, Jane B. Trepel,  and Udayan Guha
54137-54156
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ΔNp63 drives metastasis in breast cancer cells via PI3K/CD44v6 axis

ΔNp63 drives metastasis in breast cancer cells via PI3K/CD44v6 axis

https://doi.org/10.18632/oncotarget.11022

Simone Di Franco, Alice Turdo, Antonina Benfante, Maria L. Colorito, Miriam Gaggianesi, Tiziana Apuzzo, Raju Kandimalla, Aurora Chinnici, Daniela Barcaroli, Laura Rosa Mangiapane, Giuseppe Pistone, Salvatore Vieni, Eliana Gulotta, Francesco Dieli, Jan Paul Medema, Giorgio Stassi, Vincenzo De Laurenzi,  and Matilde Todaro
54157-54173
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Upregulation of long noncoding RNA MIAT in aggressive form of chronic lymphocytic leukemias

Upregulation of long noncoding RNA MIAT in aggressive form of chronic lymphocytic leukemias

https://doi.org/10.18632/oncotarget.11099

Arash Sattari, Hasan Siddiqui, Farzaneh Moshiri, Apollinaire Ngankeu, Tatsuya Nakamura, Thomas J. Kipps,  and Carlo M. Croce
54174-54182
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Research Papers: Gerotarget (Focus on Aging)

Royal jelly promotes DAF-16-mediated proteostasis to tolerate β-amyloid toxicity in C. elegans model of Alzheimer’s disease

Royal jelly promotes DAF-16-mediated proteostasis to tolerate β-amyloid toxicity in C. elegans model of Alzheimer’s disease

https://doi.org/10.18632/oncotarget.10857

Xiaoxia Wang, Min Cao,  and Yuqing Dong
54183-54193
Abstract  |  PDF  |  HTML  |  Order a Reprint

Age is associated with time in therapeutic range for warfarin therapy in patients with atrial fibrillation

Age is associated with time in therapeutic range for warfarin therapy in patients with atrial fibrillation

https://doi.org/10.18632/oncotarget.10944

Leiliane Rodrigues Marcatto, Luciana Sacilotto, Francisco Carlos da Costa Darrieux, Denise Tessariol Hachul, Maurício Ibrahim Scanavacca, Jose Eduardo Krieger, Alexandre Costa Pereira,  and Paulo Caleb Junior Lima Santos
54194-54199
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Dose-dependent genotype effects of BDNF Val66Met polymorphism on default mode network in early stage Alzheimer’s disease

Dose-dependent genotype effects of BDNF Val66Met polymorphism on default mode network in early stage Alzheimer’s disease

https://doi.org/10.18632/oncotarget.11027

Pin-Hsuan Lin, Shih-Jen Tsai, Chi-Wei Huang, Liu Mu-En, Shih-Wei Hsu, Chen-Chang Lee, Nai-Ching Chen, Ya-Ting Chang, Min-Yu Lan,  and Chiung-Chih Chang
54200-54214
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Increased Rab35 expression is a potential biomarker and implicated in the pathogenesis of Parkinson’s disease

Increased Rab35 expression is a potential biomarker and implicated in the pathogenesis of Parkinson’s disease

https://doi.org/10.18632/oncotarget.11090

Ching-Chi Chiu, Tu-Hsueh Yeh, Szu-Chia Lai, Yi-Hsin Weng, Yin-Cheng Huang, Yi-Chuan Cheng, Rou-Shayn Chen, Ying-Zu Huang, June Hung, Chiung-Chu Chen, Wey-Yil Lin, Hsiu-Chen Chang, Yu-Jie Chen, Chao-Lang Chen, Hsin-Yi Chen, Yan-Wei Lin, Yah-Huei Wu-Chou, Hung-Li Wang,  and Chin-Song Lu
54215-54227
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Research Papers: Pathology

FOXC2 disease-mutations identified in lymphedema-distichiasis patients cause both loss and gain of protein function

FOXC2 disease-mutations identified in lymphedema-distichiasis patients cause both loss and gain of protein function

https://doi.org/10.18632/oncotarget.9797

Daniela Tavian, Sara Missaglia, Paolo E. Maltese, Sandro Michelini, Alessandro Fiorentino, Maurizio Ricci, Roberta Serrani, Michael A. Walter,  and Matteo Bertelli
54228-54239
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Interferon gamma peptidomimetic targeted to interstitial myofibroblasts attenuates renal fibrosis after unilateral ureteral obstruction in mice

Interferon gamma peptidomimetic targeted to interstitial myofibroblasts attenuates renal fibrosis after unilateral ureteral obstruction in mice

https://doi.org/10.18632/oncotarget.11095

Fariba Poosti, Ruchi Bansal, Saleh Yazdani, Jai Prakash, Leonie Beljaars, Jacob van den Born, Martin H. de Borst, Harry van Goor, Jan-Luuk Hillebrands,  and Klaas Poelstra
54240-54252
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Tumor specific mutations in TERT promoter and CTNNB1 gene in hepatitis B and hepatitis C related hepatocellular carcinoma

Tumor specific mutations in TERT promoter and CTNNB1 gene in hepatitis B and hepatitis C related hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.9801

Francesca Pezzuto, Francesco Izzo, Luigi Buonaguro, Clorinda Annunziata, Fabiana Tatangelo, Gerardo Botti, Franco M. Buonaguro,  and Maria Lina Tornesello
54253-54262
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Inhibition of heat shock protein 90 improves pulmonary arteriole remodeling in pulmonary arterial hypertension

Inhibition of heat shock protein 90 improves pulmonary arteriole remodeling in pulmonary arterial hypertension

https://doi.org/10.18632/oncotarget.10855

Guo-Kun Wang, Song-Hua Li, Zhi-Min Zhao, Su-Xuan Liu, Guan-Xin Zhang, Fan Yang, Yang Wang, Feng Wu, Xian-Xian Zhao,  and Zhi-Yun Xu
54263-54273
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Cardiac fibrosis in mouse expressing DsRed tetramers involves chronic autophagy and proteasome degradation insufficiency

Cardiac fibrosis in mouse expressing DsRed tetramers involves chronic autophagy and proteasome degradation insufficiency

https://doi.org/10.18632/oncotarget.11026

Tsung-Hsien Chen, Mei-Ru Chen, Tzu-Yin Chen, Tzu-Chin Wu, Shan-Wen Liu, Ching-Han Hsu, Gan-Guang Liou, Yu-Ying Kao, Guo-Chung Dong, Pao-Hsien Chu, Jiunn-Wang Liao,  and Kurt Ming-Chao Lin
54274-54289
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

NLRP3 inflammasome activation is involved in Ang II-induced kidney damage via mitochondrial dysfunction

NLRP3 inflammasome activation is involved in Ang II-induced kidney damage via mitochondrial dysfunction

https://doi.org/10.18632/oncotarget.11091

Yi Wen, Yiran Liu, Taotao Tang, Linli Lv, Hong Liu, Kunling Ma,  and Bicheng Liu
54290-54302
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Binge ethanol exposure causes endoplasmic reticulum stress, oxidative stress and tissue injury in the pancreas

Binge ethanol exposure causes endoplasmic reticulum stress, oxidative stress and tissue injury in the pancreas

https://doi.org/10.18632/oncotarget.11103

Zhenhua Ren, Xin Wang, Mei Xu, Fanmuyi Yang, Jacqueline A. Frank, Zun-ji Ke,  and Jia Luo
54303-54316
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Prolyl hydroxylase 2 (PHD2) inhibition protects human renal epithelial cells and mice kidney from hypoxia injury

Prolyl hydroxylase 2 (PHD2) inhibition protects human renal epithelial cells and mice kidney from hypoxia injury

https://doi.org/10.18632/oncotarget.11104

Yi Fang, Hui Zhang, Yihong Zhong,  and Xiaoqiang Ding
54317-54328
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Towards a multi protein and mRNA expression of biological predictive and distinguish model for post stroke depression

Towards a multi protein and mRNA expression of biological predictive and distinguish model for post stroke depression

https://doi.org/10.18632/oncotarget.11105

Yingying Yue, Haitang Jiang, Rui Liu, Yingying Yin, Yuqun Zhang, Jinfeng Liang, Shenghua Li, Jun Wang, Jianxin Lu, Deqin Geng, Aiqin Wu,  and Yonggui Yuan
54329-54338
Abstract  |  PDF  |  HTML  |  Order a Reprint

Research Papers: Immunology

Inherent low Erk and p38 activity reduce Fas Ligand expression and degranulation in T helper 17 cells leading to activation induced cell death resistance

Inherent low Erk and p38 activity reduce Fas Ligand expression and degranulation in T helper 17 cells leading to activation induced cell death resistance

https://doi.org/10.18632/oncotarget.10913

Doureradjou Peroumal, Thiruvaimozhi Abimannan, Ravichandra Tagirasa, Jyothi Ranjan Parida, Santosh Kumar Singh, Prasantha Padhan,  and Satish Devadas
54339-54359
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Combination of specific allergen and probiotics induces specific regulatory B cells and enhances specific immunotherapy effect on allergic rhinitis

Combination of specific allergen and probiotics induces specific regulatory B cells and enhances specific immunotherapy effect on allergic rhinitis

https://doi.org/10.18632/oncotarget.10946

Ling-Zhi Xu, Li-Tao Yang, Shu-Qi Qiu, Gui Yang, Xiang-Qian Luo, Bei-Ping Miao, Xiao-Rui Geng, Zhi-Qiang Liu, Jun Liu, Zhong Wen, Shuai Wang, Huan-Ping Zhang, Jing Li, Zhi-Gang Liu, Hua-Bin Li,  and Ping-Chang Yang
54360-54369
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

ADAR1 is vital for B cell lineage development in the mouse bone marrow

ADAR1 is vital for B cell lineage development in the mouse bone marrow

https://doi.org/10.18632/oncotarget.11029

Victoria Marcu-Malina, Sanja Goldberg, Einav Vax, Ninette Amariglio, Itamar Goldstein,  and Gideon Rechavi
54370-54379
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Systematic identification of immunodominant CD4+ T cell responses to HpaA in Helicobacter pylori infected individuals

Systematic identification of immunodominant CD4+ T cell responses to HpaA in Helicobacter pylori infected individuals

https://doi.org/10.18632/oncotarget.11092

Jian Hu, Li Chen, Wuchen Yang, Bin Li, Heqiang Sun, Shanshan Wei, Yafei He, Zhuo Zhao, Shiming Yang, Quanming Zou, Weisan Chen, Hong Guo,  and Chao Wu
54380-54391
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Myeloid cell expressed proprotein convertase FURIN attenuates inflammation

Myeloid cell expressed proprotein convertase FURIN attenuates inflammation

https://doi.org/10.18632/oncotarget.11106

Zuzet Martinez Cordova, Anna Grönholm, Ville Kytölä, Valentina Taverniti, Sanna Hämäläinen, Saara Aittomäki, Wilhelmiina Niininen, Ilkka Junttila, Antti Ylipää, Matti Nykter,  and Marko Pesu
54392-54404
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Research Papers

White matter degeneration in subjective cognitive decline: a diffusion tensor imaging study

White matter degeneration in subjective cognitive decline: a diffusion tensor imaging study

https://doi.org/10.18632/oncotarget.10091

Xuan-yu Li, Zhen-chao Tang, Yu Sun, Jie Tian, Zhen-yu Liu,  and Ying Han
54405-54414
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Downregulation of the neonatal Fc receptor expression in non-small cell lung cancer tissue is associated with a poor prognosis

Downregulation of the neonatal Fc receptor expression in non-small cell lung cancer tissue is associated with a poor prognosis

https://doi.org/10.18632/oncotarget.10074

Emilie Dalloneau, Nadine Baroukh, Konstantinos Mavridis, Agnès Maillet, Fabien Gueugnon, Yves Courty, Agnès Petit, Thomas Kryza, Maguy Del Rio, Serge Guyetant, Diana Carolina Cadena Castaneda, Christine Dhommée, Christophe Arnoult, Andreas Scorilas, Valérie Gouilleux-Gruart,  and Nathalie Heuzé-Vourc’h
54415-54429
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Scaffold attachment factor A (SAF-A) and Ku temporally regulate repair of radiation-induced clustered genome lesions

Scaffold attachment factor A (SAF-A) and Ku temporally regulate repair of radiation-induced clustered genome lesions

https://doi.org/10.18632/oncotarget.9914

Muralidhar L. Hegde, Arijit Dutta, Chunying Yang, Anil K. Mantha, Pavana M. Hegde, Arvind Pandey, Shiladitya Sengupta, Yaping Yu, Patrick Calsou, David Chen, Susan P. Lees-Miller,  and Sankar Mitra
54430-54444
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Importance of the type I insulin-like growth factor receptor in HER2, FGFR2 and MET-unamplified gastric cancer with and without Ras pathway activation

Importance of the type I insulin-like growth factor receptor in HER2, FGFR2 and MET-unamplified gastric cancer with and without Ras pathway activation

https://doi.org/10.18632/oncotarget.10642

Marina Saisana, S. Michael Griffin,  and Felicity E.B. May
54445-54462
Abstract  |  PDF  |  HTML  |  Order a Reprint

Polypeptide N-acetylgalactosaminyltransferase-6 expression independently predicts poor overall survival in patients with lung adenocarcinoma after curative resection

Polypeptide N-acetylgalactosaminyltransferase-6 expression independently predicts poor overall survival in patients with lung adenocarcinoma after curative resection

https://doi.org/10.18632/oncotarget.9810

Zhi Li, Sohsuke Yamada, Ying Wu, Ke-Yong Wang, Yun-Peng Liu, Hidetaka Uramoto, Kimitoshi Kohno,  and Yasuyuki Sasaguri
54463-54473
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The urokinase receptor-derived cyclic peptide [SRSRY] suppresses neovascularization and intravasation of osteosarcoma and chondrosarcoma cells

The urokinase receptor-derived cyclic peptide [SRSRY] suppresses neovascularization and intravasation of osteosarcoma and chondrosarcoma cells

https://doi.org/10.18632/oncotarget.9976

Vincenzo Ingangi, Katia Bifulco, Ali Munaim Yousif, Concetta Ragone, Maria Letizia Motti, Domenica Rea, Michele Minopoli, Giovanni Botti, Giuseppe Scognamiglio, Flavio Fazioli, Michele Gallo, Annarosaria De Chiara, Claudio Arra, Paolo Grieco,  and Maria Vincenza Carriero
54474-54487
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Prognostic significance of PLIN1 expression in human breast cancer

Prognostic significance of PLIN1 expression in human breast cancer

https://doi.org/10.18632/oncotarget.10239

Cefan Zhou, Ming Wang, Li Zhou, Yi Zhang, Weiyong Liu, Wenying Qin, Rong He, Yang Lu, Yefu Wang, Xing-Zhen Chen,  and Jingfeng Tang
54488-54502
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

miRNA-193a-5p repression of p73 controls Cisplatin chemoresistance in primary bone tumors

miRNA-193a-5p repression of p73 controls Cisplatin chemoresistance in primary bone tumors

https://doi.org/10.18632/oncotarget.10950

Camille Jacques, Lidia Rodriguez Calleja, Marc Baud’huin, Thibaut Quillard, Dominique Heymann, François Lamoureux,  and Benjamin Ory
54503-54514
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Crizotinib inhibits NF2-associated schwannoma through inhibition of focal adhesion kinase 1

Crizotinib inhibits NF2-associated schwannoma through inhibition of focal adhesion kinase 1

https://doi.org/10.18632/oncotarget.10248

Scott Troutman, Susana Moleirinho, Smitha Kota, Kendall Nettles, Mohammad Fallahi, Gary L. Johnson,  and Joseph L. Kissil
54515-54525
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Targeted next generation sequencing of endoscopic ultrasound acquired cytology from ampullary and pancreatic adenocarcinoma has the potential to aid patient stratification for optimal therapy selection

Targeted next generation sequencing of endoscopic ultrasound acquired cytology from ampullary and pancreatic adenocarcinoma has the potential to aid patient stratification for optimal therapy selection

https://doi.org/10.18632/oncotarget.9440

Ferga C. Gleeson, Sarah E. Kerr, Benjamin R. Kipp, Jesse S. Voss, Douglas M. Minot, Zheng Jin Tu, Michael R. Henry, Rondell P. Graham, George Vasmatzis, John C. Cheville, Konstantinos N. Lazaridis,  and Michael J. Levy
54526-54536
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Induction of apoptosis and autophagy via mitochondria- and PI3K/Akt/mTOR-mediated pathways by E. adenophorum in hepatocytes of saanen goat

Induction of apoptosis and autophagy via mitochondria- and PI3K/Akt/mTOR-mediated pathways by E. adenophorum in hepatocytes of saanen goat

https://doi.org/10.18632/oncotarget.10402

Yajun He, Quan Mo, Biao Luo, Yan Qiao, Ruiguang Xu, Zhicai Zuo, Xiang Nong, Junliang Deng, Guangneng Peng, Wei He, Yahui Wei,  and Yanchun Hu
54537-54548
Abstract  |  PDF  |  HTML  |  Order a Reprint

Artificial small RNA for sequence specific cleavage of target RNA through RNase III endonuclease Dicer

Artificial small RNA for sequence specific cleavage of target RNA through RNase III endonuclease Dicer

https://doi.org/10.18632/oncotarget.9582

Wen Xu, Yuchen Liu, Yali Liu, Li Liu, Yonghao Zhan, Chengle Zhuang, Junhao Lin, Mingwei Chen, Jianfa Li, Zhiming Cai, Weiren Huang,  and Yong Zhang
54549-54554
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Independent evaluation of a FOXM1-based quantitative malignancy diagnostic system (qMIDS) on head and neck squamous cell carcinomas

Independent evaluation of a FOXM1-based quantitative malignancy diagnostic system (qMIDS) on head and neck squamous cell carcinomas

https://doi.org/10.18632/oncotarget.10512

Hong Ma, Haiyan Dai, Xiaofeng Duan, Zhenglong Tang, Rui Liu, Kunjun Sun, Ke Zhou, Hao Chen, Hang Xiang, Jinsheng Wang, Qiong Gao, Yuan Zou, Hong Wan,  and Muy-Teck Teh
54555-54563
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Systemic immune-inflammation index predicts the clinical outcome in patients with metastatic renal cell cancer treated with sunitinib

Systemic immune-inflammation index predicts the clinical outcome in patients with metastatic renal cell cancer treated with sunitinib

https://doi.org/10.18632/oncotarget.10515

Cristian Lolli, Umberto Basso, Lisa Derosa, Emanuela Scarpi, Teodoro Sava, Matteo Santoni, Simon J. Crabb, Francesco Massari, Michele Aieta, Vincenza Conteduca, Marco Maruzzo, Francesca La Russa, Matthew Wheater, Rossana Berardi, Luca Galli,  and Ugo De Giorgi
54564-54571
Abstract  |  PDF  |  HTML  |  Order a Reprint

Post-transcriptional knowledge in pathway analysis increases the accuracy of phenotypes classification

Post-transcriptional knowledge in pathway analysis increases the accuracy of phenotypes classification

https://doi.org/10.18632/oncotarget.9788

Salvatore Alaimo, Rosalba Giugno, Mario Acunzo, Dario Veneziano, Alfredo Ferro,  and Alfredo Pulvirenti
54572-54582
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Preclinical evaluation of potential therapeutic targets in dedifferentiated liposarcoma

Preclinical evaluation of potential therapeutic targets in dedifferentiated liposarcoma

https://doi.org/10.18632/oncotarget.10518

Robert Hanes, Iwona Grad, Susanne Lorenz, Eva W. Stratford, Else Munthe, Chilamakuri Chandra Sekhar Reddy, Leonardo A. Meza-Zepeda,  and Ola Myklebost
54583-54595
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The down-regulated ING5 expression in lung cancer: A potential target of gene therapy

The down-regulated ING5 expression in lung cancer: A potential target of gene therapy

https://doi.org/10.18632/oncotarget.10519

Shuang Zhao, Xue-feng Yang, Dao-fu Shen, Yang Gao, Shuai Shi, Ji-cheng Wu, Hong-xu Liu, Hong-zhi Sun, Rong-jian Su,  and Hua-chuan Zheng
54596-54615
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Identification and validation of regulatory SNPs that modulate transcription factor chromatin binding and gene expression in prostate cancer

Identification and validation of regulatory SNPs that modulate transcription factor chromatin binding and gene expression in prostate cancer

https://doi.org/10.18632/oncotarget.10520

Hong-Jian Jin, Segun Jung, Auditi R. DebRoy,  and Ramana V. Davuluri
54616-54626
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MET amplification in metastatic colorectal cancer: an acquired response to EGFR inhibition, not a de novo phenomenon

MET amplification in metastatic colorectal cancer: an acquired response to EGFR inhibition, not a de novo phenomenon

https://doi.org/10.18632/oncotarget.10559

Kanwal Raghav, Van Morris, Chad Tang, Pia Morelli, Hesham M. Amin, Ken Chen, Ganiraju C. Manyam, Bradley Broom, Michael J. Overman, Kenna Shaw, Funda Meric-Bernstam, Dipen Maru, David Menter, Lee M. Ellis, Cathy Eng, David Hong,  and Scott Kopetz
54627-54631
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Annexin 2A sustains glioblastoma cell dissemination and proliferation

Annexin 2A sustains glioblastoma cell dissemination and proliferation

https://doi.org/10.18632/oncotarget.10565

Francesca Maule, Silvia Bresolin, Elena Rampazzo, Daniele Boso, Alessandro Della Puppa, Giovanni Esposito, Elena Porcù, Stefania Mitola, Giuseppe Lombardi, Benedetta Accordi, Manuela Tumino, Giuseppe Basso,  and Luca Persano
54632-54649
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Specific patterns of PIWI-interacting small noncoding RNA expression in dysplastic liver nodules and hepatocellular carcinoma

Specific patterns of PIWI-interacting small noncoding RNA expression in dysplastic liver nodules and hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.10567

Francesca Rizzo, Antonio Rinaldi, Giovanna Marchese, Elena Coviello, Assunta Sellitto, Angela Cordella, Giorgio Giurato, Giovanni Nassa, Maria Ravo, Roberta Tarallo, Luciano Milanesi, Anna Destro, Guido Torzilli, Massimo Roncalli, Luca Di Tommaso,  and Alessandro Weisz
54650-54661
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Surgical resection and radiofrequency ablation initiate cancer in cytokeratin-19+- liver cells deficient for p53 and Rb

Surgical resection and radiofrequency ablation initiate cancer in cytokeratin-19+- liver cells deficient for p53 and Rb

https://doi.org/10.18632/oncotarget.9952

Ramadhan B. Matondo, Mathilda J.M. Toussaint, Klaas M. Govaert, Luciel D. van Vuuren, Sathidpak Nantasanti, Maarten W. Nijkamp, Shusil K. Pandit, Peter C.J. Tooten, Mirjam H. Koster, Kaylee Holleman, Arend Schot, Guoqiang Gu, Bart Spee, Tania Roskams, Inne Borel Rinkes, Baukje Schotanus, Onno Kranenburg,  and Alain de Bruin
54662-54675
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Circulating exosomes potentiate tumor malignant properties in a mouse model of chronic sleep fragmentation

Circulating exosomes potentiate tumor malignant properties in a mouse model of chronic sleep fragmentation

https://doi.org/10.18632/oncotarget.10578

Abdelnaby Khalyfa, Isaac Almendros, Alex Gileles-Hillel, Mahzad Akbarpour, Wojciech Trzepizur, Babak Mokhlesi, Lei Huang, Jorge Andrade, Ramon Farré,  and David Gozal
54676-54690
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Glutamine deprivation plus BPTES alters etoposide- and cisplatin-induced apoptosis in triple negative breast cancer cells

Glutamine deprivation plus BPTES alters etoposide- and cisplatin-induced apoptosis in triple negative breast cancer cells

https://doi.org/10.18632/oncotarget.10579

Lian Chen, Hengmin Cui, Jing Fang, Huidan Deng, Ping Kuang, Hongrui Guo, Xun Wang,  and Ling Zhao
54691-54701
Abstract  |  PDF  |  HTML  |  Order a Reprint

Gallic acid inhibition of Src-Stat3 signaling overcomes acquired resistance to EGF receptor tyrosine kinase inhibitors in advanced non-small cell lung cancer

Gallic acid inhibition of Src-Stat3 signaling overcomes acquired resistance to EGF receptor tyrosine kinase inhibitors in advanced non-small cell lung cancer

https://doi.org/10.18632/oncotarget.10581

Ai N.H. Phan, Tuyen N.M. Hua, Min-Kyu Kim, Vu T.A. Vo, Jong-Whan Choi, Hyun-Won Kim, Jin Kyung Rho, Ki Woo Kim,  and Yangsik Jeong
54702-54713
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

HDAC6 inhibition prevents TNF-α-induced caspase 3 activation in lung endothelial cell and maintains cell-cell junctions

HDAC6 inhibition prevents TNF-α-induced caspase 3 activation in lung endothelial cell and maintains cell-cell junctions

https://doi.org/10.18632/oncotarget.10591

Jinyan Yu, Mengshi Ma, Zhongsen Ma,  and Jian Fu
54714-54722
Abstract  |  PDF  |  HTML  |  Order a Reprint

Inhibition of primary breast tumor growth and metastasis using a neuropilin-1 transmembrane domain interfering peptide

Inhibition of primary breast tumor growth and metastasis using a neuropilin-1 transmembrane domain interfering peptide

https://doi.org/10.18632/oncotarget.10101

Alexia Arpel, Coralie Gamper, Caroline Spenlé, Aurore Fernandez, Laurent Jacob, Nadège Baumlin, Patrice Laquerriere, Gertraud Orend, Gérard Crémel,  and Dominique Bagnard
54723-54732
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MALAT1 promotes osteosarcoma development by targeting TGFA via MIR376A

MALAT1 promotes osteosarcoma development by targeting TGFA via MIR376A

https://doi.org/10.18632/oncotarget.10752

Wei Luo, Hongbo He, Wenfeng Xiao, Qing Liu, Zhenhan Deng, Yaojuan Lu, Qian Wang, Qiping Zheng,  and Yusheng Li
54733-54743
Abstract  |  PDF  |  HTML  |  Order a Reprint

PAX3 is a novel tumor suppressor by regulating the activities of major signaling pathways and transcription factor FOXO3a in thyroid cancer

PAX3 is a novel tumor suppressor by regulating the activities of major signaling pathways and transcription factor FOXO3a in thyroid cancer

https://doi.org/10.18632/oncotarget.10753

Wei Liu, Fang Sui, Jiazhe Liu, Meichen Wang, Sijia Tian, Meiju Ji, Bingyin Shi,  and Peng Hou
54744-54757
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Comprehensive assessment of the expression of the SWI/SNF complex defines two distinct prognostic subtypes of ovarian clear cell carcinoma

Comprehensive assessment of the expression of the SWI/SNF complex defines two distinct prognostic subtypes of ovarian clear cell carcinoma

https://doi.org/10.18632/oncotarget.10181

Hisham Abou-Taleb, Ken Yamaguchi, Noriomi Matsumura, Ryusuke Murakami, Hidekatsu Nakai, Koichiro Higasa, Yasuaki Amano, Kaoru Abiko, Yumiko Yoshioka, Junzo Hamanishi, Masafumi Koshiyama, Tsukasa Baba, Ryo Yamada, Fumihiko Matsuda, Ikuo Konishi,  and Masaki Mandai
54758-54770
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Association between single nucleotide polymorphisms in the TSPYL6 gene and breast cancer susceptibility in the Han Chinese population

Association between single nucleotide polymorphisms in the TSPYL6 gene and breast cancer susceptibility in the Han Chinese population

https://doi.org/10.18632/oncotarget.10754

Ming Liu, Bin Li, Wen Guo, Xiyang Zhang, Zhengshuai Chen, Jingjie Li, Mengdan Yan, Chao Chen,  and Tianbo Jin
54771-54781
Abstract  |  PDF  |  HTML  |  Order a Reprint

Cooperation between AlphavBeta3 integrin and the fibroblast growth factor receptor enhances proliferation of Hox-overexpressing acute myeloid leukemia cells

Cooperation between AlphavBeta3 integrin and the fibroblast growth factor receptor enhances proliferation of Hox-overexpressing acute myeloid leukemia cells

https://doi.org/10.18632/oncotarget.10189

Chirag A. Shah, Ling Bei, Hao Wang, Jessica K. Altman, Leonidas C. Platanias,  and Elizabeth A. Eklund
54782-54794
Abstract  |  PDF  |  HTML  |  Order a Reprint

Hypoxia-targeted 131I therapy of hepatocellular cancer after systemic mesenchymal stem cell-mediated sodium iodide symporter gene delivery

Hypoxia-targeted 131I therapy of hepatocellular cancer after systemic mesenchymal stem cell-mediated sodium iodide symporter gene delivery

https://doi.org/10.18632/oncotarget.10758

Andrea M. Müller, Kathrin A. Schmohl, Kerstin Knoop, Christina Schug, Sarah Urnauer, Anna Hagenhoff, Dirk-André Clevert, Michael Ingrisch, Hanno Niess, Janette Carlsen, Christian Zach, Ernst Wagner, Peter Bartenstein, Peter J. Nelson,  and Christine Spitzweg
54795-54810
Abstract  |  PDF  |  HTML  |  Order a Reprint

Regression of experimental NIS-expressing breast cancer brain metastases in response to radioiodide/gemcitabine dual therapy

Regression of experimental NIS-expressing breast cancer brain metastases in response to radioiodide/gemcitabine dual therapy

https://doi.org/10.18632/oncotarget.10238

Corinne Renier, John Do, Andrea Reyna-Neyra, Deshka Foster, Abhijit De, Hannes Vogel, Stefanie S. Jeffrey, Victor Tse, Nancy Carrasco,  and Irene Wapnir
54811-54824
Abstract  |  PDF  |  HTML  |  Order a Reprint

Mutation profiling of 19 candidate genes in acute myeloid leukemia suggests significance of DNMT3A mutations

Mutation profiling of 19 candidate genes in acute myeloid leukemia suggests significance of DNMT3A mutations

https://doi.org/10.18632/oncotarget.10240

Sang-Yong Shin, Seung-Tae Lee, Hee-Jin Kim, Eun Hae Cho, Jong-Won Kim, Silvia Park, Chul Won Jung,  and Sun-Hee Kim
54825-54837
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MiR-34b-3 and miR-449a inhibit malignant progression of nasopharyngeal carcinoma by targeting lactate dehydrogenase A

MiR-34b-3 and miR-449a inhibit malignant progression of nasopharyngeal carcinoma by targeting lactate dehydrogenase A

https://doi.org/10.18632/oncotarget.10761

Huiling Li, Xiaoling Li, Xiaolu Ge, Liqing Jia, Zhezhe Zhang, Renpeng Fang, Jing Yang, Jianpin Liu, Shuping Peng, Ming Zhou, Juanjuan Xiang, Zhaoyang Zeng, Wen Zhou, Wei Xiong, Gaoming Xiao, Li Fang, Gui-yuan Li,  and Zheng Li
54838-54851
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Lung cancer exosomes as drivers of epithelial mesenchymal transition

Lung cancer exosomes as drivers of epithelial mesenchymal transition

https://doi.org/10.18632/oncotarget.10243

Mohammad A. Rahman, Jennifer F. Barger, Francesca Lovat, Min Gao, Gregory A. Otterson,  and Patrick Nana-Sinkam
54852-54866
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Genomic similarity between gastroesophageal junction and esophageal Barrett’s adenocarcinomas

Genomic similarity between gastroesophageal junction and esophageal Barrett’s adenocarcinomas

https://doi.org/10.18632/oncotarget.10253

Daysha Ferrer-Torres, Derek J. Nancarrow, Rork Kuick, Dafydd G. Thomas, Ernest Nadal, Jules Lin, Andrew C. Chang, Rishindra M. Reddy, Mark B. Orringer, Jeremy M. G. Taylor, Thomas D. Wang,  and David G. Beer
54867-54882
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

FoxO proteins or loss of functional p53 maintain stemness of glioblastoma stem cells and survival after ionizing radiation plus PI3K/mTOR inhibition

FoxO proteins or loss of functional p53 maintain stemness of glioblastoma stem cells and survival after ionizing radiation plus PI3K/mTOR inhibition

https://doi.org/10.18632/oncotarget.10702

Elke Firat,  and Gabriele Niedermann
54883-54896
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

PIM kinases as therapeutic targets against advanced melanoma

PIM kinases as therapeutic targets against advanced melanoma

https://doi.org/10.18632/oncotarget.10703

Batool Shannan, Andrea Watters, Quan Chen, Stefan Mollin, Markus Dörr, Eric Meggers, Xiaowei Xu, Phyllis A. Gimotty, Michela Perego, Ling Li, Joseph Benci, Clemens Krepler, Patricia Brafford, Jie Zhang, Zhi Wei, Gao Zhang, Qin Liu, Xiangfan Yin, Katherine L. Nathanson, Meenhard Herlyn,  and Adina Vultur
54897-54912
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MIEN1 drives breast tumor cell migration by regulating cytoskeletal-focal adhesion dynamics

MIEN1 drives breast tumor cell migration by regulating cytoskeletal-focal adhesion dynamics

https://doi.org/10.18632/oncotarget.10798

Marilyne Kpetemey, Pankaj Chaudhary, Timothy Van Treuren,  and Jamboor K. Vishwanatha
54913-54924
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Photoimmunotheranostic agents for triple-negative breast cancer diagnosis and therapy that can be activated on demand

Photoimmunotheranostic agents for triple-negative breast cancer diagnosis and therapy that can be activated on demand

https://doi.org/10.18632/oncotarget.10705

Manal Amoury, Dirk Bauerschlag, Felix Zeppernick, Verena von Felbert, Nina Berges, Stefano Di Fiore, Isabell Mintert, Andreas Bleilevens, Nicolai Maass, Karen Bräutigam, Ivo Meinhold-Heerlein, Elmar Stickeler, Stefan Barth, Rainer Fischer,  and Ahmad Fawzi Hussain
54925-54936
Abstract  |  PDF  |  HTML  |  Order a Reprint

MYCN promotes neuroblastoma malignancy by establishing a regulatory circuit with transcription factor AP4

MYCN promotes neuroblastoma malignancy by establishing a regulatory circuit with transcription factor AP4

https://doi.org/10.18632/oncotarget.10709

Chengyuan Xue, Denise M.T. Yu, Samuele Gherardi, Jessica Koach, Giorgio Milazzo, Laura Gamble, Bing Liu, Emanuele Valli, Amanda J. Russell, Wendy B. London, Tao Liu, Belamy B. Cheung, Glenn M. Marshall, Giovanni Perini, Michelle Haber,  and Murray D. Norris
54937-54951
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Tumor growth accelerated by chemotherapy-induced senescent cells is suppressed by treatment with IL-12 producing cellular vaccines

Tumor growth accelerated by chemotherapy-induced senescent cells is suppressed by treatment with IL-12 producing cellular vaccines

https://doi.org/10.18632/oncotarget.10712

Jana Simova, Olena Sapega, Terezie Imrichova, Ivan Stepanek, Lenka Kyjacova, Romana Mikyskova, Marie Indrova, Jana Bieblova, Jan Bubenik, Jiri Bartek, Zdenek Hodny,  and Milan Reinis
54952-54964
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Plasma MiRNA alterations between NSCLC patients harboring Del19 and L858R EGFR mutations

Plasma MiRNA alterations between NSCLC patients harboring Del19 and L858R EGFR mutations

https://doi.org/10.18632/oncotarget.10829

Yihan Ma, Peiqi Xu, Yanjun Mi, Wenyi Wang, Xiaoyan Pan, Xiaoting Wu, Qi He, Hongming Liu, Weiwei Tang,  and Hanxiang An
54965-54972
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Expression of CDX2 in gastric cardia adenocarcinoma and its correlation with H. pylori and cell proliferation

Expression of CDX2 in gastric cardia adenocarcinoma and its correlation with H. pylori and cell proliferation

https://doi.org/10.18632/oncotarget.10362

Ying Zhang, Hu Wang, Chao Bi, Yinping Xiao,  and Zhaoyong Liu
54973-54982
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

NHERF1, a novel GPER associated protein, increases stability and activation of GPER in ER-positive breast cancer

NHERF1, a novel GPER associated protein, increases stability and activation of GPER in ER-positive breast cancer

https://doi.org/10.18632/oncotarget.10713

Ran Meng, Qiong Qin, Ying Xiong, Yan Wang, Junfang Zheng, Yuan Zhao, Tao Tao, Qiqi Wang, Hua Liu, Songlin Wang, Wen G. Jiang,  and Junqi He
54983-54997
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MiR-328 targeting PIM-1 inhibits proliferation and migration of pulmonary arterial smooth muscle cells in PDGFBB signaling pathway

MiR-328 targeting PIM-1 inhibits proliferation and migration of pulmonary arterial smooth muscle cells in PDGFBB signaling pathway

https://doi.org/10.18632/oncotarget.10714

Zhengjiang Qian, Limin Zhang, Jidong Chen, Yanjiao Li, Kang Kang, Junle Qu, Zhiwei Wang, Yujia Zhai, Li Li,  and Deming Gou
54998-55011
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MiRSEA: Discovering the pathways regulated by dysfunctional MicroRNAs

MiRSEA: Discovering the pathways regulated by dysfunctional MicroRNAs

https://doi.org/10.18632/oncotarget.10839

Junwei Han, Siyao Liu, Yunpeng Zhang, Yanjun Xu, Ying Jiang, Chunlong Zhang, Chunquan Li,  and Xia Li
55012-55025
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

CNS germinomas are characterized by global demethylation, chromosomal instability and mutational activation of the Kit-, Ras/Raf/Erk- and Akt-pathways

CNS germinomas are characterized by global demethylation, chromosomal instability and mutational activation of the Kit-, Ras/Raf/Erk- and Akt-pathways

https://doi.org/10.18632/oncotarget.10392

Simone Laura Schulte, Andreas Waha, Barbara Steiger, Dorota Denkhaus, Evelyn Dörner, Gabriele Calaminus, Ivo Leuschner,  and Torsten Pietsch
55026-55042
Abstract  |  PDF  |  HTML  |  Order a Reprint

Adrenomedullin promotes the growth of pancreatic ductal adenocarcinoma through recruitment of myelomonocytic cells

Adrenomedullin promotes the growth of pancreatic ductal adenocarcinoma through recruitment of myelomonocytic cells

https://doi.org/10.18632/oncotarget.10393

Min Xu, Feifei Qi, Shaosen Zhang, Xuhui Ma, Shan Wang, Chunying Wang, Yan Fu,  and Yongzhang Luo
55043-55056
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Metformin increases PDH and suppresses HIF-1α under hypoxic conditions and induces cell death in oral squamous cell carcinoma

Metformin increases PDH and suppresses HIF-1α under hypoxic conditions and induces cell death in oral squamous cell carcinoma

https://doi.org/10.18632/oncotarget.10842

Talita Antunes Guimarães, Lucyana Conceição Farias, Eliane Sobrinho Santos, Carlos Alberto de Carvalho Fraga, Lissur Azevedo Orsini, Leandro de Freitas Teles, John David Feltenberger, Sabrina Ferreira de Jesus, Marcela Gonçalves de Souza, Sérgio Henrique Sousa Santos, Alfredo Maurício Batista de Paula, Ricardo Santiago Gomez,  and André Luiz Sena Guimarães
55057-55068
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Phenotypic and genetic heterogeneity of tumor tissue and circulating tumor cells in patients with metastatic castration-resistant prostate cancer: a report from the PETRUS prospective study

Phenotypic and genetic heterogeneity of tumor tissue and circulating tumor cells in patients with metastatic castration-resistant prostate cancer: a report from the PETRUS prospective study

https://doi.org/10.18632/oncotarget.10396

Christophe Massard, Marianne Oulhen, Sylvestre Le Moulec, Nathalie Auger, Stéphanie Foulon, Aurélie Abou-Lovergne, Fanny Billiot, Alexander Valent, Virginie Marty, Yohann Loriot, Karim Fizazi, Philippe Vielh,  and Francoise Farace
55069-55082
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MLN0128, a novel mTOR kinase inhibitor, disrupts survival signaling and triggers apoptosis in AML and AML stem/ progenitor cells

MLN0128, a novel mTOR kinase inhibitor, disrupts survival signaling and triggers apoptosis in AML and AML stem/ progenitor cells

https://doi.org/10.18632/oncotarget.10397

Zhihong Zeng, Rui-Yu Wang, Yi Hua Qiu, Duncan H. Mak, Kevin Coombes, Suk Young Yoo, Qi Zhang, Katti Jessen, Yi Liu, Christian Rommel, David A. Fruman, Hagop M. Kantarjian, Steven M. Kornblau, Michael Andreeff,  and Marina Konopleva
55083-55097
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Tumor LINE-1 methylation level and colorectal cancer location in relation to patient survival

Tumor LINE-1 methylation level and colorectal cancer location in relation to patient survival

https://doi.org/10.18632/oncotarget.10398

Kosuke Mima, Jonathan A. Nowak, Zhi Rong Qian, Yin Cao, Mingyang Song, Yohei Masugi, Yan Shi, Annacarolina da Silva, Mancang Gu, Wanwan Li, Tsuyoshi Hamada, Xuehong Zhang, Kana Wu, Jeffrey A. Meyerhardt, Hideo Baba, Edward L. Giovannucci, Andrew T. Chan, Charles S. Fuchs, Shuji Ogino,  and Reiko Nishihara
55098-55109
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Carboxyl-terminal truncated HBx contributes to invasion and metastasis via deregulating metastasis suppressors in hepatocellular carcinoma

Carboxyl-terminal truncated HBx contributes to invasion and metastasis via deregulating metastasis suppressors in hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.10399

Weihua Li, Man Li, Dongjiang Liao, Xinpeng Lu, Xia Gu, Qianqian Zhang, Zhixiang Zhang,  and Hui Li
55110-55127
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MITF depletion elevates expression levels of ERBB3 receptor and its cognate ligand NRG1-beta in melanoma

MITF depletion elevates expression levels of ERBB3 receptor and its cognate ligand NRG1-beta in melanoma

https://doi.org/10.18632/oncotarget.10422

Tine N. Alver, Timothy J. Lavelle, Ane S. Longva, Geir F. Øy, Eivind Hovig,  and Sigurd L. Bøe
55128-55140
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Targeting αvβ3 and αvβ5 integrins inhibits pulmonary metastasis in an intratibial xenograft osteosarcoma mouse model

Targeting αvβ3 and αvβ5 integrins inhibits pulmonary metastasis in an intratibial xenograft osteosarcoma mouse model

https://doi.org/10.18632/oncotarget.10461

Ana Gvozdenovic, Aleksandar Boro, Daniela Meier, Beata Bode-Lesniewska, Walter Born, Roman Muff,  and Bruno Fuchs
55141-55154
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

High expression of intratumoral stromal proteins is associated with chemotherapy resistance in breast cancer

High expression of intratumoral stromal proteins is associated with chemotherapy resistance in breast cancer

https://doi.org/10.18632/oncotarget.10894

Tingting Wang, Supriya Srivastava, Mikael Hartman, Shaik Ahmad Buhari, Ching-Wan Chan, Philip Iau, Lay Wai Khin, Andrea Wong, Sing-Huang Tan, Boon-Cher Goh,  and Soo-Chin Lee
55155-55168
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Sex-specific clinicopathological significance of novel (Frizzled-7) and established (MGMT, IDH1) biomarkers in glioblastoma

Sex-specific clinicopathological significance of novel (Frizzled-7) and established (MGMT, IDH1) biomarkers in glioblastoma

https://doi.org/10.18632/oncotarget.10465

Salveena Schiffgens, Ludwig Wilkens, Alba A. Brandes, Tatiana Meier, Enrico Franceschi, Mario Ermani, Christian Hartmann, Ibrahim Erol Sandalcioglu,  and Claudia A. Dumitru
55169-55180
Abstract  |  PDF  |  HTML  |  Order a Reprint

Serum neuron-specific enolase levels are upregulated in patients with acute lymphoblastic leukemia and are predictive of prognosis

Serum neuron-specific enolase levels are upregulated in patients with acute lymphoblastic leukemia and are predictive of prognosis

https://doi.org/10.18632/oncotarget.10473

Cheng-cheng Liu, Hua Wang, Jing-hua Wang, Liang Wang, Qi-rong Geng, Xiao-qin Chen,  and Yue Lu
55181-55190
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

14-3-3ζ and aPKC-ι synergistically facilitate epithelial-mesenchymal transition of cholangiocarcinoma via GSK-3β/Snail signaling pathway

14-3-3ζ and aPKC-ι synergistically facilitate epithelial-mesenchymal transition of cholangiocarcinoma via GSK-3β/Snail signaling pathway

https://doi.org/10.18632/oncotarget.10483

Yan Yang, Yan Liu, Jun-chuang He, Jian-ming Wang, Peter Schemmer, Chao-qun Ma, Ya-wei Qian, Wei Yao, Jian Zhang, Wei-peng Qi, Yang Fu, Wei Feng,  and Tao Yang
55191-55210
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Nomogram and recursive partitioning analysis to predict overall survival in patients with stage IIB-III thoracic esophageal squamous cell carcinoma after esophagectomy

Nomogram and recursive partitioning analysis to predict overall survival in patients with stage IIB-III thoracic esophageal squamous cell carcinoma after esophagectomy

https://doi.org/10.18632/oncotarget.10904

Shufei Yu, Wencheng Zhang, Wenjie Ni, Zefen Xiao, Xin Wang, Zongmei Zhou, Qinfu Feng, Dongfu Chen, Jun Liang, Dekang Fang, Yousheng Mao, Shugeng Gao, Yexiong Li,  and Jie He
55211-55221
Abstract  |  PDF  |  HTML  |  Order a Reprint

Altered phenotypic and functional characteristics of CD3+CD56+ NKT-like cells in human gastric cancer

Altered phenotypic and functional characteristics of CD3+CD56+ NKT-like cells in human gastric cancer

https://doi.org/10.18632/oncotarget.10484

Liu-sheng Peng, Fang-yuan Mao, Yong-liang Zhao, Ting-ting Wang, Na Chen, Jin-yu Zhang, Ping Cheng, Wen-hua Li, Yi-pin Lv, Yong-sheng Teng, Gang Guo, Ping Luo, Weisan Chen, Quan-ming Zou,  and Yuan Zhuang
55222-55230
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Identification of a circulating microRNA signature to distinguish recurrence in breast cancer patients

Identification of a circulating microRNA signature to distinguish recurrence in breast cancer patients

https://doi.org/10.18632/oncotarget.10485

Dezheng Huo, Wendy M. Clayton, Toshio F. Yoshimatsu, Jianjun Chen,  and Olufunmilayo I. Olopade
55231-55248
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Meta-dimensional data integration identifies critical pathways for susceptibility, tumorigenesis and progression of endometrial cancer

Meta-dimensional data integration identifies critical pathways for susceptibility, tumorigenesis and progression of endometrial cancer

https://doi.org/10.18632/oncotarget.10509

Runmin Wei, Immaculata De Vivo, Sijia Huang, Xun Zhu, Harvey Risch, Jason H. Moore, Herbert Yu,  and Lana X. Garmire
55249-55263
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Somatic mutations predict outcomes of hypomethylating therapy in patients with myelodysplastic syndrome

Somatic mutations predict outcomes of hypomethylating therapy in patients with myelodysplastic syndrome

https://doi.org/10.18632/oncotarget.10526

Seung-Hyun Jung, Yoo-Jin Kim, Seon-Hee Yim, Hye-Jung Kim, Yong-Rim Kwon, Eun-Hye Hur, Bon-Kwan Goo, Yun-Suk Choi, Sug Hyung Lee, Yeun-Jun Chung,  and Je-Hwan Lee
55264-55275
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Expression of neural cell adhesion molecule L1 (CD171) in neuroectodermal and other tumors: An immunohistochemical study of 5155 tumors and critical evaluation of CD171 prognostic value in gastrointestinal stromal tumors

Expression of neural cell adhesion molecule L1 (CD171) in neuroectodermal and other tumors: An immunohistochemical study of 5155 tumors and critical evaluation of CD171 prognostic value in gastrointestinal stromal tumors

https://doi.org/10.18632/oncotarget.10527

Shingo Inaguma, Zengfeng Wang, Jerzy P. Lasota,  and Markku M. Miettinen
55276-55289
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

CEACAM6 is upregulated by Helicobacter pylori CagA and is a biomarker for early gastric cancer

CEACAM6 is upregulated by Helicobacter pylori CagA and is a biomarker for early gastric cancer

https://doi.org/10.18632/oncotarget.10528

Rony K. Roy, Michal M. Hoppe, Supriya Srivastava, Animesh Samanta, Neel Sharma, Kar Tong Tan, Henry Yang, Dominic C. Voon, Brendan Pang, Ming Teh, Naoko Murata-Kamiya, Masanori Hatakeyama, Young-Tae Chang, Wei Peng Yong, Yoshiaki Ito, Khek Yu Ho, Patrick Tan, Richie Soong, Phillip H. Koeffler, Khay Guan Yeoh,  and Anand D. Jeyasekharan
55290-55301
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Nucleophosmin leukemogenic mutant activates Wnt signaling during zebrafish development

Nucleophosmin leukemogenic mutant activates Wnt signaling during zebrafish development

https://doi.org/10.18632/oncotarget.10878

Elisa Barbieri, Gianluca Deflorian, Federica Pezzimenti, Debora Valli, Marco Saia, Natalia Meani, Alicja M. Gruszka,  and Myriam Alcalay
55302-55312
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The human Smoothened inhibitor PF-04449913 induces exit from quiescence and loss of multipotent Drosophila hematopoietic progenitor cells

The human Smoothened inhibitor PF-04449913 induces exit from quiescence and loss of multipotent Drosophila hematopoietic progenitor cells

https://doi.org/10.18632/oncotarget.10879

Giorgia Giordani, Marilena Barraco, Angela Giangrande, Giovanni Martinelli, Viviana Guadagnuolo, Giorgia Simonetti, Giovanni Perini,  and Roberto Bernardoni
55313-55327
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

CD109 is identified as a potential nasopharyngeal carcinoma biomarker using aptamer selected by cell-SELEX

CD109 is identified as a potential nasopharyngeal carcinoma biomarker using aptamer selected by cell-SELEX

https://doi.org/10.18632/oncotarget.10530

Wenting Jia, Caiping Ren, Lei Wang, Bin Zhu, Wei Jia, Menghui Gao, Fei Zeng, Liang Zeng, Xiaomeng Xia, Xiaobing Zhang, Ting Fu, Shasha Li, Can Du, Xingjun Jiang, Yuxiang Chen, Weihong Tan, Zilong Zhao,  and Weidong Liu
55328-55342
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A novel gene expression-based prognostic scoring system to predict survival in gastric cancer

A novel gene expression-based prognostic scoring system to predict survival in gastric cancer

https://doi.org/10.18632/oncotarget.10533

Pin Wang, Yunshan Wang, Bo Hang, Xiaoping Zou,  and Jian-Hua Mao
55343-55351
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Ranking novel cancer driving synthetic lethal gene pairs using TCGA data

Ranking novel cancer driving synthetic lethal gene pairs using TCGA data

https://doi.org/10.18632/oncotarget.10536

Hao Ye, Xiuhua Zhang, Yunqin Chen, Qi Liu,  and Jia Wei
55352-55367
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Incidence and origin of histologically confirmed liver metastases: an explorative case-study of 23,154 patients

Incidence and origin of histologically confirmed liver metastases: an explorative case-study of 23,154 patients

https://doi.org/10.18632/oncotarget.10552

Jannemarie de Ridder, Johannes H.W. de Wilt, Femke Simmer, Lucy Overbeek, Valery Lemmens,  and Iris Nagtegaal
55368-55376
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Identification of biomarkers for pseudo and true progression of GBM based on radiogenomics study

Identification of biomarkers for pseudo and true progression of GBM based on radiogenomics study

https://doi.org/10.18632/oncotarget.10553

Xiaohua Qian, Hua Tan, Jian Zhang, Keqin Liu, Tielin Yang, Maode Wang, Waldemar Debinskie, Weilin Zhao, Michael D. Chan,  and Xiaobo Zhou
55377-55394
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MicroRNA fingerprints in juvenile myelomonocytic leukemia (JMML) identified miR-150-5p as a tumor suppressor and potential target for treatment

MicroRNA fingerprints in juvenile myelomonocytic leukemia (JMML) identified miR-150-5p as a tumor suppressor and potential target for treatment

https://doi.org/10.18632/oncotarget.10577

Pier Paolo Leoncini, Alice Bertaina, Dimitrios Papaioannou, Christian Flotho, Riccardo Masetti, Silvia Bresolin, Giuseppe Menna, Nicola Santoro, Marco Zecca, Giuseppe Basso, Giovanni Nigita, Dario Veneziano, Sara Pagotto, Katia D’Ovidio, Rossella Rota, Adrienne Dorrance, Carlo M. Croce, Charlotte Niemeyer, Franco Locatelli,  and Ramiro Garzon
55395-55408
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

CD44v6-competent tumor exosomes promote motility, invasion and cancer-initiating cell marker expression in pancreatic and colorectal cancer cells

CD44v6-competent tumor exosomes promote motility, invasion and cancer-initiating cell marker expression in pancreatic and colorectal cancer cells

https://doi.org/10.18632/oncotarget.10580

Zhe Wang, Anja von Au, Martina Schnölzer, Thilo Hackert,  and Margot Zöller
55409-55436
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Prorenin receptor acts as a potential molecular target for pancreatic ductal adenocarcinoma diagnosis

Prorenin receptor acts as a potential molecular target for pancreatic ductal adenocarcinoma diagnosis

https://doi.org/10.18632/oncotarget.10583

Arivajiagane Arundhathi, Wen-Han Chuang, Jen-Kun Chen, Shin-E Wang, Yi-Ming Shyr, Jiun-Yu Chen, Wei-Neng Liao, Hsin-Wei Chen, Yi-Min Teng, Chiao-Chih Pai,  and Chih-Hong Wang
55437-55448
Abstract  |  PDF  |  HTML  |  Order a Reprint

ABCC2-24C > T polymorphism is associated with the response to platinum/5-Fu-based neoadjuvant chemotherapy and better clinical outcomes in advanced gastric cancer patients

ABCC2-24C > T polymorphism is associated with the response to platinum/5-Fu-based neoadjuvant chemotherapy and better clinical outcomes in advanced gastric cancer patients

https://doi.org/10.18632/oncotarget.10961

Ziyu Li, Xiaofang Xing, Fei Shan, Shuangxi Li, Zhongwu Li, Aitang Xiao, Zhaodong Xing, Kan Xue, Zhemin Li, Ying Hu, Yongning Jia, Rulin Miao, Lianhai Zhang, Zhaode Bu, Aiwen Wu,  and Jiafu Ji
55449-55457
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Thromboxane A2 receptor (TBXA2R) is a potent survival factor for triple negative breast cancers (TNBCs)

Thromboxane A2 receptor (TBXA2R) is a potent survival factor for triple negative breast cancers (TNBCs)

https://doi.org/10.18632/oncotarget.10969

Katy Orr, Niamh E. Buckley, Paula Haddock, Colin James, Jean-Luc Parent, Stephen McQuaid,  and Paul B. Mullan
55458-55472
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Monocyte-derived factors including PLA2G7 induced by macrophage-nasopharyngeal carcinoma cell interaction promote tumor cell invasiveness

Monocyte-derived factors including PLA2G7 induced by macrophage-nasopharyngeal carcinoma cell interaction promote tumor cell invasiveness

https://doi.org/10.18632/oncotarget.10980

Heng Boon Low, Chin Wen Png, Chunwei Li, De Yun Wang, Soon Boon Justin Wong,  and Yongliang Zhang
55473-55490
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Insulin-like growth factor binding protein-3 links obesity and breast cancer progression

Insulin-like growth factor binding protein-3 links obesity and breast cancer progression

https://doi.org/10.18632/oncotarget.10675

Tiffany Scully, Sue M. Firth, Carolyn D. Scott, Hasanthi C. de Silva, John E. Pintar, Tailoi Chan-Ling, Stephen M. Twigg,  and Robert C. Baxter
55491-55505
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Upregulation of brain-derived neurotrophic factor in advanced gastric cancer contributes to bone metastatic osteolysis by inducing long pentraxin 3

Upregulation of brain-derived neurotrophic factor in advanced gastric cancer contributes to bone metastatic osteolysis by inducing long pentraxin 3

https://doi.org/10.18632/oncotarget.10747

Bongkun Choi, Eun-Jin Lee, Min-Kyung Shin, Young Soo Park, Min-Hee Ryu, Sang-Min Kim, Eun-Young Kim, Hyung Keun Lee,  and Eun-Ju Chang
55506-55517
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Downregulated pseudogene CTNNAP1 promote tumor growth in human cancer by downregulating its cognate gene CTNNA1 expression

Downregulated pseudogene CTNNAP1 promote tumor growth in human cancer by downregulating its cognate gene CTNNA1 expression

https://doi.org/10.18632/oncotarget.10833

Xiangjian Chen, Hua Zhu, Xiaoli Wu, Xuemeng Xie, Guanli Huang, Xiaoqun Xu, Shi Li,  and Chungen Xing
55518-55528
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The application of mRNA-based gene transfer in mesenchymal stem cell-mediated cytotoxicity of glioma cells

The application of mRNA-based gene transfer in mesenchymal stem cell-mediated cytotoxicity of glioma cells

https://doi.org/10.18632/oncotarget.10835

Xing-Rong Guo, Zhuo-Shun Yang, Xiang-Jun Tang, Dan-Dan Zou, Hui Gui, Xiao-Li Wang, Shi-Nan Ma, Ya-Hong Yuan, Juan Fang, Bin Wang, Li Zhang, Xu-Yong Sun, Garth L. Warnock, Long-Jun Dai,  and Han-Jun Tu
55529-55542
Abstract  |  PDF  |  HTML  |  Order a Reprint

A FASN-TGF-β1-FASN regulatory loop contributes to high EMT/metastatic potential of cisplatin-resistant non-small cell lung cancer

A FASN-TGF-β1-FASN regulatory loop contributes to high EMT/metastatic potential of cisplatin-resistant non-small cell lung cancer

https://doi.org/10.18632/oncotarget.10837

Li Yang, Fuquan Zhang, Xin Wang, Ying Tsai, Kuang-Hsiang Chuang, Peter C. Keng, Soo Ok Lee,  and Yuhchyau Chen
55543-55554
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Targeting hyperactivated DNA-PKcs by KU0060648 inhibits glioma progression and enhances temozolomide therapy via suppression of AKT signaling

Targeting hyperactivated DNA-PKcs by KU0060648 inhibits glioma progression and enhances temozolomide therapy via suppression of AKT signaling

https://doi.org/10.18632/oncotarget.10864

Tian Lan, Zitong Zhao, Yanming Qu, Mingshan Zhang, Haoran Wang, Zhihua Zhang, Wei Zhou, Xinyi Fan, Chunjiang Yu, Qimin Zhan,  and Yongmei Song
55555-55571
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Integrin β3 and CD44 levels determine the effects of the OPN-a splicing variant on lung cancer cell growth

Integrin β3 and CD44 levels determine the effects of the OPN-a splicing variant on lung cancer cell growth

https://doi.org/10.18632/oncotarget.10865

Shih-Jung Sun, Chun-Chi Wu, Gwo-Tarng Sheu, Hui-Yi Chang, Mei-Yu Chen, Yu-Ying Lin, Cheng-Yen Chuang, Shih-Lan Hsu,  and Jinghua Tsai Chang
55572-55584
Abstract  |  PDF  |  HTML  |  Order a Reprint

YMO1 suppresses invasion and metastasis by inhibiting RhoC signaling and predicts favorable prognosis in hepatocellular carcinoma

YMO1 suppresses invasion and metastasis by inhibiting RhoC signaling and predicts favorable prognosis in hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.10866

Rui-Min Chang, Lei Pei, Feng Fang, Jiang-Feng Xu, Hao Yang, Chao-Hui Zuo, Jian-Hua Zhou, Geng-Qiu Luo,  and Lian-Yue Yang
55585-55600
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Decreased expression of FOXF2 as new predictor of poor prognosis in stage I non-small cell lung cancer

Decreased expression of FOXF2 as new predictor of poor prognosis in stage I non-small cell lung cancer

https://doi.org/10.18632/oncotarget.10876

Peng-Zhou Kong, Guang-Ming Li, Yin Tian, Bin Song,  and RuYi Shi
55601-55610
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The associations between MDM4 gene polymorphisms and cancer risk

The associations between MDM4 gene polymorphisms and cancer risk

https://doi.org/10.18632/oncotarget.10877

Ming-Jie Wang, Yong-Jun Luo, Zhi-Yong Shi, Xiao-Liang Xu, Guo-Liang Yao, Rui-Ping Liu,  and Hui Zhao
55611-55623
Abstract  |  PDF  |  HTML  |  Order a Reprint

Hypoxia-NOTCH1-SOX2 signaling is important for maintaining cancer stem cells in ovarian cancer

Hypoxia-NOTCH1-SOX2 signaling is important for maintaining cancer stem cells in ovarian cancer

https://doi.org/10.18632/oncotarget.10954

Eun Jin Seo, Dae Kyoung Kim, Il Ho Jang, Eun Jung Choi, Sang Hun Shin, Su In Lee, Sang-Mo Kwon, Ki-Hyung Kim, Dong-Soo Suh,  and Jae Ho Kim
55624-55638
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Constitutive gp130 activation rapidly accelerates the transformation of human hepatocytes via an impaired oxidative stress response

Constitutive gp130 activation rapidly accelerates the transformation of human hepatocytes via an impaired oxidative stress response

https://doi.org/10.18632/oncotarget.10956

Denise Heim, Ines Gil-Ibanez, Johannes Herden, Ann Christin Parplys, Kerstin Borgmann, Dirk Schmidt-Arras, Ansgar W. Lohse, Stefan Rose-John,  and Henning Wege
55639-55648
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

S18 family of mitochondrial ribosomal proteins: evolutionary history and Gly132 polymorphism in colon carcinoma

S18 family of mitochondrial ribosomal proteins: evolutionary history and Gly132 polymorphism in colon carcinoma

https://doi.org/10.18632/oncotarget.10957

Muhammad Mushtaq, Raja Hashim Ali, Vladimir Kashuba, George Klein,  and Elena Kashuba
55649-55662
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

CD24 promoted cancer cell angiogenesis via Hsp90-mediated STAT3/VEGF signaling pathway in colorectal cancer

CD24 promoted cancer cell angiogenesis via Hsp90-mediated STAT3/VEGF signaling pathway in colorectal cancer

https://doi.org/10.18632/oncotarget.10971

Xinying Wang, Yu Zhang, Yingying Zhao, Yanling Liang, Cheng Xiang, Huanyu Zhou, Hui Zhang, Qiang Zhang, Haitao Qing, Bo Jiang, Huabao Xiong,  and Liang Peng
55663-55676
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Epigenetic activation of LY6K predicts the presence of metastasis and poor prognosis in breast carcinoma

Epigenetic activation of LY6K predicts the presence of metastasis and poor prognosis in breast carcinoma

https://doi.org/10.18632/oncotarget.10972

Hyun Kyung Kong, Sae Jeong Park, Ye Sol Kim, Kyoung Min Kim, Hyun-Woo Lee, Hyeok-Gu Kang, Yu Mi Woo, Eun Young Park, Je Yeong Ko, Hiromu Suzuki, Kyung-Hee Chun, Erwei Song, Kyu Yun Jang,  and Jong Hoon Park
55677-55689
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Healthy CD4+ T lymphocytes are not affected by targeted therapies against the PI3K/Akt/mTOR pathway in T-cell acute lymphoblastic leukemia

Healthy CD4+ T lymphocytes are not affected by targeted therapies against the PI3K/Akt/mTOR pathway in T-cell acute lymphoblastic leukemia

https://doi.org/10.18632/oncotarget.10984

Ayman A.M. Alameen, Carolina Simioni, Alberto M. Martelli, Giorgio Zauli, Simona Ultimo, James A. McCubrey, Arianna Gonelli, Giorgia Marisi, Paola Ulivi, Silvano Capitani,  and Luca M. Neri
55690-55703
Abstract  |  PDF  |  HTML  |  Order a Reprint

The trans-membrane domain of Bcl-2α, but not its hydrophobic cleft, is a critical determinant for efficient IP3 receptor inhibition

The trans-membrane domain of Bcl-2α, but not its hydrophobic cleft, is a critical determinant for efficient IP3 receptor inhibition

https://doi.org/10.18632/oncotarget.11005

Hristina Ivanova, Abigael Ritane, Larry Wagner, Tomas Luyten, George Shapovalov, Kirsten Welkenhuyzen, Bruno Seitaj, Giovanni Monaco, Humbert De Smedt, Natalia Prevarskaya, David I. Yule, Jan B. Parys,  and Geert Bultynck
55704-55720
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Clinical Research Papers

Efficacy and safety of cisplatin, dexamethasone, gemcitabine and pegaspargase (DDGP) regimen in newly diagnosed, advanced-stage extranodal natural killer/T-cell lymphoma: interim analysis of a phase 4 study NCT01501149

Efficacy and safety of cisplatin, dexamethasone, gemcitabine and pegaspargase (DDGP) regimen in newly diagnosed, advanced-stage extranodal natural killer/T-cell lymphoma: interim analysis of a phase 4 study NCT01501149

https://doi.org/10.18632/oncotarget.10124

Lei Zhang, Sisi Jia, Yangyang Ma, Ling Li, Xin Li, Xinhua Wang, Xiaorui Fu, Wang Ma, Yanru Qin, Wencai Li, Jingjing Wu, Zhenchang Sun, Xudong Zhang, Feifei Nan, Yu Chang, Zhaoming Li, Dandan Zhang, Guannan Wang, Jiaqin Yan, Liping Su, Jinghua Wang, Hongwei Xue, Ken H. Young,  and Mingzhi Zhang
55721-55731
Abstract  |  PDF  |  HTML  |  Order a Reprint

Chemotherapy plus targeted drugs in conversion therapy for potentially resectable colorectal liver metastases: a meta-analysis

Chemotherapy plus targeted drugs in conversion therapy for potentially resectable colorectal liver metastases: a meta-analysis

https://doi.org/10.18632/oncotarget.9675

Lu Wang, Yinan Sun, Ben Zhao, Huixian Zhang, Qianqian Yu,  and Xianglin Yuan
55732-55740
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Pharmacogenomics of platinum-based chemotherapy response in NSCLC: a genotyping study and a pooled analysis

Pharmacogenomics of platinum-based chemotherapy response in NSCLC: a genotyping study and a pooled analysis

https://doi.org/10.18632/oncotarget.9688

Juan Chen, Zhan Wang, Ting Zou, Jiajia Cui, Jiye Yin, Wei Zheng, Wuzhong Jiang, Honghao Zhou,  and Zhaoqian Liu
55741-55756
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

TCF21 genetic polymorphisms and breast cancer risk in Chinese women

TCF21 genetic polymorphisms and breast cancer risk in Chinese women

https://doi.org/10.18632/oncotarget.9825

Xueren Gao, Jiaojiao Yang, Mingxi Wang,  and Jianqiong Zhang
55757-55764
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Elevated serum C-reactive protein level predicts a poor prognosis for recurrent gastric cancer

Elevated serum C-reactive protein level predicts a poor prognosis for recurrent gastric cancer

https://doi.org/10.18632/oncotarget.9910

Fanming Kong, Fangfang Gao, Jun Chen, Rongxiu Zheng, Honggen Liu, Xiaojiang Li, Peiying Yang, Geli Liu,  and Yingjie Jia
55765-55770
Abstract  |  PDF  |  HTML  |  Order a Reprint

Reviews

Targeting epithelial-mesenchymal transition and cancer stem cells for chemoresistant ovarian cancer

Targeting epithelial-mesenchymal transition and cancer stem cells for chemoresistant ovarian cancer

https://doi.org/10.18632/oncotarget.9908

Junli Deng, Li Wang, Hongmin Chen, Jingli Hao, Jie Ni, Lei Chang, Wei Duan, Peter Graham,  and Yong Li
55771-55788
Abstract  |  PDF  |  HTML  |  Order a Reprint

The multifaceted role of lysine acetylation in cancer: prognostic biomarker and therapeutic target

The multifaceted role of lysine acetylation in cancer: prognostic biomarker and therapeutic target

https://doi.org/10.18632/oncotarget.10048

Marta Di Martile, Donatella Del Bufalo,  and Daniela Trisciuoglio
55789-55810
Abstract  |  PDF  |  HTML  |  Order a Reprint

Sulfonation, an underexploited area: from skeletal development to infectious diseases and cancer

Sulfonation, an underexploited area: from skeletal development to infectious diseases and cancer

https://doi.org/10.18632/oncotarget.10046

Ada W.Y. Leung, Ian Backstrom,  and Marcel B. Bally
55811-55827
Abstract  |  PDF  |  HTML  |  Order a Reprint

Positive and negative functions of B lymphocytes in tumors

Positive and negative functions of B lymphocytes in tumors

https://doi.org/10.18632/oncotarget.10094

Meng Shen, Qian Sun, Jian Wang, Wei Pan,  and Xiubao Ren
55828-55839
Abstract  |  PDF  |  HTML  |  Order a Reprint

Endocannabinoid control of glutamate NMDA receptors: the therapeutic potential and consequences of dysfunction

Endocannabinoid control of glutamate NMDA receptors: the therapeutic potential and consequences of dysfunction

https://doi.org/10.18632/oncotarget.10095

María Rodríguez-Muñoz, Pilar Sánchez-Blázquez, Manuel Merlos,  and Javier Garzón-Niño
55840-55862
Abstract  |  PDF  |  HTML  |  Order a Reprint

Cytoplasmic vacuolization in cell death and survival

Cytoplasmic vacuolization in cell death and survival

https://doi.org/10.18632/oncotarget.10150

Andrey V. Shubin, Ilya V. Demidyuk, Alexey A. Komissarov, Lola M. Rafieva,  and Sergey V. Kostrov
55863-55889
Abstract  |  PDF  |  HTML  |  Order a Reprint

Prognostic value of amphiregulin and epiregulin mRNA expression in metastatic colorectal cancer patients

Prognostic value of amphiregulin and epiregulin mRNA expression in metastatic colorectal cancer patients

https://doi.org/10.18632/oncotarget.10151

Chen Jing, Yang Han Jin, Zhai You, Qian Qiong,  and Zhou Jun
55890-55899
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

miR-497 expression, function and clinical application in cancer

miR-497 expression, function and clinical application in cancer

https://doi.org/10.18632/oncotarget.10152

Gang Yang, Guangbing Xiong, Zhe Cao, Suli Zheng, Lei You, Taiping Zhang,  and Yupei Zhao
55900-55911
Abstract  |  PDF  |  HTML  |  Order a Reprint

A meta-analysis of alcohol consumption and thyroid cancer risk

A meta-analysis of alcohol consumption and thyroid cancer risk

https://doi.org/10.18632/oncotarget.10352

Xiaofei Wang, Wenli Cheng, Jingdong Li,  and Jingqiang Zhu
55912-55923
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

FGFR3-TACC3 fusion in solid tumors: mini review

FGFR3-TACC3 fusion in solid tumors: mini review

https://doi.org/10.18632/oncotarget.10482

Ricardo Costa, Benedito A. Carneiro, Timothy Taxter, Fabio A. Tavora, Aparna Kalyan, Sachin A. Pai, Young Kwang Chae,  and Francis J. Giles
55924-55938
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