Oncotarget

Vol 7, No 26

June 28, 2016

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Targeting MUC1-C with GO-203 downregulates DNMT1 expression and synergistically enhances decitabine induced cell death in primary AML cells.See Tagde et al.

Table of Contents

Priority Research Papers

MUC1-C induces DNA methyltransferase 1 and represses tumor suppressor genes in acute myeloid leukemia

MUC1-C induces DNA methyltransferase 1 and represses tumor suppressor genes in acute myeloid leukemia

https://doi.org/10.18632/oncotarget.9777

Ashujit Tagde, Hasan Rajabi, Dina Stroopinsky, Reddy Gali, Maroof Alam, Audrey Bouillez, Surender Kharbanda, Richard Stone, David Avigan,  and Donald Kufe
38974-38987
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Research Papers: Gerotarget (Focus on Aging)

Long term effects of radiation exposure on telomere lengths of leukocytes and its associated biomarkers among atomic-bomb survivors

Long term effects of radiation exposure on telomere lengths of leukocytes and its associated biomarkers among atomic-bomb survivors

https://doi.org/10.18632/oncotarget.8801

Ana Lustig, Ivo Shterev, Susan Geyer, Alvin Shi, Yiqun Hu, Yukari Morishita, Hiroko Nagamura, Keiko Sasaki, Mayumi Maki, Ikue Hayashi, Kyoji Furukawa, Kengo Yoshida, Junko Kajimura, Seishi Kyoizumi, Yoichiro Kusunoki, Waka Ohishi, Kei Nakachi, Nan-ping Weng,  and Tomonori Hayashi
38988-38998
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Alzheimer disease research in the 21st century: past and current failures, new perspectives and funding priorities

Alzheimer disease research in the 21st century: past and current failures, new perspectives and funding priorities

https://doi.org/10.18632/oncotarget.9175

Francesca Pistollato, Elan L. Ohayon, Ann Lam, Gillian R. Langley, Thomas J. Novak, David Pamies, George Perry, Eugenia Trushina, Robin S.B. Williams, Alex E. Roher, Thomas Hartung, Stevan Harnad, Neal Barnard, Martha Clare Morris, Mei-Chun Lai, Ryan Merkley,  and P. Charukeshi Chandrasekera
38999-39016
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Environmental tobacco smoke increases autophagic effects but decreases longevity associated with Sirt-1 protein expression in young C57BL mice hearts

Environmental tobacco smoke increases autophagic effects but decreases longevity associated with Sirt-1 protein expression in young C57BL mice hearts

https://doi.org/10.18632/oncotarget.9176

Wei-Jen Ting, Jaw-Ji Yang, Chia-Hua Kuo, Zi-Jun Xiao, Xin-Ze Lu, Yu-Lan Yeh, Cecilia-Hsuan Day, Su-Ying Wen, Vijaya PadmaViswanadha, Chong-He Jiang, Wei-Wen Kuo,  and Chih-Yang Huang
39017-39025
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De novo HAPLN1 expression hallmarks Wnt-induced stem cell and fibrogenic networks leading to aggressive human hepatocellular carcinomas

De novo HAPLN1 expression hallmarks Wnt-induced stem cell and fibrogenic networks leading to aggressive human hepatocellular carcinomas

https://doi.org/10.18632/oncotarget.9346

Sihem Mebarki, Romain Désert, Laurent Sulpice, Marie Sicard, Mireille Desille, Frédéric Canal, Hélène Dubois-Pot Schneider, Damien Bergeat, Bruno Turlin, Pascale Bellaud, Elise Lavergne, Rémy Le Guével, Anne Corlu, Christine Perret, Cédric Coulouarn, Bruno Clément,  and Orlando Musso
39026-39043
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

FERMT2 rs17125944 polymorphism with Alzheimer’s disease risk: a replication and meta-analysis

FERMT2 rs17125944 polymorphism with Alzheimer’s disease risk: a replication and meta-analysis

https://doi.org/10.18632/oncotarget.9679

Qiu-Yue Zhang, Hui-Fu Wang, Zhan-Jie Zheng, Ling-Li Kong, Meng-Shan Tan, Chen-Chen Tan, Wei Zhang, Zi-Xuan Wang, Lin Tan, Jin-Tai Yu,  and Lan Tan
39044-39050
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Conditioned medium derived from rat amniotic epithelial cells confers protection against inflammation, cancer, and senescence

Conditioned medium derived from rat amniotic epithelial cells confers protection against inflammation, cancer, and senescence

https://doi.org/10.18632/oncotarget.9694

Clara Di Germanio, Michel Bernier, Michael Petr, Mauro Mattioli, Barbara Barboni,  and Rafael de Cabo
39051-39064
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Endothelial SIRT1 prevents adverse arterial remodeling by facilitating HERC2-mediated degradation of acetylated LKB1

Endothelial SIRT1 prevents adverse arterial remodeling by facilitating HERC2-mediated degradation of acetylated LKB1

https://doi.org/10.18632/oncotarget.9687

Bo Bai, Andy W.C. Man, Kangmin Yang, Yumeng Guo, Cheng Xu, Hung-Fat Tse, Weiping Han, Maria Bloksgaard, Jo G.R. De Mey, Paul M. Vanhoutte, Aimin Xu,  and Yu Wang
39065-39081
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Run-on of germline apoptosis promotes gonad senescence in C. elegans

Run-on of germline apoptosis promotes gonad senescence in C. elegans

https://doi.org/10.18632/oncotarget.9681

Yila de la Guardia, Ann F. Gilliat, Josephine Hellberg, Peter Rennert, Filipe Cabreiro,  and David Gems
39082-39096
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Estrogen receptor alpha inhibits senescence-like phenotype and facilitates transformation induced by oncogenic ras in human mammary epithelial cells

Estrogen receptor alpha inhibits senescence-like phenotype and facilitates transformation induced by oncogenic ras in human mammary epithelial cells

https://doi.org/10.18632/oncotarget.9772

Zhao Liu, Long Wang, Junhua Yang, Abhik Bandyopadhyay, Virginia Kaklamani, Shui Wang,  and Lu-Zhe Sun
39097-39107
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Careful neuropsychological testing reveals a novel genetic marker, GSTO1*C, linked to the pre-stage of Alzheimer’s disease

Careful neuropsychological testing reveals a novel genetic marker, GSTO1*C, linked to the pre-stage of Alzheimer’s disease

https://doi.org/10.18632/oncotarget.9773

Ellen Umlauf, Eduard Rappold, Bettina Schiller, Petra Fuchs, Michael Rainer, Brigitte Wolf,  and Maria Zellner
39108-39117
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Positive and negative early life experiences differentially modulate long term survival and amyloid protein levels in a mouse model of Alzheimer’s disease

Positive and negative early life experiences differentially modulate long term survival and amyloid protein levels in a mouse model of Alzheimer’s disease

https://doi.org/10.18632/oncotarget.9776

Sylvie L. Lesuis, Herve Maurin, Peter Borghgraef, Paul J. Lucassen, Fred Van Leuven,  and Harm J. Krugers
39118-39135
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MEF2C rs190982 polymorphism with late-onset Alzheimer’s disease in Han Chinese: A replication study and meta-analyses

MEF2C rs190982 polymorphism with late-onset Alzheimer’s disease in Han Chinese: A replication study and meta-analyses

https://doi.org/10.18632/oncotarget.9819

Shan-Shan Tang, Hui-Fu Wang, Wei Zhang, Ling-Li Kong, Zhan-Jie Zheng, Meng-Shan Tan, Chen-Chen Tan, Zi-Xuan Wang, Lin Tan, Teng Jiang, Jin-Tai Yu,  and Lan Tan
39136-39142
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Age-related increase of thromboxane B2 and risk of cardiovascular disease in atrial fibrillation

Age-related increase of thromboxane B2 and risk of cardiovascular disease in atrial fibrillation

https://doi.org/10.18632/oncotarget.9826

Daniele Pastori, Pasquale Pignatelli, Alessio Farcomeni, Cristina Nocella, Simona Bartimoccia, Roberto Carnevale,  and Francesco Violi
39143-39147
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Transient enhancement of proliferation of neural progenitors and impairment of their long-term survival in p25 transgenic mice

Transient enhancement of proliferation of neural progenitors and impairment of their long-term survival in p25 transgenic mice

https://doi.org/10.18632/oncotarget.9834

Donghua Zou, Yijing Zhou, Long Liu, Fengping Dong, Tianzhi Shu, Ying Zhou, Li-Huei Tsai,  and Yingwei Mao
39148-39161
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Inhibition of DNA methyltransferase 1 increases nuclear receptor subfamily 4 group A member 1 expression and decreases blood glucose in type 2 diabetes

Inhibition of DNA methyltransferase 1 increases nuclear receptor subfamily 4 group A member 1 expression and decreases blood glucose in type 2 diabetes

https://doi.org/10.18632/oncotarget.10043

Yng-Tay Chen, Jiunn-Wang Liao, Ya-Ching Tsai,  and Fuu-Jen Tsai
39162-39170
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

IL-2 and IL-6 cooperate to enhance the generation of influenza-specific CD8 T cells responding to live influenza virus in aged mice and humans

IL-2 and IL-6 cooperate to enhance the generation of influenza-specific CD8 T cells responding to live influenza virus in aged mice and humans

https://doi.org/10.18632/oncotarget.10047

Xin Zhou, Jacob W. Hopkins, Chongkai Wang, Vinayak Brahmakshatriya, Susan L. Swain, George A. Kuchel, Laura Haynes,  and Janet E. McElhaney
39171-39183
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Research Papers: Pathology

PRRT2 mutations lead to neuronal dysfunction and neurodevelopmental defects

PRRT2 mutations lead to neuronal dysfunction and neurodevelopmental defects

https://doi.org/10.18632/oncotarget.9258

Yo-Tsen Liu, Fang-Shin Nian, Wan-Ju Chou, Chin-Yin Tai, Shang-Yeong Kwan, Chien Chen, Pei-Wen Kuo, Po-Hsi Lin, Chin-Yi Chen, Chia-Wei Huang, Yi-Chung Lee, Bing-Wen Soong,  and Jin-Wu Tsai
39184-39196
Abstract  |  PDF  |  HTML  |  Order a Reprint

Clinicopathological and immunohistochemical characterization of papillary proliferation of the endometrium: A single institutional experience

Clinicopathological and immunohistochemical characterization of papillary proliferation of the endometrium: A single institutional experience

https://doi.org/10.18632/oncotarget.10049

Cheol Keun Park, Gun Yoon, Yoon Ah Cho,  and Hyun-Soo Kim
39197-39206
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TSH inhibits SERCA2a and the PKA/PLN pathway in rat cardiomyocytes

TSH inhibits SERCA2a and the PKA/PLN pathway in rat cardiomyocytes

https://doi.org/10.18632/oncotarget.9393

Jiajia Dong, Cuixia Gao, Jing Liu, Yunshan Cao,  and Limin Tian
39207-39215
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The comprehensive summary of surgical versus non-surgical treatment for obesity: a systematic review and meta-analysis of randomized controlled trials

The comprehensive summary of surgical versus non-surgical treatment for obesity: a systematic review and meta-analysis of randomized controlled trials

https://doi.org/10.18632/oncotarget.9581

Ji Cheng, Jinbo Gao, Xiaoming Shuai, Guobin Wang,  and Kaixiong Tao
39216-39230
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The associations between serum biomarkers and stenosis of the coronary arteries

The associations between serum biomarkers and stenosis of the coronary arteries

https://doi.org/10.18632/oncotarget.9645

Lei Feng, Shiyan Nian, Shu Zhang, Wenbo Xu, Xingfeng Zhang, Dan Ye,  and Lei Zheng
39231-39240
Abstract  |  PDF  |  HTML  |  Order a Reprint

Prognostic relevance of autophagy markers LC3B and p62 in esophageal adenocarcinomas

Prognostic relevance of autophagy markers LC3B and p62 in esophageal adenocarcinomas

https://doi.org/10.18632/oncotarget.9649

Olivia Adams, Bastian Dislich, Sabina Berezowska, Anna M. Schläfli, Christian A. Seiler, Dino Kroell, Mario P. Tschan,  and Rupert Langer
39241-39255
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Dendritic cell-derived VEGF-A plays a role in inflammatory angiogenesis of human secondary lymphoid organs and is driven by the coordinated activation of multiple transcription factors

Dendritic cell-derived VEGF-A plays a role in inflammatory angiogenesis of human secondary lymphoid organs and is driven by the coordinated activation of multiple transcription factors

https://doi.org/10.18632/oncotarget.9684

Valentina Salvi, William Vermi, Veronica Gianello, Silvia Lonardi, Vincenzo Gagliostro, Antonella Naldini, Silvano Sozzani,  and Daniela Bosisio
39256-39269
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Toxicological assessment of multi-walled carbon nanotubes in vitro: potential mitochondria effects on male reproductive cells

Toxicological assessment of multi-walled carbon nanotubes in vitro: potential mitochondria effects on male reproductive cells

https://doi.org/10.18632/oncotarget.9689

Cheng Xu, Qian Liu, Hui Liu, Chunlan Zhang, Wentao Shao,  and Aihua Gu
39270-39278
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

ATG4A promotes tumor metastasis by inducing the epithelial-mesenchymal transition and stem-like properties in gastric cells

ATG4A promotes tumor metastasis by inducing the epithelial-mesenchymal transition and stem-like properties in gastric cells

https://doi.org/10.18632/oncotarget.9827

Shi-Wei Yang, Yi-Fang Ping, Yu-Xing Jiang, Xiao Luo, Xia Zhang, Xiu-Wu Bian,  and Pei-Wu Yu
39279-39292
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Mutations of KRAS, NRAS, BRAF, EGFR, and PIK3CA genes in urachal carcinoma: Occurence and prognostic significance

Mutations of KRAS, NRAS, BRAF, EGFR, and PIK3CA genes in urachal carcinoma: Occurence and prognostic significance

https://doi.org/10.18632/oncotarget.9828

Orsolya Módos, Henning Reis, Christian Niedworok, Herbert Rübben, Attila Szendröi, Marcell A. Szász, József Tímár, Kornélia Baghy, Ilona Kovalszky, Tomasz Golabek, Piotr Chlosta, Krzysztof Okon, Benoit Peyronnet, Romain Mathieu, Shahrokh F. Shariat, Péter Hollósi, Péter Nyirády,  and Tibor Szarvas
39293-39301
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Treatment of diabetes mellitus-induced erectile dysfunction using endothelial progenitor cells genetically modified with human telomerase reverse transcriptase

Treatment of diabetes mellitus-induced erectile dysfunction using endothelial progenitor cells genetically modified with human telomerase reverse transcriptase

https://doi.org/10.18632/oncotarget.9909

Yan Zhang, Zhi Chen, Tao Wang, Jun Yang, Rui Li, Shaogang Wang, Jihong Liu,  and Zhangqun Ye
39302-39315
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Activation of NLRP3 inflammasomes in mouse hepatic stellate cells during Schistosoma J. infection

Activation of NLRP3 inflammasomes in mouse hepatic stellate cells during Schistosoma J. infection

https://doi.org/10.18632/oncotarget.10044

Nan Meng, Min Xia, Ya-Qi Lu, Mi Wang, Krishna M. Boini, Pin-Lan Li,  and Wang-Xian Tang
39316-39331
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Analysis of the correlation between lipotoxicity and pituitary-thyroid axis hormone levels in men and male rats

Analysis of the correlation between lipotoxicity and pituitary-thyroid axis hormone levels in men and male rats

https://doi.org/10.18632/oncotarget.10045

Jianmei Yang, Xiaoming Zhou, Xu Zhang, Jianting Hu, Ling Gao, Yongfeng Song, Chunxiao Yu, Shanshan Shao, Zhongshang Yuan, Yan Sun, Huili Yan, Guimei Li,  and Jiajun Zhao
39332-39344
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Activation of volume-sensitive Cl- channel mediates autophagy-related cell death in myocardial ischaemia/reperfusion injury

Activation of volume-sensitive Cl- channel mediates autophagy-related cell death in myocardial ischaemia/reperfusion injury

https://doi.org/10.18632/oncotarget.10050

Yuesheng Xia, Yan Liu, Tong Xia, Xing Li, Cong Huo, Xin Jia, Lin Wang, Rong Xu, Ning Wang, Mingming Zhang, Hong Li,  and Xiaoming Wang
39345-39362
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Research Papers: Immunology

Modulation of macrophage polarization and lung cancer cell stemness by MUC1 and development of a related small-molecule inhibitor pterostilbene

Modulation of macrophage polarization and lung cancer cell stemness by MUC1 and development of a related small-molecule inhibitor pterostilbene

https://doi.org/10.18632/oncotarget.8101

Wen-Chien Huang, Mei-Lin Chan, Ming-Jen Chen, Tung-Hu Tsai,  and Yu-Jen Chen
39363-39375
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Immunoproteomic identification of MbovP579, a promising diagnostic biomarker for serological detection of Mycoplasma bovis infection

Immunoproteomic identification of MbovP579, a promising diagnostic biomarker for serological detection of Mycoplasma bovis infection

https://doi.org/10.18632/oncotarget.9799

Farhan Anwar Khan, Muhammad Faisal, Jin Chao, Kai Liu, Xi Chen, Gang Zhao, Harish Menghwar, Hui Zhang, Xifang Zhu, Muhammad Asif Rasheed, Chenfei He, Changmin Hu, Yingyu Chen, Eric Baranowski, Huanchun Chen,  and Aizhen Guo
39376-39395
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Schlafen2 mutation unravels a role for chronic ER stress in the loss of T cell quiescence

Schlafen2 mutation unravels a role for chronic ER stress in the loss of T cell quiescence

https://doi.org/10.18632/oncotarget.9818

Ibrahim Omar, Antonio Lapenna, Leonor Cohen-Daniel, Boaz Tirosh,  and Michael Berger
39396-39407
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Immunoglobulin G promotes skin graft acceptance in an immunologically potent rat model

Immunoglobulin G promotes skin graft acceptance in an immunologically potent rat model

https://doi.org/10.18632/oncotarget.9823

Xingmu Liu, Tao Huang, Xueling Chen, Meiling Yan, Feiyuan Yu, Huan Gu, Chao He,  and Jiang Gu
39408-39420
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Lymphatic endothelial cells attenuate inflammation via suppression of dendritic cell maturation

Lymphatic endothelial cells attenuate inflammation via suppression of dendritic cell maturation

https://doi.org/10.18632/oncotarget.9820

Ailsa J. Christiansen, Lothar C. Dieterich, Isabel Ohs, Samia B. Bachmann, Roberta Bianchi, Steven T. Proulx, Maija Hollmén, David Aebischer,  and Michael Detmar
39421-39435
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Association of FCGR2A rs1801274 polymorphism with susceptibility to autoimmune diseases: A meta-analysis

Association of FCGR2A rs1801274 polymorphism with susceptibility to autoimmune diseases: A meta-analysis

https://doi.org/10.18632/oncotarget.9831

Chang’e Zhang, Wenju Wang, Hong’e Zhang, Lulu Wei,  and Shuping Guo
39436-39443
Abstract  |  PDF  |  HTML  |  Order a Reprint

Research Papers: Neuroscience

5d, a novel analogue of 3-n-butylphthalide, decreases NADPH oxidase activity through the positive regulation of CK2 after ischemia/reperfusion injury

5d, a novel analogue of 3-n-butylphthalide, decreases NADPH oxidase activity through the positive regulation of CK2 after ischemia/reperfusion injury

https://doi.org/10.18632/oncotarget.8548

Jia Zhou, Yi-hua Zhang, Hui-zhu Song, Hui Ji, Xiao-li Wang, Lei Wang, Jun Qian, Jing-jing Ling,  and Feng-feng Ping
39444-39457
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Research Papers

Reactivation of Smac-mediated apoptosis in chronic lymphocytic leukemia cells: mechanistic studies of Smac mimetic

Reactivation of Smac-mediated apoptosis in chronic lymphocytic leukemia cells: mechanistic studies of Smac mimetic

https://doi.org/10.18632/oncotarget.8462

Kumudha Balakrishnan, Min Fu, Francesco Onida, William G. Wierda, Michael J. Keating,  and Varsha Gandhi
39458-39472
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Mitochondrial oxidative phosphorylation controls cancer cell’s life and death decisions upon exposure to MAPK inhibitors

Mitochondrial oxidative phosphorylation controls cancer cell’s life and death decisions upon exposure to MAPK inhibitors

https://doi.org/10.18632/oncotarget.7790

Paola Corazao-Rozas, Pierre Guerreschi, Fanny André, Pierre-Elliott Gabert, Steve Lancel, Salim Dekiouk, Delphine Fontaine, Meryem Tardivel, Ariel Savina, Bruno Quesnel, Laurent Mortier, Philippe Marchetti,  and Jérome Kluza
39473-39485
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Heparanase expression upregulates platelet adhesion activity and thrombogenicity

Heparanase expression upregulates platelet adhesion activity and thrombogenicity

https://doi.org/10.18632/oncotarget.8960

Hao Cui, Ying-xia Tan, Cecilia Österholm, Xiao Zhang, Ulf Hedin, Israel Vlodavsky,  and Jin-Ping Li
39486-39496
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Paeonol protects endotoxin-induced acute kidney injury: potential mechanism of inhibiting TLR4-NF-κB signal pathway

Paeonol protects endotoxin-induced acute kidney injury: potential mechanism of inhibiting TLR4-NF-κB signal pathway

https://doi.org/10.18632/oncotarget.8347

Hua-Ying Fan, Dong Qi, Chen Yu, Feng Zhao, Tao Liu, Zuo-Kai Zhang, Ming-Yan Yang, Lei-Ming Zhang, Da-Quan Chen,  and Yuan Du
39497-39510
Abstract  |  PDF  |  HTML  |  Order a Reprint

MicroRNA-26b inhibits tumor metastasis by targeting the KPNA2/c-jun pathway in human gastric cancer

MicroRNA-26b inhibits tumor metastasis by targeting the KPNA2/c-jun pathway in human gastric cancer

https://doi.org/10.18632/oncotarget.8629

Ming-Ming Tsai, Hsiang-Wei Huang, Chia-Siu Wang, Kam-Fai Lee, Chung-Ying Tsai, Pei-Hsuan Lu, Hsiang-Cheng Chi, Yang-Hsiang Lin, Liang-Mou Kuo,  and Kwang-Huei Lin
39511-39526
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

miR-590 promotes cell proliferation and invasion in T-cell acute lymphoblastic leukaemia by inhibiting RB1

miR-590 promotes cell proliferation and invasion in T-cell acute lymphoblastic leukaemia by inhibiting RB1

https://doi.org/10.18632/oncotarget.8414

Mei-hua Miao, Xue-qiang Ji, Hao Zhang, Jun Xu, Hong Zhu,  and Xue-jun Shao
39527-39534
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Plasma dynamic monitoring of soluble c-Met level for EGFR-TKI treatment in advanced non-small cell lung cancer

Plasma dynamic monitoring of soluble c-Met level for EGFR-TKI treatment in advanced non-small cell lung cancer

https://doi.org/10.18632/oncotarget.9425

Hong-Fei Gao, Jin-Ji Yang, Zhi-Hong Chen, Xu-Chao Zhang, Hong-Hong Yan, Wei-Bang Guo, Qing Zhou, Lou-Ying Gou, Zhong-Yi Dong,  and Yi-Long Wu
39535-39543
Abstract  |  PDF  |  HTML  |  Order a Reprint

Prognostic value of the autophagy markers LC3 and p62/SQSTM1 in early-stage non-small cell lung cancer

Prognostic value of the autophagy markers LC3 and p62/SQSTM1 in early-stage non-small cell lung cancer

https://doi.org/10.18632/oncotarget.9647

Anna M. Schläfli, Olivia Adams, José A. Galván, Mathias Gugger, Spasenija Savic, Lukas Bubendorf, Ralph A. Schmid, Karl-Friedrich Becker, Mario P. Tschan, Rupert Langer,  and Sabina Berezowska
39544-39555
Abstract  |  PDF  |  HTML  |  Order a Reprint

Cytoplasmic, full length and novel cleaved variant, TBLR1 reduces apoptosis in prostate cancer under androgen deprivation

Cytoplasmic, full length and novel cleaved variant, TBLR1 reduces apoptosis in prostate cancer under androgen deprivation

https://doi.org/10.18632/oncotarget.9005

Garrett Daniels, Xinmin Zhang, Xuelin Zhong, Larion Santiago, Ling Hang Wang, Xinyu Wu, Jack Y. Zhang, Fengxia Liang, Xin Li, Thomas A. Neubert, Laurey Steinke, Ying Shen, Ross Basch, Robert Schneider, David E. Levy,  and Peng Lee
39556-39571
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Polymorphisms in the CHIT1 gene: Associations with colorectal cancer

Polymorphisms in the CHIT1 gene: Associations with colorectal cancer

https://doi.org/10.18632/oncotarget.9138

Fei-Feng Li, Peng Yan, Zhi-Xun Zhao, Zheng Liu, Da-Wei Song, Xing-Wang Zhao, Xi-Shan Wang, Gui-Yu Wang,  and Shu-Lin Liu
39572-39581
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The effect of celecoxib on tumor growth in ovarian cancer cells and a genetically engineered mouse model of serous ovarian cancer

The effect of celecoxib on tumor growth in ovarian cancer cells and a genetically engineered mouse model of serous ovarian cancer

https://doi.org/10.18632/oncotarget.8659

Anuj Suri, Xiugui Sheng, Kevin M. Schuler, Yan Zhong, Xiaoyun Han, Hannah M. Jones, Paola A. Gehrig, Chunxiao Zhou,  and Victoria L. Bae-Jump
39582-39594
Abstract  |  PDF  |  HTML  |  Order a Reprint

Efficacy of the combination of MEK and CDK4/6 inhibitors in vitro and in vivo in KRAS mutant colorectal cancer models

Efficacy of the combination of MEK and CDK4/6 inhibitors in vitro and in vivo in KRAS mutant colorectal cancer models

https://doi.org/10.18632/oncotarget.9153

Michael S. Lee, Timothy L. Helms, Ningping Feng, Jason Gay, Qing Edward Chang, Feng Tian, Ji Y. Wu, Carlo Toniatti, Timothy P. Heffernan, Garth Powis, Lawrence N. Kwong,  and Scott Kopetz
39595-39608
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Molecular and proteomic insight into Notch1 characterization in hepatocellular carcinoma

Molecular and proteomic insight into Notch1 characterization in hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.9203

Catia Giovannini, Manuela Minguzzi, Filippo Genovese, Michele Baglioni, Alessandra Gualandi, Matteo Ravaioli, Maddalena Milazzo, Simona Tavolari, Luigi Bolondi,  and Laura Gramantieri
39609-39626
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Interference with mutagenic aflatoxin B1-induced checkpoints through antagonistic action of ochratoxin A in intestinal cancer cells: a molecular explanation on potential risk of crosstalk between carcinogens

Interference with mutagenic aflatoxin B1-induced checkpoints through antagonistic action of ochratoxin A in intestinal cancer cells: a molecular explanation on potential risk of crosstalk between carcinogens

https://doi.org/10.18632/oncotarget.8914

Juil Kim, Seong-Hwan Park, Kee Hun Do, Dongwook Kim,  and Yuseok Moon
39627-39639
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Small RNAs and the competing endogenous RNA network in high grade serous ovarian cancer tumor spread

Small RNAs and the competing endogenous RNA network in high grade serous ovarian cancer tumor spread

https://doi.org/10.18632/oncotarget.9243

Anna Bachmayr-Heyda, Katharina Auer, Nyamdelger Sukhbaatar, Stefanie Aust, Simon Deycmar, Agnes T. Reiner, Stephan Polterauer, Sabine Dekan,  and Dietmar Pils
39640-39653
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Minimal contribution of ERK1/2-MAPK signalling towards the maintenance of oncogenic GNAQQ209P-driven uveal melanomas in zebrafish

Minimal contribution of ERK1/2-MAPK signalling towards the maintenance of oncogenic GNAQQ209P-driven uveal melanomas in zebrafish

https://doi.org/10.18632/oncotarget.9207

Mai Abdel Mouti, Christopher Dee, Sarah E. Coupland,  and Adam F.L. Hurlstone
39654-39670
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Programmed death-ligand-1 expression in advanced gastric cancer detected with RNA in situ hybridization and its clinical significance

Programmed death-ligand-1 expression in advanced gastric cancer detected with RNA in situ hybridization and its clinical significance

https://doi.org/10.18632/oncotarget.9381

Jiajia Yuan, Jie Zhang, Yan Zhu, Na Li, Tiantian Tian, Yang Li, Yanyan Li, Zhongwu Li, Yumei Lai, Jing Gao,  and Lin Shen
39671-39679
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MiR-193a-5p/ERBB2 act as concurrent chemoradiation therapy response indicator of esophageal squamous cell carcinoma

MiR-193a-5p/ERBB2 act as concurrent chemoradiation therapy response indicator of esophageal squamous cell carcinoma

https://doi.org/10.18632/oncotarget.9444

Cheng-Han Lin, Chen-Hsun Tsai, Ching-Tung Yeh, Jui-Lin Liang, Wan-Chun Hung, Forn-Chia Lin, Wei-Lun Chang, Hao-Yi Li, Yun-Chin Yao, Tai-I Hsu, Yu-Cheng Lee, Yi-Ching Wang, Bor-Shyang Sheu, Wu-Wei Lai, Marcus J. Calkins, Michael Hsiao,  and Pei-Jung Lu
39680-39693
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Pinin associates with prognosis of hepatocellular carcinoma through promoting cell proliferation and suppressing glucose deprivation-induced apoptosis

Pinin associates with prognosis of hepatocellular carcinoma through promoting cell proliferation and suppressing glucose deprivation-induced apoptosis

https://doi.org/10.18632/oncotarget.9233

Xuejun Yang, Deguang Sun, Chengyong Dong, Yu Tian, Zhenming Gao,  and Liming Wang
39694-39704
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Autophagic flux is highly active in early mitosis and differentially regulated throughout the cell cycle

Autophagic flux is highly active in early mitosis and differentially regulated throughout the cell cycle

https://doi.org/10.18632/oncotarget.9451

Zhiyuan Li, Xinmiao Ji, Dongmei Wang, Juanjuan Liu,  and Xin Zhang
39705-39718
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Homeobox protein VentX induces p53-independent apoptosis in cancer cells

Homeobox protein VentX induces p53-independent apoptosis in cancer cells

https://doi.org/10.18632/oncotarget.9238

Hong Gao, Bin Wu, Yi Le,  and Zhenglun Zhu
39719-39729
Abstract  |  PDF  |  HTML  |  Order a Reprint

MEK inhibitor PD0325901 and vitamin C synergistically induce hypomethylation of mouse embryonic stem cells

MEK inhibitor PD0325901 and vitamin C synergistically induce hypomethylation of mouse embryonic stem cells

https://doi.org/10.18632/oncotarget.9452

Cuiping Li, Baodong Liu, Shangwei Zhong,  and Hailin Wang
39730-39739
Abstract  |  PDF  |  HTML  |  Order a Reprint

Down-regulation of microRNA-320 suppresses cardiomyocyte apoptosis and protects against myocardial ischemia and reperfusion injury by targeting IGF-1

Down-regulation of microRNA-320 suppresses cardiomyocyte apoptosis and protects against myocardial ischemia and reperfusion injury by targeting IGF-1

https://doi.org/10.18632/oncotarget.9240

Chun-Li Song, Bin Liu, Hong-Ying Diao, Yong-Feng Shi, Ji-Chang Zhang, Yang-Xue Li, Ning Liu, Yun-Peng Yu, Guan Wang, Jin-Peng Wang,  and Qian Li
39740-39757
Abstract  |  PDF  |  HTML  |  Order a Reprint

The chronological sequence of somatic mutations in early gastric carcinogenesis inferred from multiregion sequencing of gastric adenomas

The chronological sequence of somatic mutations in early gastric carcinogenesis inferred from multiregion sequencing of gastric adenomas

https://doi.org/10.18632/oncotarget.9250

Chul-Hyun Lim, Yu Kyung Cho, Sang Woo Kim, Myung-Gyu Choi, Je-Keun Rhee, Yeun-Jun Chung, Sug-Hyung Lee,  and Tae-Min Kim
39758-39767
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Tumor-selective replication herpes simplex virus-based technology significantly improves clinical detection and prognostication of viable circulating tumor cells

Tumor-selective replication herpes simplex virus-based technology significantly improves clinical detection and prognostication of viable circulating tumor cells

https://doi.org/10.18632/oncotarget.9465

Wen Zhang, Li Bao, Shaoxing Yang, Zhaoyang Qian, Mei Dong, Liyuan Yin, Qian Zhao, Keli Ge, Zhenling Deng, Jing Zhang, Fei Qi, Zhongxue An, Yuan Yu, Qingbo Wang, Renhua Wu, Fan Fan, Lianfeng Zhang, Xiping Chen, Yingjian Na, Lin Feng, Lingling liu, Yujie Zhu, Tiancheng Qin, Shuren Zhang, Youhui Zhang, Xiuqing Zhang, Jian Wang, Xin Yi, Liqun Zou, Hong-Wu Xin, Henrik J. Ditzel, Hongjun Gao, Kaitai Zhang, Binlei Liu,  and Shujun Cheng
39768-39783
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Targeting PI3Kδ and PI3Kγ signalling disrupts human AML survival and bone marrow stromal cell mediated protection

Targeting PI3Kδ and PI3Kγ signalling disrupts human AML survival and bone marrow stromal cell mediated protection

https://doi.org/10.18632/oncotarget.9289

Genevra Pillinger, Niamh V. Loughran, Rachel E. Piddock, Manar S. Shafat, Lyubov Zaitseva, Amina Abdul-Aziz, Matthew J. Lawes, Kristian M. Bowles,  and Stuart A. Rushworth
39784-39795
Abstract  |  PDF  |  HTML  |  Order a Reprint

Inhibition of EHMT2/G9a epigenetically increases the transcription of Beclin-1 via an increase in ROS and activation of NF-κB

Inhibition of EHMT2/G9a epigenetically increases the transcription of Beclin-1 via an increase in ROS and activation of NF-κB

https://doi.org/10.18632/oncotarget.9290

Sang Eun Park, Hye Jin Yi, Nayoung Suh, Yun-Yong Park, Jae-Young Koh, Seong-Yun Jeong, Dong-Hyung Cho, Choung-Soo Kim,  and Jung Jin Hwang
39796-39808
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Pharmacometabolomics study identifies circulating spermidine and tryptophan as potential biomarkers associated with the complete pathological response to trastuzumab-paclitaxel neoadjuvant therapy in HER-2 positive breast cancer

Pharmacometabolomics study identifies circulating spermidine and tryptophan as potential biomarkers associated with the complete pathological response to trastuzumab-paclitaxel neoadjuvant therapy in HER-2 positive breast cancer

https://doi.org/10.18632/oncotarget.9489

Gianmaria Miolo, Elena Muraro, Donatella Caruso, Diana Crivellari, Anthony Ash, Simona Scalone, Davide Lombardi, Flavio Rizzolio, Antonio Giordano,  and Giuseppe Corona
39809-39822
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Efficacy of epidermal growth factor receptor inhibitors in combination with chemotherapy in advanced non-small cell lung cancer: A meta-analysis of randomized controlled trials

Efficacy of epidermal growth factor receptor inhibitors in combination with chemotherapy in advanced non-small cell lung cancer: A meta-analysis of randomized controlled trials

https://doi.org/10.18632/oncotarget.9503

Minghui Zhang, Hongsheng Guo, Shu Zhao, Yan Wang, Maopeng Yang, Jiawei Yu, Yubo Yan,  and Yan Wang
39823-39833
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

ARF1 promotes prostate tumorigenesis via targeting oncogenic MAPK signaling

ARF1 promotes prostate tumorigenesis via targeting oncogenic MAPK signaling

https://doi.org/10.18632/oncotarget.9405

Jason E. Davis, Xiayang Xie, Jianhui Guo, Wei Huang, Wen-Ming Chu, Shuang Huang, Yong Teng,  and Guangyu Wu
39834-39845
Abstract  |  PDF  |  HTML  |  Order a Reprint

Tumor-tropic endothelial colony forming cells (ECFCs) loaded with near-infrared sensitive Au nanoparticles: A “cellular stove” approach to the photoablation of melanoma

Tumor-tropic endothelial colony forming cells (ECFCs) loaded with near-infrared sensitive Au nanoparticles: A “cellular stove” approach to the photoablation of melanoma

https://doi.org/10.18632/oncotarget.9511

Giancarlo Margheri, Angela Zoppi, Roberto Olmi, Silvana Trigari, Rita Traversi, Mirko Severi, Daniele Bani, Francesca Bianchini, Eugenio Torre, Francesca Margheri, Anastasia Chillà, Alessio Biagioni, Lido Calorini, Anna Laurenzana, Gabriella Fibbi,  and Mario Del Rosso
39846-39860
Abstract  |  PDF  |  HTML  |  Order a Reprint

Inhibition of FGF/FGFR autocrine signaling in mesothelioma with the FGF ligand trap, FP-1039/GSK3052230

Inhibition of FGF/FGFR autocrine signaling in mesothelioma with the FGF ligand trap, FP-1039/GSK3052230

https://doi.org/10.18632/oncotarget.9515

Christina Blackwell, Christian Sherk, Maggie Fricko, Gopinath Ganji, Mary Barnette, Bao Hoang, James Tunstead, Tina Skedzielewski, Hasan Alsaid, Beat M. Jucker, Elisabeth Minthorn, Rakesh Kumar,  and M. Phillip DeYoung
39861-39871
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

FKBP14 overexpression contributes to osteosarcoma carcinogenesis and indicates poor survival outcome

FKBP14 overexpression contributes to osteosarcoma carcinogenesis and indicates poor survival outcome

https://doi.org/10.18632/oncotarget.9524

Zhongming Huang, Junhua Li, Shaohua Du, Yanghua Tang, Ligang Huang, Luwei Xiao,  and Peijian Tong
39872-39884
Abstract  |  PDF  |  HTML  |  Order a Reprint

Microsatellite instability derived JAK1 frameshift mutations are associated with tumor immune evasion in endometrioid endometrial cancer

Microsatellite instability derived JAK1 frameshift mutations are associated with tumor immune evasion in endometrioid endometrial cancer

https://doi.org/10.18632/oncotarget.9414

Ellen Stelloo, Marco A. Versluis, Hans W. Nijman, Marco de Bruyn, Annechien Plat, Elisabeth M. Osse, Reinhardt H. van Dijk, Remi A. Nout, Carien L. Creutzberg, Geertruida H. de Bock, Vincent T. Smit, Tjalling Bosse,  and Harry Hollema
39885-39893
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Activated dendritic cells delivered in tissue compatible biomatrices induce in-situ anti-tumor CTL responses leading to tumor regression

Activated dendritic cells delivered in tissue compatible biomatrices induce in-situ anti-tumor CTL responses leading to tumor regression

https://doi.org/10.18632/oncotarget.9529

Vivek Verma, Young Kim, Min-Cheol Lee, Jae-Tae Lee, Sunghoon Cho, In-Kyu Park, Jung Joon Min, Je Jung Lee, Shee Eun Lee,  and Joon Haeng Rhee
39894-39906
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MicroRNA-613 inhibits cell growth, migration and invasion of papillary thyroid carcinoma by regulating SphK2

MicroRNA-613 inhibits cell growth, migration and invasion of papillary thyroid carcinoma by regulating SphK2

https://doi.org/10.18632/oncotarget.9530

Wangwang Qiu, Zhili Yang, Youben Fan,  and Qi Zheng
39907-39915
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Tumor-infiltrating immune cell subpopulations influence the oncologic outcome after intravesical Bacillus Calmette-Guérin therapy in bladder cancer

Tumor-infiltrating immune cell subpopulations influence the oncologic outcome after intravesical Bacillus Calmette-Guérin therapy in bladder cancer

https://doi.org/10.18632/oncotarget.9537

Renate Pichler, Josef Fritz, Claudia Zavadil, Georg Schäfer, Zoran Culig,  and Andrea Brunner
39916-39930
Abstract  |  PDF  |  HTML  |  Order a Reprint

Screen-identified selective inhibitor of lysine demethylase 5A blocks cancer cell growth and drug resistance

Screen-identified selective inhibitor of lysine demethylase 5A blocks cancer cell growth and drug resistance

https://doi.org/10.18632/oncotarget.9539

Molly Gale, Joyce Sayegh, Jian Cao, Michael Norcia, Peter Gareiss, Denton Hoyer, Jane S. Merkel,  and Qin Yan
39931-39944
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Prognostic value of preoperative serum lactate dehydrogenase levels for resectable gastric cancer and prognostic nomograms

Prognostic value of preoperative serum lactate dehydrogenase levels for resectable gastric cancer and prognostic nomograms

https://doi.org/10.18632/oncotarget.9459

Zi-Xian Wang, Lu-Ping Yang, Miao-Zhen Qiu, Zhi-Qiang Wang, Yi-Xin Zhou, Feng Wang, Dong-Sheng Zhang, Feng-Hua Wang, Yu-Hong Li,  and Rui-Hua Xu
39945-39956
Abstract  |  PDF  |  HTML  |  Order a Reprint

Expression of the receptor for hyaluronic acid mediated motility (RHAMM) is associated with poor prognosis and metastasis in non-small cell lung carcinoma

Expression of the receptor for hyaluronic acid mediated motility (RHAMM) is associated with poor prognosis and metastasis in non-small cell lung carcinoma

https://doi.org/10.18632/oncotarget.9554

Dunrui Wang, Navneet Narula, Stephanie Azzopardi, Roger S. Smith, Abu Nasar, Nasser K. Altorki, Vivek Mittal, Romel Somwar, Brendon M. Stiles,  and Yi-Chieh Nancy Du
39957-39969
Abstract  |  PDF  |  HTML  |  Order a Reprint

SCD1 is associated with tumor promotion, late stage and poor survival in lung adenocarcinoma

SCD1 is associated with tumor promotion, late stage and poor survival in lung adenocarcinoma

https://doi.org/10.18632/oncotarget.9461

Jun Huang, Xing-Xing Fan, Jiaxi He, Hui Pan, Run-Ze Li, Liyan Huang, Zebo Jiang, Xiao-Jun Yao, Liang Liu, Elaine Lai-Han Leung,  and Jian-Xing He
39970-39979
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Suppression of progranulin expression inhibits bladder cancer growth and sensitizes cancer cells to cisplatin

Suppression of progranulin expression inhibits bladder cancer growth and sensitizes cancer cells to cisplatin

https://doi.org/10.18632/oncotarget.9556

Simone Buraschi, Shi-Qiong Xu, Manuela Stefanello, Igor Moskalev, Alaide Morcavallo, Marco Genua, Ryuta Tanimoto, Ruth Birbe, Stephen C. Peiper, Leonard G. Gomella, Antonino Belfiore, Peter C. Black, Renato V. Iozzo,  and Andrea Morrione
39980-39995
Abstract  |  PDF  |  HTML  |  Order a Reprint

Identification of FRA-1 as a novel player in pancreatic cancer in cooperation with a MUC1: ERK signaling axis

Identification of FRA-1 as a novel player in pancreatic cancer in cooperation with a MUC1: ERK signaling axis

https://doi.org/10.18632/oncotarget.9557

Ryan L. Hanson, Roger B. Brown, Maria M. Steele, Paul M. Grandgenett, James A. Grunkemeyer,  and Michael A. Hollingsworth
39996-40011
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Differential association for N-acetyltransferase 2 genotype and phenotype with bladder cancer risk in Chinese population

Differential association for N-acetyltransferase 2 genotype and phenotype with bladder cancer risk in Chinese population

https://doi.org/10.18632/oncotarget.9475

Lei Quan, Koushik Chattopadhyay, Heather H. Nelson, Kenneth K. Chan, Yong-Bing Xiang, Wei Zhang, Renwei Wang, Yu-Tang Gao,  and Jian-Min Yuan
40012-40024
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Higher methylation intensity induced by EBV LMP1 via NF-κB/DNMT3b signaling contributes to silencing of PTEN gene

Higher methylation intensity induced by EBV LMP1 via NF-κB/DNMT3b signaling contributes to silencing of PTEN gene

https://doi.org/10.18632/oncotarget.9474

Hong Peng, Yuxiang Chen, Pinggui Gong, Longmei Cai, Xiaoming Lyu, Qiang Jiang, Jianguo Wang, Juan Lu, Kaitai Yao, Kunping Liu, Jinbang Li,  and Xin Li
40025-40037
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MicroRNA-138 acts as a tumor suppressor in non small cell lung cancer via targeting YAP1

MicroRNA-138 acts as a tumor suppressor in non small cell lung cancer via targeting YAP1

https://doi.org/10.18632/oncotarget.9480

Ling Xiao, Hui Zhou, Xiang-Ping Li, Juan Chen, Chao Fang, Chen-Xue Mao, Jia-Jia Cui, Wei Zhang, Hong-Hao Zhou, Ji-Ye Yin,  and Zhao-Qian Liu
40038-40046
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A transferrin-target magnetic/fluorescent dual-mode probe significantly enhances the diagnosis of non-small cell lung cancer

A transferrin-target magnetic/fluorescent dual-mode probe significantly enhances the diagnosis of non-small cell lung cancer

https://doi.org/10.18632/oncotarget.9482

Jiali Cai, Bingxin Gu, Fengwen Cao,  and Shiyuan Liu
40047-40059
Abstract  |  PDF  |  HTML  |  Order a Reprint

Activin B promotes endometrial cancer cell migration by down-regulating E-cadherin via SMAD-independent MEK-ERK1/2-SNAIL signaling

Activin B promotes endometrial cancer cell migration by down-regulating E-cadherin via SMAD-independent MEK-ERK1/2-SNAIL signaling

https://doi.org/10.18632/oncotarget.9483

Siyuan Xiong, Christian Klausen, Jung-Chien Cheng,  and Peter C.K. Leung
40060-40072
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Everolimus induces Met inactivation by disrupting the FKBP12/Met complex

Everolimus induces Met inactivation by disrupting the FKBP12/Met complex

https://doi.org/10.18632/oncotarget.9484

Lucia Raimondo, Valentina D’Amato, Alberto Servetto, Roberta Rosa, Roberta Marciano, Luigi Formisano, Concetta Di Mauro, Roberta Clara Orsini, Priscilla Cascetta, Paola Ciciola, Ana Paula De Maio, Maria Flavia Di Renzo, Sandro Cosconati, Agostino Bruno, Antonio Randazzo, Filomena Napolitano, Nunzia Montuori, Bianca Maria Veneziani, Sabino De Placido,  and Roberto Bianco
40073-40084
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Predictors of long-term response to abiraterone in patients with metastastic castration-resistant prostate cancer: a retrospective cohort study

Predictors of long-term response to abiraterone in patients with metastastic castration-resistant prostate cancer: a retrospective cohort study

https://doi.org/10.18632/oncotarget.9485

Elena Verzoni, Ugo De Giorgi, Lisa Derosa, Orazio Caffo, Francesco Boccardo, Gaetano Facchini, Luca Porcu, Fabio De Vincenzo, Alberto Zaniboni, Vincenzo Emanuele Chiuri, Lucia Fratino, Daniele Santini, Vincenzo Adamo, Rocco De Vivo, Angelo Dinota, Caterina Messina, Riccardo Ricotta, Claudia Caserta, Claudio Scavelli, Marina Susi, Alfredo Tartarone, Giuseppe Surace, Alessandra Mosca, Michele Bruno, Sandro Barni, Paolo Grassi,  and Giuseppe Procopio
40085-40094
Abstract  |  PDF  |  HTML  |  Order a Reprint

Tailored multimodality therapy guided by a two-step decision making process for head-and-neck cancer of unknown primary

Tailored multimodality therapy guided by a two-step decision making process for head-and-neck cancer of unknown primary

https://doi.org/10.18632/oncotarget.9492

Shengjin Dou, Wei Qian, Qinghai Ji, Zhuoying Wang,  and Guopei Zhu
40095-40105
Abstract  |  PDF  |  HTML  |  Order a Reprint

Soluble Toll-like receptor 4 is a potential serum biomarker in non-small cell lung cancer

Soluble Toll-like receptor 4 is a potential serum biomarker in non-small cell lung cancer

https://doi.org/10.18632/oncotarget.9496

Feng Wei, Fan Yang, Jing Li, Yu Zheng, Wenwen Yu, Lili Yang,  and Xiubao Ren
40106-40114
Abstract  |  PDF  |  HTML  |  Order a Reprint

Pre-clinical efficacy and synergistic potential of the MDM2-p53 antagonists, Nutlin-3 and RG7388, as single agents and in combined treatment with cisplatin in ovarian cancer

Pre-clinical efficacy and synergistic potential of the MDM2-p53 antagonists, Nutlin-3 and RG7388, as single agents and in combined treatment with cisplatin in ovarian cancer

https://doi.org/10.18632/oncotarget.9499

Maryam Zanjirband, Richard J. Edmondson,  and John Lunec
40115-40134
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Variants in human papillomavirus receptor and associated genes are associated with type-specific HPV infection and lesion progression of the cervix

Variants in human papillomavirus receptor and associated genes are associated with type-specific HPV infection and lesion progression of the cervix

https://doi.org/10.18632/oncotarget.9510

Jian Zou, Zhu Cao, Jianyang Zhang, Tingting Chen, Shizhou Yang, Yongjie Huang, Die Hong, Yang Li, Xiaojing Chen, Xinyu Wang, Xiaodong Cheng, Weiguo Lu,  and Xing Xie
40135-40147
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Periostin promotes tumor angiogenesis in pancreatic cancer via Erk/VEGF signaling

Periostin promotes tumor angiogenesis in pancreatic cancer via Erk/VEGF signaling

https://doi.org/10.18632/oncotarget.9512

Yang Liu, Fan Li, Feng Gao, Lingxi Xing, Peng Qin, Xingxin Liang, Jiajie Zhang, Xiaohui Qiao, Lizhou Lin, Qian Zhao,  and Lianfang Du
40148-40159
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Tspan5 is an independent favourable prognostic factor and suppresses tumour growth in gastric cancer

Tspan5 is an independent favourable prognostic factor and suppresses tumour growth in gastric cancer

https://doi.org/10.18632/oncotarget.9514

Peirong He, Suihai Wang, Xuefeng Zhang, Yanjun Gao, Wenbo Niu, Ningning Dong, Xiangyi Shi, Yan Geng, Qiang Ma, Ming Li, Bo Jiang,  and Ji-Liang Li
40160-40173
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

BKCa promotes growth and metastasis of prostate cancer through facilitating the coupling between αvβ3 integrin and FAK

BKCa promotes growth and metastasis of prostate cancer through facilitating the coupling between αvβ3 integrin and FAK

https://doi.org/10.18632/oncotarget.9559

Cheng Du, Zhendong Zheng, Danqi Li, Li Chen, Na Li, Xiaomin Yi, Yang Yang, Fang Guo, Wenchao Liu, Xiaodong Xie,  and Manjiang Xie
40174-40188
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Fibronectin on circulating extracellular vesicles as a liquid biopsy to detect breast cancer

Fibronectin on circulating extracellular vesicles as a liquid biopsy to detect breast cancer

https://doi.org/10.18632/oncotarget.9561

Pyong-Gon Moon, Jeong-Eun Lee, Young-Eun Cho, Soo Jung Lee, Yee Soo Chae, Jin Hyang Jung, In-San Kim, Ho Yong Park,  and Moon-Chang Baek
40189-40199
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Big data and computational biology strategy for personalized prognosis

Big data and computational biology strategy for personalized prognosis

https://doi.org/10.18632/oncotarget.9571

Ghim Siong Ow, Zhiqun Tang,  and Vladimir A. Kuznetsov
40200-40220
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Evaluating L1CAM expression in human endometrial cancer using qRT-PCR

Evaluating L1CAM expression in human endometrial cancer using qRT-PCR

https://doi.org/10.18632/oncotarget.9574

Sara Notaro, Daniel Reimer, Michaela Duggan-Peer, Heidi Fiegl, Annamarie Wiedermair, Julia Rössler, Peter Altevogt, Christian Marth,  and Alain Gustave Zeimet
40221-40232
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Indolin-2-one compounds targeting thioredoxin reductase as potential anticancer drug leads

Indolin-2-one compounds targeting thioredoxin reductase as potential anticancer drug leads

https://doi.org/10.18632/oncotarget.9579

Kamila K. Kaminska, Helene C. Bertrand, Hisashi Tajima, William C. Stafford, Qing Cheng, Wan Chen, Geoffrey Wells, Elias S.J. Arner,  and Eng-Hui Chew
40233-40251
Abstract  |  PDF  |  HTML  |  Order a Reprint

Rab25 acts as an oncogene in luminal B breast cancer and is causally associated with Snail driven EMT

Rab25 acts as an oncogene in luminal B breast cancer and is causally associated with Snail driven EMT

https://doi.org/10.18632/oncotarget.9730

Shreya Mitra, Lorenzo Federico, Wei Zhao, Jennifer Dennison, Tapasree Roy Sarkar, Fan Zhang, Vinita Takiar, Kwai W. Cheng, Sendurai Mani, Ju Seog Lee,  and Gordon B. Mills
40252-40265
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

JARID2 promotes invasion and metastasis of hepatocellular carcinoma by facilitating epithelial-mesenchymal transition through PTEN/AKT signaling

JARID2 promotes invasion and metastasis of hepatocellular carcinoma by facilitating epithelial-mesenchymal transition through PTEN/AKT signaling

https://doi.org/10.18632/oncotarget.9733

Xiong Lei, Jiang-Feng Xu, Rui-Min Chang, Feng Fang, Chao-Hui Zuo,  and Lian-Yue Yang
40266-40284
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Isoliensinine induces dephosphorylation of NF-kB p65 subunit at Ser536 via a PP2A-dependent mechanism in hepatocellular carcinoma cells: roles of impairing PP2A/I2PP2A interaction

Isoliensinine induces dephosphorylation of NF-kB p65 subunit at Ser536 via a PP2A-dependent mechanism in hepatocellular carcinoma cells: roles of impairing PP2A/I2PP2A interaction

https://doi.org/10.18632/oncotarget.9603

Guangwen Shu, Lang Zhang, Shanqing Jiang, Zhuo Cheng, Guan Wang, Xu Huang,  and Xinzhou Yang
40285-40296
Abstract  |  PDF  |  HTML  |  Order a Reprint

MtDNA depleted PC3 cells exhibit Warburg effect and cancer stem cell features

MtDNA depleted PC3 cells exhibit Warburg effect and cancer stem cell features

https://doi.org/10.18632/oncotarget.9610

Xiaoran Li, Yali Zhong, Jie Lu, Karol Axcrona, Lars Eide, Randi G. Syljuåsen, Qian Peng, Junbai Wang, Hongquan Zhang, Mariusz Adam Goscinski, Gunnar Kvalheim, Jahn M. Nesland,  and Zhenhe Suo
40297-40313
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

miRNA-337-3p inhibits gastric cancer progression through repressing myeloid zinc finger 1-facilitated expression of matrix metalloproteinase 14

miRNA-337-3p inhibits gastric cancer progression through repressing myeloid zinc finger 1-facilitated expression of matrix metalloproteinase 14

https://doi.org/10.18632/oncotarget.9739

Liduan Zheng, Wanju Jiao, Hong Mei, Huajie Song, Dan Li, Xuan Xiang, Yajun Chen, Feng Yang, Huanhuan Li, Kai Huang,  and Qiangsong Tong
40314-40328
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Targeting FOSB with a cationic antimicrobial peptide, TP4, for treatment of triple-negative breast cancer

Targeting FOSB with a cationic antimicrobial peptide, TP4, for treatment of triple-negative breast cancer

https://doi.org/10.18632/oncotarget.9612

Chen-Hung Ting, Yi-Chun Chen, Chang-Jer Wu,  and Jyh-Yih Chen
40329-40347
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Reprofiling using a zebrafish melanoma model reveals drugs cooperating with targeted therapeutics

Reprofiling using a zebrafish melanoma model reveals drugs cooperating with targeted therapeutics

https://doi.org/10.18632/oncotarget.9613

Laura Fernandez del Ama, Mary Jones, Paul Walker, Anna Chapman, Julia A. Braun, Jasmine Mohr,  and Adam F. L. Hurlstone
40348-40361
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Cdc6 contributes to cisplatin-resistance by activation of ATR-Chk1 pathway in bladder cancer cells

Cdc6 contributes to cisplatin-resistance by activation of ATR-Chk1 pathway in bladder cancer cells

https://doi.org/10.18632/oncotarget.9616

Sansan Chen, Xinglu Chen, Gui’e Xie, Yue He, Daoyu Yan, Dianpeng Zheng, Shi Li, Xinyang Fu, Yeping Li, Xiang Pang, Zhiming Hu, Hongwei Li, Wanlong Tan,  and Jinlong Li
40362-40376
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Upregulation of SIRT6 predicts poor prognosis and promotes metastasis of non-small cell lung cancer via the ERK1/2/MMP9 pathway

Upregulation of SIRT6 predicts poor prognosis and promotes metastasis of non-small cell lung cancer via the ERK1/2/MMP9 pathway

https://doi.org/10.18632/oncotarget.9750

Lihong Bai, Gengpeng Lin, Longhua Sun, Yangli Liu, Xinyan Huang, Chuangjie Cao, Yubiao Guo,  and Canmao Xie
40377-40386
Abstract  |  PDF  |  HTML  |  Order a Reprint

Integrin alphavbeta3 enhances β-catenin signaling in acute myeloid leukemia harboring Fms-like tyrosine kinase-3 internal tandem duplication mutations: implications for microenvironment influence on sorafenib sensitivity

Integrin alphavbeta3 enhances β-catenin signaling in acute myeloid leukemia harboring Fms-like tyrosine kinase-3 internal tandem duplication mutations: implications for microenvironment influence on sorafenib sensitivity

https://doi.org/10.18632/oncotarget.9617

Hai Yi, Dongfeng Zeng, Zhaohua Shen, Jun Liao, Xiaoguo Wang, Yao Liu, Xi Zhang,  and Peiyan Kong
40387-40397
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Multi-kinase inhibitors interact with sildenafil and ERBB1/2/4 inhibitors to kill tumor cells in vitro and in vivo

Multi-kinase inhibitors interact with sildenafil and ERBB1/2/4 inhibitors to kill tumor cells in vitro and in vivo

https://doi.org/10.18632/oncotarget.9752

Laurence Booth, Thomas Albers, Jane L. Roberts, Mehrad Tavallai, Andrew Poklepovic, Iryna O. Lebedyeva,  and Paul Dent
40398-40417
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Functional and prognostic significance of long non-coding RNA MALAT1 as a metastasis driver in ER negative lymph node negative breast cancer

Functional and prognostic significance of long non-coding RNA MALAT1 as a metastasis driver in ER negative lymph node negative breast cancer

https://doi.org/10.18632/oncotarget.9622

Mahdieh Jadaliha, Xinying Zong, Pushkar Malakar, Tania Ray, Deepak K. Singh, Susan M. Freier, Tor Jensen, Supriya G. Prasanth, Rotem Karni, Partha S. Ray,  and Kannanganattu V. Prasanth
40418-40436
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A novel peptide targeting Clec9a on dendritic cell for cancer immunotherapy

A novel peptide targeting Clec9a on dendritic cell for cancer immunotherapy

https://doi.org/10.18632/oncotarget.9624

Zhongyi Yan, Yahong Wu, Jiangfeng Du, Guodong Li, Shengdian Wang, Wenpeng Cao, Xiuman Zhou, Chunjing Wu, Dan Zhang, Xueli Jing, Yifan Li, Hongfei Wang, Yanfeng Gao,  and Yuanming Qi
40437-40450
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Inverse role of distinct subsets and distribution of macrophage in lung cancer prognosis: a meta-analysis

Inverse role of distinct subsets and distribution of macrophage in lung cancer prognosis: a meta-analysis

https://doi.org/10.18632/oncotarget.9625

Pin Wu, Dang Wu, Lufeng Zhao, Lijian Huang, Gang Chen, Gang Shen, Jian Huang,  and Ying Chai
40451-40460
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Transcriptomic and proteomic analysis of mouse radiation-induced acute myeloid leukaemia (AML)

Transcriptomic and proteomic analysis of mouse radiation-induced acute myeloid leukaemia (AML)

https://doi.org/10.18632/oncotarget.9626

Christophe Badie, Agnieszka Blachowicz, Zarko Barjaktarovic, Rosemary Finnon, Arlette Michaux, Hakan Sarioglu, Natalie Brown, Grainne Manning, M. Abderrafi Benotmane, Soile Tapio, Joanna Polanska,  and Simon D. Bouffler
40461-40480
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Noninvasive detection of tumor-associated mutations from circulating cell-free DNA in hepatocellular carcinoma patients by targeted deep sequencing

Noninvasive detection of tumor-associated mutations from circulating cell-free DNA in hepatocellular carcinoma patients by targeted deep sequencing

https://doi.org/10.18632/oncotarget.9629

Wenjun Liao, Huayu Yang, Haifeng Xu, Yanan Wang, Penglei Ge, Jinjun Ren, Wei Xu, Xin Lu, Xinting Sang, Shouxian Zhong, Hongbing Zhang,  and Yilei Mao
40481-40490
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Differences in somatic mutation landscape of hepatocellular carcinoma in Asian American and European American populations

Differences in somatic mutation landscape of hepatocellular carcinoma in Asian American and European American populations

https://doi.org/10.18632/oncotarget.9636

Song Yao, Christopher Johnson, Qiang Hu, Li Yan, Biao Liu, Christine B. Ambrosone, Jianmin Wang,  and Song Liu
40491-40499
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Genetic polymorphisms in TNIP1 increase the risk of gastric carcinoma

Genetic polymorphisms in TNIP1 increase the risk of gastric carcinoma

https://doi.org/10.18632/oncotarget.9637

Zhao Liu, Yuting Shi, Yuyan Na, Qi Zhang, Sizhe Cao, Xianglong Duan, Xiyang Zhang, Hua Yang, Tianbo Jin,  and Yiming Li
40500-40507
Abstract  |  PDF  |  HTML  |  Order a Reprint

TREM-1low is a novel characteristic for tumor-associated macrophages in lung cancer

TREM-1low is a novel characteristic for tumor-associated macrophages in lung cancer

https://doi.org/10.18632/oncotarget.9639

Guangbo Zhang, Hongmei Liu, Jian Huang, Siwen Chen, Xudong Pan, Haitao Huang,  and Ling Wang
40508-40517
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A new antiproliferative noscapine analogue: chemical synthesis and biological evaluation

A new antiproliferative noscapine analogue: chemical synthesis and biological evaluation

https://doi.org/10.18632/oncotarget.9642

Peter E. Ghaly, Rabab M. Abou El-Magd, Cassandra D.M. Churchill, Jack A. Tuszynski,  and F. G. West
40518-40530
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Hypoxia potentiates the cytotoxic effect of piperlongumine in pheochromocytoma models

Hypoxia potentiates the cytotoxic effect of piperlongumine in pheochromocytoma models

https://doi.org/10.18632/oncotarget.9643

Petra Bullova, Antony Cougnoux, Luma Abunimer, Juraj Kopacek, Silvia Pastorekova,  and Karel Pacak
40531-40545
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Mesenchymal stem cell-like properties of CD133+ glioblastoma initiating cells

Mesenchymal stem cell-like properties of CD133+ glioblastoma initiating cells

https://doi.org/10.18632/oncotarget.9658

Lorena Favaro Pavon, Tatiana Tais Sibov, Daniela Mara de Oliveira, Luciana C. Marti, Francisco Romero Cabral, Jean Gabriel de Souza, Pamela Boufleur, Suzana M.F. Malheiros, Manuel A. de Paiva Neto, Edgard Ferreira da Cruz, Ana Marisa Chudzinski-Tavassi,  and Sérgio Cavalheiro
40546-40557
Abstract  |  PDF  |  HTML  |  Order a Reprint

Phenotypic alteration of CD8+ T cells in chronic lymphocytic leukemia is associated with epigenetic reprogramming

Phenotypic alteration of CD8+ T cells in chronic lymphocytic leukemia is associated with epigenetic reprogramming

https://doi.org/10.18632/oncotarget.9941

Jiazhu Wu, Xiaojing Xu, Eun-Joon Lee, Austin Y. Shull, Lirong Pei, Farrukh Awan, Xiaoling Wang, Jeong-Hyeon Choi, Libin Deng, Hong-Bo Xin, Wenxun Zhong, Jinhua Liang, Yi Miao, Yujie Wu, Lei Fan, Jianyong Li, Wei Xu,  and Huidong Shi
40558-40570
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Extracellular matrix-specific Caveolin-1 phosphorylation on tyrosine 14 is linked to augmented melanoma metastasis but not tumorigenesis

Extracellular matrix-specific Caveolin-1 phosphorylation on tyrosine 14 is linked to augmented melanoma metastasis but not tumorigenesis

https://doi.org/10.18632/oncotarget.9738

Rina Ortiz, Jorge Díaz, Natalia Díaz, Lorena Lobos-Gonzalez, Areli Cárdenas, Pamela Contreras, María Inés Díaz, Ellen Otte, Justin Cooper-White, Vicente Torres, Lisette Leyton,  and Andrew F.G. Quest
40571-40593
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Interaction of DNA demethylase and histone methyltransferase upregulates Nrf2 in 5-fluorouracil-resistant colon cancer cells

Interaction of DNA demethylase and histone methyltransferase upregulates Nrf2 in 5-fluorouracil-resistant colon cancer cells

https://doi.org/10.18632/oncotarget.9745

Kyoung Ah Kang, Mei Jing Piao, Yea Seong Ryu, Hee Kyoung Kang, Weon Young Chang, Young Sam Keum,  and Jin Won Hyun
40594-40620
Abstract  |  PDF  |  HTML  |  Order a Reprint

Lactic acidosis switches cancer cells from aerobic glycolysis back to dominant oxidative phosphorylation

Lactic acidosis switches cancer cells from aerobic glycolysis back to dominant oxidative phosphorylation

https://doi.org/10.18632/oncotarget.9746

Hao Wu, Minfeng Ying,  and Xun Hu
40621-40629
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Tetraspanin-8 promotes hepatocellular carcinoma metastasis by increasing ADAM12m expression

Tetraspanin-8 promotes hepatocellular carcinoma metastasis by increasing ADAM12m expression

https://doi.org/10.18632/oncotarget.9769

Tingting Fang, Jiajia Lin, Yanru Wang, Guangnan Chen, Jing Huang, Jie Chen, Yan Zhao, Ruixia Sun, Chunmin Liang,  and Binbin Liu
40630-40643
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MicroRNA-375 suppresses human colorectal cancer metastasis by targeting Frizzled 8

MicroRNA-375 suppresses human colorectal cancer metastasis by targeting Frizzled 8

https://doi.org/10.18632/oncotarget.9811

Lingling Xu, Tao Wen, Zhe Liu, Feng Xu, Lei Yang, Jian Liu, Guosheng Feng,  and Guangyu An
40644-40656
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

microRNA-558 facilitates the expression of hypoxia-inducible factor 2 alpha through binding to 5′-untranslated region in neuroblastoma

microRNA-558 facilitates the expression of hypoxia-inducible factor 2 alpha through binding to 5′-untranslated region in neuroblastoma

https://doi.org/10.18632/oncotarget.9813

Hongxia Qu, Liduan Zheng, Huajie Song, Wanju Jiao, Dan Li, Erhu Fang, Xiaojing Wang, Hong Mei, Jiarui Pu, Kai Huang,  and Qiangsong Tong
40657-40673
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Upregulation of glycolysis and oxidative phosphorylation in benzo[α]pyrene and arsenic-induced rat lung epithelial transformed cells

Upregulation of glycolysis and oxidative phosphorylation in benzo[α]pyrene and arsenic-induced rat lung epithelial transformed cells

https://doi.org/10.18632/oncotarget.9814

Huachen Chen, Lai-Sheung Lee, Guanwu Li, Sai-Wah Tsao,  and Jen-Fu Chiu
40674-40689
Abstract  |  PDF  |  HTML  |  Order a Reprint

Cellular androgen content influences enzalutamide agonism of F877L mutant androgen receptor

Cellular androgen content influences enzalutamide agonism of F877L mutant androgen receptor

https://doi.org/10.18632/oncotarget.9816

Daniel J. Coleman, Kathryn Van Hook, Carly J. King, Jacob Schwartzman, Robert Lisac, Joshua Urrutia, Archana Sehrawat, Josha Woodward, Nicholas J. Wang, Roman Gulati, George V. Thomas, Tomasz M. Beer, Martin Gleave, James E. Korkola, Lina Gao, Laura M. Heiser,  and Joshi J. Alumkal
40690-40703
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Reduced CD146 expression promotes tumorigenesis and cancer stemness in colorectal cancer through activating Wnt/β-catenin signaling

Reduced CD146 expression promotes tumorigenesis and cancer stemness in colorectal cancer through activating Wnt/β-catenin signaling

https://doi.org/10.18632/oncotarget.9930

Dan Liu, Lei Du, Dong Chen, Zhongde Ye, Hongxia Duan, Tao Tu, Jing Feng, Yili Yang, Quan Chen,  and Xiyun Yan
40704-40718
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Clinical Research Papers

Multicentric survey on dose reduction/interruption of cancer drug therapy in 12.472 patients: indicators of suspected adverse reactions

Multicentric survey on dose reduction/interruption of cancer drug therapy in 12.472 patients: indicators of suspected adverse reactions

https://doi.org/10.18632/oncotarget.8942

Andrea Casadei Gardini, Elena Tenti, Carla Masini, Oriana Nanni, Emanuela Scarpi, Martina Valgiusti, Silvia Restuccia, Maria Laura Gallani, Simonetta Palazzini, Erica Bianchini, Silvia Menozzi, Antonio Maugeri, Dino Amadori, Martina Minguzzi,  and Giovanni Luca Frassineti
40719-40724
Abstract  |  PDF  |  HTML  |  Order a Reprint

High temperature requirement A3 (HTRA3) expression predicts postoperative recurrence and survival in patients with non-small-cell lung cancer

High temperature requirement A3 (HTRA3) expression predicts postoperative recurrence and survival in patients with non-small-cell lung cancer

https://doi.org/10.18632/oncotarget.9173

Jingya Zhao, Jing Zhang, Xin Zhang, Mingxiang Feng,  and Jieming Qu
40725-40734
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Clinicopathological features and prognosis of colonic gastrointestinal stromal tumors: evaluation of a pooled case series

Clinicopathological features and prognosis of colonic gastrointestinal stromal tumors: evaluation of a pooled case series

https://doi.org/10.18632/oncotarget.9196

Fan Feng, Yangzi Tian, Zhen Liu, Guanghui Xu, Shushang Liu, Man Guo, Xiao Lian, Daiming Fan,  and Hongwei Zhang
40735-40745
Abstract  |  PDF  |  HTML  |  Order a Reprint

Radiobiological modeling of two stereotactic body radiotherapy schedules in patients with stage I peripheral non-small cell lung cancer

Radiobiological modeling of two stereotactic body radiotherapy schedules in patients with stage I peripheral non-small cell lung cancer

https://doi.org/10.18632/oncotarget.9442

Bao-tian Huang, Zhu Lin, Pei-xian Lin, Jia-yang Lu,  and Chuang-zhen Chen
40746-40755
Abstract  |  PDF  |  HTML  |  Order a Reprint

Phase I dose-escalation study of helical intensity-modulated radiotherapy-based stereotactic body radiotherapy for hepatocellular carcinoma

Phase I dose-escalation study of helical intensity-modulated radiotherapy-based stereotactic body radiotherapy for hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.9450

Jun Won Kim, Jinsil Seong, Ik Jae Lee, Joong Yeol Woo,  and Kwang-Hyub Han
40756-40766
Abstract  |  PDF  |  HTML  |  Order a Reprint

Reviews

Repurposing metformin for cancer treatment: current clinical studies

Repurposing metformin for cancer treatment: current clinical studies

https://doi.org/10.18632/oncotarget.8194

Young Kwang Chae, Ayush Arya, Mary-Kate Malecek, Daniel Sanghoon Shin, Benedito Carneiro, Sunandana Chandra, Jason Kaplan, Aparna Kalyan, Jessica K. Altman, Leonidas Platanias,  and Francis Giles
40767-40780
Abstract  |  PDF  |  HTML  |  Order a Reprint

Addressing the elephant in the room, therapeutic resistance in non-small cell lung cancer, with epigenetic therapies

Addressing the elephant in the room, therapeutic resistance in non-small cell lung cancer, with epigenetic therapies

https://doi.org/10.18632/oncotarget.8205

Corey A. Carter, Karen Zeman, Regina M. Day, Patrick Richard, Arnold Oronsky, Neil Oronsky, Michelle Lybeck, Jan Scicinski,  and Bryan Oronsky
40781-40791
Abstract  |  PDF  |  HTML  |  Order a Reprint

Tall cell variant of papillary thyroid carcinoma: current evidence on clinicopathologic features and molecular biology

Tall cell variant of papillary thyroid carcinoma: current evidence on clinicopathologic features and molecular biology

https://doi.org/10.18632/oncotarget.8215

Xiaofei Wang, Wenli Cheng, Chongqing Liu,  and Jingdong Li
40792-40799
Abstract  |  PDF  |  HTML  |  Order a Reprint

Tetrandrine, a Chinese plant-derived alkaloid, is a potential candidate for cancer chemotherapy

Tetrandrine, a Chinese plant-derived alkaloid, is a potential candidate for cancer chemotherapy

https://doi.org/10.18632/oncotarget.8315

Ting Liu, Xin Liu,  and Wenhua Li
40800-40815
Abstract  |  PDF  |  HTML  |  Order a Reprint

Multidisciplinary management of hepatocellular carcinoma with portal vein tumor thrombus – Eastern Hepatobiliary Surgical Hospital consensus statement

Multidisciplinary management of hepatocellular carcinoma with portal vein tumor thrombus – Eastern Hepatobiliary Surgical Hospital consensus statement

https://doi.org/10.18632/oncotarget.8386

Shuqun Cheng, Jiamei Yang, Feng Shen, Weiping Zhou, Yi Wang, Wenming Cong, Guang shun Yang, Hongyan Cheng, Heping Hu, Chunfang Gao, Jia Guo, Aijun Li, Yan Meng, Xiaoqing Jiang, Yefa Yang, Guojun Qian, Ming Luo, Bing Hu, Xiaobo Man, Baohua Zhang, Changqing Su, Feiguo Zhou, Nan Li, Jie Shi, Meng Wang, Yaxin Zheng, Weixing Guo, Juxian Sun, Hongyang Wang, Wan-yee Lau,  and Meng-chao Wu
40816-40829
Abstract  |  PDF  |  HTML  |  Order a Reprint

Adipogenic miRNA and meta-signature miRNAs involved in human adipocyte differentiation and obesity

Adipogenic miRNA and meta-signature miRNAs involved in human adipocyte differentiation and obesity

https://doi.org/10.18632/oncotarget.8518

Chunmei Shi, Fangyan Huang, Xiaohong Gu, Min Zhang, Juan Wen, Xing Wang, Lianghui You, Xianwei Cui, Chenbo Ji,  and Xirong Guo
40830-40845
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The emerging roles and therapeutic potential of cyclin-dependent kinase 11 (CDK11) in human cancer

The emerging roles and therapeutic potential of cyclin-dependent kinase 11 (CDK11) in human cancer

https://doi.org/10.18632/oncotarget.8519

Yubing Zhou, Jacson K. Shen, Francis J. Hornicek, Quancheng Kan,  and Zhenfeng Duan
40846-40859
Abstract  |  PDF  |  HTML  |  Order a Reprint

Neuraminidase-1: A novel therapeutic target in multistage tumorigenesis

Neuraminidase-1: A novel therapeutic target in multistage tumorigenesis

https://doi.org/10.18632/oncotarget.8396

Fiona Haxho, Ronald J. Neufeld,  and Myron R. Szewczuk
40860-40881
Abstract  |  PDF  |  HTML  |  Order a Reprint

Engineered nanoparticles induce cell apoptosis: potential for cancer therapy

Engineered nanoparticles induce cell apoptosis: potential for cancer therapy

https://doi.org/10.18632/oncotarget.8553

Dan-Dan Ma,  and Wan-Xi Yang
40882-40903
Abstract  |  PDF  |  HTML  |  Order a Reprint


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