Oncotarget

Vol 7, No 16

April 19, 2016

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A Monoclonal Antibody Against the Wnt Signaling Inhibitor Dickkopf-1 Inhibits Osteosarcoma Metastasis in a Preclinical Model. See Goldstein et al.

Table of Contents

Priority Research Papers

PI3K/Akt promotes feedforward mTORC2 activation through IKKα

PI3K/Akt promotes feedforward mTORC2 activation through IKKα

https://doi.org/10.18632/oncotarget.8383

Han C. Dan, Ricardo J. Antonia,  and Albert S. Baldwin
21064-21075
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Human platelets repurposed as vehicles for in vivo imaging of myeloma xenotransplants

Human platelets repurposed as vehicles for in vivo imaging of myeloma xenotransplants

https://doi.org/10.18632/oncotarget.8517

Lu Dai, Ning Gu, Bao-An Chen,  and Gerard Marriott
21076-21090
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Na+/H+ exchanger NHE1 regulation modulates metastatic potential and epithelial-mesenchymal transition of triple-negative breast cancer cells

Na+/H+ exchanger NHE1 regulation modulates metastatic potential and epithelial-mesenchymal transition of triple-negative breast cancer cells

https://doi.org/10.18632/oncotarget.8520

Schammim Ray Amith, Jodi Marie Wilkinson,  and Larry Fliegel
21091-21113
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A monoclonal antibody against the Wnt signaling inhibitor dickkopf-1 inhibits osteosarcoma metastasis in a preclinical model

A monoclonal antibody against the Wnt signaling inhibitor dickkopf-1 inhibits osteosarcoma metastasis in a preclinical model

https://doi.org/10.18632/oncotarget.8522

Seth D. Goldstein, Matteo Trucco, Wendy Bautista Guzman, Masanori Hayashi,  and David M. Loeb
21114-21123
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Research Papers: Gerotarget (Focus on Aging)

Aging-related elevation of sphingoid bases shortens yeast chronological life span by compromising mitochondrial function

Aging-related elevation of sphingoid bases shortens yeast chronological life span by compromising mitochondrial function

https://doi.org/10.18632/oncotarget.8195

Jae Kyo Yi, Ruijuan Xu, Eunmi Jeong, Izolda Mileva, Jean-Philip Truman, Chih-li Lin, Kai Wang, Justin Snider, Sally Wen, Lina M. Obeid, Yusuf A. Hannun,  and Cungui Mao
21124-21144
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Tissue repair genes: the TiRe database and its implication for skin wound healing

Tissue repair genes: the TiRe database and its implication for skin wound healing

https://doi.org/10.18632/oncotarget.8501

Hagai Yanai, Arie Budovsky, Robi Tacutu, Thomer Barzilay, Amir Abramovich, Rolf Ziesche,  and Vadim E. Fraifeld
21145-21155
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Activation of bitter taste receptors (tas2rs) relaxes detrusor smooth muscle and suppresses overactive bladder symptoms

Activation of bitter taste receptors (tas2rs) relaxes detrusor smooth muscle and suppresses overactive bladder symptoms

https://doi.org/10.18632/oncotarget.8549

Kui Zhai, Zhiguang Yang, Xiaofei Zhu, Eric Nyirimigabo, Yue Mi, Yan Wang, Qinghua Liu, Libo Man, Shiliang Wu, Jie Jin,  and Guangju Ji
21156-21167
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Research Papers: Pathology

A new immunization and treatment strategy for mouse mammary tumor virus (MMTV) associated cancers

A new immunization and treatment strategy for mouse mammary tumor virus (MMTV) associated cancers

https://doi.org/10.18632/oncotarget.7762

Ori Braitbard, Maayan Roniger, Allan Bar-Sinai, Dana Rajchman, Tamar Gross, Hillel Abramovitch, Marco La Ferla, Sara Franceschi, Francesca Lessi, Antonio Giuseppe Naccarato, Chiara M. Mazzanti, Generoso Bevilacqua,  and Jacob Hochman
21168-21180
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Evaluation of p16/Ki-67 dual staining in detection of cervical precancer and cancers: a multicenter study in China

Evaluation of p16/Ki-67 dual staining in detection of cervical precancer and cancers: a multicenter study in China

https://doi.org/10.18632/oncotarget.8307

Lu-Lu Yu, Wen Chen, Xiao-Qin Lei, Yu Qin, Ze-Ni Wu, Qin-Jing Pan, Xun Zhang, Bai-Feng Chang, Shao-Kai Zhang, Hui-Qin Guo,  and You-Lin Qiao
21181-21189
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Ki-67 proliferation index but not mitotic thresholds integrates the molecular prognostic stratification of lower grade gliomas

Ki-67 proliferation index but not mitotic thresholds integrates the molecular prognostic stratification of lower grade gliomas

https://doi.org/10.18632/oncotarget.8498

Eleonora Duregon, Luca Bertero, Alessandra Pittaro, Riccardo Soffietti, Roberta Rudà, Morena Trevisan, Mauro Papotti, Laura Ventura, Rebecca Senetta,  and Paola Cassoni
21190-21198
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Research Papers: Immunology

An optimized single chain TCR scaffold relying on the assembly with the native CD3-complex prevents residual mispairing with endogenous TCRs in human T-cells

An optimized single chain TCR scaffold relying on the assembly with the native CD3-complex prevents residual mispairing with endogenous TCRs in human T-cells

https://doi.org/10.18632/oncotarget.8385

Diana Knies, Sebastian Klobuch, Shao-An Xue, Matthias Birtel, Hakim Echchannaoui, Oezlem Yildiz, Tana Omokoko, Philippe Guillaume, Pedro Romero, Hans Stauss, Ugur Sahin, Wolfgang Herr, Matthias Theobald, Simone Thomas,  and Ralf-Holger Voss
21199-21221
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Liang-Ge-San, a classic traditional Chinese medicine formula, protects against lipopolysaccharide-induced inflammation through cholinergic anti-inflammatory pathway

Liang-Ge-San, a classic traditional Chinese medicine formula, protects against lipopolysaccharide-induced inflammation through cholinergic anti-inflammatory pathway

https://doi.org/10.18632/oncotarget.8452

Jun-Shan Liu, Xi-Duan Wei, Zi-Bin Lu, Pei Xie, Hong-Ling Zhou, Yu-Yao Chen, Jia-Mei Ma,  and Lin-Zhong Yu
21222-21234
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Reviews

Autophagy-associated immune responses and cancer immunotherapy

Autophagy-associated immune responses and cancer immunotherapy

https://doi.org/10.18632/oncotarget.6908

Hongming Pan, Liuxi Chen, Yinghua Xu, Weidong Han, Fang Lou, Weiqiang Fei, Shuiping Liu, Zhao Jing,  and Xinbing Sui
21235-21246
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VEGF pathway targeting agents, vessel normalization and tumor drug uptake: from bench to bedside

VEGF pathway targeting agents, vessel normalization and tumor drug uptake: from bench to bedside

https://doi.org/10.18632/oncotarget.6918

Marlous Arjaans, Carolina P. Schröder, Sjoukje F. Oosting, Urania Dafni, Josée E. Kleibeuker,  and Elisabeth G.E. de Vries
21247-21258
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Beyond evidence-based data: scientific rationale and tumor behavior to drive sequential and personalized therapeutic strategies for the treatment of metastatic renal cell carcinoma

Beyond evidence-based data: scientific rationale and tumor behavior to drive sequential and personalized therapeutic strategies for the treatment of metastatic renal cell carcinoma

https://doi.org/10.18632/oncotarget.7267

Lorena Incorvaia, Giuseppe Bronte, Viviana Bazan, Giuseppe Badalamenti, Sergio Rizzo, Gianni Pantuso, Clara Natoli,  and Antonio Russo
21259-21271
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Research Papers

Identification of cis- and trans-acting elements regulating calretinin expression in mesothelioma cells

Identification of cis- and trans-acting elements regulating calretinin expression in mesothelioma cells

https://doi.org/10.18632/oncotarget.7114

Jelena Kresoja-Rakic, Esra Kapaklikaya, Gabriela Ziltener, Damian Dalcher, Raffaella Santoro, Brock C. Christensen, Kevin C. Johnson, Beat Schwaller, Walter Weder, Rolf A. Stahel,  and Emanuela Felley-Bosco
21272-21286
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Long-term prognostic implications and therapeutic target role of hexokinase II in patients with nasopharyngeal carcinoma

Long-term prognostic implications and therapeutic target role of hexokinase II in patients with nasopharyngeal carcinoma

https://doi.org/10.18632/oncotarget.7116

Meng-Xia Zhang, Yi-Jun Hua, Hai-Yun Wang, Ling Zhou, Hai-Qiang Mai, Xiang Guo, Chong Zhao, Wen-Lin Huang, Ming-Huang Hong,  and Ming-Yuan Chen
21287-21297
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Imprinting defects at human 14q32 locus alters gene expression and is associated with the pathobiology of osteosarcoma

Imprinting defects at human 14q32 locus alters gene expression and is associated with the pathobiology of osteosarcoma

https://doi.org/10.18632/oncotarget.6965

Jingmin Shu, Lihua Li, Anne E. Sarver, Emily A. Pope, Jyotika Varshney, Venugopal Thayanithy, Logan Spector, David A. Largaespada, Clifford J. Steer,  and Subbaya Subramanian
21298-21314
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Metformin inhibits 17β-estradiol-induced epithelial-to-mesenchymal transition via βKlotho-related ERK1/2 signaling and AMPKα signaling in endometrial adenocarcinoma cells

Metformin inhibits 17β-estradiol-induced epithelial-to-mesenchymal transition via βKlotho-related ERK1/2 signaling and AMPKα signaling in endometrial adenocarcinoma cells

https://doi.org/10.18632/oncotarget.7040

Zhao Liu, Shasha Qi, Xingbo Zhao, Mingjiang Li, Sentai Ding, Jiaju Lu,  and Hui Zhang
21315-21331
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Genetic and epigenetic background and protein expression profiles in relation to telomerase activation in medullary thyroid carcinoma

Genetic and epigenetic background and protein expression profiles in relation to telomerase activation in medullary thyroid carcinoma

https://doi.org/10.18632/oncotarget.7237

Na Wang, Hanna Kjellin, Anastasios Sofiadis, Omid Fotouhi, C. Christofer Juhlin, Martin Bäckdah, Jan Zedenius, Dawei Xu, Janne Lehtiö,  and Catharina Larsson
21332-21346
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Survival benefit of surgery with radiotherapy vs surgery alone to patients with T2-3N0M0 stage esophageal adenocarcinoma

Survival benefit of surgery with radiotherapy vs surgery alone to patients with T2-3N0M0 stage esophageal adenocarcinoma

https://doi.org/10.18632/oncotarget.7256

Yaqi Song, Guangzhou Tao, Qing Guo, Xi Yang, Hongcheng Zhu, Wanwei Wang,  and Xinchen Sun
21347-21352
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Molecular spectrum of TP53 mutations in plasma cell dyscrasias by next generation sequencing: an Italian cohort study and overview of the literature

Molecular spectrum of TP53 mutations in plasma cell dyscrasias by next generation sequencing: an Italian cohort study and overview of the literature

https://doi.org/10.18632/oncotarget.7241

Marta Lionetti, Marzia Barbieri, Martina Manzoni, Sonia Fabris, Cecilia Bandini, Katia Todoerti, Filomena Nozza, Davide Rossi, Pellegrino Musto, Luca Baldini,  and Antonino Neri
21353-21361
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EPH/ephrin profile and EPHB2 expression predicts patient survival in breast cancer

EPH/ephrin profile and EPHB2 expression predicts patient survival in breast cancer

https://doi.org/10.18632/oncotarget.7246

Anna-Maria Husa, Željana Magić, Malin Larsson, Tommy Fornander,  and Gizeh Pérez-Tenorio
21362-21380
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Nitrilase 1 modulates lung tumor progression in vitro and in vivo

Nitrilase 1 modulates lung tumor progression in vitro and in vivo

https://doi.org/10.18632/oncotarget.7820

Yong Antican Wang, Yunguang Sun, Justin M. Le Blanc, Charalambos Solomides, Tingting Zhan,  and Bo Lu
21381-21392
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A genetic study and meta-analysis of the genetic predisposition of prostate cancer in a Chinese population

A genetic study and meta-analysis of the genetic predisposition of prostate cancer in a Chinese population

https://doi.org/10.18632/oncotarget.7250

Jacek Marzec, Xueying Mao, Meiling Li, Meilin Wang, Ninghan Feng, Xin Gou, Guomin Wang, Zan Sun, Jianfeng Xu, Hua Xu, Xiaoping Zhang, Shan-Chao Zhao, Guoping Ren, Yongwei Yu, Yudong Wu, Ji Wu, Yao Xue, Bo Zhou, Yanling Zhang, Xingxing Xu, Jie Li, Weiyang He, Sara Benlloch, Helen Ross-Adams, Li Chen, Jucong Li, Yingqia Hong, Zsofia Kote-Jarai, Xingang Cui, Jianguo Hou, Jianming Guo, Lei Xu, Changjun Yin, Yuanping Zhou, David E. Neal, Tim Oliver, Guangwen Cao, Zhengdong Zhang, Douglas F. Easton, Claude Chelala, The PRACTICAL Consortium, The CHIPGECS Group, Ali Amin Al Olama, Rosalind A. Eeles, Hongwei Zhang,  and Yong-Jie Lu
21393-21403
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Knockdown of Golgi phosphoprotein 2 inhibits hepatocellular carcinoma cell proliferation and motility

Knockdown of Golgi phosphoprotein 2 inhibits hepatocellular carcinoma cell proliferation and motility

https://doi.org/10.18632/oncotarget.7271

Yiming Liu, Xiaodi Zhang, Ting Sun, Junchang Jiang, Ying Li, Mingliang Chen, Zhen Wei, Weiqin Jiang,  and Linfu Zhou
21404-21415
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TNFSF10/TRAIL regulates human T4 effector memory lymphocyte radiosensitivity and predicts radiation-induced acute and subacute dermatitis

TNFSF10/TRAIL regulates human T4 effector memory lymphocyte radiosensitivity and predicts radiation-induced acute and subacute dermatitis

https://doi.org/10.18632/oncotarget.7893

Jan Baijer, Nathalie Déchamps, Hervé Perdry, Pablo Morales, Sarah Kerns, Alexandre Vasilescu, Sylvain Baulande, David Azria, Paul Henri Roméo,  and Annette Schmitz
21416-21427
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

RHAMM splice variants confer radiosensitivity in human breast cancer cell lines

RHAMM splice variants confer radiosensitivity in human breast cancer cell lines

https://doi.org/10.18632/oncotarget.7258

Alexandra Schütze, Christian Vogeley, Tobias Gorges, Sören Twarock, Jonas Butschan, Anna Babayan, Diana Klein, Shirley K. Knauer, Eric Metzen, Volkmar Müller, Verena Jendrossek, Klaus Pantel, Karin Milde-Langosch, Jens W. Fischer,  and Katharina Röck
21428-21440
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

mir-329 restricts tumor growth by targeting grb2 in pancreatic cancer

mir-329 restricts tumor growth by targeting grb2 in pancreatic cancer

https://doi.org/10.18632/oncotarget.7375

Xinjing Wang, Xiongxiong Lu, Tian Zhang, Chenlei Wen, Minmin Shi, Xiaomei Tang, Hao Chen, Chenghong Peng, Hongwei Li, Yuan Fang, Xiaxing Deng,  and Baiyong Shen
21441-21453
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

PSMB8 and PBK as potential gastric cancer subtype-specific biomarkers associated with prognosis

PSMB8 and PBK as potential gastric cancer subtype-specific biomarkers associated with prognosis

https://doi.org/10.18632/oncotarget.7411

Chae Hwa Kwon, Hye Ji Park, Yu Ri Choi, Ahrong Kim, Hye Won Kim, Jin Hwa Choi, Chung Su Hwang, So Jung Lee, Chang In Choi, Tae Yong Jeon, Dae Hwan Kim, Gwang Ha Kim,  and Do Youn Park
21454-21468
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Mitochondrial stress controls the radiosensitivity of the oxygen effect: Implications for radiotherapy

Mitochondrial stress controls the radiosensitivity of the oxygen effect: Implications for radiotherapy

https://doi.org/10.18632/oncotarget.7412

Richard B. Richardson,  and Mary-Ellen Harper
21469-21483
Abstract  |  PDF  |  HTML  |  Order a Reprint

(1, 3)-β-D-glucan assay for diagnosing invasive fungal infections in critically ill patients with hematological malignancies

(1, 3)-β-D-glucan assay for diagnosing invasive fungal infections in critically ill patients with hematological malignancies

https://doi.org/10.18632/oncotarget.7471

Elie Azoulay, Nicolas Guigue, Michael Darmon, Djamel Mokart, Virginie Lemiale, Achille Kouatchet, Julien Mayaux, François Vincent, Martine Nyunga, Fabrice Bruneel, Antoine Rabbat, Stéphane Bretagne, Christine Lebert, Anne-Pascale Meert, Dominique Benoit,  and Frédéric Pene
21484-21495
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Overcoming resistance of targeted EGFR monotherapy by inhibition of STAT3 escape pathway in soft tissue sarcoma

Overcoming resistance of targeted EGFR monotherapy by inhibition of STAT3 escape pathway in soft tissue sarcoma

https://doi.org/10.18632/oncotarget.7452

Xiaochun Wang, David Goldstein, Philip J. Crowe, Mark Yang, Kerryn Garrett, Nikolajs Zeps,  and Jia-Lin Yang
21496-21509
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Hsa-miR-329 exerts tumor suppressor function through down-regulation of MET in non-small cell lung cancer

Hsa-miR-329 exerts tumor suppressor function through down-regulation of MET in non-small cell lung cancer

https://doi.org/10.18632/oncotarget.7517

Cheng-Cao Sun, Shu-Jun Li, Feng Zhang, Jing-Yu Pan, Liang Wang, Cui-Li Yang, Yong-Yong Xi,  and De-Jia Li
21510-21526
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Downregulation of 26S proteasome catalytic activity promotes epithelial-mesenchymal transition

Downregulation of 26S proteasome catalytic activity promotes epithelial-mesenchymal transition

https://doi.org/10.18632/oncotarget.7596

Asoka Banno, Daniel A. Garcia, Eric D. van Baarsel, Patrick J. Metz, Kathleen Fisch, Christella E. Widjaja, Stephanie H. Kim, Justine Lopez, Aaron N. Chang, Paul P. Geurink, Bogdan I. Florea, Hermen S. Overkleeft, Huib Ovaa, Jack D. Bui, Jing Yang,  and John T. Chang
21527-21541
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The roles of AKR1C1 and AKR1C2 in ethyl-3,4-dihydroxybenzoate induced esophageal squamous cell carcinoma cell death

The roles of AKR1C1 and AKR1C2 in ethyl-3,4-dihydroxybenzoate induced esophageal squamous cell carcinoma cell death

https://doi.org/10.18632/oncotarget.7775

Wei Li, Guixue Hou, Dianrong Zhou, Xiaomin Lou, Yang Xu, Siqi Liu,  and Xiaohang Zhao
21542-21555
Abstract  |  PDF  |  HTML  |  Order a Reprint

Multi-platform molecular profiling of a large cohort of glioblastomas reveals potential therapeutic strategies

Multi-platform molecular profiling of a large cohort of glioblastomas reveals potential therapeutic strategies

https://doi.org/10.18632/oncotarget.7722

Joanne Xiu, David Piccioni, Tiffany Juarez, Sandeep C. Pingle, Jethro Hu, Jeremy Rudnick, Karen Fink, David B. Spetzler, Todd Maney, Anatole Ghazalpour, Ryan Bender, Zoran Gatalica, Sandeep Reddy, Nader Sanai, Ahmed Idbaih, Michael Glantz,  and Santosh Kesari
21556-21569
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Retrospective analysis on the safety of 5,759 times of bedside hyperthermic intra-peritoneal or intra-pleural chemotherapy (HIPEC)

Retrospective analysis on the safety of 5,759 times of bedside hyperthermic intra-peritoneal or intra-pleural chemotherapy (HIPEC)

https://doi.org/10.18632/oncotarget.7622

Lili Liu, Ning Zhang, Jie Min, Haichuan Su, Hongmei Wang, Dongxu Chen, Li Sun, Hongwei Zhang, Wei Li,  and Helong Zhang
21570-21578
Abstract  |  PDF  |  HTML  |  Order a Reprint

Identification of a six microRNA signature as a novel potential prognostic biomarker in patients with head and neck squamous cell carcinoma

Identification of a six microRNA signature as a novel potential prognostic biomarker in patients with head and neck squamous cell carcinoma

https://doi.org/10.18632/oncotarget.7781

Hao Shi, Jian Chen, Yuncheng Li, Guojun Li, Rong Zhong, Dandan Du, Ruiwei Meng, Weijia Kong,  and Meixia Lu
21579-21590
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Evidence of intermetastatic heterogeneity for pathological response and genetic mutations within colorectal liver metastases following preoperative chemotherapy

Evidence of intermetastatic heterogeneity for pathological response and genetic mutations within colorectal liver metastases following preoperative chemotherapy

https://doi.org/10.18632/oncotarget.7809

Mylène Sebagh, Marc-Antoine Allard, Nelly Bosselut, Myriam Dao, Eric Vibert, Maïté Lewin, Antoinette Lemoine, Daniel Cherqui, René Adam,  and Antonio Sa Cunha
21591-21600
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APIP, an ERBB3-binding partner, stimulates erbB2-3 heterodimer formation to promote tumorigenesis

APIP, an ERBB3-binding partner, stimulates erbB2-3 heterodimer formation to promote tumorigenesis

https://doi.org/10.18632/oncotarget.7802

Se-Hoon Hong, Won Jae Lee, Young Doo Kim, Hyunjoo Kim, Young-Jun Jeon, Bitna Lim, Dong-Hyung Cho, Won Do Heo, Doo-Hyun Yang, Chan-Young Kim, Han-Kwang Yang, Jin Kuk Yang,  and Yong-Keun Jung
21601-21617
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The epigenetic modifier CHD5 functions as a novel tumor suppressor for renal cell carcinoma and is predominantly inactivated by promoter CpG methylation

The epigenetic modifier CHD5 functions as a novel tumor suppressor for renal cell carcinoma and is predominantly inactivated by promoter CpG methylation

https://doi.org/10.18632/oncotarget.7822

Zhenfang Du, Lili Li, Xin Huang, Jie Jin, Suming Huang, Qian Zhang,  and Qian Tao
21618-21630
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

High LEF1 expression predicts adverse prognosis in chronic lymphocytic leukemia and may be targeted by ethacrynic acid

High LEF1 expression predicts adverse prognosis in chronic lymphocytic leukemia and may be targeted by ethacrynic acid

https://doi.org/10.18632/oncotarget.7795

Wei Wu, Huayuan Zhu, Yuan Fu, Wenyi Shen, Kourong Miao, Min Hong, Wei Xu, Lei Fan, Ken H. Young, Peng Liu,  and Jianyong Li
21631-21643
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Hepatic cancer stem cell marker granulin-epithelin precursor and β-catenin expression associate with recurrence in hepatocellular carcinoma

Hepatic cancer stem cell marker granulin-epithelin precursor and β-catenin expression associate with recurrence in hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.7803

Phyllis F.Y. Cheung, Tan To Cheung, Chi Wai Yip, Linda W.C. Ng, Sze Wai Fung, Chung Mau Lo, Sheung Tat Fan,  and Siu Tim Cheung
21644-21657
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Screening of candidate G-quadruplex ligands for the human c-KIT promotorial region and their effects in multiple in-vitro models

Screening of candidate G-quadruplex ligands for the human c-KIT promotorial region and their effects in multiple in-vitro models

https://doi.org/10.18632/oncotarget.7808

Eleonora Zorzan, Silvia Da Ros, Caterina Musetti, Lara Zorro Shahidian, Nuno Filipe Ramos Coelho, Federico Bonsembiante, Sébastien Létard, Maria Elena Gelain, Manlio Palumbo, Patrice Dubreuil, Mery Giantin, Claudia Sissi,  and Mauro Dacasto
21658-21675
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Analysis of plasma microRNA expression profiles revealed different cancer susceptibility in healthy young adult smokers and middle-aged smokers

Analysis of plasma microRNA expression profiles revealed different cancer susceptibility in healthy young adult smokers and middle-aged smokers

https://doi.org/10.18632/oncotarget.7866

Bing Shi, Hongmin Gao, Tianyang Zhang,  and Qinghua Cui
21676-21685
Abstract  |  PDF  |  HTML  |  Order a Reprint

Gene modules associated with breast cancer distant metastasis-free survival in the PAM50 molecular subtypes

Gene modules associated with breast cancer distant metastasis-free survival in the PAM50 molecular subtypes

https://doi.org/10.18632/oncotarget.7774

Rong Liu, Wei Zhang, Zhao-Qian Liu,  and Hong-Hao Zhou
21686-21698
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The paradigm-shifting idea and its practice: from traditional abortion Chinese medicine Murraya paniculata to safe and effective cancer metastatic chemopreventives

The paradigm-shifting idea and its practice: from traditional abortion Chinese medicine Murraya paniculata to safe and effective cancer metastatic chemopreventives

https://doi.org/10.18632/oncotarget.7932

Zhou Jiang, Yaqiong Pang, Xiaobo Yu, Suxia Zhou, Jun Qian, Ning Zheng, Haiyan Dong, Qing Shi, Minliang Kuo,  and Lee Jia
21699-21712
Abstract  |  PDF  |  HTML  |  Order a Reprint

Notch signalling drives bone marrow stromal cell-mediated chemoresistance in acute myeloid leukemia

Notch signalling drives bone marrow stromal cell-mediated chemoresistance in acute myeloid leukemia

https://doi.org/10.18632/oncotarget.7964

Paul Takam Kamga, Giulio Bassi, Adriana Cassaro, Martina Midolo, Mariano Di Trapani, Alessandro Gatti, Roberta Carusone, Federica Resci, Omar Perbellini, Michele Gottardi, Massimiliano Bonifacio, Armel Hervé Nwabo Kamdje, Achille Ambrosetti,  and Mauro Krampera
21713-21727
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

4EGI-1 induces apoptosis and enhances radiotherapy sensitivity in nasopharyngeal carcinoma cells via DR5 induction on 4E-BP1 dephosphorylation

4EGI-1 induces apoptosis and enhances radiotherapy sensitivity in nasopharyngeal carcinoma cells via DR5 induction on 4E-BP1 dephosphorylation

https://doi.org/10.18632/oncotarget.7824

Weiyuan Wang, Jiao Li, Qiuyuan Wen, Jiadi Luo, Shuzhou Chu, Lingjiao Chen, Zhenzhen Qing, Guiyuan Xie, Lina Xu, Mohannad Ma Alnemah, Meirong Li, Songqing Fan,  and Hongbo Zhang
21728-21741
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A prospective study on radiation doses to organs at risk (OARs) during intensity-modulated radiotherapy for nasopharyngeal carcinoma patients

A prospective study on radiation doses to organs at risk (OARs) during intensity-modulated radiotherapy for nasopharyngeal carcinoma patients

https://doi.org/10.18632/oncotarget.7826

Ji-Jin Yao, Fo-Ping Chen, Guan-Qun Zhou, Wang-Jian Zhang, Lin Xu, Xiao-Ju Wang, Li Lin, Jun Ma,  and Ying Sun
21742-21752
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Systematic review with network meta-analysis: statins and risk of hepatocellular carcinoma

Systematic review with network meta-analysis: statins and risk of hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.7832

Yao-Yao Zhou, Gui-Qi Zhu, Yue Wang, Ji-Na Zheng, Lu-Yi Ruan, Zhang Cheng, Bin Hu, Shen-Wen Fu,  and Ming-Hua Zheng
21753-21762
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Oncogene and therapeutic target analyses in atypical fibroxanthomas and pleomorphic dermal sarcomas

Oncogene and therapeutic target analyses in atypical fibroxanthomas and pleomorphic dermal sarcomas

https://doi.org/10.18632/oncotarget.7845

Doris Helbig, Michaela Angelika Ihle, Katharina Pütz, Iliana Tantcheva-Poor, Cornelia Mauch, Reinhard Büttner,  and Alexander Quaas
21763-21774
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DSGOST inhibits tumor growth by blocking VEGF/VEGFR2-activated angiogenesis

DSGOST inhibits tumor growth by blocking VEGF/VEGFR2-activated angiogenesis

https://doi.org/10.18632/oncotarget.7982

Hyeong Sim Choi, Kangwook Lee, Min Kyoung Kim, Kang Min Lee, Yong Cheol Shin, Sung-Gook Cho,  and Seong-Gyu Ko
21775-21785
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Pin1 is required for sustained B cell proliferation upon oncogenic activation of Myc

Pin1 is required for sustained B cell proliferation upon oncogenic activation of Myc

https://doi.org/10.18632/oncotarget.7846

Luana D’Artista, Andrea Bisso, Andrea Piontini, Mirko Doni, Alessandro Verrecchia, Theresia R. Kress, Marco J. Morelli, Giannino Del Sal, Bruno Amati,  and Stefano Campaner
21786-21798
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Phosphatase of regenerating liver-3 inhibits invasiveness and proliferation in non-small cell lung cancer by regulating the epithelial-mesenchymal transition

Phosphatase of regenerating liver-3 inhibits invasiveness and proliferation in non-small cell lung cancer by regulating the epithelial-mesenchymal transition

https://doi.org/10.18632/oncotarget.7985

Sheng‑Yi Lin, Yue‑Xun Lee, Sung‑Liang Yu, Gee‑Chen Chang,  and Jeremy J.W. Chen
21799-21811
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Insights from HuR biology point to potential improvement for second-line ovarian cancer therapy

Insights from HuR biology point to potential improvement for second-line ovarian cancer therapy

https://doi.org/10.18632/oncotarget.7840

Yu-Hung Huang, Weidan Peng, Narumi Furuuchi, James B. DuHadaway, Masaya Jimbo, Andrea Pirritano, Charles J. Dunton, Gary S. Daum, Benjamin E. Leiby, Jonathan R. Brody,  and Janet A. Sawicki
21812-21824
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MicroRNA-543 suppresses colorectal cancer growth and metastasis by targeting KRAS, MTA1 and HMGA2

MicroRNA-543 suppresses colorectal cancer growth and metastasis by targeting KRAS, MTA1 and HMGA2

https://doi.org/10.18632/oncotarget.7989

Chuannan Fan, Yancheng Lin, Yubin Mao, Zhengjie Huang, Allan Yi Liu, Handong Ma, Donghong Yu, Alaiyi Maitikabili, Hongjun Xiao, Chuankai Zhang, Fan Liu, Qi Luo,  and Gaoliang Ouyang
21825-21839
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Exome and deep sequencing of clinically aggressive neuroblastoma reveal somatic mutations that affect key pathways involved in cancer progression

Exome and deep sequencing of clinically aggressive neuroblastoma reveal somatic mutations that affect key pathways involved in cancer progression

https://doi.org/10.18632/oncotarget.8187

Vito Alessandro Lasorsa, Daniela Formicola, Piero Pignataro, Flora Cimmino, Francesco Maria Calabrese, Jaume Mora, Maria Rosaria Esposito, Marcella Pantile, Carlo Zanon, Marilena De Mariano, Luca Longo, Michael D. Hogarty, Carmen de Torres, Gian Paolo Tonini, Achille Iolascon,  and Mario Capasso
21840-21852
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

IL-17A promotes migration and tumor killing capability of B cells in esophageal squamous cell carcinoma

IL-17A promotes migration and tumor killing capability of B cells in esophageal squamous cell carcinoma

https://doi.org/10.18632/oncotarget.7869

Lin Lu, Chengyin Weng, Haibo Mao, Xisheng Fang, Xia Liu, Yong Wu, Xiaofei Cao, Baoxiu Li, Xiaojun Chen, Qinquan Gan, Jianchuan Xia,  and Guolong Liu
21853-21864
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A direct quantification method for measuring plasma MicroRNAs identified potential biomarkers for detecting metastatic breast cancer

A direct quantification method for measuring plasma MicroRNAs identified potential biomarkers for detecting metastatic breast cancer

https://doi.org/10.18632/oncotarget.7990

Qian Zhao, Shengqiong Deng, Guangxue Wang, Cuicui Liu, Lingyu Meng, Shanshan Qiao, Lei Shen, Yue Zhang, Jinhui Lü, Wenshu Li, Yuzhen Zhang, Min Wang, Richard G. Pestell, Chunli Liang,  and Zuoren Yu
21865-21874
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The antihypertensive drug hydralazine activates the intrinsic pathway of apoptosis and causes DNA damage in leukemic T cells

The antihypertensive drug hydralazine activates the intrinsic pathway of apoptosis and causes DNA damage in leukemic T cells

https://doi.org/10.18632/oncotarget.7871

María J. Ruiz-Magaña, Rocío Martínez-Aguilar, Estefanía Lucendo, Diana Campillo-Davo, Klaus Schulze-Osthoff,  and Carmen Ruiz-Ruiz
21875-21886
Abstract  |  PDF  |  HTML  |  Order a Reprint

EVI1 promotes cell proliferation in HBx-induced hepatocarcinogenesis as a critical transcription factor regulating lncRNAs

EVI1 promotes cell proliferation in HBx-induced hepatocarcinogenesis as a critical transcription factor regulating lncRNAs

https://doi.org/10.18632/oncotarget.7993

Jin-feng Huang, Yue Wang, Feng Liu, Yin Liu, Chen-xi Zhao, Ying-jun Guo,  and Shu-han Sun
21887-21899
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

C/EBP homologous protein (CHOP) deficiency ameliorates renal fibrosis in unilateral ureteral obstructive kidney disease

C/EBP homologous protein (CHOP) deficiency ameliorates renal fibrosis in unilateral ureteral obstructive kidney disease

https://doi.org/10.18632/oncotarget.7870

Shing-Hwa Liu, Cheng-Tien Wu, Kuo-How Huang, Ching-Chia Wang, Siao-Syun Guan, Li-Ping Chen,  and Chih-Kang Chiang
21900-21912
Abstract  |  PDF  |  HTML  |  Order a Reprint

Prognostic effect of pregnancy on young female patients with nasopharyngeal carcinoma: results from a matched cohort analysis

Prognostic effect of pregnancy on young female patients with nasopharyngeal carcinoma: results from a matched cohort analysis

https://doi.org/10.18632/oncotarget.8008

Lu Zhang, Huai Liu, Lin-Quan Tang, Qiu-Yan Chen, Shan-Shan Guo, Li-Ting Liu, Ling Guo, Hao-Yuan Mo, Chong Zhao, Xiang Guo, Ka-Jia Cao, Chao-Nan Qian, Mu-Sheng Zeng, Jian-Yong Shao, Ying Sun, Jun Ma, Ming-Huang Hong,  and Hai-Qiang Mai
21913-21921
Abstract  |  PDF  |  HTML  |  Order a Reprint

Increased PTP1B expression and phosphatase activity in colorectal cancer results in a more invasive phenotype and worse patient outcome

Increased PTP1B expression and phosphatase activity in colorectal cancer results in a more invasive phenotype and worse patient outcome

https://doi.org/10.18632/oncotarget.7829

Elmer Hoekstra, Asha M. Das, Marloes Swets, Wanlu Cao, C. Janneke van der Woude, Marco J. Bruno, Maikel P. Peppelenbosch, Peter J.K. Kuppen, Timo L.M. ten Hagen,  and Gwenny M. Fuhler
21922-21938
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Prp19 facilitates invasion of hepatocellular carcinoma via p38 mitogen-activated protein kinase/Twist1 pathway

Prp19 facilitates invasion of hepatocellular carcinoma via p38 mitogen-activated protein kinase/Twist1 pathway

https://doi.org/10.18632/oncotarget.7877

Jie Yin, Lan Wang, Ji-Min Zhu, Qian Yu, Ru-Yi Xue, Ying Fang, Yi-An Zhang, Yan-Jie Chen, Tao-Tao Liu, Ling Dong,  and Xi-Zhong Shen
21939-21951
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Melatonin inhibits TPA-induced oral cancer cell migration by suppressing matrix metalloproteinase-9 activation through the histone acetylation

Melatonin inhibits TPA-induced oral cancer cell migration by suppressing matrix metalloproteinase-9 activation through the histone acetylation

https://doi.org/10.18632/oncotarget.8009

Chia-Ming Yeh, Chiao-Wen Lin, Jia-Sin Yang, Wei-En Yang, Shih-Chi Su,  and Shun-Fa Yang
21952-21967
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Integrin-linked kinase activity modulates the pro-metastatic behavior of ovarian cancer cells

Integrin-linked kinase activity modulates the pro-metastatic behavior of ovarian cancer cells

https://doi.org/10.18632/oncotarget.7880

Lana Bruney, Yueying Liu, Anne Grisoli, Matthew J. Ravosa,  and M. Sharon Stack
21968-21981
Abstract  |  PDF  |  HTML  |  Order a Reprint

Next-generation sequencing for sensitive detection of BCR-ABL1 mutations relevant to tyrosine kinase inhibitor choice in imatinib-resistant patients

Next-generation sequencing for sensitive detection of BCR-ABL1 mutations relevant to tyrosine kinase inhibitor choice in imatinib-resistant patients

https://doi.org/10.18632/oncotarget.8010

Simona Soverini, Caterina De Benedittis, Katerina Machova Polakova, Jana Linhartova, Fausto Castagnetti, Gabriele Gugliotta, Cristina Papayannidis, Manuela Mancini, Hana Klamova, Marzia Salvucci, Monica Crugnola, Alessandra Iurlo, Francesco Albano, Domenico Russo, Gianantonio Rosti, Michele Cavo, Michele Baccarani,  and Giovanni Martinelli
21982-21990
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Activation of hERG3 channel stimulates autophagy and promotes cellular senescence in melanoma

Activation of hERG3 channel stimulates autophagy and promotes cellular senescence in melanoma

https://doi.org/10.18632/oncotarget.7831

Mathew Perez-Neut, Lauren Haar, Vidhya Rao, Sreevidya Santha, Katherine Lansu, Basabi Rana, Walter K. Jones,  and Saverio Gentile
21991-22004
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Activation of the IGF1R pathway potentially mediates acquired resistance to mutant-selective 3rd-generation EGF receptor tyrosine kinase inhibitors in advanced non-small cell lung cancer

Activation of the IGF1R pathway potentially mediates acquired resistance to mutant-selective 3rd-generation EGF receptor tyrosine kinase inhibitors in advanced non-small cell lung cancer

https://doi.org/10.18632/oncotarget.8013

Ji Hyun Park, Yun Jung Choi, Seon Ye Kim, Jung-Eun Lee, Ki Jung Sung, Sojung Park, Woo Sung Kim, Joon Seon Song, Chang-Min Choi, Young Hoon Sung, Jin Kyung Rho,  and Jae Cheol Lee
22005-22015
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Overexpression of USP39 predicts poor prognosis and promotes tumorigenesis of prostate cancer via promoting EGFR mRNA maturation and transcription elongation

Overexpression of USP39 predicts poor prognosis and promotes tumorigenesis of prostate cancer via promoting EGFR mRNA maturation and transcription elongation

https://doi.org/10.18632/oncotarget.7882

Yi Huang, Xiu-Wu Pan, Lin Li, Lu Chen, Xi Liu, Jian-Lei Lu, Xiao-Mei Zhu, Hai Huang, Qi-Wei Yang, Jian-Qing Ye, Si-Shun Gan, Lin-Hui Wang, Yi Hong, Dan-Feng Xu,  and Xin-Gang Cui
22016-22030
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

In-depth analysis of secretome and N-glycosecretome of human hepatocellular carcinoma metastatic cell lines shed light on metastasis correlated proteins

In-depth analysis of secretome and N-glycosecretome of human hepatocellular carcinoma metastatic cell lines shed light on metastasis correlated proteins

https://doi.org/10.18632/oncotarget.8247

Xianyu Li, Jing Jiang, Xinyuan Zhao, Yan Zhao, Qichen Cao, Qing Zhao, Huanhuan Han, Jifeng Wang, Zixiang Yu, Bo Peng, Wantao Ying,  and Xiaohong Qian
22031-22049
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Knock-down of Hdj2/DNAJA1 co-chaperone results in an unexpected burst of tumorigenicity of C6 glioblastoma cells

Knock-down of Hdj2/DNAJA1 co-chaperone results in an unexpected burst of tumorigenicity of C6 glioblastoma cells

https://doi.org/10.18632/oncotarget.7872

Darya A. Meshalkina, Maxim A. Shevtsov, Anatoliy V. Dobrodumov, Elena Y. Komarova, Irina V. Voronkina, Vladimir F. Lazarev, Boris A. Margulis,  and Irina V. Guzhova
22050-22063
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Mutation based treatment recommendations from next generation sequencing data: a comparison of web tools

Mutation based treatment recommendations from next generation sequencing data: a comparison of web tools

https://doi.org/10.18632/oncotarget.8017

Jaymin M. Patel, Joshua Knopf, Eric Reiner, Veerle Bossuyt, Lianne Epstein, Michael DiGiovanna, Gina Chung, Andrea Silber, Tara Sanft, Erin Hofstatter, Sarah Mougalian, Maysa Abu-Khalaf, James Platt, Weiwei Shi, Peter Gershkovich, Christos Hatzis,  and Lajos Pusztai
22064-22076
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The TGF-β pathway is activated by 5-fluorouracil treatment in drug resistant colorectal carcinoma cells

The TGF-β pathway is activated by 5-fluorouracil treatment in drug resistant colorectal carcinoma cells

https://doi.org/10.18632/oncotarget.7895

Gabriele Romano, Ludovica Santi, Maria Rosaria Bianco, Maria Rita Giuffrè, Mariateresa Pettinato, Cristina Bugarin, Cristina Garanzini, Leonilde Savarese, Silvia Leoni, Maria Grazia Cerrito, Biagio Eugenio Leone, Giuseppe Gaipa, Emanuela Grassilli, Michele Papa, Marialuisa Lavitrano,  and Roberto Giovannoni
22077-22091
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MiR-448 promotes glycolytic metabolism of gastric cancer by downregulating KDM2B

MiR-448 promotes glycolytic metabolism of gastric cancer by downregulating KDM2B

https://doi.org/10.18632/oncotarget.8020

Xuehui Hong, Yang Xu, Xingfeng Qiu, Yuekun Zhu, Xing Feng, Zhijie Ding, Shifeng Zhang, Lifeng Zhong, Yifan Zhuang, Chen Su, Xinya Hong,  and Jianchun Cai
22092-22102
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Mutations in histone modulators are associated with prolonged survival during azacitidine therapy

Mutations in histone modulators are associated with prolonged survival during azacitidine therapy

https://doi.org/10.18632/oncotarget.7899

Magnus Tobiasson, Donal P. McLornan, Mohsen Karimi, Marios Dimitriou, Monika Jansson, Asmaa Ben Azenkoud, Martin Jädersten, Greger Lindberg, Hani Abdulkadir, Austin Kulasekararaj, Johanna Ungerstedt, Andreas Lennartsson, Karl Ekwall, Ghulam J. Mufti,  and Eva Hellström-Lindberg
22103-22115
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Chemical chaperon 4-phenylbutyrate protects against the endoplasmic reticulum stress-mediated renal fibrosis in vivo and in vitro

Chemical chaperon 4-phenylbutyrate protects against the endoplasmic reticulum stress-mediated renal fibrosis in vivo and in vitro

https://doi.org/10.18632/oncotarget.7904

Shing-Hwa Liu, Ching-Chin Yang, Ding-Cheng Chan, Cheng-Tien Wu, Li-Ping Chen, Jenq-Wen Huang, Kuan-Yu Hung,  and Chih-Kang Chiang
22116-22127
Abstract  |  PDF  |  HTML  |  Order a Reprint

Identification of differential PI3K pathway target dependencies in T-cell acute lymphoblastic leukemia through a large cancer cell panel screen

Identification of differential PI3K pathway target dependencies in T-cell acute lymphoblastic leukemia through a large cancer cell panel screen

https://doi.org/10.18632/oncotarget.8031

James T. Lynch, Robert McEwen, Claire Crafter, Ultan McDermott, Mathew J. Garnett, Simon T. Barry,  and Barry R. Davies
22128-22139
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Germline genetics of cancer of unknown primary (CUP) and its specific subtypes

Germline genetics of cancer of unknown primary (CUP) and its specific subtypes

https://doi.org/10.18632/oncotarget.7903

Kari Hemminki, Bowang Chen, Abhishek Kumar, Olle Melander, Jonas Manjer, Göran Hallmans, Ulrika Pettersson-Kymmer, Claes Ohlsson, Gunnar Folprecht, Harald Löffler, Alwin Krämer,  and Asta Försti
22140-22149
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Mitochondrial ribosomal protein S18-2 is highly expressed in endometrial cancers along with free E2F1

Mitochondrial ribosomal protein S18-2 is highly expressed in endometrial cancers along with free E2F1

https://doi.org/10.18632/oncotarget.7905

Miriam Mints, Muhammad Mushtaq, Natalia Iurchenko, Larysa Kovalevska, Maria C. Stip, Daria Budnikova, Sonia Andersson, Ludmila Polischuk, Lubov Buchynska,  and Elena Kashuba
22150-22158
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Long noncoding RNA H19 indicates a poor prognosis of colorectal cancer and promotes tumor growth by recruiting and binding to eIF4A3

Long noncoding RNA H19 indicates a poor prognosis of colorectal cancer and promotes tumor growth by recruiting and binding to eIF4A3

https://doi.org/10.18632/oncotarget.8063

Dong Han, Xu Gao, Meng Wang, Yu Qiao, Ya Xu, Jing Yang, Nazhen Dong, Jun He, Qian Sun, Guixiang Lv, Changqing Xu, Ji Tao,  and Ning Ma
22159-22173
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Modulation of chemokines in the tumor microenvironment enhances oncolytic virotherapy for colorectal cancer

Modulation of chemokines in the tumor microenvironment enhances oncolytic virotherapy for colorectal cancer

https://doi.org/10.18632/oncotarget.7907

Lily Francis, Zong Sheng Guo, Zuqiang Liu, Roshni Ravindranathan, Julie A. Urban, Magesh Sathaiah, Deepa Magge, Pawel Kalinski,  and David L. Bartlett
22174-22185
Abstract  |  PDF  |  HTML  |  Order a Reprint

SMAD7 loci contribute to risk of hepatocellular carcinoma and clinicopathologic development among Chinese Han population

SMAD7 loci contribute to risk of hepatocellular carcinoma and clinicopathologic development among Chinese Han population

https://doi.org/10.18632/oncotarget.8065

Jiansong Ji, Min Xu, Zhongwei Zhao, Jianfei Tu, Jun Gao, Chenying Lu, Jingjing Song, Weiqian Chen, Minjiang Chen, Xiaoxi Fan, Xingyao Cheng, Xilin Lan,  and Jie Li
22186-22192
Abstract  |  PDF  |  HTML  |  Order a Reprint

SH2 domain-containing phosphatase 1 regulates pyruvate kinase M2 in hepatocellular carcinoma

SH2 domain-containing phosphatase 1 regulates pyruvate kinase M2 in hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.7923

Wei-Tien Tai, Man-Hsin Hung, Pei-Yi Chu, Yao-Li Chen, Li-Ju Chen, Ming-Hsien Tsai, Min-Husan Chen, Chung-Wai Shiau, Yin-Pin Boo,  and Kuen- Feng Chen
22193-22205
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Small ubiquitin-related modifier 1 is involved in hepatocellular carcinoma progression via mediating p65 nuclear translocation

Small ubiquitin-related modifier 1 is involved in hepatocellular carcinoma progression via mediating p65 nuclear translocation

https://doi.org/10.18632/oncotarget.8066

Jun Liu, Xiaofang Tao, Jin Zhang, Peng Wang, Manqi Sha, Yong Ma, Xiaoping Geng, Lijie Feng, Yujun Shen, Yifan Yu, Siying Wang, Shengyun Fang,  and Yuxian Shen
22206-22218
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Key roles of necroptotic factors in promoting tumor growth

Key roles of necroptotic factors in promoting tumor growth

https://doi.org/10.18632/oncotarget.7924

Xinjian Liu, Min Zhou, Ling Mei, Jiaying Ruan, Qian Hu, Jing Peng, Hang Su, Hong Liao, Shanling Liu, WeiPing Liu, He Wang, Qian Huang, Fang Li,  and Chuan-Yuan Li
22219-22233
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Prognostic roles for fibroblast growth factor receptor family members in malignant peripheral nerve sheath tumor

Prognostic roles for fibroblast growth factor receptor family members in malignant peripheral nerve sheath tumor

https://doi.org/10.18632/oncotarget.8067

Wenya Zhou, Xiaoling Du, Fengju Song, Hong Zheng, Kexin Chen, Wei Zhang,  and Jilong Yang
22234-22244
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Specificity protein (Sp) transcription factors Sp1, Sp3 and Sp4 are non-oncogene addiction genes in cancer cells

Specificity protein (Sp) transcription factors Sp1, Sp3 and Sp4 are non-oncogene addiction genes in cancer cells

https://doi.org/10.18632/oncotarget.7925

Erik Hedrick, Yating Cheng, Un-Ho Jin, Kyounghyun Kim,  and Stephen Safe
22245-22256
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Mutations of KRAS/NRAS/BRAF predict cetuximab resistance in metastatic colorectal cancer patients

Mutations of KRAS/NRAS/BRAF predict cetuximab resistance in metastatic colorectal cancer patients

https://doi.org/10.18632/oncotarget.8076

Hung-Chih Hsu, Tan Kien Thiam, Yen-Jung Lu, Chien Yuh Yeh, Wen-Sy Tsai, Jeng Fu You, Hsin Yuan Hung, Chi-Neu Tsai, An Hsu, Hua-Chien Chen, Shu-Jen Chen,  and Tsai-Sheng Yang
22257-22270
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Systematic meta-analyses of gene-specific genetic association studies in prostate cancer

Systematic meta-analyses of gene-specific genetic association studies in prostate cancer

https://doi.org/10.18632/oncotarget.7926

Qiang Hao, Dong Wei, Yaoguang Zhang, Xin Chen, Fan Yang, Ze Yang, Xiaoquan Zhu,  and Jianye Wang
22271-22284
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

AR-42 induces apoptosis in human hepatocellular carcinoma cells via HDAC5 inhibition

AR-42 induces apoptosis in human hepatocellular carcinoma cells via HDAC5 inhibition

https://doi.org/10.18632/oncotarget.8077

Mingming Zhang, Yida Pan, Robert G. Dorfman, Zhaogui Chen, Fuchen Liu, Qian Zhou, Shan Huang, Jun Zhang, Dongqin Yang,  and Jie Liu
22285-22294
Abstract  |  PDF  |  HTML  |  Order a Reprint

Exploring the role of sphingolipid machinery during the epithelial to mesenchymal transition program using an integrative approach

Exploring the role of sphingolipid machinery during the epithelial to mesenchymal transition program using an integrative approach

https://doi.org/10.18632/oncotarget.7947

Anastasia Meshcheryakova, Martin Svoboda, Ammar Tahir, Harald C. Köfeler, Alexander Triebl, Felicitas Mungenast, Georg Heinze, Christopher Gerner, Philip Zimmermann, Markus Jaritz,  and Diana Mechtcheriakova
22295-22323
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

To treat or not to treat: metabolomics reveals biomarkers for treatment indication in chronic lymphocytic leukaemia patients

To treat or not to treat: metabolomics reveals biomarkers for treatment indication in chronic lymphocytic leukaemia patients

https://doi.org/10.18632/oncotarget.8078

Jaroslaw Piszcz, Emily G. Armitage, Alessia Ferrarini, Francisco J. Rupérez, Agnieszka Kulczynska, Lukasz Bolkun, Janusz Kloczko, Adam Kretowski, Alina Urbanowicz, Michal Ciborowski,  and Coral Barbas
22324-22338
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

miR-101 targeting ZFX suppresses tumor proliferation and metastasis by regulating the MAPK/Erk and Smad pathways in gallbladder carcinoma

miR-101 targeting ZFX suppresses tumor proliferation and metastasis by regulating the MAPK/Erk and Smad pathways in gallbladder carcinoma

https://doi.org/10.18632/oncotarget.7970

Run-Fa Bao, Yi-Jun Shu, Yun-Ping Hu, Xu-An Wang, Fei Zhang, Hai-Bin Liang, Yuan-Yuan Ye, Huai-Feng Li, Shan-Shan Xiang, Hao Weng, Yang Cao, Xiang-Song Wu, Mao-Lan Li, Wen-guang Wu, Yi-Jian Zhang, Lin Jiang, Qian Dong,  and Ying-Bin Liu
22339-22354
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Noninvasive bioluminescence imaging of the dynamics of sanguinarine induced apoptosis via activation of reactive oxygen species

Noninvasive bioluminescence imaging of the dynamics of sanguinarine induced apoptosis via activation of reactive oxygen species

https://doi.org/10.18632/oncotarget.7971

Yan Wang, Beilei Zhang, Wei Liu, Yunpeng Dai, Yaru Shi, Qi Zeng,  and Fu Wang
22355-22367
Abstract  |  PDF  |  HTML  |  Order a Reprint

Systematic evaluation of cancer risk associated with rs2292832 in miR‑149 and rs895819 in miR‑27a: a comprehensive and updated meta‑analysis

Systematic evaluation of cancer risk associated with rs2292832 in miR‑149 and rs895819 in miR‑27a: a comprehensive and updated meta‑analysis

https://doi.org/10.18632/oncotarget.8082

Yajing Feng, Fujiao Duan, Chunhua Song, Xia Zhao, Liping Dai,  and Shuli Cui
22368-22384
Abstract  |  PDF  |  HTML  |  Order a Reprint

Reduced cytosolic carboxypeptidase 6 (CCP6) level leads to accumulation of serum polyglutamylated DNAJC7 protein: A potential biomarker for renal cell carcinoma early detection

Reduced cytosolic carboxypeptidase 6 (CCP6) level leads to accumulation of serum polyglutamylated DNAJC7 protein: A potential biomarker for renal cell carcinoma early detection

https://doi.org/10.18632/oncotarget.8107

Chong Li, Jihan Wang, Junfeng Hao, Baijun Dong, Yi Li, Xiaoxiao Zhu, Juan Ding, Shuangchun Ren, Heping Zhao, Song Wu, Yong Tian,  and Guo-Qing Wang
22385-22396
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Serum Helicobacter pylori FliD antibody and the risk of gastric cancer

Serum Helicobacter pylori FliD antibody and the risk of gastric cancer

https://doi.org/10.18632/oncotarget.7981

Hailin Li, Bing Zhang, Xiaomeng Hu, Yingzi Dong, Qing Fan, Fang Guo, Xiyun Ren, Haibo Zhou, Wenjing Tian,  and Yashuang Zhao
22397-22408
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

In vitro and in vivo anti-tumor activity of CoQ0 against melanoma cells: inhibition of metastasis and induction of cell-cycle arrest and apoptosis through modulation of Wnt/β-catenin signaling pathways

In vitro and in vivo anti-tumor activity of CoQ0 against melanoma cells: inhibition of metastasis and induction of cell-cycle arrest and apoptosis through modulation of Wnt/β-catenin signaling pathways

https://doi.org/10.18632/oncotarget.7983

You-Cheng Hseu, Varadharajan Thiyagarajan, Hsiao-Tung Tsou, Kai-Yuan Lin, Hui-Jye Chen, Chung-Ming Lin, Jiuun-Wang Liao,  and Hsin-Ling Yang
22409-22426
Abstract  |  PDF  |  HTML  |  Order a Reprint

Short- and long-term outcomes in onco-hematological patients admitted to the intensive care unit with classic factors of poor prognosis

Short- and long-term outcomes in onco-hematological patients admitted to the intensive care unit with classic factors of poor prognosis

https://doi.org/10.18632/oncotarget.7986

Etienne Faucher, Martin Cour, Vincent Jahandiez, Adeline Grateau, Thomas Baudry, Romain Hernu, Marie Simon, Jean-michel Robert, Mauricette Michallet,  and Laurent Argaud
22427-22438
Abstract  |  PDF  |  HTML  |  Order a Reprint

Distinguishing epigenetic features of preneoplastic testis tissues adjacent to seminomas and nonseminomas

Distinguishing epigenetic features of preneoplastic testis tissues adjacent to seminomas and nonseminomas

https://doi.org/10.18632/oncotarget.7074

Ildar V. Gainetdinov, Sofia A. Kondratieva, Yulia V. Skvortsova, Marina V. Zinovyeva, Elena A. Stukacheva, Alexey Klimov, Alexey A. Tryakin,  and Tatyana L. Azhikina
22439-22447
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

ChIP-on-chip analysis of thyroid hormone-regulated genes and their physiological significance

ChIP-on-chip analysis of thyroid hormone-regulated genes and their physiological significance

https://doi.org/10.18632/oncotarget.7988

I-Hsiao Chung, Hsuan Liu, Yang-Hsiang Lin, Hsiang-Cheng Chi, Ya-Hui Huang, Chang-Ching Yang, Chau-Ting Yeh, Bertrand Chin-Ming Tan,  and Kwang-Huei Lin
22448-22459
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Pantoprazole, an FDA-approved proton-pump inhibitor, suppresses colorectal cancer growth by targeting T-cell-originated protein kinase

Pantoprazole, an FDA-approved proton-pump inhibitor, suppresses colorectal cancer growth by targeting T-cell-originated protein kinase

https://doi.org/10.18632/oncotarget.7984

Xiaoyu Zeng, Lin Liu, Mengzhu Zheng, Huimin Sun, Juanjuan Xiao, Tao Lu, Guangqian Huang, Pianpian Chen, Jianmin Zhang, Feng Zhu, Hua Li,  and Qiuhong Duan
22460-22473
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MG53 permeates through blood-brain barrier to protect ischemic brain injury

MG53 permeates through blood-brain barrier to protect ischemic brain injury

https://doi.org/10.18632/oncotarget.7965

Yonggang Yao, Bo Zhang, Hua Zhu, Haichang Li, Yu Han, Ken Chen, Zhen Wang, Jing Zeng, Yukai Liu, Xinquan Wang, Yu Li, Duofen He, Peihui Lin, Xinyu Zhou, Ki Ho Park, Zehua Bian, Zhishui Chen, Nianqiao Gong, Tao Tan, Jingsong Zhou, Meng Zhang, Jianjie Ma,  and Chunyu Zeng
22474-22485
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Genetic variants in lncRNA SRA and risk of breast cancer

Genetic variants in lncRNA SRA and risk of breast cancer

https://doi.org/10.18632/oncotarget.7995

Rui Yan, Kaijuan Wang, Rui Peng, Shuaibing Wang, Jingjing Cao, Peng Wang,  and Chunhua Song
22486-22496
Abstract  |  PDF  |  HTML  |  Order a Reprint

Impact of the number of resected lymph nodes on survival after preoperative radiotherapy for esophageal cancer

Impact of the number of resected lymph nodes on survival after preoperative radiotherapy for esophageal cancer

https://doi.org/10.18632/oncotarget.8113

San-Gang Wu, Zhao-Qiang Zhang, Wen-Ming Liu, Zhen-Yu He, Feng-Yan Li, Huan-Xin Lin, Jia-Yuan Sun, Hui Lin,  and Qun Li
22497-22507
Abstract  |  PDF  |  HTML  |  Order a Reprint

Cancer-associated S100P protein binds and inactivates p53, permits therapy-induced senescence and supports chemoresistance

Cancer-associated S100P protein binds and inactivates p53, permits therapy-induced senescence and supports chemoresistance

https://doi.org/10.18632/oncotarget.7999

Adriana Gibadulinova, Michal Pastorek, Pavel Filipcik, Peter Radvak, Lucia Csaderova, Borivoj Vojtesek,  and Silvia Pastorekova
22508-22522
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Is internal target volume accurate for dose evaluation in lung cancer stereotactic body radiotherapy?

Is internal target volume accurate for dose evaluation in lung cancer stereotactic body radiotherapy?

https://doi.org/10.18632/oncotarget.8000

Jiayuan Peng, Zhen Zhang, Jiazhou Wang, Jiang Xie,  and Weigang Hu
22523-22530
Abstract  |  PDF  |  HTML  |  Order a Reprint

In vitro and in vivo effects of a recombinant anti-PSMA immunotoxin in combination with docetaxel against prostate cancer

In vitro and in vivo effects of a recombinant anti-PSMA immunotoxin in combination with docetaxel against prostate cancer

https://doi.org/10.18632/oncotarget.8001

Marta Michalska, Susanne Schultze-Seemann, Lioudmila Bogatyreva, Dieter Hauschke, Ulrich Wetterauer,  and Philipp Wolf
22531-22542
Abstract  |  PDF  |  HTML  |  Order a Reprint

Determination of somatic oncogenic mutations linked to target-based therapies using MassARRAY technology

Determination of somatic oncogenic mutations linked to target-based therapies using MassARRAY technology

https://doi.org/10.18632/oncotarget.8002

Maider Ibarrola-Villava, Tania Fleitas, Marta J. Llorca-Cardeñosa, Cristina Mongort, Elisa Alonso, Samuel Navarro, Octavio Burgues, Ana Vivancos, Juan Miguel Cejalvo, José Alejandro Perez-Fidalgo, Susana Roselló, Gloria Ribas,  and Andrés Cervantes
22543-22555
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Heparanase 2 expression inversely correlates with bladder carcinoma grade and stage

Heparanase 2 expression inversely correlates with bladder carcinoma grade and stage

https://doi.org/10.18632/oncotarget.8003

Miriam Gross-Cohen, Sari Feld, Inna Naroditsky, Ofer Nativ, Neta Ilan,  and Israel Vlodavsky
22556-22565
Abstract  |  PDF  |  HTML  |  Order a Reprint

Non‑invasive prostate cancer detection by measuring miRNA variants (isomiRs) in urine extracellular vesicles

Non‑invasive prostate cancer detection by measuring miRNA variants (isomiRs) in urine extracellular vesicles

https://doi.org/10.18632/oncotarget.8124

Danijela Koppers-Lalic, Michael Hackenberg, Renee de Menezes, Branislav Misovic, Magda Wachalska, Albert Geldof, Nicoletta Zini, Theo de Reijke, Thomas Wurdinger, Andre Vis, Jeroen van Moorselaar, Michiel Pegtel,  and Irene Bijnsdorp
22566-22578
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Dual-targeting triplebody 33-3-19 mediates selective lysis of biphenotypic CD19+ CD33+ leukemia cells

Dual-targeting triplebody 33-3-19 mediates selective lysis of biphenotypic CD19+ CD33+ leukemia cells

https://doi.org/10.18632/oncotarget.8022

Claudia C. Roskopf, Todd A. Braciak, Nadja C. Fenn, Sebastian Kobold, Georg H. Fey, Karl-Peter Hopfner,  and Fuat S. Oduncu
22579-22589
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Regulation of limited N-terminal proteolysis of APE1 in tumor via acetylation and its role in cell proliferation

Regulation of limited N-terminal proteolysis of APE1 in tumor via acetylation and its role in cell proliferation

https://doi.org/10.18632/oncotarget.8026

Kishor K. Bhakat, Shiladitya Sengupta, Victor F. Adeniyi, Shrabasti Roychoudhury, Somsubhra Nath, Larry J. Bellot, Dan Feng, Anil K. Mantha, Mala Sinha, Suimin Qiu,  and Bruce A. Luxon
22590-22604
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Therapy of solid tumors using probiotic Symbioflor-2 – restraints and potential

Therapy of solid tumors using probiotic Symbioflor-2 – restraints and potential

https://doi.org/10.18632/oncotarget.8027

Dino Kocijancic, Sebastian Felgner, Michael Frahm, Ronja-Melinda Komoll, Aida Iljazovic, Vinay Pawar, Manfred Rohde, Ulrike Heise, Kurt Zimmermann, Florian Gunzer, Juliane Hammer, Katja Crull, Sara Leschner,  and Siegfried Weiss
22605-22622
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Oridonin, a novel lysine acetyltransferases inhibitor, inhibits proliferation and induces apoptosis in gastric cancer cells through p53- and caspase-3-mediated mechanisms

Oridonin, a novel lysine acetyltransferases inhibitor, inhibits proliferation and induces apoptosis in gastric cancer cells through p53- and caspase-3-mediated mechanisms

https://doi.org/10.18632/oncotarget.8033

Min Shi, Xiao-Jie Lu, Juan Zhang, Hua Diao, Guangming Li, Ling Xu, Ting Wang, Jue Wei, Wenying Meng, Jia-Li Ma, Heguo Yu,  and Yu-Gang Wang
22623-22631
Abstract  |  PDF  |  HTML  |  Order a Reprint

MicroRNA-related polymorphisms in apoptosis pathway genes are predictive of clinical outcome in patients with limited disease small cell lung cancer

MicroRNA-related polymorphisms in apoptosis pathway genes are predictive of clinical outcome in patients with limited disease small cell lung cancer

https://doi.org/10.18632/oncotarget.8134

Wei Jiang, Nan Bi, Wen-Jue Zhang, Li-Hong Wu, Li-Pin Liu, Yu Men, Jing-Bo Wang, Jun Liang, Zhou-Guang Hui, Zong-Mei Zhou,  and Lu-Hua Wang
22632-22638
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Loss of TINCR expression promotes proliferation, metastasis through activating EpCAM cleavage in colorectal cancer

Loss of TINCR expression promotes proliferation, metastasis through activating EpCAM cleavage in colorectal cancer

https://doi.org/10.18632/oncotarget.8141

Zuo-yang Zhang, Yan-xia Lu, Zhe-ying Zhang, Ya-ya Chang, Lin Zheng, Li Yuan, Fan Zhang, Yu-han Hu, Wen-juan Zhang,  and Xue-nong Li
22639-22649
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Hypoxia-inducible factor 1 alpha is required for the tumourigenic and aggressive phenotype associated with Rab25 expression in ovarian cancer

Hypoxia-inducible factor 1 alpha is required for the tumourigenic and aggressive phenotype associated with Rab25 expression in ovarian cancer

https://doi.org/10.18632/oncotarget.7998

Natividad Gomez-Roman, Neha Mohan Sahasrabudhe, Fiona McGregor, Anthony J. Chalmers, Jim Cassidy,  and Jane Plumb
22650-22664
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Difference in characteristics and outcomes between medullary breast carcinoma and invasive ductal carcinoma: a population based study from SEER 18 database

Difference in characteristics and outcomes between medullary breast carcinoma and invasive ductal carcinoma: a population based study from SEER 18 database

https://doi.org/10.18632/oncotarget.8142

Xiao-Xiao Wang, Yi-Zhou Jiang, Xi-Yu Liu, Jun-Jing Li, Chuan-Gui Song,  and Zhi-Ming Shao
22665-22673
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MicroRNA-630 suppresses tumor metastasis through the TGF-β- miR-630-Slug signaling pathway and correlates inversely with poor prognosis in hepatocellular carcinoma

MicroRNA-630 suppresses tumor metastasis through the TGF-β- miR-630-Slug signaling pathway and correlates inversely with poor prognosis in hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.8047

Wei-xun Chen, Zhan-guo Zhang, Ze-yang Ding, Hui-fang Liang, Jia Song, Xiao-long Tan, Jing-jing Wu, Guang-zhen Li, Zhuo Zeng, Bi-xiang Zhang,  and Xiao-ping Chen
22674-22686
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

DDX3 enhances oncogenic KRAS‑induced tumor invasion in colorectal cancer via the β‑catenin/ZEB1 axis

DDX3 enhances oncogenic KRAS‑induced tumor invasion in colorectal cancer via the β‑catenin/ZEB1 axis

https://doi.org/10.18632/oncotarget.8143

De‑Wei Wu, Po‑Lin Lin, Ya‑Wen Cheng, Chi‑Chou Huang, Lee Wang,  and Huei Lee
22687-22699
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Challenges in detecting pre-malignant pancreatic lesions during acute pancreatitis using a serum microRNA assay: a study based on KrasG12D transgenic mice

Challenges in detecting pre-malignant pancreatic lesions during acute pancreatitis using a serum microRNA assay: a study based on KrasG12D transgenic mice

https://doi.org/10.18632/oncotarget.8148

Xiafei Hong, Jie Zhang, Qiao Wu, Wenze Wang, Adam Yongxin Ye, Wei Song, Hongmei Dai, Xianze Wang, Fan Wu, Lei You, Wenming Wu,  and Yupei Zhao
22700-22710
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Radiation dose escalation by simultaneous modulated accelerated radiotherapy combined with chemotherapy for esophageal cancer: a phase II study

Radiation dose escalation by simultaneous modulated accelerated radiotherapy combined with chemotherapy for esophageal cancer: a phase II study

https://doi.org/10.18632/oncotarget.8050

Jianzhou Chen, Hong Guo, Tiantian Zhai, Daniel Chang, Zhijian Chen, Ruihong Huang, Wuzhe Zhang, Kun Lin, Longjia Guo, Mingzhen Zhou, Dongsheng Li, Derui Li,  and Chuangzhen Chen
22711-22719
Abstract  |  PDF  |  HTML  |  Order a Reprint

A novel prognostic score model incorporating CDGSH iron sulfur domain2 (CISD2) predicts risk of disease progression in laryngeal squamous cell carcinoma

A novel prognostic score model incorporating CDGSH iron sulfur domain2 (CISD2) predicts risk of disease progression in laryngeal squamous cell carcinoma

https://doi.org/10.18632/oncotarget.8150

Lin Yang, Shaodong Hong, Yan Wang, Zhenyu He, Shaobo Liang, Haiyang Chen, Shasha He, Shu Wu, Libing Song,  and Yong Chen
22720-22732
Abstract  |  PDF  |  HTML  |  Order a Reprint

Antitumor activity and inhibitory effects on cancer stem cell-like properties of Adeno-associated virus (AAV) -mediated Bmi-1 interference driven by Bmi-1 promoter for gastric cancer

Antitumor activity and inhibitory effects on cancer stem cell-like properties of Adeno-associated virus (AAV) -mediated Bmi-1 interference driven by Bmi-1 promoter for gastric cancer

https://doi.org/10.18632/oncotarget.8174

Xiaowei Zhang, Weijian Guo, Xiaofeng Wang, Xinyang Liu, Mingzhu Huang, Lu Gan, Yufan Cheng,  and Jin Li
22733-22745
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Association of HMGCR polymorphism with late-onset Alzheimer′s disease in Han Chinese

Association of HMGCR polymorphism with late-onset Alzheimer′s disease in Han Chinese

https://doi.org/10.18632/oncotarget.8176

Xiao-Long Chang, Lin Tan, Meng-Shan Tan, Hui-Fu Wang, Chen-Chen Tan, Wei Zhang, Zhan-Jie Zheng, Ling-Li Kong, Zi-Xuan Wang, Teng Jiang, Jin-Tai Yu,  and Lan Tan
22746-22751
Abstract  |  PDF  |  HTML  |  Order a Reprint

Epigenetic alterations leading to TMPRSS4 promoter hypomethylation and protein overexpression predict poor prognosis in squamous lung cancer patients

Epigenetic alterations leading to TMPRSS4 promoter hypomethylation and protein overexpression predict poor prognosis in squamous lung cancer patients

https://doi.org/10.18632/oncotarget.8045

Maria Villalba, Angel Diaz-Lagares, Miriam Redrado, Arrate L. de Aberasturi, Victor Segura, Maria Elena Bodegas, Maria J. Pajares, Ruben Pio, Javier Freire, Javier Gomez-Roman, Luis M. Montuenga, Manel Esteller, Juan Sandoval,  and Alfonso Calvo
22752-22769
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

LMO1 gene polymorphisms contribute to decreased neuroblastoma susceptibility in a Southern Chinese population

LMO1 gene polymorphisms contribute to decreased neuroblastoma susceptibility in a Southern Chinese population

https://doi.org/10.18632/oncotarget.8178

Jing He, Wei Zhong, Jixiao Zeng, Jinhong Zhu, Ruizhong Zhang, Fenghua Wang, Tianyou Yang, Yan Zou,  and Huimin Xia
22770-22778
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

ATP7B expression confers multidrug resistance through drug sequestration

ATP7B expression confers multidrug resistance through drug sequestration

https://doi.org/10.18632/oncotarget.8059

F M Moinuddin, Yoshinari Shinsato, Masaharu Komatsu, Ryoichi Mitsuo, Kentaro Minami, Masatatsu Yamamoto, Kohich Kawahara, Hirofumi Hirano, Kazunori Arita,  and Tatsuhiko Furukawa
22779-22790
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Loss of miR-449a in ERG-associated prostate cancer promotes the invasive phenotype by inducing SIRT1

Loss of miR-449a in ERG-associated prostate cancer promotes the invasive phenotype by inducing SIRT1

https://doi.org/10.18632/oncotarget.8061

Parameet Kumar, Shashwat Sharad, Gyorgy Petrovics, Ahmed Mohamed, Albert Dobi, Taduru L. Sreenath, Shiv Srivastava,  and Roopa Biswas
22791-22806
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

TAB3 O-GlcNAcylation promotes metastasis of triple negative breast cancer

TAB3 O-GlcNAcylation promotes metastasis of triple negative breast cancer

https://doi.org/10.18632/oncotarget.8182

Tao Tao, Zhixian He, Zhiming Shao,  and Haojie Lu
22807-22818
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Features specific to retinal pigment epithelium cells derived from three-dimensional human embryonic stem cell cultures — a new donor for cell therapy

Features specific to retinal pigment epithelium cells derived from three-dimensional human embryonic stem cell cultures — a new donor for cell therapy

https://doi.org/10.18632/oncotarget.8185

Wei Wu, Yuxiao Zeng, Zhengya Li, Qiyou Li, Haiwei Xu,  and Zheng Qin Yin
22819-22833
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

High leukocyte mtDNA content contributes to poor prognosis through ROS-mediated immunosuppression in hepatocellular carcinoma patients

High leukocyte mtDNA content contributes to poor prognosis through ROS-mediated immunosuppression in hepatocellular carcinoma patients

https://doi.org/10.18632/oncotarget.8071

Xianli He, Falin Qu, Feng Zhou, Xingchun Zhou, Yibing Chen, Xu Guo, Jibin Li, Qichao Huang, Yefa Yang, Zhuomin Lyu, Hongxin Zhang,  and Jinliang Xing
22834-22845
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Automethylation of SUV39H2, an oncogenic histone lysine methyltransferase, regulates its binding affinity to substrate proteins

Automethylation of SUV39H2, an oncogenic histone lysine methyltransferase, regulates its binding affinity to substrate proteins

https://doi.org/10.18632/oncotarget.8072

Lianhua Piao, Makoto Nakakido, Takehiro Suzuki, Naoshi Dohmae, Yusuke Nakamura,  and Ryuji Hamamoto
22846-22856
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Analysis of ultra-deep targeted sequencing reveals mutation burden is associated with gender and clinical outcome in lung adenocarcinoma

Analysis of ultra-deep targeted sequencing reveals mutation burden is associated with gender and clinical outcome in lung adenocarcinoma

https://doi.org/10.18632/oncotarget.8213

Dakai Xiao, Hui Pan, Fuqiang Li, Kui Wu, Xin Zhang,  and Jianxing He
22857-22864
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

In silico analyses identify gene-sets, associated with clinical outcome in ovarian cancer: role of mitotic kinases

In silico analyses identify gene-sets, associated with clinical outcome in ovarian cancer: role of mitotic kinases

https://doi.org/10.18632/oncotarget.8118

Alberto Ocaña, Javier Pérez-Peña, Ana Alcaraz-Sanabria, Verónica Sánchez- Corrales, Cristina Nieto-Jiménez, Arnoud J. Templeton, Bostjan Seruga, Atanasio Pandiella,  and Eitan Amir
22865-22872
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Blockage of autophagy pathway enhances Salmonella tumor-targeting

Blockage of autophagy pathway enhances Salmonella tumor-targeting

https://doi.org/10.18632/oncotarget.8251

Binghong Liu, Yanan Jiang, Tiangeng Dong, Ming Zhao, Jianfu Wu, Lihui Li, Yiwei Chu, Shangyang She, Hu Zhao, Robert M. Hoffman,  and Lijun Jia
22873-22882
Abstract  |  PDF  |  HTML  |  Order a Reprint

Cellular apoptosis susceptibility (CAS) is linked to integrin β1 and required for tumor cell migration and invasion in hepatocellular carcinoma (HCC)

Cellular apoptosis susceptibility (CAS) is linked to integrin β1 and required for tumor cell migration and invasion in hepatocellular carcinoma (HCC)

https://doi.org/10.18632/oncotarget.8256

Juliane Winkler, Stephanie Roessler, Carsten Sticht, Amanda L. DiGuilio, Elisabeth Drucker, Kerstin Holzer, Eva Eiteneuer, Esther Herpel, Kai Breuhahn, Norbert Gretz, Peter Schirmacher, Alessandro Ori,  and Stephan Singer
22883-22892
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Enhancing DPYSL3 gene expression via a promoter-targeted small activating RNA approach suppresses cancer cell motility and metastasis

Enhancing DPYSL3 gene expression via a promoter-targeted small activating RNA approach suppresses cancer cell motility and metastasis

https://doi.org/10.18632/oncotarget.8290

Changlin Li, Wencong Jiang, Qingting Hu, Long-cheng Li, Liang Dong, Ruibao Chen, Yinghong Zhang, Yuzhe Tang, J. Brantley Thrasher, Chang-Bai Liu,  and Benyi Li
22893-22910
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Clinical Research Papers

Decreased MALL expression negatively impacts colorectal cancer patient survival

Decreased MALL expression negatively impacts colorectal cancer patient survival

https://doi.org/10.18632/oncotarget.8094

Xiaoliang Wang, Junwei Fan, Fudong Yu, Feifei Cui, Xing Sun, Lin Zhong, Dongwang Yan, Chongzhi Zhou, Guilong Deng, Bin Wang, Xiaosheng Qi, Shuyun Wang, Lei Qu, Biao Deng, Ming Pan, Jian Chen, Yupeng Wang, Guohe Song, Huamei Tang, Zongguang Zhou,  and Zhihai Peng
22911-22927
Abstract  |  PDF  |  HTML  |  Order a Reprint

A phase I study of indoximod in patients with advanced malignancies

A phase I study of indoximod in patients with advanced malignancies

https://doi.org/10.18632/oncotarget.8216

Hatem H. Soliman, Susan E. Minton, Hyo Sook Han, Roohi Ismail-Khan, Anthony Neuger, Fatema Khambati, David Noyes, Richard Lush, Alberto A. Chiappori, John D. Roberts, Charles Link, Nicholas N. Vahanian, Mario Mautino, Howard Streicher, Daniel M. Sullivan,  and Scott J. Antonia
22928-22938
Abstract  |  PDF  |  HTML  |  Order a Reprint

A scoring system based on artificial neural network for predicting 10-year survival in stage II A colon cancer patients after radical surgery

A scoring system based on artificial neural network for predicting 10-year survival in stage II A colon cancer patients after radical surgery

https://doi.org/10.18632/oncotarget.8217

Jian-Hong Peng, Yu-Jing Fang, Cai-Xia Li, Qing-Jian Ou, Wu Jiang, Shi-Xun Lu, Zhen-Hai Lu, Pei-Xing Li, Jing-Ping Yun, Rong-Xin Zhang, Zhi-Zhong Pan,  and De-Sen Wan
22939-22947
Abstract  |  PDF  |  HTML  |  Order a Reprint

Body mass index and cholesterol level predict surgical outcome in patients with hepatocellular carcinoma in Taiwan - a cohort study

Body mass index and cholesterol level predict surgical outcome in patients with hepatocellular carcinoma in Taiwan - a cohort study

https://doi.org/10.18632/oncotarget.8312

Ya-Ling Lee, Wan-Chun Li, Tung-Hu Tsai, Hsin-Yu Chiang,  and Chin-Tsung Ting
22948-22959
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Estimation of the risk of secondary malignancy arising from whole-breast irradiation: comparison of five radiotherapy modalities, including TomoHDA

Estimation of the risk of secondary malignancy arising from whole-breast irradiation: comparison of five radiotherapy modalities, including TomoHDA

https://doi.org/10.18632/oncotarget.8392

Eun Young Han, Nava Paudel, Jiwon Sung, Myonggeun Yoon, Weon Kuu Chung,  and Dong Wook Kim
22960-22969
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Corrections

Correction: Tudor staphylococcal nuclease drives chemoresistance of non-small cell lung carcinoma cells by regulating S100A11

Correction: Tudor staphylococcal nuclease drives chemoresistance of non-small cell lung carcinoma cells by regulating S100A11

https://doi.org/10.18632/oncotarget.8805

Anna Zagryazhskaya, Olga Surova, Nadeem S. Akbar, Giulia Allavena, Katarina Gyuraszova, Irina B. Zborovskaya, Elena M. Tchevkina,  and Boris Zhivotovsky
22970
Correction  |  PDF


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