Oncotarget

Vol 7, No 23

June 7, 2016

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Treatment with L-asparaginase (Asp) inhibits proliferation and induces apoptosis across different glioblastoma cells. See Karpel-Massler et al.

Table of Contents

Priority Research Papers

LTR12 promoter activation in a broad range of human tumor cells by HDAC inhibition

LTR12 promoter activation in a broad range of human tumor cells by HDAC inhibition

https://doi.org/10.18632/oncotarget.9255

Sonja K. Krönung, Ulrike Beyer, Maria Luisa Chiaramonte, Diletta Dolfini, Roberto Mantovani,  and Matthias Dobbelstein
33484-33497
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Enhanced killing of chordoma cells by antibody-dependent cell-mediated cytotoxicity employing the novel anti-PD-L1 antibody avelumab

Enhanced killing of chordoma cells by antibody-dependent cell-mediated cytotoxicity employing the novel anti-PD-L1 antibody avelumab

https://doi.org/10.18632/oncotarget.9256

Rika Fujii, Eitan R. Friedman, Jacob Richards, Kwong Y. Tsang, Christopher R. Heery, Jeffrey Schlom,  and James W. Hodge
33498-33511
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Metabolic reprogramming of glioblastoma cells by L-asparaginase sensitizes for apoptosis in vitro and in vivo

Metabolic reprogramming of glioblastoma cells by L-asparaginase sensitizes for apoptosis in vitro and in vivo

https://doi.org/10.18632/oncotarget.9257

Georg Karpel-Massler, Doruntina Ramani, Chang Shu, Marc-Eric Halatsch, Mike-Andrew Westhoff, Jeffrey N. Bruce, Peter Canoll,  and Markus D. Siegelin
33512-33528
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Interview with Dr. Markus D. Siegelin & Dr. Georg Karpel-Massler  |  Order a Reprint

Conjugation to the sigma-2 ligand SV119 overcomes uptake blockade and converts dm-Erastin into a potent pancreatic cancer therapeutic

Conjugation to the sigma-2 ligand SV119 overcomes uptake blockade and converts dm-Erastin into a potent pancreatic cancer therapeutic

https://doi.org/10.18632/oncotarget.9551

Kerri A. Ohman, Yassar M. Hashim, Suwanna Vangveravong, Timothy M. Nywening, Darren R. Cullinan, S. Peter Goedegebuure, Jingxia Liu, Brian A. Van Tine, Herve Tiriac, David A. Tuveson, David G. DeNardo, Dirk Spitzer, Robert H. Mach,  and William G. Hawkins
33529-33541
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Dual inhibition of protein kinase C and p53-MDM2 or PKC and mTORC1 are novel efficient therapeutic approaches for uveal melanoma

Dual inhibition of protein kinase C and p53-MDM2 or PKC and mTORC1 are novel efficient therapeutic approaches for uveal melanoma

https://doi.org/10.18632/oncotarget.9552

Guillaume Carita, Estelle Frisch-Dit-Leitz, Ahmed Dahmani, Chloé Raymondie, Nathalie Cassoux, Sophie Piperno-Neumann, Fariba Némati, Cécile Laurent, Leanne De Koning, Ensar Halilovic, Sebastien Jeay, Andrew Wylie, Caroline Emery, Sergio Roman-Roman, Marie Schoumacher,  and Didier Decaudin
33542-33556
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

β2-spectrin depletion impairs DNA damage repair

β2-spectrin depletion impairs DNA damage repair

https://doi.org/10.18632/oncotarget.9677

Nobuo Horikoshi, Raj K. Pandita, Kalpana Mujoo, Shashank Hambarde, Dharmendra Sharma, Abid R. Mattoo, Sharmistha Chakraborty, Vijaya Charaka, Clayton R. Hunt,  and Tej K. Pandita
33557-33570
Abstract  |  PDF  |  HTML  |  Order a Reprint

Targeting hypoxic microenvironment of pancreatic xenografts with the hypoxia-activated prodrug TH-302

Targeting hypoxic microenvironment of pancreatic xenografts with the hypoxia-activated prodrug TH-302

https://doi.org/10.18632/oncotarget.9654

Ines Lohse, Joanna Rasowski, Pinjiang Cao, Melania Pintilie, Trevor Do, Ming-Sound Tsao, Richard P. Hill,  and David W. Hedley
33571-33580
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Research Papers: Gerotarget (Focus on Aging)

Vaccine efficacy and T helper cell differentiation change with aging

Vaccine efficacy and T helper cell differentiation change with aging

https://doi.org/10.18632/oncotarget.9254

Julie S. Lefebvre, Erica C. Lorenzo, April R. Masters, Jacob W. Hopkins, Sheri M. Eaton, Stephen T. Smiley,  and Laura Haynes
33581-33594
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Thigh muscle size and vascular function after blood flow-restricted elastic band training in older women

Thigh muscle size and vascular function after blood flow-restricted elastic band training in older women

https://doi.org/10.18632/oncotarget.9564

Tomohiro Yasuda, Kazuya Fukumura, Takanobu Tomaru,  and Toshiaki Nakajima
33595-33607
Abstract  |  PDF  |  HTML  |  Order a Reprint

Research Papers: Pathology

Risk prediction for early-onset gastric carcinoma: a case-control study of polygenic gastric cancer in Han Chinese with hereditary background

Risk prediction for early-onset gastric carcinoma: a case-control study of polygenic gastric cancer in Han Chinese with hereditary background

https://doi.org/10.18632/oncotarget.9025

Jiajia Yuan, Yanyan Li, Tiantian Tian, Na Li, Yan Zhu, Jianling Zou, Jing Gao,  and Lin Shen
33608-33615
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Functional networks of aging markers in the glomeruli of IgA nephropathy: a new therapeutic opportunity

Functional networks of aging markers in the glomeruli of IgA nephropathy: a new therapeutic opportunity

https://doi.org/10.18632/oncotarget.9033

Hong Jiang, Ludan Liang, Jing Qin, Yingying Lu, Bingjue Li, Yucheng Wang, Chuan Lin, Qin Zhou, Shi Feng, Shun H. Yip, Feng Xu, EnYin Lai, Junwen Wang,  and Jianghua Chen
33616-33626
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

An integrated proteomics approach shows synaptic plasticity changes in an APP/PS1 Alzheimer's mouse model

An integrated proteomics approach shows synaptic plasticity changes in an APP/PS1 Alzheimer's mouse model

https://doi.org/10.18632/oncotarget.9092

Stefan J. Kempf, Athanasios Metaxas, María Ibáñez-Vea, Sultan Darvesh, Bente Finsen,  and Martin R. Larsen
33627-33648
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IL-33 treatment attenuated diet-induced hepatic steatosis but aggravated hepatic fibrosis

IL-33 treatment attenuated diet-induced hepatic steatosis but aggravated hepatic fibrosis

https://doi.org/10.18632/oncotarget.9259

Yinjie Gao, Yuan Liu, Mei Yang, Xiaodong Guo, Min Zhang, Hanwei Li, Jin Li,  and Jingmin Zhao
33649-33661
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

NPR-C gene polymorphism is associated with increased susceptibility to coronary artery disease in Chinese Han population: a multicenter study

NPR-C gene polymorphism is associated with increased susceptibility to coronary artery disease in Chinese Han population: a multicenter study

https://doi.org/10.18632/oncotarget.9358

Qin Hu, Qiji Liu, Shasha Wang, Xi Zhen, Zhimian Zhang, Ruijuan Lv, Guihua Jiang, Zhiyong Ma, Hong He, Daqing Li, Xiaoling Liu, Fei Gao, Jifu Li, Li Li, Mei Zhang, Xiaoping Ji, Yuguo Chen, Daowen Wang, Dejia Huang, Aiqun Ma, Wei Huang, Yuxia Zhao, Yaoqin Gong, Cheng Zhang,  and Yun Zhang
33662-33674
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Distinctive expression patterns of hypoxia-inducible factor-1α and endothelial nitric oxide synthase following hypergravity exposure

Distinctive expression patterns of hypoxia-inducible factor-1α and endothelial nitric oxide synthase following hypergravity exposure

https://doi.org/10.18632/oncotarget.9372

Gun Yoon, Choong Sik Oh,  and Hyun-Soo Kim
33675-33688
Abstract  |  PDF  |  HTML  |  Order a Reprint

Organochloride pesticides induced hepatic ABCG5/G8 expression and lipogenesis in Chinese patients with gallstone disease

Organochloride pesticides induced hepatic ABCG5/G8 expression and lipogenesis in Chinese patients with gallstone disease

https://doi.org/10.18632/oncotarget.9399

Guixiang Ji, Cheng Xu, Haidong Sun, Qian Liu, Hai Hu, Aihua Gu,  and Zhao-Yan Jiang
33689-33702
Abstract  |  PDF  |  HTML  |  Order a Reprint

Pulmonary fibrosis in a mouse model of sarcoid granulomatosis induced by booster challenge with Propionibacterium acnes

Pulmonary fibrosis in a mouse model of sarcoid granulomatosis induced by booster challenge with Propionibacterium acnes

https://doi.org/10.18632/oncotarget.9397

Dingyuan Jiang, Xiaoxi Huang, Jing Geng, Run Dong, Shuhong Li, Zheng Liu, Chen Wang,  and Huaping Dai
33703-33714
Abstract  |  PDF  |  HTML  |  Order a Reprint

Polycystic ovary syndrome (PCOS) and the risk of coronary heart disease (CHD): a meta-analysis

Polycystic ovary syndrome (PCOS) and the risk of coronary heart disease (CHD): a meta-analysis

https://doi.org/10.18632/oncotarget.9553

Luqian Zhao, Zhigang Zhu, Huiling Lou, Guodong Zhu, Weimin Huang, Shaogang Zhang,  and Feng Liu
33715-33721
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Use of estetrol with other steroids for attenuation of neonatal hypoxic-Ischemic brain injury: to combine or not to combine?

Use of estetrol with other steroids for attenuation of neonatal hypoxic-Ischemic brain injury: to combine or not to combine?

https://doi.org/10.18632/oncotarget.9591

Ekaterine Tskitishvili, Christel Pequeux, Carine Munaut, Renaud Viellevoye, Michelle Nisolle, Agnes Noël,  and Jean-Michel Foidart
33722-33743
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Research Papers: Immunology

Unexpected positive control of NFκB and miR-155 by DGKα and ζ ensures effector and memory CD8+ T cell differentiation

Unexpected positive control of NFκB and miR-155 by DGKα and ζ ensures effector and memory CD8+ T cell differentiation

https://doi.org/10.18632/oncotarget.8164

Jialong Yang, Ping Zhang, Sruti Krishna, Jinli Wang, Xingguang Lin, Hongxiang Huang, Danli Xie, Balachandra Gorentla, Rick Huang, Jimin Gao, Qi-Jing Li,  and Xiao-Ping Zhong
33744-33764
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Cisplatin induces tolerogenic dendritic cells in response to TLR agonists via the abundant production of IL-10, thereby promoting Th2- and Tr1-biased T-cell immunity

Cisplatin induces tolerogenic dendritic cells in response to TLR agonists via the abundant production of IL-10, thereby promoting Th2- and Tr1-biased T-cell immunity

https://doi.org/10.18632/oncotarget.9260

Woo Sik Kim, Hongmin Kim, Kee Woong Kwon, Sin-Hyeog Im, Bo Ryeong Lee, Sang-Jun Ha,  and Sung Jae Shin
33765-33782
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

AMPK-dependent and independent effects of AICAR and compound C on T-cell responses

AMPK-dependent and independent effects of AICAR and compound C on T-cell responses

https://doi.org/10.18632/oncotarget.9277

Enyu Rao, Yuwen Zhang, Qiang Li, Jiaqing Hao, Nejat K. Egilmez, Jill Suttles,  and Bing Li
33783-33795
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

HCV core protein binds to gC1qR to induce A20 expression and inhibit cytokine production through MAPKs and NF-κB signaling pathways

HCV core protein binds to gC1qR to induce A20 expression and inhibit cytokine production through MAPKs and NF-κB signaling pathways

https://doi.org/10.18632/oncotarget.9304

Xiaotian Song, Zhiyan Yao, Jianling Yang, Zhengzheng Zhang, Yuqing Deng, Miao Li, Cuiqing Ma, Lijuan Yang, Xue Gao, Wenjian Li, Jianguo Liu,  and Lin Wei
33796-33808
Abstract  |  PDF  |  HTML  |  Order a Reprint

Research Papers: Chromosome

Translin and Trax differentially regulate telomere-associated transcript homeostasis

Translin and Trax differentially regulate telomere-associated transcript homeostasis

https://doi.org/10.18632/oncotarget.9278

Natalia Gomez-Escobar, Nasser Almobadel, Othman Alzahrani, Julia Feichtinger, Vicente Planells-Palop, Zafer Alshehri, Gerhard G. Thallinger, Jane A. Wakeman,  and Ramsay J. McFarlane
33809-33820
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Research Papers

Rheb may complex with RASSF1A to coordinate Hippo and TOR signaling

Rheb may complex with RASSF1A to coordinate Hippo and TOR signaling

https://doi.org/10.18632/oncotarget.8447

Nicholas Nelson,  and Geoffrey J. Clark
33821-33831
Abstract  |  PDF  |  HTML  |  Order a Reprint

Loss of adipose triglyceride lipase is associated with human cancer and induces mouse pulmonary neoplasia

Loss of adipose triglyceride lipase is associated with human cancer and induces mouse pulmonary neoplasia

https://doi.org/10.18632/oncotarget.9418

Wael Al-Zoughbi, Martin Pichler, Gregor Gorkiewicz, Barbara Guertl-Lackner, Johannes Haybaeck, Stephan W. Jahn, Carolin Lackner, Bernadette Liegl-Atzwanger, Helmut Popper, Silvia Schauer, Elisa Nusshold, Alida S. D. Kindt, Zlatko Trajanoski, Michael R. Speicher, Guenther Haemmerle, Robert Zimmermann, Rudolf Zechner, Paul W. Vesely,  and Gerald Hoefler
33832-33840
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Preventive and therapeutic effects of thymosin β4 N-terminal fragment Ac-SDKP in the bleomycin model of pulmonary fibrosis

Preventive and therapeutic effects of thymosin β4 N-terminal fragment Ac-SDKP in the bleomycin model of pulmonary fibrosis

https://doi.org/10.18632/oncotarget.8409

Enrico Conte, Evelina Fagone, Elisa Gili, Mary Fruciano, Maria Iemmolo, Maria Provvidenza Pistorio, Daniela Impellizzeri, Marika Cordaro, Salvatore Cuzzocrea,  and Carlo Vancheri
33841-33854
Abstract  |  PDF  |  HTML  |  Order a Reprint

Gene expression in normal-appearing tissue adjacent to prostate cancers are predictive of clinical outcome: evidence for a biologically meaningful field effect

Gene expression in normal-appearing tissue adjacent to prostate cancers are predictive of clinical outcome: evidence for a biologically meaningful field effect

https://doi.org/10.18632/oncotarget.8944

Cristina Magi-Galluzzi, Tara Maddala, Sara Moscovita Falzarano, Diana B. Cherbavaz, Nan Zhang, Dejan Knezevic, Phillip G. Febbo, Mark Lee, Hugh Jeffrey Lawrence,  and Eric A. Klein
33855-33865
Abstract  |  PDF  |  HTML  |  Order a Reprint

IAP antagonists sensitize murine osteosarcoma cells to killing by TNFα

IAP antagonists sensitize murine osteosarcoma cells to killing by TNFα

https://doi.org/10.18632/oncotarget.8980

Tanmay M. Shekhar, Mark A. Miles, Ankita Gupte, Scott Taylor, Brianna Tascone, Carl R. Walkley,  and Christine J. Hawkins
33866-33886
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Dysregulation of junctional adhesion molecule-A via p63/GATA-3 in head and neck squamous cell carcinoma

Dysregulation of junctional adhesion molecule-A via p63/GATA-3 in head and neck squamous cell carcinoma

https://doi.org/10.18632/oncotarget.8432

Takuya Kakuki, Makoto Kurose, Ken-ichi Takano, Atsushi Kondoh, Kazufumi Obata, Kazuaki Nomura, Ryo Miyata, Yakuto Kaneko, Takumi Konno, Syunta Takahashi, Tsubasa Hatakeyama, Takayuki Kohno, Tetsuo Himi,  and Takashi Kojima
33887-33900
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Neoadjuvant tamoxifen synchronizes ERα binding and gene expression profiles related to outcome and proliferation

Neoadjuvant tamoxifen synchronizes ERα binding and gene expression profiles related to outcome and proliferation

https://doi.org/10.18632/oncotarget.8983

Tesa M. Severson, Ekaterina Nevedomskaya, Justine Peeters, Thomas Kuilman, Oscar Krijgsman, Annelot van Rossum, Marjolein Droog, Yongsoo Kim, Rutger Koornstra, Inès Beumer, Annuska M. Glas, Daniel Peeper, Jelle Wesseling, Iris M. Simon, Lodewyk Wessels, Sabine C. Linn,  and Wilbert Zwart
33901-33918
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Repurposing cephalosporin antibiotics as pro-senescent radiosensitizers

Repurposing cephalosporin antibiotics as pro-senescent radiosensitizers

https://doi.org/10.18632/oncotarget.8984

Edwardine Labay, Helena J. Mauceri, Elena V. Efimova, Amy C. Flor, Harold G. Sutton, Stephen J. Kron,  and Ralph R. Weichselbaum
33919-33933
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The long non-coding RNA PARROT is an upstream regulator of c-Myc and affects proliferation and translation

The long non-coding RNA PARROT is an upstream regulator of c-Myc and affects proliferation and translation

https://doi.org/10.18632/oncotarget.8985

Dubravka Vučićević, Maja Gehre, Sonam Dhamija, Lennart Friis-Hansen, David Meierhofer, Sascha Sauer,  and Ulf Andersson Ørom
33934-33947
Abstract  |  PDF  |  HTML  |  Order a Reprint

Ergosterol peroxide activates Foxo3-mediated cell death signaling by inhibiting AKT and c-Myc in human hepatocellular carcinoma cells

Ergosterol peroxide activates Foxo3-mediated cell death signaling by inhibiting AKT and c-Myc in human hepatocellular carcinoma cells

https://doi.org/10.18632/oncotarget.8608

Xiangmin Li, Qingping Wu, Ming Bu, Liming Hu, William W. Du, Chunwei Jiao, Honghui Pan, Mouna Sdiri, Nan Wu, Yizhen Xie,  and Burton B. Yang
33948-33959
Abstract  |  PDF  |  HTML  |  Order a Reprint

­­­­Cyclic AMP efflux inhibitors as potential therapeutic agents for leukemia

­­­­Cyclic AMP efflux inhibitors as potential therapeutic agents for leukemia

https://doi.org/10.18632/oncotarget.8986

Dominique R. Perez, Yelena Smagley, Matthew Garcia, Mark B. Carter, Annette Evangelisti, Ksenia Matlawska-Wasowska, Stuart S. Winter, Larry A. Sklar,  and Alexandre Chigaev
33960-33982
Abstract  |  PDF  |  HTML  |  Order a Reprint

GCGene: a gene resource for gastric cancer with literature evidence

GCGene: a gene resource for gastric cancer with literature evidence

https://doi.org/10.18632/oncotarget.9030

Min Zhao, Luming Chen, Yining Liu,  and Hong Qu
33983-33993
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Extracellular miRNA-21 as a novel biomarker in glioma: evidence from meta-analysis, clinical validation and experimental investigations

Extracellular miRNA-21 as a novel biomarker in glioma: evidence from meta-analysis, clinical validation and experimental investigations

https://doi.org/10.18632/oncotarget.9188

Kai Qu, Ting Lin, Qing Pang, Tian Liu, Zhixin Wang, Minghui Tai, Fandi Meng, Jingyao Zhang, Yong Wan, Ping Mao, Xiaoqun Dong, Chang Liu, Wenquan Niu,  and Shunbin Dong
33994-34010
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Direct repression of the oncogene CDK4 by the tumor suppressor miR-486-5p in non-small cell lung cancer

Direct repression of the oncogene CDK4 by the tumor suppressor miR-486-5p in non-small cell lung cancer

https://doi.org/10.18632/oncotarget.8514

Yang Shao, Yu-Qing Shen, Yan-Li Li, Chen Liang, Bing-Jie Zhang, Sheng-Di Lu, Yan-Yun He, Ping Wang, Qiang-Ling Sun, You-Xin Jin,  and Zhong-Liang Ma
34011-34021
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Identification of nasopharyngeal carcinoma metastasis-related biomarkers by iTRAQ combined with 2D-LC-MS/MS

Identification of nasopharyngeal carcinoma metastasis-related biomarkers by iTRAQ combined with 2D-LC-MS/MS

https://doi.org/10.18632/oncotarget.9067

Zhen Chen, Lu Long, Kun Wang, Facai Cui, Lepan Zhu, Ya Tao, Qiong Wu, Manlin Xiang, Yunlai Liang, Shiyang Qiu, Zhiqiang Xiao,  and Bin Yi
34022-34037
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Lapatinib-loaded human serum albumin nanoparticles for the prevention and treatment of triple-negative breast cancer metastasis to the brain

Lapatinib-loaded human serum albumin nanoparticles for the prevention and treatment of triple-negative breast cancer metastasis to the brain

https://doi.org/10.18632/oncotarget.8697

Xu Wan, Xiaoyao Zheng, Xiaoyin Pang, Zhiqing Pang, Jingjing Zhao, Zheming Zhang, Tao Jiang, Wei Xu, Qizhi Zhang,  and Xinguo Jiang
34038-34051
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

HIF-1-alpha links mitochondrial perturbation to the dynamic acquisition of breast cancer tumorigenicity

HIF-1-alpha links mitochondrial perturbation to the dynamic acquisition of breast cancer tumorigenicity

https://doi.org/10.18632/oncotarget.8570

Ching-Ying Kuo, Chun-Ting Cheng, Peifeng Hou, Yi-Pei Lin, Huimin Ma, Yiyin Chung, Kevin Chi, Yuan Chen, Wei Li, Hsing-Jien Kung,  and David K. Ann
34052-34069
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Novel CD7-specific nanobody-based immunotoxins potently enhanced apoptosis of CD7-positive malignant cells

Novel CD7-specific nanobody-based immunotoxins potently enhanced apoptosis of CD7-positive malignant cells

https://doi.org/10.18632/oncotarget.8710

Jinle Tang, Jialu Li, Xuejun Zhu, Yuan Yu, Dan Chen, Lei Yuan, Zhenyang Gu, Xingding Zhang, Lin Qi, Zhishu Gong, Pengjun Jiang, Juhua Yu, Huimin Meng, Gangli An, Huyong Zheng,  and Lin Yang
34070-34083
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Repurposing atovaquone: Targeting mitochondrial complex III and OXPHOS to eradicate cancer stem cells

Repurposing atovaquone: Targeting mitochondrial complex III and OXPHOS to eradicate cancer stem cells

https://doi.org/10.18632/oncotarget.9122

Marco Fiorillo, Rebecca Lamb, Herbert B. Tanowitz, Luciano Mutti, Marija Krstic-Demonacos, Anna Rita Cappello, Ubaldo E. Martinez-Outschoorn, Federica Sotgia,  and Michael P. Lisanti
34084-34099
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Radiosynthesis and preliminary biological evaluation of N-(2-[18F]fluoropropionyl)-L-glutamine as a PET tracer for tumor imaging

Radiosynthesis and preliminary biological evaluation of N-(2-[18F]fluoropropionyl)-L-glutamine as a PET tracer for tumor imaging

https://doi.org/10.18632/oncotarget.9115

Caihua Tang, Ganghua Tang, Siyuan Gao, Shaoyu Liu, Fuhua Wen, Baoguo Yao,  and Dahong Nie
34100-34111
Abstract  |  PDF  |  HTML  |  Order a Reprint

Inhibition of PHLPP2/cyclin D1 protein translation contributes to the tumor suppressive effect of NFκB2 (p100)

Inhibition of PHLPP2/cyclin D1 protein translation contributes to the tumor suppressive effect of NFκB2 (p100)

https://doi.org/10.18632/oncotarget.8746

Jiawei Xu, Yulei Wang, Xiaohui Hua, Jiheng Xu, Zhongxian Tian, Honglei Jin, Jingxia Li, Xue-Ru Wu,  and Chuanshu Huang
34112-34130
Abstract  |  PDF  |  HTML  |  Order a Reprint

Anti-tumor effect of estrogen-related receptor alpha knockdown on uterine endometrial cancer

Anti-tumor effect of estrogen-related receptor alpha knockdown on uterine endometrial cancer

https://doi.org/10.18632/oncotarget.9151

Hiroshi Matsushima, Taisuke Mori, Fumitake Ito, Takuro Yamamoto, Makoto Akiyama, Tetsuya Kokabu, Kaori Yoriki, Shiori Umemura, Kyoko Akashi,  and Jo Kitawaki
34131-34148
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Can an IL13 -1112 C/T (rs1800925) polymorphism predict responsiveness to neoadjuvant chemoradiotherapy and survival of Chinese Han patients with locally advanced rectal cancer?

Can an IL13 -1112 C/T (rs1800925) polymorphism predict responsiveness to neoadjuvant chemoradiotherapy and survival of Chinese Han patients with locally advanced rectal cancer?

https://doi.org/10.18632/oncotarget.9178

Lin Xiao, Xin Yu, Rong Zhang, Hui Chang, Shaoyan Xi, Weiwei Xiao, Zhifan Zeng, Huizhong Zhang, Ruihua Xu,  and Yuanhong Gao
34149-34157
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Hyaluronic acid-conjugated liposome nanoparticles for targeted delivery to CD44 overexpressing glioblastoma cells

Hyaluronic acid-conjugated liposome nanoparticles for targeted delivery to CD44 overexpressing glioblastoma cells

https://doi.org/10.18632/oncotarget.8926

Stephen L. Hayward, Christina L. Wilson,  and Srivatsan Kidambi
34158-34171
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Human umbilical cord matrix-derived stem cells expressing interferon-β gene inhibit breast cancer cells via apoptosis

Human umbilical cord matrix-derived stem cells expressing interferon-β gene inhibit breast cancer cells via apoptosis

https://doi.org/10.18632/oncotarget.8997

Ching-Ju Shen, Te-Fu Chan, Chien-Chung Chen, Yi-Chiang Hsu, Cheng-Yu Long,  and Chung-Sheng Lai
34172-34179
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iROS-gPseKNC: Predicting replication origin sites in DNA by incorporating dinucleotide position-specific propensity into general pseudo nucleotide composition

iROS-gPseKNC: Predicting replication origin sites in DNA by incorporating dinucleotide position-specific propensity into general pseudo nucleotide composition

https://doi.org/10.18632/oncotarget.9057

Xuan Xiao, Han-Xiao Ye, Zi Liu, Jian-Hua Jia,  and Kuo-Chen Chou
34180-34189
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

PKG II reverses HGF-triggered cellular activities by phosphorylating serine 985 of c-Met in gastric cancer cells

PKG II reverses HGF-triggered cellular activities by phosphorylating serine 985 of c-Met in gastric cancer cells

https://doi.org/10.18632/oncotarget.9074

Yan Wu, Xiaoyuan Yao, Miaolin Zhu, Hai Qian, Lu Jiang, Ting Lan, Min Wu, Ji Pang,  and Yongchang Chen
34190-34200
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Th17 cytokine differentiation and loss of plasticity after SOCS1 inactivation in a cutaneous T-cell lymphoma

Th17 cytokine differentiation and loss of plasticity after SOCS1 inactivation in a cutaneous T-cell lymphoma

https://doi.org/10.18632/oncotarget.9077

Stefan Ehrentraut, Björn Schneider, Stefan Nagel, Claudia Pommerenke, Hilmar Quentmeier, Robert Geffers, Maren Feist, Maren Kaufmann, Corinna Meyer, Marshall E. Kadin, Hans G. Drexler,  and Roderick A. F. MacLeod
34201-34216
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Prognostic impact of tumor-associated macrophage infiltration in non-small cell lung cancer: A systemic review and meta-analysis

Prognostic impact of tumor-associated macrophage infiltration in non-small cell lung cancer: A systemic review and meta-analysis

https://doi.org/10.18632/oncotarget.9079

Jiandong Mei, Zhilan Xiao, Chenglin Guo, Qiang Pu, Lin Ma, Chengwu Liu, Feng Lin, Hu Liao, Zongbing You,  and Lunxu Liu
34217-34228
Abstract  |  PDF  |  HTML  |  Order a Reprint

XAF1 promotes neuroblastoma tumor suppression and is required for KIF1Bβ-mediated apoptosis

XAF1 promotes neuroblastoma tumor suppression and is required for KIF1Bβ-mediated apoptosis

https://doi.org/10.18632/oncotarget.8748

Zhang'e Choo, Rachel Yu Lin Koh, Karin Wallis, Timothy Jia Wei Koh, Chik Hong Kuick, Veronica Sobrado, Rajappa S. Kenchappa, Amos Hong Pheng Loh, Shui Yen Soh, Susanne Schlisio, Kenneth Tou En Chang,  and Zhi Xiong Chen
34229-34239
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Genetic alterations and protein expression in combined small cell lung cancers and small cell lung cancers arising from lung adenocarcinomas after therapy with tyrosine kinase inhibitors

Genetic alterations and protein expression in combined small cell lung cancers and small cell lung cancers arising from lung adenocarcinomas after therapy with tyrosine kinase inhibitors

https://doi.org/10.18632/oncotarget.9083

Xiaohua Shi, Huanli Duan, Xuguang Liu, Liangrui Zhou,  and Zhiyong Liang
34240-34249
Abstract  |  PDF  |  HTML  |  Order a Reprint

Exogenous carbon monoxide inhibits neutrophil infiltration in LPS-induced sepsis by interfering with FPR1 via p38 MAPK but not GRK2

Exogenous carbon monoxide inhibits neutrophil infiltration in LPS-induced sepsis by interfering with FPR1 via p38 MAPK but not GRK2

https://doi.org/10.18632/oncotarget.9084

Xu Wang, Weiting Qin, Mingming Song, Yisen Zhang,  and Bingwei Sun
34250-34265
Abstract  |  PDF  |  HTML  |  Order a Reprint

Quinazoline derivative QPB-15e stabilizes the c-myc promoter G-quadruplex and inhibits tumor growth in vivo

Quinazoline derivative QPB-15e stabilizes the c-myc promoter G-quadruplex and inhibits tumor growth in vivo

https://doi.org/10.18632/oncotarget.9088

Zeng Li, Chen Liu, Cheng Huang, Xiaoming Meng, Lei Zhang, Jinhui He,  and Jun Li
34266-34276
Abstract  |  PDF  |  HTML  |  Order a Reprint

A functional single nucleotide polymorphism of SET8 is prognostic for breast cancer

A functional single nucleotide polymorphism of SET8 is prognostic for breast cancer

https://doi.org/10.18632/oncotarget.9099

Ben Liu, Xining Zhang, Fengju Song, Qun Liu, Hongji Dai, Hong Zheng, Ping Cui, Lina Zhang, Wei Zhang,  and Kexin Chen
34277-34287
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Identification of miR-34a-target interactions by a combined network based and experimental approach

Identification of miR-34a-target interactions by a combined network based and experimental approach

https://doi.org/10.18632/oncotarget.9103

Martin Hart, Stefanie Rheinheimer, Petra Leidinger, Christina Backes, Jennifer Menegatti, Tobias Fehlmann, Friedrich Grässer, Andreas Keller,  and Eckart Meese
34288-34299
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Wogonoside prevents colitis-associated colorectal carcinogenesis and colon cancer progression in inflammation-related microenvironment via inhibiting NF-κB activation through PI3K/Akt pathway

Wogonoside prevents colitis-associated colorectal carcinogenesis and colon cancer progression in inflammation-related microenvironment via inhibiting NF-κB activation through PI3K/Akt pathway

https://doi.org/10.18632/oncotarget.8815

Yang Sun, Yue Zhao, Xiaoping Wang, Li Zhao, Wenjun Li, Youxiang Ding, Lingyi Kong, Qinglong Guo,  and Na Lu
34300-34315
Abstract  |  PDF  |  HTML  |  Order a Reprint

Genetic variant of miR-146a rs2910164 C>G and gastric cancer susceptibility

Genetic variant of miR-146a rs2910164 C>G and gastric cancer susceptibility

https://doi.org/10.18632/oncotarget.8814

Zu-Guang Xia, Hua-Fang Yin, Ying Long, Lei Cheng, Ling-Jun Yu, Wei-Jian Guo, Xiao-Dong Zhu, Jin Li, Ya-Nong Wang, Ya-Jun Yang, Jiu-Cun Wang, Li Jin, Li-Xin Qiu,  and Yongyue Wei
34316-34321
Abstract  |  PDF  |  HTML  |  Order a Reprint

MEK5/ERK5 signaling inhibition increases colon cancer cell sensitivity to 5-fluorouracil through a p53-dependent mechanism

MEK5/ERK5 signaling inhibition increases colon cancer cell sensitivity to 5-fluorouracil through a p53-dependent mechanism

https://doi.org/10.18632/oncotarget.9107

Diane M. Pereira, André E. S. Simões, Sofia E. Gomes, Rui E. Castro, Tânia Carvalho, Cecília M. P. Rodrigues,  and Pedro M. Borralho
34322-34340
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Chimeric antigen receptor T cells secreting anti-PD-L1 antibodies more effectively regress renal cell carcinoma in a humanized mouse model

Chimeric antigen receptor T cells secreting anti-PD-L1 antibodies more effectively regress renal cell carcinoma in a humanized mouse model

https://doi.org/10.18632/oncotarget.9114

Eloah Rabello Suarez, De-Kuan Chang, Jiusong Sun, Jianhua Sui, Gordon J. Freeman, Sabina Signoretti, Quan Zhu,  and Wayne A. Marasco
34341-34355
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Asparaginyl endopeptidase promotes the invasion and metastasis of gastric cancer through modulating epithelial-to-mesenchymal transition

Asparaginyl endopeptidase promotes the invasion and metastasis of gastric cancer through modulating epithelial-to-mesenchymal transition

https://doi.org/10.18632/oncotarget.8879

Yuehong Cui, Yan Wang, Hong Li, Qian Li, Yiyi Yu, Xiaojing Xu, Bei Xu,  and Tianshu Liu
34356-34370
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

FRA1 promotes squamous cell carcinoma growth and metastasis through distinct AKT and c-Jun dependent mechanisms

FRA1 promotes squamous cell carcinoma growth and metastasis through distinct AKT and c-Jun dependent mechanisms

https://doi.org/10.18632/oncotarget.9110

Xiaoling Zhang, Joseph Wu, Suju Luo, Terry Lechler,  and Jennifer Y. Zhang
34371-34383
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Identification of cytotoxic agents disrupting synovial sarcoma oncoprotein interactions by proximity ligation assay

Identification of cytotoxic agents disrupting synovial sarcoma oncoprotein interactions by proximity ligation assay

https://doi.org/10.18632/oncotarget.8882

Aimée N. Laporte, Jennifer X. Ji, Limin Ma, Torsten O. Nielsen,  and Bertha A. Brodin
34384-34394
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Multiplicity of acquired cross-resistance in paclitaxel-resistant cancer cells is associated with feedback control of TUBB3 via FOXO3a-mediated ABCB1 regulation

Multiplicity of acquired cross-resistance in paclitaxel-resistant cancer cells is associated with feedback control of TUBB3 via FOXO3a-mediated ABCB1 regulation

https://doi.org/10.18632/oncotarget.9118

Mark Borris D. Aldonza, Ji-Young Hong, Malona V. Alinsug, Jayoung Song,  and Sang Kook Lee
34395-34419
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Autophagy suppresses cell migration by degrading GEF-H1, a RhoA GEF

Autophagy suppresses cell migration by degrading GEF-H1, a RhoA GEF

https://doi.org/10.18632/oncotarget.8883

Tatsushi Yoshida, Masatsune Tsujioka, Shinya Honda, Masato Tanaka,  and Shigeomi Shimizu
34420-34429
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

AT101 exerts a synergetic efficacy in gastric cancer patients with 5-FU based treatment through promoting apoptosis and autophagy

AT101 exerts a synergetic efficacy in gastric cancer patients with 5-FU based treatment through promoting apoptosis and autophagy

https://doi.org/10.18632/oncotarget.9119

Xi Wei, Wei Duan, Ying Li, Sheng Zhang, Xiaojie Xin, Lei Sun, Ming Gao, Qing Li,  and Dong Wang
34430-34441
Abstract  |  PDF  |  HTML  |  Order a Reprint

Metformin restores crizotinib sensitivity in crizotinib-resistant human lung cancer cells through inhibition of IGF1-R signaling pathway

Metformin restores crizotinib sensitivity in crizotinib-resistant human lung cancer cells through inhibition of IGF1-R signaling pathway

https://doi.org/10.18632/oncotarget.9120

Li Li, Yubo Wang, Tao Peng, Kejun Zhang, Caiyu Lin, Rui Han, Conghua Lu,  and Yong He
34442-34452
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Obatoclax kills anaplastic thyroid cancer cells by inducing lysosome neutralization and necrosis

Obatoclax kills anaplastic thyroid cancer cells by inducing lysosome neutralization and necrosis

https://doi.org/10.18632/oncotarget.9121

Devora Champa, Arturo Orlacchio, Bindi Patel, Michela Ranieri, Anton A Shemetov, Vladislav V Verkhusha, Ana Maria Cuervo,  and Antonio Di Cristofano
34453-34471
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A functional variant at miRNA-122 binding site in IL-1α 3 19; UTR predicts risk of recurrence in patients with oropharyngeal cancer

A functional variant at miRNA-122 binding site in IL-1α 3 19; UTR predicts risk of recurrence in patients with oropharyngeal cancer

https://doi.org/10.18632/oncotarget.8908

Chengyuan Wang, Erich M. Sturgis, Xingming Chen, Qingyi Wei,  and Guojun Li
34472-34479
Abstract  |  PDF  |  HTML  |  Order a Reprint

p75 neurotrophin receptor and pro-BDNF promote cell survival and migration in clear cell renal cell carcinoma

p75 neurotrophin receptor and pro-BDNF promote cell survival and migration in clear cell renal cell carcinoma

https://doi.org/10.18632/oncotarget.8911

Miguel A. De la Cruz-Morcillo, Julien Berger, Ricardo Sánchez-Prieto, Sofiane Saada, Thomas Naves, Angélique Guillaudeau, Aurélie Perraud, Philippe Sindou, Aurélie Lacroix, Aurélien Descazeaud, Fabrice Lalloué,  and Marie-Odile Jauberteau
34480-34497
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MicroRNA-21 as a potential diagnostic biomarker for breast cancer patients: a pooled analysis of individual studies

MicroRNA-21 as a potential diagnostic biomarker for breast cancer patients: a pooled analysis of individual studies

https://doi.org/10.18632/oncotarget.9142

Ying Gao, Qiliang Cai, Yubei Huang, Shu Li, Hongxi Yang, Li Sun, Kexin Chen,  and Yaogang Wang
34498-34506
Abstract  |  PDF  |  HTML  |  Order a Reprint

Stroma-derived but not tumor ADAMTS1 is a main driver of tumor growth and metastasis

Stroma-derived but not tumor ADAMTS1 is a main driver of tumor growth and metastasis

https://doi.org/10.18632/oncotarget.8922

Rubén Fernández-Rodríguez, Francisco Javier Rodríguez-Baena, Estefanía Martino-Echarri, Carlos Peris-Torres, María del Carmen Plaza-Calonge,  and Juan Carlos Rodríguez-Manzaneque
34507-34519
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Association of SOX2 and Nestin DNA amplification and protein expression with clinical features and overall survival in non-small cell lung cancer: A systematic review and meta-analysis

Association of SOX2 and Nestin DNA amplification and protein expression with clinical features and overall survival in non-small cell lung cancer: A systematic review and meta-analysis

https://doi.org/10.18632/oncotarget.9145

Qingbao Li, Fang Liu, Yuan Zhang, Lei Fu, Cong Wang, Xuan Chen, Shanghui Guan,  and Xiangjiao Meng
34520-34531
Abstract  |  PDF  |  HTML  |  Order a Reprint

MnTnBuOE-2-PyP protects normal colorectal fibroblasts from radiation damage and simultaneously enhances radio/chemotherapeutic killing of colorectal cancer cells

MnTnBuOE-2-PyP protects normal colorectal fibroblasts from radiation damage and simultaneously enhances radio/chemotherapeutic killing of colorectal cancer cells

https://doi.org/10.18632/oncotarget.8923

Elizabeth A. Kosmacek, Arpita Chatterjee, Qiang Tong, Chi Lin,  and Rebecca E. Oberley-Deegan
34532-34545
Abstract  |  PDF  |  HTML  |  Order a Reprint

A meta-analysis of MSI frequency and race in colorectal cancer

A meta-analysis of MSI frequency and race in colorectal cancer

https://doi.org/10.18632/oncotarget.8945

Hassan Ashktorab, Sadhna Ahuja, Lakshmi Kannan, Xavier Llor, Nathan A. Ellis, Rosa M. Xicola, Adeyinka O. Laiyemo, John M. Carethers, Hassan Brim,  and Mehdi Nouraie
34546-34557
Abstract  |  PDF  |  HTML  |  Order a Reprint

iCar-PseCp: identify carbonylation sites in proteins by Monte Carlo sampling and incorporating sequence coupled effects into general PseAAC

iCar-PseCp: identify carbonylation sites in proteins by Monte Carlo sampling and incorporating sequence coupled effects into general PseAAC

https://doi.org/10.18632/oncotarget.9148

Jianhua Jia, Zi Liu, Xuan Xiao, Bingxiang Liu,  and Kuo-Chen Chou
34558-34570
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Downregulation and pro-apoptotic effect of hypoxia-inducible factor 2 alpha in hepatocellular carcinoma

Downregulation and pro-apoptotic effect of hypoxia-inducible factor 2 alpha in hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.8952

Sheng-li Yang, Li-ping Liu, Leilei Niu, Yun-fan Sun, Xing-rong Yang, Jia Fan, Jian-wei Ren, George G. Chen,  and Paul B.S. Lai
34571-34581
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A role for multiple chimeric antigen receptor-expressing leukocytes in antigen-specific responses to cancer

A role for multiple chimeric antigen receptor-expressing leukocytes in antigen-specific responses to cancer

https://doi.org/10.18632/oncotarget.9149

Carmen S.M. Yong, Liza B. John, Christel Devaud, Miles H. Prince, Ricky W. Johnstone, Joseph A. Trapani, Phillip K. Darcy,  and Michael H. Kershaw
34582-34598
Abstract  |  PDF  |  HTML  |  Order a Reprint

Synonymous mutations in oncogenesis and apoptosis versus survival unveiled by network modeling

Synonymous mutations in oncogenesis and apoptosis versus survival unveiled by network modeling

https://doi.org/10.18632/oncotarget.8963

Xiang Li, Yuan Chen, Hong Qi, Liyu Liu,  and Jianwei Shuai
34599-34616
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

FXR agonists enhance the sensitivity of biliary tract cancer cells to cisplatin via SHP dependent inhibition of Bcl-xL expression

FXR agonists enhance the sensitivity of biliary tract cancer cells to cisplatin via SHP dependent inhibition of Bcl-xL expression

https://doi.org/10.18632/oncotarget.8964

Wei Wang, Ming Zhan, Qi Li, Wei Chen, Huiling Chu, Qihong Huang, Zhaoyuan Hou, Mohan Man,  and Jian Wang
34617-34629
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

S100A4 drives non-small cell lung cancer invasion, associates with poor prognosis, and is effectively targeted by the FDA-approved anti-helminthic agent niclosamide

S100A4 drives non-small cell lung cancer invasion, associates with poor prognosis, and is effectively targeted by the FDA-approved anti-helminthic agent niclosamide

https://doi.org/10.18632/oncotarget.8969

Rachel L. Stewart, Brittany L. Carpenter, Dava S. West, Teresa Knifley, Lili Liu, Chi Wang, Heidi L. Weiss, Tamas S. Gal, Eric B. Durbin, Susanne M. Arnold, Kathleen L. O'Connor,  and Min Chen
34630-34642
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Impact of suppression of tumorigenicity 14 (ST14)/serine protease 14 (Prss14) expression analysis on the prognosis and management of estrogen receptor negative breast cancer

Impact of suppression of tumorigenicity 14 (ST14)/serine protease 14 (Prss14) expression analysis on the prognosis and management of estrogen receptor negative breast cancer

https://doi.org/10.18632/oncotarget.9155

Sauryang Kim, Jae Woong Yang, Chungho Kim,  and Moon Gyo Kim
34643-34663
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Characterization of preneoplastic and neoplastic rat mesothelial cell lines: the involvement of TETs, DNMTs, and 5-hydroxymethylcytosine

Characterization of preneoplastic and neoplastic rat mesothelial cell lines: the involvement of TETs, DNMTs, and 5-hydroxymethylcytosine

https://doi.org/10.18632/oncotarget.8970

David Roulois, Sophie Deshayes, Marie-Noëlle Guilly, Joëlle S. Nader, Charly Liddell, Myriam Robard, Philippe Hulin, Amal Ouacher, Vanessa Le Martelot, Jean-François Fonteneau, Marc Grégoire, Christophe Blanquart,  and Daniel L. Pouliquen
34664-34687
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Targeting radioresistant breast cancer cells by single agent CHK1 inhibitor via enhancing replication stress

Targeting radioresistant breast cancer cells by single agent CHK1 inhibitor via enhancing replication stress

https://doi.org/10.18632/oncotarget.9156

Yao Zhang, Jinzhi Lai, Zhanwen Du, Jinnan Gao, Shuming Yang, Shashank Gorityala, Xiahui Xiong, Ou Deng, Zhefu Ma, Chunhong Yan, Gonzalo Susana, Yan Xu,  and Junran Zhang
34688-34702
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Management of hepatocellular carcinoma: an overview of major findings from meta-analyses

Management of hepatocellular carcinoma: an overview of major findings from meta-analyses

https://doi.org/10.18632/oncotarget.9157

Xingshun Qi, Yan Zhao, Hongyu Li, Xiaozhong Guo,  and Guohong Han
34703-34751
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Coexistence of YWHAZ amplification predicts better prognosis in muscle-invasive bladder cancer with CDKN2A or TP53 loss

Coexistence of YWHAZ amplification predicts better prognosis in muscle-invasive bladder cancer with CDKN2A or TP53 loss

https://doi.org/10.18632/oncotarget.9158

Shenghua Liu, Yishuo Wu, Tian Yang, Chenchen Feng,  and Haowen Jiang
34752-34758
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Ubiquitin specific protease 19 involved in transcriptional repression of retinoic acid receptor by stabilizing CORO2A

Ubiquitin specific protease 19 involved in transcriptional repression of retinoic acid receptor by stabilizing CORO2A

https://doi.org/10.18632/oncotarget.8976

Key-Hwan Lim, Jong-Ho Choi, Jung-Hyun Park, Hyeon-Ju Cho, Jang-Joon Park, Eung-Ji Lee, Lan Li, Young-Kil Choi,  and Kwang-Hyun Baek
34759-34772
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

FOXO3a promotes gastric cancer cell migration and invasion through the induction of cathepsin L

FOXO3a promotes gastric cancer cell migration and invasion through the induction of cathepsin L

https://doi.org/10.18632/oncotarget.8977

Shan Yu, Yiyi Yu, Wen Zhang, Wei Yuan, Naiqing Zhao, Qian Li, Yuehong Cui, Yan Wang, Wei Li, Yihong Sun,  and Tianshu Liu
34773-34784
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Inhibition of CHK1 enhances cell death induced by the Bcl-2-selective inhibitor ABT-199 in acute myeloid leukemia cells

Inhibition of CHK1 enhances cell death induced by the Bcl-2-selective inhibitor ABT-199 in acute myeloid leukemia cells

https://doi.org/10.18632/oncotarget.9185

Jianyun Zhao, Xiaojia Niu, Xinyu Li, Holly Edwards, Guan Wang, Yue Wang, Jeffrey W Taub, Hai Lin,  and Yubin Ge
34785-34799
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

N-n-butyl haloperidol iodide ameliorates hypoxia/reoxygenation injury through modulating the LKB1/AMPK/ROS pathway in cardiac microvascular endothelial cells

N-n-butyl haloperidol iodide ameliorates hypoxia/reoxygenation injury through modulating the LKB1/AMPK/ROS pathway in cardiac microvascular endothelial cells

https://doi.org/10.18632/oncotarget.9186

Binger Lu, Bin Wang, Shuping Zhong, Yanmei Zhang, Fenfei Gao, Yicun Chen, Fuchun Zheng,  and Ganggang Shi
34800-34810
Abstract  |  PDF  |  HTML  |  Order a Reprint

Serum VEGF-A and CCL5 levels as candidate biomarkers for efficacy and toxicity of regorafenib in patients with metastatic colorectal cancer

Serum VEGF-A and CCL5 levels as candidate biomarkers for efficacy and toxicity of regorafenib in patients with metastatic colorectal cancer

https://doi.org/10.18632/oncotarget.9187

Mitsukuni Suenaga, Tetsuo Mashima, Naomi Kawata, Takeru Wakatsuki, Yuki Horiike, Satoshi Matsusaka, Shingo Dan, Eiji Shinozaki, Hiroyuki Seimiya, Nobuyuki Mizunuma, Kensei Yamaguchi,  and Toshiharu Yamaguchi
34811-34823
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Comparative effectiveness and safety between oxaliplatin-based and cisplatin-based therapy in advanced gastric cancer: A meta-analysis of randomized controlled trials

Comparative effectiveness and safety between oxaliplatin-based and cisplatin-based therapy in advanced gastric cancer: A meta-analysis of randomized controlled trials

https://doi.org/10.18632/oncotarget.9189

Jun Huang, Yongzhao Zhao, Yong Xu, Yanjie Zhu, Jiale Huang, Yanna Liu, Liying Zhao, Zhijia Li, Hao Liu, Qi-long Wang,  and Xiaolong Qi
34824-34831
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Metformin blocks progression of obesity-activated thyroid cancer in a mouse model

Metformin blocks progression of obesity-activated thyroid cancer in a mouse model

https://doi.org/10.18632/oncotarget.8989

Jeongwon Park, Won Gu Kim, Li Zhao, Keisuke Enomoto, Mark Willingham,  and Sheue-Yann Cheng
34832-34844
Abstract  |  PDF  |  HTML  |  Order a Reprint

MECP2 promotes the growth of gastric cancer cells by suppressing miR-338-mediated antiproliferative effect

MECP2 promotes the growth of gastric cancer cells by suppressing miR-338-mediated antiproliferative effect

https://doi.org/10.18632/oncotarget.9197

Dongdong Tong, Lingyu Zhao, Kang He, Hongfei Sun, Donghui Cai, Lei Ni, Ruifang Sun, Su’e Chang, Tusheng Song,  and Chen Huang
34845-34859
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Trk inhibition reduces cell proliferation and potentiates the effects of chemotherapeutic agents in Ewing sarcoma

Trk inhibition reduces cell proliferation and potentiates the effects of chemotherapeutic agents in Ewing sarcoma

https://doi.org/10.18632/oncotarget.8992

Tiago Elias Heinen, Rafael Pereira dos Santos, Amanda da Rocha, Michel Pinheiro do Santos, Patrícia Luciana da Costa Lopez, Marco Aurélio Silva Filho, Bárbara Kunzler Souza, Luís Fernando da Rosa Rivero, Ricardo Gehrke Becker, Lauro José Gregianin, Algemir Lunardi Brunetto, André Tesainer Brunetto, Caroline Brunetto de Farias,  and Rafael Roesler
34860-34880
Abstract  |  PDF  |  HTML  |  Order a Reprint

The prognostic and predictive value of the lymphocyte to monocyte ratio in luminal-type breast cancer patients treated with CEF chemotherapy

The prognostic and predictive value of the lymphocyte to monocyte ratio in luminal-type breast cancer patients treated with CEF chemotherapy

https://doi.org/10.18632/oncotarget.8993

Hongfei Ji, Qijia Xuan, Caichuan Yan, Tao Liu, Abiyasi Nanding,  and Qingyuan Zhang
34881-34889
Abstract  |  PDF  |  HTML  |  Order a Reprint

SOX2 functions as a molecular rheostat to control the growth, tumorigenicity and drug responses of pancreatic ductal adenocarcinoma cells

SOX2 functions as a molecular rheostat to control the growth, tumorigenicity and drug responses of pancreatic ductal adenocarcinoma cells

https://doi.org/10.18632/oncotarget.8994

Erin L. Wuebben, Phillip J. Wilder, Jesse L. Cox, James A. Grunkemeyer, Thomas Caffrey, Michael A. Hollingsworth,  and Angie Rizzino
34890-34906
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Systemic release of osteoprotegerin during oxaliplatin-containing induction chemotherapy and favorable systemic outcome of sequential radiotherapy in rectal cancer

Systemic release of osteoprotegerin during oxaliplatin-containing induction chemotherapy and favorable systemic outcome of sequential radiotherapy in rectal cancer

https://doi.org/10.18632/oncotarget.8995

Sebastian Meltzer, Erta Kalanxhi, Helga Helseth Hektoen, Svein Dueland, Kjersti Flatmark, Kathrine Røe Redalen,  and Anne Hansen Ree
34907-34917
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Quantitative assessment of preoperative serum thyrotropin level and thyroid cancer

Quantitative assessment of preoperative serum thyrotropin level and thyroid cancer

https://doi.org/10.18632/oncotarget.9201

Jiaojiao Zheng, Chen Li, Weihui Lu, Cong Wang,  and Zhilong Ai
34918-34929
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Heterogeneous PSMA expression on circulating tumor cells - a potential basis for stratification and monitoring of PSMA-directed therapies in prostate cancer

Heterogeneous PSMA expression on circulating tumor cells - a potential basis for stratification and monitoring of PSMA-directed therapies in prostate cancer

https://doi.org/10.18632/oncotarget.9004

Tobias M. Gorges, Sabine Riethdorf, Oliver von Ahsen, Paulina Nastały, Katharina Röck, Marcel Boede, Sven Peine, Andra Kuske, Elke Schmid, Christoph Kneip, Frank König, Marion Rudolph,  and Klaus Pantel
34930-34941
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Mutant IDH1 expression is associated with down-regulation of monocarboxylate transporters

Mutant IDH1 expression is associated with down-regulation of monocarboxylate transporters

https://doi.org/10.18632/oncotarget.9006

Pavithra Viswanath, Chloe Najac, Jose L. Izquierdo-Garcia, Aleksandr Pankov, Chibo Hong, Pia Eriksson, Joseph F. Costello, Russell O. Pieper,  and Sabrina M. Ronen
34942-34955
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Identification of genes that are essential to restrict genome duplication to once per cell division

Identification of genes that are essential to restrict genome duplication to once per cell division

https://doi.org/10.18632/oncotarget.9008

Alex Vassilev, Chrissie Y. Lee, Boris Vassilev, Wenge Zhu, Pinar Ormanoglu, Scott E. Martin,  and Melvin L. DePamphilis
34956-34976
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Overexpression of ankyrin1 promotes pancreatic cancer cell growth

Overexpression of ankyrin1 promotes pancreatic cancer cell growth

https://doi.org/10.18632/oncotarget.9009

Noriyuki Omura, Masamichi Mizuma, Anne MacGregor, Seung-Mo Hong, Michael Ayars, Jose Alejandro Almario, Michael Borges, Mitsuro Kanda, Ang Li, Audrey Vincent, Anirban Maitra,  and Michael Goggins
34977-34987
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Next-generation proteasome inhibitor oprozomib synergizes with modulators of the unfolded protein response to suppress hepatocellular carcinoma

Next-generation proteasome inhibitor oprozomib synergizes with modulators of the unfolded protein response to suppress hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.9222

Yves-Paul Vandewynckel, Céline Coucke, Debby Laukens, Lindsey Devisscher, Annelies Paridaens, Eliene Bogaerts, Astrid Vandierendonck, Sarah Raevens, Xavier Verhelst, Christophe Van Steenkiste, Louis Libbrecht, Anja Geerts,  and Hans Van Vlierberghe
34988-35000
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A natural small molecule, catechol, induces c-Myc degradation by directly targeting ERK2 in lung cancer

A natural small molecule, catechol, induces c-Myc degradation by directly targeting ERK2 in lung cancer

https://doi.org/10.18632/oncotarget.9223

Do Young Lim, Seung Ho Shin, Mee-Hyun Lee, Margarita Malakhova, Igor Kurinov, Qiong Wu, Jinglong Xu, Yanan Jiang, Ziming Dong, Kangdong Liu, Kun Yeong Lee, Ki Beom Bae, Bu Young Choi, Yibin Deng, Ann Bode,  and Zigang Dong
35001-35014
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Significance of microRNA-related variants in susceptibility to recurrence of oropharyngeal cancer patients after definitive radiotherapy

Significance of microRNA-related variants in susceptibility to recurrence of oropharyngeal cancer patients after definitive radiotherapy

https://doi.org/10.18632/oncotarget.9014

Xingming Chen, Erich M. Sturgis, Chengyuan Wang, Xiaoli Cao, Yuncheng Li, Qingyi Wei,  and Guojun Li
35015-35025
Abstract  |  PDF  |  HTML  |  Order a Reprint

microRNA-802/Rnd3 pathway imposes on carcinogenesis and metastasis of fine particulate matter exposure

microRNA-802/Rnd3 pathway imposes on carcinogenesis and metastasis of fine particulate matter exposure

https://doi.org/10.18632/oncotarget.9019

Xiaobo Li, Yang Lv, Na Gao, Hao Sun, Runze Lu, Hongbao Yang, Chengcheng Zhang, Qingtao Meng, Shenshen Wu, Ai-Qun Li, Yankai Xia,  and Rui Chen
35026-35043
Abstract  |  PDF  |  HTML  |  Order a Reprint

Integrative analysis reveals clinical phenotypes and oncogenic potentials of long non-coding RNAs across 15 cancer types

Integrative analysis reveals clinical phenotypes and oncogenic potentials of long non-coding RNAs across 15 cancer types

https://doi.org/10.18632/oncotarget.9037

Ze-Lin Wang, Bin Li, Stephen R. Piccolo, Xiao-Qin Zhang, Jun-Hao Li, Hui Zhou, Jian-Hua Yang,  and Liang-Hu Qu
35044-35055
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

BIS-mediated STAT3 stabilization regulates glioblastoma stem cell-like phenotypes

BIS-mediated STAT3 stabilization regulates glioblastoma stem cell-like phenotypes

https://doi.org/10.18632/oncotarget.9039

Chang-Nim Im, Hye Hyeon Yun, Byunghoo Song, Dong-Ye Youn, Mei Nu Cui, Hong Sug Kim, Gyeong Sin Park,  and Jeong-Hwa Lee
35056-35070
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Prognostic factors in patients with recurrent hepatocellular carcinoma treated with salvage liver transplantation: a single-center study

Prognostic factors in patients with recurrent hepatocellular carcinoma treated with salvage liver transplantation: a single-center study

https://doi.org/10.18632/oncotarget.9040

Pusen Wang, Hao Li, Baojie Shi, Weitao Que, Chunguang Wang, Junwei Fan, Zhihai Peng,  and Lin Zhong
35071-35083
Abstract  |  PDF  |  HTML  |  Order a Reprint

Increased number of negative lymph nodes is associated with improved survival outcome in node positive gastric cancer following radical gastrectomy

Increased number of negative lymph nodes is associated with improved survival outcome in node positive gastric cancer following radical gastrectomy

https://doi.org/10.18632/oncotarget.9041

Rong-liang Shi, Qian Chen, Jun Bing Ding, Zhen Yang, Gaofeng Pan, Daowen Jiang,  and Weiyan Liu
35084-35091
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Downregulation of miR-199b is associated with distant metastasis in colorectal cancer via activation of SIRT1 and inhibition of CREB/KISS1 signaling

Downregulation of miR-199b is associated with distant metastasis in colorectal cancer via activation of SIRT1 and inhibition of CREB/KISS1 signaling

https://doi.org/10.18632/oncotarget.9042

Zhan-long Shen, Bo Wang, Ke-wei Jiang, Chun-xiang Ye, Cheng Cheng, Yi-chao Yan, Ji-zhun Zhang, Yang Yang, Zhi-dong Gao, Ying-jiang Ye,  and Shan Wang
35092-35105
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Assessment of epigenetic alterations in early colorectal lesions containing BRAF mutations

Assessment of epigenetic alterations in early colorectal lesions containing BRAF mutations

https://doi.org/10.18632/oncotarget.9044

Takeshi Sawada, Eiichiro Yamamoto, Hiro-o Yamano, Masanori Nojima, Taku Harada, Reo Maruyama, Masami Ashida, Hironori Aoki, Hiro-o Matsushita, Kenjiro Yoshikawa, Eiji Harada, Yoshihito Tanaka, Shigenori Wakita, Takeshi Niinuma, Masahiro Kai, Makoto Eizuka, Tamotsu Sugai,  and Hiromu Suzuki
35106-35118
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

JNK2 downregulation promotes tumorigenesis and chemoresistance by decreasing p53 stability in bladder cancer

JNK2 downregulation promotes tumorigenesis and chemoresistance by decreasing p53 stability in bladder cancer

https://doi.org/10.18632/oncotarget.9046

Chun-Wu Pan, Hailong Liu, Yu Zhao, Chenchen Qian, Liguo Wang,  and Jun Qi
35119-35131
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Continuous anti-angiogenic therapy after tumor progression in patients with recurrent high-grade epithelial ovarian cancer: phase I trial experience

Continuous anti-angiogenic therapy after tumor progression in patients with recurrent high-grade epithelial ovarian cancer: phase I trial experience

https://doi.org/10.18632/oncotarget.9048

Ming-Mo Hou, Zhijie Wang, Filip Janku, Sarina Piha-Paul, Aung Naing, David Hong, Shannon Westin, Robert L. Coleman, Anil K. Sood, Apostolia M. Tsimberidou, Vivek Subbiah, Jennifer Wheler, Ralph Zinner, Karen Lu, Funda Meric-Bernstam,  and Siqing Fu
35132-35143
Abstract  |  PDF  |  HTML  |  Order a Reprint

Prevention effect of rare ginsenosides against stress-hormone induced MTOC amplification

Prevention effect of rare ginsenosides against stress-hormone induced MTOC amplification

https://doi.org/10.18632/oncotarget.9059

Jung-Hyun Cho, Ho-Young Chun, Jung Suk Lee, Jee-Hyun Lee, Kyu Jin Cheong, Youn-Sang Jung, Tae-Gyun Woo, Min-Ho Yoon, Ah-Young Oh, So-Mi Kang, Chunghui Lee, Hokeun Sun, Jihwan Hwang, Gyu-Yong Song,  and Bum-Joon Park
35144-35158
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

ERCC1 expression affects outcome in metastatic pancreatic carcinoma treated with FOLFIRINOX: A single institution analysis

ERCC1 expression affects outcome in metastatic pancreatic carcinoma treated with FOLFIRINOX: A single institution analysis

https://doi.org/10.18632/oncotarget.9063

Antonia Strippoli, Sabrina Rossi, Maurizio Martini, Michele Basso, Ettore D'Argento, Giovanni Schinzari, Rosalba Barile, Alessandra Cassano,  and Carlo Barone
35159-35168
Abstract  |  PDF  |  HTML  |  Order a Reprint

Solid tumors provide niche-specific conditions that lead to preferential growth of Salmonella

Solid tumors provide niche-specific conditions that lead to preferential growth of Salmonella

https://doi.org/10.18632/oncotarget.9071

Cecilia A. Silva-Valenzuela, Prerak T. Desai, Roberto C. Molina-Quiroz, David Pezoa, Yong Zhang, Steffen Porwollik, Ming Zhao, Robert M. Hoffman, Inés Contreras, Carlos A. Santiviago,  and Michael McClelland
35169-35180
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Metastatic renal cell carcinoma: the first report of unilateral fundus hemorrhage induced by sorafenib

Metastatic renal cell carcinoma: the first report of unilateral fundus hemorrhage induced by sorafenib

https://doi.org/10.18632/oncotarget.9285

Zhi Yong Li, Xin Xiang Fan, Yan Jun Wang, Kai Yao, Zhuo Wei Liu, Wen Tao Pan, Yun Lin Ye, Ping Yang, Yi Chuan Huang, Zhi Ming Wu,  and Fang Jian Zhou
35181-35187
Abstract  |  PDF  |  HTML  |  Order a Reprint

mir-101-3p is a key regulator of tumor metabolism in triple negative breast cancer targeting AMPK

mir-101-3p is a key regulator of tumor metabolism in triple negative breast cancer targeting AMPK

https://doi.org/10.18632/oncotarget.9072

Peng Liu, Feng Ye, Xinhua Xie, Xing Li, Hailin Tang, Shuaijie Li, Xiaojia Huang, Cailu Song, Weidong Wei,  and Xiaoming Xie
35188-35198
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Identification of a functional variant for colorectal cancer risk mapping to chromosome 5q31.1

Identification of a functional variant for colorectal cancer risk mapping to chromosome 5q31.1

https://doi.org/10.18632/oncotarget.9298

Juntao Ke, Jiao Lou, Xueqin Chen, Jiaoyuan Li, Cheng Liu, Yajie Gong, Yang Yang, Ying Zhu, Yi Zhang, Jianbo Tian, Jiang Chang, Rong Zhong, Jing Gong,  and Xiaoping Miao
35199-35207
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Nobiletin inhibits human osteosarcoma cells metastasis by blocking ERK and JNK-mediated MMPs expression

Nobiletin inhibits human osteosarcoma cells metastasis by blocking ERK and JNK-mediated MMPs expression

https://doi.org/10.18632/oncotarget.9106

Hsin-Lin Cheng, Ming-Ju Hsieh, Jia-Sin Yang, Chiao-Wen Lin, Ko-Haung Lue, Ko-Hsiu Lu,  and Shun-Fa Yang
35208-35223
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Androgen suppresses testicular cancer cell growth in vitro and in vivo

Androgen suppresses testicular cancer cell growth in vitro and in vivo

https://doi.org/10.18632/oncotarget.9109

Hideo Nakagawa, Takashi Ueda, Saya Ito, Takumi Shiraishi, Hidefumi Taniguchi, Naruhiro Kayukawa, Hiroyuki Nakanishi, So Ushijima, Motohiro Kanazawa, Terukazu Nakamura, Yoshio Naya, Fumiya Hongo, Kazumi Kamoi, Koji Okihara,  and Osamu Ukimura
35224-35232
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Predictive value of APAF-1 and COX-2 expression in pathologic complete response to neoadjuvant chemoradiotherapy for patients with locally advanced rectal adenocarcinoma

Predictive value of APAF-1 and COX-2 expression in pathologic complete response to neoadjuvant chemoradiotherapy for patients with locally advanced rectal adenocarcinoma

https://doi.org/10.18632/oncotarget.9125

Haihua Peng, Kaiyun You, Rong Zhang, Shaoyan Xi, Tian Zhang, Jun Dong, Muyan Cai, Chengtao Wang, Huizhong Zhang, Tongchong Zhou, Yuanhong Gao,  and Bixiu Wen
35233-35240
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Cell cycle progression score is a marker for five-year lung cancer-specific mortality risk in patients with resected stage I lung adenocarcinoma

Cell cycle progression score is a marker for five-year lung cancer-specific mortality risk in patients with resected stage I lung adenocarcinoma

https://doi.org/10.18632/oncotarget.9129

Takashi Eguchi, Kyuichi Kadota, Jamie Chaft, Brent Evans, John Kidd, Kay See Tan, Joe Dycoco, Kathryn Kolquist, Thaylon Davis, Stephanie A. Hamilton, Kraig Yager, Joshua T. Jones, William D. Travis, David R. Jones, Anne-Renee Hartman,  and Prasad S. Adusumilli
35241-35256
Abstract  |  PDF  |  HTML  |  Order a Reprint

miR-592/WSB1/HIF-1α axis inhibits glycolytic metabolism to decrease hepatocellular carcinoma growth

miR-592/WSB1/HIF-1α axis inhibits glycolytic metabolism to decrease hepatocellular carcinoma growth

https://doi.org/10.18632/oncotarget.9135

Yan-Yan Jia, Jin-Yi Zhao, Bing-Ling Li, Kai Gao, Ying Song, Mei-You Liu, Xiao-Juan Yang, Yan Xue, Ai-Dong Wen,  and Lei Shi
35257-35269
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Upregulation of lactate dehydrogenase a by 14-3-3ζ leads to increased glycolysis critical for breast cancer initiation and progression

Upregulation of lactate dehydrogenase a by 14-3-3ζ leads to increased glycolysis critical for breast cancer initiation and progression

https://doi.org/10.18632/oncotarget.9136

Chia-Chi Chang, Chenyu Zhang, Qingling Zhang, Ozgur Sahin, Hai Wang, Jia Xu, Yi Xiao, Jian Zhang, Sumaiyah K. Rehman, Ping Li, Mien-Chie Hung, Fariba Behbod,  and Dihua Yu
35270-35283
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

miR-363 promotes proliferation and chemo-resistance of human gastric cancer via targeting of FBW7 ubiquitin ligase expression

miR-363 promotes proliferation and chemo-resistance of human gastric cancer via targeting of FBW7 ubiquitin ligase expression

https://doi.org/10.18632/oncotarget.9169

Peng-Fei Zhang, Lu-Lu Sheng, Ge Wang, Mi Tian, Ling-Yin Zhu, Rui Zhang, Jing Zhang,  and Jin-Shui Zhu
35284-35292
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Leukemic stem cell persistence in chronic myeloid leukemia patients in deep molecular response induced by tyrosine kinase inhibitors and the impact of therapy discontinuation

Leukemic stem cell persistence in chronic myeloid leukemia patients in deep molecular response induced by tyrosine kinase inhibitors and the impact of therapy discontinuation

https://doi.org/10.18632/oncotarget.9182

Jean Claude Chomel, Marie Laure Bonnet, Nathalie Sorel, Ivan Sloma, Annelise Bennaceur-Griscelli, Delphine Rea, Laurence Legros, Anne Marfaing-Koka, Jean-Henri Bourhis, Shanti Ame, Agnès Guerci-Bresler, Philippe Rousselot,  and Ali G. Turhan
35293-35301
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

RNA sequencing-based analysis of gallbladder cancer reveals the importance of the liver X receptor and lipid metabolism in gallbladder cancer

RNA sequencing-based analysis of gallbladder cancer reveals the importance of the liver X receptor and lipid metabolism in gallbladder cancer

https://doi.org/10.18632/oncotarget.9181

Mingxin Zuo, Asif Rashid, Ying Wang, Apurva Jain, Donghui Li, Anu Behari, Vinay Kumar Kapoor, Eugene J. Koay, Ping Chang, Jean Nicholas Vauthey, Yanan Li, Jaime A. Espinoza, Juan Carlos Roa,  and Milind Javle
35302-35312
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Reduction in promotor methylation utilizing EGCG (epigallocatechin-3-gallate) restores RXRα expression in human colon cancer cells

Reduction in promotor methylation utilizing EGCG (epigallocatechin-3-gallate) restores RXRα expression in human colon cancer cells

https://doi.org/10.18632/oncotarget.9204

Jay Morris, Vondina R. Moseley, April B. Cabang, Katie Coleman, Wei Wei, Elizabeth Garrett-Mayer,  and Michael J. Wargovich
35313-35326
Abstract  |  PDF  |  HTML  |  Order a Reprint

Zinc- and bicarbonate-dependent ZIP8 transporter mediates selenite uptake

Zinc- and bicarbonate-dependent ZIP8 transporter mediates selenite uptake

https://doi.org/10.18632/oncotarget.9205

Joseph R. McDermott, Xiangrong Geng, Lan Jiang, Marina Gálvez-Peralta, Fei Chen, Daniel W. Nebert,  and Zijuan Liu
35327-35340
Abstract  |  PDF  |  HTML  |  Order a Reprint

The IRX1/HOXA connection: insights into a novel t(4;11)- specific cancer mechanism

The IRX1/HOXA connection: insights into a novel t(4;11)- specific cancer mechanism

https://doi.org/10.18632/oncotarget.9241

Alessa Kühn, Denise Löscher,  and Rolf Marschalek
35341-35352
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Monomeric gremlin is a novel vascular endothelial growth factor receptor-2 antagonist

Monomeric gremlin is a novel vascular endothelial growth factor receptor-2 antagonist

https://doi.org/10.18632/oncotarget.9286

Elisabetta Grillo, Cosetta Ravelli, Michela Corsini, Kurt Ballmer-Hofer, Luca Zammataro, Pasqua Oreste, Giorgio Zoppetti, Chiara Tobia, Roberto Ronca, Marco Presta,  and Stefania Mitola
35353-35368
Abstract  |  PDF  |  HTML  |  Order a Reprint

Prognostic value of microRNAs in cervical carcinoma: a systematic review and meta-analysis

Prognostic value of microRNAs in cervical carcinoma: a systematic review and meta-analysis

https://doi.org/10.18632/oncotarget.9294

Shengkang Dai, Yan Lu, Ying Long, Yuehua Lai, Ping Du, Nan Ding,  and Desheng Yao
35369-35378
Abstract  |  PDF  |  HTML  |  Order a Reprint

Characterization of the novel indolylmaleimides’ PDA-66 and PDA-377 effect on canine lymphoma cells

Characterization of the novel indolylmaleimides’ PDA-66 and PDA-377 effect on canine lymphoma cells

https://doi.org/10.18632/oncotarget.9297

Wen Liu, Julia Beck, Laura C. Schmidt, Catrin Roolf, Anahit Pews-Davtyan, Barbara C. Rütgen, Sabine Hammer, Saskia Willenbrock, Anett Sekora, Arndt Rolfs, Matthias Beller, Bertram Brenig, Ingo Nolte, Christian Junghanss, Ekkehard Schütz,  and Hugo Murua Escobar
35379-35389
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Ginsenoside Rg1 and platelet-rich fibrin enhance human breast adipose-derived stem cells function for soft tissue regeneration

Ginsenoside Rg1 and platelet-rich fibrin enhance human breast adipose-derived stem cells function for soft tissue regeneration

https://doi.org/10.18632/oncotarget.9360

Fang-Tian Xu, Zhi-Jie Liang, Hong-Mian Li, Qi-Liu Peng, Min-Hong Huang, De-Quan Li, Yi-Dan Liang, Gang-Yi Chi, De-Hui Li, Bing-Chao Yu,  and Ji-Rong Huang
35390-35403
Abstract  |  PDF  |  HTML  |  Order a Reprint

Clinical Research Papers

High risk of deep vein thrombosis associated with peripherally inserted central catheters in lymphoma

High risk of deep vein thrombosis associated with peripherally inserted central catheters in lymphoma

https://doi.org/10.18632/oncotarget.8639

Xi Zhang, Jia-Jia Huang, Yi Xia, Chao-Feng Li, Yu Wang, Pan-Pan Liu, Xi-Wen Bi, Peng Sun, Tong-Yu Lin, Wen-Qi Jiang,  and Zhi-Ming Li
35404-35411
Abstract  |  PDF  |  HTML  |  Order a Reprint

Analysis of the efficacy and safety of a combined gemcitabine, oxaliplatin and pegaspargase regimen for NK/T-cell lymphoma

Analysis of the efficacy and safety of a combined gemcitabine, oxaliplatin and pegaspargase regimen for NK/T-cell lymphoma

https://doi.org/10.18632/oncotarget.8643

Jing-hua Wang, Hua Wang, Yan-jun Wang, Zhong-jun Xia, Hui-qiang Huang, Wen-qi Jiang,  and Yue Lu
35412-35422
Abstract  |  PDF  |  HTML  |  Order a Reprint

Prognostic significance of preoperative serum CA125, CA19-9 and CEA in gastric carcinoma

Prognostic significance of preoperative serum CA125, CA19-9 and CEA in gastric carcinoma

https://doi.org/10.18632/oncotarget.8770

Wei Wang, Xiao-Long Chen, Shen-Yu Zhao, Yu-Hui Xu, Wei-Han Zhang, Kai Liu, Xin-Zu Chen, Kun Yang, Bo Zhang, Zhi-Xin Chen, Jia-Ping Chen, Zong-Guang Zhou,  and Jian-Kun Hu
35423-35436
Abstract  |  PDF  |  HTML  |  Order a Reprint

Metformin therapy associated with survival benefit in lung cancer patients with diabetes

Metformin therapy associated with survival benefit in lung cancer patients with diabetes

https://doi.org/10.18632/oncotarget.8881

Guoxing Wan, Xiongjie Yu, Ping Chen, Xianhe Wang, Dongfeng Pan, Xuanbin Wang, Linjun Li, Xiaojun Cai,  and Fengjun Cao
35437-35445
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Combined preoperative concentrations of CEA, CA 19-9, and 72-4 for predicting outcomes in patients with gastric cancer after curative resection

Combined preoperative concentrations of CEA, CA 19-9, and 72-4 for predicting outcomes in patients with gastric cancer after curative resection

https://doi.org/10.18632/oncotarget.9060

Xuechao Liu, Haibo Qiu, Jianjun Liu, Shangxiang Chen, Dazhi Xu, Wei Li, Youqing Zhan, Yuanfang Li, Yingbo Chen, Zhiwei Zhou,  and Xiaowei Sun
35446-35453
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Reviews

Control of CREB expression in tumors: from molecular mechanisms and signal transduction pathways to therapeutic target

Control of CREB expression in tumors: from molecular mechanisms and signal transduction pathways to therapeutic target

https://doi.org/10.18632/oncotarget.7721

André Steven,  and Barbara Seliger
35454-35465
Abstract  |  PDF  |  HTML  |  Order a Reprint

Multiple myeloma cancer stem cells

Multiple myeloma cancer stem cells

https://doi.org/10.18632/oncotarget.8154

Minjie Gao, Yuanyuan Kong, Guang Yang, Lu Gao,  and Jumei Shi
35466-35477
Abstract  |  PDF  |  HTML  |  Order a Reprint

Hallmarks of glycosylation in cancer

Hallmarks of glycosylation in cancer

https://doi.org/10.18632/oncotarget.8155

Jennifer Munkley,  and David J. Elliott
35478-35489
Abstract  |  PDF  |  HTML  |  Order a Reprint

Interplay between myeloid-derived suppressor cells (MDSCs) and Th17 cells: foe or friend?

Interplay between myeloid-derived suppressor cells (MDSCs) and Th17 cells: foe or friend?

https://doi.org/10.18632/oncotarget.8204

Liang Wen, Ping Gong, Chao Liang, Dawei Shou, Baoqing Liu, Yiwen Chen, Changqian Bao, Li Chen, Xiaowei Liu, Tingbo Liang,  and Weihua Gong
35490-35496
Abstract  |  PDF  |  HTML  |  Order a Reprint

Corrections

Correction: Molecular profiling of cetuximab and bevacizumab treatment of colorectal tumours reveals perturbations in metabolic and hypoxic response pathways

Correction: Molecular profiling of cetuximab and bevacizumab treatment of colorectal tumours reveals perturbations in metabolic and hypoxic response pathways

https://doi.org/10.18632/oncotarget.9855

David W. Greening, Sze Ting Lee, Hong Ji, Richard J. Simpson, Angela Rigopoulos, Carmel Murone, Catherine Fang, Sylvia Gong, Graeme O’Keefe,  and Andrew M. Scott
35497
Correction  |  PDF


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