Oncotarget

Vol 7, No 17

April 26, 2016

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Addiction to Runx1 is partially attenuated by loss of p53 in the Eμ-Myc lymphoma model. See Borland et al.

Table of Contents

Editorial

Lessons learned from a SIRT2-selective inhibitor

Lessons learned from a SIRT2-selective inhibitor

https://doi.org/10.18632/oncotarget.8502

Hui Jing,  and Hening Lin
22971-22972
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Priority Research Papers

Addiction to Runx1 is partially attenuated by loss of p53 in the Eµ-Myc lymphoma model

Addiction to Runx1 is partially attenuated by loss of p53 in the Eµ-Myc lymphoma model

https://doi.org/10.18632/oncotarget.8554

Gillian Borland, Anna Kilbey, Jodie Hay, Kathryn Gilroy, Anne Terry, Nancy Mackay, Margaret Bell, Alma McDonald, Ken Mills, Ewan Cameron,  and James C. Neil
22973-22987
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Research Papers: Gerotarget (Focus on Aging)

Neuroendocrine immunomodulation network dysfunction in SAMP8 mice and PrP-hAβPPswe/PS1ΔE9 mice: potential mechanism underlying cognitive impairment

Neuroendocrine immunomodulation network dysfunction in SAMP8 mice and PrP-hAβPPswe/PS1ΔE9 mice: potential mechanism underlying cognitive impairment

https://doi.org/10.18632/oncotarget.8453

Jian-hui Wang, Xiao-rui Cheng, Xiao-rui Zhang, Tong-xing Wang, Wen-jian Xu, Fei Li, Feng Liu, Jun-ping Cheng, Xiao-chen Bo, Sheng-qi Wang, Wen-xia Zhou,  and Yong-xiang Zhang
22988-23005
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Epidermal Nbn deletion causes premature hair loss and a phenotype resembling psoriasiform dermatitis

Epidermal Nbn deletion causes premature hair loss and a phenotype resembling psoriasiform dermatitis

https://doi.org/10.18632/oncotarget.8470

Philipp Seidel, Martina Remus, Michael Delacher, Paulius Grigaravicius, David E. Reuss, Lucien Frappart, Andreas von Deimling, Markus Feuerer, Amir Abdollahi,  and Pierre-Olivier Frappart
23006-23018
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Adipose triglyceride lipase decrement affects skeletal muscle homeostasis during aging through FAs-PPARα-PGC-1α antioxidant response

Adipose triglyceride lipase decrement affects skeletal muscle homeostasis during aging through FAs-PPARα-PGC-1α antioxidant response

https://doi.org/10.18632/oncotarget.8552

Katia Aquilano, Sara Baldelli, Livia La Barbera, Daniele Lettieri Barbato, Giuseppe Tatulli,  and Maria Rosa Ciriolo
23019-23032
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Nitrogen and carbon source balance determines longevity, independently of fermentative or respiratory metabolism in the yeast Saccharomyces cerevisiae

Nitrogen and carbon source balance determines longevity, independently of fermentative or respiratory metabolism in the yeast Saccharomyces cerevisiae

https://doi.org/10.18632/oncotarget.8656

Júlia Santos, Fernanda Leitão-Correia, Maria João Sousa,  and Cecília Leão
23033-23042
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Research Papers: Pathology

Comprehensive analysis of the transcriptional profile of the Mediator complex across human cancer types

Comprehensive analysis of the transcriptional profile of the Mediator complex across human cancer types

https://doi.org/10.18632/oncotarget.8469

Isabella Syring, Niklas Klümper, Anne Offermann, Martin Braun, Mario Deng, Diana Boehm, Angela Queisser, Anne von Mässenhausen, Johannes Brägelmann, Wenzel Vogel, Doris Schmidt, Michael Majores, Anne Schindler, Glen Kristiansen, Stefan C. Müller, Jörg Ellinger, Zaki Shaikhibrahim,  and Sven Perner
23043-23055
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Circadian factors BMAL1 and RORα control HIF-1α transcriptional activity in nucleus pulposus cells: implications in maintenance of intervertebral disc health

Circadian factors BMAL1 and RORα control HIF-1α transcriptional activity in nucleus pulposus cells: implications in maintenance of intervertebral disc health

https://doi.org/10.18632/oncotarget.8521

Kaori Suyama, Elizabeth S. Silagi, Hyowon Choi, Kou Sakabe, Joji Mochida, Irving M. Shapiro,  and Makarand V. Risbud
23056-23071
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The pathological role of advanced glycation end products-downregulated heat shock protein 60 in islet β-cell hypertrophy and dysfunction

The pathological role of advanced glycation end products-downregulated heat shock protein 60 in islet β-cell hypertrophy and dysfunction

https://doi.org/10.18632/oncotarget.8604

Siao-Syun Guan, Meei-Ling Sheu, Rong-Sen Yang, Ding-Cheng Chan, Cheng-Tien Wu, Ting-Hua Yang, Chih-Kang Chiang,  and Shing-Hwa Liu
23072-23087
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Effect of CTLA-4 gene polymorphisms on long-term kidney allograft function in Han Chinese recipients

Effect of CTLA-4 gene polymorphisms on long-term kidney allograft function in Han Chinese recipients

https://doi.org/10.18632/oncotarget.8714

Yifeng Guo, Junwei Gao, Shuai Gao, Minghua Shang,  and Fang Guo
23088-23095
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Research Papers: Immunology

Role of p85α in neutrophil extra- and intracellular reactive oxygen species generation

Role of p85α in neutrophil extra- and intracellular reactive oxygen species generation

https://doi.org/10.18632/oncotarget.8500

Xing Jun Li, Lisa Deng, Stephanie L. Brandt, Charles B. Goodwin, Peilin Ma, Zhenyun Yang, Raghu S. Mali, Ziyue Liu, Reuben Kapur, C. Henrique Serezani,  and Rebecca J. Chan
23096-23105
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Reviews

The emerging role of FTY720 (Fingolimod) in cancer treatment

The emerging role of FTY720 (Fingolimod) in cancer treatment

https://doi.org/10.18632/oncotarget.7145

Christopher White, Heba Alshaker, Colin Cooper, Matthias Winkler,  and Dmitri Pchejetski
23106-23127
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Does an NKT-cell-based immunotherapeutic approach have a future in multiple myeloma?

Does an NKT-cell-based immunotherapeutic approach have a future in multiple myeloma?

https://doi.org/10.18632/oncotarget.7440

Mérédis Favreau, Karin Vanderkerken, Dirk Elewaut, Koen Venken,  and Eline Menu
23128-23140
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The altered glucose metabolism in tumor and a tumor acidic microenvironment associated with extracellular matrix metalloproteinase inducer and monocarboxylate transporters

The altered glucose metabolism in tumor and a tumor acidic microenvironment associated with extracellular matrix metalloproteinase inducer and monocarboxylate transporters

https://doi.org/10.18632/oncotarget.8153

Xiaofeng Li, Xiaozhou Yu, Dong Dai, Xiuyu Song,  and Wengui Xu
23141-23155
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Research Papers

Double-strand break repair and colorectal cancer: gene variants within 3′ UTRs and microRNAs binding as modulators of cancer risk and clinical outcome

Double-strand break repair and colorectal cancer: gene variants within 3′ UTRs and microRNAs binding as modulators of cancer risk and clinical outcome

https://doi.org/10.18632/oncotarget.6804

Alessio Naccarati, Fabio Rosa, Veronika Vymetalkova, Elisa Barone, Katerina Jiraskova, Cornelia Di Gaetano, Jan Novotny, Miroslav Levy, Ludmila Vodickova, Federica Gemignani, Tomas Buchler, Stefano Landi, Pavel Vodicka,  and Barbara Pardini
23156-23169
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hsa-miR-9 controls the mobility behavior of glioblastoma cells via regulation of MAPK14 signaling elements

hsa-miR-9 controls the mobility behavior of glioblastoma cells via regulation of MAPK14 signaling elements

https://doi.org/10.18632/oncotarget.6687

Rotem Ben-Hamo, Alona Zilberberg, Helit Cohen,  and Sol Efroni
23170-23181
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MRP1-CD28 bi-specific oligonucleotide aptamers: target costimulation to drug-resistant melanoma cancer stem cells

MRP1-CD28 bi-specific oligonucleotide aptamers: target costimulation to drug-resistant melanoma cancer stem cells

https://doi.org/10.18632/oncotarget.8095

Mario Martínez Soldevilla, Helena Villanueva, Noelia Casares, Juan Jose Lasarte, Maurizio Bendandi, Susana Inoges, Ascensión López-Díaz de Cerio,  and Fernando Pastor
23182-23196
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STARD13-correlated ceRNA network inhibits EMT and metastasis of breast cancer

STARD13-correlated ceRNA network inhibits EMT and metastasis of breast cancer

https://doi.org/10.18632/oncotarget.8099

Xiaoman Li, Lufeng Zheng, Feng Zhang, Jinhang Hu, Jinjiang Chou, Yu Liu, Yingying Xing,  and Tao Xi
23197-23211
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E2F1-induced upregulation of long noncoding RNA LINC00668 predicts a poor prognosis of gastric cancer and promotes cell proliferation through epigenetically silencing of CKIs

E2F1-induced upregulation of long noncoding RNA LINC00668 predicts a poor prognosis of gastric cancer and promotes cell proliferation through epigenetically silencing of CKIs

https://doi.org/10.18632/oncotarget.6745

Erbao Zhang, Dandan Yin, Liang Han, Xuezhi He, Xinxin Si, Wenming Chen, Rui Xia, Tongpeng Xu, Dongying Gu, Wei De, Renhua Guo, Zhi Xu,  and Jinfei Chen
23212-23226
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Advanced malignancies treated with a combination of the VEGF inhibitor bevacizumab, anti-EGFR antibody cetuximab, and the mTOR inhibitor temsirolimus

Advanced malignancies treated with a combination of the VEGF inhibitor bevacizumab, anti-EGFR antibody cetuximab, and the mTOR inhibitor temsirolimus

https://doi.org/10.18632/oncotarget.7594

Xiaochun Liu, Susan Kambrick, Siqing Fu, Aung Naing, Vivek Subbiah, George R. Blumenschein, Bonnie S. Glisson, Merrill S. Kies, Apostolia M. Tsimberidou, Jennifer J. Wheler, Ralph G. Zinner, David S. Hong, Razelle Kurzrock,  and Sarina A. Piha-Paul
23227-23238
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Emetine induces chemosensitivity and reduces clonogenicity of acute myeloid leukemia cells

Emetine induces chemosensitivity and reduces clonogenicity of acute myeloid leukemia cells

https://doi.org/10.18632/oncotarget.8096

Josep Maria Cornet-Masana, Daniel Moreno-Martínez, María Carmen Lara-Castillo, Meritxell Nomdedeu, Amaia Etxabe, Niccolò Tesi, Marta Pratcorona, Jordi Esteve,  and Ruth M. Risueño
23239-23250
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Concordance of anaplastic lymphoma kinase (ALK) gene rearrangements between circulating tumor cells and tumor in non-small cell lung cancer

Concordance of anaplastic lymphoma kinase (ALK) gene rearrangements between circulating tumor cells and tumor in non-small cell lung cancer

https://doi.org/10.18632/oncotarget.8136

Chye Ling Tan, Tse Hui Lim, Tony KH Lim, Daniel Shao-Weng Tan, Yong Wei Chua, Mei Kim Ang, Brendan Pang, Chwee Teck Lim, Angela Takano, Alvin Soon-Tiong Lim, Man Chun Leong,  and Wan-Teck Lim
23251-23262
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Meta-analysis of transcriptome data identifies a novel 5-gene pancreatic adenocarcinoma classifier

Meta-analysis of transcriptome data identifies a novel 5-gene pancreatic adenocarcinoma classifier

https://doi.org/10.18632/oncotarget.8139

Manoj K. Bhasin, Kenneth Ndebele, Octavian Bucur, Eric U. Yee, Hasan H. Otu, Jessica Plati, Andrea Bullock, Xuesong Gu, Eduardo Castan, Peng Zhang, Robert Najarian, Maria S. Muraru, Rebecca Miksad, Roya Khosravi-Far,  and Towia A. Libermann
23263-23281
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Depletion of FAP+ cells reduces immunosuppressive cells and improves metabolism and functions CD8+T cells within tumors

Depletion of FAP+ cells reduces immunosuppressive cells and improves metabolism and functions CD8+T cells within tumors

https://doi.org/10.18632/oncotarget.7818

Ying Zhang,  and Hildegund C.J. Ertl
23282-23299
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MAPK1E322K mutation increases head and neck squamous cell carcinoma sensitivity to erlotinib through enhanced secretion of amphiregulin

MAPK1E322K mutation increases head and neck squamous cell carcinoma sensitivity to erlotinib through enhanced secretion of amphiregulin

https://doi.org/10.18632/oncotarget.8188

Yihui Wen, Hua Li, Yan Zeng, Weiping Wen, Kelsey P. Pendleton, Vivian W.Y. Lui, Ann Marie Egloff,  and Jennifer R. Grandis
23300-23311
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Genomic landscape of DNA repair genes in cancer

Genomic landscape of DNA repair genes in cancer

https://doi.org/10.18632/oncotarget.8196

Young Kwang Chae, Jonathan F. Anker, Benedito A. Carneiro, Sunandana Chandra, Jason Kaplan, Aparna Kalyan, Cesar A. Santa-Maria, Leonidas C. Platanias,  and Francis J. Giles
23312-23321
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

β-casein nanovehicles for oral delivery of chemotherapeutic drug combinations overcoming P-glycoprotein-mediated multidrug resistance in human gastric cancer cells

β-casein nanovehicles for oral delivery of chemotherapeutic drug combinations overcoming P-glycoprotein-mediated multidrug resistance in human gastric cancer cells

https://doi.org/10.18632/oncotarget.8019

Maya Bar-Zeev, Yehuda G. Assaraf,  and Yoav D. Livney
23322-23334
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Identification of extracellular vesicle-borne periostin as a feature of muscle-invasive bladder cancer

Identification of extracellular vesicle-borne periostin as a feature of muscle-invasive bladder cancer

https://doi.org/10.18632/oncotarget.8024

Christopher R. Silvers, Yu-Ru Liu, Chia-Hao Wu, Hiroshi Miyamoto, Edward M. Messing,  and Yi-Fen Lee
23335-23345
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Hepatitis B virus PreS2-mutant large surface antigen activates store-operated calcium entry and promotes chromosome instability

Hepatitis B virus PreS2-mutant large surface antigen activates store-operated calcium entry and promotes chromosome instability

https://doi.org/10.18632/oncotarget.8109

Tim Ting-Chung Yen, Anderson Yang, Wen-Tai Chiu, Tian-Neng Li, Lyu-Han Wang, Yi-Hsuan Wu, Hui-Chen Wang, Linyi Chen, Wen-Ching Wang, Wenya Huang, Chien-Wen Chang, Margaret Dah-Tsyr Chang, Meng-Ru Shen, Ih-Jen Su,  and Lily Hui-Ching Wang
23346-23360
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Near infrared photoimmunotherapy with an anti-mesothelin antibody

Near infrared photoimmunotherapy with an anti-mesothelin antibody

https://doi.org/10.18632/oncotarget.8025

Tadanobu Nagaya, Yuko Nakamura, Kazuhide Sato, Yi-Fan Zhang, Min Ni, Peter L. Choyke, Mitchell Ho,  and Hisataka Kobayashi
23361-23369
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

BAY 11-7085 induces glucocorticoid receptor activation and autophagy that collaborate with apoptosis to induce human synovial fibroblast cell death

BAY 11-7085 induces glucocorticoid receptor activation and autophagy that collaborate with apoptosis to induce human synovial fibroblast cell death

https://doi.org/10.18632/oncotarget.8042

Biserka Relic, Edith Charlier, Celine Deroyer, Olivier Malaise, Sophie Neuville, Aline Desoroux, Philippe Gillet, Dominique de Seny,  and Michel G. Malaise
23370-23382
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Cell fate determination in cisplatin resistance and chemosensitization

Cell fate determination in cisplatin resistance and chemosensitization

https://doi.org/10.18632/oncotarget.8110

Khanh V. Luong, Ling Wang, Brett J. Roberts, James K. Wahl III,  and Aimin Peng
23383-23394
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

NF-κB functions as a molecular link between tumor cells and Th1/Tc1 T cells in the tumor microenvironment to exert radiation-mediated tumor suppression

NF-κB functions as a molecular link between tumor cells and Th1/Tc1 T cells in the tumor microenvironment to exert radiation-mediated tumor suppression

https://doi.org/10.18632/oncotarget.8246

Priscilla S. Simon, Kankana Bardhan, May R. Chen, Amy V. Paschall, Chunwan Lu, Roni J. Bollag, Feng-Chong Kong, JianYue Jin, Feng-Ming Kong, Jennifer L. Waller, Raphael E. Pollock,  and Kebin Liu
23395-23415
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

ABCG1 maintains high-grade glioma survival in vitro and in vivo

ABCG1 maintains high-grade glioma survival in vitro and in vivo

https://doi.org/10.18632/oncotarget.8030

Yi-Hsien Chen, Patrick J. Cimino, Jingqin Luo, Sonika Dahiya,  and David H. Gutmann
23416-23424
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Tumor growth suppressive effect of IL-4 through p21-mediated activation of STAT6 in IL-4Rα overexpressed melanoma models

Tumor growth suppressive effect of IL-4 through p21-mediated activation of STAT6 in IL-4Rα overexpressed melanoma models

https://doi.org/10.18632/oncotarget.8111

Hye Lim Lee, Mi Hee Park, Ju Kyoung Song, Yu Yeon Jung, Youngsoo Kim, Kyung Bo Kim, Dae Yeon Hwang, Do Young Yoon, Min Jong Song, Sang Bae Han,  and Jin Tae Hong
23425-23438
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BCL6 modulation of acute lymphoblastic leukemia response to chemotherapy

BCL6 modulation of acute lymphoblastic leukemia response to chemotherapy

https://doi.org/10.18632/oncotarget.8273

William L. Slone, Blake S. Moses, Ian Hare, Rebecca Evans, Debbie Piktel,  and Laura F. Gibson
23439-23453
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Genomic portfolio of Merkel cell carcinoma as determined by comprehensive genomic profiling: implications for targeted therapeutics

Genomic portfolio of Merkel cell carcinoma as determined by comprehensive genomic profiling: implications for targeted therapeutics

https://doi.org/10.18632/oncotarget.8032

Philip R. Cohen, Brett N. Tomson, Sheryl K. Elkin, Erica Marchlik, Jennifer L. Carter,  and Razelle Kurzrock
23454-23467
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Activation of autophagy flux by metformin downregulates cellular FLICE–like inhibitory protein and enhances TRAIL- induced apoptosis

Activation of autophagy flux by metformin downregulates cellular FLICE–like inhibitory protein and enhances TRAIL- induced apoptosis

https://doi.org/10.18632/oncotarget.8048

Uddin MD. Nazim, Ji-Hong Moon, Ju-Hee Lee, You-Jin Lee, Jae-Won Seol, Seong-Kug Eo, John-Hwa Lee,  and Sang-Youel Park
23468-23481
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Role of ADAM17 in invasion and migration of CD133-expressing liver cancer stem cells after irradiation

Role of ADAM17 in invasion and migration of CD133-expressing liver cancer stem cells after irradiation

https://doi.org/10.18632/oncotarget.8112

SungWoo Hong, Wonhee Hur, Jung Eun Choi, Jung-Hee Kim, Daehee Hwang,  and Seung Kew Yoon
23482-23497
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Androgen deprivation therapy sensitizes triple negative breast cancer cells to immune-mediated lysis through androgen receptor independent modulation of osteoprotegerin

Androgen deprivation therapy sensitizes triple negative breast cancer cells to immune-mediated lysis through androgen receptor independent modulation of osteoprotegerin

https://doi.org/10.18632/oncotarget.8274

Anna R. Kwilas, Andressa Ardiani, Sofia R. Gameiro, Jacob Richards, Ashley B. Hall,  and James W. Hodge
23498-23511
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Increased chemoresistance via Snail–Raf kinase inhibitor protein signaling in colorectal cancer in response to a nicotine derivative

Increased chemoresistance via Snail–Raf kinase inhibitor protein signaling in colorectal cancer in response to a nicotine derivative

https://doi.org/10.18632/oncotarget.8049

Tsai-Yu Lee, Chia-Lin Liu, Yun-Ching Chang, Shin Nieh, Yaoh-Shiang Lin, Shu-Wen Jao, Su-Feng Chen,  and Tsung-Yun Liu
23512-23520
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Driver or passenger effects of augmented c-Myc and Cdc20 in gliomagenesis

Driver or passenger effects of augmented c-Myc and Cdc20 in gliomagenesis

https://doi.org/10.18632/oncotarget.8080

Ping Ji, Xinhui Zhou, Qun Liu, Gregory N. Fuller, Lynette M. Phillips,  and Wei Zhang
23521-23529
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GP73 N-glycosylation at Asn144 reduces hepatocellular carcinoma cell motility and invasiveness

GP73 N-glycosylation at Asn144 reduces hepatocellular carcinoma cell motility and invasiveness

https://doi.org/10.18632/oncotarget.8120

Kai Jiang, Wei Li, Qinle Zhang, Guoquan Yan, Kun Guo, Shu Zhang,  and Yinkun Liu
23530-23541
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Effect of sorafenib on cisplatin-based chemoradiation in head and neck cancer cells

Effect of sorafenib on cisplatin-based chemoradiation in head and neck cancer cells

https://doi.org/10.18632/oncotarget.8275

Nikolaus Möckelmann, Thorsten Rieckmann, Chia-Jung Busch, Benjamin Becker, Lisa Gleißner, Konstantin Hoffer, Maria Omniczynski, Leonhard Steinmeister, Simon Laban, Reidar Grénman, Cordula Petersen, Kai Rothkamm, Ekkehard Dikomey, Rainald Knecht,  and Malte Kriegs
23542-23551
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Krüppel-like factor 8 activates the transcription of C-X-C cytokine receptor type 4 to promote breast cancer cell invasion, transendothelial migration and metastasis

Krüppel-like factor 8 activates the transcription of C-X-C cytokine receptor type 4 to promote breast cancer cell invasion, transendothelial migration and metastasis

https://doi.org/10.18632/oncotarget.8083

Debarati Mukherjee, Heng Lu, Lin Yu, Chunjiang He, Satadru K. Lahiri, Tianshu Li,  and Jihe Zhao
23552-23568
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Novel circulating peptide biomarkers for esophageal squamous cell carcinoma revealed by a magnetic bead-based MALDI-TOFMS assay

Novel circulating peptide biomarkers for esophageal squamous cell carcinoma revealed by a magnetic bead-based MALDI-TOFMS assay

https://doi.org/10.18632/oncotarget.8123

Kun Jia, Wei Li, Feng Wang, Haixia Qu, Yuanyuan Qiao, Lanping Zhou, Yulin Sun, Qingwei Ma,  and Xiaohang Zhao
23569-23580
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Progression of benign prostatic hyperplasia is associated with pro-inflammatory mediators and chronic activation of prostate-infiltrating lymphocytes

Progression of benign prostatic hyperplasia is associated with pro-inflammatory mediators and chronic activation of prostate-infiltrating lymphocytes

https://doi.org/10.18632/oncotarget.8051

Melissa M. Norström, Emelie Rådestad, Berit Sundberg, Jonas Mattsson, Lars Henningsohn, Victor Levitsky,  and Michael Uhlin
23581-23593
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

HER2-siRNA delivered by EGFR-specific single chain antibody inhibits NSCLC cell proliferation and tumor growth

HER2-siRNA delivered by EGFR-specific single chain antibody inhibits NSCLC cell proliferation and tumor growth

https://doi.org/10.18632/oncotarget.8053

Yuan Lu, Yuan Wang, Mi Zhang, Li Liu, Fakai Li, Jian Zhang, Mingxiang Ye, Hu Zhao, Jing Zhao, Bo Yan, Angang Yang, Rui Zhang, Xia Li,  and Xinling Ren
23594-23607
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

[Pemetrexed + Sorafenib] lethality is increased by inhibition of ERBB1/2/3-PI3K-NFκB compensatory survival signaling

[Pemetrexed + Sorafenib] lethality is increased by inhibition of ERBB1/2/3-PI3K-NFκB compensatory survival signaling

https://doi.org/10.18632/oncotarget.8281

Laurence Booth, Jane L. Roberts, Mehrad Tavallai, John Chuckalovcak, Daniel K. Stringer, Antonis E. Koromilas, David L. Boone, William P. McGuire, Andrew Poklepovic,  and Paul Dent
23608-23632
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The mTOR inhibitor Everolimus synergizes with the PI3K inhibitor GDC0941 to enhance anti-tumor efficacy in uveal melanoma

The mTOR inhibitor Everolimus synergizes with the PI3K inhibitor GDC0941 to enhance anti-tumor efficacy in uveal melanoma

https://doi.org/10.18632/oncotarget.8054

Nabil Amirouchene-Angelozzi, Estelle Frisch-Dit-Leitz, Guillaume Carita, Ahmed Dahmani, Chloé Raymondie, Géraldine Liot, David Gentien, Fariba Némati, Didier Decaudin, Sergio Roman-Roman,  and Marie Schoumacher
23633-23646
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Associations between serum CA724 and HER2 overexpression among stage II–III resectable gastric cancer patients: an observational study

Associations between serum CA724 and HER2 overexpression among stage II–III resectable gastric cancer patients: an observational study

https://doi.org/10.18632/oncotarget.8145

Xin-Zu Chen, Wei-Han Zhang, Hai-Ning Chen, Jian-Ping Liu, Du He, Yang Liu, Kai Liu, Xiao-Long Chen, Xian-Ming Mo, Zong-Guang Zhou,  and Jian-Kun Hu
23647-23657
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Toll-like receptors 1, 2, 4 and 6 in esophageal epithelium, Barrett’s esophagus, dysplasia and adenocarcinoma

Toll-like receptors 1, 2, 4 and 6 in esophageal epithelium, Barrett’s esophagus, dysplasia and adenocarcinoma

https://doi.org/10.18632/oncotarget.8151

Heikki Huhta, Olli Helminen, Petri P. Lehenkari, Juha Saarnio, Tuomo J. Karttunen,  and Joonas H. Kauppila
23658-23667
Abstract  |  PDF  |  HTML  |  Order a Reprint

MicroRNA-16 sensitizes breast cancer cells to paclitaxel through suppression of IKBKB expression

MicroRNA-16 sensitizes breast cancer cells to paclitaxel through suppression of IKBKB expression

https://doi.org/10.18632/oncotarget.8056

Xueyuan Tang, Long Jin, Peiguo Cao, Ke Cao, Chenghui Huang, Yanwei Luo, Jian Ma, Shourong Shen, Ming Tan, Xiayu Li,  and Ming Zhou
23668-23683
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Escin Ia suppresses the metastasis of triple-negative breast cancer by inhibiting epithelial-mesenchymal transition via down-regulating LOXL2 expression

Escin Ia suppresses the metastasis of triple-negative breast cancer by inhibiting epithelial-mesenchymal transition via down-regulating LOXL2 expression

https://doi.org/10.18632/oncotarget.8152

Yuhui Wang, Xiaotian Xu, Peng Zhao, Bei Tong, Zhifeng Wei,  and Yue Dai
23684-23699
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

SNP-SNP interactions of three new pri-miRNAs with the target gene PGC and multidimensional analysis of H. pylori in the gastric cancer/atrophic gastritis risk in a Chinese population

SNP-SNP interactions of three new pri-miRNAs with the target gene PGC and multidimensional analysis of H. pylori in the gastric cancer/atrophic gastritis risk in a Chinese population

https://doi.org/10.18632/oncotarget.8057

Qian Xu, Ye-feng Wu, Ying Li, Cai-yun He, Li-ping Sun, Jing-wei Liu,  and Yuan Yuan
23700-23714
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

TKI sensitivity patterns of novel kinase-domain mutations suggest therapeutic opportunities for patients with resistant ALK+ tumors

TKI sensitivity patterns of novel kinase-domain mutations suggest therapeutic opportunities for patients with resistant ALK+ tumors

https://doi.org/10.18632/oncotarget.8173

Amit Dipak Amin, Lingxiao Li, Soumya S. Rajan, Vijay Gokhale, Matthew J. Groysman, Praechompoo Pongtornpipat, Edgar O. Tapia, Mengdie Wang,  and Jonathan H. Schatz
23715-23729
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Dormancy activation mechanism of tracheal stem cells

Dormancy activation mechanism of tracheal stem cells

https://doi.org/10.18632/oncotarget.8179

Xin Li, Jing-xian Xu, Xin-Shan Jia, Wen-ya Li, Yi-chen Han, En-hua Wang,  and Fang Li
23730-23739
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The DEK oncogene activates VEGF expression and promotes tumor angiogenesis and growth in HIF-1α-dependent and -independent manners

The DEK oncogene activates VEGF expression and promotes tumor angiogenesis and growth in HIF-1α-dependent and -independent manners

https://doi.org/10.18632/oncotarget.8060

Yanan Zhang, Jie Liu, Shibin Wang, Xiaoli Luo, Yang Li, Zhaohui Lv, Jie Zhu, Jing Lin, Lihua Ding,  and Qinong Ye
23740-23756
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Upregulation of E2F8 promotes cell proliferation and tumorigenicity in breast cancer by modulating G1/S phase transition

Upregulation of E2F8 promotes cell proliferation and tumorigenicity in breast cancer by modulating G1/S phase transition

https://doi.org/10.18632/oncotarget.8121

Liping Ye, Ling Guo, Zhenyu He, Xi Wang, Chuyong Lin, Xin Zhang, Shu Wu, Yong Bao, Qi Yang, Libing Song,  and Huanxin Lin
23757-23771
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Virtual screening-driven repositioning of etoposide as CD44 antagonist in breast cancer cells

Virtual screening-driven repositioning of etoposide as CD44 antagonist in breast cancer cells

https://doi.org/10.18632/oncotarget.8180

Charmina Aguirre‑Alvarado, Aldo Segura‑Cabrera, Inés Velázquez‑Quesada, Miguel A. Hernández‑Esquivel, Carlos A. García‑Pérez, Sandra L. Guerrero‑Rodríguez, Angel J. Ruiz‑Moreno, Andrea Rodríguez‑Moreno, Sonia M. Pérez‑Tapia,  and Marco A. Velasco‑Velázquez
23772-23784
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Activation of TRPV2 and BKCa channels by the LL-37 enantiomers stimulates calcium entry and migration of cancer cells

Activation of TRPV2 and BKCa channels by the LL-37 enantiomers stimulates calcium entry and migration of cancer cells

https://doi.org/10.18632/oncotarget.8122

Audrey Gambade, Sami Zreika, Maxime Guéguinou, Igor Chourpa, Gaëlle Fromont, Ana Maria Bouchet, Julien Burlaud-Gaillard, Marie Potier-Cartereau, Sébastien Roger, Vincent Aucagne, Stéphan Chevalier, Christophe Vandier, Caroline Goupille,  and Günther Weber
23785-23800
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Hypoxia-regulated gene expression explains differences between melanoma cell line-derived xenografts and patient-derived xenografts

Hypoxia-regulated gene expression explains differences between melanoma cell line-derived xenografts and patient-derived xenografts

https://doi.org/10.18632/oncotarget.8181

Joydeep Bhadury, Berglind O. Einarsdottir, Agnieszka Podraza, Roger Olofsson Bagge, Ulrika Stierner, Lars Ny, Marcela Dávila López,  and Jonas A. Nilsson
23801-23811
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The NEDD8-activating enzyme inhibitor MLN4924 induces G2 arrest and apoptosis in T-cell acute lymphoblastic leukemia

The NEDD8-activating enzyme inhibitor MLN4924 induces G2 arrest and apoptosis in T-cell acute lymphoblastic leukemia

https://doi.org/10.18632/oncotarget.8068

Kun Han, Qingyang Wang, Huanling Cao, Guihua Qiu, Junxia Cao, Xin Li, Jing Wang, Beifen Shen,  and Jiyan Zhang
23812-23824
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Two classes of intrahepatic cholangiocarcinoma defined by relative abundance of mutations and copy number alterations

Two classes of intrahepatic cholangiocarcinoma defined by relative abundance of mutations and copy number alterations

https://doi.org/10.18632/oncotarget.8183

Young-Ho Kim, Eun-Kyung Hong, Sun-Young Kong, Sung-Sik Han, Seoung-Hoon Kim, Je-Keun Rhee, Soo-Kyung Hwang, Sang-Jae Park,  and Tae-Min Kim
23825-23836
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

PIM1 destabilization activates a p53-dependent response to ribosomal stress in cancer cells

PIM1 destabilization activates a p53-dependent response to ribosomal stress in cancer cells

https://doi.org/10.18632/oncotarget.8070

Vinay Sagar, Sara Caldarola, Valentina Aria, Valentina Monteleone, Claudia Fuoco, Cesare Gargioli, Stefano Cannata,  and Fabrizio Loreni
23837-23849
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Rnf25/AO7 positively regulates wnt signaling via disrupting Nkd1-Axin inhibitory complex independent of its ubiquitin ligase activity

Rnf25/AO7 positively regulates wnt signaling via disrupting Nkd1-Axin inhibitory complex independent of its ubiquitin ligase activity

https://doi.org/10.18632/oncotarget.8126

Rui Gao, Lin-Qiang Ma, Xiaogang Du, Ting-Ting Zhang, Liang Zhao, Luhong Liu, Jing-Crystal Liu, Fengjin Guo, Zhi Cheng,  and Huizhe Huang
23850-23859
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

IMB-6G, a novel N-substituted sophoridinic acid derivative, induces endoplasmic reticulum stress-mediated apoptosis via activation of IRE1α and PERK signaling

IMB-6G, a novel N-substituted sophoridinic acid derivative, induces endoplasmic reticulum stress-mediated apoptosis via activation of IRE1α and PERK signaling

https://doi.org/10.18632/oncotarget.8184

Na Zhang, Chongwen Bi, Lu Liu, Yueying Dou, Sheng Tang, Weiqiang Pang, Hongbin Deng,  and Danqing Song
23860-23873
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Clinicopathologic characteristics of EGFR, KRAS, and ALK alterations in 6,595 lung cancers

Clinicopathologic characteristics of EGFR, KRAS, and ALK alterations in 6,595 lung cancers

https://doi.org/10.18632/oncotarget.8074

Boram Lee, Taebum Lee, Se-Hoon Lee, Yoon-La Choi,  and Joungho Han
23874-23884
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Inactivation of RASA1 promotes melanoma tumorigenesis via R-Ras activation

Inactivation of RASA1 promotes melanoma tumorigenesis via R-Ras activation

https://doi.org/10.18632/oncotarget.8127

Hyeran Sung, Krishna L. Kanchi, Xue Wang, Kristen S. Hill, Jane L. Messina, Ji-Hyun Lee, Youngchul Kim, Nathan D. Dees, Li Ding, Jamie K. Teer, Shengyu Yang, Amod A. Sarnaik, Vernon K. Sondak, James J. Mulé, Richard K. Wilson, Jeffrey S. Weber,  and Minjung Kim
23885-23896
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Integrated analysis of long non-coding RNAs in human colorectal cancer

Integrated analysis of long non-coding RNAs in human colorectal cancer

https://doi.org/10.18632/oncotarget.8192

Xiaohua Chen, Binjian Liu, Rui Yang, Yong Guo, Feng Li, Lin Wang,  and Hanyang Hu
23897-23908
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

High expression of C-C chemokine receptor 2 associates with poor overall survival in gastric cancer patients after surgical resection

High expression of C-C chemokine receptor 2 associates with poor overall survival in gastric cancer patients after surgical resection

https://doi.org/10.18632/oncotarget.8069

Ruochen Li, Heng Zhang, Hao Liu, Chao Lin, Yifan Cao, Weijuan Zhang, Zhenbin Shen,  and Jiejie Xu
23909-23918
Abstract  |  PDF  |  HTML  |  Order a Reprint

Alterations of tumor microenvironment by carbon monoxide impedes lung cancer growth

Alterations of tumor microenvironment by carbon monoxide impedes lung cancer growth

https://doi.org/10.18632/oncotarget.8081

Zsuzsanna Nemeth, Eva Csizmadia, Lisa Vikstrom, Mailin Li, Kavita Bisht, Alborz Feizi, Sherrie Otterbein, Brian Zuckerbraun, Daniel B. Costa, Pier Paolo Pandolfi, Janos Fillinger, Balazs Döme, Leo E. Otterbein,  and Barbara Wegiel
23919-23932
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Triptolide has anticancer and chemosensitization effects by down-regulating Akt activation through the MDM2/REST pathway in human breast cancer

Triptolide has anticancer and chemosensitization effects by down-regulating Akt activation through the MDM2/REST pathway in human breast cancer

https://doi.org/10.18632/oncotarget.8207

Jing Xiong, Tiefen Su, Zhiling Qu, Qin Yang, Yu Wang, Jiansha Li,  and Sheng Zhou
23933-23946
Abstract  |  PDF  |  HTML  |  Order a Reprint

Role of isoenzyme M2 of pyruvate kinase in urothelial tumorigenesis

Role of isoenzyme M2 of pyruvate kinase in urothelial tumorigenesis

https://doi.org/10.18632/oncotarget.8114

Haiping Zhou, Xing Wang, Lan Mo, Yan Liu, Feng He, Fenglin Zhang, Kuo-How Huang,  and Xue-Ru Wu
23947-23960
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Plasminogen activator inhibitor-1 enhances radioresistance and aggressiveness of non-small cell lung cancer cells

Plasminogen activator inhibitor-1 enhances radioresistance and aggressiveness of non-small cell lung cancer cells

https://doi.org/10.18632/oncotarget.8208

JiHoon Kang, Wanyeon Kim, TaeWoo Kwon, HyeSook Youn, Joong Sun Kim,  and BuHyun Youn
23961-23974
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Distinct effects of SIRT1 in cancer and stromal cells on tumor promotion

Distinct effects of SIRT1 in cancer and stromal cells on tumor promotion

https://doi.org/10.18632/oncotarget.8073

Dong Hoon Shin, Yong-Joon Choi, Peng Jin, Haejin Yoon, Yang-Sook Chun, Hyun-Woo Shin, Ja-Eun Kim,  and Jong-Wan Park
23975-23987
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Armored long non-coding RNA MEG3 targeting EGFR based on recombinant MS2 bacteriophage virus-like particles against hepatocellular carcinoma

Armored long non-coding RNA MEG3 targeting EGFR based on recombinant MS2 bacteriophage virus-like particles against hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.8115

Le Chang, Guojing Wang, Tingting Jia, Lei Zhang, Yulong Li, Yanxi Han, Kuo Zhang, Guigao Lin, Rui Zhang, Jinming Li,  and Lunan Wang
23988-24004
Abstract  |  PDF  |  HTML  |  Order a Reprint

C-terminal truncated hepatitis B virus X protein promotes hepatocellular carcinogenesis through induction of cancer and stem cell-like properties

C-terminal truncated hepatitis B virus X protein promotes hepatocellular carcinogenesis through induction of cancer and stem cell-like properties

https://doi.org/10.18632/oncotarget.8209

Kai-Yu Ng, Stella Chai, Man Tong, Xin-Yuan Guan, Chi-Ho Lin, Yick-Pang Ching, Dan Xie, Alfred Sze-Lok Cheng,  and Stephanie Ma
24005-24017
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Transmembrane adaptor protein PAG1 is a novel tumor suppressor in neuroblastoma

Transmembrane adaptor protein PAG1 is a novel tumor suppressor in neuroblastoma

https://doi.org/10.18632/oncotarget.8116

Saurabh Agarwal, Rajib Ghosh, Zaowen Chen, Anna Lakoma, Preethi H. Gunaratne, Eugene S. Kim,  and Jason M. Shohet
24018-24026
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Discovery and characterization of Isofistularin-3, a marine brominated alkaloid, as a new DNA demethylating agent inducing cell cycle arrest and sensitization to TRAIL in cancer cells

Discovery and characterization of Isofistularin-3, a marine brominated alkaloid, as a new DNA demethylating agent inducing cell cycle arrest and sensitization to TRAIL in cancer cells

https://doi.org/10.18632/oncotarget.8210

Cristina Florean, Michael Schnekenburger, Jin-Young Lee, Kyung Rok Kim, Aloran Mazumder, Sungmi Song, Jae-Myun Kim, Cindy Grandjenette, Jeoung-Gyun Kim, Ah-Young Yoon, Mario Dicato, Kyu-Won Kim, Christo Christov, Byung-Woo Han, Peter Proksch,  and Marc Diederich
24027-24049
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

cRGD inhibits vasculogenic mimicry formation by down-regulating uPA expression and reducing EMT in ovarian cancer

cRGD inhibits vasculogenic mimicry formation by down-regulating uPA expression and reducing EMT in ovarian cancer

https://doi.org/10.18632/oncotarget.8079

Jiao Tang, Jianguo Wang, Lin Fan, Xiaoxuan Li, Na Liu, Wanxian Luo, Jihui Wang, Yifeng Wang,  and Ying Wang
24050-24062
Abstract  |  PDF  |  HTML  |  Order a Reprint

An evolutionarily conserved negative feedback mechanism in the Hippo pathway reflects functional difference between LATS1 and LATS2

An evolutionarily conserved negative feedback mechanism in the Hippo pathway reflects functional difference between LATS1 and LATS2

https://doi.org/10.18632/oncotarget.8211

Gun-Soo Park, Hyangyee Oh, Minchul Kim, Tackhoon Kim, Randy L. Johnson, Kenneth D. Irvine,  and Dae-Sik Lim
24063-24075
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MicroRNA-1229 overexpression promotes cell proliferation and tumorigenicity and activates Wnt/β-catenin signaling in breast cancer

MicroRNA-1229 overexpression promotes cell proliferation and tumorigenicity and activates Wnt/β-catenin signaling in breast cancer

https://doi.org/10.18632/oncotarget.8119

Zhanyao Tan, Haiqing Zheng, Xiangxia Liu, Wenhui Zhang, Jinrong Zhu, Geyan Wu, Lixue Cao, Junwei Song, Shu Wu, Libing Song,  and Jun Li
24076-24087
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Prospective phase II trial of pazopanib plus CapeOX (capecitabine and oxaliplatin) in previously untreated patients with advanced gastric cancer

Prospective phase II trial of pazopanib plus CapeOX (capecitabine and oxaliplatin) in previously untreated patients with advanced gastric cancer

https://doi.org/10.18632/oncotarget.8175

Seung Tae Kim, Jeeyun Lee, Su Jin Lee, Se Hoon Park, Sin-Ho Jung, Young Suk Park, Ho Yeong Lim, Won Ki Kang,  and Joon Oh Park
24088-24096
Abstract  |  PDF  |  HTML  |  Order a Reprint

An individualized prognostic signature and multi‑omics distinction for early stage hepatocellular carcinoma patients with surgical resection

An individualized prognostic signature and multi‑omics distinction for early stage hepatocellular carcinoma patients with surgical resection

https://doi.org/10.18632/oncotarget.8212

Lu Ao, Xuekun Song, Xiangyu Li, Mengsha Tong, You Guo, Jing Li, Hongdong Li, Hao Cai, Mengyao Li, Qingzhou Guan, Haidan Yan,  and Zheng Guo
24097-24110
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Tumor necrosis factor receptor 2-signaling in CD133-expressing cells in renal clear cell carcinoma

Tumor necrosis factor receptor 2-signaling in CD133-expressing cells in renal clear cell carcinoma

https://doi.org/10.18632/oncotarget.8125

Rafia S. Al-Lamki, Jun Wang, Jun Yang, Natalie Burrows, Patrick H. Maxwell, Timothy Eisen, Anne Y. Warren, Sakari Vanharanta, Simon Pacey, Peter Vandenabeele, Jordan S. Pober,  and John R. Bradley
24111-24124
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Targeting the epigenetic readers in Ewing Sarcoma inhibits the oncogenic transcription factor EWS/Fli1

Targeting the epigenetic readers in Ewing Sarcoma inhibits the oncogenic transcription factor EWS/Fli1

https://doi.org/10.18632/oncotarget.8214

Camille Jacques, François Lamoureux, Marc Baud’huin, Lidia Rodriguez Calleja, Thibaut Quillard, Jérôme Amiaud, Franck Tirode, Françoise Rédini, James E. Bradner, Dominique Heymann,  and Benjamin Ory
24125-24140
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Phenylethanolamine N-methyltransferase downregulation is associated with malignant pheochromocytoma/paraganglioma

Phenylethanolamine N-methyltransferase downregulation is associated with malignant pheochromocytoma/paraganglioma

https://doi.org/10.18632/oncotarget.8234

Seung Eun Lee, Ensel Oh, Boram Lee, Yu Jin Kim, Doo-Yi Oh, Kyungsoo Jung, Jong-Sun Choi, Junghan Kim, Sung Joo Kim, Jung Wook Yang, Jungsuk An, Young Lyun Oh,  and Yoon-La Choi
24141-24153
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

DEPTOR promotes survival of cervical squamous cell carcinoma cells and its silencing induces apoptosis through downregulating PI3K/AKT and by up-regulating p38 MAP kinase

DEPTOR promotes survival of cervical squamous cell carcinoma cells and its silencing induces apoptosis through downregulating PI3K/AKT and by up-regulating p38 MAP kinase

https://doi.org/10.18632/oncotarget.8131

Kalanghad Puthankalam Srinivas, Remadevi Viji, Vipin Mohan Dan, Indira Sukumaran Sajitha, Rajappan Prakash, Puthan Valappil Rahul, Thankayyan R. Santhoshkumar, Subhadra Lakshmi,  and Madhavan Radhakrishna Pillai
24154-24171
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Genomic profiling of lung adenocarcinoma patients reveals therapeutic targets and confers clinical benefit when standard molecular testing is negative

Genomic profiling of lung adenocarcinoma patients reveals therapeutic targets and confers clinical benefit when standard molecular testing is negative

https://doi.org/10.18632/oncotarget.8138

Sun Min Lim, Eun Young Kim, Hye Ryun Kim, Siraj M. Ali, Joel R. Greenbowe, Hyo Sup Shim, Hyun Chang, Seungtaek Lim, Soonmyung Paik,  and Byoung Chul Cho
24172-24178
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Hedgehog pathway maintains cell survival under stress conditions, and drives drug resistance in lung adenocarcinoma

Hedgehog pathway maintains cell survival under stress conditions, and drives drug resistance in lung adenocarcinoma

https://doi.org/10.18632/oncotarget.8253

Erh-Hsuan Lin, Yu-Rung Kao, Chih-An Lin, Ting-Yu Kuo, Sheng-Ping Yang, Chiung-Fang Hsu, Teh-Ying Chou, Chao-Chi Ho,  and Cheng-Wen Wu
24179-24193
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Metastatic model of HPV+ oropharyngeal squamous cell carcinoma demonstrates heterogeneity in tumor metastasis

Metastatic model of HPV+ oropharyngeal squamous cell carcinoma demonstrates heterogeneity in tumor metastasis

https://doi.org/10.18632/oncotarget.8254

Daniel W. Vermeer, Joseph D. Coppock, Erliang Zeng, Kimberly M. Lee, William C. Spanos, Michael D. Onken, Ravindra Uppaluri, John H. Lee,  and Paola D. Vermeer
24194-24207
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Survival analysis of patients with advanced-stage nasopharyngeal carcinoma according to the Epstein-Barr virus status

Survival analysis of patients with advanced-stage nasopharyngeal carcinoma according to the Epstein-Barr virus status

https://doi.org/10.18632/oncotarget.8144

Hao Peng, Lei Chen, Yuan Zhang, Rui Guo, Wen-Fei Li, Yan-Ping Mao, Ling-Long Tan, Ying Sun, Fan Zhang, Li-Zhi Liu, Li Tian, Ai-Hua Lin,  and Jun Ma
24208-24216
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Predictive value of angiogenesis-related gene profiling in patients with HER2-negative metastatic breast cancer treated with bevacizumab and weekly paclitaxel

Predictive value of angiogenesis-related gene profiling in patients with HER2-negative metastatic breast cancer treated with bevacizumab and weekly paclitaxel

https://doi.org/10.18632/oncotarget.8128

Marta Mendiola, Virginia Martínez-Marin, Jesús Herranz, Victoria Heredia, Laura Yébenes, Pilar Zamora, Beatriz Castelo, Álvaro Pinto, María Miguel, Esther Díaz, Angelo Gámez, Juan Ángel Fresno, Ana Ramírez de Molina, David Hardisson, Enrique Espinosa,  and Andrés Redondo
24217-24227
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

mTOR inhibition as an adjuvant therapy in a metastatic model of HPV+ HNSCC

mTOR inhibition as an adjuvant therapy in a metastatic model of HPV+ HNSCC

https://doi.org/10.18632/oncotarget.8286

Joseph D. Coppock, Paola D. Vermeer, Daniel W. Vermeer, Kimberly M. Lee, W. Keith Miskimins, William C. Spanos,  and John H. Lee
24228-24241
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Functional role of eukaryotic translation initiation factor 4 gamma 1 (EIF4G1) in NSCLC

Functional role of eukaryotic translation initiation factor 4 gamma 1 (EIF4G1) in NSCLC

https://doi.org/10.18632/oncotarget.8168

Yueyu Cao, Mengdan Wei, Bing Li, Yali Liu, Ying Lu, Zhipeng Tang, Tianbao Lu, Yujiao Yin, Zhiqiang Qin,  and Zengguang Xu
24242-24251
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Landscape of activating cancer mutations in FGFR kinases and their differential responses to inhibitors in clinical use

Landscape of activating cancer mutations in FGFR kinases and their differential responses to inhibitors in clinical use

https://doi.org/10.18632/oncotarget.8132

Harshnira Patani, Tom D. Bunney, Nethaji Thiyagarajan, Richard A. Norman, Derek Ogg, Jason Breed, Paul Ashford, Andrew Potterton, Mina Edwards, Sarah V. Williams, Gary S. Thomson, Camilla S.M. Pang, Margaret A. Knowles, Alexander L. Breeze, Christine Orengo, Chris Phillips,  and Matilda Katan
24252-24268
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

PD-L1 is an independent prognostic predictor in gastric cancer of Western patients

PD-L1 is an independent prognostic predictor in gastric cancer of Western patients

https://doi.org/10.18632/oncotarget.8169

Christine Böger, Hans-Michael Behrens, Micaela Mathiak, Sandra Krüger, Holger Kalthoff,  and Christoph Röcken
24269-24283
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The retinoblastoma protein regulates hypoxia-inducible genetic programs, tumor cell invasiveness and neuroendocrine differentiation in prostate cancer cells

The retinoblastoma protein regulates hypoxia-inducible genetic programs, tumor cell invasiveness and neuroendocrine differentiation in prostate cancer cells

https://doi.org/10.18632/oncotarget.8301

Mark P. Labrecque, Mandeep K. Takhar, Rebecca Nason, Stephanie Santacruz, Kevin J. Tam, Shabnam Massah, Anne Haegert, Robert H. Bell, Manuel Altamirano-Dimas, Colin C. Collins, Frank J.S. Lee, Gratien G. Prefontaine, Michael E. Cox,  and Timothy V. Beischlag
24284-24302
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Multilevel induction of apoptosis by microtubule-interfering inhibitors 4β-S-aromatic heterocyclic podophyllum derivatives causing multi-fold mitochondrial depolarization and PKA signaling pathways in HeLa cells

Multilevel induction of apoptosis by microtubule-interfering inhibitors 4β-S-aromatic heterocyclic podophyllum derivatives causing multi-fold mitochondrial depolarization and PKA signaling pathways in HeLa cells

https://doi.org/10.18632/oncotarget.8147

Ya-Xuan Zhang, Wei Zhao,  and Ya-Jie Tang
24303-24313
Abstract  |  PDF  |  HTML  |  Order a Reprint

Oncogenic protein SALL4 and ZNF217 as prognostic indicators in solid cancers: a meta‑analysis of individual studies

Oncogenic protein SALL4 and ZNF217 as prognostic indicators in solid cancers: a meta‑analysis of individual studies

https://doi.org/10.18632/oncotarget.8237

Ji Cheng, Jinbo Gao, Xiaoming Shuai,  and Kaixiong Tao
24314-24325
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Genomic and epigenomic analysis of high-risk prostate cancer reveals changes in hydroxymethylation and TET1

Genomic and epigenomic analysis of high-risk prostate cancer reveals changes in hydroxymethylation and TET1

https://doi.org/10.18632/oncotarget.8220

Lien Spans, Thomas Van den Broeck, Elien Smeets, Stefan Prekovic, Bernard Thienpont, Diether Lambrechts, R. Jeffrey Karnes, Nicholas Erho, Mohammed Alshalalfa, Elai Davicioni, Christine Helsen, Thomas Gevaert, Lorenzo Tosco, Karin Haustermans, Evelyne Lerut, Steven Joniau,  and Frank Claessens
24326-24338
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Suppressing activity of tributyrin on hepatocarcinogenesis is associated with inhibiting the p53-CRM1 interaction and changing the cellular compartmentalization of p53 protein

Suppressing activity of tributyrin on hepatocarcinogenesis is associated with inhibiting the p53-CRM1 interaction and changing the cellular compartmentalization of p53 protein

https://doi.org/10.18632/oncotarget.8248

Juliana F. Ortega, Aline de Conti, Volodymyr Tryndyak, Kelly S. Furtado, Renato Heidor, Maria Aderuza Horst, Laura Helena Gasparini Fernandes, Paulo Eduardo Latorre Martins Tavares, Marta Pogribna, Svitlana Shpyleva, Frederick A. Beland, Igor P. Pogribny,  and Fernando Salvador Moreno
24339-24347
Abstract  |  PDF  |  HTML  |  Order a Reprint

Eukaryotic translation initiation factor 5A2 regulates the migration and invasion of hepatocellular carcinoma cells via pathways involving reactive oxygen species

Eukaryotic translation initiation factor 5A2 regulates the migration and invasion of hepatocellular carcinoma cells via pathways involving reactive oxygen species

https://doi.org/10.18632/oncotarget.8324

Rong-Rong Liu, Ya-Su Lv, Yue-Xiao Tang, Yan-Fang Wang, Xiao-Ling Chen, Xiao-Xiao Zheng, Shang-Zhi Xie, Ying Cai, Jun Yu,  and Xian-Ning Zhang
24348-24360
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

EGFR mediates hyperlipidemia-induced renal injury via regulating inflammation and oxidative stress: the detrimental role and mechanism of EGFR activation

EGFR mediates hyperlipidemia-induced renal injury via regulating inflammation and oxidative stress: the detrimental role and mechanism of EGFR activation

https://doi.org/10.18632/oncotarget.8222

Qilu Fang, Chunpeng Zou, Peng Zhong, Feng Lin, Weixin Li, Lintao Wang, Yali Zhang, Chao Zheng, Yi Wang, Xiaokun Li,  and Guang Liang
24361-24373
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

ANO1 protein as a potential biomarker for esophageal cancer prognosis and precancerous lesion development prediction

ANO1 protein as a potential biomarker for esophageal cancer prognosis and precancerous lesion development prediction

https://doi.org/10.18632/oncotarget.8223

Li Shang, Jia-Jie Hao, Xue-Ke Zhao, Jian-Zhong He, Zhi-Zhou Shi, Hui-Juan Liu, Li-Fei Wu, Yan-Yi Jiang, Feng Shi, Hai Yang, Yu Zhang, Yi-Zhen Liu, Tong-Tong Zhang, Xin Xu, Yan Cai, Xue-Mei Jia, Min Li, Qi-Min Zhan, En-Min Li, Li-Dong Wang, Wen-Qiang Wei,  and Ming-Rong Wang
24374-24382
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Twist1-related miR-26b-5p suppresses epithelial-mesenchymal transition, migration and invasion by targeting SMAD1 in hepatocellular carcinoma

Twist1-related miR-26b-5p suppresses epithelial-mesenchymal transition, migration and invasion by targeting SMAD1 in hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.8328

Yong Wang, Baocun Sun, Xiulan Zhao, Nan Zhao, Ran Sun, Dongwang Zhu, Yanhui Zhang, Yanlei Li, Qiang Gu, Xueyi Dong, Meili Wang,  and Jindan An
24383-24401
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Prevention of cisplatin-based chemotherapy-induced delayed nausea and vomiting using triple antiemetic regimens: a mixed treatment comparison

Prevention of cisplatin-based chemotherapy-induced delayed nausea and vomiting using triple antiemetic regimens: a mixed treatment comparison

https://doi.org/10.18632/oncotarget.8255

Qi Shi, Wen Li, Hongjia Li, Qiqi Le, Shanshan Liu, Shaoqi Zong, Leizhen Zheng,  and Fenggang Hou
24402-24414
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Functional characterization and anti-cancer action of the clinical phase II cardiac Na+/K+ ATPase inhibitor istaroxime: in vitro and in vivo properties and cross talk with the membrane androgen receptor

Functional characterization and anti-cancer action of the clinical phase II cardiac Na+/K+ ATPase inhibitor istaroxime: in vitro and in vivo properties and cross talk with the membrane androgen receptor

https://doi.org/10.18632/oncotarget.8329

Konstantinos Alevizopoulos, Konstantinos Dimas, Natalia Papadopoulou, Eva-Maria Schmidt, Anna Tsapara, Saad Alkahtani, Sabina Honisch, Kyriakos C. Prousis, Saud Alarifi, Theodora Calogeropoulou, Florian Lang,  and Christos Stournaras
24415-24428
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Nimotuzumab combined with concurrent chemoradiotherapy in locally advanced nasopharyngeal carcinoma: a retrospective analysis

Nimotuzumab combined with concurrent chemoradiotherapy in locally advanced nasopharyngeal carcinoma: a retrospective analysis

https://doi.org/10.18632/oncotarget.8225

Zhi-gang Liu, Yu Zhao, Jiao Tang, Yu-juan Zhou, Wen-juan Yang, Yan-fang Qiu,  and Hui Wang
24429-24435
Abstract  |  PDF  |  HTML  |  Order a Reprint

BM microenvironmental protection of CML cells from imatinib through Stat5/NF-κB signaling and reversal by Wogonin

BM microenvironmental protection of CML cells from imatinib through Stat5/NF-κB signaling and reversal by Wogonin

https://doi.org/10.18632/oncotarget.8332

Xuefen Xu, Xiaobo Zhang, Yicheng Liu, Lin Yang, Shaoliang Huang, Lu Lu, Shuhao Wang, Qinglong Guo,  and Li Zhao
24436-24454
Abstract  |  PDF  |  HTML  |  Order a Reprint

Neuropathy correlated with imbalanced Foxp3/IL-17 in bone marrow microenvironment of patients with acute myeloid leukemia

Neuropathy correlated with imbalanced Foxp3/IL-17 in bone marrow microenvironment of patients with acute myeloid leukemia

https://doi.org/10.18632/oncotarget.8227

Chen Chen, Yan Liu, Mingqiang Hua, Xiaomei Li, Chunyan Ji,  and Daoxin Ma
24455-24465
Abstract  |  PDF  |  HTML  |  Order a Reprint

MicroRNA-421 regulated by HIF-1α promotes metastasis, inhibits apoptosis, and induces cisplatin resistance by targeting E-cadherin and caspase-3 in gastric cancer

MicroRNA-421 regulated by HIF-1α promotes metastasis, inhibits apoptosis, and induces cisplatin resistance by targeting E-cadherin and caspase-3 in gastric cancer

https://doi.org/10.18632/oncotarget.8228

Xiaoxiao Ge, Xinyang Liu, Fengjuan Lin, Peng Li, Kaiyi Liu, Ruixuan Geng, Congqi Dai, Ying Lin, Wenbo Tang, Zheng Wu, Jinjia Chang, Jianwei Lu,  and Jin Li
24466-24482
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Phosphorylation of TOPK at Y74, Y272 by Src increases the stability of TOPK and promotes tumorigenesis of colon

Phosphorylation of TOPK at Y74, Y272 by Src increases the stability of TOPK and promotes tumorigenesis of colon

https://doi.org/10.18632/oncotarget.8231

Juanjuan Xiao, Qiuhong Duan, Zhe Wang, Wei Yan, Huimin Sun, Peipei Xue, Xiaoming Fan, Xiaoyu Zeng, Juan Chen, Chen Shao,  and Feng Zhu
24483-24494
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Adipose microenvironment promotes triple negative breast cancer cell invasiveness and dissemination by producing CCL5

Adipose microenvironment promotes triple negative breast cancer cell invasiveness and dissemination by producing CCL5

https://doi.org/10.18632/oncotarget.8336

Vittoria D'Esposito, Domenico Liguoro, Maria Rosaria Ambrosio, Francesca Collina, Monica Cantile, Rosa Spinelli, Gregory Alexander Raciti, Claudia Miele, Rossella Valentino, Pietro Campiglia, Michelino De Laurentiis, Maurizio Di Bonito, Gerardo Botti, Renato Franco, Francesco Beguinot,  and Pietro Formisano
24495-24509
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

miR-206 regulates cisplatin resistance and EMT in human lung adenocarcinoma cells partly by targeting MET

miR-206 regulates cisplatin resistance and EMT in human lung adenocarcinoma cells partly by targeting MET

https://doi.org/10.18632/oncotarget.8229

Qing-yong Chen, De-min Jiao, Jian Wang, Huizhen Hu, Xiali Tang, Jun Chen, Hao Mou,  and Wei Lu
24510-24526
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Granulocyte macrophage colony-stimulating factor predicts postoperative recurrence of clear-cell renal cell carcinoma

Granulocyte macrophage colony-stimulating factor predicts postoperative recurrence of clear-cell renal cell carcinoma

https://doi.org/10.18632/oncotarget.8235

Yuan Chang, Le Xu, Lin Zhou, Qiang Fu, Zheng Liu, Yuanfeng Yang, Zongming Lin,  and Jiejie Xu
24527-24536
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MiR-206 suppresses epithelial mesenchymal transition by targeting TGF-β signaling in estrogen receptor positive breast cancer cells

MiR-206 suppresses epithelial mesenchymal transition by targeting TGF-β signaling in estrogen receptor positive breast cancer cells

https://doi.org/10.18632/oncotarget.8233

Kai Yin, Wenjin Yin, Yaohui Wang, Liheng Zhou, Yu Liu, Gong Yang, Jianhua Wang,  and Jinsong Lu
24537-24548
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Prognostic implications of PIK3CA amplification in curatively resected liposarcoma

Prognostic implications of PIK3CA amplification in curatively resected liposarcoma

https://doi.org/10.18632/oncotarget.8240

Joo Hoon Kim, Jae Seok Lee, Eo Jin Kim, Kyu Hyun Park, Ki Hyang Kim, Seong Yoon Yi, Han Seong Kim, Yong Jin Cho, Kyoo-Ho Shin, Joong Bae Ahn, Hyuk Hu, Kyung Sik Kim, Young Deuk Choi, Sunghoon Kim, Young Han Lee, Jin-Suck Suh, Sung Hoon Noh, Sun Young Rha,  and Hyo Song Kim
24549-24558
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

miR-31 is distinctively overexpressed in primary male extramammary Paget's disease

miR-31 is distinctively overexpressed in primary male extramammary Paget's disease

https://doi.org/10.18632/oncotarget.8230

Hao Guo, Rui-Qun Qi, Ya-Ni Lv, He-Xiao Wang, Yu-Xiao Hong, Song Zheng, Jiu-Hong Li, Xing-Hua Gao,  and Hong-Duo Chen
24559-24563
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Chronic inflammation-associated genomic instability paves the way for human esophageal carcinogenesis

Chronic inflammation-associated genomic instability paves the way for human esophageal carcinogenesis

https://doi.org/10.18632/oncotarget.8356

Runhua Lin, Chong Zhang, Jiaxuan Zheng, Dongping Tian, Zhijin Lei, Donglin Chen, Zexin Xu,  and Min Su
24564-24571
Abstract  |  PDF  |  HTML  |  Order a Reprint

Fas-associated protein with death domain (FADD) regulates autophagy through promoting the expression of Ras homolog enriched in brain (Rheb) in human breast adenocarcinoma cells

Fas-associated protein with death domain (FADD) regulates autophagy through promoting the expression of Ras homolog enriched in brain (Rheb) in human breast adenocarcinoma cells

https://doi.org/10.18632/oncotarget.8249

Liangqiang He, Yongzhe Ren, Qianqian Zheng, Lu Wang, Yueyang Lai, Shengwen Guan, Xiaoxin Zhang, Rong Zhang, Jie Wang, Dianhua Chen, Yunwen Yang, Hongqin Zhuang, Wei Cheng, Jing Zhang,  and Zi-chun Hua
24572-24584
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Exosomes derived from gefitinib-treated EGFR-mutant lung cancer cells alter cisplatin sensitivity via up-regulating autophagy

Exosomes derived from gefitinib-treated EGFR-mutant lung cancer cells alter cisplatin sensitivity via up-regulating autophagy

https://doi.org/10.18632/oncotarget.8358

Xiao-Qiu Li, Jia-Tao Liu, Lu-Lu Fan, Yu Liu, Liang Cheng, Fang Wang, Han-Qing Yu, Jian Gao, Wei Wei, Hua Wang,  and Guo-Ping Sun
24585-24595
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Analysis of mutational and clinicopathologic characteristics of lung adenocarcinoma with clear cell component

Analysis of mutational and clinicopathologic characteristics of lung adenocarcinoma with clear cell component

https://doi.org/10.18632/oncotarget.8258

Chang Gu, Xufeng Pan, Rui Wang, Yuan Li, Xuxia Shen, Jianxin Shi,  and Haiquan Chen
24596-24603
Abstract  |  PDF  |  HTML  |  Order a Reprint

Multifunctional targeting vinorelbine plus tetrandrine liposomes for treating brain glioma along with eliminating glioma stem cells

Multifunctional targeting vinorelbine plus tetrandrine liposomes for treating brain glioma along with eliminating glioma stem cells

https://doi.org/10.18632/oncotarget.8360

Xue‑tao Li, Wei Tang, Ying Jiang, Xiao‑min Wang, Yan‑hong Wang, Lan Cheng,  and Xian‑sheng Meng
24604-24622
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Proper hepatic pedicle clamping during hepatectomy is associated with improved postoperative long-term prognosis in patients with AJCC stage IIIB hepatocellular carcinoma

Proper hepatic pedicle clamping during hepatectomy is associated with improved postoperative long-term prognosis in patients with AJCC stage IIIB hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.8331

Xiaoqiang Li, Shuang Liu, Hui Li, Lei Guo, Bo Zhang, Zhenhai Lin, Jubo Zhang,  and Qinghai Ye
24623-24632
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Cefradine blocks solar-ultraviolet induced skin inflammation through direct inhibition of T-LAK cell-originated protein kinase

Cefradine blocks solar-ultraviolet induced skin inflammation through direct inhibition of T-LAK cell-originated protein kinase

https://doi.org/10.18632/oncotarget.8260

Xiaoming Fan, Qiuhong Duan, Changshu Ke, Guiping Zhang, Juanjuan Xiao, Dan Wu, Xiaoyu Zeng, Jingwen Chen, Jinguang Guo, Jie Zhou, Fei Shi,  and Feng Zhu
24633-24645
Abstract  |  PDF  |  HTML  |  Order a Reprint

KIF23 is an independent prognostic biomarker in glioma, transcriptionally regulated by TCF-4

KIF23 is an independent prognostic biomarker in glioma, transcriptionally regulated by TCF-4

https://doi.org/10.18632/oncotarget.8261

Lihua Sun, Chuanbao Zhang, Zhengxiang Yang, Yiping Wu, Hongjun Wang, Zhaoshi Bao,  and Tao Jiang
24646-24655
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Prevalence characteristics of high-risk human papillomaviruses in women living in Shanghai with cervical precancerous lesions and cancer

Prevalence characteristics of high-risk human papillomaviruses in women living in Shanghai with cervical precancerous lesions and cancer

https://doi.org/10.18632/oncotarget.8262

Ying Gu, Chenyun Ma, Jue Zou, Yi Zhu, Rong Yang, Yan Xu,  and Yu Zhang
24656-24663
Abstract  |  PDF  |  HTML  |  Order a Reprint

Altered neutrophil immunophenotypes in childhood B‑cell precursor acute lymphoblastic leukemia

Altered neutrophil immunophenotypes in childhood B‑cell precursor acute lymphoblastic leukemia

https://doi.org/10.18632/oncotarget.8369

Elen Oliveira, Thiago S. Bacelar, Juana Ciudad, Maria Cecília M. Ribeiro, Daniela R.N. Garcia, Lukasz Sedek, Simone F. Maia, Daniel B. Aranha, Indyara C. Machado, Arissa Ikeda, Bianca F. Baglioli, Nathalia Lopez‑Duarte, Lisandra A. C. Teixeira, Tomasz Szczepanski, Maria Luiza M. Silva, Marcelo G.P. Land, Alberto Orfao,  and Elaine S. Costa
24664-24676
Abstract  |  PDF  |  HTML  |  Order a Reprint

Epithelial-to-mesenchymal transition leads to loss of EpCAM and different physical properties in circulating tumor cells from metastatic breast cancer

Epithelial-to-mesenchymal transition leads to loss of EpCAM and different physical properties in circulating tumor cells from metastatic breast cancer

https://doi.org/10.18632/oncotarget.8250

Kyung-A Hyun, Gi-Bang Koo, Hyunju Han, Joohyuk Sohn, Wonshik Choi, Seung-Il Kim, Hyo-Il Jung,  and You-Sun Kim
24677-24687
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Expression of epithelial-mesenchymal transition-related genes increases with copy number in multiple cancer types

Expression of epithelial-mesenchymal transition-related genes increases with copy number in multiple cancer types

https://doi.org/10.18632/oncotarget.8371

Min Zhao, Yining Liu,  and Hong Qu
24688-24699
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Progerin impairs chromosome maintenance by depleting CENP-F from metaphase kinetochores in Hutchinson-Gilford progeria fibroblasts

Progerin impairs chromosome maintenance by depleting CENP-F from metaphase kinetochores in Hutchinson-Gilford progeria fibroblasts

https://doi.org/10.18632/oncotarget.8267

Veronika Eisch, Xiang Lu, Diana Gabriel,  and Karima Djabali
24700-24718
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Netrin-1 suppresses the MEK/ERK pathway and ITGB4 in pancreatic cancer

Netrin-1 suppresses the MEK/ERK pathway and ITGB4 in pancreatic cancer

https://doi.org/10.18632/oncotarget.8348

Xi-Zhou An, Zhi-Guo Zhao, Yu-Xuan Luo, Ran Zhang, Xiao-Qiang Tang, De-Long Hao, Xiang Zhao, Xiang Lv,  and De-Pei Liu
24719-24733
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The microRNA-124-iGluR2/3 pathway regulates glucagon release from alpha cells

The microRNA-124-iGluR2/3 pathway regulates glucagon release from alpha cells

https://doi.org/10.18632/oncotarget.8270

Haiyang Zhang, Rui Liu, Ting Deng, Xia Wang, Hongmei Lang, Yanjun Qu, Jingjing Duan, Dingzhi Huang, Guoguang Ying,  and Yi Ba
24734-24743
Abstract  |  PDF  |  HTML  |  Order a Reprint

Predictive value of EGFR overexpression and gene amplification on icotinib efficacy in patients with advanced esophageal squamous cell carcinoma

Predictive value of EGFR overexpression and gene amplification on icotinib efficacy in patients with advanced esophageal squamous cell carcinoma

https://doi.org/10.18632/oncotarget.8271

Xi Wang, Haitao Niu, Qingxia Fan, Ping Lu, Changwu Ma, Wei Liu, Ying Liu, Weiwei Li, Shaoxuan Hu, Yun Ling, Lei Guo, Jianming Ying,  and Jing Huang
24744-24751
Abstract  |  PDF  |  HTML  |  Order a Reprint

Combination of an anti-EGFRvIII antibody CH12 with Rapamycin synergistically inhibits the growth of EGFRvIII+PTENglioblastoma in vivo

Combination of an anti-EGFRvIII antibody CH12 with Rapamycin synergistically inhibits the growth of EGFRvIII+PTENglioblastoma in vivo

https://doi.org/10.18632/oncotarget.8407

Wen Xu, Yanyu Bi, Juan Kong, Jiqin Zhang, Biao Wang, Kesang Li, Mi Tian, Xiaorong Pan, Bizhi Shi, Jianren Gu, Hua Jiang, Xianming Kong,  and Zonghai Li
24752-24765
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A comprehensive repertoire of tRNA-derived fragments in prostate cancer

A comprehensive repertoire of tRNA-derived fragments in prostate cancer

https://doi.org/10.18632/oncotarget.8293

Michael Olvedy, Mauro Scaravilli, Youri Hoogstrate, Tapio Visakorpi, Guido Jenster,  and Elena S. Martens-Uzunova
24766-24777
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

DNA promoter hypermethylation in nipple fluid: a potential tool for early breast cancer detection

DNA promoter hypermethylation in nipple fluid: a potential tool for early breast cancer detection

https://doi.org/10.18632/oncotarget.8352

Jolien S. de Groot, Cathy B. Moelans, Sjoerd G. Elias, Mary Jo Fackler, Robert van Domselaar, Karijn P.M. Suijkerbuijk, Arjen J. Witkamp, Saraswati Sukumar, Paul J. van Diest,  and Elsken van der Wall
24778-24791
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Monocyte chemotactic protein-1 deficiency reduces spontaneous metastasis of Lewis lung carcinoma in mice fed a high-fat diet

Monocyte chemotactic protein-1 deficiency reduces spontaneous metastasis of Lewis lung carcinoma in mice fed a high-fat diet

https://doi.org/10.18632/oncotarget.8364

Lin Yan,  and Sneha Sundaram
24792-24799
Abstract  |  PDF  |  HTML  |  Order a Reprint

Promoter methylation of RNF180 is associated with H.pylori infection and serves as a marker for gastric cancer and atrophic gastritis

Promoter methylation of RNF180 is associated with H.pylori infection and serves as a marker for gastric cancer and atrophic gastritis

https://doi.org/10.18632/oncotarget.8523

Fang Han, Li-ping Sun, Shuang Liu, Qian Xu, Qiao-yi Liang, Zhe Zhang, Hai-chao Cao, Jun Yu, Dai-ming Fan, Yong-zhan Nie, Kai-chun Wu,  and Yuan Yuan
24800-24809
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The tumor-inhibitory effectiveness of a novel anti-Trop2 Fab conjugate in pancreatic cancer

The tumor-inhibitory effectiveness of a novel anti-Trop2 Fab conjugate in pancreatic cancer

https://doi.org/10.18632/oncotarget.8529

Yuan Mao, Xiaoying Wang, Feng Zheng, Changjun Wang, Qi Tang, Xiaojun Tang, Ning Xu, Huiling Zhang, Dawei Zhang, Lin Xiong, Jie Liang,  and Jin Zhu
24810-24823
Abstract  |  PDF  |  HTML  |  Order a Reprint

New insights into the prognostic value of Ki-67 labeling index in patients with triple-negative breast cancer

New insights into the prognostic value of Ki-67 labeling index in patients with triple-negative breast cancer

https://doi.org/10.18632/oncotarget.8531

Shuang Hao, Zhi-Xian He, Ke-Da Yu, Wen-Tao Yang,  and Zhi-Min Shao
24824-24831
Abstract  |  PDF  |  HTML  |  Order a Reprint

G protein γ subunit 7 induces autophagy and inhibits cell division

G protein γ subunit 7 induces autophagy and inhibits cell division

https://doi.org/10.18632/oncotarget.8559

Juanjuan Liu, Xinmiao Ji, Zhiyuan Li, Xingxing Yang, Wenchao Wang,  and Xin Zhang
24832-24847
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Clinical Research Papers

The role of postmastectomy radiotherapy in clinically node-positive, stage II-III breast cancer patients with pathological negative nodes after neoadjuvant chemotherapy: an analysis from the NCDB

The role of postmastectomy radiotherapy in clinically node-positive, stage II-III breast cancer patients with pathological negative nodes after neoadjuvant chemotherapy: an analysis from the NCDB

https://doi.org/10.18632/oncotarget.6664

Jieqiong Liu, Kai Mao, Shuai Jiang, Wen Jiang, Kai Chen, Betty Y.S. Kim, Qiang Liu,  and Lisa K. Jacobs
24848-24859
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Use of dedicated gene panel sequencing using next generation sequencing to improve the personalized care of lung cancer

Use of dedicated gene panel sequencing using next generation sequencing to improve the personalized care of lung cancer

https://doi.org/10.18632/oncotarget.8391

Coureche Guillaume Kaderbhai, Romain Boidot, Françoise Beltjens, Sandy Chevrier, Laurent Arnould, Laure Favier, Aurélie Lagrange, Bruno Coudert,  and François Ghiringhelli
24860-24870
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Sitagliptin use and thyroid cancer risk in patients with type 2 diabetes

Sitagliptin use and thyroid cancer risk in patients with type 2 diabetes

https://doi.org/10.18632/oncotarget.8399

Chin-Hsiao Tseng
24871-24879
Abstract  |  PDF  |  HTML  |  Order a Reprint

Marital status independently predicts pancreatic cancer survival in patients treated with surgical resection: an analysis of the SEER database

Marital status independently predicts pancreatic cancer survival in patients treated with surgical resection: an analysis of the SEER database

https://doi.org/10.18632/oncotarget.8467

Xiao-Dong Wang, Jian-Jun Qian, Dou-Sheng Bai, Zhen-Nan Li, Guo-Qing Jiang,  and Jie Yao
24880-24887
Abstract  |  PDF  |  HTML  |  Order a Reprint

Therapy to target renal cell carcinoma using 131I-labeled B7-H3 monoclonal antibody

Therapy to target renal cell carcinoma using 131I-labeled B7-H3 monoclonal antibody

https://doi.org/10.18632/oncotarget.8550

Gongcheng Wang, Ziyu Wu, Yunyan Wang, Xueqin Li, Guangbo Zhang,  and Jianquan Hou
24888-24898
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint


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