Oncotarget

Vol 7, No 28

July 12, 2016

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TLR agonists plus chemotherapy eliminate advanced mouse cancers. See Manrique et al.

Table of Contents

Priority Research Papers

Multimodal targeting of tumor vasculature and cancer stem-like cells in sarcomas with VEGF-A inhibition, HIF-1α inhibition, and hypoxia-activated chemotherapy

Multimodal targeting of tumor vasculature and cancer stem-like cells in sarcomas with VEGF-A inhibition, HIF-1α inhibition, and hypoxia-activated chemotherapy

https://doi.org/10.18632/oncotarget.10212

Changhwan Yoon, Kevin K. Chang, Jun Ho Lee, William D. Tap, Charles P. Hart, M. Celeste Simon,  and Sam S. Yoon
42844-42858
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Integrated in vivo genetic and pharmacologic screening identifies co-inhibition of EGRF and ROCK as a potential treatment regimen for triple-negative breast cancer

Integrated in vivo genetic and pharmacologic screening identifies co-inhibition of EGRF and ROCK as a potential treatment regimen for triple-negative breast cancer

https://doi.org/10.18632/oncotarget.10230

Sedef Iskit, Cor Lieftink, Pasi Halonen, Aida Shahrabi, Patricia A. Possik, Roderick L. Beijersbergen,  and Daniel S. Peeper
42859-42872
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Research Papers: Gerotarget (Focus on Aging)

Do human B-lymphocytes avoid aging until 60 years?

Do human B-lymphocytes avoid aging until 60 years?

https://doi.org/10.18632/oncotarget.10146

Andrea Knight, Pavel Nemec, Sona Bretzova, Lucie Valkova, Marketa Kolmanova, Renata Vytopilova, Marek Havelka, Pavla Vsianska, Lucie Rihova, Marta Krejci,  and Martin Piskacek
42873-42880
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Baicalein is an available anti-atherosclerotic compound through modulation of nitric oxide-related mechanism under oxLDL exposure

Baicalein is an available anti-atherosclerotic compound through modulation of nitric oxide-related mechanism under oxLDL exposure

https://doi.org/10.18632/oncotarget.10263

Shih-Hung Chan, Ching-Hsia Hung, Jhih-Yuan Shih, Pei-Ming Chu, Yung-Hsin Cheng, Yi-Ju Tsai, Huei-Chen Lin,  and Kun-Ling Tsai
42881-42891
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Research Papers: Pathology

Protein inhibitor of activated STAT 4 (PIAS4) regulates pro-inflammatory transcription in hepatocytes by repressing SIRT1

Protein inhibitor of activated STAT 4 (PIAS4) regulates pro-inflammatory transcription in hepatocytes by repressing SIRT1

https://doi.org/10.18632/oncotarget.9864

Lina Sun, Zhiwen Fan, Junliang Chen, Wenfang Tian, Min Li, Huihui Xu, Xiaoyan Wu, Mingming Fang, Jun Xia,  and Yong Xu
42892-42903
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Tracing the origin of Treponema pallidum in China using next-generation sequencing

Tracing the origin of Treponema pallidum in China using next-generation sequencing

https://doi.org/10.18632/oncotarget.10154

Jun Sun, Zhefeng Meng, Kaiqi Wu, Biao Liu, Sufang Zhang, Yudan Liu, Yuezhu Wang, Huajun Zheng, Jian Huang,  and Pingyu Zhou
42904-42918
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Research Papers: Immunology

Definitive activation of endogenous antitumor immunity by repetitive cycles of cyclophosphamide with interspersed Toll-like receptor agonists

Definitive activation of endogenous antitumor immunity by repetitive cycles of cyclophosphamide with interspersed Toll-like receptor agonists

https://doi.org/10.18632/oncotarget.10190

Soraya Zorro Manrique, Ana L. Dominguez, Noweeda Mirza, Christopher D. Spencer, Judy M. Bradley, James H. Finke, James J. Lee, Larry R. Pease, Sandra J. Gendler,  and Peter A. Cohen
42919-42942
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Interview with Peter A. Cohen, M.D.  |  Order a Reprint

Persistent donor derived Vδ4 T cell clones may improve survival for recurrent T cell acute lymphoblastic leukemia after HSCT and DLI

Persistent donor derived Vδ4 T cell clones may improve survival for recurrent T cell acute lymphoblastic leukemia after HSCT and DLI

https://doi.org/10.18632/oncotarget.10260

Ling Xu, Jianyu Weng, Xin Huang, Chengwu Zeng, Shaohua Chen, Suxia Geng, Lijian Yang, Suijing Wu, Suming Huang, Xin Du,  and Yangqiu Li
42943-42952
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

IL-17 down-regulates the immunosuppressive capacity of olfactory ecto-mesenchymal stem cells in murine collagen-induced arthritis

IL-17 down-regulates the immunosuppressive capacity of olfactory ecto-mesenchymal stem cells in murine collagen-induced arthritis

https://doi.org/10.18632/oncotarget.10261

Jie Tian, Ke Rui, Xinyi Tang, Wenxin Wang, Jie Ma, Xinyu Tian, Yungang Wang, Huaxi Xu, Liwei Lu,  and Shengjun Wang
42953-42962
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In vitro studies implicate an imbalanced activation of dendritic cells in the pathogenesis of murine autoimmune pancreatitis

In vitro studies implicate an imbalanced activation of dendritic cells in the pathogenesis of murine autoimmune pancreatitis

https://doi.org/10.18632/oncotarget.10265

Luise Borufka, Erik Volmer, Sarah Müller, Robby Engelmann, Horst Nizze, Saleh Ibrahim,  and Robert Jaster
42963-42977
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Research Papers

High-density lipoprotein cholesterol as a predictor of poor survival in patients with nasopharyngeal carcinoma

High-density lipoprotein cholesterol as a predictor of poor survival in patients with nasopharyngeal carcinoma

https://doi.org/10.18632/oncotarget.7160

Yan-Yan Liu, Shao-Jun Lin, Yuan-Yuan Chen, Li-Na Liu, Liu-Bin Bao, Lin-Quan Tang, Jing-Song Ou, Zhi-Gang Liu, Xiao-Zhong Chen, Yan Xu, Jun Ma, Anthony T. Chan, Ming Chen, Yun-Fei Xia, Wan-Li Liu, Yi-Xin Zeng, Hai-Qiang Mai, Mu-Sheng Zeng, Jian-Ji Pan,  and Xing Zhang
42978-42987
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Liquid biopsy monitoring uncovers acquired RAS-mediated resistance to cetuximab in a substantial proportion of patients with head and neck squamous cell carcinoma

Liquid biopsy monitoring uncovers acquired RAS-mediated resistance to cetuximab in a substantial proportion of patients with head and neck squamous cell carcinoma

https://doi.org/10.18632/oncotarget.8943

Friederike Braig, Minna Voigtlaender, Aneta Schieferdecker, Chia-Jung Busch, Simon Laban, Tobias Grob, Malte Kriegs, Rainald Knecht, Carsten Bokemeyer,  and Mascha Binder
42988-42995
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A key role of GARP in the immune suppressive tumor microenvironment

A key role of GARP in the immune suppressive tumor microenvironment

https://doi.org/10.18632/oncotarget.9598

Susanne A. Hahn, Annemarie Neuhoff, Jenny Landsberg, Jonathan Schupp, Daniela Eberts, Petra Leukel, Matthias Bros, Martin Weilbaecher, Detlef Schuppan, Stephan Grabbe, Thomas Tueting, Volker Lennerz, Clemens Sommer, Helmut Jonuleit,  and Andrea Tuettenberg
42996-43009
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Tailored chemokine receptor modification improves homing of adoptive therapy T cells in a spontaneous tumor model

Tailored chemokine receptor modification improves homing of adoptive therapy T cells in a spontaneous tumor model

https://doi.org/10.18632/oncotarget.9280

Stefano Garetto, Claudia Sardi, Elisa Martini, Giuliana Roselli, Diego Morone, Roberta Angioni, Beatrice Claudia Cianciotti, Anna Elisa Trovato, Davide Giuseppe Franchina, Giovanni Francesco Castino, Debora Vignali, Marco Erreni, Federica Marchesi, Cristiano Rumio,  and Marinos Kallikourdis
43010-43026
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RIC versus MAC UCBT in adults with AML: A report from Eurocord, the ALWP and the CTIWP of the EBMT

RIC versus MAC UCBT in adults with AML: A report from Eurocord, the ALWP and the CTIWP of the EBMT

https://doi.org/10.18632/oncotarget.9599

Frédéric Baron, Annalisa Ruggeri, Eric Beohou, Myriam Labopin, Guillermo Sanz, Noel Milpied, Mauricette Michallet, Andrea Bacigalupo, Didier Blaise, Jorge Sierra, Gérard Socié, Jan J. Cornelissen, Christoph Schmid, Sebastian Giebel, Norbert-Claude Gorin, Jordi Esteve, Fabio Ciceri, Bipin N. Savani, Mohamad Mohty, Eliane Gluckman,  and Arnon Nagler
43027-43038
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Combination of radiotherapy and vaccination overcomes checkpoint blockade resistance

Combination of radiotherapy and vaccination overcomes checkpoint blockade resistance

https://doi.org/10.18632/oncotarget.9915

Wenxin Zheng, Kinga B. Skowron, Jukes P. Namm, Byron Burnette, Christian Fernandez, Ainhoa Arina, Hua Liang, Michael T. Spiotto, Mitchell C. Posner, Yang-Xin Fu,  and Ralph R. Weichselbaum
43039-43051
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The genetic landscape of dural marginal zone lymphomas

The genetic landscape of dural marginal zone lymphomas

https://doi.org/10.18632/oncotarget.9678

Karthik A. Ganapathi, Vaidehi Jobanputra, Fabio Iwamoto, Preti Jain, Jinli Chen, Luciano Cascione, Odelia Nahum, Brynn Levy, Yi Xie, Pallavi Khattar, Daniela Hoehn, Francesco Bertoni, Vundavalli V. Murty, Stefania Pittaluga, Elaine S. Jaffe, Bachir Alobeid, Mahesh M. Mansukhani,  and Govind Bhagat
43052-43061
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

BO-1055, a novel DNA cross-linking agent with remarkable low myelotoxicity shows potent activity in sarcoma models

BO-1055, a novel DNA cross-linking agent with remarkable low myelotoxicity shows potent activity in sarcoma models

https://doi.org/10.18632/oncotarget.9657

Srikanth R. Ambati, Jae-Hung Shieh, Benet Pera, Eloisi Caldas Lopes, Anisha Chaudhry, Elissa W.P. Wong, Ashish Saxena, Tsann-Long Su,  and Malcolm A.S. Moore
43062-43075
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Epithelial ovarian cancer-secreted exosomal miR-222-3p induces polarization of tumor-associated macrophages

Epithelial ovarian cancer-secreted exosomal miR-222-3p induces polarization of tumor-associated macrophages

https://doi.org/10.18632/oncotarget.9246

Xiang Ying, Quanfeng Wu, Xiaoli Wu, Qinyi Zhu, Xinjing Wang, Lu Jiang, Xin Chen,  and Xipeng Wang
43076-43087
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Importance of the residue 190 on bactericidal activity of the bactericidal/permeability-increasing protein 5

Importance of the residue 190 on bactericidal activity of the bactericidal/permeability-increasing protein 5

https://doi.org/10.18632/oncotarget.9292

Hanwei Wu, Lu Liu, Muqi Lin, Li Liu, Chen He, Duo Zheng,  and Weiren Huang
43088-43094
Abstract  |  PDF  |  HTML  |  Order a Reprint

Targeting glioma stem cells enhances anti-tumor effect of boron neutron capture therapy

Targeting glioma stem cells enhances anti-tumor effect of boron neutron capture therapy

https://doi.org/10.18632/oncotarget.9355

Ting Sun, Yanyan Li, Yulun Huang, Zizhu Zhang, Weilian Yang, Ziwei Du,  and Youxin Zhou
43095-43108
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Angiogenin contributes to bladder cancer tumorigenesis by DNMT3b-mediated MMP2 activation

Angiogenin contributes to bladder cancer tumorigenesis by DNMT3b-mediated MMP2 activation

https://doi.org/10.18632/oncotarget.10097

Rafael Peres, Hideki Furuya, Ian Pagano, Yoshiko Shimizu, Kanani Hokutan,  and Charles J. Rosser
43109-43123
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Wnt-beta-catenin pathway signals metastasis-associated tumor cell phenotypes in triple negative breast cancers

Wnt-beta-catenin pathway signals metastasis-associated tumor cell phenotypes in triple negative breast cancers

https://doi.org/10.18632/oncotarget.8988

Pradip De, Jennifer H. Carlson, Hui Wu, Adam Marcus, Brian Leyland-Jones,  and Nandini Dey
43124-43149
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Tunneling nanotube formation is stimulated by hypoxia in ovarian cancer cells

Tunneling nanotube formation is stimulated by hypoxia in ovarian cancer cells

https://doi.org/10.18632/oncotarget.9504

Snider Desir, Elizabeth L. Dickson, Rachel I. Vogel, Venugopal Thayanithy, Phillip Wong, Deanna Teoh, Melissa A. Geller, Clifford J. Steer, Subbaya Subramanian,  and Emil Lou
43150-43161
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Epigenetic modifications promote the expression of the orphan nuclear receptor NR0B1 in human lung adenocarcinoma cells

Epigenetic modifications promote the expression of the orphan nuclear receptor NR0B1 in human lung adenocarcinoma cells

https://doi.org/10.18632/oncotarget.9012

Yongjie Lu, Yunqiang Liu, Shunyao Liao, Wenling Tu, Ying Shen, Yuanlong Yan, Dachang Tao, Yilu Lu, Yongxin Ma, Yuan Yang,  and Sizhong Zhang
43162-43176
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Expression of the extracellular sulfatase SULF2 is associated with squamous cell carcinoma of the head and neck

Expression of the extracellular sulfatase SULF2 is associated with squamous cell carcinoma of the head and neck

https://doi.org/10.18632/oncotarget.9506

Sarah A. Flowers, Xin Zhou, Jing Wu, Yiwen Wang, Kepher Makambi, Bhaskar V. Kallakury, Mark S. Singer, Steven D. Rosen, Bruce Davidson,  and Radoslav Goldman
43177-43187
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The Hippo transducers TAZ/YAP and their target CTGF in male breast cancer

The Hippo transducers TAZ/YAP and their target CTGF in male breast cancer

https://doi.org/10.18632/oncotarget.9668

Anna Di Benedetto, Marcella Mottolese, Francesca Sperati, Cristiana Ercolani, Luigi Di Lauro, Laura Pizzuti, Patrizia Vici, Irene Terrenato, Isabella Sperduti, Abeer M. Shaaban, Sreekumar Sundara-Rajan, Maddalena Barba, Valerie Speirs, Ruggero De Maria,  and Marcello Maugeri-Saccà
43188-43198
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A novel HSP90 inhibitor with reduced hepatotoxicity synergizes with radiotherapy to induce apoptosis, abrogate clonogenic survival, and improve tumor control in models of colorectal cancer

A novel HSP90 inhibitor with reduced hepatotoxicity synergizes with radiotherapy to induce apoptosis, abrogate clonogenic survival, and improve tumor control in models of colorectal cancer

https://doi.org/10.18632/oncotarget.9774

Linda Kinzel, Anne Ernst, Michael Orth, Valerie Albrecht, Roman Hennel, Nikko Brix, Benjamin Frey, Udo S. Gaipl, Gabriele Zuchtriegel, Christoph A. Reichel, Andreas Blutke, Daniela Schilling, Gabriele Multhoff, Minglun Li, Maximilian Niyazi, Anna A. Friedl, Nicolas Winssinger, Claus Belka,  and Kirsten Lauber
43199-43219
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Phosphorylation of Notch1 by Pim kinases promotes oncogenic signaling in breast and prostate cancer cells

Phosphorylation of Notch1 by Pim kinases promotes oncogenic signaling in breast and prostate cancer cells

https://doi.org/10.18632/oncotarget.9215

Niina M. Santio, Sebastian K.J. Landor, Laura Vahtera, Jani Ylä-Pelto, Elina Paloniemi, Susumu Y. Imanishi, Garry Corthals, Markku Varjosalo, Ganesh Babu Manoharan, Asko Uri, Urban Lendahl, Cecilia Sahlgren,  and Päivi J. Koskinen
43220-43238
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Orai1 promotes tumor progression by enhancing cancer stemness via NFAT signaling in oral/oropharyngeal squamous cell carcinoma

Orai1 promotes tumor progression by enhancing cancer stemness via NFAT signaling in oral/oropharyngeal squamous cell carcinoma

https://doi.org/10.18632/oncotarget.9755

Sung Hee Lee, Nicole Kristina Rigas, Chang-Ryul Lee, April Bang, Sonal Srikanth, Yousang Gwack, Mo K. Kang, Reuben H. Kim, No-Hee Park,  and Ki-Hyuk Shin
43239-43255
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Xist reduction in breast cancer upregulates AKT phosphorylation via HDAC3-mediated repression of PHLPP1 expression

Xist reduction in breast cancer upregulates AKT phosphorylation via HDAC3-mediated repression of PHLPP1 expression

https://doi.org/10.18632/oncotarget.9673

Yen-Sung Huang, Che-Chang Chang, Szu-Shuo Lee, Yuh-Shan Jou,  and Hsiu-Ming Shih
43256-43266
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Human HLA-A*02:01/CHM1+ allo-restricted T cell receptor transgenic CD8+ T Cells specifically inhibit Ewing sarcoma growth in vitro and in vivo

Human HLA-A*02:01/CHM1+ allo-restricted T cell receptor transgenic CD8+ T Cells specifically inhibit Ewing sarcoma growth in vitro and in vivo

https://doi.org/10.18632/oncotarget.9218

Franziska Blaeschke, Uwe Thiel, Andreas Kirschner, Melanie Thiede, Rebeca Alba Rubio, David Schirmer, Thomas Kirchner, Günther H.S. Richter, Sabine Mall, Richard Klar, Stanley Riddell, Dirk H. Busch, Angela Krackhardt, Thomas G.P. Grunewald,  and Stefan Burdach
43267-43280
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Expression and functional characterization of CD33 transcript variants in human acute myeloid leukemia

Expression and functional characterization of CD33 transcript variants in human acute myeloid leukemia

https://doi.org/10.18632/oncotarget.9674

George S. Laszlo, Kimberly H. Harrington, Chelsea J. Gudgeon, Mary E. Beddoe, Matthew P. Fitzgibbon, Rhonda E. Ries, Jatinder K. Lamba, Martin W. McIntosh, Soheil Meshinchi,  and Roland B. Walter
43281-43294
Abstract  |  PDF  |  HTML  |  Order a Reprint

The role of Wnt/β-catenin signaling pathway in melanoma epithelial-to-mesenchymal-like switching: evidences from patients-derived cell lines

The role of Wnt/β-catenin signaling pathway in melanoma epithelial-to-mesenchymal-like switching: evidences from patients-derived cell lines

https://doi.org/10.18632/oncotarget.9232

Daniela Kovacs, Emilia Migliano, Luca Muscardin, Vitaliano Silipo, Caterina Catricalà, Mauro Picardo,  and Barbara Bellei
43295-43314
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The impact of intermittent versus continuous exposure to EGFR tyrosine kinase inhibitor on selection of EGFR T790M-mutant drug-resistant clones in a lung cancer cell line carrying activating EGFR mutation

The impact of intermittent versus continuous exposure to EGFR tyrosine kinase inhibitor on selection of EGFR T790M-mutant drug-resistant clones in a lung cancer cell line carrying activating EGFR mutation

https://doi.org/10.18632/oncotarget.9703

Youngjoo Lee, Yu-Ra Choi, Kyoung-Yeon Kim,  and Dong Hoon Shin
43315-43323
Abstract  |  PDF  |  HTML  |  Order a Reprint

14,15-EET induces the infiltration and tumor-promoting function of neutrophils to trigger the growth of minimal dormant metastases

14,15-EET induces the infiltration and tumor-promoting function of neutrophils to trigger the growth of minimal dormant metastases

https://doi.org/10.18632/oncotarget.9709

Jing Luo, Xin-Xia Feng, Chao Luo, Yu Wang, Dong Li, Yu Shu, Shan-Shan Wang, Jian Qin, Yong-Chao Li, Jiu-Ming Zou, De-An Tian, Gui-Mei Zhang,  and Zuo-Hua Feng
43324-43336
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

NEAT1 upregulates EGCG-induced CTR1 to enhance cisplatin sensitivity in lung cancer cells

NEAT1 upregulates EGCG-induced CTR1 to enhance cisplatin sensitivity in lung cancer cells

https://doi.org/10.18632/oncotarget.9712

Pan Jiang, Xiaoyue Wu, Xuemin Wang, Wenbin Huang,  and Qing Feng
43337-43351
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Anti-tax interacting protein-1 (TIP-1) monoclonal antibody targets human cancers

Anti-tax interacting protein-1 (TIP-1) monoclonal antibody targets human cancers

https://doi.org/10.18632/oncotarget.9713

Heping Yan, Vaishali Kapoor, Kim Nguyen, Walter J. Akers, Hua Li, Jalen Scott, Richard Laforest, Buck Rogers, Dinesh Thotala,  and Dennis Hallahan
43352-43362
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

E-cadherin re-expression shows in vivo evidence for mesenchymal to epithelial transition in clonal metastatic breast tumor cells

E-cadherin re-expression shows in vivo evidence for mesenchymal to epithelial transition in clonal metastatic breast tumor cells

https://doi.org/10.18632/oncotarget.9715

Katie Palen, James Weber, Michael B. Dwinell, Bryon D. Johnson, Ramani Ramchandran,  and Jill A. Gershan
43363-43375
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PIK3C2A mRNA functions as a miR-124 sponge to facilitate CD151 expression and enhance malignancy of hepatocellular carcinoma cells

PIK3C2A mRNA functions as a miR-124 sponge to facilitate CD151 expression and enhance malignancy of hepatocellular carcinoma cells

https://doi.org/10.18632/oncotarget.9716

Tao Liu, Cai-Hua Zu, Shu-Sen Wang, Hong-Li Song, Zheng-Lu Wang, Xin-Nv Xu, Hong-Sheng Liu, Yu-Liang Wang,  and Zhong-Yang Shen
43376-43389
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Sirt3-mediated mitophagy protects tumor cells against apoptosis under hypoxia

Sirt3-mediated mitophagy protects tumor cells against apoptosis under hypoxia

https://doi.org/10.18632/oncotarget.9717

Aimin Qiao, Kuansong Wang, Yunsheng Yuan, Yidi Guan, Xingcong Ren, Lanya Li, Xisha Chen, Feng Li, Alex F. Chen, Jianda Zhou, Jin-Ming Yang,  and Yan Cheng
43390-43400
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Eukaryotic translation initiation factor 3B accelerates the progression of esophageal squamous cell carcinoma by activating β-catenin signaling pathway

Eukaryotic translation initiation factor 3B accelerates the progression of esophageal squamous cell carcinoma by activating β-catenin signaling pathway

https://doi.org/10.18632/oncotarget.9726

Fengkai Xu, Cheng-Zhi Xu, Jie Gu, Xiaoming Liu, Ronghua Liu, Enyu Huang, Yunfeng Yuan, Guangyin Zhao, Jiahao Jiang, Chen Xu, Yiwei Chu, Chunlai Lu,  and Di Ge
43401-43411
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Cell-free DNA mutations as biomarkers in breast cancer patients receiving tamoxifen

Cell-free DNA mutations as biomarkers in breast cancer patients receiving tamoxifen

https://doi.org/10.18632/oncotarget.9727

Maurice P.H.M. Jansen, John W.M. Martens, Jean C.A. Helmijr, Corine M. Beaufort, Ronald van Marion, Niels M.G. Krol, Kim Monkhorst, Anita M.A.C. Trapman- Jansen, Marion E. Meijer-van Gelder, Marjolein J.A. Weerts, Diana E. Ramirez- Ardila, Hendrikus Jan Dubbink, John A. Foekens, Stefan Sleijfer,  and Els M.J.J. Berns
43412-43418
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Loss of miR-1258 contributes to carcinogenesis and progression of liver cancer through targeting CDC28 protein kinase regulatory subunit 1B

Loss of miR-1258 contributes to carcinogenesis and progression of liver cancer through targeting CDC28 protein kinase regulatory subunit 1B

https://doi.org/10.18632/oncotarget.9728

Minghua Hu, Mingwei Wang, Huihong Lu, Xiaoming Wang, Xiaoshan Fang, Jinguo Wang, Chenyang Ma, Xiaobing Chen,  and Hongping Xia
43419-43431
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Urine gamma-synuclein as a biomarker for the diagnosis of bladder cancer

Urine gamma-synuclein as a biomarker for the diagnosis of bladder cancer

https://doi.org/10.18632/oncotarget.9468

Caiyun Liu, Bingbing Shi, Chonghua Hao, Qinghai Wang, Qiang Lv, Nianzeng Xing, Jianzhong Shou, Like Qu, Yanning Gao, Chao Qin, Jiyu Zhao,  and Chengchao Shou
43432-43441
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Chemotherapy-related cachexia is associated with mitochondrial depletion and the activation of ERK1/2 and p38 MAPKs

Chemotherapy-related cachexia is associated with mitochondrial depletion and the activation of ERK1/2 and p38 MAPKs

https://doi.org/10.18632/oncotarget.9779

Rafael Barreto, David L. Waning, Hongyu Gao, Yunlong Liu, Teresa A. Zimmers,  and Andrea Bonetto
43442-43460
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Mediation of the malignant biological characteristics of gastric cancer cells by the methylated CpG islands in RNF180 DNA promoter

Mediation of the malignant biological characteristics of gastric cancer cells by the methylated CpG islands in RNF180 DNA promoter

https://doi.org/10.18632/oncotarget.9494

Jingyu Deng, Jiangtao Guo, Xiaofan Guo, Yachao Hou, Xingming Xie, Changyu Sun, Rupeng Zhang, Xiaohua Yu,  and Han Liang
43461-43474
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(-)-Oleocanthal inhibits growth and metastasis by blocking activation of STAT3 in human hepatocellular carcinoma

(-)-Oleocanthal inhibits growth and metastasis by blocking activation of STAT3 in human hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.9782

Tiemin Pei, Qinghui Meng, Jihua Han, Haobo Sun, Long Li, Ruipeng Song, Boshi Sun, Shangha Pan, Desen Liang,  and Lianxin Liu
43475-43491
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MCT4 as a potential therapeutic target for metastatic gastric cancer with peritoneal carcinomatosis

MCT4 as a potential therapeutic target for metastatic gastric cancer with peritoneal carcinomatosis

https://doi.org/10.18632/oncotarget.9523

Ji Yun Lee, InKyoung Lee, Won Jin Chang, Su Min Ahn, Sung Hee Lim, Hae Su Kim, Kwai Han Yoo, Ki Sun Jung, Haa-Na Song, Jin Hyun Cho, Sun Young Kim, Kyoung-Mee Kim, Soojin Lee, Seung Tae Kim, Se Hoon Park, Jeeyun Lee, Joon Oh Park, Young Suk Park, Ho Yeong Lim,  and Won Ki Kang
43492-43503
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

BET bromodomain inhibitors suppress EWS-FLI1-dependent transcription and the IGF1 autocrine mechanism in Ewing sarcoma

BET bromodomain inhibitors suppress EWS-FLI1-dependent transcription and the IGF1 autocrine mechanism in Ewing sarcoma

https://doi.org/10.18632/oncotarget.9762

Sudan N. Loganathan, Nan Tang, Jonathan T. Fleming, Yufang Ma, Yan Guo, Scott C. Borinstein, Chin Chiang,  and Jialiang Wang
43504-43517
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

HIF2α/EFEMP1 cascade mediates hypoxic effects on breast cancer stem cell hierarchy

HIF2α/EFEMP1 cascade mediates hypoxic effects on breast cancer stem cell hierarchy

https://doi.org/10.18632/oncotarget.9846

Ji-Hye Kwak, Na-Hee Lee, Hwa-Yong Lee, In-Sun Hong,  and Jeong-Seok Nam
43518-43533
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The transcription factor FOXN3 inhibits cell proliferation by downregulating E2F5 expression in hepatocellular carcinoma cells

The transcription factor FOXN3 inhibits cell proliferation by downregulating E2F5 expression in hepatocellular carcinoma cells

https://doi.org/10.18632/oncotarget.9780

Ji Sun, Hong Li, Qi Huo, Meiling Cui, Chao Ge, Fangyu Zhao, Hua Tian, Taoyang Chen, Ming Yao,  and Jinjun Li
43534-43545
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Evaluation and characterization of anti-RalA autoantibody as a potential serum biomarker in human prostate cancer

Evaluation and characterization of anti-RalA autoantibody as a potential serum biomarker in human prostate cancer

https://doi.org/10.18632/oncotarget.9869

Jitian Li, Liping Dai, Ningjing Lei, Mengtao Xing, Pei Li, Chenglin Luo, Carlos A. Casiano,  and Jian-Ying Zhang
43546-43556
Abstract  |  PDF  |  HTML  |  Order a Reprint

Targeted next-generation sequencing of dedifferentiated chondrosarcoma in the skull base reveals combined TP53 and PTEN mutations with increased proliferation index, an implication for pathogenesis

Targeted next-generation sequencing of dedifferentiated chondrosarcoma in the skull base reveals combined TP53 and PTEN mutations with increased proliferation index, an implication for pathogenesis

https://doi.org/10.18632/oncotarget.9618

Lu Gao, Xiafei Hong, Xiaopeng Guo, Dengfeng Cao, Xiaohuan Gao, Thomas F. DeLaney, Xinqi Gong, Rongrong Chen, Jianjiao Ni, Yong Yao, Renzhi Wang, Xi Chen, Pangzehuan Tian,  and Bing Xing
43557-43569
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Extracellular vesicles secreted by highly metastatic clonal variants of osteosarcoma preferentially localize to the lungs and induce metastatic behaviour in poorly metastatic clones

Extracellular vesicles secreted by highly metastatic clonal variants of osteosarcoma preferentially localize to the lungs and induce metastatic behaviour in poorly metastatic clones

https://doi.org/10.18632/oncotarget.9781

Rebecca Macklin, Haolu Wang, Dorothy Loo, Sally Martin, Andrew Cumming, Na Cai, Rebecca Lane, Natalia Saenz Ponce, Eleni Topkas, Kerry Inder, Nicholas A Saunders,  and Liliana Endo-Munoz
43570-43587
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Long noncoding RNA CPS1-IT1 suppresses the metastasis of hepatocellular carcinoma by regulating HIF-1α activity and inhibiting epithelial-mesenchymal transition

Long noncoding RNA CPS1-IT1 suppresses the metastasis of hepatocellular carcinoma by regulating HIF-1α activity and inhibiting epithelial-mesenchymal transition

https://doi.org/10.18632/oncotarget.9635

Tong-Hong Wang, Cheng-Chia Yu, Yong-Shiang Lin, Tse-Ching Chen, Chau-Ting Yeh, Kung-Hao Liang, Tzong-Ming Shieh, Chi-Yuan Chen,  and Chuen Hsueh
43588-43603
Abstract  |  PDF  |  HTML  |  Order a Reprint

Profiling the dynamic expression of checkpoint molecules on cytokine-induced killer cells from non-small-cell lung cancer patients

Profiling the dynamic expression of checkpoint molecules on cytokine-induced killer cells from non-small-cell lung cancer patients

https://doi.org/10.18632/oncotarget.9871

Lin Zhang, Jian Wang, Feng Wei, Kaiyuan Wang, Qian Sun, Fan Yang, Hao Jin, Yu Zheng, Hua Zhao, Limei Wang, Wenwen Yu, Xiying Zhang, Yang An, Lili Yang, Xinwei Zhang,  and Xiubao Ren
43604-43615
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Multi-targeting NGR-modified liposomes recognizing glioma tumor cells and vasculogenic mimicry for improving anti-glioma therapy

Multi-targeting NGR-modified liposomes recognizing glioma tumor cells and vasculogenic mimicry for improving anti-glioma therapy

https://doi.org/10.18632/oncotarget.9889

Dan Huang, Shuang Zhang, Ting Zhong, Wei Ren, Xin Yao, Yang Guo, Xiao-Chuan Duan, Yi-Fan Yin, Shu-Shi Zhang,  and Xuan Zhang
43616-43628
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Overexpression of transient receptor potential mucolipin-2 ion channels in gliomas: role in tumor growth and progression

Overexpression of transient receptor potential mucolipin-2 ion channels in gliomas: role in tumor growth and progression

https://doi.org/10.18632/oncotarget.9661

Maria Beatrice Morelli, Massimo Nabissi, Consuelo Amantini, Daniele Tomassoni, Francesco Rossi, Claudio Cardinali, Matteo Santoni, Antonietta Arcella, Maria Antonietta Oliva, Angela Santoni, Carlo Polidori, Maria Paola Mariani,  and Giorgio Santoni
43654-43668
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The association between BMI and gallbladder cancer risk: a meta-analysis

The association between BMI and gallbladder cancer risk: a meta-analysis

https://doi.org/10.18632/oncotarget.9664

Zhan-Ming Li, Zhao-Xia Wu, Bing Han, Yu-Qin Mao, Hui-Ling Chen, San-Feng Han, Jing-Lin Xia,  and Li-Shun Wang
43669-43679
Abstract  |  PDF  |  HTML  |  Order a Reprint

The prognostic value of lymph nodes count on survival of patients with node-negative gastric cancer

The prognostic value of lymph nodes count on survival of patients with node-negative gastric cancer

https://doi.org/10.18632/oncotarget.9845

Wei-feng Zheng, Ting-ting Ji, Yong Lin,  and Rong-zhou Li
43680-43688
Abstract  |  PDF  |  HTML  |  Order a Reprint

Blocking the PAH2 domain of Sin3A inhibits tumorigenesis and confers retinoid sensitivity in triple negative breast cancer

Blocking the PAH2 domain of Sin3A inhibits tumorigenesis and confers retinoid sensitivity in triple negative breast cancer

https://doi.org/10.18632/oncotarget.9905

Nidhi Bansal, Almudena Bosch, Boris Leibovitch, Lutecia Pereira, Elena Cubedo, Jianshi Yu, Keely Pierzchalski, Jace W. Jones, Melissa Fishel, Maureen Kane, Arthur Zelent, Samuel Waxman,  and Eduardo Farias
43689-43702
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Polymorphisms in TIM-3 and breast cancer susceptibility in Chinese women: A case-control study

Polymorphisms in TIM-3 and breast cancer susceptibility in Chinese women: A case-control study

https://doi.org/10.18632/oncotarget.9665

Zheng Wang, Xinghan Liu, Xijing Wang, Tie Chong, Shuai Lin, Meng Wang, Xiaobin Ma, Kang Liu, Peng Xu, Yanjing Feng,  and Zhijun Dai
43703-43712
Abstract  |  PDF  |  HTML  |  Order a Reprint

Targeting ACLY sensitizes castration-resistant prostate cancer cells to AR antagonism by impinging on an ACLY-AMPK-AR feedback mechanism

Targeting ACLY sensitizes castration-resistant prostate cancer cells to AR antagonism by impinging on an ACLY-AMPK-AR feedback mechanism

https://doi.org/10.18632/oncotarget.9666

Supriya Shah, Whitney J. Carriveau, Jinyang Li, Sydney L. Campbell, Piotr K. Kopinski, Hee-Woong Lim, Natalie Daurio, Sophie Trefely, Kyoung-Jae Won, Douglas C. Wallace, Constantinos Koumenis, Anthony Mancuso,  and Kathryn E. Wellen
43713-43730
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Redox-sensitive MAPK and Notch3 regulate fibroblast differentiation and activation: a dual role of ERK1/2

Redox-sensitive MAPK and Notch3 regulate fibroblast differentiation and activation: a dual role of ERK1/2

https://doi.org/10.18632/oncotarget.9667

Jun-Mei Lai, Xiong Zhang, Fang-Fang Liu, Rui Yang, Shen-Yu Li, Lan-Bing Zhu, Ming Zou, Wen-Hsing Cheng,  and Jian-Hong Zhu
43731-43745
Abstract  |  PDF  |  HTML  |  Order a Reprint

Dual targeting of PI3K and MEK enhances the radiation response of K-RAS mutated non-small cell lung cancer

Dual targeting of PI3K and MEK enhances the radiation response of K-RAS mutated non-small cell lung cancer

https://doi.org/10.18632/oncotarget.9670

Mahmoud Toulany, Mari Iida, Simone Keinath, Firdevs F. Iyi, Katharina Mueck, Birgit Fehrenbacher, Wael Y. Mansour, Martin Schaller, Deric L. Wheeler,  and H. Peter Rodemann
43746-43761
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Combination of gemcitabine-containing magnetoliposome and oxaliplatin-containing magnetoliposome in breast cancer treatment: A possible mechanism with potential for clinical application

Combination of gemcitabine-containing magnetoliposome and oxaliplatin-containing magnetoliposome in breast cancer treatment: A possible mechanism with potential for clinical application

https://doi.org/10.18632/oncotarget.9671

Hui Ye, Jiansong Tong, Jiangyi Liu, Wenman Lin, Chengshou Zhang, Kai Chen, Jie Zhao,  and Wenjing Zhu
43762-43778
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

AKR1B10 promotes breast cancer metastasis through integrin α5/δ-catenin mediated FAK/Src/Rac1 signaling pathway

AKR1B10 promotes breast cancer metastasis through integrin α5/δ-catenin mediated FAK/Src/Rac1 signaling pathway

https://doi.org/10.18632/oncotarget.9672

Chenfei Huang, Steven Verhulst, Yi Shen, Yiwen Bu, Yu Cao, Yingchun He, Yuhong Wang, Dan Huang, Chun Cai, Krishna Rao, Duan-Fang Liao, Junfei Jin,  and Deliang Cao
43779-43791
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

IRE1α inhibition by natural compound genipin on tumour associated macrophages reduces growth of hepatocellular carcinoma

IRE1α inhibition by natural compound genipin on tumour associated macrophages reduces growth of hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.9696

Hor-Yue Tan, Ning Wang, Sai-Wah Tsao, Chi-Ming Che, Man-Fung Yuen,  and Yibin Feng
43792-43804
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Aberrant methylation-mediated silencing of microRNAs contributes to HPV-induced anchorage independence

Aberrant methylation-mediated silencing of microRNAs contributes to HPV-induced anchorage independence

https://doi.org/10.18632/oncotarget.9698

Saskia M. Wilting, Viktorian Miok, Annelieke Jaspers, Debby Boon, Hanne Sørgård, Malin Lando, Barbara C. Snoek, Wessel N. van Wieringen, Chris J.L.M. Meijer, Heidi Lyng, Peter J.F. Snijders,  and Renske D.M. Steenbergen
43805-43819
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

ER stress in temozolomide-treated glioblastomas interferes with DNA repair and induces apoptosis

ER stress in temozolomide-treated glioblastomas interferes with DNA repair and induces apoptosis

https://doi.org/10.18632/oncotarget.9907

Jessica L. Weatherbee, Jean-Louis Kraus,  and Alonzo H. Ross
43820-43834
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Long noncoding RNA RP11-838N2.4 enhances the cytotoxic effects of temozolomide by inhibiting the functions of miR-10a in glioblastoma cell lines

Long noncoding RNA RP11-838N2.4 enhances the cytotoxic effects of temozolomide by inhibiting the functions of miR-10a in glioblastoma cell lines

https://doi.org/10.18632/oncotarget.9699

Yanting Liu, Ningbo Xu, Boyang Liu, Yiru Huang, Huijun Zeng, Zhao Yang, Zhenyan He,  and Hongbo Guo
43835-43851
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Direct contact with perivascular tumor cells enhances integrin αvβ3 signaling and migration of endothelial cells

Direct contact with perivascular tumor cells enhances integrin αvβ3 signaling and migration of endothelial cells

https://doi.org/10.18632/oncotarget.9700

Monica E. Burgett, Justin D. Lathia, Patrick Roth, Amy S. Nowacki, Deni S. Galileo, Elena Pugacheva, Ping Huang, Amit Vasanji, Meizhang Li, Tatiana Byzova, Tom Mikkelsen, Shideng Bao, Jeremy N. Rich, Michael Weller,  and Candece L. Gladson
43852-43867
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Quantitative proteomics reveals that distant recurrence-associated protein R-Ras and Transgelin predict post-surgical survival in patients with Stage III colorectal cancer

Quantitative proteomics reveals that distant recurrence-associated protein R-Ras and Transgelin predict post-surgical survival in patients with Stage III colorectal cancer

https://doi.org/10.18632/oncotarget.9701

Lai Xu, Yanpan Gao, Yanyu Chen, Yi Xiao, Qingzhong He, Huizhong Qiu,  and Wei Ge
43868-43893
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Whole-exome sequencing to identify somatic mutations in peritoneal metastatic gastric adenocarcinoma: A preliminary study

Whole-exome sequencing to identify somatic mutations in peritoneal metastatic gastric adenocarcinoma: A preliminary study

https://doi.org/10.18632/oncotarget.9707

Hao Liu, Fengping Li, Yu Zhu, Tingting Li, Haipeng Huang, Tian Lin, Yanfeng Hu, Xiaolong Qi, Jiang Yu,  and Guoxin Li
43894-43906
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Ellagitannin-rich cloudberry inhibits hepatocyte growth factor induced cell migration and phosphatidylinositol 3-kinase/AKT activation in colon carcinoma cells and tumors in Min mice

Ellagitannin-rich cloudberry inhibits hepatocyte growth factor induced cell migration and phosphatidylinositol 3-kinase/AKT activation in colon carcinoma cells and tumors in Min mice

https://doi.org/10.18632/oncotarget.9724

Anne-Maria Pajari, Essi Päivärinta, Lassi Paavolainen, Elina Vaara, Tuuli Koivumäki, Ritu Garg, Anu Heiman-Lindh, Marja Mutanen, Varpu Marjomäki,  and Anne J. Ridley
43907-43923
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

KCNN4 and S100A14 act as predictors of recurrence in optimally debulked patients with serous ovarian cancer

KCNN4 and S100A14 act as predictors of recurrence in optimally debulked patients with serous ovarian cancer

https://doi.org/10.18632/oncotarget.9721

Haiyue Zhao, Ensong Guo, Ting Hu, Qian Sun, Jianli Wu, Xingguang Lin, Danfeng Luo, Chaoyang Sun, Changyu Wang, Bo Zhou, Na Li, Meng Xia, Hao Lu, Li Meng, Xiaoyan Xu, Junbo Hu, Ding Ma, Gang Chen,  and Tao Zhu
43924-43938
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Quantitative in vivo optical tomography of cancer progression & vasculature development in adult zebrafish

Quantitative in vivo optical tomography of cancer progression & vasculature development in adult zebrafish

https://doi.org/10.18632/oncotarget.9756

Sunil Kumar, Nicola Lockwood, Marie-Christine Ramel, Teresa Correia, Matthew Ellis, Yuriy Alexandrov, Natalie Andrews, Rachel Patel, Laurence Bugeon, Margaret J. Dallman, Sebastian Brandner, Simon Arridge, Matilda Katan, James McGinty, Paul Frankel,  and Paul M.W. French
43939-43948
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Human pluripotent stem cell (PSC)-derived mesenchymal stem cells (MSCs) show potent neurogenic capacity which is enhanced with cytoskeletal rearrangement

Human pluripotent stem cell (PSC)-derived mesenchymal stem cells (MSCs) show potent neurogenic capacity which is enhanced with cytoskeletal rearrangement

https://doi.org/10.18632/oncotarget.9947

Kai-Yen Peng, Yu-Wei Lee, Pei-Ju Hsu, Hsiu-Huan Wang, Yun Wang, Jun-Yang Liou, Shan-Hui Hsu, Kenneth K. Wu,  and B. Linju Yen
43949-43959
Abstract  |  PDF  |  HTML  |  Order a Reprint

MLLT11/AF1q boosts oncogenic STAT3 activity through Src-PDGFR tyrosine kinase signaling

MLLT11/AF1q boosts oncogenic STAT3 activity through Src-PDGFR tyrosine kinase signaling

https://doi.org/10.18632/oncotarget.9759

Jino Park, Soojin Kim, Joongho Joh, Scot C. Remick, Donald M. Miller, Jun Yan, Zeyad Kanaan, Ju-Hsien Chao, Maxwell M. Krem, Soumit K. Basu, Shotaro Hagiwara, Lukas Kenner, Richard Moriggl, Kevin D. Bunting,  and William Tse
43960-43973
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Crucial factors of the inflammatory microenvironment (IL-1β/ TNF-α/TIMP-1) promote the maintenance of the malignant hemopoietic clone of myelofibrosis: an in vitro study

Crucial factors of the inflammatory microenvironment (IL-1β/ TNF-α/TIMP-1) promote the maintenance of the malignant hemopoietic clone of myelofibrosis: an in vitro study

https://doi.org/10.18632/oncotarget.9949

Daria Sollazzo, Dorian Forte, Nicola Polverelli, Marco Romano, Margherita Perricone, Lara Rossi, Emanuela Ottaviani, Simona Luatti, Giovanni Martinelli, Nicola Vianelli, Michele Cavo, Francesca Palandri,  and Lucia Catani
43974-43988
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Demonstration of potential link between Helicobacter pylori related promoter CpG island methylation and telomere shortening in human gastric mucosa

Demonstration of potential link between Helicobacter pylori related promoter CpG island methylation and telomere shortening in human gastric mucosa

https://doi.org/10.18632/oncotarget.9764

Tomomitsu Tahara, Tomoyuki Shibata, Masaaki Okubo, Tomohiko Kawamura, Noriyuki Horiguchi, Takamitsu Ishizuka, Naoko Nakano, Mitsuo Nagasaka, Yoshihito Nakagawa,  and Naoki Ohmiya
43989-43996
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

BET inhibition as a new strategy for the treatment of gastric cancer

BET inhibition as a new strategy for the treatment of gastric cancer

https://doi.org/10.18632/oncotarget.9766

Raquel C. Montenegro, Peter G.K. Clark, Alison Howarth, Xiao Wan, Alessandro Ceroni, Paulina Siejka, Graciela A. Nunez-Alonso, Octovia Monteiro, Catherine Rogers, Vicki Gamble, Rommel Burbano, Paul E. Brennan, Cynthia Tallant, Daniel Ebner, Oleg Fedorov, Eric O'Neill, Stefan Knapp, Darren Dixon,  and Susanne Müller
43997-44012
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MDM2 knockdown mediated by a triazine-modified dendrimer in the treatment of non-small cell lung cancer

MDM2 knockdown mediated by a triazine-modified dendrimer in the treatment of non-small cell lung cancer

https://doi.org/10.18632/oncotarget.9768

Quan Huang, Lei Li, Lin Li, Hui Chen, Yongyan Dang, Jishen Zhang, Naimin Shao, Hong Chang, Zhengjie Zhou, Chongyi Liu, Bingwei He, Haifeng Wei,  and Jianru Xiao
44013-44022
Abstract  |  PDF  |  HTML  |  Order a Reprint

MiR-422a promotes loco-regional recurrence by targeting NT5E/CD73 in head and neck squamous cell carcinoma

MiR-422a promotes loco-regional recurrence by targeting NT5E/CD73 in head and neck squamous cell carcinoma

https://doi.org/10.18632/oncotarget.9829

Nathalie Bonnin, Emma Armandy, Julien Carras, Sylvain Ferrandon, Priscillia Battiston-Montagne, Marc Aubry, Sébastien Guihard, David Meyronet, Jean-Philippe Foy, Pierre Saintigny, Sonia Ledrappier, Alain Jung, Ruth Rimokh, Claire Rodriguez-Lafrasse,  and Delphine Poncet
44023-44038
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Meta-analysis of the efficacy of the pretreatment neutrophil-to-lymphocyte ratio as a predictor of prognosis in renal carcinoma patients receiving tyrosine kinase inhibitors

Meta-analysis of the efficacy of the pretreatment neutrophil-to-lymphocyte ratio as a predictor of prognosis in renal carcinoma patients receiving tyrosine kinase inhibitors

https://doi.org/10.18632/oncotarget.9836

Ning Na, Jia Yao, Cailian Cheng, Zhengyu Huang, Liangqing Hong, Heng Li,  and Jiang Qiu
44039-44046
Abstract  |  PDF  |  HTML  |  Order a Reprint

Increased expression of SKP2 is an independent predictor of locoregional recurrence in cervical cancer via promoting DNA-damage response after irradiation

Increased expression of SKP2 is an independent predictor of locoregional recurrence in cervical cancer via promoting DNA-damage response after irradiation

https://doi.org/10.18632/oncotarget.10057

Hung-Chun Fu, Yi-Chien Yang, Yun-Ju Chen, Hao Lin, Yu-Che Ou, Chan-Chao Chang Chien, Eng-Yen Huang, Hsuan-Ying Huang, Jui Lan, Hsi-Ping Chi, Ko-En Huang,  and Hong-Yo Kang
44047-44061
Abstract  |  PDF  |  HTML  |  Order a Reprint

Cyr61 and YB-1 are novel interacting partners of uPAR and elevate the malignancy of triple-negative breast cancer

Cyr61 and YB-1 are novel interacting partners of uPAR and elevate the malignancy of triple-negative breast cancer

https://doi.org/10.18632/oncotarget.9853

Michaela C. Huber, Natalie Falkenberg, Stefanie M. Hauck, Markus Priller, Herbert Braselmann, Annette Feuchtinger, Axel Walch, Manfred Schmitt,  and Michaela Aubele
44062-44075
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Hepatitis B virus genotypes, expression quantitative trait loci for ZNRD1-AS1 and their interactions in hepatocellular carcinoma

Hepatitis B virus genotypes, expression quantitative trait loci for ZNRD1-AS1 and their interactions in hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.9854

Zhenzhen Liu, Ci Song, Juan Wen, Lu Xu, Yao Liu, Jian Zhu, Liguo Zhu, Zhibin Hu, Hongxia Ma,  and Li Liu
44076-44083
Abstract  |  PDF  |  HTML  |  Order a Reprint

Reduced genomic tumor heterogeneity after neoadjuvant chemotherapy is related to favorable outcome in patients with esophageal adenocarcinoma

Reduced genomic tumor heterogeneity after neoadjuvant chemotherapy is related to favorable outcome in patients with esophageal adenocarcinoma

https://doi.org/10.18632/oncotarget.9857

Askar Obulkasim, Bauke Ylstra, Hendrik F. van Essen, Christian Benner, Sally Stenning, Ruth Langley, William Allum, David Cunningham, Imran Inam, Lindsay C. Hewitt, Nicolas P. West, Gerrit A. Meijer, Mark A. van de Wiel,  and Heike I. Grabsch
44084-44095
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Breast cancer subtype dictates DNA methylation and ALDH1A3-mediated expression of tumor suppressor RARRES1

Breast cancer subtype dictates DNA methylation and ALDH1A3-mediated expression of tumor suppressor RARRES1

https://doi.org/10.18632/oncotarget.9858

Krysta M. Coyle, J. Patrick Murphy, Dejan Vidovic, Ahmad Vaghar-Kashani, Cheryl A. Dean, Mohammad Sultan, Derek Clements, Melissa Wallace, Margaret L. Thomas, Amos Hundert, Carman A. Giacomantonio, Lucy Helyer, Shashi A. Gujar, Patrick W.K. Lee, Ian C.G. Weaver,  and Paola Marcato
44096-44112
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

UCN-01 enhances cytotoxicity of irinotecan in colorectal cancer stem-like cells by impairing DNA damage response

UCN-01 enhances cytotoxicity of irinotecan in colorectal cancer stem-like cells by impairing DNA damage response

https://doi.org/10.18632/oncotarget.9859

Michele Signore, Mariachiara Buccarelli, Emanuela Pilozzi, Gabriele De Luca, Marianna Cappellari, Maurizio Fanciulli, Frauke Goeman, Elisa Melucci, Mauro Biffoni,  and Lucia Ricci-Vitiani
44113-44128
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Silencing DNA methyltransferase 1 (DNMT1) inhibits proliferation, metastasis and invasion in ESCC by suppressing methylation of RASSF1A and DAPK

Silencing DNA methyltransferase 1 (DNMT1) inhibits proliferation, metastasis and invasion in ESCC by suppressing methylation of RASSF1A and DAPK

https://doi.org/10.18632/oncotarget.9866

Jian Bai, Xue Zhang, Kai Hu, Bangqing Liu, Haiyong Wang, Angui Li, Feng Lin, Lifei Zhang, Xiaolin Sun, Zhenzong Du,  and Jianfei Song
44129-44141
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Mitochondrial clearance by the STK38 kinase supports oncogenic Ras-induced cell transformation

Mitochondrial clearance by the STK38 kinase supports oncogenic Ras-induced cell transformation

https://doi.org/10.18632/oncotarget.9875

Audrey Bettoun, Carine Joffre, Giulia Zago, Didier Surdez, David Vallerand, Ramazan Gundogdu, Ahmad A.D. Sharif, Marta Gomez, Ilaria Cascone, Brigitte Meunier, Michael A. White, Patrice Codogno, Maria Carla Parrini, Jacques H. Camonis,  and Alexander Hergovich
44142-44160
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Aquaporin 9 inhibits hepatocellular carcinoma through up-regulating FOXO1 expression

Aquaporin 9 inhibits hepatocellular carcinoma through up-regulating FOXO1 expression

https://doi.org/10.18632/oncotarget.10143

Chuan-Fei Li, Wen-Guang Zhang, Min Liu, Lie-Wang Qiu, Xiao-Feng Chen, Lin Lv,  and Zhe-Chuan Mei
44161-44170
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Inhibition of histone deacetylases induces formation of multipolar spindles and subsequent p53-dependent apoptosis in nasopharyngeal carcinoma cells

Inhibition of histone deacetylases induces formation of multipolar spindles and subsequent p53-dependent apoptosis in nasopharyngeal carcinoma cells

https://doi.org/10.18632/oncotarget.9922

Min Yan, Yuan-min Qian, Cai-feng Yue, Zi-feng Wang, Bi-cheng Wang, Wei Zhang, Fei-meng Zheng,  and Quentin Liu
44171-44184
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Systemic immune-inflammation index, thymidine phosphorylase and survival of localized gastric cancer patients after curative resection

Systemic immune-inflammation index, thymidine phosphorylase and survival of localized gastric cancer patients after curative resection

https://doi.org/10.18632/oncotarget.9923

Liu Huang, Shan Liu, Yu Lei, Kun Wang, Min Xu, Yaobing Chen, Bo Liu, Yangyang Chen, Qiang Fu, Peng Zhang, Kai Qin, Yixin Cai, Shengling Fu, Shuwang Ge,  and Xianglin Yuan
44185-44193
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Missense mutations in the TP53 DNA-binding domain predict outcomes in patients with advanced oral cavity squamous cell carcinoma

Missense mutations in the TP53 DNA-binding domain predict outcomes in patients with advanced oral cavity squamous cell carcinoma

https://doi.org/10.18632/oncotarget.9925

Nina Lapke, Yen-Jung Lu, Chun-Ta Liao, Li-Yu Lee, Chien-Yu Lin, Hung-Ming Wang, Shu-Hang Ng, Shu-Jen Chen,  and Tzu-Chen Yen
44194-44210
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Multiple-level validation identifies PARK2 in the development of lung cancer and chronic obstructive pulmonary disease

Multiple-level validation identifies PARK2 in the development of lung cancer and chronic obstructive pulmonary disease

https://doi.org/10.18632/oncotarget.9954

SeungBaek Lee, Jun She, Bo Deng, JungJin Kim, Mariza de Andrade, Jie Na, Zhifu Sun, Jason A. Wampfler, Julie M. Cunningham, Yanhong Wu, Andrew H. Limper, Marie-Christine Aubry, Chris Wendt, Peter Biterman, Ping Yang,  and Zhenkun Lou
44211-44223
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Dual-timing PSA as a biomarker for patients with salvage intensity modulated radiation therapy for biochemical failure after radical prostatectomy

Dual-timing PSA as a biomarker for patients with salvage intensity modulated radiation therapy for biochemical failure after radical prostatectomy

https://doi.org/10.18632/oncotarget.10000

Yu-Jen Wang, Chao-Yuan Huang, Wei-Hsien Hou, Chia-Chun Wang, Keng-Hsueh Lan, Hong-Jen Yu, Ming-Kuen Lai, Shihh-Ping Liu, Yeong-Shau Pu,  and Jason Chia-Hsien Cheng
44224-44235
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Telomeric repeat-binding factor 2: a marker for survival and anti-EGFR efficacy in oral carcinoma

Telomeric repeat-binding factor 2: a marker for survival and anti-EGFR efficacy in oral carcinoma

https://doi.org/10.18632/oncotarget.10005

Yordan Benhamou, Vincent Picco, Hélène Raybaud, Anne Sudaka, Emmanuel Chamorey, Sanja Brolih, Martino Monteverde, Marco Merlano, Cristiana Lo Nigro, Damien Ambrosetti,  and Gilles Pagès
44236-44251
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

miR-22 inhibits tumor growth and metastasis by targeting ATP citrate lyase: evidence in osteosarcoma, prostate cancer, cervical cancer and lung cancer

miR-22 inhibits tumor growth and metastasis by targeting ATP citrate lyase: evidence in osteosarcoma, prostate cancer, cervical cancer and lung cancer

https://doi.org/10.18632/oncotarget.10020

Mei Xin, Zhiguang Qiao, Jing Li, Jianjun Liu, Shaoli Song, Xiaoping Zhao, Ping Miao, Tingting Tang, Lei Wang, Weichun Liu, Xiaodi Yang, Kerong Dai,  and Gang Huang
44252-44265
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MicroRNA-187 inhibits tumor growth and invasion by directly targeting CD276 in colorectal cancer

MicroRNA-187 inhibits tumor growth and invasion by directly targeting CD276 in colorectal cancer

https://doi.org/10.18632/oncotarget.10023

Zheng-Shi Wang, Ming Zhong, Yu-Hai Bian, Yi-Fei Mu, Shao-Lan Qin, Min-Hao Yu,  and Jun Qin
44266-44276
Abstract  |  PDF  |  HTML  |  Order a Reprint

p63α modulates c-Myc activity via direct interaction and regulation of MM1 protein stability

p63α modulates c-Myc activity via direct interaction and regulation of MM1 protein stability

https://doi.org/10.18632/oncotarget.10187

Anning Han, Juan Li, Yimin Li, Yang Wang, Johann Bergholz, Yujun Zhang, Chenghua Li,  and Zhi-Xiong Xiao
44277-44287
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Tumor-infiltrating lymphocytes in breast cancer predict the response to chemotherapy and survival outcome: A meta-analysis

Tumor-infiltrating lymphocytes in breast cancer predict the response to chemotherapy and survival outcome: A meta-analysis

https://doi.org/10.18632/oncotarget.9988

Ke Wang, Jianjun Xu, Tao Zhang,  and Dan Xue
44288-44298
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A recombinant chimeric protein specifically induces mutant KRAS degradation and potently inhibits pancreatic tumor growth

A recombinant chimeric protein specifically induces mutant KRAS degradation and potently inhibits pancreatic tumor growth

https://doi.org/10.18632/oncotarget.9996

Ting Pan, Yiwen Zhang, Nan Zhou, Xin He, Cancan Chen, Liting Liang, Xiaobing Duan, Yingtong Lin, Kang Wu,  and Hui Zhang
44299-44309
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

iHyd-PseCp: Identify hydroxyproline and hydroxylysine in proteins by incorporating sequence-coupled effects into general PseAAC

iHyd-PseCp: Identify hydroxyproline and hydroxylysine in proteins by incorporating sequence-coupled effects into general PseAAC

https://doi.org/10.18632/oncotarget.10027

Wang-Ren Qiu, Bi-Qian Sun, Xuan Xiao, Zhao-Chun Xu,  and Kuo-Chen Chou
44310-44321
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Molecular driver alterations and their clinical relevance in cancer of unknown primary site

Molecular driver alterations and their clinical relevance in cancer of unknown primary site

https://doi.org/10.18632/oncotarget.10035

Harald Löffler, Nicole Pfarr, Mark Kriegsmann, Volker Endris, Thomas Hielscher, Philipp Lohneis, Gunnar Folprecht, Albrecht Stenzinger, Manfred Dietel, Wilko Weichert,  and Alwin Krämer
44322-44329
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Study of single nucleotide polymorphisms of FBW7 and its substrate genes revealed a predictive factor for paclitaxel plus cisplatin chemotherapy in Chinese patients with advanced esophageal squamous cell carcinoma

Study of single nucleotide polymorphisms of FBW7 and its substrate genes revealed a predictive factor for paclitaxel plus cisplatin chemotherapy in Chinese patients with advanced esophageal squamous cell carcinoma

https://doi.org/10.18632/oncotarget.9736

Ying Liu, Shu Ning Xu, Yong Shun Chen, Xiao Yuan Wu, Lei Qiao, Ke Li,  and Long Yuan
44330-44339
Abstract  |  PDF  |  HTML  |  Order a Reprint

Involvement of IL-10 and TGF-β in HLA-E-mediated neuroblastoma migration and invasion

Involvement of IL-10 and TGF-β in HLA-E-mediated neuroblastoma migration and invasion

https://doi.org/10.18632/oncotarget.10041

Zijun Zhen, Xiaofang Guo, Ru Liao, Kaibin Yang, Litong Ye,  and Zhiyao You
44340-44349
Abstract  |  PDF  |  HTML  |  Order a Reprint

Linking microsomal prostaglandin E synthase-1/PGE-2 pathway with miR-15a and -186 expression: Novel mechanism of VEGF modulation in prostate cancer

Linking microsomal prostaglandin E synthase-1/PGE-2 pathway with miR-15a and -186 expression: Novel mechanism of VEGF modulation in prostate cancer

https://doi.org/10.18632/oncotarget.10051

Erika Terzuoli, Sandra Donnini, Federica Finetti, Gabriella Nesi, Donata Villari, Hiromi Hanaka, Olof Radmark, Antonio Giachetti,  and Marina Ziche
44350-44364
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

HMGA2 sustains self-renewal and invasiveness of glioma-initiating cells

HMGA2 sustains self-renewal and invasiveness of glioma-initiating cells

https://doi.org/10.18632/oncotarget.9744

Xiaoling Zhong, Xuan Liu, Yamu Li, Man Cheng, Wen Wang, Kuan Tian, Lili Mu, Tao Zeng, Ying Liu, Xiaobing Jiang, Luyang Yu, Liang Gao,  and Yan Zhou
44365-44380
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Novel histopathologic feature identified through image analysis augments stage II colorectal cancer clinical reporting

Novel histopathologic feature identified through image analysis augments stage II colorectal cancer clinical reporting

https://doi.org/10.18632/oncotarget.10053

Peter D. Caie, Ying Zhou, Arran K. Turnbull, Anca Oniscu,  and David J. Harrison
44381-44394
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Evaluation of the prognostic value of tumor-infiltrating lymphocytes in triple-negative breast cancers

Evaluation of the prognostic value of tumor-infiltrating lymphocytes in triple-negative breast cancers

https://doi.org/10.18632/oncotarget.10054

Tian Tian, Miao Ruan, Wentao Yang,  and Ruohong Shui
44395-44405
Abstract  |  PDF  |  HTML  |  Order a Reprint

Identification of Glypican-3 as a potential metastasis suppressor gene in gastric cancer

Identification of Glypican-3 as a potential metastasis suppressor gene in gastric cancer

https://doi.org/10.18632/oncotarget.9763

Shiwei Han, Xuemei Ma, Yanxia Zhao, Hongying Zhao, Ana Batista, Sheng Zhou, Xiaona Zhou, Yao Yang, Tingting Wang, Jingtao Bi, Zheng Xia, Zhigang Bai, Igor Garkavtsev,  and Zhongtao Zhang
44406-44416
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

SPANXA suppresses EMT by inhibiting c-JUN/SNAI2 signaling in lung adenocarcinoma

SPANXA suppresses EMT by inhibiting c-JUN/SNAI2 signaling in lung adenocarcinoma

https://doi.org/10.18632/oncotarget.10088

Yi-Jing Hsiao, Kang-Yi Su, Yi-Chiung Hsu, Gee-Chen Chang, Jin-Shing Chen, Hsuan-Yu Chen, Qi-Sheng Hong, Shih-Chun Hsu, Po-Hsiang Kang, Chia-Ying Hsu, Bing-Ching Ho, Tsung-Hui Yang, Chia-Yu Wang, Yuh-Shan Jou, Pan-Chyr Yang,  and Sung-Liang Yu
44417-44429
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Prevention of pancreatic cancer in a hamster model by cAMP decrease

Prevention of pancreatic cancer in a hamster model by cAMP decrease

https://doi.org/10.18632/oncotarget.9790

Jheelam Banerjee, Arokya M.S. Papu John, Mohammed H. Al-Wadei,  and Hildegard M. Schuller
44430-44441
Abstract  |  PDF  |  HTML  |  Order a Reprint

Long non-coding RNA UCA1 is a predictive biomarker of cancer

Long non-coding RNA UCA1 is a predictive biomarker of cancer

https://doi.org/10.18632/oncotarget.10142

Han-han Hong, Li-kun Hou, Xin Pan, Chun-yan Wu, Hai Huang, Bing Li,  and Wei Nie
44442-44447
Abstract  |  PDF  |  HTML  |  Order a Reprint

Down regulation of Chk1 by p53 plays a role in synergistic induction of apoptosis by chemotherapeutics and inhibitors for Jak2 or BCR/ABL in hematopoietic cells

Down regulation of Chk1 by p53 plays a role in synergistic induction of apoptosis by chemotherapeutics and inhibitors for Jak2 or BCR/ABL in hematopoietic cells

https://doi.org/10.18632/oncotarget.9844

Yoshihiro Umezawa, Tetsuya Kurosu, Hiroki Akiyama, Nang Wu, Ayako Nogami, Toshikage Nagao,  and Osamu Miura
44448-44461
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Prostate tumor-induced angiogenesis is blocked by exosomes derived from menstrual stem cells through the inhibition of reactive oxygen species

Prostate tumor-induced angiogenesis is blocked by exosomes derived from menstrual stem cells through the inhibition of reactive oxygen species

https://doi.org/10.18632/oncotarget.9852

Francisca Alcayaga-Miranda, Paz L. González, Alejandra Lopez-Verrilli, Manuel Varas-Godoy, Carolina Aguila-Díaz, Luis Contreras,  and Maroun Khoury
44462-44477
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Infiltrating macrophages increase RCC epithelial mesenchymal transition (EMT) and stem cell-like populations via AKT and mTOR signaling

Infiltrating macrophages increase RCC epithelial mesenchymal transition (EMT) and stem cell-like populations via AKT and mTOR signaling

https://doi.org/10.18632/oncotarget.9873

Zhao Yang, Hongjun Xie, Dalin He,  and Lei Li
44478-44491
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

High expression of TROP2 characterizes different cell subpopulations in androgen-sensitive and androgen-independent prostate cancer cells

High expression of TROP2 characterizes different cell subpopulations in androgen-sensitive and androgen-independent prostate cancer cells

https://doi.org/10.18632/oncotarget.9876

Jinhan Xie, Christina Mølck, Sophie Paquet-Fifield, Lisa Butler, Australian Prostate Cancer Bioresource, Erica Sloan, Sabatino Ventura,  and Frédéric Hollande
44492-44504
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Synergy between histone deacetylase inhibitors and DNA-damaging agents is mediated by histone deacetylase 2 in colorectal cancer

Synergy between histone deacetylase inhibitors and DNA-damaging agents is mediated by histone deacetylase 2 in colorectal cancer

https://doi.org/10.18632/oncotarget.9887

Samer Alzoubi, Leigh Brody, Sunniyat Rahman, Anne-Laure Mahul-Mellier, Nicolas Mercado, Kazuhiro Ito, Mona El-Bahrawy, Andrew Silver, Alan Boobis, Jimmy D. Bell,  and Nabil Hajji
44505-44521
Abstract  |  PDF  |  HTML  |  Order a Reprint

Onco-miR-130 promotes cell proliferation and migration by targeting TGFβR2 in gastric cancer

Onco-miR-130 promotes cell proliferation and migration by targeting TGFβR2 in gastric cancer

https://doi.org/10.18632/oncotarget.9936

Jingjing Duan, Haiyang Zhang, Yanjun Qu, Ting Deng, Dingzhi Huang, Rui Liu, Le Zhang, Ming Bai, Likun Zhou, Guoguang Ying,  and Yi Ba
44522-44533
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

TGF-β1 contributes to CD8+ Treg induction through p38 MAPK signaling in ovarian cancer microenvironment

TGF-β1 contributes to CD8+ Treg induction through p38 MAPK signaling in ovarian cancer microenvironment

https://doi.org/10.18632/oncotarget.10003

Meng Wu, Xian Chen, Jianfang Lou, Shuping Zhang, Xiaojie Zhang, Lei Huang, Ruihong Sun, Peijun Huang, Fang Wang,  and Shiyang Pan
44534-44544
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Safety and efficacy profile of lenvatinib in cancer therapy: a systematic review and meta-analysis

Safety and efficacy profile of lenvatinib in cancer therapy: a systematic review and meta-analysis

https://doi.org/10.18632/oncotarget.10019

Chenjing Zhu, Xuelei Ma, Yuanyuan Hu, Linghong Guo, Bo Chen, Kai Shen,  and Yue Xiao
44545-44557
Abstract  |  PDF  |  HTML  |  Order a Reprint

The long non-coding RNA HOTAIR increases tumour growth and invasion in cervical cancer by targeting the Notch pathway

The long non-coding RNA HOTAIR increases tumour growth and invasion in cervical cancer by targeting the Notch pathway

https://doi.org/10.18632/oncotarget.10065

Maria Lee, Hee Jung Kim, Sang Wun Kim, Sun-Ae Park, Kyung-Hee Chun, Nam Hoon Cho, Yong Sang Song,  and Young Tae Kim
44558-44571
Abstract  |  PDF  |  HTML  |  Order a Reprint

Activation of PPARγ suppresses proliferation and induces apoptosis of esophageal cancer cells by inhibiting TLR4-dependent MAPK pathway

Activation of PPARγ suppresses proliferation and induces apoptosis of esophageal cancer cells by inhibiting TLR4-dependent MAPK pathway

https://doi.org/10.18632/oncotarget.10067

Kai Wu, Yang Yang, Donglei Liu, Yu Qi, Chunyang Zhang, Jia Zhao,  and Song Zhao
44572-44582
Abstract  |  PDF  |  HTML  |  Order a Reprint

Circulating cell-free DNA as a prognostic and predictive biomarker in non-small cell lung cancer

Circulating cell-free DNA as a prognostic and predictive biomarker in non-small cell lung cancer

https://doi.org/10.18632/oncotarget.10069

Bo Ai, Huiquan Liu, Yu Huang,  and Ping Peng
44583-44595
Abstract  |  PDF  |  HTML  |  Order a Reprint

O-linked N-acetylglucosamine transferase promotes cervical cancer tumorigenesis through human papillomaviruses E6 and E7 oncogenes

O-linked N-acetylglucosamine transferase promotes cervical cancer tumorigenesis through human papillomaviruses E6 and E7 oncogenes

https://doi.org/10.18632/oncotarget.10112

Minjun Kim, Yoon Sook Kim, Hwajin Kim, Min Young Kang, Jeongsook Park, Dong Hoon Lee, Gu Seob Roh, Hyun Joon Kim, Sang Soo Kang, Gyeong Jae Cho, Ji Kwon Park, Jin Won Cho, Jeong Kyu Shin,  and Wan Sung Choi
44596-44607
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Comprehensive expression profiles of gastric cancer molecular subtypes by immunohistochemistry: implications for individualized therapy

Comprehensive expression profiles of gastric cancer molecular subtypes by immunohistochemistry: implications for individualized therapy

https://doi.org/10.18632/oncotarget.10115

Hyo Song Kim, Su-Jin Shin, Seung-Hoon Beom, Minkyu Jung, Yoon Young Choi, Taeil Son, Hyoung-Il Kim, Jae-Ho Cheong, Woo Jin Hyung, Sung Hoon Noh, Hyunsoo Chung, Jun Chul Park, Sung Kwan Shin, Sang Kil Lee, Yong Chan Lee, Woong Sub Koom, Joon Seok Lim, Hyun Cheol Chung, Sun Young Rha,  and Hyunki Kim
44608-44620
Abstract  |  PDF  |  HTML  |  Order a Reprint

Convergent evidence from systematic analysis of GWAS revealed genetic basis of esophageal cancer

Convergent evidence from systematic analysis of GWAS revealed genetic basis of esophageal cancer

https://doi.org/10.18632/oncotarget.10133

Xue-xin Gao, Lei Gao, Jiu-qiang Wang, Su-su Qu, Yue Qu, Hong-lei Sun, Si-dang Liu,  and Ying-li Shang
44621-44629
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Piezo2 protein: A novel regulator of tumor angiogenesis and hyperpermeability

Piezo2 protein: A novel regulator of tumor angiogenesis and hyperpermeability

https://doi.org/10.18632/oncotarget.10134

Hong Yang, Chang Liu, Rong-Mei Zhou, Jin Yao, Xiu-Miao Li, Yi Shen, Hong Cheng, Jun Yuan, Biao Yan,  and Qin Jiang
44630-44643
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Maturation of dendritic cells by pullulan promotes anti-cancer effect

Maturation of dendritic cells by pullulan promotes anti-cancer effect

https://doi.org/10.18632/oncotarget.10183

Wei Zhang, Xiaoqian Yu, Minseok Kwak, Li Xu, LiJun Zhang, Qing Yu,  and Jun-O Jin
44644-44659
Abstract  |  PDF  |  HTML  |  Order a Reprint

Clinical Research Papers

Strategies to improve treatment outcome in gastric cancer: A retrospective analysis of patients from two high-volume hospitals in Korea and China

Strategies to improve treatment outcome in gastric cancer: A retrospective analysis of patients from two high-volume hospitals in Korea and China

https://doi.org/10.18632/oncotarget.9378

Kun Yang, Yoon Young Choi, Wei-Han Zhang, Xin-Zu Chen, Mi Kyung Song, Jinae Lee, Bo Zhang, Zhi-Xin Chen, Hyoung-Il Kim, Jia-Ping Chen, Jae-Ho Cheong, Zong-Guang Zhou, Woo Jin Hyung, Jian-Kun Hu,  and Sung Hoon Noh
44660-44675
Abstract  |  PDF  |  HTML  |  Order a Reprint

Biomarker quantification by multiplexed quantum dot technology for predicting lymph node metastasis and prognosis in head and neck cancer

Biomarker quantification by multiplexed quantum dot technology for predicting lymph node metastasis and prognosis in head and neck cancer

https://doi.org/10.18632/oncotarget.9225

Zhongliang Hu, Guoqing Qian, Susan Müller, Jing Xu, Nabil F. Saba, Sungjin Kim, Zhengjia Chen, Ning Jiang, Dongsheng Wang, Hongzheng Zhang, Kristin Lane, Clifford Hoyt, Dong M. Shin,  and Zhuo Georgia Chen
44676-44685
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Concurrent cisplatin and 5-fluorouracil versus concurrent cisplatin and docetaxel with radiotherapy for esophageal squamous cell carcinoma: a propensity score-matched analysis

Concurrent cisplatin and 5-fluorouracil versus concurrent cisplatin and docetaxel with radiotherapy for esophageal squamous cell carcinoma: a propensity score-matched analysis

https://doi.org/10.18632/oncotarget.9301

Peng Zhang, Mian Xi, Qiao-Qiao Li, Yong-Hong Hu, Xiaobo Guo, Lei Zhao, Hui Liu, Shi-Liang Liu, Li-Ling Luo, Qing Liu,  and Meng-Zhong Liu
44686-44694
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Survival of patients with symptom- and screening-detected colorectal cancer

Survival of patients with symptom- and screening-detected colorectal cancer

https://doi.org/10.18632/oncotarget.9412

Hermann Brenner, Lina Jansen, Alexis Ulrich, Jenny Chang-Claude,  and Michael Hoffmeister
44695-44704
Abstract  |  PDF  |  HTML  |  Order a Reprint

Combined sequential use of HAP and ART scores to predict survival outcome and treatment failure following chemoembolization in hepatocellular carcinoma: a multi-center comparative study

Combined sequential use of HAP and ART scores to predict survival outcome and treatment failure following chemoembolization in hepatocellular carcinoma: a multi-center comparative study

https://doi.org/10.18632/oncotarget.9604

David J. Pinato, Tadaaki Arizumi, Jeong Won Jang, Elias Allara, Puvan I. Suppiah, Carlo Smirne, Paul Tait, Madhava Pai, Glenda Grossi, Young Woon Kim, Mario Pirisi, Masatoshi Kudo,  and Rohini Sharma
44705-44718
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Reviews

An overview of long non-coding RNAs in ovarian cancers

An overview of long non-coding RNAs in ovarian cancers

https://doi.org/10.18632/oncotarget.8089

Matthieu Meryet-Figuière, Bernard Lambert, Pascal Gauduchon, Nicolas Vigneron, Emilie Brotin, Laurent Poulain,  and Christophe Denoyelle
44719-44734
Abstract  |  PDF  |  HTML  |  Order a Reprint

Molecular and clinical significance of fibroblast growth factor 2 (FGF2 /bFGF) in malignancies of solid and hematological cancers for personalized therapies

Molecular and clinical significance of fibroblast growth factor 2 (FGF2 /bFGF) in malignancies of solid and hematological cancers for personalized therapies

https://doi.org/10.18632/oncotarget.8203

Mohamed R. Akl, Poonam Nagpal, Nehad M. Ayoub, Betty Tai, Sathyen A. Prabhu, Catherine M. Capac, Matthew Gliksman, Andre Goy,  and K. Stephen Suh
44735-44762
Abstract  |  PDF  |  HTML  |  Order a Reprint

Cell apoptosis, autophagy and necroptosis in osteosarcoma treatment

Cell apoptosis, autophagy and necroptosis in osteosarcoma treatment

https://doi.org/10.18632/oncotarget.8206

Jing Li, Zuozhang Yang, Yi Li, Junfeng Xia, Dongqi Li, Huiling Li, Mingyan Ren, Yedan Liao, Shunling Yu, Yanjin Chen, Yihao Yang,  and Ya Zhang
44763-44778
Abstract  |  PDF  |  HTML  |  Order a Reprint

From kinetics and cellular cooperations to cancer immunotherapies

From kinetics and cellular cooperations to cancer immunotherapies

https://doi.org/10.18632/oncotarget.8242

Alain Trautmann
44779-44789
Abstract  |  PDF  |  HTML  |  Order a Reprint

Anticancer properties of nimbolide and pharmacokinetic considerations to accelerate its development

Anticancer properties of nimbolide and pharmacokinetic considerations to accelerate its development

https://doi.org/10.18632/oncotarget.8316

Lingzhi Wang, Do Dang Khoa Phan, Jingwen Zhang, Pei-Shi Ong, Win Lwin Thuya, Ross Soo, Andrea Li-Ann Wong, Wei Peng Yong, Soo Chin Lee, Paul Chi-Lui Ho, Gautam Sethi,  and Boon Cher Goh
44790-44802
Abstract  |  PDF  |  HTML  |  Order a Reprint

A systematic review on in vitro 3D bone metastases models: A new horizon to recapitulate the native clinical scenario?

A systematic review on in vitro 3D bone metastases models: A new horizon to recapitulate the native clinical scenario?

https://doi.org/10.18632/oncotarget.8394

Francesca Salamanna, Deyanira Contartese, Melania Maglio,  and Milena Fini
44803-44820
Abstract  |  PDF  |  HTML  |  Order a Reprint

Molecules that target nucleophosmin for cancer treatment: an update

Molecules that target nucleophosmin for cancer treatment: an update

https://doi.org/10.18632/oncotarget.8599

Adele Di Matteo, Mimma Franceschini, Sara Chiarella, Serena Rocchio, Carlo Travaglini-Allocatelli,  and Luca Federici
44821-44840
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How do the results of the RADIANT trials impact on the management of NET patients? A systematic review of published studies

How do the results of the RADIANT trials impact on the management of NET patients? A systematic review of published studies

https://doi.org/10.18632/oncotarget.8601

Sara Pusceddu, Filippo De Braud, Giuseppe Lo Russo, Laura Concas, Daniela Femia, Claudio Vernieri, Alice Indini, Barbara Formisano,  and Roberto Buzzoni
44841-44847
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Ubiquitin-specific peptidase 22 functions and its involvement in disease

Ubiquitin-specific peptidase 22 functions and its involvement in disease

https://doi.org/10.18632/oncotarget.8602

Johanna Melo-Cardenas, Yusi Zhang, Donna D. Zhang,  and Deyu Fang
44848-44856
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Wait-and-see treatment strategies for rectal cancer patients with clinical complete response after neoadjuvant chemoradiotherapy: a systematic review and meta-analysis

Wait-and-see treatment strategies for rectal cancer patients with clinical complete response after neoadjuvant chemoradiotherapy: a systematic review and meta-analysis

https://doi.org/10.18632/oncotarget.8622

Jun Li, Lunjin Li, Lin Yang, Jiatian Yuan, Bo Lv, Yanan Yao,  and Shasha Xing
44857-44870
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