Oncotarget

Vol 7, No 6

February 9, 2016

View Archive »

Order a Reprint

About The Cover

Disruption of KIF3A in patient-derived glioblastoma cells: effects on ciliogenesis, hedgehog sensitivity, and tumorigenesis. See Hoang-Minh et al.

Table of Contents

Priority Research Papers

Germline polymorphisms in an enhancer of PSIP1 are associated with progression-free survival in epithelial ovarian cancer

Germline polymorphisms in an enhancer of PSIP1 are associated with progression-free survival in epithelial ovarian cancer

https://doi.org/10.18632/oncotarget.7047

Juliet D. French, Sharon E. Johnatty, Yi Lu, Jonathan Beesley, Bo Gao, Murugan Kalimutho, Michelle J. Henderson, Amanda J. Russell, Siddhartha Kar, Xiaoqing Chen, Kristine M. Hillman, Susanne Kaufmann, Haran Sivakumaran, Martin O’Reilly, Chen Wang, Darren J. Korbie, Australian Ovarian Cancer Study Group, Australian Cancer Study, Diether Lambrechts, Evelyn Despierre, Els Van Nieuwenhuysen, Sandrina Lambrechts, Ignace Vergote, Beth Karlan, Jenny Lester, Sandra Orsulic, Christine Walsh, Peter A. Fasching, Matthias W. Beckmann, Arif B. Ekici, Alexander Hein, Keitaro Matsuo, Satoyo Hosono, Jacobus Pisterer, Peter Hillemanns, Toru Nakanishi, Yasushi Yatabe, Marc T. Goodman, Galina Lurie, Rayna K. Matsuno, Pamela J. Thompson, Tanja Pejovic, Yukie Bean, Florian Heitz, Philipp Harter, Andreas du Bois, Ira Schwaab, Estrid Hogdall, Susanne K. Kjaer, Allan Jensen, Claus Hogdall, Lene Lundvall, Svend Aage Engelholm, Bob Brown, James M. Flanagan, Michelle D. Metcalf, Nadeem Siddiqui, Thomas Sellers, Brooke Fridley, Julie Cunningham, Joellen M. Schildkraut, Ed Iversen, Rachel Palmieri Weber, Donal Brennan, Andrew Berchuck, Paul Pharoah, Paul Harnett, Murray D. Norris, Michelle Haber, Ellen L. Goode, Jason S. Lee, Kum Kum Khanna, Kerstin B. Meyer, Georgia Chenevix-Trench, Anna deFazio, Stacey L. Edwards, Stuart MacGregor,  and on behalf of the Ovarian Cancer Association Consortium
6353-6368
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

CEST theranostics: label-free MR imaging of anticancer drugs

CEST theranostics: label-free MR imaging of anticancer drugs

https://doi.org/10.18632/oncotarget.7141

Yuguo Li, Hanwei Chen, Jiadi Xu, Nirbhay N. Yadav, Kannie W. Y. Chan, Liangping Luo, Michael T. McMahon, Bert Vogelstein, Peter C.M. van Zijl, Shibin Zhou,  and Guanshu Liu
6369-6378
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

PRDX2 and PRDX4 are negative regulators of hypoxia-inducible factors under conditions of prolonged hypoxia

PRDX2 and PRDX4 are negative regulators of hypoxia-inducible factors under conditions of prolonged hypoxia

https://doi.org/10.18632/oncotarget.7142

Weibo Luo, Ivan Chen, Yan Chen, Duah Alkam, Yingfei Wang,  and Gregg L. Semenza
6379-6397
Abstract  |  PDF  |  HTML  |  Order a Reprint

Research Papers: Gerotarget (Focus on Aging)

The effects of aging and maternal protein restriction during lactation on thymic involution and peripheral immunosenescence in adult mice

The effects of aging and maternal protein restriction during lactation on thymic involution and peripheral immunosenescence in adult mice

https://doi.org/10.18632/oncotarget.7176

Chantal A. A. Heppolette, Jian-Hua Chen, Sarah K. Carr, Donald B. Palmer,  and Susan E. Ozanne
6398-6409
Abstract  |  PDF  |  HTML  |  Order a Reprint

Research Papers: Pathology

Extracorporeal Shock Wave Treatment (ESWT) enhances the in vitro-induced differentiation of human tendon-derived stem/progenitor cells (hTSPCs)

Extracorporeal Shock Wave Treatment (ESWT) enhances the in vitro-induced differentiation of human tendon-derived stem/progenitor cells (hTSPCs)

https://doi.org/10.18632/oncotarget.7064

Laura Leone, Salvatore Raffa, Mario Vetrano, Danilo Ranieri, Florence Malisan, Cristina Scrofani, Maria Chiara Vulpiani, Andrea Ferretti, Maria Rosaria Torrisi,  and Vincenzo Visco
6410-6423
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Research Papers: Immunology

Residual tumor micro-foci and overwhelming regulatory T lymphocyte infiltration are the causes of bladder cancer recurrence

Residual tumor micro-foci and overwhelming regulatory T lymphocyte infiltration are the causes of bladder cancer recurrence

https://doi.org/10.18632/oncotarget.7024

Alessia Parodi, Paolo Traverso, Francesca Kalli, Giuseppina Conteduca, Samuele Tardito, Monica Curto, Federica Grillo, Luca Mastracci, Cinzia Bernardi, Giorgia Nasi, Francesco Minaglia, Alchiede Simonato, Giorgio Carmignani, Francesca Ferrera, Daniela Fenoglio,  and Gilberto Filaci
6424-6435
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Up-regulation of immunomodulatory effects of mouse bone-marrow derived mesenchymal stem cells by tetrahydrocannabinol pre-treatment involving cannabinoid receptor CB2

Up-regulation of immunomodulatory effects of mouse bone-marrow derived mesenchymal stem cells by tetrahydrocannabinol pre-treatment involving cannabinoid receptor CB2

https://doi.org/10.18632/oncotarget.7042

Junran Xie, Dongju Xiao, Yun Xu, Jinning Zhao, Li Jiang, Xuming Hu, Yaping Zhang,  and Lina Yu
6436-6447
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Human melanoma immunotherapy using tumor antigen-specific T cells generated in humanized mice

Human melanoma immunotherapy using tumor antigen-specific T cells generated in humanized mice

https://doi.org/10.18632/oncotarget.7044

Zheng Hu, Jinxing Xia, Wei Fan, Jennifer Wargo,  and Yong-Guang Yang
6448-6459
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Research Papers: Chromosome

Hierarchical regulation of the genome: global changes in nucleosome organization potentiate genome response

Hierarchical regulation of the genome: global changes in nucleosome organization potentiate genome response

https://doi.org/10.18632/oncotarget.6841

Brittany S. Sexton, Brooke R. Druliner, Daniel L. Vera, Denis Avey, Fanxiu Zhu,  and Jonathan H. Dennis
6460-6475
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Reviews

MicroRNAs as growth regulators, their function and biomarker status in colorectal cancer

MicroRNAs as growth regulators, their function and biomarker status in colorectal cancer

https://doi.org/10.18632/oncotarget.6390

Lina Cekaite, Peter W. Eide, Guro E. Lind, Rolf I. Skotheim,  and Ragnhild A. Lothe
6476-6505
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Understanding the role of the kynurenine pathway in human breast cancer immunobiology

Understanding the role of the kynurenine pathway in human breast cancer immunobiology

https://doi.org/10.18632/oncotarget.6467

Benjamin Heng, Chai K. Lim, David B. Lovejoy, Alban Bessede, Laurence Gluch,  and Gilles J. Guillemin
6506-6520
Abstract  |  PDF  |  HTML  |  Order a Reprint

Novel strategies to target the ubiquitin proteasome system in multiple myeloma

Novel strategies to target the ubiquitin proteasome system in multiple myeloma

https://doi.org/10.18632/oncotarget.6658

Susanne Lub, Ken Maes, Eline Menu, Elke De Bruyne, Karin Vanderkerken,  and Els Van Valckenborgh
6521-6537
Abstract  |  PDF  |  HTML  |  Order a Reprint

Research Papers

Integrated genomic analyses identify frequent gene fusion events and VHL inactivation in gastrointestinal stromal tumors

Integrated genomic analyses identify frequent gene fusion events and VHL inactivation in gastrointestinal stromal tumors

https://doi.org/10.18632/oncotarget.3731

Guhyun Kang, Hongseok Yun, Choong-Hyun Sun, Inho Park, Seungmook Lee, Jekeun Kwon, Ingu Do, Min Eui Hong, Michael Van Vrancken, Jeeyun Lee, Joon Oh Park, Jeonghee Cho, Kyoung-Mee Kim,  and Tae Sung Sohn
6538-6551
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

RUNX1 and FOXP3 interplay regulates expression of breast cancer related genes

RUNX1 and FOXP3 interplay regulates expression of breast cancer related genes

https://doi.org/10.18632/oncotarget.6771

María Sol Recouvreux, Esteban Nicolás Grasso, Pablo Christian Echeverria, Luciana Rocha-Viegas, Lucio Hernán Castilla, Carolina Schere-Levy, Johanna Melisa Tocci, Edith Claudia Kordon,  and Natalia Rubinstein
6552-6565
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

SLC7A5 act as a potential leukemic transformation target gene in myelodysplastic syndrome

SLC7A5 act as a potential leukemic transformation target gene in myelodysplastic syndrome

https://doi.org/10.18632/oncotarget.6512

Yan Ma, Jing Song, Bobin Chen, Xiaoping Xu,  and Guowei Lin
6566-6575
Abstract  |  PDF  |  HTML  |  Order a Reprint

Dual mTOR inhibitor MLN0128 suppresses Merkel cell carcinoma (MCC) xenograft tumor growth

Dual mTOR inhibitor MLN0128 suppresses Merkel cell carcinoma (MCC) xenograft tumor growth

https://doi.org/10.18632/oncotarget.5878

Aarthi Kannan, Zhenyu Lin, Qiang Shao, Stephanie Zhao, Bin Fang, Mauricio A. Moreno, Emre Vural, Brendan C. Stack, Jr., James Y. Suen, Krishnaswamy Kannan,  and Ling Gao
6576-6592
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Presence of sst5TMD4, a truncated splice variant of the somatostatin receptor subtype 5, is associated to features of increased aggressiveness in pancreatic neuroendocrine tumors

Presence of sst5TMD4, a truncated splice variant of the somatostatin receptor subtype 5, is associated to features of increased aggressiveness in pancreatic neuroendocrine tumors

https://doi.org/10.18632/oncotarget.6565

Miguel Sampedro-Núñez, Raúl M. Luque, Ana M. Ramos-Levi, Manuel D. Gahete, Ana Serrano-Somavilla, Alicia Villa-Osaba, Magdalena Adrados, Alejandro Ibáñez-Costa, Elena Martín-Pérez, Michael D. Culler, Mónica Marazuela,  and Justo P. Castaño
6593-6608
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Identification and validation of the dopamine agonist bromocriptine as a novel therapy for high-risk myelodysplastic syndromes and secondary acute myeloid leukemia

Identification and validation of the dopamine agonist bromocriptine as a novel therapy for high-risk myelodysplastic syndromes and secondary acute myeloid leukemia

https://doi.org/10.18632/oncotarget.6773

Fabio Giuseppe Liberante, Tara Pouryahya, Mary-Frances McMullin, Shu-Dong Zhang,  and Kenneth Ian Mills
6609-6619
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The mitochondrial genetic landscape in neuroblastoma from tumor initiation to relapse

The mitochondrial genetic landscape in neuroblastoma from tumor initiation to relapse

https://doi.org/10.18632/oncotarget.6776

Lara M. Riehl, Johannes H. Schulte, Medhanie A. Mulaw, Meike Dahlhaus, Matthias Fischer, Alexander Schramm, Angelika Eggert, Klaus-Michael Debatin,  and Christian Beltinger
6620-6625
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

IL-6 promotes growth and epithelial-mesenchymal transition of CD133+ cells of non-small cell lung cancer

IL-6 promotes growth and epithelial-mesenchymal transition of CD133+ cells of non-small cell lung cancer

https://doi.org/10.18632/oncotarget.6570

Soo Ok Lee, Xiaodong Yang, Shanzhou Duan, Ying Tsai, Laura R. Strojny, Peter Keng,  and Yuhchyau Chen
6626-6638
Abstract  |  PDF  |  HTML  |  Order a Reprint

Safety and efficacy of sorafenib therapy in patients with hepatocellular carcinoma: final outcome from the Chinese patient subset of the GIDEON study

Safety and efficacy of sorafenib therapy in patients with hepatocellular carcinoma: final outcome from the Chinese patient subset of the GIDEON study

https://doi.org/10.18632/oncotarget.6781

Sheng-Long Ye, Xiaoping Chen, Jiamei Yang, Ping Bie, Shuijun Zhang, Fengyong Liu, Luming Liu, Jie Zhou, Kefeng Dou, Chunyi Hao, Guoliang Shao, Qiang Xia, Yajin Chen, Jijin Yang, Xiaxing Deng, Yunpeng Liu, Yunfei Yuan, Zhiren Fu, Keiko Nakajima, Christina S.M. Yip,  and Zhengguang Lu
6639-6648
Abstract  |  PDF  |  HTML  |  Order a Reprint

MicroRNA-372 inhibits endometrial carcinoma development by targeting the expression of the Ras homolog gene family member C (RhoC)

MicroRNA-372 inhibits endometrial carcinoma development by targeting the expression of the Ras homolog gene family member C (RhoC)

https://doi.org/10.18632/oncotarget.6544

Bo-Liang Liu, Kai-Xuan Sun, Zhi-Hong Zong, Shuo Chen,  and Yang Zhao
6649-6664
Abstract  |  PDF  |  HTML  |  Order a Reprint

ERK3 regulates TDP2-mediated DNA damage response and chemoresistance in lung cancer cells

ERK3 regulates TDP2-mediated DNA damage response and chemoresistance in lung cancer cells

https://doi.org/10.18632/oncotarget.6682

Ka Bian, Naveen Reddy Muppani, Lobna Elkhadragy, Wei Wang, Cheng Zhang, Tenghui Chen, Sungyun Jung, Ole Morten Seternes,  and Weiwen Long
6665-6675
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MiRNAs and piRNAs from bone marrow mesenchymal stem cell extracellular vesicles induce cell survival and inhibit cell differentiation of cord blood hematopoietic stem cells: a new insight in transplantation

MiRNAs and piRNAs from bone marrow mesenchymal stem cell extracellular vesicles induce cell survival and inhibit cell differentiation of cord blood hematopoietic stem cells: a new insight in transplantation

https://doi.org/10.18632/oncotarget.6791

Luciana De Luca, Stefania Trino, Ilaria Laurenzana, Vittorio Simeon, Giovanni Calice, Stefania Raimondo, Marina Podestà, Michele Santodirocco, Lazzaro Di Mauro, Francesco La Rocca, Antonella Caivano, Annalisa Morano, Francesco Frassoni, Daniela Cilloni, Luigi Del Vecchio,  and Pellegrino Musto
6676-6692
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Annexin A1 sustains tumor metabolism and cellular proliferation upon stable loss of HIF1A

Annexin A1 sustains tumor metabolism and cellular proliferation upon stable loss of HIF1A

https://doi.org/10.18632/oncotarget.6793

Nadine Rohwer, Fabian Bindel, Christina Grimm, Suling J. Lin, Jessica Wappler, Bertram Klinger, Nils Blüthgen, Ilona Du Bois, Bernd Schmeck, Hans Lehrach, Marjo de Graauw, Emanuel Goncalves, Julio Saez-Rodriguez, Patrick Tan, Heike I. Grabsch, Alessandro Prigione, Stefan Kempa,  and Thorsten Cramer
6693-6710
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

HBx regulates fatty acid oxidation to promote hepatocellular carcinoma survival during metabolic stress

HBx regulates fatty acid oxidation to promote hepatocellular carcinoma survival during metabolic stress

https://doi.org/10.18632/oncotarget.6817

Ming-Da Wang, Han Wu, Shuai Huang, Hui-Lu Zhang, Chen-Jie Qin, Ling-Hao Zhao, Gong-Bo Fu, Xu Zhou, Xian-Ming Wang, Liang Tang, Wen Wen, We Yang, Shan-Hua Tang, Dan Cao, Lin-Na Guo, Min Zeng, Meng-Chao Wu, He-Xin Yan,  and Hong-Yang Wang
6711-6726
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

HDAC inhibitors suppress c-Jun/Fra-1-mediated proliferation through transcriptionally downregulating MKK7 and Raf1 in neuroblastoma cells

HDAC inhibitors suppress c-Jun/Fra-1-mediated proliferation through transcriptionally downregulating MKK7 and Raf1 in neuroblastoma cells

https://doi.org/10.18632/oncotarget.6797

Weiwen He, Yanna Wu, Xiaomei Tang, Yong Xia, Guozhen He, Zhiqun Min, Chun Li, Shiqiu Xiong, Zhi Shi, Yongjian Lu,  and Zhongmin Yuan
6727-6747
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

TOPK promotes lung cancer resistance to EGFR tyrosine kinase inhibitors by phosphorylating and activating c-Jun

TOPK promotes lung cancer resistance to EGFR tyrosine kinase inhibitors by phosphorylating and activating c-Jun

https://doi.org/10.18632/oncotarget.6826

Ying Li, Zhiwei Yang, Weijie Li, Shudi Xu, Tao Wang, Ting Wang, Mengjie Niu, Shengli Zhang, Lintao Jia,  and Shengqing Li
6748-6764
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Is angiotensin-converting enzyme inhibitors/angiotensin receptor blockers therapy protective against prostate cancer?

Is angiotensin-converting enzyme inhibitors/angiotensin receptor blockers therapy protective against prostate cancer?

https://doi.org/10.18632/oncotarget.6837

Yeqing Mao, Xin Xu, Xiao Wang, Xiangyi Zheng,  and Liping Xie
6765-6773
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

NG2 proteoglycan as a pericyte target for anticancer therapy by tumor vessel infarction with retargeted tissue factor

NG2 proteoglycan as a pericyte target for anticancer therapy by tumor vessel infarction with retargeted tissue factor

https://doi.org/10.18632/oncotarget.6725

Caroline Brand, Christoph Schliemann, Janine Ring, Torsten Kessler, Sebastian Bäumer, Linus Angenendt, Verena Mantke, Rebecca Ross, Heike Hintelmann, Tilmann Spieker, Eva Wardelmann, Rolf M. Mesters, Wolfgang E. Berdel,  and Christian Schwöppe
6774-6789
Abstract  |  PDF  |  HTML  |  Order a Reprint

EM23, a natural sesquiterpene lactone, targets thioredoxin reductase to activate JNK and cell death pathways in human cervical cancer cells

EM23, a natural sesquiterpene lactone, targets thioredoxin reductase to activate JNK and cell death pathways in human cervical cancer cells

https://doi.org/10.18632/oncotarget.6828

Fang-Yuan Shao, Sheng Wang, Hong-Yu Li, Wen-Bo Chen, Guo-Cai Wang, Dong-Lei Ma, Nai Sum Wong, Hao Xiao, Qiu-Ying Liu, Guang-Xiong Zhou, Yao-Lan Li, Man-Mei Li, Yi-Fei Wang,  and Zhong Liu
6790-6808
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Genome-wide profiling of histone H3 lysine 27 and lysine 4 trimethylation in multiple myeloma reveals the importance of Polycomb gene targeting and highlights EZH2 as a potential therapeutic target

Genome-wide profiling of histone H3 lysine 27 and lysine 4 trimethylation in multiple myeloma reveals the importance of Polycomb gene targeting and highlights EZH2 as a potential therapeutic target

https://doi.org/10.18632/oncotarget.6843

Prasoon Agarwal, Mohammad Alzrigat, Alba Atienza Párraga, Stefan Enroth, Umashankar Singh, Johanna Ungerstedt, Anders Österborg, Peter J. Brown, Anqi Ma, Jian Jin, Kenneth Nilsson, Fredrik Öberg, Antonia Kalushkova,  and Helena Jernberg-Wiklund
6809-6823
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Down-regulation of C12orf59 is associated with a poor prognosis and VHL mutations in renal cell carcinoma

Down-regulation of C12orf59 is associated with a poor prognosis and VHL mutations in renal cell carcinoma

https://doi.org/10.18632/oncotarget.6829

Jun Xie, Chuangzhi Zhu, Jianting Wu, Cailing Li, Liya Luo, Lingling Xia, Xianxin Li, Yaoting Gui, Zhiming Cai,  and Zesong Li
6824-6834
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Transcriptomic profiling of urine extracellular vesicles reveals alterations of CDH3 in prostate cancer

Transcriptomic profiling of urine extracellular vesicles reveals alterations of CDH3 in prostate cancer

https://doi.org/10.18632/oncotarget.6899

Felix Royo, Patricia Zuñiga-Garcia, Verónica Torrano, Ana Loizaga, Pilar Sanchez-Mosquera, Aitziber Ugalde-Olano, Esperanza González, Ana R. Cortazar, Laura Palomo, Sonia Fernández-Ruiz, Isabel Lacasa-Viscasillas, Maria Berdasco, James D. Sutherland, Rosa Barrio, Amaia Zabala-Letona, Natalia Martín-Martín, Amaia Arruabarrena-Aristorena, Lorea Valcarcel-Jimenez, Alfredo Caro-Maldonado, Jorge Gonzalez-Tampan, Guido Cachi-Fuentes, Manel Esteller, Ana M. Aransay, Miguel Unda, Juan M. Falcón-Pérez,  and Arkaitz Carracedo
6835-6846
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Epigenetic silencing of JMJD5 promotes the proliferation of hepatocellular carcinoma cells by down-regulating the transcription of CDKN1A

Epigenetic silencing of JMJD5 promotes the proliferation of hepatocellular carcinoma cells by down-regulating the transcription of CDKN1A

https://doi.org/10.18632/oncotarget.6867

Bing-Hao Wu, Hui Chen, Chun-Miao Cai, Jia-Zhu Fang, Chong-Chao Wu, Li-Yu Huang, Lan Wang,  and Ze-Guang Han
6847-6863
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Gene amplification during myogenic differentiation

Gene amplification during myogenic differentiation

https://doi.org/10.18632/oncotarget.6845

Ulrike Fischer, Nicole Ludwig, Abdulrahman Raslan, Carola Meier,  and Eckart Meese
6864-6877
Abstract  |  PDF  |  HTML  |  Order a Reprint

Targeted near infrared hyperthermia combined with immune stimulation for optimized therapeutic efficacy in thyroid cancer treatment

Targeted near infrared hyperthermia combined with immune stimulation for optimized therapeutic efficacy in thyroid cancer treatment

https://doi.org/10.18632/oncotarget.6901

Le Zhou, Mengchao Zhang, Qingfeng Fu, Jingting Li,  and Hui Sun
6878-6890
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Decreased expression of B7-H3 reduces the glycolytic capacity and sensitizes breast cancer cells to AKT/mTOR inhibitors

Decreased expression of B7-H3 reduces the glycolytic capacity and sensitizes breast cancer cells to AKT/mTOR inhibitors

https://doi.org/10.18632/oncotarget.6902

Caroline E. Nunes-Xavier, Karine Flem Karlsen, Christina Tekle, Cathrine Pedersen, Tove Øyjord, Vesa Hongisto, Jahn M. Nesland, Ming Tan, Kristine Kleivi Sahlberg,  and Øystein Fodstad
6891-6901
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

R152C DNA Pol β mutation impairs base excision repair and induces cellular transformation

R152C DNA Pol β mutation impairs base excision repair and induces cellular transformation

https://doi.org/10.18632/oncotarget.6849

Ting Zhou, Feiyan Pan, Yan Cao, Ying Han, Jing Zhao, Hongfang Sun, Xiaolong Zhou, Xuping Wu, Lingfeng He, Zhigang Hu, Haoyan Chen, Binghui Shen,  and Zhigang Guo
6902-6915
Abstract  |  PDF  |  HTML  |  Order a Reprint

Human carcinoma-associated mesenchymal stem cells promote ovarian cancer chemotherapy resistance via a BMP4/HH signaling loop

Human carcinoma-associated mesenchymal stem cells promote ovarian cancer chemotherapy resistance via a BMP4/HH signaling loop

https://doi.org/10.18632/oncotarget.6870

Lan G. Coffman, Yun-Jung Choi, Karen McLean, Benjamin L. Allen, Marina Pasca di Magliano,  and Ronald J. Buckanovich
6916-6932
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Nuclear translocation and activation of YAP by hypoxia contributes to the chemoresistance of SN38 in hepatocellular carcinoma cells

Nuclear translocation and activation of YAP by hypoxia contributes to the chemoresistance of SN38 in hepatocellular carcinoma cells

https://doi.org/10.18632/oncotarget.6903

Xiao-Yang Dai, Lin-Han Zhuang, Dan-Dan Wang, Tian-Yi Zhou, Lin-Lin Chang, Ren-Hua Gai, Di-Feng Zhu, Bo Yang, Hong Zhu,  and Qiao-Jun He
6933-6947
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

IRS2 silencing increases apoptosis and potentiates the effects of ruxolitinib in JAK2V617F-positive myeloproliferative neoplasms

IRS2 silencing increases apoptosis and potentiates the effects of ruxolitinib in JAK2V617F-positive myeloproliferative neoplasms

https://doi.org/10.18632/oncotarget.6851

Paula de Melo Campos, João A. Machado-Neto, Christopher A. Eide, Samantha L. Savage, Renata Scopim-Ribeiro, Adriana da Silva Souza Duarte, Patricia Favaro, Irene Lorand-Metze, Fernando F. Costa, Cristina E. Tognon, Brian J. Druker, Sara T. Olalla Saad,  and Fabiola Traina
6948-6959
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

4-Methoxydalbergione suppresses growth and induces apoptosis in human osteosarcoma cells in vitro and in vivo xenograft model through down-regulation of the JAK2/STAT3 pathway

4-Methoxydalbergione suppresses growth and induces apoptosis in human osteosarcoma cells in vitro and in vivo xenograft model through down-regulation of the JAK2/STAT3 pathway

https://doi.org/10.18632/oncotarget.6873

Kyung-Ran Park, Hyung-Mun Yun, Tran-Hong Quang, Hyuncheol Oh, Dong-Sung Lee, Q-Schick Auh,  and Eun-Cheol Kim
6960-6971
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Association of nucleotide excision repair pathway gene polymorphisms with gastric cancer and atrophic gastritis risks

Association of nucleotide excision repair pathway gene polymorphisms with gastric cancer and atrophic gastritis risks

https://doi.org/10.18632/oncotarget.6853

Jingwei Liu, Liping Sun, Qian Xu, Huakang Tu, Caiyun He, Chengzhong Xing,  and Yuan Yuan
6972-6983
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Longitudinal monitoring of EGFR mutations in plasma predicts outcomes of NSCLC patients treated with EGFR TKIs: Korean Lung Cancer Consortium (KLCC-12-02)

Longitudinal monitoring of EGFR mutations in plasma predicts outcomes of NSCLC patients treated with EGFR TKIs: Korean Lung Cancer Consortium (KLCC-12-02)

https://doi.org/10.18632/oncotarget.6874

Ji Yun Lee, Xu Qing, Wei Xiumin, Bai Yali, Sangah Chi, Sojung Hyeon Bak, Ho Yun Lee, Jong-Mu Sun, Se-Hoon Lee, Jin Seok Ahn, Eun Kyung Cho, Dong-Wan Kim, Hye Ryun Kim, Young Joo Min, Sin-Ho Jung, Keunchil Park, Mao Mao,  and Myung-Ju Ahn
6984-6993
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Local 3D matrix confinement determines division axis through cell shape

Local 3D matrix confinement determines division axis through cell shape

https://doi.org/10.18632/oncotarget.5848

Lijuan He, Weitong Chen, Pei-Hsun Wu, Angela Jimenez, Bin Sheng Wong, Angela San, Konstantinos Konstantopoulos,  and Denis Wirtz
6994-7011
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Cdk3-promoted epithelial-mesenchymal transition through activating AP-1 is involved in colorectal cancer metastasis

Cdk3-promoted epithelial-mesenchymal transition through activating AP-1 is involved in colorectal cancer metastasis

https://doi.org/10.18632/oncotarget.6875

Jinping Lu, Zhen Lin Zhang, Damao Huang, Na Tang, Yuejin Li, Zhengke Peng, Chengrong Lu, Zigang Dong,  and Faqing Tang
7012-7028
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Disruption of KIF3A in patient-derived glioblastoma cells: effects on ciliogenesis, hedgehog sensitivity, and tumorigenesis

Disruption of KIF3A in patient-derived glioblastoma cells: effects on ciliogenesis, hedgehog sensitivity, and tumorigenesis

https://doi.org/10.18632/oncotarget.6854

Lan B. Hoang-Minh, Loic P. Deleyrolle, Dorit Siebzehnrubl, George Ugartemendia, Hunter Futch, Benjamin Griffith, Joshua J. Breunig, Gabriel De Leon, Duane A. Mitchell, Susan Semple-Rowland, Brent A. Reynolds,  and Matthew R. Sarkisian
7029-7043
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

miR-493 mediated DKK1 down-regulation confers proliferation, invasion and chemo-resistance in gastric cancer cells

miR-493 mediated DKK1 down-regulation confers proliferation, invasion and chemo-resistance in gastric cancer cells

https://doi.org/10.18632/oncotarget.6951

Xiaoting Jia, Nan Li, Cong Peng, Yingen Deng, Jia Wang, Min Deng, Minying Lu, Jiang Yin, Guopei Zheng, Haiying Liu,  and Zhimin He
7044-7054
Abstract  |  PDF  |  HTML  |  Order a Reprint

STAT3-survivin signaling mediates a poor response to radiotherapy in HER2-positive breast cancers

STAT3-survivin signaling mediates a poor response to radiotherapy in HER2-positive breast cancers

https://doi.org/10.18632/oncotarget.6855

Jae-Sung Kim, Hyun-Ah Kim, Min-Ki Seong, Hyesil Seol, Jeong Su Oh, Eun-Kyu Kim, Jong Wook Chang, Sang-Gu Hwang,  and Woo Chul Noh
7055-7065
Abstract  |  PDF  |  HTML  |  Order a Reprint

Tissue transglutaminase-2 promotes gastric cancer progression via the ERK1/2 pathway

Tissue transglutaminase-2 promotes gastric cancer progression via the ERK1/2 pathway

https://doi.org/10.18632/oncotarget.6883

Xiaofeng Wang, Zhenjia Yu, Quan Zhou, Xiongyan Wu, Xuehua Chen, Jianfang Li, Zhenggang Zhu, Bingya Liu,  and Liping Su
7066-7079
Abstract  |  PDF  |  HTML  |  Order a Reprint

A synthetic lethal screen identifies ATR-inhibition as a novel therapeutic approach for POLD1-deficient cancers

A synthetic lethal screen identifies ATR-inhibition as a novel therapeutic approach for POLD1-deficient cancers

https://doi.org/10.18632/oncotarget.6857

Sandra Hocke, Yang Guo, Albert Job, Michael Orth, Andreas Ziesch, Kirsten Lauber, Enrico N. De Toni, Thomas M. Gress, Andreas Herbst, Burkhard Göke,  and Eike Gallmeier
7080-7095
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Survivin inhibitor YM155 suppresses gastric cancer xenograft growth in mice without affecting normal tissues

Survivin inhibitor YM155 suppresses gastric cancer xenograft growth in mice without affecting normal tissues

https://doi.org/10.18632/oncotarget.6898

Xiao Jiao Cheng, Jia Cheng Lin, Yan Fei Ding, Liming Zhu, Jing Ye,  and Shui Ping Tu
7096-7109
Abstract  |  PDF  |  HTML  |  Order a Reprint

A meta-analysis comparing cisplatin-based to carboplatin-based chemotherapy in moderate to advanced squamous cell carcinoma of head and neck (SCCHN)

A meta-analysis comparing cisplatin-based to carboplatin-based chemotherapy in moderate to advanced squamous cell carcinoma of head and neck (SCCHN)

https://doi.org/10.18632/oncotarget.6858

Jian Guan, Qinyang Li, Yue Zhang, Nanjie Xiao, Min Chen, Yaowei Zhang, Lu Li,  and Longhua Chen
7110-7119
Abstract  |  PDF  |  HTML  |  Order a Reprint

Identifying and functionally characterizing tissue-specific and ubiquitously expressed human lncRNAs

Identifying and functionally characterizing tissue-specific and ubiquitously expressed human lncRNAs

https://doi.org/10.18632/oncotarget.6859

Chunjie Jiang, Yongsheng Li, Zheng Zhao, Jianping Lu, Hong Chen, Na Ding, Guangjuan Wang, Juan Xu,  and Xia Li
7120-7133
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

DYRK1B as therapeutic target in Hedgehog/GLI-dependent cancer cells with Smoothened inhibitor resistance

DYRK1B as therapeutic target in Hedgehog/GLI-dependent cancer cells with Smoothened inhibitor resistance

https://doi.org/10.18632/oncotarget.6910

Wolfgang Gruber, Martin Hutzinger, Dominik Patrick Elmer, Thomas Parigger, Christina Sternberg, Lukasz Cegielkowski, Mirko Zaja, Johann Leban, Susanne Michel, Svetlana Hamm, Daniel Vitt,  and Fritz Aberger
7134-7148
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

miRNA-29a as a tumor suppressor mediates PRIMA-1Met-induced anti-myeloma activity by targeting c-Myc

miRNA-29a as a tumor suppressor mediates PRIMA-1Met-induced anti-myeloma activity by targeting c-Myc

https://doi.org/10.18632/oncotarget.6880

Manujendra N. Saha, Jahangir Abdi, Yijun Yang,  and Hong Chang
7149-7160
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The probiotic Propionibacterium freudenreichii as a new adjuvant for TRAIL-based therapy in colorectal cancer

The probiotic Propionibacterium freudenreichii as a new adjuvant for TRAIL-based therapy in colorectal cancer

https://doi.org/10.18632/oncotarget.6881

Fabien J. Cousin, Sandrine Jouan-Lanhouet, Nathalie Théret, Catherine Brenner, Elodie Jouan, Gwénaëlle Le Moigne-Muller, Marie-Thérèse Dimanche-Boitrel,  and Gwénaël Jan
7161-7178
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

TRAF6 regulates melanoma invasion and metastasis through ubiquitination of Basigin

TRAF6 regulates melanoma invasion and metastasis through ubiquitination of Basigin

https://doi.org/10.18632/oncotarget.6886

Zhongling Luo, Xu Zhang, Weiqi Zeng, Juan Su, Keda Yang, Lixia Lu, Chuan Bian Lim, Wen Tang, Lisha Wu, Shuang Zhao, Xuekun Jia, Cong Peng,  and Xiang Chen
7179-7192
Abstract  |  PDF  |  HTML  |  Order a Reprint

DANGER is involved in high glucose-induced radioresistance through inhibiting DAPK-mediated anoikis in non-small cell lung cancer

DANGER is involved in high glucose-induced radioresistance through inhibiting DAPK-mediated anoikis in non-small cell lung cancer

https://doi.org/10.18632/oncotarget.6887

TaeWoo Kwon, HyeSook Youn, Beomseok Son, Daehoon Kim, Ki Moon Seong, Sungkyun Park, Wanyeon Kim,  and BuHyun Youn
7193-7206
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MRP3 as a novel resistance factor for sorafenib in hepatocellular carcinoma

MRP3 as a novel resistance factor for sorafenib in hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.6889

Tetsu Tomonari, Shunsaku Takeishi, Tatsuya Taniguchi, Takahiro Tanaka, Hironori Tanaka, Shota Fujimoto, Tetsuo Kimura, Koichi Okamoto, Hiroshi Miyamoto, Naoki Muguruma,  and Tetsuji Takayama
7207-7215
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Metabonomic analysis of ovarian tumour cyst fluid by proton nuclear magnetic resonance spectroscopy

Metabonomic analysis of ovarian tumour cyst fluid by proton nuclear magnetic resonance spectroscopy

https://doi.org/10.18632/oncotarget.6891

Michael Kyriakides, Nona Rama, Jasmin Sidhu, Hani Gabra, Hector C. Keun,  and Mona El-Bahrawy
7216-7226
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Prognostic value of tumor-infiltrating lymphocytes for patients with completely resected stage IIIA(N2) non-small cell lung cancer

Prognostic value of tumor-infiltrating lymphocytes for patients with completely resected stage IIIA(N2) non-small cell lung cancer

https://doi.org/10.18632/oncotarget.6979

Wen Feng, Yuan Li, Lei Shen, Xu-Wei Cai, Zheng-Fei Zhu, Jian-Hua Chang, Jia-Qing Xiang, Ya-Wei Zhang, Hai-Quan Chen,  and Xiao-Long Fu
7227-7240
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Tumor vascularity and lipiodol deposition as early radiological markers for predicting risk of disease progression in patients with unresectable hepatocellular carcinoma after transarterial chemoembolization

Tumor vascularity and lipiodol deposition as early radiological markers for predicting risk of disease progression in patients with unresectable hepatocellular carcinoma after transarterial chemoembolization

https://doi.org/10.18632/oncotarget.6892

Cheng-Shi Chen, Fang-Kun Li, Chen-Yang Guo, Jin-Cheng Xiao, Hong-Tao Hu, Hong-Tao Cheng, Lin Zheng, Deng-Wei Zong, Jun-Li Ma, Li Jiang,  and Hai-Liang Li
7241-7252
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A novel nuclear Src and p300 signaling axis controls migratory and invasive behavior in pancreatic cancer

A novel nuclear Src and p300 signaling axis controls migratory and invasive behavior in pancreatic cancer

https://doi.org/10.18632/oncotarget.6635

David Paladino, Peibin Yue, Hideki Furuya, Jared Acoba, Charles J. Rosser,  and James Turkson
7253-7267
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Artemisinin-derived dimer ART-838 potently inhibited human acute leukemias, persisted in vivo, and synergized with antileukemic drugs

Artemisinin-derived dimer ART-838 potently inhibited human acute leukemias, persisted in vivo, and synergized with antileukemic drugs

https://doi.org/10.18632/oncotarget.6896

Jennifer M. Fox, James R. Moynihan, Bryan T. Mott, Jennifer R. Mazzone, Nicole M. Anders, Patrick A. Brown, Michelle A. Rudek, Jun O. Liu, Ravit Arav-Boger, Gary H. Posner, Curt I. Civin,  and Xiaochun Chen
7268-7279
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

CXCR2 signaling regulates KRAS(G12D)-induced autocrine growth of pancreatic cancer

CXCR2 signaling regulates KRAS(G12D)-induced autocrine growth of pancreatic cancer

https://doi.org/10.18632/oncotarget.6906

Abhilasha Purohit, Michelle Varney, Satyanarayana Rachagani, Michel M. Ouellette, Surinder K. Batra,  and Rakesh K. Singh
7280-7296
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Acyl protein thioesterase 1 and 2 (APT-1, APT-2) inhibitors palmostatin B, ML348 and ML349 have different effects on NRAS mutant melanoma cells

Acyl protein thioesterase 1 and 2 (APT-1, APT-2) inhibitors palmostatin B, ML348 and ML349 have different effects on NRAS mutant melanoma cells

https://doi.org/10.18632/oncotarget.6907

Igor Vujic, Martina Sanlorenzo, Rosaura Esteve-Puig, Marin Vujic, Andrew Kwong, Aaron Tsumura, Ryan Murphy, Adrian Moy, Christian Posch, Babak Monshi, Klemens Rappersberger,  and Susana Ortiz-Urda
7297-7306
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

IL-32θ inhibits stemness and epithelial-mesenchymal transition of cancer stem cells via the STAT3 pathway in colon cancer

IL-32θ inhibits stemness and epithelial-mesenchymal transition of cancer stem cells via the STAT3 pathway in colon cancer

https://doi.org/10.18632/oncotarget.7007

Yesol Bak, Taeho Kwon, In seon Bak, Jintae Hong, Dae-Yeul Yu,  and Do-Young Yoon
7307-7317
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Anti-ovarian tumor response of donor peripheral blood mononuclear cells is due to infiltrating cytotoxic NK cells

Anti-ovarian tumor response of donor peripheral blood mononuclear cells is due to infiltrating cytotoxic NK cells

https://doi.org/10.18632/oncotarget.6939

Veethika Pandey, Jeremiah L. Oyer, Robert Y. Igarashi, Sarah B. Gitto, Alicja J. Copik,  and Deborah A. Altomare
7318-7328
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Crosstalk between ATF4 and MTA1/HDAC1 promotes osteosarcoma progression

Crosstalk between ATF4 and MTA1/HDAC1 promotes osteosarcoma progression

https://doi.org/10.18632/oncotarget.6940

Heng Zeng, Jin-ming Zhang, Yu Du, Jiang Wang, Ye Ren, Mi Li, Hao Li, Zhuo Cai, Qian Chu,  and Caihong Yang
7329-7342
Abstract  |  PDF  |  HTML  |  Order a Reprint

CXCR6-CXCL16 axis promotes prostate cancer by mediating cytoskeleton rearrangement via Ezrin activation and αvβ3 integrin clustering

CXCR6-CXCL16 axis promotes prostate cancer by mediating cytoskeleton rearrangement via Ezrin activation and αvβ3 integrin clustering

https://doi.org/10.18632/oncotarget.6944

Rajesh Singh, Neeraj Kapur, Hina Mir, Nalinaksha Singh, James W. Lillard Jr.,  and Shailesh Singh
7343-7353
Abstract  |  PDF  |  HTML  |  Order a Reprint

Comparison of liver oncogenic potential among human RAS isoforms

Comparison of liver oncogenic potential among human RAS isoforms

https://doi.org/10.18632/oncotarget.6931

Sook In Chung, Hyuk Moon, Hye-Lim Ju, Dae Yeong Kim, Kyung Joo Cho, Silvia Ribback, Frank Dombrowski, Diego F. Calvisi,  and Simon Weonsang Ro
7354-7366
Abstract  |  PDF  |  HTML  |  Order a Reprint

Corrections

Correction: Noncanonical roles of membranous lysyl-tRNA synthetase in transducing cell-substrate signaling for invasive dissemination of colon cancer spheroids in 3D collagen I gels

Correction: Noncanonical roles of membranous lysyl-tRNA synthetase in transducing cell-substrate signaling for invasive dissemination of colon cancer spheroids in 3D collagen I gels

https://doi.org/10.18632/oncotarget.7117

Seo Hee Nam, Doyeun Kim, Mi-Sook Lee, Doohyung Lee, Tae Kyoung Kwak, Minkyung Kang, Jihye Ryu, Hye-Jin Kim, Haeng Eun Song, Jungeun Choi, Gyu-Ho Lee, Sang-Yeob Kim, Song Hwa Park, Dae Gyu Kim, Nam Hoon Kwon, Tai Young Kim, Jean Paul Thiery, Sunghoon Kim,  and Jung Weon Lee
7367-7367
Correction  |  PDF


Copyright © 2017 Impact Journals
Impact Journals is a registered trademark of Impact Journals, LLC