Oncotarget

Vol 7, No 11

March 15, 2016

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Cis-acting elements in its 3′ UTR mediate post-transcriptional regulation of KRAS. See Kim et al.

Table of Contents

Editorial

L1 in tumor vasculature

L1 in tumor vasculature

https://doi.org/10.18632/oncotarget.7791

Ugo Cavallaro
11744-11745
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Research Perspectives

Drug resistance in cancer: molecular evolution and compensatory proliferation

Drug resistance in cancer: molecular evolution and compensatory proliferation

https://doi.org/10.18632/oncotarget.7459

Ran Friedman
11746-11755
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Priority Research Papers

Functional interactions of the cystine/glutamate antiporter, CD44v and MUC1-C oncoprotein in triple-negative breast cancer cells

Functional interactions of the cystine/glutamate antiporter, CD44v and MUC1-C oncoprotein in triple-negative breast cancer cells

https://doi.org/10.18632/oncotarget.7598

Masanori Hasegawa, Hidekazu Takahashi, Hasan Rajabi, Maroof Alam, Yozo Suzuki, Li Yin, Ashujit Tagde, Takahiro Maeda, Masayuki Hiraki, Vikas P. Sukhatme,  and Donald Kufe
11756-11769
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Cis-acting elements in its 3′ UTR mediate post-transcriptional regulation of KRAS

Cis-acting elements in its 3′ UTR mediate post-transcriptional regulation of KRAS

https://doi.org/10.18632/oncotarget.7599

Minlee Kim, Nicole Kogan,  and Frank J. Slack
11770-11784
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Video Interview with Dr. Frank Slack, ‪Harvard Medical School‬  |  Order a Reprint

p73 promotes glioblastoma cell invasion by directly activating POSTN (periostin) expression

p73 promotes glioblastoma cell invasion by directly activating POSTN (periostin) expression

https://doi.org/10.18632/oncotarget.7600

Vivien Landré, Alexey Antonov, Richard Knight,  and Gerry Melino
11785-11802
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Beneficial bacteria inhibit cachexia

Beneficial bacteria inhibit cachexia

https://doi.org/10.18632/oncotarget.7730

Bernard J. Varian, Sravya Goureshetti, Theofilos Poutahidis, Jessica R. Lakritz, Tatiana Levkovich, Caitlin Kwok, Konstantinos Teliousis, Yassin M. Ibrahim, Sheyla Mirabal,  and Susan E. Erdman
11803-11816
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Cancer therapeutic approach based on conformational stabilization of mutant p53 protein by small peptides

Cancer therapeutic approach based on conformational stabilization of mutant p53 protein by small peptides

https://doi.org/10.18632/oncotarget.7857

Perry Tal, Shay Eizenberger, Elad Cohen, Naomi Goldfinger, Shmuel Pietrokovski, Moshe Oren,  and Varda Rotter
11817-11837
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Loss of p53-mediated cell-cycle arrest, senescence and apoptosis promotes genomic instability and premature aging

Loss of p53-mediated cell-cycle arrest, senescence and apoptosis promotes genomic instability and premature aging

https://doi.org/10.18632/oncotarget.7864

Tongyuan Li, Xiangyu Liu, Le Jiang, James Manfredi, Shan Zha,  and Wei Gu
11838-11849
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Research Papers: Gerotarget (Focus on Aging)

The role of fine-needle aspiration in the thyroid nodules of elderly patients

The role of fine-needle aspiration in the thyroid nodules of elderly patients

https://doi.org/10.18632/oncotarget.7643

Esther Diana Rossi, Tommaso Bizzarro, Maurizio Martini, Patrizia Straccia, Celestino Pio Lombardi, Alfredo Pontecorvi, Luigi Maria Larocca,  and Guido Fadda
11850-11859
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In normal aging ventricular system never attains pathological values of Evans’ index

In normal aging ventricular system never attains pathological values of Evans’ index

https://doi.org/10.18632/oncotarget.7644

Paolo Missori, Aurelia Rughetti, Simone Peschillo, Gianfranco Gualdi, Claudio Di Biasi, Italo Nofroni, Lucio Marinelli, Francesco Fattapposta,  and Antonio Currà
11860-11863
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Severe chronic cerebral hypoperfusion induces microglial dysfunction leading to memory loss in APPswe/PS1 mice

Severe chronic cerebral hypoperfusion induces microglial dysfunction leading to memory loss in APPswe/PS1 mice

https://doi.org/10.18632/oncotarget.7689

Maude Bordeleau, Ayman ElAli,  and Serge Rivest
11864-11880
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The effect of D-serine administration on cognition and mood in older adults

The effect of D-serine administration on cognition and mood in older adults

https://doi.org/10.18632/oncotarget.7691

Marcos Avellar, Linda Scoriels, Caroline Madeira, Charles Vargas-Lopes, Priscila Marques, Camila Dantas, Alex C. Manhães, Homero Leite,  and Rogerio Panizzutti
11881-11888
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Loss of myocardial protection against myocardial infarction in middle-aged transgenic mice overexpressing cardiac thioredoxin-1

Loss of myocardial protection against myocardial infarction in middle-aged transgenic mice overexpressing cardiac thioredoxin-1

https://doi.org/10.18632/oncotarget.7726

Verónica D´Annunzio, Virginia Perez, Tamara Mazo, Marina C. Muñoz, Fernando P. Dominici, María C. Carreras, Juan José Poderoso, Junichi Sadoshima,  and Ricardo J. Gelpi
11889-11898
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Rationale and design of the allogeneiC human mesenchymal stem cells (hMSC) in patients with aging fRAilTy via intravenoUS delivery (CRATUS) study: A phase I/II, randomized, blinded and placebo controlled trial to evaluate the safety and potential efficacy of allogeneic human mesenchymal stem cell infusion in patients with aging frailty

Rationale and design of the allogeneiC human mesenchymal stem cells (hMSC) in patients with aging fRAilTy via intravenoUS delivery (CRATUS) study: A phase I/II, randomized, blinded and placebo controlled trial to evaluate the safety and potential efficacy of allogeneic human mesenchymal stem cell infusion in patients with aging frailty

https://doi.org/10.18632/oncotarget.7727

Samuel Golpanian, Darcy L. DiFede, Marietsy V. Pujol, Maureen H. Lowery, Silvina Levis-Dusseau, Bradley J. Goldstein, Ivonne H. Schulman, Bangon Longsomboon, Ariel Wolf, Aisha Khan, Alan W. Heldman, Pascal J. Goldschmidt-Clermont,  and Joshua M. Hare
11899-11912
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Age-related alterations in blood and colonic dendritic cell properties

Age-related alterations in blood and colonic dendritic cell properties

https://doi.org/10.18632/oncotarget.7799

Rakesh Vora, David Bernardo, Lydia Durant, Durga Reddi, Ailsa L. Hart, John M. E. Fell, Hafid O. Al-Hassi,  and Stella C. Knight
11913-11922
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Deletion of the γ-secretase subunits Aph1B/C impairs memory and worsens the deficits of knock-in mice modeling the Alzheimer-like familial Danish dementia

Deletion of the γ-secretase subunits Aph1B/C impairs memory and worsens the deficits of knock-in mice modeling the Alzheimer-like familial Danish dementia

https://doi.org/10.18632/oncotarget.7389

Fabrizio Biundo, Keita Ishiwari, Dolores Del Prete,  and Luciano D’Adamio
11923-11944
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Anti-TNF-α treatment modulates SASP and SASP-related microRNAs in endothelial cells and in circulating angiogenic cells

Anti-TNF-α treatment modulates SASP and SASP-related microRNAs in endothelial cells and in circulating angiogenic cells

https://doi.org/10.18632/oncotarget.7858

Francesco Prattichizzo, Angelica Giuliani, Rina Recchioni, Massimiliano Bonafè, Fiorella Marcheselli, Sabrina De Carolis, Anna Campanati, Katia Giuliodori, Maria Rita Rippo, Francesca Brugè, Luca Tiano, Carla Micucci, Antonio Ceriello, Annamaria Offidani, Antonio Domenico Procopio,  and Fabiola Olivieri
11945-11958
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Accelerated geroncogenesis in hereditary breast-ovarian cancer syndrome

Accelerated geroncogenesis in hereditary breast-ovarian cancer syndrome

https://doi.org/10.18632/oncotarget.7867

Javier A. Menendez, Núria Folguera-Blasco, Elisabet Cuyàs, Salvador Fernández-Arroyo, Jorge Joven,  and Tomás Alarcón
11959-11971
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Morphofunctional and signaling molecules overlap of the pineal gland and thymus: role and significance in aging

Morphofunctional and signaling molecules overlap of the pineal gland and thymus: role and significance in aging

https://doi.org/10.18632/oncotarget.7863

Michael A. Paltsev, Victoria O. Polyakova, Igor M. Kvetnoy, George Anderson, Tatiana V. Kvetnaia, Natalia S. Linkova, Ekaterina M. Paltseva, Rosa Rubino, Salvatore De Cosmo, Angelo De Cata,  and Gianluigi Mazzoccoli
11972-11983
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Research Papers: Pathology

CCR5 deficiency accelerates lipopolysaccharide-induced astrogliosis, amyloid-beta deposit and impaired memory function

CCR5 deficiency accelerates lipopolysaccharide-induced astrogliosis, amyloid-beta deposit and impaired memory function

https://doi.org/10.18632/oncotarget.7453

Chul Ju Hwang, Mi Hee Park, Jae Yeon Hwang, Ju Hwan Kim, Na Young Yun, Sang Yeon Oh, Ju Kyung Song, Hyun Ok Seo, Yun-Bae Kim, Dae Yeon Hwang, Ki-Wan Oh, Sang-Bae Han,  and Jin Tae Hong
11984-11999
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Ectopic mineralization of cartilage and collagen-rich tendons and ligaments in Enpp1asj-2J mice

Ectopic mineralization of cartilage and collagen-rich tendons and ligaments in Enpp1asj-2J mice

https://doi.org/10.18632/oncotarget.7455

Jieyu Zhang, Nathaniel A. Dyment, David W. Rowe, Sarah Y. Siu, John P. Sundberg, Jouni Uitto,  and Qiaoli Li
12000-12009
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CD226 reduces endothelial cell glucose uptake under hyperglycemic conditions with inflammation in type 2 diabetes mellitus

CD226 reduces endothelial cell glucose uptake under hyperglycemic conditions with inflammation in type 2 diabetes mellitus

https://doi.org/10.18632/oncotarget.7505

Yuan Zhang, Tian Liu, Yu Chen, Zilong Dong, Jinxue Zhang, Yizheng Sun, Boquan Jin, Feng Gao, Shuzhong Guo,  and Ran Zhuang
12010-12023
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

CD274/PD-L1 gene amplification and PD-L1 protein expression are common events in squamous cell carcinoma of the oral cavity

CD274/PD-L1 gene amplification and PD-L1 protein expression are common events in squamous cell carcinoma of the oral cavity

https://doi.org/10.18632/oncotarget.7593

Melanie Straub, Enken Drecoll, Nicole Pfarr, Wilko Weichert, Rupert Langer, Alexander Hapfelmeier, Carolin Götz, Klaus-Dietrich Wolff, Andreas Kolk,  and Katja Specht
12024-12034
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REST alleviates neurotoxic prion peptide-induced synaptic abnormalities, neurofibrillary degeneration and neuronal death partially via LRP6-mediated Wnt-β-catenin signaling

REST alleviates neurotoxic prion peptide-induced synaptic abnormalities, neurofibrillary degeneration and neuronal death partially via LRP6-mediated Wnt-β-catenin signaling

https://doi.org/10.18632/oncotarget.7640

Zhiqi Song, Ting Zhu, Xiangmei Zhou, Paul Barrow, Wei Yang, Yongyong Cui, Lifeng Yang,  and Deming Zhao
12035-12052
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Elevated expression of HIF-lα in actively growing prostate tissues is associated with clinical features of benign prostatic hyperplasia

Elevated expression of HIF-lα in actively growing prostate tissues is associated with clinical features of benign prostatic hyperplasia

https://doi.org/10.18632/oncotarget.7641

Fei Wu, Sentai Ding, Xin Li, Hui Wang, Shuai Liu, Haihu Wu, Dongbin Bi, Kejia Ding,  and Jiaju Lu
12053-12062
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GDF11/BMP11 activates both smad1/5/8 and smad2/3 signals but shows no significant effect on proliferation and migration of human umbilical vein endothelial cells

GDF11/BMP11 activates both smad1/5/8 and smad2/3 signals but shows no significant effect on proliferation and migration of human umbilical vein endothelial cells

https://doi.org/10.18632/oncotarget.7642

Yong-Hui Zhang, Feng Cheng, Xue-Ting Du, Jin-Lai Gao, Xiao-Lin Xiao, Na Li, Shan-Liang Li,  and De-Li Dong
12063-12074
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Melatonin protects skin keratinocyte from hydrogen peroxide-mediated cell death via the SIRT1 pathway

Melatonin protects skin keratinocyte from hydrogen peroxide-mediated cell death via the SIRT1 pathway

https://doi.org/10.18632/oncotarget.7679

Ju-Hee Lee, Ji-Hong Moon, Uddin MD. Nazim, You-Jin Lee, Jae-Won Seol, Seong-Kug Eo, John-Hwa Lee,  and Sang-Youel Park
12075-12088
Abstract  |  PDF  |  HTML  |  Order a Reprint

Low-dose tacrolimus combined with donor-derived mesenchymal stem cells after renal transplantation: a prospective, non-randomized study

Low-dose tacrolimus combined with donor-derived mesenchymal stem cells after renal transplantation: a prospective, non-randomized study

https://doi.org/10.18632/oncotarget.7725

Guang-hui Pan, Zheng Chen, Lu Xu, Jing-hui Zhu, Peng Xiang, Jun-jie Ma, Yan-wen Peng, Guang-hui Li, Xiao-yong Chen, Jia-li Fang, Yu-he Guo, Lei Zhang,  and Long-shan Liu
12089-12101
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Biological outcome and mapping of total factor cascades in response to HIF induction during regenerative angiogenesis

Biological outcome and mapping of total factor cascades in response to HIF induction during regenerative angiogenesis

https://doi.org/10.18632/oncotarget.7728

Abdel-Majid Khatib, Rachid Lahlil, Martin Hagedorn, Claudine Delomenie, Olivier Christophe, Cecile Denis,  and Geraldine Siegfried
12102-12120
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Decellularized allogeneic intervertebral disc: natural biomaterials for regenerating disc degeneration

Decellularized allogeneic intervertebral disc: natural biomaterials for regenerating disc degeneration

https://doi.org/10.18632/oncotarget.7735

Xianfeng Lin, Xiangqian Fang, Qiang Wang, Zhijun Hu, Kai Chen, Zhi Shan, Shuai Chen, Jiying Wang, Jian Mo, Jianjun Ma, Wenbing Xu, An Qin,  and Shunwu Fan
12121-12136
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Resveratrol suppresses myofibroblast activity of human buccal mucosal fibroblasts through the epigenetic inhibition of ZEB1 expression

Resveratrol suppresses myofibroblast activity of human buccal mucosal fibroblasts through the epigenetic inhibition of ZEB1 expression

https://doi.org/10.18632/oncotarget.7763

Yu-Chao Chang, Cheng-Wei Lin, Cheng-Chia Yu, Bing-Yen Wang, Yu-Hao Huang, Yang-Chih Hsieh, Yu-Liang Kuo,  and Wen-Wei Chang
12137-12149
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

PGC-1α overexpression protects against aldosterone-induced podocyte depletion: role of mitochondria

PGC-1α overexpression protects against aldosterone-induced podocyte depletion: role of mitochondria

https://doi.org/10.18632/oncotarget.7859

Min Zhao, Yanggang Yuan, Mi Bai, Guixia Ding, Zhanjun Jia, Songming Huang,  and Aihua Zhang
12150-12162
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Research Papers: Immunology

Human naïve regulatory T-cells feature high steady-state turnover and are maintained by IL-7

Human naïve regulatory T-cells feature high steady-state turnover and are maintained by IL-7

https://doi.org/10.18632/oncotarget.7512

Susana L. Silva, Adriana S. Albuquerque, Ana Serra-Caetano, Russell B. Foxall, Ana R. Pires, Paula Matoso, Susana M. Fernandes, João Ferreira, Rémi Cheynier, Rui M. M. Victorino, Iris Caramalho, João T. Barata,  and Ana E. Sousa
12163-12175
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A biodegradable killer microparticle to selectively deplete antigen-specific T cells in vitro and in vivo

A biodegradable killer microparticle to selectively deplete antigen-specific T cells in vitro and in vivo

https://doi.org/10.18632/oncotarget.7519

Wei Wang, Kun Fang, Miao-Chen Li, Di Chang, Khawar Ali Shahzad, Tao Xu, Lei Zhang, Ning Gu,  and Chuan-Lai Shen
12176-12190
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Cooperation of ETV6/RUNX1 and BCL2 enhances immunoglobulin production and accelerates glomerulonephritis in transgenic mice

Cooperation of ETV6/RUNX1 and BCL2 enhances immunoglobulin production and accelerates glomerulonephritis in transgenic mice

https://doi.org/10.18632/oncotarget.7687

Eva Bauer, Michaela Schlederer, Ruth Scheicher, Jaqueline Horvath, Petra Aigner, Ana-Iris Schiefer, Renate Kain, Heinz Regele, Gregor Hoermann, Günter Steiner, Lukas Kenner, Veronika Sexl, Andreas Villunger, Richard Moriggl,  and Dagmar Stoiber
12191-12205
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The epidermal growth factor receptor regulates cofilin activity and promotes transmissible gastroenteritis virus entry into intestinal epithelial cells

The epidermal growth factor receptor regulates cofilin activity and promotes transmissible gastroenteritis virus entry into intestinal epithelial cells

https://doi.org/10.18632/oncotarget.7723

Weiwei Hu, Liqi Zhu, Xing Yang, Jian Lin,  and Qian Yang
12206-12221
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The mitochondrial and death receptor pathways involved in the thymocytes apoptosis induced by aflatoxin B1

The mitochondrial and death receptor pathways involved in the thymocytes apoptosis induced by aflatoxin B1

https://doi.org/10.18632/oncotarget.7731

Xi Peng, Zhengqiang Yu, Na Liang, Xiaofeng Chi, Xiaochong Li, Min Jiang, Jing Fang, Hengmin Cui, Weimin Lai, Yi Zhou,  and Shan Zhou
12222-12234
Abstract  |  PDF  |  HTML  |  Order a Reprint

A bovine herpesvirus 1 pUL51 deletion mutant shows impaired viral growth in vitro and reduced virulence in rabbits

A bovine herpesvirus 1 pUL51 deletion mutant shows impaired viral growth in vitro and reduced virulence in rabbits

https://doi.org/10.18632/oncotarget.7771

Sohail Raza, Mingliang Deng, Farzana Shahin, Kui Yang, Changmin Hu, Yingyu Chen, Huanchun Chen,  and Aizhen Guo
12235-12253
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Research Papers: Autophagy and Cell Death

Endoplasmic reticulum stress-mediated induction of SESTRIN 2 potentiates cell survival

Endoplasmic reticulum stress-mediated induction of SESTRIN 2 potentiates cell survival

https://doi.org/10.18632/oncotarget.7601

Svetlana Saveljeva, Patricia Cleary, Katarzyna Mnich, Abiodun Ayo, Karolina Pakos-Zebrucka, John B. Patterson, Susan E. Logue,  and Afshin Samali
12254-12266
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Research Papers: Chromosome

Novel Mad2-targeting miR-493-3p controls mitotic fidelity and cancer cells’ sensitivity to paclitaxel

Novel Mad2-targeting miR-493-3p controls mitotic fidelity and cancer cells’ sensitivity to paclitaxel

https://doi.org/10.18632/oncotarget.7860

Mahesh Tambe, Sofia Pruikkonen, Jenni Mäki-Jouppila, Ping Chen, Bente Vilming Elgaaen, Anne Hege Straume, Kaisa Huhtinen, Olli Cárpen, Per Eystein Lønning, Ben Davidson, Sampsa Hautaniem,  and Marko J. Kallio
12267-12285
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Reviews: Autophagy and Cell Death

Autophagy: a decisive process for stemness

Autophagy: a decisive process for stemness

https://doi.org/10.18632/oncotarget.7766

Laura García-Prat, Marta Martínez-Vicente,  and Pura Muñoz-Cánoves
12286-12288
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Reviews

ALK and ROS1 as targeted therapy paradigms and clinical implications to overcome crizotinib resistance

ALK and ROS1 as targeted therapy paradigms and clinical implications to overcome crizotinib resistance

https://doi.org/10.18632/oncotarget.6935

Mingxiang Ye, Xinxin Zhang, Nan Li, Yong Zhang, Pengyu Jing, Ning Chang, Jianxiong Wu, Xinling Ren,  and Jian Zhang
12289-12304
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

CRISPR/Cas9 and cancer targets: future possibilities and present challenges

CRISPR/Cas9 and cancer targets: future possibilities and present challenges

https://doi.org/10.18632/oncotarget.7104

Martyn K. White,  and Kamel Khalili
12305-12317
Abstract  |  PDF  |  HTML  |  Order a Reprint

Stereotactic radiosurgery (SRS) in the modern management of patients with brain metastases

Stereotactic radiosurgery (SRS) in the modern management of patients with brain metastases

https://doi.org/10.18632/oncotarget.7131

Hany Soliman, Sunit Das, David A. Larson,  and Arjun Sahgal
12318-12330
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Research Papers

Nuclear localization of the caspase-3-cleaved form of p73 in anoikis

Nuclear localization of the caspase-3-cleaved form of p73 in anoikis

https://doi.org/10.18632/oncotarget.6329

Samar Alsafadi, Sophie Tourpin, Nadia Bessoltane, Sophie Salomé-Desnoulez, Gilles Vassal, Fabrice André,  and Jean-Charles Ahomadegbe
12331-12343
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A fully human CXCR4 antibody demonstrates diagnostic utility and therapeutic efficacy in solid tumor xenografts

A fully human CXCR4 antibody demonstrates diagnostic utility and therapeutic efficacy in solid tumor xenografts

https://doi.org/10.18632/oncotarget.7111

Babak Behnam Azad, Samit Chatterjee, Wojciech G. Lesniak, Ala Lisok, Mrudula Pullambhatla, Zaver M. Bhujwalla, Martin G. Pomper,  and Sridhar Nimmagadda
12344-12358
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Clonal relationships in recurrent B-cell lymphomas

Clonal relationships in recurrent B-cell lymphomas

https://doi.org/10.18632/oncotarget.7132

Seung Eun Lee, So Young Kang, Hae Yong Yoo, Seok Jin Kim, Won Seog Kim,  and Young Hyeh Ko
12359-12371
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SOX2 boosts major tumor progression genes in prostate cancer and is a functional biomarker of lymph node metastasis

SOX2 boosts major tumor progression genes in prostate cancer and is a functional biomarker of lymph node metastasis

https://doi.org/10.18632/oncotarget.6029

Marco Vincenzo Russo, Silvia Esposito, Maria Grazia Tupone, Lamberto Manzoli, Irma Airoldi, Paolo Pompa, Luca Cindolo, Luigi Schips, Carlo Sorrentino,  and Emma Di Carlo
12372-12385
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

NOTUM is a potential pharmacodynamic biomarker of Wnt pathway inhibition

NOTUM is a potential pharmacodynamic biomarker of Wnt pathway inhibition

https://doi.org/10.18632/oncotarget.7157

Babita Madan, Zhiyuan Ke, Zheng Deng Lei, Frois Ashley Oliver, Masanobu Oshima, May Ann Lee, Steve Rozen,  and David M. Virshup
12386-12392
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Angiomotin promotes renal epithelial and carcinoma cell proliferation by retaining the nuclear YAP

Angiomotin promotes renal epithelial and carcinoma cell proliferation by retaining the nuclear YAP

https://doi.org/10.18632/oncotarget.7161

Meng Lv, Shuting Li, Changqin Luo, Xiaoman Zhang, Yanwei Shen, YanXia Sui, Fan Wang, Xin Wang, Jiao Yang, Peijun Liu,  and Jin Yang
12393-12403
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The mechanism of acquired resistance to irreversible EGFR tyrosine kinase inhibitor-afatinib in lung adenocarcinoma patients

The mechanism of acquired resistance to irreversible EGFR tyrosine kinase inhibitor-afatinib in lung adenocarcinoma patients

https://doi.org/10.18632/oncotarget.7189

Shang-Gin Wu, Yi-Nan Liu, Meng-Feng Tsai, Yih-Leong Chang, Chong-Jen Yu, Pan-Chyr Yang, James Chih-Hsin Yang, Yueh-Feng Wen,  and Jin-Yuan Shih
12404-12413
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Circulating miR-21, miR-378, and miR-940 increase in response to an acute exhaustive exercise in chronic heart failure patients

Circulating miR-21, miR-378, and miR-940 increase in response to an acute exhaustive exercise in chronic heart failure patients

https://doi.org/10.18632/oncotarget.6966

Tianzhao Xu, Qiulian Zhou, Lin Che, Saumya Das, Lemin Wang, Jinfa Jiang, Guanghe Li, Jiahong Xu, Jianhua Yao, Hongbao Wang, Yue Dai,  and Junjie Xiao
12414-12425
Abstract  |  PDF  |  HTML  |  Order a Reprint

Addiction of lung cancer cells to GOF p53 is promoted by up-regulation of epidermal growth factor receptor through multiple contacts with p53 transactivation domain and promoter

Addiction of lung cancer cells to GOF p53 is promoted by up-regulation of epidermal growth factor receptor through multiple contacts with p53 transactivation domain and promoter

https://doi.org/10.18632/oncotarget.6998

Catherine A. Vaughan, Isabella Pearsall, Shilpa Singh, Brad Windle, Swati P. Deb, Steven R. Grossman, W. Andrew Yeudall,  and Sumitra Deb
12426-12446
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PP2A inhibition with LB100 enhances cisplatin cytotoxicity and overcomes cisplatin resistance in medulloblastoma cells

PP2A inhibition with LB100 enhances cisplatin cytotoxicity and overcomes cisplatin resistance in medulloblastoma cells

https://doi.org/10.18632/oncotarget.6970

Winson S. Ho, Michael J. Feldman, Dragan Maric, Lauren Amable, Matthew D. Hall, Gerald M. Feldman, Abhik Ray-Chaudhury, Martin J. Lizak, Juan-Carlos Vera, R. Aaron Robison, Zhengping Zhuang,  and John D. Heiss
12447-12463
Abstract  |  PDF  |  HTML  |  Order a Reprint

Inhibition of O-GlcNAc transferase activity reprograms prostate cancer cell metabolism

Inhibition of O-GlcNAc transferase activity reprograms prostate cancer cell metabolism

https://doi.org/10.18632/oncotarget.7039

Harri M. Itkonen, Saurabh S. Gorad, Damien Y. Duveau, Sarai E.S. Martin, Anna Barkovskaya, Tone F. Bathen, Siver A. Moestue,  and Ian G. Mills
12464-12476
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Therapeutic response and side effects of repeated radioligand therapy with 177Lu-PSMA-DKFZ-617 of castrate-resistant metastatic prostate cancer

Therapeutic response and side effects of repeated radioligand therapy with 177Lu-PSMA-DKFZ-617 of castrate-resistant metastatic prostate cancer

https://doi.org/10.18632/oncotarget.7245

Hojjat Ahmadzadehfar, Elisabeth Eppard, Stefan Kürpig, Rolf Fimmers, Anna Yordanova, Carl Diedrich Schlenkhoff, Florian Gärtner, Sebastian Rogenhofer,  and Markus Essler
12477-12488
Abstract  |  PDF  |  HTML  |  Order a Reprint

Intercellular transfer of small RNAs from astrocytes to lung tumor cells induces resistance to chemotherapy

Intercellular transfer of small RNAs from astrocytes to lung tumor cells induces resistance to chemotherapy

https://doi.org/10.18632/oncotarget.7273

Assaf Menachem, Victoria Makovski, Or Bodner, Metsada Pasmanik-Chor, Reuven Stein, Noam Shomron,  and Yoel Kloog
12489-12504
Abstract  |  PDF  |  HTML  |  Order a Reprint

Clinical and biological significance of HAX-1 overexpression in nasopharyngeal carcinoma

Clinical and biological significance of HAX-1 overexpression in nasopharyngeal carcinoma

https://doi.org/10.18632/oncotarget.7274

Bo You, Xiaolei Cao, Xiaoyi Shao, Haosheng Ni, Si Shi, Ying Shan, Zhifeng Gu,  and Yiwen You
12505-12524
Abstract  |  PDF  |  HTML  |  Order a Reprint

Naturally occurring basal core promoter A1762T/G1764A dual mutations increase the risk of HBV-related hepatocellular carcinoma: a meta-analysis

Naturally occurring basal core promoter A1762T/G1764A dual mutations increase the risk of HBV-related hepatocellular carcinoma: a meta-analysis

https://doi.org/10.18632/oncotarget.7123

Zongguo Yang, Liping Zhuang, Yunfei Lu, Qingnian Xu, Bozong Tang,  and Xiaorong Chen
12525-12536
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Rad18 is required for functional interactions between FANCD2, BRCA2, and Rad51 to repair DNA topoisomerase 1-poisons induced lesions and promote fork recovery

Rad18 is required for functional interactions between FANCD2, BRCA2, and Rad51 to repair DNA topoisomerase 1-poisons induced lesions and promote fork recovery

https://doi.org/10.18632/oncotarget.7247

Kaushlendra Tripathi, Chinnadurai Mani, David W Clark,  and Komaraiah Palle
12537-12553
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Mutant p53 protects ETS2 from non-canonical COP1/DET1 dependent degradation

Mutant p53 protects ETS2 from non-canonical COP1/DET1 dependent degradation

https://doi.org/10.18632/oncotarget.7275

Zunamys I. Carrero, Madhusudhan Kollareddy, Krishna M. Chauhan, Gopalakrishnan Ramakrishnan,  and Luis A. Martinez
12554-12567
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Inverse agonist of estrogen-related receptor α suppresses the growth of triple negative breast cancer cells through ROS generation and interaction with multiple cell signaling pathways

Inverse agonist of estrogen-related receptor α suppresses the growth of triple negative breast cancer cells through ROS generation and interaction with multiple cell signaling pathways

https://doi.org/10.18632/oncotarget.7276

Ying-Min Wu, Zhuo-Jia Chen, Guan-Min Jiang, Kun-Shui Zhang, Qiao Liu, Shu-Wei Liang, Yan Zhou, Hong-Bin Huang, Jun Du,  and Hong-Sheng Wang
12568-12581
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Phospholipid profiling identifies acyl chain elongation as a ubiquitous trait and potential target for the treatment of lung squamous cell carcinoma

Phospholipid profiling identifies acyl chain elongation as a ubiquitous trait and potential target for the treatment of lung squamous cell carcinoma

https://doi.org/10.18632/oncotarget.7179

Eyra Marien, Michael Meister, Thomas Muley, Teresa Gomez del Pulgar, Rita Derua, Jeffrey M. Spraggins, Raf Van de Plas, Frank Vanderhoydonc, Jelle Machiels, Maria Mercedes Binda, Jonas Dehairs, Jami Willette-Brown, Yinling Hu, Hendrik Dienemann, Michael Thomas, Philipp A. Schnabel, Richard M. Caprioli, Juan Carlos Lacal, Etienne Waelkens,  and Johannes V. Swinnen
12582-12597
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Characterization of long non-coding RNA-associated ceRNA network to reveal potential prognostic lncRNA biomarkers in human ovarian cancer

Characterization of long non-coding RNA-associated ceRNA network to reveal potential prognostic lncRNA biomarkers in human ovarian cancer

https://doi.org/10.18632/oncotarget.7181

Meng Zhou, Xiaojun Wang, Hongbo Shi, Liang Cheng, Zhenzhen Wang, Hengqiang Zhao, Lei Yang,  and Jie Sun
12598-12611
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Exploiting machine learning for predicting skeletal-related events in cancer patients with bone metastases

Exploiting machine learning for predicting skeletal-related events in cancer patients with bone metastases

https://doi.org/10.18632/oncotarget.7278

Zhiyu Wang, Xiaoting Wen, Yaohong Lu, Yang Yao,  and Hui Zhao
12612-12622
Abstract  |  PDF  |  HTML  |  Order a Reprint

Expression of the bitter receptor T2R38 in pancreatic cancer: localization in lipid droplets and activation by a bacteria-derived quorum-sensing molecule

Expression of the bitter receptor T2R38 in pancreatic cancer: localization in lipid droplets and activation by a bacteria-derived quorum-sensing molecule

https://doi.org/10.18632/oncotarget.7206

Matthias M. Gaida, Christine Mayer, Ulrike Dapunt, Sabine Stegmaier, Peter Schirmacher, Guido H. Wabnitz,  and G. Maria Hänsch
12623-12632
Abstract  |  PDF  |  HTML  |  Order a Reprint

Loss of MEN1 activates DNMT1 implicating DNA hypermethylation as a driver of MEN1 tumorigenesis

Loss of MEN1 activates DNMT1 implicating DNA hypermethylation as a driver of MEN1 tumorigenesis

https://doi.org/10.18632/oncotarget.7279

Ziqiang Yuan, Carmen Sánchez Claros, Masako Suzuki, Elaine C. Maggi, Justin D. Kaner, Noah Kinstlinger, Jolanta Gorecka, Thomas J. Quinn, Rula Geha, Amanda Corn, Jessica Pastoriza, Qiang Jing, Asha Adem, Hao Wu, Girum Alemu, Yi-Chieh Du, Deyou Zheng, John M. Greally,  and Steven K. Libutti
12633-12650
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Androgens downregulate miR-21 expression in breast cancer cells underlining the protective role of androgen receptor

Androgens downregulate miR-21 expression in breast cancer cells underlining the protective role of androgen receptor

https://doi.org/10.18632/oncotarget.7207

Ivan Casaburi, Grazia Maria Cesario, Ada Donà, Pietro Rizza, Saveria Aquila, Paola Avena, Marilena Lanzino, Michele Pellegrino, Adele Vivacqua, Paola Tucci, Catia Morelli, Sebastiano Andò,  and Diego Sisci
12651-12661
Abstract  |  PDF  |  HTML  |  Order a Reprint

Effectiveness of the Monte Carlo method in stereotactic radiation therapy applied to quasi-homogenous brain tumors

Effectiveness of the Monte Carlo method in stereotactic radiation therapy applied to quasi-homogenous brain tumors

https://doi.org/10.18632/oncotarget.7280

Ki Mun Kang, Bae Kwon Jeong, Hoon Sik Choi, Jin Ho Song, Byung-Do Park, Young Kyung Lim,  and Hojin Jeong
12662-12671
Abstract  |  PDF  |  HTML  |  Order a Reprint

miR-21 expression and clinical outcome in locally advanced pancreatic cancer: exploratory analysis of the pancreatic cancer Erbitux, radiotherapy and UFT (PERU) trial

miR-21 expression and clinical outcome in locally advanced pancreatic cancer: exploratory analysis of the pancreatic cancer Erbitux, radiotherapy and UFT (PERU) trial

https://doi.org/10.18632/oncotarget.7208

Khurum Khan, David Cunningham, Clare Peckitt, Sarah Barton, Diana Tait, Maria Hawkins, David Watkins, Naureen Starling, Sheela Rao, Ruwaida Begum, Janet Thomas, Jacqui Oates, Vincenza Guzzardo, Matteo Fassan, Chiara Braconi,  and Ian Chau
12672-12681
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Arsenic trioxide inhibits glioma cell growth through induction of telomerase displacement and telomere dysfunction

Arsenic trioxide inhibits glioma cell growth through induction of telomerase displacement and telomere dysfunction

https://doi.org/10.18632/oncotarget.7259

Ye Cheng, Yunqian Li, Chengyuan Ma, Yang Song, Haiyang Xu, Hongquan Yu, Songbai Xu, Qingchun Mu, Haisong Li, Yong Chen,  and Gang Zhao
12682-12692
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MALAT1 long ncRNA promotes gastric cancer metastasis by suppressing PCDH10

MALAT1 long ncRNA promotes gastric cancer metastasis by suppressing PCDH10

https://doi.org/10.18632/oncotarget.7281

Ying Qi, Hong Sain Ooi, Jun Wu, Jian Chen, Xiaoli Zhang, Sheng Tan, Qing Yu, Yuan-Yuan Li, Yani Kang, Hua Li, Zirui Xiong, Tao Zhu, Bingya Liu, Zhifeng Shao,  and Xiaodong Zhao
12693-12703
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The relationship between EZH2 expression and microRNA-31 in colorectal cancer and the role in evolution of the serrated pathway

The relationship between EZH2 expression and microRNA-31 in colorectal cancer and the role in evolution of the serrated pathway

https://doi.org/10.18632/oncotarget.7260

Hiroyoshi Kurihara, Reo Maruyama, Kazuya Ishiguro, Shinichi Kanno, Itaru Yamamoto, Keisuke Ishigami, Kei Mitsuhashi, Hisayoshi Igarashi, Miki Ito, Tokuma Tanuma, Yasutaka Sukawa, Kenji Okita, Tadashi Hasegawa, Kohzoh Imai, Hiroyuki Yamamoto, Yasuhisa Shinomura,  and Katsuhiko Nosho
12704-12717
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Regression/Eradication of gliomas in mice by a systemically-deliverable ATF5 dominant-negative peptide

Regression/Eradication of gliomas in mice by a systemically-deliverable ATF5 dominant-negative peptide

https://doi.org/10.18632/oncotarget.7212

Charles C. Cates, Angelo D. Arias, Lynn S. Nakayama Wong, Michael W. Lamé, Maxim Sidorov, Geraldine Cayanan, Douglas J. Rowland, Jennifer Fung, Georg Karpel-Massler, Markus D. Siegelin, Lloyd A. Greene,  and James M. Angelastro
12718-12730
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

miR-451a is underexpressed and targets AKT/mTOR pathway in papillary thyroid carcinoma

miR-451a is underexpressed and targets AKT/mTOR pathway in papillary thyroid carcinoma

https://doi.org/10.18632/oncotarget.7262

Emanuela Minna, Paola Romeo, Matteo Dugo, Loris De Cecco, Katia Todoerti, Silvana Pilotti, Federica Perrone, Ettore Seregni, Luca Agnelli, Antonino Neri, Angela Greco,  and Maria Grazia Borrello
12731-12747
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Classification of large circulating tumor cells isolated with ultra-high throughput microfluidic Vortex technology

Classification of large circulating tumor cells isolated with ultra-high throughput microfluidic Vortex technology

https://doi.org/10.18632/oncotarget.7220

James Che, Victor Yu, Manjima Dhar, Corinne Renier, Melissa Matsumoto, Kyra Heirich, Edward B. Garon, Jonathan Goldman, Jianyu Rao, George W. Sledge, Mark D. Pegram, Shruti Sheth, Stefanie S. Jeffrey, Rajan P. Kulkarni, Elodie Sollier,  and Dino Di Carlo
12748-12760
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

High Mobility Group A2 protects cancer cells against telomere dysfunction

High Mobility Group A2 protects cancer cells against telomere dysfunction

https://doi.org/10.18632/oncotarget.6938

Suchitra Natarajan, Farhana Begum, Jeonga Gim, Landon Wark, Dana Henderson, James R. Davie, Sabine Hombach-Klonisch,  and Thomas Klonisch
12761-12782
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Tumor-targeting Salmonella typhimurium A1-R in combination with doxorubicin eradicate soft tissue sarcoma in a patient-derived orthotopic xenograft (PDOX) model

Tumor-targeting Salmonella typhimurium A1-R in combination with doxorubicin eradicate soft tissue sarcoma in a patient-derived orthotopic xenograft (PDOX) model

https://doi.org/10.18632/oncotarget.7226

Takashi Murakami, Jonathan DeLong, Fritz C. Eilber, Ming Zhao, Yong Zhang, Nan Zhang, Arun Singh, Tara Russell, Samantha Deng, Jose Reynoso, Cuong Quan, Yukihiko Hiroshima, Ryusei Matsuyama, Takashi Chishima, Kuniya Tanaka, Michael Bouvet, Sant Chawla, Itaru Endo,  and Robert M. Hoffman
12783-12790
Abstract  |  PDF  |  HTML  |  Order a Reprint

Inhibition of deubiquitinases primes glioblastoma cells to apoptosis in vitro and in vivo

Inhibition of deubiquitinases primes glioblastoma cells to apoptosis in vitro and in vivo

https://doi.org/10.18632/oncotarget.7302

Georg Karpel-Massler, Matei A. Banu, Chang Shu, Marc-Eric Halatsch, Mike-Andrew Westhoff, Jeffrey N. Bruce, Peter Canoll,  and Markus D. Siegelin
12791-12805
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Association of rituximab with graphene oxide confers direct cytotoxicity for CD20-positive lymphoma cells

Association of rituximab with graphene oxide confers direct cytotoxicity for CD20-positive lymphoma cells

https://doi.org/10.18632/oncotarget.7230

Chengke Luo, Zhenghao Deng, Lan Li, Frederic Clayton, Alexander L. Chen, Ran Wei, Rodney Miles, Deborah M. Stephens, Martha Glenn, Xiyang Wang, Peter E. Jensen,  and Xinjian Chen
12806-12822
Abstract  |  PDF  |  HTML  |  Order a Reprint

G protein-coupled receptor GPR160 is associated with apoptosis and cell cycle arrest of prostate cancer cells

G protein-coupled receptor GPR160 is associated with apoptosis and cell cycle arrest of prostate cancer cells

https://doi.org/10.18632/oncotarget.7313

Caihong Zhou, Xinchuan Dai, Yi Chen, Yanyan Shen, Saifei Lei, Ting Xiao, Tamas Bartfai, Jian Ding,  and Ming-Wei Wang
12823-12839
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Induction of cancer testis antigen expression in circulating acute myeloid leukemia blasts following hypomethylating agent monotherapy

Induction of cancer testis antigen expression in circulating acute myeloid leukemia blasts following hypomethylating agent monotherapy

https://doi.org/10.18632/oncotarget.7326

Pragya Srivastava, Benjamin E. Paluch, Junko Matsuzaki, Smitha R. James, Golda Collamat-Lai, Nadja Blagitko-Dorfs, Laurie Ann Ford, Rafeh Naqash, Michael Lübbert, Adam R. Karpf, Michael J. Nemeth,  and Elizabeth A. Griffiths
12840-12856
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Honokiol bis-dichloroacetate (Honokiol DCA) demonstrates activity in vemurafenib-resistant melanoma in vivo

Honokiol bis-dichloroacetate (Honokiol DCA) demonstrates activity in vemurafenib-resistant melanoma in vivo

https://doi.org/10.18632/oncotarget.7289

Michael Y. Bonner, Isabella Karlsson, Monica Rodolfo, Rebecca S. Arnold, Elisabetta Vergani,  and Jack L. Arbiser
12857-12868
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

SREBP-2 promotes stem cell-like properties and metastasis by transcriptional activation of c-Myc in prostate cancer

SREBP-2 promotes stem cell-like properties and metastasis by transcriptional activation of c-Myc in prostate cancer

https://doi.org/10.18632/oncotarget.7331

Xiangyan Li, Jason Boyang Wu, Qinlong Li, Katsumi Shigemura, Leland W.K. Chung,  and Wen-Chin Huang
12869-12884
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Decision aid on breast cancer screening reduces attendance rate: results of a large-scale, randomized, controlled study by the DECIDEO group

Decision aid on breast cancer screening reduces attendance rate: results of a large-scale, randomized, controlled study by the DECIDEO group

https://doi.org/10.18632/oncotarget.7332

Aurelie Bourmaud, Patricia Soler-Michel, Mathieu Oriol, Véronique Regnier, Fabien Tinquaut, Alice Nourissat, Alain Bremond, Nora Moumjid,  and Franck Chauvin
12885-12892
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MLN-8237: A dual inhibitor of aurora A and B in soft tissue sarcomas

MLN-8237: A dual inhibitor of aurora A and B in soft tissue sarcomas

https://doi.org/10.18632/oncotarget.7335

Jayasree S. Nair,  and Gary K. Schwartz
12893-12903
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Serum metabolomic profiling facilitates the non-invasive identification of metabolic biomarkers associated with the onset and progression of non-small cell lung cancer

Serum metabolomic profiling facilitates the non-invasive identification of metabolic biomarkers associated with the onset and progression of non-small cell lung cancer

https://doi.org/10.18632/oncotarget.7354

Leonor Puchades-Carrasco, Eloisa Jantus-Lewintre, Clara Pérez-Rambla, Francisco García-García, Rut Lucas, Silvia Calabuig, Ana Blasco, Joaquín Dopazo, Carlos Camps,  and Antonio Pineda-Lucena
12904-12916
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A novel small molecule STAT3 inhibitor, LY5, inhibits cell viability, colony formation, and migration of colon and liver cancer cells

A novel small molecule STAT3 inhibitor, LY5, inhibits cell viability, colony formation, and migration of colon and liver cancer cells

https://doi.org/10.18632/oncotarget.7338

Chongqiang Zhao, Wenlong Wang, Wenying Yu, David Jou, Yina Wang, Haiyan Ma, Hui Xiao, Hua Qin, Cuntai Zhang, Jiagao Lü, Sheng Li, Chenglong Li, Jiayuh Lin,  and Li Lin
12917-12926
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Targeting DNA repair by coDbait enhances melanoma targeted radionuclide therapy

Targeting DNA repair by coDbait enhances melanoma targeted radionuclide therapy

https://doi.org/10.18632/oncotarget.7340

Claire Viallard, Jean-Michel Chezal, Florence Mishellany, Isabelle Ranchon-Cole, Bruno Pereira, Aurélie Herbette, Sophie Besse, Zied Boudhraa, Nathalie Jacquemot, Anne Cayre, Elisabeth Miot-Noirault, Jian-Sheng Sun, Marie Dutreix,  and Françoise Degoul
12927-12936
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MicroRNA-138 promotes acquired alkylator resistance in glioblastoma by targeting the Bcl-2-interacting mediator BIM

MicroRNA-138 promotes acquired alkylator resistance in glioblastoma by targeting the Bcl-2-interacting mediator BIM

https://doi.org/10.18632/oncotarget.7346

Nina Stojcheva, Gennadi Schechtmann, Steffen Sass, Patrick Roth, Ana-Maria Florea, Anja Stefanski, Kai Stühler, Marietta Wolter, Nikola S. Müller, Fabian J. Theis, Michael Weller, Guido Reifenberger,  and Caroline Happold
12937-12950
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Targeting the p53-MDM2 interaction by the small-molecule MDM2 antagonist Nutlin-3a: a new challenged target therapy in adult Philadelphia positive acute lymphoblastic leukemia patients

Targeting the p53-MDM2 interaction by the small-molecule MDM2 antagonist Nutlin-3a: a new challenged target therapy in adult Philadelphia positive acute lymphoblastic leukemia patients

https://doi.org/10.18632/oncotarget.7339

Stefania Trino, Ilaria Iacobucci, Daniela Erriquez, Ilaria Laurenzana, Luciana De Luca, Anna Ferrari, Andrea Ghelli Luserna Di Rorà, Cristina Papayannidis, Enrico Derenzini, Giorgia Simonetti, Annalisa Lonetti, Claudia Venturi, Federica Cattina, Emanuela Ottaviani, Maria Chiara Abbenante, Domenico Russo, Giovanni Perini, Pellegrino Musto,  and Giovanni Martinelli
12951-12961
Abstract  |  PDF  |  HTML  |  Order a Reprint

Rapid generation of novel models of RAG1 deficiency by CRISPR/Cas9-induced mutagenesis in murine zygotes

Rapid generation of novel models of RAG1 deficiency by CRISPR/Cas9-induced mutagenesis in murine zygotes

https://doi.org/10.18632/oncotarget.7341

Lisa Ott de Bruin, Wei Yang, Kelly Capuder, Yu Nee Lee, Maddalena Antolini, Robin Meyers, Martin Gellert, Kiran Musunuru, John Manis,  and Luigi Notarangelo
12962-12974
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Multi-kinase inhibitors can associate with heat shock proteins through their NH2-termini by which they suppress chaperone function

Multi-kinase inhibitors can associate with heat shock proteins through their NH2-termini by which they suppress chaperone function

https://doi.org/10.18632/oncotarget.7349

Laurence Booth, Brian Shuch, Thomas Albers, Jane L. Roberts, Mehrad Tavallai, Stefan Proniuk, Alexander Zukiwski, Dasheng Wang, Ching-Shih Chen, Don Bottaro, Heath Ecroyd, Iryna O. Lebedyeva,  and Paul Dent
12975-12996
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Osteopontin promotes epithelial-mesenchymal transition of hepatocellular carcinoma through regulating vimentin

Osteopontin promotes epithelial-mesenchymal transition of hepatocellular carcinoma through regulating vimentin

https://doi.org/10.18632/oncotarget.7016

Qiongzhu Dong, Xuchao Zhu, Chun Dai, Xiaofei Zhang, Xiaomei Gao, Jinwang Wei, Yuanyuan Sheng, Yan Zheng, Jian Yu, Lu Xie, Yi Qin, Peng Qiao, Chuang Zhou, Xinxin Yu, Huliang Jia, Ning Ren, Haijun Zhou, Qinghai Ye,  and Lunxiu Qin
12997-13012
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Prognostic relevance of HER2/neu in acute lymphoblastic leukemia and induction of NK cell reactivity against primary ALL blasts by trastuzumab

Prognostic relevance of HER2/neu in acute lymphoblastic leukemia and induction of NK cell reactivity against primary ALL blasts by trastuzumab

https://doi.org/10.18632/oncotarget.7344

Sebastian P. Haen, Benjamin J. Schmiedel, Kathrin Rothfelder, Bastian J. Schmied, Truong-Minh Dang, Nora Mirza, Robert Möhle, Lothar Kanz, Wichard Vogel,  and Helmut R. Salih
13013-13030
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Expression of S1P metabolizing enzymes and receptors correlate with survival time and regulate cell migration in glioblastoma multiforme

Expression of S1P metabolizing enzymes and receptors correlate with survival time and regulate cell migration in glioblastoma multiforme

https://doi.org/10.18632/oncotarget.7366

Sandra Bien-Möller, Sandra Lange, Tobias Holm, Andreas Böhm, Heiko Paland, Johannes Küpper, Susann Herzog, Kerstin Weitmann, Christoph Havemann, Silke Vogelgesang, Sascha Marx, Wolfgang Hoffmann, Henry W.S. Schroeder,  and Bernhard H. Rauch
13031-13046
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

LncRNAs as new biomarkers to differentiate triple negative breast cancer from non-triple negative breast cancer

LncRNAs as new biomarkers to differentiate triple negative breast cancer from non-triple negative breast cancer

https://doi.org/10.18632/oncotarget.7509

Mingming Lv, Pengfei Xu, Ying Wu, Lei Huang, Wenqu Li, Shanshan Lv, Xiaowei Wu, Xin Zeng, Rong Shen, Xuemei Jia, Yongmei Yin, Yun Gu, Hongyan Yuan, Hui Xie,  and Ziyi Fu
13047-13059
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Tumor CTLA-4 overexpression predicts poor survival in patients with nasopharyngeal carcinoma

Tumor CTLA-4 overexpression predicts poor survival in patients with nasopharyngeal carcinoma

https://doi.org/10.18632/oncotarget.7421

Pei-Yu Huang, Shan-Shan Guo, Yu Zhang, Jia-Bin Lu, Qiu-Yan Chen, Lin-Quan Tang, Lu Zhang, Li-Ting Liu, Li Zhang,  and Hai-Qiang Mai
13060-13068
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Validation of a preclinical model for assessment of drug efficacy in melanoma

Validation of a preclinical model for assessment of drug efficacy in melanoma

https://doi.org/10.18632/oncotarget.7541

Julie Delyon, Mariana Varna, Jean-Paul Feugeas, Aurélie Sadoux, Saliha Yahiaoui, Marie-Pierre Podgorniak, Geoffroy Leclert, Sarra Mazouz Dorval, Nicolas Dumaz, Anne Janin, Samia Mourah,  and Céleste Lebbé
13069-13081
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Development of 89Zr-Ontuxizumab for in vivo TEM-1/endosialin PET applications

Development of 89Zr-Ontuxizumab for in vivo TEM-1/endosialin PET applications

https://doi.org/10.18632/oncotarget.7552

Sara E.S. Lange, Alex Zheleznyak, Matthew Studer, Daniel J. O’Shannessy, Suzanne E. Lapi,  and Brian A. Van Tine
13082-13092
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The human 2B4 and NTB-A receptors bind the influenza viral hemagglutinin and co-stimulate NK cell cytotoxicity

The human 2B4 and NTB-A receptors bind the influenza viral hemagglutinin and co-stimulate NK cell cytotoxicity

https://doi.org/10.18632/oncotarget.7597

Alexandra Duev-Cohen, Yotam Bar-On, Ariella Glasner, Orit Berhani, Yael Ophir, Francesca Levi-Schaffer, Michal Mandelboim,  and Ofer Mandelboim
13093-13105
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The SOX11 transcription factor is a critical regulator of basal-like breast cancer growth, invasion, and basal-like gene expression

The SOX11 transcription factor is a critical regulator of basal-like breast cancer growth, invasion, and basal-like gene expression

https://doi.org/10.18632/oncotarget.7437

Jonathan H. Shepherd, Ivan P. Uray, Abhijit Mazumdar, Anna Tsimelzon, Michelle Savage, Susan G. Hilsenbeck,  and Powel H. Brown
13106-13121
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AEG-1/MTDH-activated autophagy enhances human malignant glioma susceptibility to TGF-β1-triggered epithelial-mesenchymal transition

AEG-1/MTDH-activated autophagy enhances human malignant glioma susceptibility to TGF-β1-triggered epithelial-mesenchymal transition

https://doi.org/10.18632/oncotarget.7536

Meijuan Zou, Wei Zhu, Li Wang, Lei Shi, Rui Gao, Yingwei Ou, Xuguan Chen, Zhongchang Wang, Aiqin Jiang, Kunmei Liu, Ming Xiao, Ping Ni, Dandan Wu, Wenping He, Geng Sun, Ping Li, Sulan Zhai, Xuerong Wang,  and Gang Hu
13122-13138
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

miR-194 inhibits the proliferation, invasion, migration, and enhances the chemosensitivity of non-small cell lung cancer cells by targeting forkhead box A1 protein

miR-194 inhibits the proliferation, invasion, migration, and enhances the chemosensitivity of non-small cell lung cancer cells by targeting forkhead box A1 protein

https://doi.org/10.18632/oncotarget.7545

Xuchao Zhu, Dan Li, Fei Yu, Chengyou Jia, Jing Xie, Yushui Ma, Suyun Fan, Haidong Cai, Qiong Luo, Zhongwei Lv,  and Lihong Fan
13139-13152
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Effective use of PI3K inhibitor BKM120 and PARP inhibitor Olaparib to treat PIK3CA mutant ovarian cancer

Effective use of PI3K inhibitor BKM120 and PARP inhibitor Olaparib to treat PIK3CA mutant ovarian cancer

https://doi.org/10.18632/oncotarget.7549

Dong Wang, Min Wang, Nan Jiang, Yuan Zhang, Xing Bian, Xiaoqing Wang, Thomas M. Roberts, Jean J. Zhao, Pixu Liu,  and Hailing Cheng
13153-13166
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Absent and abundant MET immunoreactivity is associated with poor prognosis of patients with oral and oropharyngeal squamous cell carcinoma

Absent and abundant MET immunoreactivity is associated with poor prognosis of patients with oral and oropharyngeal squamous cell carcinoma

https://doi.org/10.18632/oncotarget.7534

Maria J. De Herdt, Stefan M. Willems, Berdine van der Steen, Rob Noorlag, Esther I. Verhoef, Geert J.L.H. van Leenders, Robert J.J. van Es, Senada Koljenović, Robert J. Baatenburg de Jong,  and Leendert H.J. Looijenga
13167-13181
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Ursolic acid inhibits the growth of human pancreatic cancer and enhances the antitumor potential of gemcitabine in an orthotopic mouse model through suppression of the inflammatory microenvironment

Ursolic acid inhibits the growth of human pancreatic cancer and enhances the antitumor potential of gemcitabine in an orthotopic mouse model through suppression of the inflammatory microenvironment

https://doi.org/10.18632/oncotarget.7537

Sahdeo Prasad, Vivek R. Yadav, Bokyung Sung, Subash C. Gupta, Amit K. Tyagi,  and Bharat B. Aggarwal
13182-13196
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PARP activation promotes nuclear AID accumulation in lymphoma cells

PARP activation promotes nuclear AID accumulation in lymphoma cells

https://doi.org/10.18632/oncotarget.7603

Sandra Tepper, Julia Jeschke, Katrin Böttcher, Angelika Schmidt, Kathrin Davari, Peter Müller, Elisabeth Kremmer, Peter Hemmerich, Ines Pfeil,  and Berit Jungnickel
13197-13208
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Clinical Research Papers

Neoadjuvant chemotherapy and trastuzumab versus neoadjuvant chemotherapy followed by post-operative trastuzumab for patients with HER2-positive breast cancer

Neoadjuvant chemotherapy and trastuzumab versus neoadjuvant chemotherapy followed by post-operative trastuzumab for patients with HER2-positive breast cancer

https://doi.org/10.18632/oncotarget.4801

Carlo Palmieri, Iain RJ Macpherson, Kelvin Yan, Felipe Ades, Pippa Riddle, Riz Ahmed, Waheeda Owadally, Barbara Stanley, Deep Shah, Ondrej Gojis, Adam Januszewski, Conrad Lewanski, Rebecca Asher, Daniel Lythgoe, Evandro de Azambuja, Mark Beresford,  and Sacha J. Howell
13209-13220
Abstract  |  PDF  |  HTML  |  Order a Reprint

Efficacy and toxicity of bevacizumab in recurrent ovarian disease: an update meta-analysis on phase III trials

Efficacy and toxicity of bevacizumab in recurrent ovarian disease: an update meta-analysis on phase III trials

https://doi.org/10.18632/oncotarget.6507

Claudia Marchetti, Francesca De Felice, Innocenza Palaia, Angela Musella, Violante Di Donato, Maria Luisa Gasparri, Daniela Musio, Ludovico Muzii, Vincenzo Tombolini,  and Pierluigi Benedetti Panici
13221-13227
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Marital status independently predicts gastric cancer survival after surgical resection--an analysis of the SEER database

Marital status independently predicts gastric cancer survival after surgical resection--an analysis of the SEER database

https://doi.org/10.18632/oncotarget.7107

Rong-liang Shi, Qian Chen, Zhen Yang, Gaofeng Pan, Ziping Zhang, WeiHua Wang, Shaoqun Liu, Dongbin Zhang, Daowen Jiang,  and Weiyan Liu
13228-13235
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Ioncopy: a novel method for calling copy number alterations in amplicon sequencing data including significance assessment

Ioncopy: a novel method for calling copy number alterations in amplicon sequencing data including significance assessment

https://doi.org/10.18632/oncotarget.7451

Jan Budczies, Nicole Pfarr, Albrecht Stenzinger, Denise Treue, Volker Endris, Fakher Ismaeel, Nikola Bangemann, Jens-Uwe Blohmer, Manfred Dietel, Sibylle Loibl, Frederick Klauschen, Wilko Weichert,  and Carsten Denkert
13236-13247
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Computed tomography texture analysis to facilitate therapeutic decision making in hepatocellular carcinoma

Computed tomography texture analysis to facilitate therapeutic decision making in hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.7467

Meng Li, Sirui Fu, Yanjie Zhu, Zaiyi Liu, Shuting Chen, Ligong Lu,  and Changhong Liang
13248-13259
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Case Reports

Targeting the PD-1 pathway in patients with relapsed classic Hodgkin lymphoma following allogeneic stem cell transplant is safe and effective

Targeting the PD-1 pathway in patients with relapsed classic Hodgkin lymphoma following allogeneic stem cell transplant is safe and effective

https://doi.org/10.18632/oncotarget.7177

Jose Caetano Villasboas, Stephen M. Ansell,  and Thomas E. Witzig
13260-13264
Abstract  |  PDF  |  HTML  |  Order a Reprint

Acquired-resistance of bevacizumab treatment for radiation brain necrosis: a case report

Acquired-resistance of bevacizumab treatment for radiation brain necrosis: a case report

https://doi.org/10.18632/oncotarget.7724

Hongqing Zhuang, Xiangkun Yuan, Dayong Sun, Jianliang Bian, Joe Y. Chang, Zhiyong Yuan,  and Ping Wang
13265-13268
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