Oncotarget

Vol 7, No 9

March 1, 2016

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About The Cover

Lipid tethering of breast tumor cells enables real-time imaging of free-floating cell dynamics and drug response. See Chakrabarti et al.

Image courtesy of S. Martin and K. Chakrabarti

Table of Contents

Editorial

Neurons and guidance cues in retinal vascular diseases

Neurons and guidance cues in retinal vascular diseases

DOI: 10.18632/oncotarget.7413

Ariel Wilson,  and Przemyslaw Sapieha
9618-9619
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Research Papers: Gerotarget (Focus on Aging)

Improved cell metabolism prolongs photoreceptor survival upon retinal-pigmented epithelium loss in the sodium iodate induced model of geographic atrophy

Improved cell metabolism prolongs photoreceptor survival upon retinal-pigmented epithelium loss in the sodium iodate induced model of geographic atrophy

DOI: 10.18632/oncotarget.7330

Marina Zieger,  and Claudio Punzo
9620-9633
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

GDF15 contributes to radiation-induced senescence through the ROS-mediated p16 pathway in human endothelial cells

GDF15 contributes to radiation-induced senescence through the ROS-mediated p16 pathway in human endothelial cells

DOI: 10.18632/oncotarget.7457

Hyejin Park, Chun-Ho Kim, Jae-Hoon Jeong, Myungjin Park,  and Kwang Seok Kim
9634-9644
Abstract  |   PDF  |  HTML  |  Order a Reprint

Research Papers: Pathology

A follow-up analysis of positron emission tomography/computed tomography in detecting hidden malignancies at the time of diagnosis of membranous nephropathy

A follow-up analysis of positron emission tomography/computed tomography in detecting hidden malignancies at the time of diagnosis of membranous nephropathy

DOI: 10.18632/oncotarget.7506

Zhonglin Feng, Shuxia Wang, Yanlin Huang, Xinling Liang, Wei Shi,  and Bin Zhang
9645-9651
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Research Papers: Immunology

Lipopolysaccharide derived from the digestive tract activates inflammatory gene expression and inhibits casein synthesis in the mammary glands of lactating dairy cows

Lipopolysaccharide derived from the digestive tract activates inflammatory gene expression and inhibits casein synthesis in the mammary glands of lactating dairy cows

DOI: 10.18632/oncotarget.7371

Kai Zhang, Guangjun Chang, Tianle Xu, Lei Xu, Junfei Guo, Di Jin,  and Xiangzhen Shen
9652-9665
Abstract  |   PDF  |  HTML  |  Order a Reprint

Research Papers

The genetic and genomic background of multiple myeloma patients achieving complete response after induction therapy with bortezomib, thalidomide and dexamethasone (VTD)

The genetic and genomic background of multiple myeloma patients achieving complete response after induction therapy with bortezomib, thalidomide and dexamethasone (VTD)

DOI: 10.18632/oncotarget.5718

Carolina Terragna, Daniel Remondini, Marina Martello, Elena Zamagni, Lucia Pantani, Francesca Patriarca, Annalisa Pezzi, Giuseppe Levi, Massimo Offidani, Ilaria Proserpio, Giovanni De Sabbata, Paola Tacchetti, Clotilde Cangialosi, Fabrizio Ciambelli, Clara Virginia Viganò, Flores Angela Dico, Barbara Santacroce, Enrica Borsi, Annamaria Brioli, Giulia Marzocchi, Gastone Castellani, Giovanni Martinelli, Antonio Palumbo,  and Michele Cavo
9666-9679
Abstract  |    |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Guanylate binding protein-1 mediates EGFRvIII and promotes glioblastoma growth in vivo but not in vitro

Guanylate binding protein-1 mediates EGFRvIII and promotes glioblastoma growth in vivo but not in vitro

DOI: 10.18632/oncotarget.7109

Qing Lan, Aidong Wang, Yanwei Cheng, Akitaki Mukasa, Jiawei Ma, Lei Hong, Shuye Yu, Lili Sun, Qiang Huang, Benjamin Purow,  and Ming Li
9680-9691
Abstract  |    |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Yap1 promotes the survival and self-renewal of breast tumor initiating cells via inhibiting Smad3 signaling

Yap1 promotes the survival and self-renewal of breast tumor initiating cells via inhibiting Smad3 signaling

DOI: 10.18632/oncotarget.6655

Jian-Guo Sun, Xie-Wan Chen, Lu-Ping Zhang, Jiang Wang,  and Max Diehn
9692-9706
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Detection rate of actionable mutations in diverse cancers using a biopsy-free (blood) circulating tumor cell DNA assay

Detection rate of actionable mutations in diverse cancers using a biopsy-free (blood) circulating tumor cell DNA assay

DOI: 10.18632/oncotarget.7110

Maria Schwaederle, Hatim Husain, Paul T. Fanta, David E. Piccioni, Santosh Kesari, Richard B. Schwab, Kimberly C. Banks, Richard B. Lanman, AmirAli Talasaz, Barbara A. Parker,  and Razelle Kurzrock
9707-9717
Abstract  |    |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The dual targeting of insulin and insulin-like growth factor 1 receptor enhances the mTOR inhibitor-mediated antitumor efficacy in hepatocellular carcinoma

The dual targeting of insulin and insulin-like growth factor 1 receptor enhances the mTOR inhibitor-mediated antitumor efficacy in hepatocellular carcinoma

DOI: 10.18632/oncotarget.6836

Claudia Pivonello, Mariarosaria Negri, Maria Cristina De Martino, Maria Napolitano, Cristina de Angelis, Donatella Paola Provvisiero, Gaia Cuomo, Renata Simona Auriemma, Chiara Simeoli, Francesco Izzo, Annamaria Colao, Leo J. Hofland,  and Rosario Pivonello
9718-9731
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

PARP1 inhibition radiosensitizes HNSCC cells deficient in homologous recombination by disabling the DNA replication fork elongation response

PARP1 inhibition radiosensitizes HNSCC cells deficient in homologous recombination by disabling the DNA replication fork elongation response

DOI: 10.18632/oncotarget.6947

Stephanie Wurster, Fabian Hennes, Ann C. Parplys, Jasna I. Seelbach, Wael Y. Mansour, Alexandra Zielinski, Cordula Petersen, Till S. Clauditz, Adrian Münscher, Anna A. Friedl,  and Kerstin Borgmann
9732-9741
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Zoledronate blocks geranylgeranylation not farnesylation to suppress human osteosarcoma U2OS cells metastasis by EMT via Rho A activation and FAK-inhibited JNK and p38 pathways

Zoledronate blocks geranylgeranylation not farnesylation to suppress human osteosarcoma U2OS cells metastasis by EMT via Rho A activation and FAK-inhibited JNK and p38 pathways

DOI: 10.18632/oncotarget.7138

Hsin-Lin Cheng, Chiao-Wen Lin, Jia-Sin Yang, Ming-Ju Hsieh, Shun-Fa Yang,  and Ko-Hsiu Lu
9742-9758
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Genetic evaluation of BRCA1-A complex genes with triple-negative breast cancer susceptibility in Chinese women

Genetic evaluation of BRCA1-A complex genes with triple-negative breast cancer susceptibility in Chinese women

DOI: 10.18632/oncotarget.7112

Hong Ling, Shan Li, Yang Wu, Yi-Zi Zheng, Feng Qiao, Ling Yao, Zhi-Gang Cao, Fu-Gui Ye, Jiong Wu, Xin Hu, Bin Wang,  and Zhi-Ming Shao
9759-9772
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Long intergenic non-coding RNA 00152 promotes tumor cell cycle progression by binding to EZH2 and repressing p15 and p21 in gastric cancer

Long intergenic non-coding RNA 00152 promotes tumor cell cycle progression by binding to EZH2 and repressing p15 and p21 in gastric cancer

DOI: 10.18632/oncotarget.6949

Wen-ming Chen, Ming-de Huang, Dao-ping Sun, Rong Kong, Tong-peng Xu, Rui Xia, Er-bao Zhang,  and Yong-qian Shu
9773-9787
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Helicobacter pylori CagA induces tumor suppressor gene hypermethylation by upregulating DNMT1 via AKT-NFκB pathway in gastric cancer development

Helicobacter pylori CagA induces tumor suppressor gene hypermethylation by upregulating DNMT1 via AKT-NFκB pathway in gastric cancer development

DOI: 10.18632/oncotarget.7125

Bao-gui Zhang, Lei Hu, Ming-de Zang, He-xiao Wang, Wei Zhao, Jian-fang Li, Li-ping Su, Zhifeng Shao, Xiaodong Zhao, Zheng-gang Zhu, Min Yan,  and Bingya Liu
9788-9800
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Ablation of Neuropilin 1 from glioma-associated microglia and macrophages slows tumor progression

Ablation of Neuropilin 1 from glioma-associated microglia and macrophages slows tumor progression

DOI: 10.18632/oncotarget.6877

Jeremy T. Miyauchi, Danling Chen, Matthew Choi, Jillian C. Nissen, Kenneth R. Shroyer, Snezana Djordevic, Ian C. Zachary, David Selwood,  and Stella E. Tsirka
9801-9814
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Identification of stem-like cells and clinical significance of candidate stem cell markers in gastric cancer

Identification of stem-like cells and clinical significance of candidate stem cell markers in gastric cancer

DOI: 10.18632/oncotarget.6890

Xiaowei Zhang, Ruixi Hua, Xiaofeng Wang, Mingzhu Huang, Lu Gan, Zhenhua Wu, Jiejun Zhang, Hongqiang Wang, Yufan Cheng, Jin Li,  and Weijian Guo
9815-9831
Abstract  |   PDF  |  HTML  |  Order a Reprint

RB/PLK1-dependent induced pathway by SLAMF3 expression inhibits mitosis and control hepatocarcinoma cell proliferation

RB/PLK1-dependent induced pathway by SLAMF3 expression inhibits mitosis and control hepatocarcinoma cell proliferation

DOI: 10.18632/oncotarget.6954

Hicham Bouhlal, Hakim Ouled-Haddou, Véronique Debuysscher, Amrathlal Rabbind Singh, Christèle Ossart, Aline Reignier, Hakim Hocini, Gregory Fouquet, Mohammed Al Baghami, Mélanie Simoes Eugenio, Eric Nguyen-Khac, Jean-Marc Regimbeau,  and Ingrid Marcq
9832-9843
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Reelin promotes the adhesion and drug resistance of multiple myeloma cells via integrin β1 signaling and STAT3

Reelin promotes the adhesion and drug resistance of multiple myeloma cells via integrin β1 signaling and STAT3

DOI: 10.18632/oncotarget.7151

Liang Lin, Fan Yan, Dandan Zhao, Meng Lv, Xiaodong Liang, Hui Dai, Xiaodan Qin, Yan Zhang, Jie Hao, Xiuyuan Sun, Yanhui Yin, Xiaojun Huang, Jun Zhang, Jin Lu,  and Qing Ge
9844-9858
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The transcription factor GATA1 and the histone methyltransferase SET7 interact to promote VEGF-mediated angiogenesis and tumor growth and predict clinical outcome of breast cancer

The transcription factor GATA1 and the histone methyltransferase SET7 interact to promote VEGF-mediated angiogenesis and tumor growth and predict clinical outcome of breast cancer

DOI: 10.18632/oncotarget.7126

Yanan Zhang, Jie Liu, Jing Lin, Lei Zhou, Yuhua Song, Bo Wei, Xiaoli Luo, Zhida Chen, Yingjie Chen, Jiaxiu Xiong, Xiaojie Xu, Lihua Ding,  and Qinong Ye
9859-9875
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Inhibiting receptor tyrosine kinase AXL with small molecule inhibitor BMS-777607 reduces glioblastoma growth, migration, and invasion in vitro and in vivo

Inhibiting receptor tyrosine kinase AXL with small molecule inhibitor BMS-777607 reduces glioblastoma growth, migration, and invasion in vitro and in vivo

DOI: 10.18632/oncotarget.7130

Julia Onken, Robert Torka, Sören Korsing, Josefine Radke, Irina Kremenetskaia, Melina Nieminen, Xi Bai, Axel Ullrich, Frank Heppner,  and Peter Vajkoczy
9876-9889
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

JNK pathway inhibition selectively primes pancreatic cancer stem cells to TRAIL-induced apoptosis without affecting the physiology of normal tissue resident stem cells

JNK pathway inhibition selectively primes pancreatic cancer stem cells to TRAIL-induced apoptosis without affecting the physiology of normal tissue resident stem cells

DOI: 10.18632/oncotarget.7066

Alejandro Recio-Boiles, Matthias Ilmer, P. Robyn Rhea, Claudia Kettlun, Mitja L. Heinemann, Jennifer Ruetering, Jody Vykoukal,  and Eckhard Alt
9890-9906
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Rh2E2, a novel metabolic suppressor, specifically inhibits energy-based metabolism of tumor cells

Rh2E2, a novel metabolic suppressor, specifically inhibits energy-based metabolism of tumor cells

DOI: 10.18632/oncotarget.6934

Vincent Kam Wai Wong, Hang Dong, Xu Liang, Li-Ping Bai, Zhi-Hong Jiang, Yue Guo, Ah-Ng Tony Kong, Rui Wang, Richard Kin Ting Kam, Betty Yuen Kwan Law, Wendy Wen Luen Hsiao, Ka Man Chan, Jingrong Wang, Rick Wai Kit Chan, Jianru Guo, Wei Zhang, Feng Gen Yen, Hua Zhou, Elaine Lai Han Leung, Zhiling Yu,  and Liang Liu
9907-9924
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Human plasma metabolomics for identifying differential metabolites and predicting molecular subtypes of breast cancer

Human plasma metabolomics for identifying differential metabolites and predicting molecular subtypes of breast cancer

DOI: 10.18632/oncotarget.7155

Yong Fan, Xin Zhou, Tian-Song Xia, Zhuo Chen, Jin Li, Qun Liu, Raphael N. Alolga, Yan Chen, Mao-De Lai, Ping Li, Wei Zhu,  and Lian-Wen Qi
9925-9938
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Overexpression of TRIM14 promotes tongue squamous cell carcinoma aggressiveness by activating the NF-κB signaling pathway

Overexpression of TRIM14 promotes tongue squamous cell carcinoma aggressiveness by activating the NF-κB signaling pathway

DOI: 10.18632/oncotarget.6941

Xuan Su, Jianning Wang, Weichao Chen, Zhaoqu Li, Xiaoyan Fu,  and Ankui Yang
9939-9950
Abstract  |    |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Tumor suppressor microRNAs are downregulated in myelodysplastic syndrome with spliceosome mutations

Tumor suppressor microRNAs are downregulated in myelodysplastic syndrome with spliceosome mutations

DOI: 10.18632/oncotarget.7127

Derya Aslan, Christian Garde, Mette Katrine Nygaard, Alexandra Søgaard Helbo, Konstantinos Dimopoulos, Jakob Werner Hansen, Marianne Tang Severinsen, Marianne Bach Treppendahl, Lene Dissing Sjø, Kirsten Grønbæk,  and Lasse Sommer Kristensen
9951-9963
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

FYN expression potentiates FLT3-ITD induced STAT5 signaling in acute myeloid leukemia

FYN expression potentiates FLT3-ITD induced STAT5 signaling in acute myeloid leukemia

DOI: 10.18632/oncotarget.7128

Rohit A. Chougule, Julhash U. Kazi,  and Lars Rönnstrand
9964-9974
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Identification of drugs that restore primary cilium expression in cancer cells

Identification of drugs that restore primary cilium expression in cancer cells

DOI: 10.18632/oncotarget.7198

Niamat Ali Khan, Nicolas Willemarck, Ali Talebi, Arnaud Marchand, Maria Mercedes Binda, Jonas Dehairs, Natalia Rueda-Rincon, Veerle W. Daniels, Muralidhararao Bagadi, Deepak Balaji Thimiri Govinda Raj, Frank Vanderhoydonc, Sebastian Munck, Patrick Chaltin,  and Johannes V. Swinnen
9975-9992
Abstract  |   PDF  |  HTML  |  Order a Reprint

WISP-1 promotes VEGF-C-dependent lymphangiogenesis by inhibiting miR-300 in human oral squamous cell carcinoma cells

WISP-1 promotes VEGF-C-dependent lymphangiogenesis by inhibiting miR-300 in human oral squamous cell carcinoma cells

DOI: 10.18632/oncotarget.7014

Ching-Chia Lin, Po-Chun Chen, Ming-Yu Lein, Ching-Wen Tsao, Chiu-Chen Huang, Shih-Wei Wang, Chih-Hsin Tang,  and Kwong-Chung Tung
9993-10005
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Identifying molecular genetic features and oncogenic pathways of clear cell renal cell carcinoma through the anatomical (PADUA) scoring system

Identifying molecular genetic features and oncogenic pathways of clear cell renal cell carcinoma through the anatomical (PADUA) scoring system

DOI: 10.18632/oncotarget.7129

Hui Zhu, Haoyan Chen, Zhiqian Lin, Guohai Shi, Xiaozhu Lin, Zhiyuan Wu, Xia Zhang,  and Xi Zhang
10006-10014
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

ACTP: A webserver for predicting potential targets and relevant pathways of autophagy-modulating compounds

ACTP: A webserver for predicting potential targets and relevant pathways of autophagy-modulating compounds

DOI: 10.18632/oncotarget.7015

Tao Xie, Lan Zhang, Shouyue Zhang, Liang Ouyang, Haoyang Cai,  and Bo Liu
10015-10022
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

CD133 expression may be useful as a prognostic indicator in colorectal cancer, a tool for optimizing therapy and supportive evidence for the cancer stem cell hypothesis: a meta-analysis

CD133 expression may be useful as a prognostic indicator in colorectal cancer, a tool for optimizing therapy and supportive evidence for the cancer stem cell hypothesis: a meta-analysis

DOI: 10.18632/oncotarget.7054

Yang Zhao, Jing Peng, Enlong Zhang, Ning Jiang, Jiang Li, Qi Zhang, Xuening Zhang,  and Yuanjie Niu
10023-10036
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Cullin 4A (CUL4A), a direct target of miR-9 and miR-137, promotes gastric cancer proliferation and invasion by regulating the Hippo signaling pathway

Cullin 4A (CUL4A), a direct target of miR-9 and miR-137, promotes gastric cancer proliferation and invasion by regulating the Hippo signaling pathway

DOI: 10.18632/oncotarget.7048

Jun Deng, Wan Lei, Xiaojun Xiang, Ling Zhang, Jun Lei, Yu Gong, Meijiao Song, Yi Wang, Ziling Fang, Feng Yu, Miao Feng, Ze Sun, Jun Chen, Zhengyu Zhan,  and Jianping Xiong
10037-10050
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Pan-cancer analysis of intratumor heterogeneity as a prognostic determinant of survival

Pan-cancer analysis of intratumor heterogeneity as a prognostic determinant of survival

DOI: 10.18632/oncotarget.7067

Luc G.T. Morris, Nadeem Riaz, Alexis Desrichard, Yasin Şenbabaoğlu, A. Ari Hakimi, Vladimir Makarov, Jorge S. Reis-Filho,  and Timothy A. Chan
10051-10063
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Oncogenic K-ras confers SAHA resistance by up-regulating HDAC6 and c-myc expression

Oncogenic K-ras confers SAHA resistance by up-regulating HDAC6 and c-myc expression

DOI: 10.18632/oncotarget.7134

Qun Wang, Rong Tan, Xin Zhu, Yi Zhang, Zhiping Tan, Bing Su,  and Yu Li
10064-10072
Abstract  |   PDF  |  HTML  |  Order a Reprint

eIF4B is a convergent target and critical effector of oncogenic Pim and PI3K/Akt/mTOR signaling pathways in Abl transformants

eIF4B is a convergent target and critical effector of oncogenic Pim and PI3K/Akt/mTOR signaling pathways in Abl transformants

DOI: 10.18632/oncotarget.7164

Ke Chen, Jianling Yang, Jianning Li, Xuefei Wang, Yuhai Chen, Shile Huang,  and Ji-Long Chen
10073-10089
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

CD93 and dystroglycan cooperation in human endothelial cell adhesion and migration

CD93 and dystroglycan cooperation in human endothelial cell adhesion and migration

DOI: 10.18632/oncotarget.7136

Federico Galvagni, Federica Nardi, Marco Maida, Giulia Bernardini, Silvia Vannuccini, Felice Petraglia, Annalisa Santucci,  and Maurizio Orlandini
10090-10103
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The hormone response element mimic sequence of GAS5 lncRNA is sufficient to induce apoptosis in breast cancer cells

The hormone response element mimic sequence of GAS5 lncRNA is sufficient to induce apoptosis in breast cancer cells

DOI: 10.18632/oncotarget.7173

Mark R. Pickard,  and Gwyn T. Williams
10104-10116
Abstract  |   PDF  |  HTML  |  Order a Reprint

SERPINB1 expression is predictive for sensitivity and outcome of cisplatin-based chemotherapy in melanoma

SERPINB1 expression is predictive for sensitivity and outcome of cisplatin-based chemotherapy in melanoma

DOI: 10.18632/oncotarget.6956

Christoph Willmes, Rajiv Kumar, Jürgen C. Becker, Isabella Fried, P. Sivaramakrishna Rachakonda, Lidia M. Poppe, Sonja Hesbacher, Dirk Schadendorf, Antje Sucker, David Schrama,  and Selma Ugurel
10117-10132
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A function-blocking CD47 antibody suppresses stem cell and EGF signaling in triple-negative breast cancer

A function-blocking CD47 antibody suppresses stem cell and EGF signaling in triple-negative breast cancer

DOI: 10.18632/oncotarget.7100

Sukhbir Kaur, Abdel G. Elkahloun, Satya P. Singh, Qing-Rong Chen, Daoud M. Meerzaman, Timothy Song, Nidhi Manu, Weiwei Wu, Poonam Mannan, Susan H. Garfield,  and David D. Roberts
10133-10152
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Screening the yeast genome for energetic metabolism pathways involved in a phenotypic response to the anti-cancer agent 3-bromopyruvate

Screening the yeast genome for energetic metabolism pathways involved in a phenotypic response to the anti-cancer agent 3-bromopyruvate

DOI: 10.18632/oncotarget.7174

Paweł Lis, Paweł Jurkiewicz, Magdalena Cal-Bąkowska, Young H. Ko, Peter L. Pedersen, Andre Goffeau,  and Stanisław Ułaszewski
10153-10173
Abstract  |    |  PDF  |  HTML  |  Order a Reprint

Blastic plasmacytoid dendritic cell neoplasm frequently shows occult central nervous system involvement at diagnosis and benefits from intrathecal therapy

Blastic plasmacytoid dendritic cell neoplasm frequently shows occult central nervous system involvement at diagnosis and benefits from intrathecal therapy

DOI: 10.18632/oncotarget.7101

Lourdes Martín-Martín, Julia Almeida, Helena Pomares, Eva González-Barca, Pilar Bravo, Teresa Giménez, Cecilia Heras, José-Antonio Queizán, Elena Pérez-Ceballos, Violeta Martínez, Natalia Alonso, Carlota Calvo, Rodolfo Álvarez, María Dolores Caballero,  and Alberto Orfao
10174-10181
Abstract  |   PDF  |  HTML  |  Order a Reprint

Chromothripsis-like chromosomal rearrangements induced by ionizing radiation using proton microbeam irradiation system

Chromothripsis-like chromosomal rearrangements induced by ionizing radiation using proton microbeam irradiation system

DOI: 10.18632/oncotarget.7186

Maki Morishita, Tomoki Muramatsu, Yumiko Suto, Momoki Hirai, Teruaki Konishi, Shin Hayashi, Daichi Shigemizu, Tatsuhiko Tsunoda, Keiji Moriyama,  and Johji Inazawa
10182-10192
Abstract  |    |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Prognostic role of serum concentrations of high-sensitivity C-reactive protein in patients with metastatic colorectal cancer: results from the ITACa trial

Prognostic role of serum concentrations of high-sensitivity C-reactive protein in patients with metastatic colorectal cancer: results from the ITACa trial

DOI: 10.18632/oncotarget.7166

Andrea Casadei Gardini, Silvia Carloni, Emanuela Scarpi, Paolo Maltoni, Romolo M. Dorizzi, Alessandro Passardi, Giovanni Luca Frassineti, Pietro Cortesi, Maria Benedetta Giannini, Giorgia Marisi, Dino Amadori,  and Alessandro Lucchesi
10193-10202
Abstract  |   PDF  |  HTML  |  Order a Reprint

Bisleuconothine A, a bisindole alkaloid, inhibits colorectal cancer cell in vitro and in vivo targeting Wnt signaling

Bisleuconothine A, a bisindole alkaloid, inhibits colorectal cancer cell in vitro and in vivo targeting Wnt signaling

DOI: 10.18632/oncotarget.7190

Ling-Mei Kong, Tao Feng, Yuan-Yuan Wang, Xing-Yao Li, Zhen-Nan Ye, Tao An, Chen Qing, Xiao-Dong Luo,  and Yan Li
10203-10214
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A humanized antibody for imaging immune checkpoint ligand PD-L1 expression in tumors

A humanized antibody for imaging immune checkpoint ligand PD-L1 expression in tumors

DOI: 10.18632/oncotarget.7143

Samit Chatterjee, Wojciech G. Lesniak, Matthew Gabrielson, Ala Lisok, Bryan Wharram, Polina Sysa-Shah, Babak Behnam Azad, Martin G. Pomper,  and Sridhar Nimmagadda
10215-10227
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

NMU signaling promotes endometrial cancer cell progression by modulating adhesion signaling

NMU signaling promotes endometrial cancer cell progression by modulating adhesion signaling

DOI: 10.18632/oncotarget.7169

Ting-Yu Lin, Fang-Ju Wu, Chia-Lin Chang, Zhongyou Li,  and Ching-Wei Luo
10228-10242
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

ADAM10-mediated release of heregulin confers resistance to trastuzumab by activating HER3

ADAM10-mediated release of heregulin confers resistance to trastuzumab by activating HER3

DOI: 10.18632/oncotarget.7200

Eva A. Ebbing, Jan Paul Medema, Helene Damhofer, Sybren L. Meijer, Kausilia K. Krishnadath, Mark I. van Berge Henegouwen, Maarten F. Bijlsma,  and Hanneke W. M. van Laarhoven
10243-10254
Abstract  |    |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Invasive mouse gastric adenocarcinomas arising from Lgr5+ stem cells are dependent on crosstalk between the Hedgehog/GLI2 and mTOR pathways

Invasive mouse gastric adenocarcinomas arising from Lgr5+ stem cells are dependent on crosstalk between the Hedgehog/GLI2 and mTOR pathways

DOI: 10.18632/oncotarget.7182

Li-Jyun Syu, Xinyi Zhao, Yaqing Zhang, Marina Grachtchouk, Elise Demitrack, Alexandre Ermilov, Dawn M. Wilbert, Xinlei Zheng, Ashley Kaatz, Joel K. Greenson, Deborah L. Gumucio, Juanita L. Merchant, Marina Pasca di Magliano, Linda C. Samuelson,  and Andrzej A. Dlugosz
10255-10270
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Phenylethyl isothiocyanate reverses cisplatin resistance in biliary tract cancer cells via glutathionylation-dependent degradation of Mcl-1

Phenylethyl isothiocyanate reverses cisplatin resistance in biliary tract cancer cells via glutathionylation-dependent degradation of Mcl-1

DOI: 10.18632/oncotarget.7171

Qiwei Li, Ming Zhan, Wei Chen, Benpeng Zhao, Kai Yang, Jie Yang, Jing Yi, Qihong Huang, Man Mohan, Zhaoyuan Hou,  and Jian Wang
10271-10282
Abstract  |   PDF  |  HTML  |  Order a Reprint

Ras-activated RSK1 phosphorylates EBP50 to regulate its nuclear localization and promote cell proliferation

Ras-activated RSK1 phosphorylates EBP50 to regulate its nuclear localization and promote cell proliferation

DOI: 10.18632/oncotarget.7184

HooiCheng Lim,  and Tzuu-Shuh Jou
10283-10296
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

miR-217 and CAGE form feedback loop and regulates the response to anti-cancer drugs through EGFR and HER2

miR-217 and CAGE form feedback loop and regulates the response to anti-cancer drugs through EGFR and HER2

DOI: 10.18632/oncotarget.7185

Youngmi Kim, Hyuna Kim, Deokbum Park, Minho Han, Hansoo Lee, Yun Sil Lee, Jongseon Choe, Young Myeong Kim,  and Dooil Jeoung
10297-10321
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Aberrant gene methylation in non-neoplastic mucosa as a predictive marker of ulcerative colitis-associated CRC

Aberrant gene methylation in non-neoplastic mucosa as a predictive marker of ulcerative colitis-associated CRC

DOI: 10.18632/oncotarget.7188

Marco Scarpa, Melania Scarpa, Ignazio Castagliuolo, Francesca Erroi, Andromachi Kotsafti, Silvia Basato, Paola Brun, Renata D’Incà, Massimo Rugge, Imerio Angriman,  and Carlo Castoro
10322-10331
Abstract  |   PDF  |  HTML  |  Order a Reprint

Implication of combined PD-L1/PD-1 blockade with cytokine-induced killer cells as a synergistic immunotherapy for gastrointestinal cancer

Implication of combined PD-L1/PD-1 blockade with cytokine-induced killer cells as a synergistic immunotherapy for gastrointestinal cancer

DOI: 10.18632/oncotarget.7243

Congqi Dai, Fengjuan Lin, Ruixuan Geng, Xiaoxiao Ge, Wenbo Tang, Jinjia Chang, Zheng Wu, Xinyang Liu, Ying Lin, Zhe Zhang,  and Jin Li
10332-10344
Abstract  |    |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Lovastatin lactone elicits human lung cancer cell apoptosis via a COX-2/PPARγ-dependent pathway

Lovastatin lactone elicits human lung cancer cell apoptosis via a COX-2/PPARγ-dependent pathway

DOI: 10.18632/oncotarget.7213

Udo Walther, Kristin Emmrich, Robert Ramer, Nadine Mittag,  and Burkhard Hinz
10345-10362
Abstract  |   PDF  |  HTML  |  Order a Reprint

Mechanism of progestin resistance in endometrial precancer/cancer through Nrf2-AKR1C1 pathway

Mechanism of progestin resistance in endometrial precancer/cancer through Nrf2-AKR1C1 pathway

DOI: 10.18632/oncotarget.7004

Yiying Wang, Yue Wang, Zhenbo Zhang, Ji-Young Park, Donghui Guo, Hong Liao, Xiaofang Yi, Yu Zheng, Donna Zhang, Setsuko K. Chambers,  and Wenxin Zheng
10363-10372
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Estrogen receptor beta as a prognostic factor in breast cancer patients: A systematic review and meta-analysis

Estrogen receptor beta as a prognostic factor in breast cancer patients: A systematic review and meta-analysis

DOI: 10.18632/oncotarget.7219

Weige Tan, Qian Li, Kai Chen, Fengxi Su, Erwei Song,  and Chang Gong
10373-10385
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Resistance to the nucleotide analogue cidofovir in HPV(+) cells: a multifactorial process involving UMP/CMP kinase 1

Resistance to the nucleotide analogue cidofovir in HPV(+) cells: a multifactorial process involving UMP/CMP kinase 1

DOI: 10.18632/oncotarget.7006

Dimitri Topalis, Tatiane C. Nogueira, Tim De Schutter, Chahrazade El Amri, Marcela Krečmerová, Lieve Naesens, Jan Balzarini, Graciela Andrei,  and Robert Snoeck
10386-10401
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

OLA1 contributes to epithelial-mesenchymal transition in lung cancer by modulating the GSK3β/snail/E-cadherin signaling

OLA1 contributes to epithelial-mesenchymal transition in lung cancer by modulating the GSK3β/snail/E-cadherin signaling

DOI: 10.18632/oncotarget.7224

Li Bai, Zubin Yu, Jiawei Zhang, Shuai Yuan, Chen Liao, Prince V.S. Jeyabal, Valentina Rubio, Huarong Chen, Yafei Li,  and Zheng-Zheng Shi
10402-10413
Abstract  |   PDF  |  HTML  |  Order a Reprint

MicroRNA-34a promotes genomic instability by a broad suppression of genome maintenance mechanisms downstream of the oncogene KSHV-vGPCR

MicroRNA-34a promotes genomic instability by a broad suppression of genome maintenance mechanisms downstream of the oncogene KSHV-vGPCR

DOI: 10.18632/oncotarget.7248

Claudia J. Krause, Oliver Popp, Nanthakumar Thirunarayanan, Gunnar Dittmar, Martin Lipp,  and Gerd Müller
10414-10432
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Perlecan/HSPG2 and matrilysin/MMP-7 as indices of tissue invasion: tissue localization and circulating perlecan fragments in a cohort of 288 radical prostatectomy patients

Perlecan/HSPG2 and matrilysin/MMP-7 as indices of tissue invasion: tissue localization and circulating perlecan fragments in a cohort of 288 radical prostatectomy patients

DOI: 10.18632/oncotarget.7197

Brian Grindel, Quanlin Li, Rebecca Arnold, John Petros, Majd Zayzafoon, Mark Muldoon, James Stave, Leland W. K. Chung,  and Mary C. Farach-Carson
10433-10447
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Sodium alginate prevents progression of non-alcoholic steatohepatitis and liver carcinogenesis in obese and diabetic mice

Sodium alginate prevents progression of non-alcoholic steatohepatitis and liver carcinogenesis in obese and diabetic mice

DOI: 10.18632/oncotarget.7249

Tsuneyuki Miyazaki, Yohei Shirakami, Masaya Kubota, Takayasu Ideta, Takahiro Kochi, Hiroyasu Sakai, Takuji Tanaka, Hisataka Moriwaki,  and Masahito Shimizu
10448-10458
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Role of heme oxygenase-1 in the pathogenesis and tumorigenicity of Kaposi’s sarcoma-associated herpesvirus

Role of heme oxygenase-1 in the pathogenesis and tumorigenicity of Kaposi’s sarcoma-associated herpesvirus

DOI: 10.18632/oncotarget.7227

Lu Dai, Jing Qiao, David Nguyen, Amanda P. Struckhoff, Lisa Doyle, Karlie Bonstaff, Luis Del Valle, Chris Parsons, Bryan P. Toole, Rolf Renne,  and Zhiqiang Qin
10459-10471
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The sonic hedgehog signaling pathway stimulates anaplastic thyroid cancer cell motility and invasiveness by activating Akt and c-Met

The sonic hedgehog signaling pathway stimulates anaplastic thyroid cancer cell motility and invasiveness by activating Akt and c-Met

DOI: 10.18632/oncotarget.7228

Ashley J. Williamson, Michelle E. Doscas, Jin Ye, Katherine B. Heiden, Mingzhao Xing, Yi Li, Richard A. Prinz,  and Xiulong Xu
10472-10485
Abstract  |   PDF  |  HTML  |  Order a Reprint

Lipid tethering of breast tumor cells enables real-time imaging of free-floating cell dynamics and drug response

Lipid tethering of breast tumor cells enables real-time imaging of free-floating cell dynamics and drug response

DOI: 10.18632/oncotarget.7251

Kristi R. Chakrabarti, James I. Andorko, Rebecca A. Whipple, Peipei Zhang, Elisabeth L. Sooklal, Stuart S. Martin,  and Christopher M. Jewell
10486-10497
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Diallyl disulfide suppresses epithelial-mesenchymal transition, invasion and proliferation by downregulation of LIMK1 in gastric cancer

Diallyl disulfide suppresses epithelial-mesenchymal transition, invasion and proliferation by downregulation of LIMK1 in gastric cancer

DOI: 10.18632/oncotarget.7252

Bo Su, Jian Su, Ying Zeng, Fang Liu, Hong Xia, Yan-hua Ma, Zhi-gang Zhou, Shuo Zhang, Bang-min Yang, You-Hua Wu, Xi Zeng, Xiao- Hong Ai, Hui Ling, Hao Jiang,  and Qi Su
10498-10512
Abstract  |    |  PDF  |  HTML  |  Order a Reprint

Meta-analysis of the differentially expressed microRNA profiles in nasopharyngeal carcinoma

Meta-analysis of the differentially expressed microRNA profiles in nasopharyngeal carcinoma

DOI: 10.18632/oncotarget.7013

Junwen Luan, Junfu Wang, Qinghong Su, Xuemei Chen, Guosheng Jiang,  and Xiaoqun Xu
10513-10521
Abstract  |   PDF  |  HTML  |  Order a Reprint

Marked enhancement of lysosomal targeting and efficacy of ErbB2-targeted drug delivery by HSP90 inhibition

Marked enhancement of lysosomal targeting and efficacy of ErbB2-targeted drug delivery by HSP90 inhibition

DOI: 10.18632/oncotarget.7231

Srikumar M. Raja, Swapnil S. Desale, Bhopal Mohapatra, Haitao Luan, Kruti Soni, Jinjin Zhang, Matthew A. Storck, Dan Feng, Timothy A. Bielecki, Vimla Band, Samuel M. Cohen, Tatiana K. Bronich,  and Hamid Band
10522-10535
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Quantification of Unmethylated Alu (QUAlu): a tool to assess global hypomethylation in routine clinical samples

Quantification of Unmethylated Alu (QUAlu): a tool to assess global hypomethylation in routine clinical samples

DOI: 10.18632/oncotarget.7233

Raquel Buj, Izaskun Mallona, Anna Díez-Villanueva, Víctor Barrera, Dídac Mauricio, Manel Puig-Domingo, Jordi L. Reverter, Xavier Matias-Guiu, Daniel Azuara, Jose L. Ramírez, Sergio Alonso, Rafael Rosell, Gabriel Capellà, Manuel Perucho, Mercedes Robledo, Miguel A. Peinado,  and Mireia Jordà
10536-10546
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Next-generation sequencing reveals somatic mutations that confer exceptional response to everolimus

Next-generation sequencing reveals somatic mutations that confer exceptional response to everolimus

DOI: 10.18632/oncotarget.7234

Sun Min Lim, Hyung Soon Park, Sangwoo Kim, Sora Kim, Siraj M. Ali, Joel R. Greenbowe, In Seok Yang, Nak-Jung Kwon, Jae Lyun Lee, Min-Hee Ryu, Jin-Hee Ahn, Jeeyun Lee, Min Goo Lee, Hyo Song Kim, Hyunki Kim, Hye Ryun Kim, Yong Wha Moon, Hyun Cheol Chung, Joo-Hang Kim, Yoon-Koo Kang,  and Byoung Chul Cho
10547-10556
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Activation of the PD-1/PD-L1 immune checkpoint confers tumor cell chemoresistance associated with increased metastasis

Activation of the PD-1/PD-L1 immune checkpoint confers tumor cell chemoresistance associated with increased metastasis

DOI: 10.18632/oncotarget.7235

Madison Black, Ivraym B. Barsoum, Peter Truesdell, Tiziana Cotechini, Shannyn K. Macdonald-Goodfellow, Margaret Petroff, D. Robert Siemens, Madhuri Koti, Andrew W.B. Craig,  and Charles H. Graham
10557-10567
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The status of epidermal growth factor receptor in borderline ovarian tumours

The status of epidermal growth factor receptor in borderline ovarian tumours

DOI: 10.18632/oncotarget.7257

Rania Showeil, Claudia Romano, Mikel Valganon, Maryou Lambros, Pritesh Trivedi, Susan Van Noorden, Ruethairat Sriraksa, Dalal El-Kaffash, Nour El-Etreby, Rachael Natrajan, Letizia Foroni, Richard Osborne,  and Mona El-Bahrawy
10568-10577
Abstract  |   PDF  |  HTML  |  Order a Reprint

Heterogenous ribonucleoprotein A18 (hnRNP A18) promotes tumor growth by increasing protein translation of selected transcripts in cancer cells

Heterogenous ribonucleoprotein A18 (hnRNP A18) promotes tumor growth by increasing protein translation of selected transcripts in cancer cells

DOI: 10.18632/oncotarget.7020

Elizabeth T. Chang, Palak R. Parekh, Qingyuan Yang, Duc M. Nguyen,  and France Carrier
10578-10593
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Estrogen receptor-mediated miR-486-5p regulation of OLFM4 expression in ovarian cancer

Estrogen receptor-mediated miR-486-5p regulation of OLFM4 expression in ovarian cancer

DOI: 10.18632/oncotarget.7236

Hanyu Ma, Tian Tian, Shuang Liang, Xubin Liu, Hongwei Shen, Meng Xia, Xingyang Liu, Wenhui Zhang, Liantang Wang, Shangwu Chen,  and Li Yu
10594-10605
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Neonatal bisphenol A exposure induces meiotic arrest and apoptosis of spermatogenic cells

Neonatal bisphenol A exposure induces meiotic arrest and apoptosis of spermatogenic cells

DOI: 10.18632/oncotarget.7218

Meina Xie, Pengli Bu, Fengjie Li, Shijian Lan, Hongjuan Wu, Lu Yuan,  and Ying Wang
10606-10615
Abstract  |   PDF  |  HTML  |  Order a Reprint

Aminomethylphosphonic acid inhibits growth and metastasis of human prostate cancer in an orthotopic xenograft mouse model

Aminomethylphosphonic acid inhibits growth and metastasis of human prostate cancer in an orthotopic xenograft mouse model

DOI: 10.18632/oncotarget.7055

Keshab Raj Parajuli, Qiuyang Zhang, Sen Liu,  and Zongbing You
10616-10626
Abstract  |   PDF  |  HTML  |  Order a Reprint

PHOX2B is a suppressor of neuroblastoma metastasis

PHOX2B is a suppressor of neuroblastoma metastasis

DOI: 10.18632/oncotarget.7056

Osnat Naftali, Shelly Maman, Tsipi Meshel, Orit Sagi-Assif, Ravit Ginat,  and Isaac P. Witz
10627-10637
Abstract  |   PDF  |  HTML  |  Order a Reprint

Construction of a new anti-CD19 chimeric antigen receptor and the anti-leukemia function study of the transduced T cells

Construction of a new anti-CD19 chimeric antigen receptor and the anti-leukemia function study of the transduced T cells

DOI: 10.18632/oncotarget.7079

Na An, Zhongfei Tao, Saisai Li, Haiyan Xing, Kejing Tang, Zheng Tian, Qing Rao, Min Wang,  and Jianxiang Wang
10638-10649
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The expression of presenilin 1 enhances carcinogenesis and metastasis in gastric cancer

The expression of presenilin 1 enhances carcinogenesis and metastasis in gastric cancer

DOI: 10.18632/oncotarget.7298

Ping Li, Xi Lin, Jun-Rong Zhang, Yun Li, Jun Lu, Fei-Chao Huang, Chao-Hui Zheng, Jian-Wei Xie, Jia-Bin Wang,  and Chang-Ming Huang
10650-10662
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Clinical Research Papers

MicroRNA-223 and microRNA-92a in stool and plasma samples act as complementary biomarkers to increase colorectal cancer detection

MicroRNA-223 and microRNA-92a in stool and plasma samples act as complementary biomarkers to increase colorectal cancer detection

DOI: 10.18632/oncotarget.7119

Pi-Yueh Chang, Chia-Chun Chen, Yu-Sun Chang, Wen-Sy Tsai, Jeng-Fu You, Geng-Ping Lin, Ting-Wen Chen, Jinn-Shiun Chen,  and Err-Cheng Chan
10663-10675
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Histology-based prediction of lymph node metastases in early gastric cancer as decision guidance for endoscopic resection

Histology-based prediction of lymph node metastases in early gastric cancer as decision guidance for endoscopic resection

DOI: 10.18632/oncotarget.7221

Ulrich Ronellenfitsch, Christiane Lippert, Rainer Grobholz, Siegfried Lang, Stefan Post, Georg Kähler,  and Timo Gaiser
10676-10683
Abstract  |   PDF  |  HTML  |  Order a Reprint

Effect of postoperative radiotherapy for squamous cell cancer of the breast in a surveillance epidemiology and end results population-based study

Effect of postoperative radiotherapy for squamous cell cancer of the breast in a surveillance epidemiology and end results population-based study

DOI: 10.18632/oncotarget.7222

San-Gang Wu, Jia-Yuan Sun, Wen-Ming Liu, Feng-Yan Li, Huan-Xin Lin,  and Zhen-Yu He
10684-10693
Abstract  |   PDF  |  HTML  |  Order a Reprint


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