Oncotarget

Vol 7, No 4

January 26, 2016

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About The Cover

A Multiplexed Marker-based Algorithm for Diagnosis of Carcinoma of Unknown Primary Using Circulating Tumor Cells. See Matthew et al.

Table of Contents

Research Perspectives

Blocking the survival of the nastiest by HSP90 inhibition

Blocking the survival of the nastiest by HSP90 inhibition

https://doi.org/10.18632/oncotarget.6971

Paul Workman, Paul A. Clarke,  and Bissan Al-Lazikani
3658-3661
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Priority Research Papers

A multiplexed marker-based algorithm for diagnosis of carcinoma of unknown primary using circulating tumor cells

A multiplexed marker-based algorithm for diagnosis of carcinoma of unknown primary using circulating tumor cells

https://doi.org/10.18632/oncotarget.6657

Elizabeth M. Matthew, Lanlan Zhou, Zhaohai Yang, David T. Dicker, Sheldon L. Holder, Bora Lim, Ramdane Harouaka, Si-Yang Zheng, Joseph J. Drabick, Nicholas E. Lamparella, Cristina I. Truica,  and Wafik S. El-Deiry
3662-3676
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SHIP represses lung inflammation and inhibits mammary tumor metastasis in BALB/c mice

SHIP represses lung inflammation and inhibits mammary tumor metastasis in BALB/c mice

https://doi.org/10.18632/oncotarget.6611

Melisa J. Hamilton, Elizabeth C. Halvorsen, Nancy E. LePard, Momir Bosiljcic, Victor W. Ho, Vivian Lam, Judit Banáth, Kevin L. Bennewith,  and Gerald Krystal
3677-3691
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Research Papers: Gerotarget (Focus on Aging)

Core level regulatory network of osteoblast as molecular mechanism for osteoporosis and treatment

Core level regulatory network of osteoblast as molecular mechanism for osteoporosis and treatment

https://doi.org/10.18632/oncotarget.6923

Ruoshi Yuan, Shengfei Ma, Xiaomei Zhu, Jun Li, Yuhong Liang, Tao Liu, Yanxia Zhu, Bingbing Zhang, Shuang Tan, Huajie Guo, Shuguang Guan, Ping Ao,  and Guangqian Zhou
3692-3701
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Research Papers: Immunology

Alpha-fetoprotein still is a valuable diagnostic and prognosis predicting biomarker in hepatitis B virus infection-related hepatocellular carcinoma

Alpha-fetoprotein still is a valuable diagnostic and prognosis predicting biomarker in hepatitis B virus infection-related hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.6913

Mingjie Yao, Jingmin Zhao,  and Fengmin Lu
3702-3708
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Research Papers: Autophagy and Cell Death

Cooperative TRAIL production mediates IFNα/Smac mimetic-induced cell death in TNFα-resistant solid cancer cells

Cooperative TRAIL production mediates IFNα/Smac mimetic-induced cell death in TNFα-resistant solid cancer cells

https://doi.org/10.18632/oncotarget.6915

Stefanie Roesler, Ines Eckhardt, Sebastian Wolf,  and Simone Fulda
3709-3725
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Research Papers: Chromosome

DNA demethylation caused by 5-Aza-2’-deoxycytidine induces mitotic alterations and aneuploidy

DNA demethylation caused by 5-Aza-2’-deoxycytidine induces mitotic alterations and aneuploidy

https://doi.org/10.18632/oncotarget.6897

Giuseppe Costa, Viviana Barra, Laura Lentini, Danilo Cilluffo,  and Aldo Di Leonardo
3726-3739
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Reviews

Leptomeningeal metastasis in breast cancer – a systematic review

Leptomeningeal metastasis in breast cancer – a systematic review

https://doi.org/10.18632/oncotarget.5911

Brian J. Scott, Nancy A. Oberheim-Bush,  and Santosh Kesari
3740-3747
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The role of the oncofetal H19 lncRNA in tumor metastasis: orchestrating the EMT-MET decision

The role of the oncofetal H19 lncRNA in tumor metastasis: orchestrating the EMT-MET decision

https://doi.org/10.18632/oncotarget.6387

Imad J. Matouk, David Halle, Eli Raveh, Michal Gilon, Vladimir Sorin,  and Avraham Hochberg
3748-3765
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DAB2IP in cancer

DAB2IP in cancer

https://doi.org/10.18632/oncotarget.6501

Liang Liu, Cong Xu, Jer-Tsong Hsieh, Jianping Gong,  and Daxing Xie
3766-3776
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Research Papers

Leukemia inhibitory factor promotes EMT through STAT3-dependent miR-21 induction

Leukemia inhibitory factor promotes EMT through STAT3-dependent miR-21 induction

https://doi.org/10.18632/oncotarget.6756

Xuetian Yue, Yuhan Zhao, Cen Zhang, Jun Li, Zhen Liu, Juan Liu,  and Wenwei Hu
3777-3790
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Overexpressed CISD2 has prognostic value in human gastric cancer and promotes gastric cancer cell proliferation and tumorigenesis via AKT signaling pathway

Overexpressed CISD2 has prognostic value in human gastric cancer and promotes gastric cancer cell proliferation and tumorigenesis via AKT signaling pathway

https://doi.org/10.18632/oncotarget.6302

Lan Wang, Fei Ouyang, Xiaobo Liu, Shu Wu, Hong-mei Wu, Yuandong Xu, Bin Wang, Jinrong Zhu, Xuehu Xu,  and Liang Zhang
3791-3805
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CD147 and downstream ADAMTSs promote the tumorigenicity of Kaposi’s sarcoma-associated herpesvirus infected endothelial cells

CD147 and downstream ADAMTSs promote the tumorigenicity of Kaposi’s sarcoma-associated herpesvirus infected endothelial cells

https://doi.org/10.18632/oncotarget.6584

Lu Dai, Jimena Trillo-Tinoco, Yihan Chen, Karlie Bonstaff, Luis Del Valle, Chris Parsons, Augusto C. Ochoa, Jovanny Zabaleta, Bryan P. Toole,  and Zhiqiang Qin
3806-3818
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The pentacyclic triterpenoid, plectranthoic acid, a novel activator of AMPK induces apoptotic death in prostate cancer cells

The pentacyclic triterpenoid, plectranthoic acid, a novel activator of AMPK induces apoptotic death in prostate cancer cells

https://doi.org/10.18632/oncotarget.6625

Nosheen Akhtar, Deeba N. Syed, Mohammad Imran Khan, Vaqar M. Adhami, Bushra Mirza,  and Hasan Mukhtar
3819-3831
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Carnitine palmitoyltransferase 1A functions to repress FoxO transcription factors to allow cell cycle progression in ovarian cancer

Carnitine palmitoyltransferase 1A functions to repress FoxO transcription factors to allow cell cycle progression in ovarian cancer

https://doi.org/10.18632/oncotarget.6757

Huanjie Shao, Esraa M. Mohamed, Guoyan G. Xu, Michael Waters, Kai Jing, Yibao Ma, Yan Zhang, Sarah Spiegel, Michael O. Idowu,  and Xianjun Fang
3832-3846
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High efficacy of third generation EGFR inhibitor AZD9291 in a leptomeningeal carcinomatosis model with EGFR-mutant lung cancer cells

High efficacy of third generation EGFR inhibitor AZD9291 in a leptomeningeal carcinomatosis model with EGFR-mutant lung cancer cells

https://doi.org/10.18632/oncotarget.6758

Shigeki Nanjo, Hiromichi Ebi, Sachiko Arai, Shinji Takeuchi, Tadaaki Yamada, Satsuki Mochizuki, Yasunori Okada, Mitsutoshi Nakada, Takashi Murakami,  and Seiji Yano
3847-3856
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Signature miRNAs in colorectal cancers were revealed using a bias reduction small RNA deep sequencing protocol

Signature miRNAs in colorectal cancers were revealed using a bias reduction small RNA deep sequencing protocol

https://doi.org/10.18632/oncotarget.6460

Guihua Sun, Ya-Wen Cheng, Lily Lai, Tsui-Chin Huang, Jinhui Wang, Xiwei Wu, Yafan Wang, Yasheng Huang, Jinghan Wang, Keqiang Zhang, Shuya Hu, Ji-Rui Yang,  and Yun Yen
3857-3872
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Identification of H7 as a novel peroxiredoxin I inhibitor to induce differentiation of leukemia cells

Identification of H7 as a novel peroxiredoxin I inhibitor to induce differentiation of leukemia cells

https://doi.org/10.18632/oncotarget.6763

Wei Wei, Chunmin Ma, Yang Cao, Li Yang, Zhimin Huang, Dongjun Qin, Yingyi Chen, Chuanxu Liu, Li Xia, Tongdan Wang, Hu Lei, Yun Yu, Min Huang, Yin Tong, Hanzhang Xu, Fenghou Gao, Jian Zhang,  and Ying-Li Wu
3873-3883
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Overexpression of wildtype EGFR is tumorigenic and denotes a therapeutic target in non-small cell lung cancer

Overexpression of wildtype EGFR is tumorigenic and denotes a therapeutic target in non-small cell lung cancer

https://doi.org/10.18632/oncotarget.6461

Naiqing Xu, Wenfeng Fang, Libing Mu, Yanna Tang, Lei Gao, Shengxiang Ren, Dengfeng Cao, Lixin Zhou, Aiqun Zhang, Deruo Liu, Caicun Zhou, Kwok-Kin Wong, Lei Yu, Li Zhang,  and Liang Chen
3884-3896
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Heterogeneity and chronology of 6q15 deletion and ERG-fusion in prostate cancer

Heterogeneity and chronology of 6q15 deletion and ERG-fusion in prostate cancer

https://doi.org/10.18632/oncotarget.6597

Martina Kluth, David Meyer, Antje Krohn, Fabian Freudenthaler, Melanie Bauer, Georg Salomon, Hans Heinzer, Uwe Michl, Stefan Steurer, Ronald Simon, Guido Sauter, Thorsten Schlomm,  and Sarah Minner
3897-3904
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Genetic deletion of osteopontin in TRAMP mice skews prostate carcinogenesis from adenocarcinoma to aggressive human-like neuroendocrine cancers

Genetic deletion of osteopontin in TRAMP mice skews prostate carcinogenesis from adenocarcinoma to aggressive human-like neuroendocrine cancers

https://doi.org/10.18632/oncotarget.6678

Giorgio Mauri, Elena Jachetti, Barbara Comuzzi, Matteo Dugo, Ivano Arioli, Silvia Miotti, Sabina Sangaletti, Emma Di Carlo, Claudio Tripodo,  and Mario P. Colombo
3905-3920
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Up-regulation of REG3A in colorectal cancer cells confers proliferation and correlates with colorectal cancer risk

Up-regulation of REG3A in colorectal cancer cells confers proliferation and correlates with colorectal cancer risk

https://doi.org/10.18632/oncotarget.6473

Ying Ye, Ling Xiao, Su-Juan Wang, Wei Yue, Qiao-Shan Yin, Meng-Yao Sun, Wei Xia, Zhi-Yi Shao,  and Hong Zhang
3921-3933
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Targeting a novel domain in podoplanin for inhibiting platelet-mediated tumor metastasis

Targeting a novel domain in podoplanin for inhibiting platelet-mediated tumor metastasis

https://doi.org/10.18632/oncotarget.6598

Takaya Sekiguchi, Ai Takemoto, Satoshi Takagi, Kazuki Takatori, Shigeo Sato, Miho Takami,  and Naoya Fujita
3934-3946
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Primary cross-resistance to BRAFV600E-, MEK1/2- and PI3K/mTOR-specific inhibitors in BRAF-mutant melanoma cells counteracted by dual pathway blockade

Primary cross-resistance to BRAFV600E-, MEK1/2- and PI3K/mTOR-specific inhibitors in BRAF-mutant melanoma cells counteracted by dual pathway blockade

https://doi.org/10.18632/oncotarget.6600

Ilaria Penna, Alessandra Molla, Giulia Grazia, Loredana Cleris, Gabriella Nicolini, Federica Perrone, Benedetta Picciani, Michele Del Vecchio, Filippo de Braud, Roberta Mortarini,  and Andrea Anichini
3947-3965
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Reduced expression of SET7/9, a histone mono-methyltransferase, is associated with gastric cancer progression

Reduced expression of SET7/9, a histone mono-methyltransferase, is associated with gastric cancer progression

https://doi.org/10.18632/oncotarget.6681

Yoshimitsu Akiyama, Yuki Koda, Sun-ju Byeon, Shu Shimada, Taketo Nishikawaji, Ayuna Sakamoto, Yingxuan Chen, Kazuyuki Kojima, Tatsuyuki Kawano, Yoshinobu Eishi, Dajun Deng, Woo Ho Kim, Wei-Guo Zhu, Yasuhito Yuasa,  and Shinji Tanaka
3966-3983
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Simultaneous gene silencing of KRAS and anti-apoptotic genes as a multitarget therapy

Simultaneous gene silencing of KRAS and anti-apoptotic genes as a multitarget therapy

https://doi.org/10.18632/oncotarget.6766

Kristin Werner, Franziska Lademann, May-Linn Thepkaysone, Beatrix Jahnke, Daniela E. Aust, Christoph Kahlert, Georg Weber, Jürgen Weitz, Robert Grützmann,  and Christian Pilarsky
3984-3992
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Exosomes from bulk and stem cells from human prostate cancer have a differential microRNA content that contributes cooperatively over local and pre-metastatic niche

Exosomes from bulk and stem cells from human prostate cancer have a differential microRNA content that contributes cooperatively over local and pre-metastatic niche

https://doi.org/10.18632/oncotarget.6540

Catherine A. Sánchez, Eliana I. Andahur, Rodrigo Valenzuela, Enrique A. Castellón, Juan A. Fullá, Christian G. Ramos,  and Juan C. Triviño
3993-4008
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miR-30a inhibits endothelin A receptor and chemoresistance in ovarian carcinoma

miR-30a inhibits endothelin A receptor and chemoresistance in ovarian carcinoma

https://doi.org/10.18632/oncotarget.6546

Rosanna Sestito, Roberta Cianfrocca, Laura Rosanò, Piera Tocci, Elisa Semprucci, Valeriana Di Castro, Valentina Caprara, Gabriella Ferrandina, Andrea Sacconi, Giovanni Blandino,  and Anna Bagnato
4009-4023
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Identification of the BRAF V600E mutation in gastroenteropancreatic neuroendocrine tumors

Identification of the BRAF V600E mutation in gastroenteropancreatic neuroendocrine tumors

https://doi.org/10.18632/oncotarget.6602

Charny Park, Sang Yun Ha, Seung Tae Kim, Hee Cheol Kim, Jin Seok Heo, Young Suk Park, Gregory Lauwers, Jeeyun Lee,  and Kyoung-Mee Kim
4024-4035
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Periostin in tumor microenvironment is associated with poor prognosis and platinum resistance in epithelial ovarian carcinoma

Periostin in tumor microenvironment is associated with poor prognosis and platinum resistance in epithelial ovarian carcinoma

https://doi.org/10.18632/oncotarget.6700

Pi-Lin Sung, Yi-Hua Jan, Shih-Chieh Lin, Chao-Cheng Huang, Hao Lin, Kuo-Chang Wen, Kuan-Chong Chao, Chiung-Ru Lai, Peng-Hui Wang, Chi-Mu Chuang, Hua-Hsi Wu, Nae-Fang Twu, Ming-Shyen Yen, Michael Hsiao,  and Chi-Ying F. Huang
4036-4047
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Enhanced expression of LINE-1-encoded ORF2 protein in early stages of colon and prostate transformation

Enhanced expression of LINE-1-encoded ORF2 protein in early stages of colon and prostate transformation

https://doi.org/10.18632/oncotarget.6767

Chiara De Luca, Fiorella Guadagni, Paola Sinibaldi-Vallebona, Steno Sentinelli, Michele Gallucci, Andreas Hoffmann, Gerald G. Schumann, Corrado Spadafora,  and Ilaria Sciamanna
4048-4061
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Inhibiting the anaphase promoting complex/cyclosome induces a metaphase arrest and cell death in multiple myeloma cells

Inhibiting the anaphase promoting complex/cyclosome induces a metaphase arrest and cell death in multiple myeloma cells

https://doi.org/10.18632/oncotarget.6768

Susanne Lub, Anke Maes, Ken Maes, Kim De Veirman, Elke De Bruyne, Eline Menu, Karel Fostier, Alboukadel Kassambara, Jérôme Moreaux, Dirk Hose, Xavier Leleu, Randall W. King, Karin Vanderkerken,  and Els Van Valckenborgh
4062-4076
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Liposome armed with herpes virus-derived gH625 peptide to overcome doxorubicin resistance in lung adenocarcinoma cell lines

Liposome armed with herpes virus-derived gH625 peptide to overcome doxorubicin resistance in lung adenocarcinoma cell lines

https://doi.org/10.18632/oncotarget.6013

Emiliana Perillo, Stefania Porto, Annarita Falanga, Silvia Zappavigna, Paola Stiuso, Virginia Tirino, Vincenzo Desiderio, Gianpaolo Papaccio, Massimiliano Galdiero, Antonio Giordano, Stefania Galdiero,  and Michele Caraglia
4077-4092
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Significant blockade of multiple receptor tyrosine kinases by MGCD516 (Sitravatinib), a novel small molecule inhibitor, shows potent anti-tumor activity in preclinical models of sarcoma

Significant blockade of multiple receptor tyrosine kinases by MGCD516 (Sitravatinib), a novel small molecule inhibitor, shows potent anti-tumor activity in preclinical models of sarcoma

https://doi.org/10.18632/oncotarget.6547

Parag P. Patwardhan, Kathryn S. Ivy, Elgilda Musi, Elisa de Stanchina,  and Gary K. Schwartz
4093-4109
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Loss of E-cadherin disrupts ovarian epithelial inclusion cyst formation and collective cell movement in ovarian cancer cells

Loss of E-cadherin disrupts ovarian epithelial inclusion cyst formation and collective cell movement in ovarian cancer cells

https://doi.org/10.18632/oncotarget.6588

Pui-Wah Choi, Junzheng Yang, Shu-Kay Ng, Colleen Feltmate, Michael G. Muto, Kathleen Hasselblatt, Kyle Lafferty-Whyte, Lellean JeBailey, Laura MacConaill, William R. Welch, Wing-Ping Fong, Ross S. Berkowitz,  and Shu-Wing Ng
4110-4121
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Autophagy is involved in TGF-β1-induced protective mechanisms and formation of cancer-associated fibroblasts phenotype in tumor microenvironment

Autophagy is involved in TGF-β1-induced protective mechanisms and formation of cancer-associated fibroblasts phenotype in tumor microenvironment

https://doi.org/10.18632/oncotarget.6702

Fang-Lan Liu, En-Pan Mo, Liu Yang, Jun Du, Hong-Sheng Wang, Huan Zhang, Hiroshi Kurihara, Jun Xu,  and Shao-Hui Cai
4122-4141
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Combination therapy of RY10-4 with the γ-secretase inhibitor DAPT shows promise in treating HER2-amplified breast cancer

Combination therapy of RY10-4 with the γ-secretase inhibitor DAPT shows promise in treating HER2-amplified breast cancer

https://doi.org/10.18632/oncotarget.6769

Feng Su, Shilin Zhu, Jinlan Ruan, Yagmur Muftuoglu, Longbo Zhang,  and Qianying Yuan
4142-4154
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Lack of survival advantage with autologous stem-cell transplantation in high-risk neuroblastoma consolidated by anti-GD2 immunotherapy and isotretinoin

Lack of survival advantage with autologous stem-cell transplantation in high-risk neuroblastoma consolidated by anti-GD2 immunotherapy and isotretinoin

https://doi.org/10.18632/oncotarget.6393

Brian H. Kushner, Irina Ostrovnaya, Irene Y. Cheung, Deborah Kuk, Shakeel Modak, Kim Kramer, Stephen S. Roberts, Ellen M. Basu, Karima Yataghene,  and Nai-Kong V. Cheung
4155-4166
Abstract  |  PDF  |  HTML  |  Order a Reprint

Sphingosine kinase 1 is required for TGF-β mediated fibroblastto- myofibroblast differentiation in ovarian cancer

Sphingosine kinase 1 is required for TGF-β mediated fibroblastto- myofibroblast differentiation in ovarian cancer

https://doi.org/10.18632/oncotarget.6703

Jessica A. Beach, Paul-Joseph P. Aspuria, Dong-Joo Cheon, Kate Lawrenson, Hasmik Agadjanian, Christine S. Walsh, Beth Y. Karlan,  and Sandra Orsulic
4167-4182
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The prognostic role of desmoplastic stroma in pancreatic ductal adenocarcinoma

The prognostic role of desmoplastic stroma in pancreatic ductal adenocarcinoma

https://doi.org/10.18632/oncotarget.6770

Lai Mun Wang, Michael A. Silva, Zenobia D’Costa, Robin Bockelmann, Zahir Soonawalla, Stanley Liu, Eric O’Neill, Somnath Mukherjee, W. Gillies McKenna, Ruth Muschel,  and Emmanouil Fokas
4183-4194
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Epigenetic modification of TLR4 promotes activation of NF-κB by regulating methyl-CpG-binding domain protein 2 and Sp1 in gastric cancer

Epigenetic modification of TLR4 promotes activation of NF-κB by regulating methyl-CpG-binding domain protein 2 and Sp1 in gastric cancer

https://doi.org/10.18632/oncotarget.6549

Tae Woo Kim, Seon-Jin Lee, Byung Moo Oh, Heesoo Lee, Tae Gi Uhm, Jeong-Ki Min, Young-Jun Park, Suk Ran Yoon, Bo-Yeon Kim, Jong Wan Kim, Yong-Kyung Choe,  and Hee Gu Lee
4195-4209
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Clinical implication of voltage-dependent anion channel 1 in uterine cervical cancer and its action on cervical cancer cells

Clinical implication of voltage-dependent anion channel 1 in uterine cervical cancer and its action on cervical cancer cells

https://doi.org/10.18632/oncotarget.6704

Chih-Hsien Wu, Yu-Wen Lin, Tzu-Fan Wu, Jiunn-Liang Ko,  and Po-Hui Wang
4210-4225
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Overexpressed EDIL3 predicts poor prognosis and promotes anchorage-independent tumor growth in human pancreatic cancer

Overexpressed EDIL3 predicts poor prognosis and promotes anchorage-independent tumor growth in human pancreatic cancer

https://doi.org/10.18632/oncotarget.6772

Shu-Heng Jiang, Yang Wang, Jian-Yu Yang, Jun Li, Ming-Xuan Feng, Ya-Hui Wang, Xiao-Mei Yang, Ping He, Guang-Ang Tian, Xiao-Xin Zhang, Qing Li, Xiao-Yan Cao, Yan-Miao Huo, Min-Wei Yang, Xue-Liang Fu, Jiao Li, De-Jun Liu, Miao Dai, Shan-Yun Wen, Jian-Ren Gu, Jie Hong, Rong Hua, Zhi-Gang Zhang,  and Yong-Wei Sun
4226-4240
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Recurrent AKT mutations in human cancers: functional consequences and effects on drug sensitivity

Recurrent AKT mutations in human cancers: functional consequences and effects on drug sensitivity

https://doi.org/10.18632/oncotarget.6648

Kyung H. Yi,  and Josh Lauring
4241-4251
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Upregulation of flotillin-1 promotes invasion and metastasis by activating TGF-β signaling in nasopharyngeal carcinoma

Upregulation of flotillin-1 promotes invasion and metastasis by activating TGF-β signaling in nasopharyngeal carcinoma

https://doi.org/10.18632/oncotarget.6483

Sumei Cao, Yanmei Cui, Huiming Xiao, Miaoqing Mai, Chanjuan Wang, Shanghang Xie, Jing Yang, Shu Wu, Jun Li, Libing Song, Xiang Guo,  and Chuyong Lin
4252-4264
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Metformin increases antitumor activity of MEK inhibitors through GLI1 downregulation in LKB1 positive human NSCLC cancer cells

Metformin increases antitumor activity of MEK inhibitors through GLI1 downregulation in LKB1 positive human NSCLC cancer cells

https://doi.org/10.18632/oncotarget.6559

Carminia Maria Della Corte, Vincenza Ciaramella, Concetta Di Mauro, Maria Domenica Castellone, Federica Papaccio, Morena Fasano, Ferdinando Carlo Sasso, Erika Martinelli, Teresa Troiani, Ferdinando De Vita, Michele Orditura, Roberto Bianco, Fortunato Ciardiello,  and Floriana Morgillo
4265-4278
Abstract  |  PDF  |  HTML  |  Order a Reprint

RASSF10 is an epigenetically inactivated tumor suppressor and independent prognostic factor in hepatocellular carcinoma

RASSF10 is an epigenetically inactivated tumor suppressor and independent prognostic factor in hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.6654

Fei Wang, Ying Feng, Peng Li, Kun Wang, Liang Feng, Yi-Fei Liu, Hua Huang, Yi-Bing Guo, Qin-Sheng Mao,  and Wan-Jiang Xue
4279-4297
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Identification of ovarian cancer subtype-specific network modules and candidate drivers through an integrative genomics approach

Identification of ovarian cancer subtype-specific network modules and candidate drivers through an integrative genomics approach

https://doi.org/10.18632/oncotarget.6774

Di Zhang, Peng Chen, Chun-Hou Zheng,  and Junfeng Xia
4298-4309
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

CCL3 promotes angiogenesis by dysregulation of miR-374b/ VEGF-A axis in human osteosarcoma cells

CCL3 promotes angiogenesis by dysregulation of miR-374b/ VEGF-A axis in human osteosarcoma cells

https://doi.org/10.18632/oncotarget.6708

Yuan-Ya Liao, Hsiao-Chi Tsai, Pei-Yu Chou, Shih-Wei Wang, Hsien-Te Chen, Yu-Min Lin, I-Ping Chiang, Tzu-Ming Chang, Shao-Keh Hsu, Ming-Chih Chou, Chih-Hsin Tang,  and Yi-Chin Fong
4310-4325
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Reactivation of wild-type and mutant p53 by tryptophanolderived oxazoloisoindolinone SLMP53-1, a novel anticancer small-molecule

Reactivation of wild-type and mutant p53 by tryptophanolderived oxazoloisoindolinone SLMP53-1, a novel anticancer small-molecule

https://doi.org/10.18632/oncotarget.6775

Joana Soares, Liliana Raimundo, Nuno A.L. Pereira, Ângelo Monteiro, Sara Gomes, Cláudia Bessa, Clara Pereira, Glória Queiroz, Alessandra Bisio, João Fernandes, Célia Gomes, Flávio Reis, Jorge Gonçalves, Alberto Inga, Maria M.M. Santos,  and Lucília Saraiva
4326-4343
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

WWOX modulates the ATR-mediated DNA damage checkpoint response

WWOX modulates the ATR-mediated DNA damage checkpoint response

https://doi.org/10.18632/oncotarget.6571

Mohammad Abu-Odeh, Nyla A. Hereema,  and Rami I. Aqeilan
4344-4355
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Niacin alleviates TRAIL-mediated colon cancer cell death via autophagy flux activation

Niacin alleviates TRAIL-mediated colon cancer cell death via autophagy flux activation

https://doi.org/10.18632/oncotarget.5374

Sung-Wook Kim, Ju-Hee Lee, Ji-Hong Moon, Uddin M.D. Nazim, You-Jin Lee, Jae-Won Seol, Jin Hur, Seong-Kug Eo, John-Hwa Lee,  and Sang-Youel Park
4356-4368
Abstract  |  PDF  |  HTML  |  Order a Reprint

Adenovirus-mediated delivery of herpes simplex virus thymidine kinase administration improves outcome of recurrent high-grade glioma

Adenovirus-mediated delivery of herpes simplex virus thymidine kinase administration improves outcome of recurrent high-grade glioma

https://doi.org/10.18632/oncotarget.6737

Nan Ji, Danhui Weng, Cang Liu, Zheng Gu, Shizhang Chen, Ying Guo, Zhong Fan, Xiao Wang, Jianfei Chen, Yanyan Zhao, Jianfeng Zhou, Jisheng Wang, Ding Ma,  and Ning Li
4369-4378
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Effect of pravastatin on the survival of patients with advanced gastric cancer

Effect of pravastatin on the survival of patients with advanced gastric cancer

https://doi.org/10.18632/oncotarget.6777

Luis Bujanda, Araceli Rodríguez-González, Cristina Sarasqueta, Emma Eizaguirre, Elizabeth Hijona, José J.G. Marín, María J. Perugorria, Jesús M. Banales,  and Angel Cosme
4379-4384
Abstract  |  PDF  |  HTML  |  Order a Reprint

Liver irradiation causes distal bystander effects in the rat brain and affects animal behaviour

Liver irradiation causes distal bystander effects in the rat brain and affects animal behaviour

https://doi.org/10.18632/oncotarget.6596

Anna Kovalchuk, Richelle Mychasiuk, Arif Muhammad, Shakhawat Hossain, Slava Ilnytskyy, Abhijit Ghose, Charles Kirkby, Esmaeel Ghasroddashti, Olga Kovalchuk,  and Bryan Kolb
4385-4398
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Sildenafil (Viagra) sensitizes prostate cancer cells to doxorubicin-mediated apoptosis through CD95

Sildenafil (Viagra) sensitizes prostate cancer cells to doxorubicin-mediated apoptosis through CD95

https://doi.org/10.18632/oncotarget.6749

Anindita Das, David Durrant, Clint Mitchell, Paul Dent, Surinder K. Batra,  and Rakesh C. Kukreja
4399-4413
Abstract  |  PDF  |  HTML  |  Order a Reprint

GNA13 as a prognostic factor and mediator of gastric cancer progression

GNA13 as a prognostic factor and mediator of gastric cancer progression

https://doi.org/10.18632/oncotarget.6780

Jia-Xing Zhang, Miao Yun, Yi Xu, Jie-Wei Chen, Hui-Wen Weng, Zou-San Zheng, Cui Chen, Dan Xie,  and Sheng Ye
4414-4427
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Overcoming melanoma resistance to vemurafenib by targeting CCL2-induced miR-34a, miR-100 and miR-125b

Overcoming melanoma resistance to vemurafenib by targeting CCL2-induced miR-34a, miR-100 and miR-125b

https://doi.org/10.18632/oncotarget.6599

Elisabetta Vergani, Lorenza Di Guardo, Matteo Dugo, Sara Rigoletto, Gabrina Tragni, Roberta Ruggeri, Federica Perrone, Elena Tamborini, Annunziata Gloghini, Flavio Arienti, Barbara Vergani, Paola Deho, Loris De Cecco, Viviana Vallacchi, Paola Frati, Eriomina Shahaj, Antonello Villa, Mario Santinami, Filippo De Braud, Licia Rivoltini,  and Monica Rodolfo
4428-4441
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

p130Cas scaffold protein regulates ErbB2 stability by altering breast cancer cell sensitivity to autophagy

p130Cas scaffold protein regulates ErbB2 stability by altering breast cancer cell sensitivity to autophagy

https://doi.org/10.18632/oncotarget.6710

Brigitte Bisaro, Marianna Sciortino, Shana Colombo, Maria Pilar Camacho Leal, Andrea Costamagna, Isabella Castellano, Filippo Montemurro, Valentina Rossi, Giorgio Valabrega, Emilia Turco, Paola Defilippi,  and Sara Cabodi
4442-4453
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Induction of MAPK- and ROS-dependent autophagy and apoptosis in gastric carcinoma by combination of romidepsin and bortezomib

Induction of MAPK- and ROS-dependent autophagy and apoptosis in gastric carcinoma by combination of romidepsin and bortezomib

https://doi.org/10.18632/oncotarget.6601

Kwai Fung Hui, Po Ling Yeung,  and Alan K.S. Chiang
4454-4467
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Snail1 is required for the maintenance of the pancreatic acinar phenotype

Snail1 is required for the maintenance of the pancreatic acinar phenotype

https://doi.org/10.18632/oncotarget.6785

Jordina Loubat-Casanovas, Raúl Peña, Núria Gonzàlez, Lorena Alba-Castellón, Santi Rosell, Clara Francí, Pilar Navarro,  and Antonio García de Herreros
4468-4482
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Diabetes mellitus and the risk of glioma: a meta-analysis

Diabetes mellitus and the risk of glioma: a meta-analysis

https://doi.org/10.18632/oncotarget.6605

Luqian Zhao, Zhiping Zheng,  and Ping Huang
4483-4489
Abstract  |  PDF  |  HTML  |  Order a Reprint

Galiellalactone induces cell cycle arrest and apoptosis through the ATM/ATR pathway in prostate cancer cells

Galiellalactone induces cell cycle arrest and apoptosis through the ATM/ATR pathway in prostate cancer cells

https://doi.org/10.18632/oncotarget.6606

Víctor García, Maribel Lara-Chica, Irene Cantarero, Olov Sterner, Marco A. Calzado,  and Eduardo Muñoz
4490-4506
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Genome-wide profiling of DNA methylation and gene expression in esophageal squamous cell carcinoma

Genome-wide profiling of DNA methylation and gene expression in esophageal squamous cell carcinoma

https://doi.org/10.18632/oncotarget.6607

Chen Chen, Hao Peng, Xiaojie Huang, Ming Zhao, Zhi Li, Ni Yin, Xiang Wang, Fenglei Yu, Bangliang Yin, Yunchang Yuan,  and Qianjin Lu
4507-4521
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Identification of TIM3 2’-fluoro oligonucleotide aptamer by HT-SELEX for cancer immunotherapy

Identification of TIM3 2’-fluoro oligonucleotide aptamer by HT-SELEX for cancer immunotherapy

https://doi.org/10.18632/oncotarget.6608

Sandra Hervas-Stubbs, Mario M. Soldevilla, Helena Villanueva, Uxua Mancheño, Maurizio Bendandi,  and Fernando Pastor
4522-4530
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Possible prediction of the response of esophageal squamous cell carcinoma to neoadjuvant chemotherapy based on gene expression profiling

Possible prediction of the response of esophageal squamous cell carcinoma to neoadjuvant chemotherapy based on gene expression profiling

https://doi.org/10.18632/oncotarget.6554

Lu-Yan Shen, Hui Wang, Bin Dong, Wan-Pu Yan, Yao Lin, Qi Shi,  and Ke-Neng Chen
4531-4541
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The B56γ3 regulatory subunit-containing protein phosphatase 2A outcompetes Akt to regulate p27KIP1 subcellular localization by selectively dephosphorylating phospho-Thr157 of p27KIP1

The B56γ3 regulatory subunit-containing protein phosphatase 2A outcompetes Akt to regulate p27KIP1 subcellular localization by selectively dephosphorylating phospho-Thr157 of p27KIP1

https://doi.org/10.18632/oncotarget.6609

Tai-Yu Lai, Chia-Jui Yen, Hung-Wen Tsai, Yu-San Yang, Wei-Fu Hong,  and Chi-Wu Chiang
4542-4558
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MTDH is an oncogene in multiple myeloma, which is suppressed by Bortezomib treatment

MTDH is an oncogene in multiple myeloma, which is suppressed by Bortezomib treatment

https://doi.org/10.18632/oncotarget.6610

Chunyan Gu, Lang Feng, Hailin Peng, Hongbao Yang, Zhenqing Feng,  and Ye Yang
4559-4569
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A pyrazolopyran derivative preferentially inhibits the activity of human cytosolic serine hydroxymethyltransferase and induces cell death in lung cancer cells

A pyrazolopyran derivative preferentially inhibits the activity of human cytosolic serine hydroxymethyltransferase and induces cell death in lung cancer cells

https://doi.org/10.18632/oncotarget.6726

Marina Marani, Alessio Paone, Alessio Fiascarelli, Alberto Macone, Maurizio Gargano, Serena Rinaldo, Giorgio Giardina, Valentino Pontecorvi, David Koes, Lee McDermott, Tianyi Yang, Alessandro Paiardini, Roberto Contestabile,  and Francesca Cutruzzolà
4570-4583
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Prognostic value of high EZH2 expression in patients with different types of cancer: a systematic review with meta-analysis

Prognostic value of high EZH2 expression in patients with different types of cancer: a systematic review with meta-analysis

https://doi.org/10.18632/oncotarget.6612

Tao Jiang, Yan Wang, Fei Zhou, Guanghui Gao, Shengxiang Ren,  and Caicun Zhou
4584-4597
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Heightened BTK-dependent cell proliferation in unmutated chronic lymphocytic leukemia confers increased sensitivity to ibrutinib

Heightened BTK-dependent cell proliferation in unmutated chronic lymphocytic leukemia confers increased sensitivity to ibrutinib

https://doi.org/10.18632/oncotarget.6727

Ailin Guo, Pin Lu, Natalie Galanina, Chadi Nabhan, Sonali M. Smith, Morton Coleman,  and Y. Lynn Wang
4598-4610
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

High-throughput qRT-PCR validation of blood microRNAs in non-small cell lung cancer

High-throughput qRT-PCR validation of blood microRNAs in non-small cell lung cancer

https://doi.org/10.18632/oncotarget.6566

Petra Leidinger, Thomas Brefort, Christina Backes, Medea Krapp, Valentina Galata, Markus Beier, Jochen Kohlhaas, Hanno Huwer, Eckart Meese,  and Andreas Keller
4611-4623
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Deep sequencing of uveal melanoma identifies a recurrent mutation in PLCB4

Deep sequencing of uveal melanoma identifies a recurrent mutation in PLCB4

https://doi.org/10.18632/oncotarget.6614

Peter Johansson, Lauren G. Aoude, Karin Wadt, William J. Glasson, Sunil K. Warrier, Alex W. Hewitt, Jens Folke Kiilgaard, Steffen Heegaard, Tim Isaacs, Maria Franchina, Christian Ingvar, Tersia Vermeulen, Kevin J. Whitehead, Christopher W. Schmidt, Jane M. Palmer, Judith Symmons, Anne-Marie Gerdes, Göran Jönsson,  and Nicholas K. Hayward
4624-4631
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Regulation of the epithelial to mesenchymal transition and metastasis by Raf kinase inhibitory protein-dependent Notch1 activity

Regulation of the epithelial to mesenchymal transition and metastasis by Raf kinase inhibitory protein-dependent Notch1 activity

https://doi.org/10.18632/oncotarget.6728

Hae Sook Noh, Young-Sool Hah, Ji Hye Ha, Min Young Kang, Sahib Zada, Sun Young Rha, Sang Soo Kang, Hyun Joon Kim, Jae-Yong Park, June-Ho Byun, Jong Ryeal Hahm, Jeong Kyu Shin, Sang-Ho Jeong, Young-Joon Lee,  and Deok Ryong Kim
4632-4646
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MicroRNA-1225-5p inhibits proliferation and metastasis of gastric carcinoma through repressing insulin receptor substrate-1 and activation of β-catenin signaling

MicroRNA-1225-5p inhibits proliferation and metastasis of gastric carcinoma through repressing insulin receptor substrate-1 and activation of β-catenin signaling

https://doi.org/10.18632/oncotarget.6615

Haiyin Zheng, Fuxing Zhang, Xinjian Lin, Changming Huang, Yiqin Zhang, Yun Li, Jianyin Lin, Wannan Chen,  and Xu Lin
4647-4663
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Emodin potentiates the antiproliferative effect of interferon α/β by activation of JAK/STAT pathway signaling through inhibition of the 26S proteasome

Emodin potentiates the antiproliferative effect of interferon α/β by activation of JAK/STAT pathway signaling through inhibition of the 26S proteasome

https://doi.org/10.18632/oncotarget.6616

Yujiao He, Junmei Huang, Ping Wang, Xiaofei Shen, Sheng Li, Lijuan Yang, Wanli Liu, Apichart Suksamrarn, Guolin Zhang,  and Fei Wang
4664-4679
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

EGFRvIII/integrin β3 interaction in hypoxic and vitronectinenriching microenvironment promote GBM progression and metastasis

EGFRvIII/integrin β3 interaction in hypoxic and vitronectinenriching microenvironment promote GBM progression and metastasis

https://doi.org/10.18632/oncotarget.6730

Zhaoyu Liu, Lei Han, Yucui Dong, Yanli Tan, Yongsheng Li, Manli Zhao, Hui Xie, Huanyu Ju, He Wang, Yu Zhao, Qifan Zheng, Qixue Wang, Jun Su, Chuan Fang, Songbin Fu, Tao Jiang, Jiaren Liu, Xia Li, Chunsheng Kang,  and Huan Ren
4680-4694
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The role of HDAC2 in chromatin remodelling and response to chemotherapy in ovarian cancer

The role of HDAC2 in chromatin remodelling and response to chemotherapy in ovarian cancer

https://doi.org/10.18632/oncotarget.6618

Rui Huang, Simon P. Langdon, Matthew Tse, Peter Mullen, In Hwa Um, Dana Faratian,  and David J. Harrison
4695-4711
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Long noncoding RNA Hotair mediated angiogenesis in nasopharyngeal carcinoma by direct and indirect signaling pathways

Long noncoding RNA Hotair mediated angiogenesis in nasopharyngeal carcinoma by direct and indirect signaling pathways

https://doi.org/10.18632/oncotarget.6731

Wei-ming Fu, Ying-fei Lu, Bao-guang Hu, Wei-cheng Liang, Xiao Zhu, Hai-di Yang, Gang Li,  and Jin-fang Zhang
4712-4723
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Identification of a novel RNA giant nuclear body in cancer cells

Identification of a novel RNA giant nuclear body in cancer cells

https://doi.org/10.18632/oncotarget.6619

Hong Zhou, Jiawei Zhang, Ying Gu, Xiaoxian Gan, Yichao Gan, Weiwei Zheng, Byung-Wook Kim, Xiaohua Xu, Xiaoya Lu, Qi Dong, Shu Zheng, Wendong Huang,  and Rongzhen Xu
4724-4734
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

miR-183 regulates autophagy and apoptosis in colorectal cancer through targeting of UVRAG

miR-183 regulates autophagy and apoptosis in colorectal cancer through targeting of UVRAG

https://doi.org/10.18632/oncotarget.6732

Longtao Huangfu, Haihai Liang, Guojie Wang, Xiaomin Su, Linqiang Li, Zhimin Du, Meiyu Hu, Yuechao Dong, Xue Bai, Tianyi Liu, Baofeng Yang,  and Hongli Shan
4735-4745
Abstract  |  PDF  |  HTML  |  Order a Reprint

Dysregulated miR-671-5p / CDR1-AS / CDR1 / VSNL1 axis is involved in glioblastoma multiforme

Dysregulated miR-671-5p / CDR1-AS / CDR1 / VSNL1 axis is involved in glioblastoma multiforme

https://doi.org/10.18632/oncotarget.6621

Davide Barbagallo, Angelo Condorelli, Marco Ragusa, Loredana Salito, Mariangela Sammito, Barbara Banelli, Rosario Caltabiano, Giuseppe Barbagallo, Agata Zappalà, Rosalia Battaglia, Matilde Cirnigliaro, Salvatore Lanzafame, Enrico Vasquez, Rosalba Parenti, Federico Cicirata, Cinzia Di Pietro, Massimo Romani,  and Michele Purrello
4746-4759
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MDSC-decreasing chemotherapy increases the efficacy of cytokine-induced killer cell immunotherapy in metastatic renal cell carcinoma and pancreatic cancer

MDSC-decreasing chemotherapy increases the efficacy of cytokine-induced killer cell immunotherapy in metastatic renal cell carcinoma and pancreatic cancer

https://doi.org/10.18632/oncotarget.6734

Zibing Wang, Yuqing Liu, Yong Zhang, Yiman Shang,  and Quanli Gao
4760-4769
Abstract  |  PDF  |  HTML  |  Order a Reprint

Low expression of BMPRIB indicates poor prognosis of breast cancer and is insensitive to taxane-anthracycline chemotherapy

Low expression of BMPRIB indicates poor prognosis of breast cancer and is insensitive to taxane-anthracycline chemotherapy

https://doi.org/10.18632/oncotarget.6613

Kun Dai, Fengxia Qin, Huikun Zhang, Xiaoli Liu, Caixia Guo, Ming Zhang, Feng Gu, Li Fu,  and Yongjie Ma
4770-4784
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MicroRNA-584-3p, a novel tumor suppressor and prognostic marker, reduces the migration and invasion of human glioma cells by targeting hypoxia-induced ROCK1

MicroRNA-584-3p, a novel tumor suppressor and prognostic marker, reduces the migration and invasion of human glioma cells by targeting hypoxia-induced ROCK1

https://doi.org/10.18632/oncotarget.6735

Hao Xue, Xing Guo, Xiao Han, Shaofeng Yan, Jinsen Zhang, Shugang Xu, Tong Li, Xiaofan Guo, Ping Zhang, Xiao Gao, Qinglin Liu,  and Gang Li
4785-4805
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Angiomirs expression profiling in diffuse large B-Cell lymphoma

Angiomirs expression profiling in diffuse large B-Cell lymphoma

https://doi.org/10.18632/oncotarget.6624

Natália M. Borges, Marcela do Vale Elias, Veruska L. Fook-Alves, Tathiana A. Andrade, Marina Lourenço de Conti, Mariana Petaccia Macedo, Maria Dirlei Begnami, Antônio Hugo J. F. M. Campos, Leina Yukari Etto, Adriana Bruscato Bortoluzzo, Antonio C. Alves, Ken H. Young,  and Gisele W. B. Colleoni
4806-4816
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

miR-215 promotes malignant progression of gastric cancer by targeting RUNX1

miR-215 promotes malignant progression of gastric cancer by targeting RUNX1

https://doi.org/10.18632/oncotarget.6736

Na Li, Qi-Yue Zhang, Jian-Ling Zou, Zhong-Wu Li, Tian-Tian Tian, Bin Dong, Xi-Juan Liu, Sai Ge, Yan Zhu, Jing Gao,  and Lin Shen
4817-4828
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Hyaluronan stimulates pancreatic cancer cell motility

Hyaluronan stimulates pancreatic cancer cell motility

https://doi.org/10.18632/oncotarget.6617

Xiao-Bo Cheng, Shiro Kohi, Atsuhiro Koga, Keiji Hirata,  and Norihiro Sato
4829-4840
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

PIG7 promotes leukemia cell chemosensitivity via lysosomal membrane permeabilization

PIG7 promotes leukemia cell chemosensitivity via lysosomal membrane permeabilization

https://doi.org/10.18632/oncotarget.6739

Jiazhuo Liu, Leiwen Peng, Ting Niu, Yu Wu, Jianjun Li, Fangfang Wang, Yuhuan Zheng,  and Ting Liu
4841-4859
Abstract  |  PDF  |  HTML  |  Order a Reprint

Sorafenib treatment during partial hepatectomy reduces tumorgenesis in an inflammation-associated liver cancer model

Sorafenib treatment during partial hepatectomy reduces tumorgenesis in an inflammation-associated liver cancer model

https://doi.org/10.18632/oncotarget.6638

Tamar Zahavi, Tali Lanton, Mali Salmon Divon, Asher Salmon, Tamar Peretz, Eithan Galun, Jonathan H. Axelrod,  and Amir Sonnenblick
4860-4870
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

High expression levels of MAGE-A9 are correlated with unfavorable survival in lung adenocarcinoma

High expression levels of MAGE-A9 are correlated with unfavorable survival in lung adenocarcinoma

https://doi.org/10.18632/oncotarget.6741

Xiaolu Zhai, Liqin Xu, Siya Zhang, Huijun Zhu, Guoxin Mao,  and Jianfei Huang
4871-4881
Abstract  |  PDF  |  HTML  |  Order a Reprint

Annexin A8 is a novel molecular marker for detecting lymph node metastasis in oral squamous cell carcinoma

Annexin A8 is a novel molecular marker for detecting lymph node metastasis in oral squamous cell carcinoma

https://doi.org/10.18632/oncotarget.6639

Ryota Oka, Koh-ichi Nakashiro, Hiroyuki Goda, Kazuki Iwamoto, Norihiko Tokuzen,  and Hiroyuki Hamakawa
4882-4889
Abstract  |  PDF  |  HTML  |  Order a Reprint

PKCδ activated by c-MET enhances infiltration of human glioblastoma cells through NOTCH2 signaling

PKCδ activated by c-MET enhances infiltration of human glioblastoma cells through NOTCH2 signaling

https://doi.org/10.18632/oncotarget.6640

Eunji Hwang, Ki-Chun Yoo, Seok-Gu Kang, Rae-Kwon Kim, Yan-Hong Cui, Hae-June Lee, Min-Jung Kim, Jae-Seong Lee, In-Gyu Kim, Yongjoon Suh,  and Su-Jae Lee
4890-4902
Abstract  |  PDF  |  HTML  |  Order a Reprint

Genome-wide analysis of Epstein-Barr virus (EBV) isolated from EBV-associated gastric carcinoma (EBVaGC)

Genome-wide analysis of Epstein-Barr virus (EBV) isolated from EBV-associated gastric carcinoma (EBVaGC)

https://doi.org/10.18632/oncotarget.6751

Ying Liu, Wenjun Yang, Yaqi Pan, Jiafu Ji, Zheming Lu,  and Yang Ke
4903-4914
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Let-7c down-regulation in Helicobacter pylori-related gastric carcinogenesis

Let-7c down-regulation in Helicobacter pylori-related gastric carcinogenesis

https://doi.org/10.18632/oncotarget.6642

Matteo Fassan, Deborah Saraggi, Laura Balsamo, Luciano Cascione, Carlo Castoro, Irene Coati, Marina De Bernard, Fabio Farinati, Vincenza Guzzardo, Nicola Valeri, Carlo Federico Zambon,  and Massimo Rugge
4915-4924
Abstract  |  PDF  |  HTML  |  Order a Reprint

Serum level of hepatocyte growth factor is a novel marker of predicting the outcome and resistance to the treatment with trastuzumab in HER2-positive patients with metastatic gastric cancer

Serum level of hepatocyte growth factor is a novel marker of predicting the outcome and resistance to the treatment with trastuzumab in HER2-positive patients with metastatic gastric cancer

https://doi.org/10.18632/oncotarget.6753

Naoki Takahashi, Koh Furuta, Hirokazu Taniguchi, Yusuke Sasaki, Hirokazu Shoji, Yoshitaka Honma, Satoru Iwasa, Natsuko Okita, Atsuo Takashima, Ken Kato, Tetsuya Hamaguchi, Yasuhiro Shimada,  and Yasuhide Yamada
4925-4938
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Adipocytes promote prostate cancer stem cell self-renewal through amplification of the cholecystokinin autocrine loop

Adipocytes promote prostate cancer stem cell self-renewal through amplification of the cholecystokinin autocrine loop

https://doi.org/10.18632/oncotarget.6643

Kai-Dun Tang, Ji Liu, Lidija Jovanovic, Jiyuan An, Michelle M. Hill, Ian Vela, Terence Kin-Wah Lee, Stephanie Ma, Colleen Nelson, Pamela J. Russell, Judith A. Clements,  and Ming-Tat Ling
4939-4948
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Cell cycle-dependent resolution of DNA double-strand breaks

Cell cycle-dependent resolution of DNA double-strand breaks

https://doi.org/10.18632/oncotarget.6644

Susanna Ambrosio, Giacomo Di Palo, Giuliana Napolitano, Stefano Amente, Gaetano Ivan Dellino, Mario Faretta, Pier Giuseppe Pelicci, Luigi Lania,  and Barbara Majello
4949-4960
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The drug target genes show higher evolutionary conservation than non-target genes

The drug target genes show higher evolutionary conservation than non-target genes

https://doi.org/10.18632/oncotarget.6755

Wenhua Lv, Yongdeng Xu, Yiying Guo, Ziqi Yu, Guanglong Feng, Panpan Liu, Meiwei Luan, Hongjie Zhu, Guiyou Liu, Mingming Zhang, Hongchao Lv, Lian Duan, Zhenwei Shang, Jin Li, Yongshuai Jiang,  and Ruijie Zhang
4961-4971
Abstract  |  PDF  |  HTML  |  Order a Reprint

Epstein-Barr virus mir-bart1-5p detection via nasopharyngeal brush sampling is effective for diagnosing nasopharyngeal carcinoma

Epstein-Barr virus mir-bart1-5p detection via nasopharyngeal brush sampling is effective for diagnosing nasopharyngeal carcinoma

https://doi.org/10.18632/oncotarget.6649

Xiao-Hui Zheng, Li-Xia Lu, Cui Cui, Ming-Yuan Chen, Xi-Zhao Li,  and Wei-Hua Jia
4972-4980
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Genetic variants in ERBB4 is associated with chronic hepatitis B virus infection

Genetic variants in ERBB4 is associated with chronic hepatitis B virus infection

https://doi.org/10.18632/oncotarget.6650

Yao Liu, Qun Zhou, Xiao-Shun He, Li-Ming Song, Lin Chen, Wei-Juan Jiao, Tong Shen, Su Yao, Hua Wu, Zhi-Bin Hu, Tian-Ming Gao,  and Jian-Ming Li
4981-4992
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

SATB1 and SATB2 play opposing roles in c-Myc expression and progression of colorectal cancer

SATB1 and SATB2 play opposing roles in c-Myc expression and progression of colorectal cancer

https://doi.org/10.18632/oncotarget.6651

Mohammed A. Mansour, Toshinori Hyodo, Khondker Ayesha Akter, Toshio Kokuryo, Keisuke Uehara, Masato Nagino,  and Takeshi Senga
4993-5006
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miR-101 reverses hypomethylation of the PRDM16 promoter to disrupt mitochondrial function in astrocytoma cells

miR-101 reverses hypomethylation of the PRDM16 promoter to disrupt mitochondrial function in astrocytoma cells

https://doi.org/10.18632/oncotarget.6652

Qianqian Lei, Xiaoping Liu, Haijuan Fu, Yingnan Sun, Liping Wang, Gang Xu, Wei Wang, Zhibin Yu, Changhong Liu, Peiyao Li, Jianbo Feng, Guiyuan Li,  and Minghua Wu
5007-5022
Abstract  |  PDF  |  HTML  |  Order a Reprint

Association of cancer mortality with postdiagnosis overweight and obesity using body mass index

Association of cancer mortality with postdiagnosis overweight and obesity using body mass index

https://doi.org/10.18632/oncotarget.6517

Xinsen Xu, Lei Zhou, Runchen Miao, Wei Chen, Yanyan Zhou, Qing Pang, Kai Qu,  and Chang Liu
5023-5029
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Clinical Research Papers

Biomarker-based prognostic stratification of young adult glioblastoma

Biomarker-based prognostic stratification of young adult glioblastoma

https://doi.org/10.18632/oncotarget.5456

Rui-qi Zhang, Zhifeng Shi, Hong Chen, Nellie Yuk-Fei Chung, Zi Yin, Kay Ka-Wai Li, Danny Tat-Ming Chan, Wai Sang Poon, Jinsong Wu, Liangfu Zhou, Aden Ka-yin Chan, Ying Mao,  and Ho-Keung Ng
5030-5041
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A genome-wide association study identifies WT1 variant with better response to 5-fluorouracil, pirarubicin and cyclophosphamide neoadjuvant chemotherapy in breast cancer patients

A genome-wide association study identifies WT1 variant with better response to 5-fluorouracil, pirarubicin and cyclophosphamide neoadjuvant chemotherapy in breast cancer patients

https://doi.org/10.18632/oncotarget.5837

Lina Wu, Lu Yao, Hong Zhang, Tao Ouyang, Jinfeng Li, Tianfeng Wang, Zhaoqing Fan, Tie Fan, Benyao Lin, Cameron C. Yin,  and Yuntao Xie
5042-5052
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Nomogram basing pre-treatment parameters predicting early response for locally advanced rectal cancer with neoadjuvant chemotherapy alone: a subgroup efficacy analysis of FOWARC study

Nomogram basing pre-treatment parameters predicting early response for locally advanced rectal cancer with neoadjuvant chemotherapy alone: a subgroup efficacy analysis of FOWARC study

https://doi.org/10.18632/oncotarget.6469

Jianwei Zhang, Yue Cai, Huabin Hu, Ping Lan, Lei Wang, Meijin Huang, Liang Kang, Xiaojian Wu, Hui Wang, Jiayu Ling, Jian Xiao, Jianping Wang,  and Yanhong Deng
5053-5062
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FGFR1 is an adverse outcome indicator for luminal A breast cancers

FGFR1 is an adverse outcome indicator for luminal A breast cancers

https://doi.org/10.18632/oncotarget.6563

Yu-Jie Shi, Julia Y.S. Tsang, Yun-Bi Ni, Siu-Ki Chan, Kui-Fat Chan,  and Gary M. Tse
5063-5073
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Tumors with high-density tumor infiltrating lymphocytes constitute a favorable entity in breast cancer: a pooled analysis of four prospective adjuvant trials

Tumors with high-density tumor infiltrating lymphocytes constitute a favorable entity in breast cancer: a pooled analysis of four prospective adjuvant trials

https://doi.org/10.18632/oncotarget.6231

Vassiliki Kotoula, Kyriakos Chatzopoulos, Sotiris Lakis, Zoi Alexopoulou, Eleni Timotheadou, Flora Zagouri, George Pentheroudakis, Helen Gogas, Eleni Galani, Ioannis Efstratiou, Thomas Zaramboukas, Angelos Koutras, Gerasimos Aravantinos, Epaminontas Samantas, Amanda Psyrri, Helen Kourea, Mattheos Bobos, Pavlos Papakostas, Paris Kosmidis, Dimitrios Pectasides,  and George Fountzilas
5074-5087
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Case Reports

Methimazole-induced cholestatic hepatitis: two cases report and literature review

Methimazole-induced cholestatic hepatitis: two cases report and literature review

https://doi.org/10.18632/oncotarget.6144

Hai Zou, Lie Jin, Li-Ren Wang, Martin Braddock, Wen-Wei Cai,  and Ming-Hua Zheng
5088-5091
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