Oncotarget

Vol 7, No 7

February 16, 2016

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Spatially- and temporally-controlled postnatal p53 knockdown cooperates with embryonic Schwann cell precursor Nf1 gene loss to promote malignant peripheral nerve sheath tumor formation. See Hirbe et al.

Table of Contents

Editorial

MTHFD2- a new twist?

MTHFD2- a new twist?

https://doi.org/10.18632/oncotarget.7147

Philip M. Tedeschi, Kathleen W. Scotto, John Kerrigan,  and Joseph R. Bertino
7368-7369
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Editorial: Chromosome

Understanding genome structural variations

Understanding genome structural variations

https://doi.org/10.18632/oncotarget.6485

Alexej Abyzov, Shantao Li,  and Mark B. Gerstein
7370-7371
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Priority Research Papers

Antimetabolite TTL-315 selectively kills glucose-deprived cancer cells and enhances responses to cytotoxic chemotherapy in preclinical models of cancer

Antimetabolite TTL-315 selectively kills glucose-deprived cancer cells and enhances responses to cytotoxic chemotherapy in preclinical models of cancer

https://doi.org/10.18632/oncotarget.7058

James DuHadaway,  and George C. Prendergast
7372-7380
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A targeted genetic association study of epithelial ovarian cancer susceptibility

A targeted genetic association study of epithelial ovarian cancer susceptibility

https://doi.org/10.18632/oncotarget.7121

Madalene Earp, Stacey J. Winham, Nicholas Larson, Jennifer B. Permuth, Hugues Sicotte, Jeremy Chien, Hoda Anton-Culver, Elisa V. Bandera, Andrew Berchuck, Linda S. Cook, Daniel Cramer, Jennifer A. Doherty, Marc T. Goodman, Douglas A. Levine, Alvaro N.A. Monteiro, Roberta B. Ness, Celeste L. Pearce, Mary Anne Rossing, Shelley S. Tworoger, Nicolas Wentzensen, Maria Bisogna, Louise Brinton, Angela Brooks-Wilson, Michael E. Carney, Julie M. Cunningham, Robert P. Edwards, Zachary C. Fogarty, Edwin S. Iversen, Peter Kraft, Melissa C. Larson, Nhu D. Le, Hui-Yi Lin, Jolanta Lissowska, Francesmary Modugno, Kirsten B. Moysich, Sara H. Olson, Malcolm C. Pike, Elizabeth M. Poole, David N. Rider, Kathryn L. Terry, Pamela J. Thompson, David van den Berg, Robert A. Vierkant, Allison F. Vitonis, Lynne R. Wilkens, Anna H. Wu, Hannah P. Yang, Argyrios Ziogas, Catherine M. Phelan, Joellen M. Schildkraut, Yian Ann Chen, Thomas A. Sellers, Brooke L. Fridley,  and Ellen L. Goode
7381-7389
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Inhibitors of histone deacetylase 1 reverse the immune evasion phenotype to enhance T-cell mediated lysis of prostate and breast carcinoma cells

Inhibitors of histone deacetylase 1 reverse the immune evasion phenotype to enhance T-cell mediated lysis of prostate and breast carcinoma cells

https://doi.org/10.18632/oncotarget.7180

Sofia R. Gameiro, Anthony S. Malamas, Kwong Y. Tsang, Soldano Ferrone,  and James W. Hodge
7390-7402
Abstract  |  PDF  |  HTML  |  Order a Reprint

Spatially- and temporally-controlled postnatal p53 knockdown cooperates with embryonic Schwann cell precursor Nf1 gene loss to promote malignant peripheral nerve sheath tumor formation

Spatially- and temporally-controlled postnatal p53 knockdown cooperates with embryonic Schwann cell precursor Nf1 gene loss to promote malignant peripheral nerve sheath tumor formation

https://doi.org/10.18632/oncotarget.7232

Angela C. Hirbe, Sonika Dahiya, Dinorah Friedmann-Morvinski, Inder M. Verma, D. Wade Clapp,  and David H. Gutmann
7403-7414
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Systematic drug perturbations on cancer cells reveal diverse exit paths from proliferative state

Systematic drug perturbations on cancer cells reveal diverse exit paths from proliferative state

https://doi.org/10.18632/oncotarget.7294

Joseph X. Zhou, Zerrin Isik, Caide Xiao, Irit Rubin, Stuart A. Kauffman, Michael Schroeder,  and Sui Huang
7415-7425
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Research Papers: Gerotarget (Focus on Aging)

Epigallocatechin-3-gallate induces oxidative phosphorylation by activating cytochrome c oxidase in human cultured neurons and astrocytes

Epigallocatechin-3-gallate induces oxidative phosphorylation by activating cytochrome c oxidase in human cultured neurons and astrocytes

https://doi.org/10.18632/oncotarget.6863

Gloria Castellano-González, Nicolas Pichaud, J. William O. Ballard, Alban Bessede, Helder Marcal,  and Gilles J. Guillemin
7426-7440
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Neuronal hemoglobin in mitochondria is reduced by forming a complex with α-synuclein in aging monkey brains

Neuronal hemoglobin in mitochondria is reduced by forming a complex with α-synuclein in aging monkey brains

https://doi.org/10.18632/oncotarget.7046

Weiwei Yang, Xuran Li, Xin Li, Xuying Li,  and Shun Yu
7441-7454
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Identification of novel plasma glycosylation-associated markers of aging

Identification of novel plasma glycosylation-associated markers of aging

https://doi.org/10.18632/oncotarget.7059

Mariangela Catera, Vincenzo Borelli, Nadia Malagolini, Mariella Chiricolo, Giulia Venturi, Celso A. Reis, Hugo Osorio, Provvidenza M. Abruzzo, Miriam Capri, Daniela Monti, Rita Ostan, Claudio Franceschi,  and Fabio Dall’Olio
7455-7468
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Selective brain penetrable Nurr1 transactivator for treating Parkinson’s disease

Selective brain penetrable Nurr1 transactivator for treating Parkinson’s disease

https://doi.org/10.18632/oncotarget.7191

Jun Wang, Weina Bi, Wei Zhao, Merina Varghese, Rick J. Koch, Ruth H. Walker, Roshantha A. Chandraratna, Martin E. Sanders, Amanda Janesick, Bruce Blumberg, Libby Ward, Lap Ho,  and Giulio M. Pasinetti
7469-7479
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Research Papers: Pathology

Epithelioid hemangioendotheliomas with TFE3 gene translocations are compossible with CAMTA1 gene rearrangements

Epithelioid hemangioendotheliomas with TFE3 gene translocations are compossible with CAMTA1 gene rearrangements

https://doi.org/10.18632/oncotarget.7060

Seok Joo Lee, Woo Ick Yang, Woo-Suk Chung,  and Sang Kyum Kim
7480-7488
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Thrombopoietin: a potential diagnostic indicator of immune thrombocytopenia in pregnancy

Thrombopoietin: a potential diagnostic indicator of immune thrombocytopenia in pregnancy

https://doi.org/10.18632/oncotarget.7106

Xu Zhang, Yajing Zhao, Xiaoqing Li, Panpan Han, Fangmiao Jing, Zhangyuan Kong, Hai Zhou, Jihua Qiu, Lizhen Li, Jun Peng,  and Ming Hou
7489-7496
Abstract  |  PDF  |  HTML  |  Order a Reprint

Modular transcriptional repertoire and MicroRNA target analyses characterize genomic dysregulation in the thymus of Down syndrome infants

Modular transcriptional repertoire and MicroRNA target analyses characterize genomic dysregulation in the thymus of Down syndrome infants

https://doi.org/10.18632/oncotarget.7120

Carlos Alberto Moreira-Filho, Silvia Yumi Bando, Fernanda Bernardi Bertonha, Filipi Nascimento Silva, Luciano da Fontoura Costa, Leandro Rodrigues Ferreira, Glaucio Furlanetto, Paulo Chacur, Maria Claudia Nogueira Zerbini,  and Magda Carneiro-Sampaio
7497-7533
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Crosstalk between Ca2+ signaling and mitochondrial H2O2 is required for rotenone inhibition of mTOR signaling pathway leading to neuronal apoptosis

Crosstalk between Ca2+ signaling and mitochondrial H2O2 is required for rotenone inhibition of mTOR signaling pathway leading to neuronal apoptosis

https://doi.org/10.18632/oncotarget.7183

Chunxiao Liu, Yangjing Ye, Qian Zhou, Ruijie Zhang, Hai Zhang, Wen Liu, Chong Xu, Lei Liu, Shile Huang,  and Long Chen
7534-7549
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Research Papers: Immunology

Novel CXCL13 transgenic mouse: inflammation drives pathogenic effect of CXCL13 in experimental myasthenia gravis

Novel CXCL13 transgenic mouse: inflammation drives pathogenic effect of CXCL13 in experimental myasthenia gravis

https://doi.org/10.18632/oncotarget.6885

Julia Miriam Weiss, Marieke Robinet, Revital Aricha, Perrine Cufi, Bérengère Villeret, Frida Lantner, Idit Shachar, Sara Fuchs, Miriam C. Souroujon, Sonia Berrih-Aknin,  and Rozen Le Panse
7550-7562
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Successful expansion of functional and stable regulatory T cells for immunotherapy in liver transplantation

Successful expansion of functional and stable regulatory T cells for immunotherapy in liver transplantation

https://doi.org/10.18632/oncotarget.6927

Niloufar Safinia, Trishan Vaikunthanathan, Henrieta Fraser, Sarah Thirkell, Katie Lowe, Laura Blackmore, Gavin Whitehouse, Marc Martinez-Llordella, Wayel Jassem, Alberto Sanchez-Fueyo, Robert I. Lechler,  and Giovanna Lombardi
7563-7577
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Targeting Toll-like receptor 4 prevents cobalt-mediated inflammation

Targeting Toll-like receptor 4 prevents cobalt-mediated inflammation

https://doi.org/10.18632/oncotarget.7105

Helen Lawrence, Amy Elizabeth Mawdesley, James Patrick Holland, John Andrew Kirby, David John Deehan,  and Alison Jane Tyson-Capper
7578-7585
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Dynamics of cytotoxic T cell subsets during immunotherapy predicts outcome in acute myeloid leukemia

Dynamics of cytotoxic T cell subsets during immunotherapy predicts outcome in acute myeloid leukemia

https://doi.org/10.18632/oncotarget.7210

Frida Ewald Sander, Anna Rydström, Elin Bernson, Roberta Kiffin, Rebecca Riise, Johan Aurelius, Harald Anderson, Mats Brune, Robin Foà, Kristoffer Hellstrand, Fredrik B. Thorén,  and Anna Martner
7586-7596
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Reviews

90 Y-ibritumomab tiuxetan: a nearly forgotten opportunity

90 Y-ibritumomab tiuxetan: a nearly forgotten opportunity

https://doi.org/10.18632/oncotarget.6531

Patrizia Mondello, Salvatore Cuzzocrea, Michele Navarra,  and Michael Mian
7597-7609
Abstract  |  PDF  |  HTML  |  Order a Reprint

Targeting Notch to overcome radiation resistance

Targeting Notch to overcome radiation resistance

https://doi.org/10.18632/oncotarget.6714

Sanaz Yahyanejad, Jan Theys,  and Marc Vooijs
7610-7628
Abstract  |  PDF  |  HTML  |  Order a Reprint

Clinical Reviews

Effectiveness and safety of poly (ADP-ribose) polymerase inhibitors in cancer therapy: A systematic review and meta-analysis

Effectiveness and safety of poly (ADP-ribose) polymerase inhibitors in cancer therapy: A systematic review and meta-analysis

https://doi.org/10.18632/oncotarget.5367

Zhengqiang Bao, Chao Cao, Xinwei Geng, Baoping Tian, Yanping Wu, Chao Zhang, Zhihua Chen, Wen Li, Huahao Shen,  and Songmin Ying
7629-7639
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Research Papers

Proteomic discovery of MNT as a novel interacting partner of E3 ubiquitin ligase E6AP and a key mediator of myeloid differentiation

Proteomic discovery of MNT as a novel interacting partner of E3 ubiquitin ligase E6AP and a key mediator of myeloid differentiation

https://doi.org/10.18632/oncotarget.6156

Isha Kapoor, Jitendra Kanaujiya, Yogesh Kumar, Jagadeshwar Reddy Thota, Madan L.B. Bhatt, Naibedya Chattopadhyay, Sabyasachi Sanyal,  and Arun Kumar Trivedi
7640-7656
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Role of CD44high/CD133high HCT-116 cells in the tumorigenesis of colon cancer

Role of CD44high/CD133high HCT-116 cells in the tumorigenesis of colon cancer

https://doi.org/10.18632/oncotarget.7084

Jin-Yong Zhou, Min Chen, Long Ma, Xiaoxiao Wang, Yu-Gen Chen,  and Shen-Lin Liu
7657-7666
Abstract  |  PDF  |  HTML  |  Order a Reprint

Sonic hedgehog inhibitors prevent colitis-associated cancer via orchestrated mechanisms of IL-6/gp130 inhibition, 15-PGDH induction, Bcl-2 abrogation, and tumorsphere inhibition

Sonic hedgehog inhibitors prevent colitis-associated cancer via orchestrated mechanisms of IL-6/gp130 inhibition, 15-PGDH induction, Bcl-2 abrogation, and tumorsphere inhibition

https://doi.org/10.18632/oncotarget.6765

Napapan Kangwan, Yoon-Jae Kim, Young Min Han, Migyeong Jeong, Jong-Min Park, Eun-Jin Go,  and Ki-Baik Hahm
7667-7682
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

IGF-I induces upregulation of DDR1 collagen receptor in breast cancer cells by suppressing MIR-199a-5p through the PI3K/AKT pathway

IGF-I induces upregulation of DDR1 collagen receptor in breast cancer cells by suppressing MIR-199a-5p through the PI3K/AKT pathway

https://doi.org/10.18632/oncotarget.6524

Roberta Matà, Chiara Palladino, Maria Luisa Nicolosi, Anna Rita Lo Presti, Roberta Malaguarnera, Marco Ragusa, Daniela Sciortino, Andrea Morrione, Marcello Maggiolini, Veronica Vella,  and Antonino Belfiore
7683-7700
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Loss of CtIP disturbs homologous recombination repair and sensitizes breast cancer cells to PARP inhibitors

Loss of CtIP disturbs homologous recombination repair and sensitizes breast cancer cells to PARP inhibitors

https://doi.org/10.18632/oncotarget.6715

Junhui Wang, Qianshan Ding, Hiroaki Fujimori, Akira Motegi, Yoshio Miki,  and Mitsuko Masutani
7701-7714
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Valproic acid potentiates the anticancer activity of capecitabine in vitro and in vivo in breast cancer models via induction of thymidine phosphorylase expression

Valproic acid potentiates the anticancer activity of capecitabine in vitro and in vivo in breast cancer models via induction of thymidine phosphorylase expression

https://doi.org/10.18632/oncotarget.6802

Manuela Terranova-Barberio, Maria Serena Roca, Andrea Ilaria Zotti, Alessandra Leone, Francesca Bruzzese, Carlo Vitagliano, Giosuè Scogliamiglio, Domenico Russo, Giovanni D’Angelo, Renato Franco, Alfredo Budillon,  and Elena Di Gennaro
7715-7731
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Control of glioma cell migration and invasiveness by GDF-15

Control of glioma cell migration and invasiveness by GDF-15

https://doi.org/10.18632/oncotarget.6816

Paula Codó, Michael Weller, Kerstin Kaulich, Daniel Schraivogel, Manuela Silginer, Guido Reifenberger, Gunter Meister,  and Patrick Roth
7732-7746
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

HDAC3 mediates smoking-induced pancreatic cancer

HDAC3 mediates smoking-induced pancreatic cancer

https://doi.org/10.18632/oncotarget.6820

Mouad Edderkaoui, Shiping Xu, Chintan Chheda, Susan Morvaridi, Robert W. Hu, Paul J. Grippo, Emman Mascariñas, Daniel R. Principe, Beatrice Knudsen, Jing Xue, Aida Habtezion, Dale Uyeminami, Kent E. Pinkerton,  and Stephen J. Pandol
7747-7760
Abstract  |  PDF  |  HTML  |  Order a Reprint

Adenomatous polyposis coli genotype-dependent toll-like receptor 4 activity in colon cancer

Adenomatous polyposis coli genotype-dependent toll-like receptor 4 activity in colon cancer

https://doi.org/10.18632/oncotarget.6844

Feng Wen, Yongmei Liu, Wei Wang, Meng Li, Fuchun Guo, Yaxiong Sang, Qing Qin, Yongsheng Wang,  and Qiu Li
7761-7772
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Analysis of risk and predictors of brain radiation necrosis after radiosurgery

Analysis of risk and predictors of brain radiation necrosis after radiosurgery

https://doi.org/10.18632/oncotarget.6532

Hongqing Zhuang, Yi Zheng, Junjie Wang, Joe Y. Chang, Xiaoguang Wang, Zhiyong Yuan,  and Ping Wang
7773-7779
Abstract  |  PDF  |  HTML  |  Order a Reprint

Hepatitis B virus X protein binding to hepsin promotes C3 production by inducing IL-6 secretion from hepatocytes

Hepatitis B virus X protein binding to hepsin promotes C3 production by inducing IL-6 secretion from hepatocytes

https://doi.org/10.18632/oncotarget.6846

Mingming Zhang, Jianxin Gu,  and Chunyi Zhang
7780-7800
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

PHLPP negatively regulates cell motility through inhibition of Akt activity and integrin expression in pancreatic cancer cells

PHLPP negatively regulates cell motility through inhibition of Akt activity and integrin expression in pancreatic cancer cells

https://doi.org/10.18632/oncotarget.6848

Alena J. Smith, Yang-An Wen, Payton D. Stevens, Jingpeng Liu, Chi Wang,  and Tianyan Gao
7801-7815
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Hypoxia-inducible factor 1 upregulation of both VEGF and ANGPTL4 is required to promote the angiogenic phenotype in uveal melanoma

Hypoxia-inducible factor 1 upregulation of both VEGF and ANGPTL4 is required to promote the angiogenic phenotype in uveal melanoma

https://doi.org/10.18632/oncotarget.6868

Ke Hu, Savalan Babapoor-Farrokhran, Murilo Rodrigues, Monika Deshpande, Brooks Puchner, Fabiana Kashiwabuchi, Syed Junaid Hassan, Laura Asnaghi, James T. Handa, Shannath Merbs, Charles G. Eberhart, Gregg L. Semenza, Silvia Montaner,  and Akrit Sodhi
7816-7828
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Deletions of multidrug resistance gene loci in breast cancer leads to the down-regulation of its expression and predict tumor response to neoadjuvant chemotherapy

Deletions of multidrug resistance gene loci in breast cancer leads to the down-regulation of its expression and predict tumor response to neoadjuvant chemotherapy

https://doi.org/10.18632/oncotarget.6953

Nikolai V. Litviakov, Nadezhda V. Cherdyntseva, Matvey M. Tsyganov, Еlena М. Slonimskaya, Marina K. Ibragimova, Polina V. Kazantseva, Julia Kzhyshkowska,  and Eugeniy L. Choinzonov
7829-7841
Abstract  |  PDF  |  HTML  |  Order a Reprint

Recruited mast cells in the tumor microenvironment enhance bladder cancer metastasis via modulation of ERβ/CCL2/CCR2 EMT/MMP9 signals

Recruited mast cells in the tumor microenvironment enhance bladder cancer metastasis via modulation of ERβ/CCL2/CCR2 EMT/MMP9 signals

https://doi.org/10.18632/oncotarget.5467

Qun Rao, Yuan Chen, Chiuan-Ren Yeh, Jie Ding, Lei Li, Chawnshang Chang,  and Shuyuan Yeh
7842-7855
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

GPR171 expression enhances proliferation and metastasis of lung cancer cells

GPR171 expression enhances proliferation and metastasis of lung cancer cells

https://doi.org/10.18632/oncotarget.6856

So Hee Dho, Kwang-Pyo Lee, Dongjun Jeong, Chang-Jin Kim, Kyung-Sook Chung, Ji Young Kim, Bum-Chan Park, Sung Sup Park, Seon-Young Kim,  and Ki-Sun Kwon
7856-7865
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Long lasting MDM2/Translocator protein modulator: a new strategy for irreversible apoptosis of human glioblastoma cells

Long lasting MDM2/Translocator protein modulator: a new strategy for irreversible apoptosis of human glioblastoma cells

https://doi.org/10.18632/oncotarget.6872

Simona Daniele, Elisabetta Barresi, Elisa Zappelli, Luciana Marinelli, Ettore Novellino, Federico Da Settimo, Sabrina Taliani, Maria L. Trincavelli,  and Claudia Martini
7866-7884
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

PTEN deficiency promotes macrophage infiltration and hypersensitivity of prostate cancer to IAP antagonist/radiation combination therapy

PTEN deficiency promotes macrophage infiltration and hypersensitivity of prostate cancer to IAP antagonist/radiation combination therapy

https://doi.org/10.18632/oncotarget.6955

Chris W.D. Armstrong, Pamela J. Maxwell, Chee Wee Ong, Kelly M. Redmond, Christopher McCann, Jessica Neisen, George A. Ward, Gianni Chessari, Christopher Johnson, Nyree T. Crawford, Melissa J. LaBonte, Kevin M. Prise, Tracy Robson, Manuel Salto-Tellez, Daniel B. Longley,  and David J.J. Waugh
7885-7898
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Inhibition of NADPH oxidase 1 activity and blocking the binding of cytosolic and membrane-bound proteins by honokiol inhibit migratory potential of melanoma cells

Inhibition of NADPH oxidase 1 activity and blocking the binding of cytosolic and membrane-bound proteins by honokiol inhibit migratory potential of melanoma cells

https://doi.org/10.18632/oncotarget.6860

Ram Prasad, John C. Kappes,  and Santosh K. Katiyar
7899-7912
Abstract  |  PDF  |  HTML  |  Order a Reprint

The role of PD-L1 in the radiation response and prognosis for esophageal squamous cell carcinoma related to IL-6 and T-cell immunosuppression

The role of PD-L1 in the radiation response and prognosis for esophageal squamous cell carcinoma related to IL-6 and T-cell immunosuppression

https://doi.org/10.18632/oncotarget.6861

Miao-Fen Chen, Ping-Tsung Chen, Wen-Cheng Chen, Ming-Shian Lu, Paul-Yang Lin,  and Kuan-Der Lee
7913-7924
Abstract  |  PDF  |  HTML  |  Order a Reprint

Dlx-2 and glutaminase upregulate epithelial-mesenchymal transition and glycolytic switch

Dlx-2 and glutaminase upregulate epithelial-mesenchymal transition and glycolytic switch

https://doi.org/10.18632/oncotarget.6879

Su Yeon Lee, Hyun Min Jeon, Min Kyung Ju, Eui Kyong Jeong, Cho Hee Kim, Hye Gyeong Park, Song Iy Han,  and Ho Sung Kang
7925-7939
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The prognostic effects of tumor infiltrating regulatory T cells and myeloid derived suppressor cells assessed by multicolor flow cytometry in gastric cancer patients

The prognostic effects of tumor infiltrating regulatory T cells and myeloid derived suppressor cells assessed by multicolor flow cytometry in gastric cancer patients

https://doi.org/10.18632/oncotarget.6958

Han Sol Choi, Sang Yun Ha, Hye-Mi Kim, Soo Min Ahn, Myung-Soo Kang, Kyoung-Mee Kim, Min Gew Choi, Joon Ho Lee, Tae Sung Sohn, Jae Moon Bae, Sung Kim,  and Eun-Suk Kang
7940-7951
Abstract  |  PDF  |  HTML  |  Order a Reprint

Prognostic value of lymph node ratio in stage IIIC epithelial ovarian cancer with node-positive in a SEER population-based study

Prognostic value of lymph node ratio in stage IIIC epithelial ovarian cancer with node-positive in a SEER population-based study

https://doi.org/10.18632/oncotarget.6911

Juan Zhou, Zhen-Yu He, Feng-Yan Li, Jia-Yuan Sun, Huan-Xin Lin, San-Gang Wu,  and Qiong-Hua Chen
7952-7959
Abstract  |  PDF  |  HTML  |  Order a Reprint

Effects of RAF inhibitors on PI3K/AKT signalling depend on mutational status of the RAS/RAF signalling axis

Effects of RAF inhibitors on PI3K/AKT signalling depend on mutational status of the RAS/RAF signalling axis

https://doi.org/10.18632/oncotarget.6959

Raphaela Fritsche-Guenther, Franziska Witzel, Stefan Kempa, Tilman Brummer, Christine Sers,  and Nils Blüthgen
7960-7969
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Aberrant NRP-1 expression serves as predicator of metastatic endometrial and lung cancers

Aberrant NRP-1 expression serves as predicator of metastatic endometrial and lung cancers

https://doi.org/10.18632/oncotarget.6699

Imoh S. Okon, Ye Ding, Kathleen A. Coughlan, Qiongxin Wang, Ping Song, Doris M. Benbrook,  and Ming-Hui Zou
7970-7978
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Inhibition of breast cancer cell motility with a non-cyclooxygenase inhibitory derivative of sulindac by suppressing TGFβ/miR-21 signaling

Inhibition of breast cancer cell motility with a non-cyclooxygenase inhibitory derivative of sulindac by suppressing TGFβ/miR-21 signaling

https://doi.org/10.18632/oncotarget.6888

Bin Yi, Hong Chang, Ruixia Ma, Xiangling Feng, Wei Li, Gary A. Piazza,  and Yaguang Xi
7979-7992
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Patient-derived xenograft (PDX) tumors increase growth rate with time

Patient-derived xenograft (PDX) tumors increase growth rate with time

https://doi.org/10.18632/oncotarget.6919

Alexander T. Pearson, Kelsey A. Finkel, Kristy A. Warner, Felipe Nör, David Tice, Manoela D. Martins, Trachette L. Jackson,  and Jacques E. Nör
7993-8005
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Gene copy number variations in the leukocyte genome of hepatocellular carcinoma patients with integrated hepatitis B virus DNA

Gene copy number variations in the leukocyte genome of hepatocellular carcinoma patients with integrated hepatitis B virus DNA

https://doi.org/10.18632/oncotarget.6895

Yanan Pang, Weixing Guo, Jiaqi Wang, Guixia Xu, Kai Cheng, Guangwen Cao, Mengchao Wu, Shuqun Cheng,  and Shanrong Liu
8006-8018
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

ROS1 copy number alterations are frequent in non-small cell lung cancer

ROS1 copy number alterations are frequent in non-small cell lung cancer

https://doi.org/10.18632/oncotarget.6921

Sergi Clavé, Javier Gimeno, Ana M. Muñoz-Mármol, Joana Vidal, Noemí Reguart, Enric Carcereny, Lara Pijuan, Sílvia Menéndez, Álvaro Taus, José Luís Mate, Sergio Serrano, Joan Albanell, Blanca Espinet, Edurne Arriola,  and Marta Salido
8019-8028
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ZYG11A serves as an oncogene in non-small cell lung cancer and influences CCNE1 expression

ZYG11A serves as an oncogene in non-small cell lung cancer and influences CCNE1 expression

https://doi.org/10.18632/oncotarget.6904

Xin Wang, Qi Sun, Chen Chen, Rong Yin, Xing Huang, Xuan Wang, Run Shi, Lin Xu,  and Binhui Ren
8029-8042
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Lentivirus-mediated PLCγ1 gene short-hairpin RNA suppresses tumor growth and metastasis of human gastric adenocarcinoma

Lentivirus-mediated PLCγ1 gene short-hairpin RNA suppresses tumor growth and metastasis of human gastric adenocarcinoma

https://doi.org/10.18632/oncotarget.6976

Bingchang Zhang, Fen Wang, Lianzhi Dai, Heguo Cai, Yanyan Zhan, Song Gang, Tianhui Hu, Chun Xia,  and Bing Zhang
8043-8054
Abstract  |  PDF  |  HTML  |  Order a Reprint

Genetic alterations and their clinical implications in gastric cancer peritoneal carcinomatosis revealed by whole-exome sequencing of malignant ascites

Genetic alterations and their clinical implications in gastric cancer peritoneal carcinomatosis revealed by whole-exome sequencing of malignant ascites

https://doi.org/10.18632/oncotarget.6977

Byungho Lim, Chan Kim, Jeong-Hwan Kim, Woo Sun Kwon, Won Seok Lee, Jeong Min Kim, Jun Yong Park, Hyo Song Kim, Kyu Hyun Park, Tae Soo Kim, Jong-Lyul Park, Hyun Cheol Chung, Sun Young Rha,  and Seon-Young Kim
8055-8066
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Fractionation of a tumor-initiating UV dose introduces DNA damage-retaining cells in hairless mouse skin and renders subsequent TPA-promoted tumors non-regressing

Fractionation of a tumor-initiating UV dose introduces DNA damage-retaining cells in hairless mouse skin and renders subsequent TPA-promoted tumors non-regressing

https://doi.org/10.18632/oncotarget.6932

Gerline van de Glind, Heggert Rebel, Marika van Kempen, Kees Tensen,  and Frank de Gruijl
8067-8077
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CTNNA3 is a tumor suppressor in hepatocellular carcinomas and is inhibited by miR-425

CTNNA3 is a tumor suppressor in hepatocellular carcinomas and is inhibited by miR-425

https://doi.org/10.18632/oncotarget.6978

Bing He, Ting Li, Lei Guan, Fang-E Liu, Xue-Mei Chen, Jing Zhao, Song Lin, Zhi-Zhen Liu,  and Hu-Qin Zhang
8078-8089
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Hernandezine, a novel AMPK activator induces autophagic cell death in drug-resistant cancers

Hernandezine, a novel AMPK activator induces autophagic cell death in drug-resistant cancers

https://doi.org/10.18632/oncotarget.6980

Betty Yuen Kwan Law, Simon Wing Fai Mok, Wai Kit Chan, Su Wei Xu, An Guo Wu, Xiao Jun Yao, Jing Rong Wang, Liang Liu,  and Vincent Kam Wai Wong
8090-8104
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Hydroxyurea synergizes with valproic acid in wild-type p53 acute myeloid leukaemia

Hydroxyurea synergizes with valproic acid in wild-type p53 acute myeloid leukaemia

https://doi.org/10.18632/oncotarget.6991

Calum Leitch, Tereza Osdal, Vibeke Andresen, Maren Molland, Silje Kristiansen, Xuan Nhi Nguyen, Øystein Bruserud, Bjørn Tore Gjertsen,  and Emmet McCormack
8105-8118
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Genomic loss of EZH2 leads to epigenetic modifications and overexpression of the HOX gene clusters in myelodysplastic syndrome

Genomic loss of EZH2 leads to epigenetic modifications and overexpression of the HOX gene clusters in myelodysplastic syndrome

https://doi.org/10.18632/oncotarget.6992

Feng Xu, Li Liu, Chun-Kang Chang, Qi He, Ling-Yun Wu, Zheng Zhang, Wen-Hui Shi, Juan Guo, Yang Zhu, You-Shan Zhao, Shu-Cheng Gu, Cheng- Ming Fei,  and Xiao Li
8119-8130
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Transcriptional profiling analysis and functional prediction of long noncoding RNAs in cancer

Transcriptional profiling analysis and functional prediction of long noncoding RNAs in cancer

https://doi.org/10.18632/oncotarget.6993

Jiao Yuan, Haiyan Yue, Meiying Zhang, Jianjun Luo, Lihui Liu, Wei Wu, Tengfei Xiao, Xiaowei Chen, Xiaomin Chen, Dongdong Zhang, Rui Xing, Xin Tong, Nan Wu, Jian Zhao, Youyong Lu, Mingzhou Guo,  and Runsheng Chen
8131-8142
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Expression of aquaporin1, a water channel protein, in cytoplasm is negatively correlated with prognosis of breast cancer patients

Expression of aquaporin1, a water channel protein, in cytoplasm is negatively correlated with prognosis of breast cancer patients

https://doi.org/10.18632/oncotarget.6994

Fengxia Qin, Huikun Zhang, Ying Shao, Xiaoli Liu, Limin Yang, Yong Huang, Li Fu, Feng Gu,  and Yongjie Ma
8143-8154
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Multiple direct and indirect mechanisms drive estrogen-induced tumor growth in high grade serous ovarian cancers

Multiple direct and indirect mechanisms drive estrogen-induced tumor growth in high grade serous ovarian cancers

https://doi.org/10.18632/oncotarget.6943

Alessandra Ciucci, Gian Franco Zannoni, Marianna Buttarelli, Lucia Lisi, Daniele Travaglia, Enrica Martinelli, Giovanni Scambia,  and Daniela Gallo
8155-8171
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Identification of approved and investigational drugs that inhibit hypoxia-inducible factor-1 signaling

Identification of approved and investigational drugs that inhibit hypoxia-inducible factor-1 signaling

https://doi.org/10.18632/oncotarget.6995

Chia-Wen Hsu, Ruili Huang, Thai Khuc, David Shou, Joshua Bullock, Suzanne Grooby, Sue Griffin, Chaozhong Zou, Annette Little, Holly Astley,  and Menghang Xia
8172-8183
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

p38 MAPK-induced MDM2 degradation confers paclitaxel resistance through p53-mediated regulation of EGFR in human lung cancer cells

p38 MAPK-induced MDM2 degradation confers paclitaxel resistance through p53-mediated regulation of EGFR in human lung cancer cells

https://doi.org/10.18632/oncotarget.6945

Shin-Hyung Park, Myeong-A Seong,  and Ho-Young Lee
8184-8199
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

LOX expression in primary nasopharyngeal carcinoma: correlation with prognostic parameters and outcome

LOX expression in primary nasopharyngeal carcinoma: correlation with prognostic parameters and outcome

https://doi.org/10.18632/oncotarget.6996

Yi-Jun Hua, Hai-Yun Wang, Ling-Quan Tang, Qiu-Yan Chen, Jian-Yong Shao,  and Hai-Qiang Mai
8200-8207
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A SNP in pri-miR-10a is associated with recurrent spontaneous abortion in a Han-Chinese population

A SNP in pri-miR-10a is associated with recurrent spontaneous abortion in a Han-Chinese population

https://doi.org/10.18632/oncotarget.7002

Ying Li, Xue-Qin Wang, Lu Zhang, Xiao-Dan Lv, Xing Su, Shi Tian, Chun-Mei Liu, Xu Ma,  and Hong-Fei Xia
8208-8222
Abstract  |  PDF  |  HTML  |  Order a Reprint

microRNA-203 suppresses invasion and epithelial-mesenchymal transition induction via targeting NUAK1 in head and neck cancer

microRNA-203 suppresses invasion and epithelial-mesenchymal transition induction via targeting NUAK1 in head and neck cancer

https://doi.org/10.18632/oncotarget.6972

Mariko Obayashi, Maki Yoshida, Takaaki Tsunematsu, Ikuko Ogawa, Tomonori Sasahira, Hiroki Kuniyasu, Issei Imoto, Yoshimitsu Abiko, Dan Xu, Saori Fukunaga, Hidetoshi Tahara, Yasusei Kudo, Toshitaka Nagao,  and Takashi Takata
8223-8239
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

TSGΔ154-1054 splice variant increases TSG101 oncogenicity by inhibiting its E3-ligase-mediated proteasomal degradation

TSGΔ154-1054 splice variant increases TSG101 oncogenicity by inhibiting its E3-ligase-mediated proteasomal degradation

https://doi.org/10.18632/oncotarget.6973

Huey-Huey Chua, Chiun-Sheng Huang, Pei-Lun Weng,  and Te-Huei Yeh
8240-8252
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Targeting glucosylceramide synthase upregulation reverts sorafenib resistance in experimental hepatocellular carcinoma

Targeting glucosylceramide synthase upregulation reverts sorafenib resistance in experimental hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.6982

Milica Stefanovic, Anna Tutusaus, Guillermo A. Martinez-Nieto, Cristina Bárcena, Estefania de Gregorio, Catia Moutinho, Elisabet Barbero-Camps, Alberto Villanueva, Anna Colell, Montserrat Marí, Carmen García-Ruiz, Jose C. Fernandez-Checa,  and Albert Morales
8253-8267
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

microRNAs regulate TAL1 expression in T-cell acute lymphoblastic leukemia

microRNAs regulate TAL1 expression in T-cell acute lymphoblastic leukemia

https://doi.org/10.18632/oncotarget.6987

Nádia C. Correia, Alice Melão, Vanda Póvoa, Leonor Sarmento, Marta Gómez de Cedrón, Marcos Malumbres, Francisco J. Enguita,  and João T. Barata
8268-8281
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Identification of an aptamer through whole cell-SELEX for targeting high metastatic liver cancers

Identification of an aptamer through whole cell-SELEX for targeting high metastatic liver cancers

https://doi.org/10.18632/oncotarget.6988

Yuan Rong, Hao Chen, Xue-Feng Zhou, Chang-Qing Yin, Bi-Cheng Wang, Chun-Wei Peng, Shao-Ping Liu,  and Fu-Bing Wang
8282-8294
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A novel contribution of spvB to pathogenesis of Salmonella Typhimurium by inhibiting autophagy in host cells

A novel contribution of spvB to pathogenesis of Salmonella Typhimurium by inhibiting autophagy in host cells

https://doi.org/10.18632/oncotarget.6989

Yuanyuan Chu, Song Gao, Ting Wang, Jing Yan, Guangmei Xu, Yuanyuan Li, Hua Niu, Rui Huang,  and Shuyan Wu
8295-8309
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Multiple gene sequencing for risk assessment in patients with early-onset or familial breast cancer

Multiple gene sequencing for risk assessment in patients with early-onset or familial breast cancer

https://doi.org/10.18632/oncotarget.7027

Po-Han Lin, Wen-Hung Kuo, Ai-Chu Huang, Yen-Shen Lu, Ching-Hung Lin, Sung-Hsin Kuo, Ming-Yang Wang, Chun-Yu Liu, Fiona Tsui-Fen Cheng, Ming-Hsin Yeh, Huei-Ying Li, Yu-Hsuan Yang, Yu-Hua Hsu, Sheng-Chih Fan, Long-Yuan Li, Sung-Liang Yu, King-Jen Chang, Pei-Lung Chen, Yen-Hsuan Ni,  and Chiun-Sheng Huang
8310-8320
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Whole exome and targeted deep sequencing identify genome-wide allelic loss and frequent SETDB1 mutations in malignant pleural mesotheliomas

Whole exome and targeted deep sequencing identify genome-wide allelic loss and frequent SETDB1 mutations in malignant pleural mesotheliomas

https://doi.org/10.18632/oncotarget.7032

Hio Chung Kang, Hong Kwan Kim, Sharon Lee, Pedro Mendez, James Wansoo Kim, Gavitt Woodard, Jun-Hee Yoon, Kuang-Yu Jen, Li Tai Fang, Kirk Jones, David M. Jablons,  and Il-Jin Kim
8321-8331
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Assessment of cytology based molecular analysis to guide targeted therapy in advanced non-small-cell lung cancer

Assessment of cytology based molecular analysis to guide targeted therapy in advanced non-small-cell lung cancer

https://doi.org/10.18632/oncotarget.6671

Wenbin Li, Zhihui Zhang, Lei Guo, Tian Qiu, Yun Ling, Jian Cao, Huiqin Guo, Huan Zhao, Lin Li,  and Jianming Ying
8332-8340
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Hsa-miR-326 targets CCND1 and inhibits non-small cell lung cancer development

Hsa-miR-326 targets CCND1 and inhibits non-small cell lung cancer development

https://doi.org/10.18632/oncotarget.7071

Chengcao Sun, Chuanfeng Huang, Shujun Li, Cuili Yang, Yongyong Xi, Liang Wang, Feng Zhang, Yunfeng Fu,  and Dejia Li
8341-8359
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Toward targeted therapy in chemotherapy-resistant pancreatic cancer with a smart triptolide nanomedicine

Toward targeted therapy in chemotherapy-resistant pancreatic cancer with a smart triptolide nanomedicine

https://doi.org/10.18632/oncotarget.7073

Cheng Wang, Biao Liu, Xuelian Xu, Bo Zhuang, Hongxia Li, Jiaqi Yin, Mengyi Cong, Wei Xu,  and Aiping Lu
8360-8372
Abstract  |  PDF  |  HTML  |  Order a Reprint

KRAS mutation is a weak, but valid predictor for poor prognosis and treatment outcomes in NSCLC: A meta-analysis of 41 studies

KRAS mutation is a weak, but valid predictor for poor prognosis and treatment outcomes in NSCLC: A meta-analysis of 41 studies

https://doi.org/10.18632/oncotarget.7080

Wei Pan, Yan Yang, Hongcheng Zhu, Youcheng Zhang, Rongping Zhou,  and Xinchen Sun
8373-8388
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Clinical Research Papers

Serum chemokine (CC motif) ligand 2 level as a diagnostic, predictive, and prognostic biomarker for prostate cancer

Serum chemokine (CC motif) ligand 2 level as a diagnostic, predictive, and prognostic biomarker for prostate cancer

https://doi.org/10.18632/oncotarget.6690

Kouji Izumi, Atsushi Mizokami, Hsiu-Ping Lin, Hui-Min Ho, Hiroaki Iwamoto, Aerken Maolake, Ariunbold Natsagdorj, Yasuhide Kitagawa, Yoshifumi Kadono, Hiroshi Miyamoto, Chiung-Kuei Huang, Mikio Namiki,  and Wen-Jye Lin
8389-8398
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

NTRK1 fusions for the therapeutic intervention of Korean patients with colon cancer

NTRK1 fusions for the therapeutic intervention of Korean patients with colon cancer

https://doi.org/10.18632/oncotarget.6724

Do Youn Park, Chan Choi, Eunji Shin, Jae Hyuk Lee, Chae Hwa Kwon, Hong-Jae Jo, Hyeong-Rok Kim, Hyun Sung Kim, Nahmgun Oh, Ji Shin Lee, Ok Ku Park, Eok Park, Jonghoon Park, Jong-Yeon Shin, Jong-Il Kim, Jeong-Sun Seo, Hee Dong Park,  and Joonghoon Park
8399-8412
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Positive intratumoral chemokine (C-C motif) receptor 8 expression predicts high recurrence risk of post-operation clear-cell renal cell carcinoma patients

Positive intratumoral chemokine (C-C motif) receptor 8 expression predicts high recurrence risk of post-operation clear-cell renal cell carcinoma patients

https://doi.org/10.18632/oncotarget.6761

Qiang Fu, Yuan Chang, Lin Zhou, Huimin An, Yu Zhu, Le Xu, Weijuan Zhang,  and Jiejie Xu
8413-8421
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Phase III study of cisplatin with pemtrexed or vinorelbine plus concurrent late course accelerated hyperfractionated radiotherapy in patients with unresectable stage III non-small cell lung cancer

Phase III study of cisplatin with pemtrexed or vinorelbine plus concurrent late course accelerated hyperfractionated radiotherapy in patients with unresectable stage III non-small cell lung cancer

https://doi.org/10.18632/oncotarget.6871

Qian Zhao, Zhongtang Wang, Wei Huang, Qiang Wang, Shuzeng Yu, Tao Zhou, Dan Han, Zhenying Wu, Heyi Gong, Hongfu Sun, Jian Zhang, Yumei Wei, Hongsheng Li, Zicheng Zhang, Haiqun Lin,  and Baosheng Li
8422-8431
Abstract  |  PDF  |  HTML  |  Order a Reprint

The effect of perioperative probiotics treatment for colorectal cancer: short-term outcomes of a randomized controlled trial

The effect of perioperative probiotics treatment for colorectal cancer: short-term outcomes of a randomized controlled trial

https://doi.org/10.18632/oncotarget.7045

Yongzhi Yang, Yang Xia, Hongqi Chen, Leiming Hong, Junlan Feng, Jun Yang, Zhe Yang, Chenzhang Shi, Wen Wu, Renyuan Gao, Qing Wei, Huanlong Qin,  and Yanlei Ma
8432-8440
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