Oncotarget

Vol 7, No 20

May 17, 2016

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XAV939 induces YAP cytoplasmic relocalization. See Troilo, et al.

Table of Contents

Editorial: Autophagy and Cell Death

Turning off the BCL-2 switch to prevent intestinal tumorigenesis

Turning off the BCL-2 switch to prevent intestinal tumorigenesis

https://doi.org/10.18632/oncotarget.8757

Maartje van der Heijden, Douglas J. Winton,  and Louis Vermeulen
28763-28764
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Priority Research Papers

Angiomotin stabilization by tankyrase inhibitors antagonizes constitutive TEAD-dependent transcription and proliferation of human tumor cells with Hippo pathway core component mutations

Angiomotin stabilization by tankyrase inhibitors antagonizes constitutive TEAD-dependent transcription and proliferation of human tumor cells with Hippo pathway core component mutations

https://doi.org/10.18632/oncotarget.9117

Albino Troilo, Erica K. Benson, Davide Esposito, Rachel-Ann A. Garibsingh, E. Premkumar Reddy, Sathish Kumar Mungamuri,  and Stuart A. Aaronson
28765-28782
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Interview with Dr. Stuart A. Aaronson  |  Order a Reprint

Research Papers: Gerotarget (Focus on Aging)

Inflammatory and immune markers associated with physical frailty syndrome: findings from Singapore longitudinal aging studies

Inflammatory and immune markers associated with physical frailty syndrome: findings from Singapore longitudinal aging studies

https://doi.org/10.18632/oncotarget.8939

Yanxia Lu, Crystal Tze Ying Tan, Ma Shwe Zin Nyunt, Esther Wing Hei Mok, Xavier Camous, Hassen Kared, Tamas Fulop, Liang Feng, Tze Pin Ng,  and Anis Larbi
28783-28795
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Research Papers: Pathology

MicroRNA-93 inhibits ischemia-reperfusion induced cardiomyocyte apoptosis by targeting PTEN

MicroRNA-93 inhibits ischemia-reperfusion induced cardiomyocyte apoptosis by targeting PTEN

https://doi.org/10.18632/oncotarget.8941

Zun-Ping Ke, Peng Xu, Yan Shi,  and Ai-Mei Gao
28796-28805
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Research Papers: Immunology

Identification of the microRNA networks contributing to macrophage differentiation and function

Identification of the microRNA networks contributing to macrophage differentiation and function

https://doi.org/10.18632/oncotarget.8933

Hong Zhou, Jie Zhang, Fiona Eyers, Yang Xiang, Cristan Herbert, Hock, L. Tay, Paul S. Foster,  and Ming Yang
28806-28820
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Research Papers: Autophagy and Cell Death

Mitophagy acts as a safeguard mechanism against human vascular smooth muscle cell apoptosis induced by atherogenic lipids

Mitophagy acts as a safeguard mechanism against human vascular smooth muscle cell apoptosis induced by atherogenic lipids

https://doi.org/10.18632/oncotarget.8936

Audrey Swiader, Hripsime Nahapetyan, Julien Faccini, Romina D’Angelo, Elodie Mucher, Meyer Elbaz, Patricia Boya,  and Cécile Vindis
28821-28835
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Research Papers

Setdb1, a novel interactor of ΔNp63, is involved in breast tumorigenesis

Setdb1, a novel interactor of ΔNp63, is involved in breast tumorigenesis

https://doi.org/10.18632/oncotarget.7089

Carla Regina, Mirco Compagnone, Angelo Peschiaroli, AnnaMaria Lena, Margherita Annicchiarico-Petruzzelli, Maria Cristina Piro, Gerry Melino,  and Eleonora Candi
28836-28848
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The histone deacetylase inhibitor SAHA induces HSP60 nitration and its extracellular release by exosomal vesicles in human lung-derived carcinoma cells

The histone deacetylase inhibitor SAHA induces HSP60 nitration and its extracellular release by exosomal vesicles in human lung-derived carcinoma cells

https://doi.org/10.18632/oncotarget.6680

Claudia Campanella, Antonella D'Anneo, Antonella Marino Gammazza, Celeste Caruso Bavisotto, Rosario Barone, Sonia Emanuele, Filippa Lo Cascio, Emanuele Mocciaro, Stefano Fais, Everly Conway De Macario, Alberto J.L. Macario, Francesco Cappello,  and Marianna Lauricella
28849-28867
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Heme oxygenase-1 nuclear translocation regulates bortezomib-induced cytotoxicity and mediates genomic instability in myeloma cells

Heme oxygenase-1 nuclear translocation regulates bortezomib-induced cytotoxicity and mediates genomic instability in myeloma cells

https://doi.org/10.18632/oncotarget.7563

Daniele Tibullo, Ignazio Barbagallo, Cesarina Giallongo, Luca Vanella, Concetta Conticello, Alessandra Romano, Salvatore Saccone, Justyna Godos, Francesco Di Raimondo,  and Giovanni Li Volti
28868-28880
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Betacellulin induces Slug-mediated down-regulation of E-cadherin and cell migration in ovarian cancer cells

Betacellulin induces Slug-mediated down-regulation of E-cadherin and cell migration in ovarian cancer cells

https://doi.org/10.18632/oncotarget.7591

Jianfang Zhao, Christian Klausen, Xin Qiu, Jung-Chien Cheng, Hsun-Ming Chang,  and Peter C.K. Leung
28881-28890
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Brachyury as a potential modulator of androgen receptor activity and a key player in therapy resistance in prostate cancer

Brachyury as a potential modulator of androgen receptor activity and a key player in therapy resistance in prostate cancer

https://doi.org/10.18632/oncotarget.8499

Filipe Pinto, Nelma Pértega-Gomes, José R. Vizcaíno, Raquel P. Andrade, Flavio M. Cárcano,  and Rui Manuel Reis
28891-28902
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Increased liver carcinogenesis and enrichment of stem cell properties in livers of Dickkopf 2 (Dkk2) deleted mice

Increased liver carcinogenesis and enrichment of stem cell properties in livers of Dickkopf 2 (Dkk2) deleted mice

https://doi.org/10.18632/oncotarget.3293

Thorsten Maass, Jens Marquardt, Ju-Seog Lee, Markus Krupp, Peter Scholz-Kreisel, Carolin Mogler, Peter Schirmacher, Martina Müller, Heiner Westphal, Peter R. Galle,  and Andreas Teufel
28903-28913
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Mutations of SETBP1 and JAK3 in juvenile myelomonocytic leukemia: a report from the Italian AIEOP study group

Mutations of SETBP1 and JAK3 in juvenile myelomonocytic leukemia: a report from the Italian AIEOP study group

https://doi.org/10.18632/oncotarget.8016

Silvia Bresolin, Paola De Filippi, Francesca Vendemini, Mirko D’Alia, Marco Zecca, Lueder H. Meyer, Cesare Danesino, Franco Locatelli, Riccardo Masetti, Giuseppe Basso,  and Geertruy te Kronnie
28914-28919
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Integrative transcriptome analysis identifies deregulated microRNA-transcription factor networks in lung adenocarcinoma

Integrative transcriptome analysis identifies deregulated microRNA-transcription factor networks in lung adenocarcinoma

https://doi.org/10.18632/oncotarget.8713

Naiara C. Cinegaglia, Sonia Cristina S. Andrade, Tomas Tokar, Maísa Pinheiro, Fábio E. Severino, Rogério A. Oliveira, Erica N. Hasimoto, Daniele C. Cataneo, Antônio J.M. Cataneo, Júlio Defaveri, Cristiano P. Souza, Márcia M.C. Marques, Robson F. Carvalho, Luiz L. Coutinho, Jefferson L. Gross, Silvia R. Rogatto, Wan L. Lam, Igor Jurisica,  and Patricia P. Reis
28920-28934
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Cinobufagin inhibits tumor growth by inducing intrinsic apoptosis through AKT signaling pathway in human nonsmall cell lung cancer cells

Cinobufagin inhibits tumor growth by inducing intrinsic apoptosis through AKT signaling pathway in human nonsmall cell lung cancer cells

https://doi.org/10.18632/oncotarget.7898

Guangxin Zhang, Chao Wang, Mei Sun, Jindong Li, Bin Wang, Chengyan Jin, Peiyan Hua, Ge Song, Yifan Zhang, Lisa L.H. Nguyen, Ranji Cui, Runhua Liu, Lizhong Wang,  and Xingyi Zhang
28935-28946
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Western diet enhances benzo(a)pyrene-induced colon tumorigenesis in a polyposis in rat coli (PIRC) rat model of colon cancer

Western diet enhances benzo(a)pyrene-induced colon tumorigenesis in a polyposis in rat coli (PIRC) rat model of colon cancer

https://doi.org/10.18632/oncotarget.7901

Kelly L. Harris, Stephanie R. Pulliam, Emmanuel Okoro, Zhongmao Guo, Mary K. Washington, Samuel E. Adunyah, James M. Amos-Landgraf,  and Aramandla Ramesh
28947-28960
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Primary versus castration-resistant prostate cancer: modeling through novel murine prostate cancer cell lines

Primary versus castration-resistant prostate cancer: modeling through novel murine prostate cancer cell lines

https://doi.org/10.18632/oncotarget.8436

Georges Daoud, Alissar Monzer, Hisham Bahmad, Farah Chamaa, Layal Hamdar, Tarek H. Mouhieddine, Sami Shayya, Assaad Eid, Firas Kobeissy, Yen‑Nien Liu,  and Wassim Abou‑Kheir
28961-28975
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Functional genomics screen identifies YAP1 as a key determinant to enhance treatment sensitivity in lung cancer cells

Functional genomics screen identifies YAP1 as a key determinant to enhance treatment sensitivity in lung cancer cells

https://doi.org/10.18632/oncotarget.6721

Haiying Cheng, Zhenfeng Zhang, Ruth Rodriguez-Barrueco, Alain Borczuk, Huijie Liu, Jiyang Yu, Jose M. Silva, Simon K. Cheng, Roman Perez-Soler,  and Balazs Halmos
28976-28988
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shRNA targeting long non-coding RNA CCAT2 controlled by tetracycline-inducible system inhibits progression of bladder cancer cells

shRNA targeting long non-coding RNA CCAT2 controlled by tetracycline-inducible system inhibits progression of bladder cancer cells

https://doi.org/10.18632/oncotarget.8259

Jianfa Li, Chengle Zhuang, Yuchen Liu, Mingwei Chen, Qing Zhou, Zhicong Chen, Anbang He, Guoping Zhao, Yinglu Guo, Hanwei Wu, Zhiming Cai,  and Weiren Huang
28989-28997
Abstract  |  PDF  |  HTML  |  Order a Reprint

Autophagy-related cell death by pan-histone deacetylase inhibition in liver cancer

Autophagy-related cell death by pan-histone deacetylase inhibition in liver cancer

https://doi.org/10.18632/oncotarget.8585

Pietro Di Fazio, Petra Waldegger, Samir Jabari, Susanne Lingelbach, Roberta Montalbano, Matthias Ocker, Emily P. Slater, Detlef K. Bartsch, Romana Illig, Daniel Neureiter,  and Thaddeus T. Wissniowski
28998-29010
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Brigatinib, an anaplastic lymphoma kinase inhibitor, abrogates activity and growth in ALK-positive neuroblastoma cells, Drosophila and mice

Brigatinib, an anaplastic lymphoma kinase inhibitor, abrogates activity and growth in ALK-positive neuroblastoma cells, Drosophila and mice

https://doi.org/10.18632/oncotarget.8508

Joachim T. Siaw, Haiying Wan, Kathrin Pfeifer, Victor M. Rivera, Jikui Guan, Ruth H. Palmer,  and Bengt Hallberg
29011-29022
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

LOX is a novel mitotic spindle-associated protein essential for mitosis

LOX is a novel mitotic spindle-associated protein essential for mitosis

https://doi.org/10.18632/oncotarget.8628

Myriem Boufraqech, Darmood Wei, Urbain Weyemi, Lisa Zhang, Martha Quezado, Petr Kalab,  and Electron Kebebew
29023-29035
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Chemotherapy-induced uridine diphosphate release promotes breast cancer metastasis through P2Y6 activation

Chemotherapy-induced uridine diphosphate release promotes breast cancer metastasis through P2Y6 activation

https://doi.org/10.18632/oncotarget.8664

Xiaobin Ma, Xinhua Pan, Yinglei Wei, Binhe Tan, Linli Yang, Hua Ren, Min Qian,  and Bing Du
29036-29050
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

CD133+ cancer stem-like cells promote migration and invasion of salivary adenoid cystic carcinoma by inducing vasculogenic mimicry formation

CD133+ cancer stem-like cells promote migration and invasion of salivary adenoid cystic carcinoma by inducing vasculogenic mimicry formation

https://doi.org/10.18632/oncotarget.8665

Sha-sha Wang, Xiao-lei Gao, Xin Liu, Shi-yu Gao, Yun-long Fan, Ya-ping Jiang, Xiang-rui Ma, Jian Jiang, Hao Feng, Qian-ming Chen, Ya-jie Tang, Ya-ling Tang,  and Xin-hua Liang
29051-29062
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Targeting of short TRPM8 isoforms induces 4TM-TRPM8-dependent apoptosis in prostate cancer cells

Targeting of short TRPM8 isoforms induces 4TM-TRPM8-dependent apoptosis in prostate cancer cells

https://doi.org/10.18632/oncotarget.8666

Gabriel Bidaux, Anne-Sophie Borowiec, Charlotte Dubois, Philippe Delcourt, Céline Schulz, Fabien Vanden Abeele, Gilbert Lepage, Emilie Desruelles, Alexandre Bokhobza, Etienne Dewailly, Christian Slomianny, Morad Roudbaraki, Laurent Héliot, Jean-Louis Bonnal, Brigitte Mauroy, Pascal Mariot, Loïc Lemonnier,  and Natalia Prevarskaya
29063-29080
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

SOCS-1 rescues IL-1β-mediated suppression of epithelial sodium channel in mouse lung epithelial cells via ASK-1

SOCS-1 rescues IL-1β-mediated suppression of epithelial sodium channel in mouse lung epithelial cells via ASK-1

https://doi.org/10.18632/oncotarget.8543

Lakshmi Galam, Ramani Soundararajan, Mason Breitzig, Ashna Rajan, Rajashekar Reddy Yeruva, Alexander Czachor, Francine Harris, Richard F. Lockey,  and Narasaiah Kolliputi
29081-29091
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Efficacy of combined gemcitabine, oxaliplatin and pegaspargase (P-gemox regimen) in patients with newly diagnosed advanced-stage or relapsed/refractory extranodal NK/T-cell lymphoma

Efficacy of combined gemcitabine, oxaliplatin and pegaspargase (P-gemox regimen) in patients with newly diagnosed advanced-stage or relapsed/refractory extranodal NK/T-cell lymphoma

https://doi.org/10.18632/oncotarget.8647

Jing-hua Wang, Liang Wang, Cheng-cheng Liu, Zhong-jun Xia, Hui-qiang Huang, Tong-yu Lin, Wen-qi Jiang,  and Yue Lu
29092-29101
Abstract  |  PDF  |  HTML  |  Order a Reprint

Therapeutic potential and functional interaction of carfilzomib and vorinostat in T-cell leukemia/lymphoma

Therapeutic potential and functional interaction of carfilzomib and vorinostat in T-cell leukemia/lymphoma

https://doi.org/10.18632/oncotarget.8667

Minjie Gao, Gege Chen, Houcai Wang, Bingqian Xie, Liangning Hu, Yuanyuan Kong, Guang Yang, Yi Tao, Ying Han, Xiaosong Wu, Yiwen Zhang, Bojie Dai,  and Jumei Shi
29102-29115
Abstract  |  PDF  |  HTML  |  Order a Reprint

Magnolol and honokiol exert a synergistic anti-tumor effect through autophagy and apoptosis in human glioblastomas

Magnolol and honokiol exert a synergistic anti-tumor effect through autophagy and apoptosis in human glioblastomas

https://doi.org/10.18632/oncotarget.8674

Yu-Chen Cheng, Dueng-Yuan Hueng, Hua-Yin Huang, Jang-Yi Chen,  and Ying Chen
29116-29130
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Dual inhibition of AKT/FLT3-ITD by A674563 overcomes FLT3 ligand-induced drug resistance in FLT3-ITD positive AML

Dual inhibition of AKT/FLT3-ITD by A674563 overcomes FLT3 ligand-induced drug resistance in FLT3-ITD positive AML

https://doi.org/10.18632/oncotarget.8675

Aoli Wang, Hong Wu, Cheng Chen, Chen Hu, Ziping Qi, Wenchao Wang, Kailin Yu, Xiaochuan Liu, Fengming Zou, Zheng Zhao, Jiaxin Wu, Juan Liu, Feiyang Liu, Li Wang, Richard M. Stone, Ilene A. Galinksy, James D. Griffin, Shanchun Zhang, Ellen L. Weisberg, Jing Liu,  and Qingsong Liu
29131-29142
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Protective effects of alpha lipoic acid on radiation-induced salivary gland injury in rats

Protective effects of alpha lipoic acid on radiation-induced salivary gland injury in rats

https://doi.org/10.18632/oncotarget.8661

Jin Hyun Kim, Kyung Mi Kim, Myeong Hee Jung, Jung Hwa Jung, Ki Mun Kang, Bae Kwon Jeong, Jin Pyeong Kim, Jung Je Park,  and Seung Hoon Woo
29143-29153
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Circulating cell-free DNA has a high degree of specificity to detect exon 19 deletions and the single-point substitution mutation L858R in non-small cell lung cancer

Circulating cell-free DNA has a high degree of specificity to detect exon 19 deletions and the single-point substitution mutation L858R in non-small cell lung cancer

https://doi.org/10.18632/oncotarget.8684

Xin Qian, Jia Liu, Yuhui Sun, Meifang Wang, Huaiding Lei, Guoshi Luo, Xianjun Liu, Chang Xiong, Dan Liu, Jie Liu,  and Yijun Tang
29154-29165
Abstract  |  PDF  |  HTML  |  Order a Reprint

Mitochondrial DNA content in breast cancer: Impact on in vitro and in vivo phenotype and patient prognosis

Mitochondrial DNA content in breast cancer: Impact on in vitro and in vivo phenotype and patient prognosis

https://doi.org/10.18632/oncotarget.8688

Marjolein J.A. Weerts, Anieta M. Sieuwerts, Marcel Smid, Maxime P. Look, John A. Foekens, Stefan Sleijfer,  and John W.M. Martens
29166-29176
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Which patients with para-aortic lymph node (LN16) metastasis will truly benefit from curative pancreaticoduodenectomy for pancreatic head cancer?

Which patients with para-aortic lymph node (LN16) metastasis will truly benefit from curative pancreaticoduodenectomy for pancreatic head cancer?

https://doi.org/10.18632/oncotarget.8690

Chen Liu, Yu Lu, Guopei Luo, He Cheng, Meng Guo, Zuqiang Liu, Jin Xu, Jiang Long, Liang Liu, Deliang Fu, Quanxing Ni, Min Li,  and Xianjun Yu
29177-29186
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Acquired resistance to combination treatment through loss of synergy with MEK and PI3K inhibitors in colorectal cancer

Acquired resistance to combination treatment through loss of synergy with MEK and PI3K inhibitors in colorectal cancer

https://doi.org/10.18632/oncotarget.8692

Bhaskar Bhattacharya, Sarah Hong Hui Low, Mei Ling Chong, Dilys Chia, King Xin Koh, Nur Sabrina Sapari, Stanley Kaye, Huynh Hung, Touati Benoukraf,  and Richie Soong
29187-29198
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

CRKL mediates EML4-ALK signaling and is a potential therapeutic target for ALK-rearranged lung adenocarcinoma

CRKL mediates EML4-ALK signaling and is a potential therapeutic target for ALK-rearranged lung adenocarcinoma

https://doi.org/10.18632/oncotarget.8638

Rong An, Yisong Wang, Donna Voeller, Arjan Gower, In-Kyu Kim, Yu-Wen Zhang,  and Giuseppe Giaccone
29199-29210
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Whole exome sequencing of urachal adenocarcinoma reveals recurrent NF1 mutations

Whole exome sequencing of urachal adenocarcinoma reveals recurrent NF1 mutations

https://doi.org/10.18632/oncotarget.8640

Harshabad Singh, Yang Liu, Xiuli Xiao, Ling Lin, Jaegil Kim, Paul Van Hummelen, Chin-Lee Wu, Adam J. Bass,  and Philip J. Saylor
29211-29215
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Silencing homeobox C6 inhibits colorectal cancer cell proliferation

Silencing homeobox C6 inhibits colorectal cancer cell proliferation

https://doi.org/10.18632/oncotarget.8703

Meiling Ji, Qingyang Feng, Guodong He, Liangliang Yang, Wentao Tang, Xinyuan Lao, Dexiang Zhu, Qi Lin, Pingping Xu, Ye Wei,  and Jianmin Xu
29216-29227
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s-SHIP expression identifies a subset of murine basal prostate cells as neonatal stem cells

s-SHIP expression identifies a subset of murine basal prostate cells as neonatal stem cells

https://doi.org/10.18632/oncotarget.8709

Guillaume Brocqueville, Renee S. Chmelar, Hélène Bauderlique-Le Roy, Emeric Deruy, Lu Tian, Robert L. Vessella, Norman M. Greenberg, Larry R. Rohrschneider,  and Roland P. Bourette
29228-29244
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Regulation of tumor suppressor EAF2 polyubiquitination by ELL1 and SIAH2 in prostate cancer cells

Regulation of tumor suppressor EAF2 polyubiquitination by ELL1 and SIAH2 in prostate cancer cells

https://doi.org/10.18632/oncotarget.8588

Xinpei Yu, Junkui Ai, Liquan Cai, Yifeng Jing, Dan Wang, Jun Dong, Laura E. Pascal, Jian Zhang, Rongcheng Luo,  and Zhou Wang
29245-29254
Abstract  |  PDF  |  HTML  |  Order a Reprint

SIRT1 facilitates hepatocellular carcinoma metastasis by promoting PGC-1α-mediated mitochondrial biogenesis

SIRT1 facilitates hepatocellular carcinoma metastasis by promoting PGC-1α-mediated mitochondrial biogenesis

https://doi.org/10.18632/oncotarget.8711

Yuming Li, Shangcheng Xu, Jing Li, Lu Zheng, Min Feng, Xiaoya Wang, Keqiang Han, Huifeng Pi, Min Li, Xiaobing Huang, Nan You, Yewang Tian, Guohua Zuo, Hongyan Li, Hongzhi Zhao, Ping Deng, Zhengping Yu, Zhou Zhou,  and Ping Liang
29255-29274
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MiR-320a inhibits gastric carcinoma by targeting activity in the FoxM1-P27KIP1 axis

MiR-320a inhibits gastric carcinoma by targeting activity in the FoxM1-P27KIP1 axis

https://doi.org/10.18632/oncotarget.8676

Yangyang Wang, Jiping Zeng, Jianyong Pan, Xue Geng, Lupeng Li, Jing Wu, Ping Song, Ying Wang, Jilan Liu,  and Lixiang Wang
29275-29286
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Comparative proteomics of exosomes secreted by tumoral Jurkat T cells and normal human T cell blasts unravels a potential tumorigenic role for valosin-containing protein

Comparative proteomics of exosomes secreted by tumoral Jurkat T cells and normal human T cell blasts unravels a potential tumorigenic role for valosin-containing protein

https://doi.org/10.18632/oncotarget.8678

Alberto Bosque, Lisa Dietz, Ana Gallego-Lleyda, Manuel Sanclemente, María Iturralde, Javier Naval, María Angeles Alava, Luis Martínez-Lostao, Hermann-Josef Thierse,  and Alberto Anel
29287-29305
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Nuclear factor one B (NFIB) encodes a subtype-specific tumour suppressor in glioblastoma

Nuclear factor one B (NFIB) encodes a subtype-specific tumour suppressor in glioblastoma

https://doi.org/10.18632/oncotarget.8720

Brett W. Stringer, Jens Bunt, Bryan W. Day, Guy Barry, Paul R. Jamieson, Kathleen S. Ensbey, Zara C. Bruce, Kate Goasdoué, Hélène Vidal, Sara Charmsaz, Fiona M. Smith, Leanne T. Cooper, Michael Piper, Andrew W. Boyd,  and Linda J. Richards
29306-29320
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Can the microRNA expression profile help to identify novel targets for zoledronic acid in breast cancer?

Can the microRNA expression profile help to identify novel targets for zoledronic acid in breast cancer?

https://doi.org/10.18632/oncotarget.8722

Daniele Fanale, Valeria Amodeo, Viviana Bazan, Lavinia Insalaco, Lorena Incorvaia, Nadia Barraco, Marta Castiglia, Sergio Rizzo, Daniele Santini, Antonio Giordano, Sergio Castorina,  and Antonio Russo
29321-29332
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Reduced expression of CD109 in tumor-associated endothelial cells promotes tumor progression by paracrine interleukin-8 in hepatocellular carcinoma

Reduced expression of CD109 in tumor-associated endothelial cells promotes tumor progression by paracrine interleukin-8 in hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.8787

Bo-Gen Ye, Hui-Chuan Sun, Xiao-Dong Zhu, Zong-Tao Chai, Yuan-Yuan Zhang, Jian-Yang Ao, Hao Cai, De-Ning Ma, Cheng-Hao Wang, Cheng-Dong Qin, Dong-Mei Gao,  and Zhao-You Tang
29333-29345
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

GP73-regulated oncolytic adenoviruses possess potent killing effect on human liver cancer stem-like cells

GP73-regulated oncolytic adenoviruses possess potent killing effect on human liver cancer stem-like cells

https://doi.org/10.18632/oncotarget.8830

Xinmin Zhang, Shulin Meng, Rong Zhang, Buyun Ma, Tao Liu, Yu Yang, Wenjie Xie, Xianglei Liu, Fang Huang, Tao Liu, Xiumei Zhou, Xinyuan Liu,  and Yigang Wang
29346-29358
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Wip1 suppresses ovarian cancer metastasis through the ATM/AKT/Snail mediated signaling

Wip1 suppresses ovarian cancer metastasis through the ATM/AKT/Snail mediated signaling

https://doi.org/10.18632/oncotarget.8833

Sheng Yin, Pan Wang, Lina Yang, Yang Liu, Yan Wang, Mingming Liu, Zihao Qi, Jiao Meng, Ting-Yan Shi, Gong Yang,  and Rongyu Zang
29359-29370
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Sox9 confers stemness properties in hepatocellular carcinoma through Frizzled-7 mediated Wnt/β-catenin signaling

Sox9 confers stemness properties in hepatocellular carcinoma through Frizzled-7 mediated Wnt/β-catenin signaling

https://doi.org/10.18632/oncotarget.8835

Carmen Oi-Ning Leung, Wing-Nga Mak, Alan Ka-Lun Kai, Kwan-Shuen Chan, Terence Kin-Wah Lee, Irene Oi-Lin Ng,  and Regina Cheuk-Lam Lo
29371-29386
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JMJD3 promotes survival of diffuse large B-cell lymphoma subtypes via distinct mechanisms

JMJD3 promotes survival of diffuse large B-cell lymphoma subtypes via distinct mechanisms

https://doi.org/10.18632/oncotarget.8836

Yan Zhang, Long Shen, Dwayne G. Stupack, Nan Bai, Jing Xun, Guosheng Ren, Jihong Han, Luyuan Li, Yunping Luo, Rong Xiang,  and Xiaoyue Tan
29387-29399
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Anti-miR delivery strategies to bypass the blood-brain barrier in glioblastoma therapy

Anti-miR delivery strategies to bypass the blood-brain barrier in glioblastoma therapy

https://doi.org/10.18632/oncotarget.8837

Dong Geon Kim, Kang Ho Kim, Yun Jee Seo, Heekyoung Yang, Eric G. Marcusson, Eunju Son, Kyoungmin Lee, Jason K. Sa, Hye Won Lee,  and Do-Hyun Nam
29400-29411
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The role of histological subtype in hormone receptor positive metastatic breast cancer: similar survival but different therapeutic approaches

The role of histological subtype in hormone receptor positive metastatic breast cancer: similar survival but different therapeutic approaches

https://doi.org/10.18632/oncotarget.8838

Dorien Lobbezoo, Wilfred Truin, Adri Voogd, Rudi Roumen, Gerard Vreugdenhil, Marcus Wouter Dercksen, Franchette van den Berkmortel, Tineke Smilde, Agnes van de Wouw, Roel van Kampen, Johanna van Riel, Natascha Peters, Petronella Peer,  and Vivianne C.G. Tjan-Heijnen
29412-29419
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Lymph node ratio may predict the benefit of postoperative radiotherapy in node-positive cervical cancer

Lymph node ratio may predict the benefit of postoperative radiotherapy in node-positive cervical cancer

https://doi.org/10.18632/oncotarget.8840

Juan Zhou, Qiong-Hua Chen, San-Gang Wu, Zhen-Yu He, Jia-Yuan Sun, Feng-Yan Li, Huan-Xin Lin,  and Ke-Li You
29420-29428
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Pinin facilitated proliferation and metastasis of colorectal cancer through activating EGFR/ERK signaling pathway

Pinin facilitated proliferation and metastasis of colorectal cancer through activating EGFR/ERK signaling pathway

https://doi.org/10.18632/oncotarget.8738

Zhigang Wei, Wenhui Ma, Xiaolong Qi, Xianjun Zhu, Yutian Wang, Zhuoluo Xu, Jun Luo, Da Wang, Weihong Guo, Xiaomei Li, Sainan Xin, Jiang Yu,  and Guoxin Li
29429-29439
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The cellular distribution of Na+/H+ exchanger regulatory factor 1 is determined by the PDZ-I domain and regulates the malignant progression of breast cancer

The cellular distribution of Na+/H+ exchanger regulatory factor 1 is determined by the PDZ-I domain and regulates the malignant progression of breast cancer

https://doi.org/10.18632/oncotarget.8751

Guifang Du, Yanan Gu, Chengcheng Hao, Zhu Yuan, Junqi He, Wen G. Jiang,  and Shan Cheng
29440-29453
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

NMR-based fecal metabolomics fingerprinting as predictors of earlier diagnosis in patients with colorectal cancer

NMR-based fecal metabolomics fingerprinting as predictors of earlier diagnosis in patients with colorectal cancer

https://doi.org/10.18632/oncotarget.8762

Yan Lin, Changchun Ma, Chengkang Liu, Zhening Wang, Jurong Yang, Xinmu Liu, Zhiwei Shen,  and Renhua Wu
29454-29464
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Human growth hormone and human prolactin function as autocrine/paracrine promoters of progression of hepatocellular carcinoma

Human growth hormone and human prolactin function as autocrine/paracrine promoters of progression of hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.8781

Xiangjun Kong, Wenyong Wu, Yan Yuan, Vijay Pandey, Zhengsheng Wu, Xuefei Lu, Weijie Zhang, Yijun Chen, Mingming Wu, Min Zhang, Gaopeng Li, Sheng Tan, Pengxu Qian, Jo K. Perry, Peter E. Lobie,  and Tao Zhu
29465-29479
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

B7-H3 as a promising target for cytotoxicity T cell in human cancer therapy

B7-H3 as a promising target for cytotoxicity T cell in human cancer therapy

https://doi.org/10.18632/oncotarget.8784

Juan Ma, Pan Ma, Chenghai Zhao, Xin Xue, Huamin Han, Changzhen Liu, Hua Tao, Weigang Xiu, Jia Cai,  and Man Zhang
29480-29491
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Inhibition of pro-HGF activation by SRI31215, a novel approach to block oncogenic HGF/MET signaling

Inhibition of pro-HGF activation by SRI31215, a novel approach to block oncogenic HGF/MET signaling

https://doi.org/10.18632/oncotarget.8785

Benjamin Y. Owusu, Namita Bansal, Phanindra K.M. Venukadasula, Larry J. Ross, Troy E. Messick, Sanjay Goel, Robert A. Galemmo,  and Lidija Klampfer
29492-29506
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Knockdown of CMTM3 promotes metastasis of gastric cancer via the STAT3/Twist1/EMT signaling pathway

Knockdown of CMTM3 promotes metastasis of gastric cancer via the STAT3/Twist1/EMT signaling pathway

https://doi.org/10.18632/oncotarget.8789

Wanqiong Yuan, Ting Li, Xiaoning Mo, Xiaolin Wang, Baocai Liu, Wenyan Wang, Yu Su, Lan Xu,  and Wenling Han
29507-29519
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Targeting of Chk2 as a countermeasure to dose-limiting toxicity triggered by topoisomerase-II (TOP2) poisons

Targeting of Chk2 as a countermeasure to dose-limiting toxicity triggered by topoisomerase-II (TOP2) poisons

https://doi.org/10.18632/oncotarget.8790

Prashanth Gokare, Arunasalam Navaraj, Shengliang Zhang, Noboru Motoyama, Shen-Shu Sung,  and Niklas K. Finnberg
29520-29530
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Deciphering the role of nuclear and cytoplasmic IKKα in skin cancer

Deciphering the role of nuclear and cytoplasmic IKKα in skin cancer

https://doi.org/10.18632/oncotarget.8792

Josefa P. Alameda, Miriam Gaspar, Ángel Ramírez, Manuel Navarro, Angustias Page, Cristian Suárez-Cabrera, Guadalupe M. Fernández, Jose R. Mérida, Jesús M. Paramio, Rosa A. García-Fernández, Jesús M. Fernández- Aceñero,  and Llanos M. Casanova
29531-29547
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Hypoxia promotes Rab5 activation, leading to tumor cell migration, invasion and metastasis

Hypoxia promotes Rab5 activation, leading to tumor cell migration, invasion and metastasis

https://doi.org/10.18632/oncotarget.8794

Patricio Silva, Pablo Mendoza, Solange Rivas, Jorge Díaz, Carolina Moraga, Andrew F.G. Quest,  and Vicente A. Torres
29548-29562
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Benzyl butyl phthalate promotes breast cancer stem cell expansion via SPHK1/S1P/S1PR3 signaling

Benzyl butyl phthalate promotes breast cancer stem cell expansion via SPHK1/S1P/S1PR3 signaling

https://doi.org/10.18632/oncotarget.9007

Yu-Chih Wang, Cheng-Fang Tsai, Hsiao-Li Chuang, Yi-Chih Chang, Hung-Sheng Chen, Jau-Nan Lee,  and Eing-Mei Tsai
29563-29576
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Synergistic antitumor effects of combination PI3K/mTOR and MEK inhibition (SAR245409 and pimasertib) in mucinous ovarian carcinoma cells by fluorescence resonance energy transfer imaging

Synergistic antitumor effects of combination PI3K/mTOR and MEK inhibition (SAR245409 and pimasertib) in mucinous ovarian carcinoma cells by fluorescence resonance energy transfer imaging

https://doi.org/10.18632/oncotarget.8807

Kanako Inaba, Katsutoshi Oda, Kazuhiro Aoki, Kenbun Sone, Yuji Ikeda, Aki Miyasaka, Tomoko Kashiyama, Tomohiko Fukuda, Chinami Makii, Takahide Arimoto, Osamu Wada-Hiraike, Kei Kawana, Tetsu Yano, Yutaka Osuga,  and Tomoyuki Fujii
29577-29591
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Ninjurin1 inhibits colitis-mediated colon cancer development and growth by suppression of macrophage infiltration through repression of FAK signaling

Ninjurin1 inhibits colitis-mediated colon cancer development and growth by suppression of macrophage infiltration through repression of FAK signaling

https://doi.org/10.18632/oncotarget.9020

Jong Kyu Woo, Yeong-Su Jang, Ju-Hee Kang, Jong-Ik Hwang, Je Kyung Seong, Sang-Jin Lee, Sejin Jeon, Goo Taeg Oh, Ho-Young Lee,  and Seung Hyun Oh
29592-29604
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Downregulation of amplified in breast cancer 1 contributes to the anti-tumor effects of sorafenib on human hepatocellular carcinoma

Downregulation of amplified in breast cancer 1 contributes to the anti-tumor effects of sorafenib on human hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.8812

Ming Li, Wei Wang, Yuzhen Dan, Zhangwei Tong, Wenbo Chen, Liping Qin, Kun Liu, Wengang Li, Pingli Mo,  and Chundong Yu
29605-29619
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

TREM-2 serves as a negative immune regulator through Syk pathway in an IL-10 dependent manner in lung cancer

TREM-2 serves as a negative immune regulator through Syk pathway in an IL-10 dependent manner in lung cancer

https://doi.org/10.18632/oncotarget.8813

Yinan Yao, Hequan Li, Junjun Chen, Weiyi Xu, Guangdie Yang, Zhang Bao, Dajing Xia, Guohua Lu, Shuwen Hu,  and Jianying Zhou
29620-29634
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Colorectal cancer cells display chaperone dependency for the unconventional prefoldin URI1

Colorectal cancer cells display chaperone dependency for the unconventional prefoldin URI1

https://doi.org/10.18632/oncotarget.8816

Kamil Andrzej Lipinski, Christian Britschgi, Karen Schrader, Yann Christinat, Lukas Frischknecht,  and Wilhelm Krek
29635-29647
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

X66, a novel N-terminal heat shock protein 90 inhibitor, exerts antitumor effects without induction of heat shock response

X66, a novel N-terminal heat shock protein 90 inhibitor, exerts antitumor effects without induction of heat shock response

https://doi.org/10.18632/oncotarget.8818

Zhixin Zhao, Jianming Zhu, Haitian Quan, Guimin Wang, Bo Li, Weiliang Zhu, Chengying Xie,  and Liguang Lou
29648-29663
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The La protein counteracts cisplatin-induced cell death by stimulating protein synthesis of anti-apoptotic factor Bcl2

The La protein counteracts cisplatin-induced cell death by stimulating protein synthesis of anti-apoptotic factor Bcl2

https://doi.org/10.18632/oncotarget.8819

Tilman Heise, Venkatesh Kota, Alexander Brock, Amanda B. Morris, Reycel M. Rodriguez, Avery W. Zierk, Philip H. Howe,  and Gunhild Sommer
29664-29676
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Gene expression profiling of normal thyroid tissue from patients with thyroid carcinoma

Gene expression profiling of normal thyroid tissue from patients with thyroid carcinoma

https://doi.org/10.18632/oncotarget.8820

Roberto Ria, Vittorio Simeon, Assunta Melaccio, Giovanna Di Meo, Stefania Trino, Carmela Mazzoccoli, Ilaria Saltarella, Aurelia Lamanuzzi, Annalisa Morano, Angela Gurrado, Alessandro Pasculli, Gaetano Lastilla, Pellegrino Musto, Antonia Reale, Franco Dammacco, Angelo Vacca,  and Mario Testini
29677-29688
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The transcription factor RUNX2 regulates receptor tyrosine kinase expression in melanoma

The transcription factor RUNX2 regulates receptor tyrosine kinase expression in melanoma

https://doi.org/10.18632/oncotarget.8822

Rajeev K. Boregowda, Daniel J. Medina, Elke Markert, Michael A. Bryan, Wenjin Chen, Suzie Chen, Anna Rabkin, Michael J. Vido, Samuel I. Gunderson, Marina Chekmareva, David J. Foran, Ahmed Lasfar, James S. Goydos,  and Karine A. Cohen-Solal
29689-29707
Abstract  |  PDF  |  HTML  |  Order a Reprint

Nomograms for predicting long-term survival in patients with non-metastatic nasopharyngeal carcinoma in an endemic area

Nomograms for predicting long-term survival in patients with non-metastatic nasopharyngeal carcinoma in an endemic area

https://doi.org/10.18632/oncotarget.8823

Qi Zeng, Ming-Huang Hong, Lu-Jun Shen, Xiang-Qi Meng, Xiang Guo, Chao-Nan Qian, Pei-Hong Wu,  and Pei-Yu Huang
29708-29719
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Relapse-related long non-coding RNA signature to improve prognosis prediction of lung adenocarcinoma

Relapse-related long non-coding RNA signature to improve prognosis prediction of lung adenocarcinoma

https://doi.org/10.18632/oncotarget.8825

Meng Zhou, Wanying Xu, Xiaolong Yue, Hengqiang Zhao, Zhenzhen Wang, Hongbo Shi, Liang Cheng,  and Jie Sun
29720-29738
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Induction chemotherapy followed by concurrent chemoradiotherapy versus concurrent chemoradiotherapy alone in stage III-IVb nasopharyngeal carcinoma patients with Epstein-Barr virus DNA ≥4000 copies/ml: a matched study

Induction chemotherapy followed by concurrent chemoradiotherapy versus concurrent chemoradiotherapy alone in stage III-IVb nasopharyngeal carcinoma patients with Epstein-Barr virus DNA ≥4000 copies/ml: a matched study

https://doi.org/10.18632/oncotarget.8828

Shan-Shan Guo, Lin-Quan Tang, Qiu-Yan Chen, Lu Zhang, Li-Ting Liu, Ling Guo, Hao-Yuan Mo, Dong-Hua Luo, Pei-Yu Huang, Yan-Qun Xiang, Rui Sun, Ming-Yuan Chen, Lin Wang, Xing Lv, Chong Zhao, Xiang Guo, Ka-Jia Cao, Chao-Nan Qian, Mu-Shen Zeng, Jin-Xin Bei, Ming-Huang Hong, Jian-Yong Shao, Ying Sun, Jun Ma,  and Hai-Qiang Mai
29739-29748
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Suppression of epithelial-mesenchymal transition in hepatocellular carcinoma cells by Krüppel-like factor 4

Suppression of epithelial-mesenchymal transition in hepatocellular carcinoma cells by Krüppel-like factor 4

https://doi.org/10.18632/oncotarget.8831

Qi Li, Weifeng Song, Weiyu Wang, Shanshan Yao, Chuan Tian, Xun Cai,  and Liwei Wang
29749-29760
Abstract  |  PDF  |  HTML  |  Order a Reprint

Genetic changes of non-small cell lung cancer under neoadjuvant therapy

Genetic changes of non-small cell lung cancer under neoadjuvant therapy

https://doi.org/10.18632/oncotarget.8858

Arne Warth, Volker Endris, Albrecht Stenzinger, Roland Penzel, Alexander Harms, Thomas Duell, Amir Abdollahi, Michael Lindner, Peter Schirmacher, Thomas Muley, Hendrik Dienemann, Ludger Fink, Alicia Morresi-Hauf, Nicole Pfarr,  and Wilko Weichert
29761-29769
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Two variants on T2DM susceptible gene HHEX are associated with CRC risk in a Chinese population

Two variants on T2DM susceptible gene HHEX are associated with CRC risk in a Chinese population

https://doi.org/10.18632/oncotarget.8865

Rui Sun, Jian-Ping Liu, Chang Gao, Ying-Ying Xiong, Min Li, Ya-Ping Wang, Yan-Wei Su, Mei Lin, An-Li Jiang, Ling-Fan Xiong, Yan Xie,  and Jue-Ping Feng
29770-29779
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Impact of PI3K/AKT/mTOR pathway activation on the prognosis of patients with head and neck squamous cell carcinomas

Impact of PI3K/AKT/mTOR pathway activation on the prognosis of patients with head and neck squamous cell carcinomas

https://doi.org/10.18632/oncotarget.8957

Darío García-Carracedo, Maria Ángeles Villaronga, Saúl Álvarez-Teijeiro, Francisco Hermida-Prado, Iñigo Santamaría, Eva Allonca, Laura Suárez-Fernández, Maria Victoria Gonzalez, Milagros Balbín, Aurora Astudillo, Pablo Martínez-Camblor, Gloria H. Su, Juan Pablo Rodrigo,  and Juana María García-Pedrero
29780-29793
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Reviews

The effect of chemotherapy on programmed cell death 1/programmed cell death 1 ligand axis: some chemotherapeutical drugs may finally work through immune response

The effect of chemotherapy on programmed cell death 1/programmed cell death 1 ligand axis: some chemotherapeutical drugs may finally work through immune response

https://doi.org/10.18632/oncotarget.7631

Min Luo,  and Liwu Fu
29794-29803
Abstract  |  PDF  |  HTML  |  Order a Reprint

Notch signaling: its roles and therapeutic potential in hematological malignancies

Notch signaling: its roles and therapeutic potential in hematological malignancies

https://doi.org/10.18632/oncotarget.7772

Yisu Gu, Massimo Masiero,  and Alison H. Banham
29804-29823
Abstract  |  PDF  |  HTML  |  Order a Reprint

shRNA-armed conditionally replicative adenoviruses: a promising approach for cancer therapy

shRNA-armed conditionally replicative adenoviruses: a promising approach for cancer therapy

https://doi.org/10.18632/oncotarget.8035

Jie Zhang, Meng Ding, Kai Xu, Lijun Mao,  and Junian Zheng
29824-29834
Abstract  |  PDF  |  HTML  |  Order a Reprint

Emerging preclinical pharmacological targets for Parkinson’s disease

Emerging preclinical pharmacological targets for Parkinson’s disease

https://doi.org/10.18632/oncotarget.8104

Sandeep Vasant More,  and Dong-Kug Choi
29835-29863
Abstract  |  PDF  |  HTML  |  Order a Reprint

CHIP: A new modulator of human malignant disorders

CHIP: A new modulator of human malignant disorders

https://doi.org/10.18632/oncotarget.8219

Zhe Cao, Guanqiao Li, Qianqian Shao, Gang Yang, Lianfang Zheng, Taiping Zhang,  and Yupei Zhao
29864-29874
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