Oncotarget

Vol 7, No 10

March 8, 2016

View Archive »

Order a Reprint

About The Cover

Brachyury identifies a class of enteroendocrine cells in normal human intestinal crypts and colorectal cancer. See Jezkova et al.

Table of Contents

Editorial: Immunology

CXCL10 and blood-brain barrier modulation in rabies virus infection

CXCL10 and blood-brain barrier modulation in rabies virus infection

https://doi.org/10.18632/oncotarget.7428

Clement W. Gnanadurai,  and Zhen F. Fu
10694-10695
PDF  |  Order a Reprint

Priority Research Papers

A synthetic-lethality RNAi screen reveals an ERK-mTOR co-targeting pro-apoptotic switch in PIK3CA+ oral cancers

A synthetic-lethality RNAi screen reveals an ERK-mTOR co-targeting pro-apoptotic switch in PIK3CA+ oral cancers

https://doi.org/10.18632/oncotarget.7372

Kosuke Yamaguchi, Ramiro Iglesias-Bartolomé, Zhiyong Wang, Juan Luis Callejas-Valera, Panomwat Amornphimoltham, Alfredo A. Molinolo, Ezra E. Cohen, Joseph A. Califano, Scott M. Lippman, Ji Luo,  and J. Silvio Gutkind
10696-10709
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Aryl hydrocarbon receptor nuclear translocator (ARNT) isoforms control lymphoid cancer cell proliferation through differentially regulating tumor suppressor p53 activity

Aryl hydrocarbon receptor nuclear translocator (ARNT) isoforms control lymphoid cancer cell proliferation through differentially regulating tumor suppressor p53 activity

https://doi.org/10.18632/oncotarget.7539

Kacie A. Gardella, Israel Muro, Gloria Fang, Krishnakali Sarkar, Omayra Mendez,  and Casey W. Wright
10710-10722
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MicroRNA dysregulation and esophageal cancer development depend on the extent of zinc dietary deficiency

MicroRNA dysregulation and esophageal cancer development depend on the extent of zinc dietary deficiency

https://doi.org/10.18632/oncotarget.7561

Louise Y. Fong, Cristian Taccioli, Ruiyan Jing, Karl J. Smalley, Hansjuerg Alder, Yubao Jiang, Paolo Fadda, John L. Farber,  and Carlo M. Croce
10723-10738
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MPL W515L expression induces TGFβ secretion and leads to an increase in chemokinesis via phosphorylation of THOC5

MPL W515L expression induces TGFβ secretion and leads to an increase in chemokinesis via phosphorylation of THOC5

https://doi.org/10.18632/oncotarget.7639

Anthony D. Whetton, Norhaida Che Azmi, Stella Pearson, Ewa Jaworska, Liqun Zhang, Rognvald Blance, Alexandra C. Kendall, Anna Nicolaou, Samuel Taylor, Andrew J.K. Williamson,  and Andrew Pierce
10739-10755
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Research Papers: Gerotarget (Focus on Aging)

NFE2L2 variations reduce antioxidant response in patients with Parkinson disease

NFE2L2 variations reduce antioxidant response in patients with Parkinson disease

https://doi.org/10.18632/oncotarget.7353

YaXing Gui, LiShan Zhang, Wen Lv, WenMing Zhang, JinJia Zhao,  and XingYue Hu
10756-10764
Abstract  |  PDF  |  HTML  |  Order a Reprint

DNA methylation in PRDM8 is indicative for dyskeratosis congenita

DNA methylation in PRDM8 is indicative for dyskeratosis congenita

https://doi.org/10.18632/oncotarget.7458

Carola I. Weidner, Qiong Lin, Carina Birkhofer, Uwe Gerstenmaier, Andrea Kaifie, Martin Kirschner, Heiko Bruns, Stefan Balabanov, Arne Trummer, Clemens Stockklausner, Britta Höchsmann, Hubert Schrezenmeier, Marcin Wlodarski, Jens Panse, Tim H. Brümmendorf, Fabian Beier,  and Wolfgang Wagner
10765-10772
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Metformin regulates oxLDL-facilitated endothelial dysfunction by modulation of SIRT1 through repressing LOX-1-modulated oxidative signaling

Metformin regulates oxLDL-facilitated endothelial dysfunction by modulation of SIRT1 through repressing LOX-1-modulated oxidative signaling

https://doi.org/10.18632/oncotarget.7387

Ching-Hsia Hung, Shih-Hung Chan, Pei-Ming Chu, Huei-Chen Lin,  and Kun-Ling Tsai
10773-10787
Abstract  |  PDF  |  HTML  |  Order a Reprint

Identity, proliferation capacity, genomic stability and novel senescence markers of mesenchymal stem cells isolated from low volume of human bone marrow

Identity, proliferation capacity, genomic stability and novel senescence markers of mesenchymal stem cells isolated from low volume of human bone marrow

https://doi.org/10.18632/oncotarget.7456

Gabrielis Kundrotas, Evelina Gasperskaja, Grazina Slapsyte, Zivile Gudleviciene, Jan Krasko, Ausra Stumbryte,  and Regina Liudkeviciene
10788-10802
Abstract  |  PDF  |  HTML  |  Order a Reprint

Identification of long non-coding RNAs as novel biomarker and potential therapeutic target for atrial fibrillation in old adults

Identification of long non-coding RNAs as novel biomarker and potential therapeutic target for atrial fibrillation in old adults

https://doi.org/10.18632/oncotarget.7514

Yingjia Xu, Ritai Huang, Jianing Gu,  and Weifeng Jiang
10803-10811
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Stress resistance and lifespan are increased in C. elegans but decreased in S. cerevisiae by mafr-1/maf1 deletion

Stress resistance and lifespan are increased in C. elegans but decreased in S. cerevisiae by mafr-1/maf1 deletion

https://doi.org/10.18632/oncotarget.7769

Ying Cai,  and Yue-Hua Wei
10812-10826
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Research Papers: Pathology

Construction and analysis of cardiac hypertrophy-associated lncRNA-mRNA network based on competitive endogenous RNA reveal functional lncRNAs in cardiac hypertrophy

Construction and analysis of cardiac hypertrophy-associated lncRNA-mRNA network based on competitive endogenous RNA reveal functional lncRNAs in cardiac hypertrophy

https://doi.org/10.18632/oncotarget.7312

Chao Song, Jian Zhang, Yan Liu, Hao Pan, Han-ping Qi, Yong-gang Cao, Jian-mei Zhao, Shang Li, Jing Guo, Hong-li Sun,  and Chun-quan Li
10827-10840
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Targeting c-fms kinase attenuates chronic aristolochic acid nephropathy in mice

Targeting c-fms kinase attenuates chronic aristolochic acid nephropathy in mice

https://doi.org/10.18632/oncotarget.7460

Xiao Y. Dai, Xiao R. Huang, Xiao R. Huang, Li Zhou, Lin Zhang, Ping Fu, Carl Manthey, David J. Nikolic-Paterson,  and Hui Y. Lan
10841-10856
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

An efficient model of human endometriosis by induced unopposed estrogenicity in baboons

An efficient model of human endometriosis by induced unopposed estrogenicity in baboons

https://doi.org/10.18632/oncotarget.7516

Hareesh B. Nair, Robert Baker, Michael A. Owston, Renee Escalona, Edward J. Dick, John L. VandeBerg,  and Klaus J. Nickisch
10857-10869
Abstract  |  PDF  |  HTML  |  Order a Reprint

miR-19b attenuates H2O2-induced apoptosis in rat H9C2 cardiomyocytes via targeting PTEN

miR-19b attenuates H2O2-induced apoptosis in rat H9C2 cardiomyocytes via targeting PTEN

https://doi.org/10.18632/oncotarget.7678

Jiahong Xu, Yu Tang, Yihua Bei, Shengguang Ding, Lin Che, Jianhua Yao, Hongbao Wang, Dongchao Lv,  and Junjie Xiao
10870-10878
Abstract  |  PDF  |  HTML  |  Order a Reprint

Acidic leucine-rich nuclear phosphoprotein-32A (ANP32A) association with lymph node metastasis predicts poor survival in oral squamous cell carcinoma patients

Acidic leucine-rich nuclear phosphoprotein-32A (ANP32A) association with lymph node metastasis predicts poor survival in oral squamous cell carcinoma patients

https://doi.org/10.18632/oncotarget.7681

Bharath Kumar Velmurugan, Kun-Tu Yeh, Chien-Hung Lee, Shu-Hui Lin, Mei-Chung Chin, Shang-Lun Chiang, Zhi-Hong Wang, Chun-Hung Hua, Ming-Hsui Tsai, Jan-Gowth Chang,  and Ying-Chin Ko
10879-10890
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Research Papers: Immunology

The impact of ranitidine on monocyte responses in the context of solid tumors

The impact of ranitidine on monocyte responses in the context of solid tumors

https://doi.org/10.18632/oncotarget.7211

Ava Vila-Leahey, Dakota Rogers,  and Jean S. Marshall
10891-10904
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Immunogenicity and safety of xenogeneic vascular endothelial growth factor receptor-2 DNA vaccination in mice and dogs

Immunogenicity and safety of xenogeneic vascular endothelial growth factor receptor-2 DNA vaccination in mice and dogs

https://doi.org/10.18632/oncotarget.7265

Sofie Denies, Laetitia Cicchelero, Ingeborgh Polis,  and Niek N. Sanders
10905-10916
Abstract  |  PDF  |  HTML  |  Order a Reprint

First in-depth analysis of the novel Th2-type cytokines in salmonid fish reveals distinct patterns of expression and modulation but overlapping bioactivities

First in-depth analysis of the novel Th2-type cytokines in salmonid fish reveals distinct patterns of expression and modulation but overlapping bioactivities

https://doi.org/10.18632/oncotarget.7295

Tiehui Wang, Petronella Johansson, Beatriz Abós, Amy Holt, Carolina Tafalla, Youshen Jiang, Alex Wang, Qiaoqing Xu, Zhitao Qi, Wenshu Huang, Maria M. Costa, Patricia Diaz-Rosales, Jason W. Holland,  and Christopher J. Secombes
10917-10946
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Compensatory roles of CD8+ T cells and plasmacytoid dendritic cells in gut immune regulation for reduced function of CD4+ Tregs

Compensatory roles of CD8+ T cells and plasmacytoid dendritic cells in gut immune regulation for reduced function of CD4+ Tregs

https://doi.org/10.18632/oncotarget.7510

Young-In Kim, Bo-Ra Lee, Jae-Hee Cheon, Bo-Eun Kwon, Mi-Na Kweon, Hyun-Jeong Ko,  and Sun-Young Chang
10947-10961
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Removal of regulatory T cells prevents secondary chronic infection but increases the mortality of subsequent sub-acute infection in sepsis mice

Removal of regulatory T cells prevents secondary chronic infection but increases the mortality of subsequent sub-acute infection in sepsis mice

https://doi.org/10.18632/oncotarget.7682

Ruichao Huo, Lili Wang, Xiaoya Wang, Yong Zhao, Yi Wang, Xiaomin Zhao, Lingling Chang, Shan-lu Liu, Dewen Tong, Hai Zhang,  and Yong Huang
10962-10975
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Epigenetic regulation of HGK/MAP4K4 in T cells of type 2 diabetes patients

Epigenetic regulation of HGK/MAP4K4 in T cells of type 2 diabetes patients

https://doi.org/10.18632/oncotarget.7686

Huai-Chia Chuang, Jun-Sing Wang, I-Te Lee, Wayne H-H. Sheu,  and Tse-Hua Tan
10976-10989
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

New pathogen-specific immunoPET/MR tracer for molecular imaging of a systemic bacterial infection

New pathogen-specific immunoPET/MR tracer for molecular imaging of a systemic bacterial infection

https://doi.org/10.18632/oncotarget.7770

Stefan Wiehr, Philipp Warnke, Anna-Maria Rolle, Monika Schütz, Philipp Oberhettinger, Ursula Kohlhofer, Leticia Quintanilla-Martinez, Andreas Maurer, Christopher Thornton, Frederic Boschetti, Gerald Reischl, Ingo B. Autenrieth, Bernd J. Pichler,  and Stella E. Autenrieth
10990-11001
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Reviews

Cancer stem cells and signaling pathways in radioresistance

Cancer stem cells and signaling pathways in radioresistance

https://doi.org/10.18632/oncotarget.6760

Lei Chang, Peter Graham, Jingli Hao, Jie Ni, Junli Deng, Joseph Bucci, David Malouf, David Gillatt,  and Yong Li
11002-11017
Abstract  |  PDF  |  HTML  |  Order a Reprint

Aldehyde dehydrogenase 1A1 in stem cells and cancer

Aldehyde dehydrogenase 1A1 in stem cells and cancer

https://doi.org/10.18632/oncotarget.6920

Hiroyuki Tomita, Kaori Tanaka, Takuji Tanaka,  and Akira Hara
11018-11032
Abstract  |  PDF  |  HTML  |  Order a Reprint

The role of small adaptor proteins in the control of oncogenic signaling driven by tyrosine kinases in human cancer

The role of small adaptor proteins in the control of oncogenic signaling driven by tyrosine kinases in human cancer

https://doi.org/10.18632/oncotarget.6929

Cécile Naudin, Clément Chevalier,  and Serge Roche
11033-11055
Abstract  |  PDF  |  HTML  |  Order a Reprint

Research Papers

Gain-of-function miRNA signature by mutant p53 associates with poor cancer outcome

Gain-of-function miRNA signature by mutant p53 associates with poor cancer outcome

https://doi.org/10.18632/oncotarget.7090

Yao Zhang, Ye Hu, Jing-Yuan Fang,  and Jie Xu
11056-11066
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Oxidation of heat shock protein 60 and protein disulfide isomerase activates ERK and migration of human hepatocellular carcinoma HepG2

Oxidation of heat shock protein 60 and protein disulfide isomerase activates ERK and migration of human hepatocellular carcinoma HepG2

https://doi.org/10.18632/oncotarget.7093

Chung-Yi Lin, Chi-Tan Hu, Chuan-Chu Cheng, Ming-Che Lee, Siou-Mei Pan, Teng-Yi Lin,  and Wen-Sheng Wu
11067-11082
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Tumor-infiltrating macrophages express interleukin-25 and predict a favorable prognosis in patients with gastric cancer after radical resection

Tumor-infiltrating macrophages express interleukin-25 and predict a favorable prognosis in patients with gastric cancer after radical resection

https://doi.org/10.18632/oncotarget.7095

Jinqing Li, Yuan Liao, Tong Ding, Bo Wang, Xingjuan Yu, Yifan Chu, Jing Xu,  and Limin Zheng
11083-11093
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Loss of oncogenic miR-155 in tumor cells promotes tumor growth by enhancing C/EBP-β-mediated MDSC infiltration

Loss of oncogenic miR-155 in tumor cells promotes tumor growth by enhancing C/EBP-β-mediated MDSC infiltration

https://doi.org/10.18632/oncotarget.7150

Sinae Kim, Jin Hoi Song, Seokho Kim, Peng Qu, Betty K. Martin, Waheed S. Sehareen, Diana C. Haines, Pengnian C. Lin, Shyam K. Sharan,  and Suhwan Chang
11094-11112
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Overexpression of lipocalin 2 in human cervical cancer enhances tumor invasion

Overexpression of lipocalin 2 in human cervical cancer enhances tumor invasion

https://doi.org/10.18632/oncotarget.7096

I-Hsiao Chung, Tzu-I Wu, Chia-Jung Liao, Jin-Yo Hu, Yang-Hsiang Lin, Pei-ju Tai, Chyong-Huey Lai,  and Kwang-Huei Lin
11113-11126
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Aberrant epigenetic regulation in clear cell sarcoma of the kidney featuring distinct DNA hypermethylation and EZH2 overexpression

Aberrant epigenetic regulation in clear cell sarcoma of the kidney featuring distinct DNA hypermethylation and EZH2 overexpression

https://doi.org/10.18632/oncotarget.7152

Jenny Karlsson, Anders Valind, Caroline Jansson, Maureen J. O’Sullivan, Linda Holmquist Mengelbier,  and David Gisselsson
11127-11136
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Bevacizumab specifically decreases elevated levels of circulating KIT+CD11b+ cells and IL-10 in metastatic breast cancer patients

Bevacizumab specifically decreases elevated levels of circulating KIT+CD11b+ cells and IL-10 in metastatic breast cancer patients

https://doi.org/10.18632/oncotarget.7097

Sarah Cattin, Benoît Fellay, Sylvain Pradervand, Andreas Trojan, Thomas Ruhstaller, Curzio Rüegg,  and Gregor Fürstenberger
11137-11150
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A systematic review of serum autoantibodies as biomarkers for pancreatic cancer detection

A systematic review of serum autoantibodies as biomarkers for pancreatic cancer detection

https://doi.org/10.18632/oncotarget.7098

Karin Dumstrei, Hongda Chen,  and Hermann Brenner
11151-11164
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Distinct lymphocyte antigens 6 (Ly6) family members Ly6D, Ly6E, Ly6K and Ly6H drive tumorigenesis and clinical outcome

Distinct lymphocyte antigens 6 (Ly6) family members Ly6D, Ly6E, Ly6K and Ly6H drive tumorigenesis and clinical outcome

https://doi.org/10.18632/oncotarget.7163

Linlin Luo, Peter McGarvey, Subha Madhavan, Rakesh Kumar, Yuriy Gusev,  and Geeta Upadhyay
11165-11193
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

EZH2 promotes cell migration and invasion but not alters cell proliferation by suppressing E-cadherin, partly through association with MALAT-1 in pancreatic cancer

EZH2 promotes cell migration and invasion but not alters cell proliferation by suppressing E-cadherin, partly through association with MALAT-1 in pancreatic cancer

https://doi.org/10.18632/oncotarget.7156

Ting Han, Feng Jiao, Hai Hu, Cuncun Yuan, Lei Wang, Zi-Liang Jin, Weifeng Song,  and Li-Wei Wang
11194-11207
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Smad4-dependent suppressor pituitary homeobox 2 promotes PPP2R2A-mediated inhibition of Akt pathway in pancreatic cancer

Smad4-dependent suppressor pituitary homeobox 2 promotes PPP2R2A-mediated inhibition of Akt pathway in pancreatic cancer

https://doi.org/10.18632/oncotarget.7158

Qi Wang, Juanjuan Li, Wei Wu, Ruizhe Shen, He Jiang, Yuting Qian, Yanping Tang, Tingting Bai, Sheng Wu, Lumin Wei, Yi Zang, Ji Zhang,  and Lifu Wang
11208-11222
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Brother of the regulator of the imprinted site (BORIS) variant subfamily 6 is involved in cervical cancer stemness and can be a target of immunotherapy

Brother of the regulator of the imprinted site (BORIS) variant subfamily 6 is involved in cervical cancer stemness and can be a target of immunotherapy

https://doi.org/10.18632/oncotarget.7165

Takuya Asano, Yoshihiko Hirohashi, Toshihiko Torigoe, Tasuku Mariya, Ryota Horibe, Takafumi Kuroda, Yuta Tabuchi, Hiroshi Saijo, Kazuyo Yasuda, Masahito Mizuuchi, Akari Takahashi, Hiroko Asanuma, Tadashi Hasegawa, Tsuyoshi Saito,  and Noriyuki Sato
11223-11237
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

HIF2α contributes to antiestrogen resistance via positive bilateral crosstalk with EGFR in breast cancer cells

HIF2α contributes to antiestrogen resistance via positive bilateral crosstalk with EGFR in breast cancer cells

https://doi.org/10.18632/oncotarget.7167

Muhammad Wasi Alam, Camilla Ulrika Persson, Susann Reinbothe, Julhash U. Kazi, Lars Rönnstrand, Caroline Wigerup, Henrik Jorn Ditzel, Anne E. Lykkesfeldt, Sven Påhlman,  and Annika Jögi
11238-11250
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Mucin glycosylating enzyme GALNT2 suppresses malignancy in gastric adenocarcinoma by reducing MET phosphorylation

Mucin glycosylating enzyme GALNT2 suppresses malignancy in gastric adenocarcinoma by reducing MET phosphorylation

https://doi.org/10.18632/oncotarget.7081

Shin-Yun Liu, Chia-Tung Shun, Kuan-Yu Hung, Hsueh-Fen Juan, Chia-Lang Hsu, Min-Chuan Huang,  and I-Rue Lai
11251-11262
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Identification of quinazoline compounds as novel potent inhibitors of Wnt/β-catenin signaling in colorectal cancer cells

Identification of quinazoline compounds as novel potent inhibitors of Wnt/β-catenin signaling in colorectal cancer cells

https://doi.org/10.18632/oncotarget.7019

Yonghe Li, Wenyan Lu, Surendra K. Saini, Omar Moukha-Chafiq, Vibha Pathak,  and Subramaniam Ananthan
11263-11270
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Long non-coding RNA FEZF1-AS1 facilitates cell proliferation and migration in colorectal carcinoma

Long non-coding RNA FEZF1-AS1 facilitates cell proliferation and migration in colorectal carcinoma

https://doi.org/10.18632/oncotarget.7168

Na Chen, Dan Guo, Qiong Xu, Minhui Yang, Dan Wang, Man Peng, Yanqing Ding, Shuang Wang,  and Jun Zhou
11271-11283
Abstract  |  PDF  |  HTML  |  Order a Reprint

SIRT1 increases YAP- and MKK3-dependent p38 phosphorylation in mouse liver and human hepatocellular carcinoma

SIRT1 increases YAP- and MKK3-dependent p38 phosphorylation in mouse liver and human hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.7022

Yulan Wang, Ran Cui, Xiao Zhang, Yongxia Qiao, Xiangfan Liu, Yefei Chang, Yongchun Yu, Fenyong Sun,  and Jiayi Wang
11284-11298
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Heparanase promotes myeloma progression by inducing mesenchymal features and motility of myeloma cells

Heparanase promotes myeloma progression by inducing mesenchymal features and motility of myeloma cells

https://doi.org/10.18632/oncotarget.7170

Juan Li, Qianying Pan, Patrick D. Rowan, Timothy N. Trotter, Deniz Peker, Kellie M. Regal, Amjad Javed, Larry J. Suva,  and Yang Yang
11299-11309
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Dosing de novo combinations of two targeted drugs: Towards a customized precision medicine approach to advanced cancers

Dosing de novo combinations of two targeted drugs: Towards a customized precision medicine approach to advanced cancers

https://doi.org/10.18632/oncotarget.7023

Sariah Liu, Mina Nikanjam,  and Razelle Kurzrock
11310-11320
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

EIF2S3Y suppresses the pluripotency state and promotes the proliferation of mouse embryonic stem cells

EIF2S3Y suppresses the pluripotency state and promotes the proliferation of mouse embryonic stem cells

https://doi.org/10.18632/oncotarget.7187

Na Li, Hailong Mu, Liming Zheng, Bo Li, Chongyang Wu, Bowen Niu, Qiaoyan Shen, Xin He,  and Jinlian Hua
11321-11331
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Histone acetyltransferase inhibitor CPTH6 preferentially targets lung cancer stem-like cells

Histone acetyltransferase inhibitor CPTH6 preferentially targets lung cancer stem-like cells

https://doi.org/10.18632/oncotarget.7238

Marta Di Martile, Marianna Desideri, Teresa De Luca, Chiara Gabellini, Simonetta Buglioni, Adriana Eramo, Giovanni Sette, Michele Milella, Dante Rotili, Antonello Mai, Simone Carradori, Daniela Secci, Ruggero De Maria, Donatella Del Bufalo,  and Daniela Trisciuoglio
11332-11348
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Mutual amplification of HNF4α and IL-1R1 composes an inflammatory circuit in Helicobacter pylori associated gastric carcinogenesis

Mutual amplification of HNF4α and IL-1R1 composes an inflammatory circuit in Helicobacter pylori associated gastric carcinogenesis

https://doi.org/10.18632/oncotarget.7239

Lin Ma, Jiping Zeng, Qing Guo, Xiuming Liang, Li Shen, Shuyan Li, Yundong Sun, Wenjuan Li, Shili Liu, Han Yu, Chunyan Chen,  and Jihui Jia
11349-11363
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Human telomerase reverse transcriptase (hTERT) promotes gastric cancer invasion through cooperating with c-Myc to upregulate heparanase expression

Human telomerase reverse transcriptase (hTERT) promotes gastric cancer invasion through cooperating with c-Myc to upregulate heparanase expression

https://doi.org/10.18632/oncotarget.6575

Bo Tang, Rui Xie, Yong Qin, Yu-Feng Xiao, Xin Yong, Lei Zheng, Hui Dong,  and Shi-Ming Yang
11364-11379
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Efficacy of continued cetuximab for unresectable metastatic colorectal cancer after disease progression during first-line cetuximab-based chemotherapy: a retrospective cohort study

Efficacy of continued cetuximab for unresectable metastatic colorectal cancer after disease progression during first-line cetuximab-based chemotherapy: a retrospective cohort study

https://doi.org/10.18632/oncotarget.7193

Qingyang Feng, Ye Wei, Li Ren, Peng Zheng, Yiyi Yu, Qinghai Ye, Jianyong Ding, Jingwen Chen, Wenju Chang, Yunshi Zhong, Dexiang Zhu, Qi Lin, Liangliang Yang, Xinyu Qin,  and Jianmin Xu
11380-11396
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Pinin interacts with C-terminal binding proteins for RNA alternative splicing and epithelial cell identity of human ovarian cancer cells

Pinin interacts with C-terminal binding proteins for RNA alternative splicing and epithelial cell identity of human ovarian cancer cells

https://doi.org/10.18632/oncotarget.7242

Yanli Zhang, Jamie Sui-Lam Kwok, Pui-Wah Choi, Minghua Liu, Junzheng Yang, Margit Singh, Shu-Kay Ng, William R. Welch, Michael G. Muto, Stephen KW Tsui, Stephen P. Sugrue, Ross S. Berkowitz,  and Shu-Wing Ng
11397-11411
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Oncogenic potential of histone-variant H2A.Z.1 and its regulatory role in cell cycle and epithelial-mesenchymal transition in liver cancer

Oncogenic potential of histone-variant H2A.Z.1 and its regulatory role in cell cycle and epithelial-mesenchymal transition in liver cancer

https://doi.org/10.18632/oncotarget.7194

Hee Doo Yang, Pum-Joon Kim, Jung Woo Eun, Qingyu Shen, Hyung Seok Kim, Woo Chan Shin, Young Min Ahn, Won Sang Park, Jung Young Lee,  and Suk Woo Nam
11412-11423
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Polycomb repressor complex 1 promotes gene silencing through H2AK119 mono-ubiquitination in acinar-to-ductal metaplasia and pancreatic cancer cells

Polycomb repressor complex 1 promotes gene silencing through H2AK119 mono-ubiquitination in acinar-to-ductal metaplasia and pancreatic cancer cells

https://doi.org/10.18632/oncotarget.6717

Simone Benitz, Ivonne Regel, Tobias Reinhard, Anna Popp, Isabell Schäffer, Susanne Raulefs, Bo Kong, Irene Esposito, Christoph W. Michalski,  and Jörg Kleeff
11424-11433
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Examining plasma microRNA markers for colorectal cancer at different stages

Examining plasma microRNA markers for colorectal cancer at different stages

https://doi.org/10.18632/oncotarget.7196

Yan Sun, Yuexin Liu, David Cogdell, George A. Calin, Baocun Sun, Scott Kopetz, Stanley R. Hamilton,  and Wei Zhang
11434-11449
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Frequency of CD4+CD25+Foxp3+ cells in peripheral blood in relation to urinary bladder cancer malignancy indicators before and after surgical removal

Frequency of CD4+CD25+Foxp3+ cells in peripheral blood in relation to urinary bladder cancer malignancy indicators before and after surgical removal

https://doi.org/10.18632/oncotarget.7199

Wojciech Jóźwicki, Anna A. Brożyna, Jerzy Siekiera,  and Andrzej T. Slominski
11450-11462
Abstract  |  PDF  |  HTML  |  Order a Reprint

Reduced RKIP enhances nasopharyngeal carcinoma radioresistance by increasing ERK and AKT activity

Reduced RKIP enhances nasopharyngeal carcinoma radioresistance by increasing ERK and AKT activity

https://doi.org/10.18632/oncotarget.7201

Li Yuan, Hong-Mei Yi, Hong Yi, Jia-Quan Qu, Jin-Feng Zhu, Li-Na Li, Ta Xiao, Zhen Zheng, Shan-Shan Lu,  and Zhi-Qiang Xiao
11463-11477
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Brachyury identifies a class of enteroendocrine cells in normal human intestinal crypts and colorectal cancer

Brachyury identifies a class of enteroendocrine cells in normal human intestinal crypts and colorectal cancer

https://doi.org/10.18632/oncotarget.7202

Jana Jezkova, Jason S. Williams, Filipe Pinto, Stephen J. Sammut, Geraint T. Williams, Simon Gollins, Ramsay J. McFarlane, Rui Manuel Reis,  and Jane A. Wakeman
11478-11486
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Non-coding RNA LINC00857 is predictive of poor patient survival and promotes tumor progression via cell cycle regulation in lung cancer

Non-coding RNA LINC00857 is predictive of poor patient survival and promotes tumor progression via cell cycle regulation in lung cancer

https://doi.org/10.18632/oncotarget.7203

Lihui Wang, Yanli He, Weijun Liu, Shengbin Bai, Lei Xiao, Jie Zhang, Saravana M. Dhanasekaran, Zhuwen Wang, Shanker Kalyana-Sundaram, O. Alejandro Balbin, Sudhanshu Shukla, Yi Lu, Jules Lin, Rishindra M. Reddy, Philip W. Carrott, Jr., William R. Lynch, Andrew C. Chang, Arul M. Chinnaiyan, David G. Beer, Jian Zhang,  and Guoan Chen
11487-11499
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Defining specificity and on-target activity of BH3-mimetics using engineered B-ALL cell lines

Defining specificity and on-target activity of BH3-mimetics using engineered B-ALL cell lines

https://doi.org/10.18632/oncotarget.7204

Brian Koss, Jeremy Ryan, Amit Budhraja, Katherine Szarama, Xue Yang, Madhavi Bathina, Michael H. Cardone, Zaneta Nikolovska-Coleska, Anthony Letai,  and Joseph T. Opferman
11500-11511
Abstract  |  PDF  |  HTML  |  Order a Reprint

Role of MIF/CD74 signaling pathway in the development of pleural mesothelioma

Role of MIF/CD74 signaling pathway in the development of pleural mesothelioma

https://doi.org/10.18632/oncotarget.7314

Cintia D’Amato-Brito, Davide Cipriano, Didier J. Colin, Stéphane Germain, Yann Seimbille, John H. Robert, Frédéric Triponez,  and Véronique Serre-Beinier
11512-11525
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Integrative radiogenomic analysis for multicentric radiophenotype in glioblastoma

Integrative radiogenomic analysis for multicentric radiophenotype in glioblastoma

https://doi.org/10.18632/oncotarget.7115

Doo-Sik Kong, Jinkuk Kim, In-Hee Lee, Sung Tae Kim, Ho Jun Seol, Jung-Il Lee, Woong-Yang Park, Gyuha Ryu, Zichen Wang, Avi Ma’ayan,  and Do-Hyun Nam
11526-11538
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Identification of novel pathways linking epithelial-to-mesenchymal transition with resistance to HER2-targeted therapy

Identification of novel pathways linking epithelial-to-mesenchymal transition with resistance to HER2-targeted therapy

https://doi.org/10.18632/oncotarget.7317

Helen Creedon, Laura Gómez-Cuadrado, Žygimantė Tarnauskaitė, Jozef Balla, Marta Canel, Kenneth G. MacLeod, Bryan Serrels, Craig Fraser, Asier Unciti-Broceta, Natasha Tracey, Thierry Le Bihan, Teresa Klinowska, Andrew H. Sims, Adam Byron,  and Valerie G. Brunton
11539-11552
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Regulation of laryngeal squamous cell cancer progression by the lncRNA H19/miR-148a-3p/DNMT1 axis

Regulation of laryngeal squamous cell cancer progression by the lncRNA H19/miR-148a-3p/DNMT1 axis

https://doi.org/10.18632/oncotarget.7270

Tianyi Wu, Lingmei Qu, Guoqing He, Linli Tian, Liang Li, Han Zhou, Qian Jin, Jingyuan Ren, Yu Wang, Jingting Wang, Xuan Kan, Ming Liu, Jia Shen, Mian Guo,  and Yanan Sun
11553-11566
Abstract  |  PDF  |  HTML  |  Order a Reprint

HIF-3α1 promotes colorectal tumor cell growth by activation of JAK-STAT3 signaling

HIF-3α1 promotes colorectal tumor cell growth by activation of JAK-STAT3 signaling

https://doi.org/10.18632/oncotarget.7272

Xiang Xue, Kylie Jungles, Gunseli Onder, Jalal Samhoun, Balázs Győrffy,  and Karin M. Hardiman
11567-11579
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A strategy to eradicate well-developed Krebs-2 ascites in mice

A strategy to eradicate well-developed Krebs-2 ascites in mice

https://doi.org/10.18632/oncotarget.7311

Ekaterina A. Potter, Evgenia V. Dolgova, Anastasia S. Proskurina, Alexandra M. Minkevich, Yaroslav R. Efremov, Oleg S. Taranov, Vladimir V. Omigov, Valeriy P. Nikolin, Nelly A. Popova, Sergey I. Bayborodin, Alexander A. Ostanin, Elena R. Chernykh, Nikolay A. Kolchanov, Mikhail A. Shurdov,  and Sergey S. Bogachev
11580-11594
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MicroRNA-150 suppresses cell proliferation and metastasis in hepatocellular carcinoma by inhibiting the GAB1-ERK axis

MicroRNA-150 suppresses cell proliferation and metastasis in hepatocellular carcinoma by inhibiting the GAB1-ERK axis

https://doi.org/10.18632/oncotarget.7292

Wei Sun, Zhuochao Zhang, Jianlin Wang, Runze Shang, Liang Zhou, Xing Wang, Juanli Duan, Bai Ruan, Yuan Gao, Bin Dai, Shibin Qu, Wei Liu, Rui Ding, Lin Wang, Desheng Wang,  and Kefeng Dou
11595-11608
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Downregulation of TFAM inhibits the tumorigenesis of non-small cell lung cancer by activating ROS-mediated JNK/p38MAPK signaling and reducing cellular bioenergetics

Downregulation of TFAM inhibits the tumorigenesis of non-small cell lung cancer by activating ROS-mediated JNK/p38MAPK signaling and reducing cellular bioenergetics

https://doi.org/10.18632/oncotarget.7018

Deyao Xie, Xiaoyi Wu, Linhua Lan, Fugeng Shangguan, Xiaoming Lin, Fuhong Chen, Shan Xu, Ya Zhang, Zilei Chen, Kate Huang, Rongrong Wang, Lu Wang, Xiaoxiao Song, Yongzhang Liu,  and Bin Lu
11609-11624
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Dioxonaphthoimidazoliums AB1 and YM155 disrupt phosphorylation of p50 in the NF-κB pathway

Dioxonaphthoimidazoliums AB1 and YM155 disrupt phosphorylation of p50 in the NF-κB pathway

https://doi.org/10.18632/oncotarget.7299

Si Han Sherman Ho, Azhar Ali, Tan Min Chin,  and Mei Lin Go
11625-11636
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

miR-144-3p, a tumor suppressive microRNA targeting ETS-1 in laryngeal squamous cell carcinoma

miR-144-3p, a tumor suppressive microRNA targeting ETS-1 in laryngeal squamous cell carcinoma

https://doi.org/10.18632/oncotarget.7025

Si-Yi Zhang, Zhong-Ming Lu, Ye-Feng Lin, Liang-Si Chen, Xiao-Ning Luo, Xin-Han Song, Shao-Hua Chen,  and Yi-Long Wu
11637-11650
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Hypoxia induces TFE3 expression in head and neck squamous cell carcinoma

Hypoxia induces TFE3 expression in head and neck squamous cell carcinoma

https://doi.org/10.18632/oncotarget.7309

Zhi-Jun Sun, Guang-Tao Yu, Cong-Fa Huang, Lin-Lin Bu, Jian-Feng Liu, Si-Rui Ma, Wen-Feng Zhang, Bing Liu,  and Lu Zhang
11651-11663
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Substrate-specific effects of pirinixic acid derivatives on ABCB1-mediated drug transport

Substrate-specific effects of pirinixic acid derivatives on ABCB1-mediated drug transport

https://doi.org/10.18632/oncotarget.7345

Martin Michaelis, Florian Rothweiler, Mario Wurglics, Natália Aniceto, Michaela Dittrich, Heiko Zettl, Michael Wiese, Mark Wass, Taravat Ghafourian, Manfred Schubert-Zsilavecz,  and Jindrich Cinatl
11664-11676
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

CCL-34, a synthetic toll-like receptor 4 activator, modulates differentiation and maturation of myeloid dendritic cells

CCL-34, a synthetic toll-like receptor 4 activator, modulates differentiation and maturation of myeloid dendritic cells

https://doi.org/10.18632/oncotarget.7315

Shu-Ling Fu, Chun-Cheng Lin, Ming-Ling Hsu, Sheng-Hung Liu, Yu-Chuen Huang,  and Yu-Jen Chen
11677-11686
Abstract  |  PDF  |  HTML  |  Order a Reprint

Antidepressants in association with reducing risk of oral cancer occurrence: a nationwide population-based cohort and nested case-control studies

Antidepressants in association with reducing risk of oral cancer occurrence: a nationwide population-based cohort and nested case-control studies

https://doi.org/10.18632/oncotarget.7049

Chia-Min Chung, Tzer-Min Kuo, Shang-Lun Chiang, Zhi-Hong Wang, Chung-Chieh Hung, Hsien-Yuan Lane, Chiu-Shong Liu,  and Ying-Chin Ko
11687-11695
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Long non-coding RNA LINC01133 represses KLF2, P21 and E-cadherin transcription through binding with EZH2, LSD1 in non small cell lung cancer

Long non-coding RNA LINC01133 represses KLF2, P21 and E-cadherin transcription through binding with EZH2, LSD1 in non small cell lung cancer

https://doi.org/10.18632/oncotarget.7077

Chongshuang Zang, Feng-qi Nie, Qian Wang, Ming Sun, Wei Li, Jing He, Meiling Zhang,  and Kai-hua Lu
11696-11707
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Overcoming chemo/radio-resistance of pancreatic cancer by inhibiting STAT3 signaling

Overcoming chemo/radio-resistance of pancreatic cancer by inhibiting STAT3 signaling

https://doi.org/10.18632/oncotarget.7336

Xiaoqing Wu, Wenhua Tang, Rebecca T. Marquez, Ke Li, Chad A. Highfill, Fengtian He, Jiqin Lian, Jiayuh Lin, James R. Fuchs, Min Ji, Ling Li,  and Liang Xu
11708-11723
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

XPG rs2296147 T>C polymorphism predicted clinical outcome in colorectal cancer

XPG rs2296147 T>C polymorphism predicted clinical outcome in colorectal cancer

https://doi.org/10.18632/oncotarget.7352

Fang Wang, Shao-Dan Zhang, Hong-Mei Xu, Jin-Hong Zhu, Rui-Xi Hua, Wen-Qiong Xue, Xi-Zhao Li, Tong-Min Wang, Jing He,  and Wei-Hua Jia
11724-11732
Abstract  |  PDF  |  HTML  |  Order a Reprint

Long non-coding RNA MALAT1 increases AKAP-9 expression by promoting SRPK1-catalyzed SRSF1 phosphorylation in colorectal cancer cells

Long non-coding RNA MALAT1 increases AKAP-9 expression by promoting SRPK1-catalyzed SRSF1 phosphorylation in colorectal cancer cells

https://doi.org/10.18632/oncotarget.7367

Zhi-Yan Hu, Xiao-Yan Wang, Wen-bin Guo, Lin-Ying Xie, Yu-qi Huang, Yan-Ping Liu, Li-Wei Xiao, Sheng-Nan Li, Hui-Fang Zhu, Zu-Guo Li,  and Heping Kan
11733-11743
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint


Copyright © 2017 Impact Journals
Impact Journals is a registered trademark of Impact Journals, LLC