Oncotarget

Vol 7, No 3

January 19, 2016

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About The Cover

γKlotho is a Novel Marker and Cell Survival Factor in a Subset of Triple Negative Breast Cancers. Cover art by J. Weon, See Trošt et al. 

Table of Contents

Research Perspectives

Click chemistry, 3D-printing, and omics: the future of drug development

Click chemistry, 3D-printing, and omics: the future of drug development

https://doi.org/10.18632/oncotarget.6787

Razelle Kurzrock,  and David J. Stewart
2155-2158
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Priority Research Papers

Oncogenic KRAS activates an embryonic stem cell-like program in human colon cancer initiation

Oncogenic KRAS activates an embryonic stem cell-like program in human colon cancer initiation

https://doi.org/10.18632/oncotarget.6818

Anne-France Le Rolle, Thang K. Chiu, Zhaoshi Zeng, Jinru Shia, Martin R. Weiser, Philip B. Paty,  and Vi K. Chiu
2159-2174
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Research Papers: Gerotarget (Focus on Aging)

Aldehyde dehydrogenase 2 activation in aged heart improves the autophagy by reducing the carbonyl modification on SIRT1

Aldehyde dehydrogenase 2 activation in aged heart improves the autophagy by reducing the carbonyl modification on SIRT1

https://doi.org/10.18632/oncotarget.6814

Bing Wu, Lu Yu, Yishi Wang, Hongtao Wang, Chen Li, Yue Yin, Jingrun Yang, Zhifa Wang, Qiangsun Zheng,  and Heng Ma
2175-2188
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Research Papers: Pathology

Nucleus pulposus phenotypic markers to determine stem cell differentiation: fact or fiction?

Nucleus pulposus phenotypic markers to determine stem cell differentiation: fact or fiction?

https://doi.org/10.18632/oncotarget.6782

Abbey A. Thorpe, Abbie L.A. Binch, Laura B. Creemers, Christopher Sammon,  and Christine L. Le Maitre
2189-2200
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MiRNA-133b promotes the proliferation of human Sertoli cells through targeting GLI3

MiRNA-133b promotes the proliferation of human Sertoli cells through targeting GLI3

https://doi.org/10.18632/oncotarget.6876

Chencheng Yao, Min Sun, Qingqing Yuan, Minghui Niu, Zheng Chen, Jingmei Hou, Hong Wang, Liping Wen, Yun Liu, Zheng Li,  and Zuping He
2201-2219
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Research Papers: Immunology

Increased serum NKG2D-ligands and downregulation of NKG2D in peripheral blood NK cells of patients with major burns

Increased serum NKG2D-ligands and downregulation of NKG2D in peripheral blood NK cells of patients with major burns

https://doi.org/10.18632/oncotarget.6789

Josef Haik, Gil Nardini, Noga Goldman, Gilli Galore-Haskel, Moti Harats, Isaac Zilinsky, Oren Weissman, Jacob Schachter, Eyal Winkler,  and Gal Markel
2220-2228
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Chicoric acid binds to two sites and decreases the activity of the YopH bacterial virulence factor

Chicoric acid binds to two sites and decreases the activity of the YopH bacterial virulence factor

https://doi.org/10.18632/oncotarget.6812

Alicja Kuban-Jankowska, Kamlesh K. Sahu, Magdalena Gorska, Jack A. Tuszynski,  and Michal Wozniak
2229-2238
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Research Papers: Autophagy and Cell Death

Caspase inhibition impaired the neural stem/progenitor cell response after cortical ischemia in mice

Caspase inhibition impaired the neural stem/progenitor cell response after cortical ischemia in mice

https://doi.org/10.18632/oncotarget.6803

Ahmed M. Osman, Susanne Neumann, H. Georg Kuhn,  and Klas Blomgren
2239-2248
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VDAC3 as a sensor of oxidative state of the intermembrane space of mitochondria: the putative role of cysteine residue modifications

VDAC3 as a sensor of oxidative state of the intermembrane space of mitochondria: the putative role of cysteine residue modifications

https://doi.org/10.18632/oncotarget.6850

Simona Reina, Vanessa Checchetto, Rosaria Saletti, Ankit Gupta, Deepti Chaturvedi, Carlo Guardiani, Francesca Guarino, Mariano Andrea Scorciapino, Andrea Magrì, Salvatore Foti, Matteo Ceccarelli, Angela Anna Messina, Radhakrishnan Mahalakshmi, Ildiko Szabo,  and Vito De Pinto
2249-2268
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Research Papers: Chromosome

Polo-like kinase 1 mediates BRCA1 phosphorylation and recruitment at DNA double-strand breaks

Polo-like kinase 1 mediates BRCA1 phosphorylation and recruitment at DNA double-strand breaks

https://doi.org/10.18632/oncotarget.6825

Corinne Chabalier-Taste, Laetitia Brichese, Carine Racca, Yvan Canitrot, Patrick Calsou,  and Florence Larminat
2269-2283
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Reviews

EZH2 in normal hematopoiesis and hematological malignancies

EZH2 in normal hematopoiesis and hematological malignancies

https://doi.org/10.18632/oncotarget.6198

Laurie Herviou, Giacomo Cavalli, Guillaume Cartron, Bernard Klein,  and Jérôme Moreaux
2284-2296
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MEF2 transcription factors: developmental regulators and emerging cancer genes

MEF2 transcription factors: developmental regulators and emerging cancer genes

https://doi.org/10.18632/oncotarget.6223

Julia R. Pon,  and Marco A. Marra
2297-2312
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Bevacizumab and radiotherapy for the treatment of glioblastoma: brothers in arms or unholy alliance?

Bevacizumab and radiotherapy for the treatment of glioblastoma: brothers in arms or unholy alliance?

https://doi.org/10.18632/oncotarget.6320

Maximilian Niyazi, Patrick N. Harter, Elke Hattingen, Maya Rottler, Louisa von Baumgarten, Martin Proescholdt, Claus Belka, Kirsten Lauber,  and Michel Mittelbronn
2313-2328
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Research Papers

The clinical development candidate CCT245737 is an orally active CHK1 inhibitor with preclinical activity in RAS mutant NSCLC and Eµ-MYC driven B-cell lymphoma

The clinical development candidate CCT245737 is an orally active CHK1 inhibitor with preclinical activity in RAS mutant NSCLC and Eµ-MYC driven B-cell lymphoma

https://doi.org/10.18632/oncotarget.4919

Mike I. Walton, Paul D. Eve, Angela Hayes, Alan T. Henley, Melanie R. Valenti, Alexis K. De Haven Brandon, Gary Box, Kathy J. Boxall, Matthew Tall, Karen Swales, Thomas P. Matthews, Tatiana McHardy, Michael Lainchbury, James Osborne, Jill E. Hunter, Neil D. Perkins, G. Wynne Aherne, John C. Reader, Florence I. Raynaud, Suzanne A. Eccles, Ian Collins,  and Michelle D. Garrett
2329-2342
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Therapeutic potential of targeting cell division cycle associated 5 for oral squamous cell carcinoma

Therapeutic potential of targeting cell division cycle associated 5 for oral squamous cell carcinoma

https://doi.org/10.18632/oncotarget.6148

Norihiko Tokuzen, Koh-ichi Nakashiro, Hiroshi Tanaka, Kazuki Iwamoto,  and Hiroyuki Hamakawa
2343-2353
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Overexpression of TREM2 enhances glioma cell proliferation and invasion: a therapeutic target in human glioma

Overexpression of TREM2 enhances glioma cell proliferation and invasion: a therapeutic target in human glioma

https://doi.org/10.18632/oncotarget.6221

Xiao-Qiang Wang, Bang-Bao Tao, Bin Li, Xu-Hui Wang, Wen-Chuan Zhang, Liang Wan, Xu-Ming Hua,  and Shi-Ting Li
2354-2366
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Disentangling the microRNA regulatory milieu in multiple myeloma: integrative genomics analysis outlines mixed miRNA-TF circuits and pathway-derived networks modulated in t(4;14) patients

Disentangling the microRNA regulatory milieu in multiple myeloma: integrative genomics analysis outlines mixed miRNA-TF circuits and pathway-derived networks modulated in t(4;14) patients

https://doi.org/10.18632/oncotarget.6151

Enrica Calura, Andrea Bisognin, Martina Manzoni, Katia Todoerti, Elisa Taiana, Gabriele Sales, Gareth J. Morgan, Giovanni Tonon, Nicola Amodio, Pierfrancesco Tassone, Antonino Neri, Luca Agnelli, Chiara Romualdi,  and Stefania Bortoluzzi
2367-2378
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Transcription factor LSF (TFCP2) inhibits melanoma growth

Transcription factor LSF (TFCP2) inhibits melanoma growth

https://doi.org/10.18632/oncotarget.6230

Yuji Goto, Ichiro Yajima, Mayuko Kumasaka, Nobutaka Ohgami, Asami Tanaka, Toyonori Tsuzuki, Yuji Inoue, Satoshi Fukushima, Hironobu Ihn, Mikiko Kyoya, Hiroyuki Ohashi, Tamihiro Kawakami, Dorothy C. Bennett,  and Masashi Kato
2379-2390
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Inhibition of the miR-155 target NIAM phenocopies the growth promoting effect of miR-155 in B-cell lymphoma

Inhibition of the miR-155 target NIAM phenocopies the growth promoting effect of miR-155 in B-cell lymphoma

https://doi.org/10.18632/oncotarget.6165

Izabella Slezak-Prochazka, Joost Kluiver, Debora de Jong, Katarzyna Smigielska-Czepiel, Gertrud Kortman, Melanie Winkle, Bea Rutgers, Jasper Koerts, Lydia Visser, Arjan Diepstra, Bart-Jan Kroesen,  and Anke van den Berg
2391-2400
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Prognostic impact of concurrent MYC and BCL6 rearrangements and expression in de novo diffuse large B-cell lymphoma

Prognostic impact of concurrent MYC and BCL6 rearrangements and expression in de novo diffuse large B-cell lymphoma

https://doi.org/10.18632/oncotarget.6262

Qing Ye, Zijun Y. Xu-Monette, Alexandar Tzankov, Lijuan Deng, Xiaoxiao Wang, Ganiraju C. Manyam, Carlo Visco, Santiago Montes-Moreno, Li Zhang, Karen Dybkær, April Chiu, Attilio Orazi, Youli Zu, Govind Bhagat, Kristy L. Richards, Eric D. Hsi, William W.L. Choi, J. Han van Krieken, Jooryung Huh, Maurilio Ponzoni, Andrés J.M. Ferreri, Ben M. Parsons, Michael B. Møller, Miguel A. Piris, Jane N. Winter, L. Jeffrey Medeiros, Shimin Hu,  and Ken H. Young
2401-2416
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MicroRNA-708-5p acts as a therapeutic agent against metastatic lung cancer

MicroRNA-708-5p acts as a therapeutic agent against metastatic lung cancer

https://doi.org/10.18632/oncotarget.6594

Xiaoping Wu, Tianchi Liu, Ou Fang, Wenhua Dong, Fengjun Zhang, Lindsey Leach, Xiaohua Hu,  and Zewei Luo
2417-2432
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BRCA1/2 mutations perturb telomere biology: characterization of structural and functional abnormalities in vitro and in vivo

BRCA1/2 mutations perturb telomere biology: characterization of structural and functional abnormalities in vitro and in vivo

https://doi.org/10.18632/oncotarget.5693

Orit Uziel, Rinat Yerushalmi, Lital Zuriano, Shaden Naser, Einat Beery, Jardena Nordenberg, Ido Lubin, Yonatan Adel, Daniel Shepshelovich, Hagai Yavin, Irit Ben Aharon, Shlomit Pery, Shulamit Rizel, Metsada Pasmanik-Chor, Dan Frumkin,  and Meir Lahav
2433-2454
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Transforming growth factor-β1 polymorphisms and graft-versus-host disease risk: a meta-analysis

Transforming growth factor-β1 polymorphisms and graft-versus-host disease risk: a meta-analysis

https://doi.org/10.18632/oncotarget.6289

Lin Zhang, Lihong Mao,  and Junxiu Xu
2455-2461
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Suppression of BRD4 inhibits human hepatocellular carcinoma by repressing MYC and enhancing BIM expression

Suppression of BRD4 inhibits human hepatocellular carcinoma by repressing MYC and enhancing BIM expression

https://doi.org/10.18632/oncotarget.6275

Gong-Quan Li, Wen-Zhi Guo, Yi Zhang, Jing-Jing Seng, Hua-Peng Zhang, Xiu-Xian Ma, Gong Zhang, Jie Li, Bing Yan, Hong-Wei Tang, Shan-Shan Li, Li-Dong Wang,  and Shui-Jun Zhang
2462-2474
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NOVA1 inhibition by miR-146b-5p in the remnant tissue microenvironment defines occult residual disease after gastric cancer removal

NOVA1 inhibition by miR-146b-5p in the remnant tissue microenvironment defines occult residual disease after gastric cancer removal

https://doi.org/10.18632/oncotarget.6542

Sun Och Yoon, Eun Kyung Kim, Mira Lee, Woon Yong Jung, Hyunjoo Lee, Youngran Kang, You-Jin Jang, Soon Won Hong, Seung Ho Choi,  and Woo Ick Yang
2475-2495
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Adoptive immunotherapy using T lymphocytes redirected to glypican-3 for the treatment of lung squamous cell carcinoma

Adoptive immunotherapy using T lymphocytes redirected to glypican-3 for the treatment of lung squamous cell carcinoma

https://doi.org/10.18632/oncotarget.6595

Kesang Li, Xiaorong Pan, Yanyu Bi, Wen Xu, Cheng Chen, Huiping Gao, Bizhi Shi, Hua Jiang, Shengli Yang, Liyan Jiang,  and Zonghai Li
2496-2507
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Tumor-associated fibroblast-conditioned medium induces CDDP resistance in HNSCC cells

Tumor-associated fibroblast-conditioned medium induces CDDP resistance in HNSCC cells

https://doi.org/10.18632/oncotarget.6210

Teresa Bernadette Steinbichler, Veronika Metzler, Christian Pritz, Herbert Riechelmann,  and Jozsef Dudas
2508-2518
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LKB1 promotes cell survival by modulating TIF-IA-mediated pre-ribosomal RNA synthesis under uridine downregulated conditions

LKB1 promotes cell survival by modulating TIF-IA-mediated pre-ribosomal RNA synthesis under uridine downregulated conditions

https://doi.org/10.18632/oncotarget.6224

Fakeng Liu, Rui Jin, Xiuju Liu, Henry Huang, Scott C. Wilkinson, Diansheng Zhong, Fadlo R. Khuri, Haian Fu, Adam Marcus, Yulong He,  and Wei Zhou
2519-2531
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Simvastatin-induced breast cancer cell death and deactivation of PI3K/Akt and MAPK/ERK signalling are reversed by metabolic products of the mevalonate pathway

Simvastatin-induced breast cancer cell death and deactivation of PI3K/Akt and MAPK/ERK signalling are reversed by metabolic products of the mevalonate pathway

https://doi.org/10.18632/oncotarget.6304

Tingting Wang, Serena Seah, Xinyi Loh, Ching-Wan Chan, Mikael Hartman, Boon-Cher Goh,  and Soo-Chin Lee
2532-2544
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Concomitant BET and MAPK blockade for effective treatment of ovarian cancer

Concomitant BET and MAPK blockade for effective treatment of ovarian cancer

https://doi.org/10.18632/oncotarget.6309

Ying Jing, Zhenfeng Zhang, Pengfei Ma, Shimin An, Ying Shen, Liang Zhu,  and Guanglei Zhuang
2545-2554
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Computational selection of antibody-drug conjugate targets for breast cancer

Computational selection of antibody-drug conjugate targets for breast cancer

https://doi.org/10.18632/oncotarget.6679

François Fauteux, Jennifer J. Hill, Maria L. Jaramillo, Youlian Pan, Sieu Phan, Fazel Famili,  and Maureen O’Connor-McCourt
2555-2571
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Tie-2 regulates the stemness and metastatic properties of prostate cancer cells

Tie-2 regulates the stemness and metastatic properties of prostate cancer cells

https://doi.org/10.18632/oncotarget.3950

Kai-Dun Tang, Boris M. Holzapfel, Ji Liu, Terence Kin-Wah Lee, Stephanie Ma, Lidija Jovanovic, Jiyuan An, Pamela J. Russell, Judith A. Clements, Dietmar W. Hutmacher,  and Ming-Tat Ling
2572-2584
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Overexpression of ATP1B1 predicts an adverse prognosis in cytogenetically normal acute myeloid leukemia

Overexpression of ATP1B1 predicts an adverse prognosis in cytogenetically normal acute myeloid leukemia

https://doi.org/10.18632/oncotarget.6226

Jin-long Shi, Lin Fu, Qing Ang, Guo-jing Wang, Jun Zhu,  and Wei-dong Wang
2585-2595
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An integrated genomic approach identifies that the PI3K/AKT/FOXO pathway is involved in breast cancer tumor initiation

An integrated genomic approach identifies that the PI3K/AKT/FOXO pathway is involved in breast cancer tumor initiation

https://doi.org/10.18632/oncotarget.6354

Linda Smit, Katrien Berns, Katherine Spence, W. David Ryder, Nik Zeps, Mandy Madiredjo, Roderick Beijersbergen, René Bernards,  and Robert B. Clarke
2596-2610
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γKlotho is a novel marker and cell survival factor in a subset of triple negative breast cancers

γKlotho is a novel marker and cell survival factor in a subset of triple negative breast cancers

https://doi.org/10.18632/oncotarget.6006

Nuša Trošt, Samuel Peña-Llopis, Sajjan Koirala, Jurij Stojan, Patrick Ryan Potts, Klementina Fon Tacer,  and Elisabeth D. Martinez
2611-2628
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Novel variants in MLL confer to bladder cancer recurrence identified by whole-exome sequencing

Novel variants in MLL confer to bladder cancer recurrence identified by whole-exome sequencing

https://doi.org/10.18632/oncotarget.6380

Song Wu, Zhao Yang, Rui Ye, Dan An, Chong Li, Yitian Wang, Yongqiang Wang, Yi Huang, Huan Liu, Feida Li, Luyun He, Da Sun, Yuan Yu, Qiaoling Li, Peide Huang, Meng Zhang, Xin Zhao, Tengteng Bi, Xuehan Zhuang, Liyan Zhang, Jingxiao Lu, Xiaojuan Sun, Fangjian Zhou, Chunxiao Liu, Guosheng Yang, Yong Hou, Zusen Fan,  and Zhiming Cai
2629-2645
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

pERK/pAkt phenotyping in circulating tumor cells as a biomarker for sorafenib efficacy in patients with advanced hepatocellular carcinoma

pERK/pAkt phenotyping in circulating tumor cells as a biomarker for sorafenib efficacy in patients with advanced hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.6104

Jun Li, Lehua Shi, Xiaofeng Zhang, Bin Sun, Yefa Yang, Naijian Ge, Huiying Liu, Xia Yang, Lei Chen, Haihua Qian, Mengchao Wu,  and Zhengfeng Yin
2646-2659
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MicroRNA-497 inhibits tumor growth and increases chemosensitivity to 5-fluorouracil treatment by targeting KSR1

MicroRNA-497 inhibits tumor growth and increases chemosensitivity to 5-fluorouracil treatment by targeting KSR1

https://doi.org/10.18632/oncotarget.6545

Lin Wang, Cheng-fei Jiang, Dong-mei Li, Xin Ge, Zhu-mei Shi, Chong-yong Li, Xue Liu, Yu Yin, Linlin Zhen, Ling-Zhi Liu,  and Bing-Hua Jiang
2660-2671
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

miR-192, a prognostic indicator, targets the SLC39A6/SNAIL pathway to reduce tumor metastasis in human hepatocellular carcinoma

miR-192, a prognostic indicator, targets the SLC39A6/SNAIL pathway to reduce tumor metastasis in human hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.6603

Junwei Lian, Ying Jing, Qiongzhu Dong, Lin Huan, Di Chen, Chunyang Bao, Qifeng Wang, Fangyu Zhao, Jinjun Li, Ming Yao, Lunxiu Qin, Linhui Liang,  and Xianghuo He
2672-2683
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STB-HO, a novel mica fine particle, inhibits the teratoma-forming ability of human embryonic stem cells after in vivo transplantation

STB-HO, a novel mica fine particle, inhibits the teratoma-forming ability of human embryonic stem cells after in vivo transplantation

https://doi.org/10.18632/oncotarget.6472

Soon Won Choi, Tae-Hoon Shin, Md. Hafiz Uddin, Ji-Hee Shin, Tae-Wook Kang, Byung-Chul Lee, Hyung-Sik Kim, Yoojin Seo, Sulaiman Shams, Yeon-Kwon Jung,  and Kyung-Sun Kang
2684-2695
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Mutations in epigenetic regulators are involved in acute lymphoblastic leukemia relapse following allogeneic hematopoietic stem cell transplantation

Mutations in epigenetic regulators are involved in acute lymphoblastic leukemia relapse following allogeneic hematopoietic stem cell transplantation

https://doi.org/10.18632/oncotarget.6259

Haowen Xiao, Li-Mengmeng Wang, Yi Luo, Xiaoyu Lai, Caihua Li, Jimin Shi, Yamin Tan, Shan Fu, Yebo Wang, Ni Zhu, Jingsong He, Weiyan Zheng, Xiaohong Yu, Zhen Cai,  and He Huang
2696-2708
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

microRNA-342-5p and miR-608 inhibit colon cancer tumorigenesis by targeting NAA10

microRNA-342-5p and miR-608 inhibit colon cancer tumorigenesis by targeting NAA10

https://doi.org/10.18632/oncotarget.6458

Hongju Yang, Qian Li, Jie Niu, Bai Li, Dejun Jiang, Zhihua Wan, Qingmei Yang, Fei Jiang, Ping Wei,  and Song Bai
2709-2720
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The BIM deletion polymorphism: A paradigm of a permissive interaction between germline and acquired TKI resistance factors in chronic myeloid leukemia

The BIM deletion polymorphism: A paradigm of a permissive interaction between germline and acquired TKI resistance factors in chronic myeloid leukemia

https://doi.org/10.18632/oncotarget.5436

Tun Kiat Ko, Hui San Chin, Charles T.H. Chuah, John W.J. Huang, King-Pan Ng, Seong Lin Khaw, David C.S. Huang,  and S. Tiong Ong
2721-2733
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Combinatorial drug screening and molecular profiling reveal diverse mechanisms of intrinsic and adaptive resistance to BRAF inhibition in V600E BRAF mutant melanomas

Combinatorial drug screening and molecular profiling reveal diverse mechanisms of intrinsic and adaptive resistance to BRAF inhibition in V600E BRAF mutant melanomas

https://doi.org/10.18632/oncotarget.6548

Devin G. Roller, Brian Capaldo, Stefan Bekiranov, Aaron J. Mackey, Mark R. Conaway, Emanuel F. Petricoin, Daniel Gioeli,  and Michael J. Weber
2734-2753
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

An epigenetic biomarker combination of PCDH17 and POU4F2 detects bladder cancer accurately by methylation analyses of urine sediment DNA in Han Chinese

An epigenetic biomarker combination of PCDH17 and POU4F2 detects bladder cancer accurately by methylation analyses of urine sediment DNA in Han Chinese

https://doi.org/10.18632/oncotarget.6666

Yongqiang Wang, Yuan Yu, Rui Ye, Duo Zhang, Qiaoling Li, Dan An, Lu Fang, Youcheng Lin, Yong Hou, Abai Xu, Yu Fu, Wei Lu, Xin Chen, Mingwei Chen, Meng Zhang, Huiling Jiang, Chuanxia Zhang, Pei Dong, Chong Li, Jun Chen, Guosheng Yang, Chunxiao Liu, Zhiming Cai, Fangjian Zhou,  and Song Wu
2754-2764
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Ibrutinib synergizes with poly(ADP-ribose) glycohydrolase inhibitors to induce cell death in AML cells via a BTK-independent mechanism

Ibrutinib synergizes with poly(ADP-ribose) glycohydrolase inhibitors to induce cell death in AML cells via a BTK-independent mechanism

https://doi.org/10.18632/oncotarget.6409

Lianne E. Rotin, Marcela Gronda, Neil MacLean, Rose Hurren, XiaoMing Wang, Feng-Hsu Lin, Jeff Wrana, Alessandro Datti, Dwayne L. Barber, Mark D. Minden, Malik Slassi,  and Aaron D. Schimmer
2765-2779
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In silico pathway analysis in cervical carcinoma reveals potential new targets for treatment

In silico pathway analysis in cervical carcinoma reveals potential new targets for treatment

https://doi.org/10.18632/oncotarget.6667

Pieter-Jan H. H. van Dam, Christian Rolfo, Marco Giallombardo, Christophe van Berckelaer, Xuan Bich Trinh, Sevilay Altintas, Manon Huizing, Kostas Papadimitriou, Wiebren A. A. Tjalma,  and Steven van Laere
2780-2795
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Two clinical drugs deubiquitinase inhibitor auranofin and aldehyde dehydrogenase inhibitor disulfiram trigger synergistic anti-tumor effects in vitro and in vivo

Two clinical drugs deubiquitinase inhibitor auranofin and aldehyde dehydrogenase inhibitor disulfiram trigger synergistic anti-tumor effects in vitro and in vivo

https://doi.org/10.18632/oncotarget.6425

Hongbiao Huang, Yuning Liao, Ningning Liu, Xianliang Hua, Jianyu Cai, Changshan Yang, Huidan Long, Chong Zhao, Xin Chen, Xiaoying Lan, Dan Zang, Jinjie Wu, Xiaofen Li, Xianping Shi, Xuejun Wang,  and Jinbao Liu
2796-2808
Abstract  |  PDF  |  HTML  |  Order a Reprint

Ulocuplumab (BMS-936564 / MDX1338): a fully human anti-CXCR4 antibody induces cell death in chronic lymphocytic leukemia mediated through a reactive oxygen species-dependent pathway

Ulocuplumab (BMS-936564 / MDX1338): a fully human anti-CXCR4 antibody induces cell death in chronic lymphocytic leukemia mediated through a reactive oxygen species-dependent pathway

https://doi.org/10.18632/oncotarget.6465

Manoj K. Kashyap, Deepak Kumar, Harrison Jones, Carlos I. Amaya-Chanaga, Michael Y. Choi, Johanna Melo-Cardenas, Amine Ale-Ali, Michelle R. Kuhne, Peter Sabbatini, Lewis J. Cohen, Suresh G. Shelat, Laura Z. Rassenti, Thomas J. Kipps, Pina M. Cardarelli,  and Januario E. Castro
2809-2822
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

UBE4B targets phosphorylated p53 at serines 15 and 392 for degradation

UBE4B targets phosphorylated p53 at serines 15 and 392 for degradation

https://doi.org/10.18632/oncotarget.6555

Cheng Du, Hong Wu,  and Roger P. Leng
2823-2836
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Interferon-γ-induced p27KIP1 binds to and targets MYC for proteasome-mediated degradation

Interferon-γ-induced p27KIP1 binds to and targets MYC for proteasome-mediated degradation

https://doi.org/10.18632/oncotarget.6693

Fuad Bahram, Per Hydbring, Susanna Tronnersjö, Siti Mariam Zakaria, Oliver Frings, Sara Fahlén, Helén Nilsson, Jacob Goodwin, Natalie von der Lehr, Yingtao Su, Bernhard Lüscher, Alina Castell,  and Lars-Gunnar Larsson
2837-2854
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Biocompatible and colloidally stabilized mPEG-PE/calcium phosphate hybrid nanoparticles loaded with siRNAs targeting tumors

Biocompatible and colloidally stabilized mPEG-PE/calcium phosphate hybrid nanoparticles loaded with siRNAs targeting tumors

https://doi.org/10.18632/oncotarget.6428

Pei Gao, Xiangyu Zhang, Hongzhi Wang, Qinghong Zhang, He Li, Yaogang Li,  and Yourong Duan
2855-2866
Abstract  |  PDF  |  HTML  |  Order a Reprint

Inferring the progression of multifocal liver cancer from spatial and temporal genomic heterogeneity

Inferring the progression of multifocal liver cancer from spatial and temporal genomic heterogeneity

https://doi.org/10.18632/oncotarget.6558

Jie-Yi Shi, Qingfeng Xing, Meng Duan, Zhi-Chao Wang, Liu-Xiao Yang, Ying-Jun Zhao, Xiao-Ying Wang, Yun Liu, Minghua Deng, Zhen-Bin Ding, Ai-Wu Ke, Jian Zhou, Jia Fan, Ya Cao, Jiping Wang, Ruibin Xi,  and Qiang Gao
2867-2877
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

TLE4 promotes colorectal cancer progression through activation of JNK/c-Jun signaling pathway

TLE4 promotes colorectal cancer progression through activation of JNK/c-Jun signaling pathway

https://doi.org/10.18632/oncotarget.6694

Shu-Yang Wang, Ke Gao, Dan-Ling Deng, Juan-Juan Cai, Zhi-Yuan Xiao, Liu-Qing He, Hong-Li Jiao, Ya-Ping Ye, Run-Wei Yang, Ting-Ting Li, Li Liang, Wen-Ting Liao,  and Yan-Qing Ding
2878-2888
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Oncogene- and drug resistance-associated alternative exon usage in acute myeloid leukemia (AML)

Oncogene- and drug resistance-associated alternative exon usage in acute myeloid leukemia (AML)

https://doi.org/10.18632/oncotarget.3898

Aminetou Mint Mohamed, Marie Balsat, Morgan Thenoz, Catherine Koering, Lea Payen-Gay, Meyling Cheok, Hussein Mortada, Didier Auboeuf, Christiane Pinatel, Mohamed El-Hamri, Charles Dumontet, Emeline Cros, Pascale Flandrin-Gresta, Olivier Nibourel, Claude Preudhomme, Mauricette Michallet, Xavier Thomas, Franck Nicolini, Françoise Solly, Denis Guyotat, Lydia Campos, Eric Wattel,  and Franck Mortreux
2889-2909
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Inhibition of the pentose phosphate pathway by dichloroacetate unravels a missing link between aerobic glycolysis and cancer cell proliferation

Inhibition of the pentose phosphate pathway by dichloroacetate unravels a missing link between aerobic glycolysis and cancer cell proliferation

https://doi.org/10.18632/oncotarget.6272

Géraldine De Preter, Marie-Aline Neveu, Pierre Danhier, Lucie Brisson, Valéry L. Payen, Paolo E. Porporato, Bénédicte F. Jordan, Pierre Sonveaux,  and Bernard Gallez
2910-2920
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The erbB3- and IGF-1 receptor-initiated signaling pathways exhibit distinct effects on lapatinib sensitivity against trastuzumab-resistant breast cancer cells

The erbB3- and IGF-1 receptor-initiated signaling pathways exhibit distinct effects on lapatinib sensitivity against trastuzumab-resistant breast cancer cells

https://doi.org/10.18632/oncotarget.6404

Hui Lyu, XiaoHe Yang, Susan M. Edgerton, Ann D. Thor, Xiaoying Wu, Zhimin He,  and Bolin Liu
2921-2935
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The Toll-like receptor 5 agonist entolimod suppresses hepatic metastases in a murine model of ocular melanoma via an NK cell-dependent mechanism

The Toll-like receptor 5 agonist entolimod suppresses hepatic metastases in a murine model of ocular melanoma via an NK cell-dependent mechanism

https://doi.org/10.18632/oncotarget.6500

Hua Yang, Craig M. Brackett, Vanessa Marie Morales-Tirado, Zezhong Li, Qing Zhang, Matthew W. Wilson, Camille Benjamin, Wayne Harris, Edmund K. Waller, Andrei V. Gudkov, Lyudmila G. Burdelya,  and Hans E. Grossniklaus
2936-2950
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Expression and function of lysophosphatidic acid receptors (LPARs) 1 and 3 in human hepatic cancer progenitor cells

Expression and function of lysophosphatidic acid receptors (LPARs) 1 and 3 in human hepatic cancer progenitor cells

https://doi.org/10.18632/oncotarget.6696

Valentina Zuckerman, Eugene Sokolov, Jacob H. Swet, William A. Ahrens, Victor Showlater, David A. Iannitti,  and Iain H. Mckillop
2951-2967
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Antitumor effect of combined NAMPT and CD73 inhibition in an ovarian cancer model

Antitumor effect of combined NAMPT and CD73 inhibition in an ovarian cancer model

https://doi.org/10.18632/oncotarget.6502

Giovanna Sociali, Lizzia Raffaghello, Mirko Magnone, Federica Zamporlini, Laura Emionite, Laura Sturla, Giovanna Bianchi, Tiziana Vigliarolo, Aimable Nahimana, Alessio Nencioni, Nadia Raffaelli,  and Santina Bruzzone
2968-2984
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Melatonin inhibits AP-2β/hTERT, NF-κB/COX-2 and Akt/ERK and activates caspase/Cyto C signaling to enhance the antitumor activity of berberine in lung cancer cells

Melatonin inhibits AP-2β/hTERT, NF-κB/COX-2 and Akt/ERK and activates caspase/Cyto C signaling to enhance the antitumor activity of berberine in lung cancer cells

https://doi.org/10.18632/oncotarget.6407

Jian-Jun Lu, Lingyi Fu, Zhipeng Tang, Changlin Zhang, Lijun Qin, Jingshu Wang, Zhenlong Yu, Dingbo Shi, Xiangsheng Xiao, Fangyun Xie, Wenlin Huang,  and Wuguo Deng
2985-3001
Abstract  |  PDF  |  HTML  |  Order a Reprint

Towards understanding the breast cancer epigenome: a comparison of genome-wide DNA methylation and gene expression data

Towards understanding the breast cancer epigenome: a comparison of genome-wide DNA methylation and gene expression data

https://doi.org/10.18632/oncotarget.6503

Sandeep K. Singhal, Nawaid Usmani, Stefan Michiels, Otto Metzger-Filho, Kamal S. Saini, Olga Kovalchuk,  and Matthew Parliament
3002-3017
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

NDN is an imprinted tumor suppressor gene that is downregulated in ovarian cancers through genetic and epigenetic mechanisms

NDN is an imprinted tumor suppressor gene that is downregulated in ovarian cancers through genetic and epigenetic mechanisms

https://doi.org/10.18632/oncotarget.6576

Hailing Yang, Partha Das, Yinhua Yu, Weiqun Mao, Yan Wang, Keith Baggerly, Ying Wang, Rebecca T. Marquez, Anuja Bedi, Jinsong Liu, David Fishman, Zhen Lu,  and Robert C. Bast, Jr.
3018-3032
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Novel evidence that pituitary gonadotropins directly stimulate human leukemic cells-studies of myeloid cell lines and primary patient AML and CML cells

Novel evidence that pituitary gonadotropins directly stimulate human leukemic cells-studies of myeloid cell lines and primary patient AML and CML cells

https://doi.org/10.18632/oncotarget.6698

Ahmed Abdelbaset-Ismail, Sylwia Borkowska, Anna Janowska-Wieczorek, Torsten Tonn, Cesar Rodriguez, Marcin Moniuszko, Lukasz Bolkun, Janusz Koloczko, Andrzej Eljaszewicz, Janina Ratajczak, Mariusz Z. Ratajczak,  and Magda Kucia
3033-3046
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

miR-16 targets fibroblast growth factor 2 to inhibit NPC cell proliferation and invasion via PI3K/AKT and MAPK signaling pathways

miR-16 targets fibroblast growth factor 2 to inhibit NPC cell proliferation and invasion via PI3K/AKT and MAPK signaling pathways

https://doi.org/10.18632/oncotarget.6504

Qingmei He, Xianyue Ren, Jiewei Chen, Yingqin Li, Xinran Tang, Xin Wen, Xiaojing Yang, Jian Zhang, Yaqin Wang, Jun Ma,  and Na Liu
3047-3058
Abstract  |  PDF  |  HTML  |  Order a Reprint

Intraoperative imaging identifies thymoma margins following neoadjuvant chemotherapy

Intraoperative imaging identifies thymoma margins following neoadjuvant chemotherapy

https://doi.org/10.18632/oncotarget.6578

Jane J. Keating, Sarah Nims, Ollin Venegas, Jack Jiang, David Holt, John C. Kucharczuk, Charuhas Deshpande,  and Sunil Singhal
3059-3067
Abstract  |  PDF  |  HTML  |  Order a Reprint

Identification of a novel HER3 activating mutation homologous to EGFR-L858R in lung cancer

Identification of a novel HER3 activating mutation homologous to EGFR-L858R in lung cancer

https://doi.org/10.18632/oncotarget.6585

Ijeoma Umelo, Amir Noeparast, Gang Chen, Marleen Renard, Caroline Geers, Johan Vansteenkiste, Philippe Giron, Olivier De Wever, Erik Teugels,  and Jacques De Grève
3068-3083
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Epigenetic inactivation of the putative DNA/RNA helicase SLFN11 in human cancer confers resistance to platinum drugs

Epigenetic inactivation of the putative DNA/RNA helicase SLFN11 in human cancer confers resistance to platinum drugs

https://doi.org/10.18632/oncotarget.6413

Vanesa Nogales, William C. Reinhold, Sudhir Varma, Anna Martinez-Cardus, Catia Moutinho, Sebastian Moran, Holger Heyn, Ana Sebio, Agusti Barnadas, Yves Pommier,  and Manel Esteller
3084-3097
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Annexin-A1 and caldesmon are associated with resistance to tamoxifen in estrogen receptor positive recurrent breast cancer

Annexin-A1 and caldesmon are associated with resistance to tamoxifen in estrogen receptor positive recurrent breast cancer

https://doi.org/10.18632/oncotarget.6521

Tommaso De Marchi, Anne M. Timmermans, Marcel Smid, Maxime P. Look, Christoph Stingl, Mark Opdam, Sabine C. Linn, Fred C. G. J. Sweep, Paul N. Span, Mike Kliffen, Carolien H. M. van Deurzen, Theo M. Luider, John A. Foekens, John W. Martens,  and Arzu Umar
3098-3110
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Oxidative stress induces the acquisition of cancer stem-like phenotype in breast cancer detectable by using a Sox2 regulatory region-2 (SRR2) reporter

Oxidative stress induces the acquisition of cancer stem-like phenotype in breast cancer detectable by using a Sox2 regulatory region-2 (SRR2) reporter

https://doi.org/10.18632/oncotarget.6630

Keshav Gopal, Nidhi Gupta, Haifeng Zhang, Abdulraheem Alshareef, Hind Alqahtani, Gilbert Bigras, Jamie Lewis, Donna Douglas, Norman Kneteman, Afsaneh Lavasanifar,  and Raymond Lai
3111-3127
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Tumor suppressor BTG1 promotes PRMT1-mediated ATF4 function in response to cellular stress

Tumor suppressor BTG1 promotes PRMT1-mediated ATF4 function in response to cellular stress

https://doi.org/10.18632/oncotarget.6519

Laurensia Yuniati, Laurens T. van der Meer, Esther Tijchon, Dorette van Ingen Schenau, Liesbeth van Emst, Marloes Levers, Sander A.L. Palit, Caroline Rodenbach, Geert Poelmans, Peter M. Hoogerbrugge, Jixiu Shan, Michael S. Kilberg, Blanca Scheijen,  and Frank N. van Leeuwen
3128-3143
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A novel PAD4/SOX4/PU.1 signaling pathway is involved in the committed differentiation of acute promyelocytic leukemia cells into granulocytic cells

A novel PAD4/SOX4/PU.1 signaling pathway is involved in the committed differentiation of acute promyelocytic leukemia cells into granulocytic cells

https://doi.org/10.18632/oncotarget.6551

Guanhua Song, Lulu Shi, Yuqi Guo, Linchang Yu, Lin Wang, Xiaoyu Zhang, Lianlian Li, Yang Han, Xia Ren, Qiang Guo, Kehong Bi,  and Guosheng Jiang
3144-3157
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Mps1 is SUMO-modified during the cell cycle

Mps1 is SUMO-modified during the cell cycle

https://doi.org/10.18632/oncotarget.6552

Agnese Restuccia, Feikun Yang, Changyan Chen, Lou Lu,  and Wei Dai
3158-3170
Abstract  |  PDF  |  HTML  |  Order a Reprint

Antibiotic drug tigecycline inhibits melanoma progression and metastasis in a p21CIP1/Waf1-dependent manner

Antibiotic drug tigecycline inhibits melanoma progression and metastasis in a p21CIP1/Waf1-dependent manner

https://doi.org/10.18632/oncotarget.6419

Huanrong Hu, Zhen Dong, Peng Tan, Yanli Zhang, Lichao Liu, Liqun Yang, Yaling Liu,  and Hongjuan Cui
3171-3185
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Combination of Tolfenamic acid and curcumin induces colon cancer cell growth inhibition through modulating specific transcription factors and reactive oxygen species

Combination of Tolfenamic acid and curcumin induces colon cancer cell growth inhibition through modulating specific transcription factors and reactive oxygen species

https://doi.org/10.18632/oncotarget.6553

Umesh T. Sankpal, Ganji Purnachandra Nagaraju, Sriharika R. Gottipolu, Myrna Hurtado, Christopher G. Jordan, Jerry W. Simecka, Mamoru Shoji, Bassel El- Rayes,  and Riyaz Basha
3186-3200
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Luminal long non-coding RNAs regulated by estrogen receptor alpha in a ligand-independent manner show functional roles in breast cancer

Luminal long non-coding RNAs regulated by estrogen receptor alpha in a ligand-independent manner show functional roles in breast cancer

https://doi.org/10.18632/oncotarget.6420

Valentina Miano, Giulio Ferrero, Stefania Reineri, Livia Caizzi, Laura Annaratone, Laura Ricci, Santina Cutrupi, Isabella Castellano, Francesca Cordero,  and Michele De Bortoli
3201-3216
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Quinomycin A targets Notch signaling pathway in pancreatic cancer stem cells

Quinomycin A targets Notch signaling pathway in pancreatic cancer stem cells

https://doi.org/10.18632/oncotarget.6560

Sivapriya Ponnurangam, Prasad R. Dandawate, Animesh Dhar, Ossama W. Tawfik, Rajashri R. Parab, Prabhu Dutt Mishra, Prafull Ranadive, Rajiv Sharma, Girish Mahajan, Shahid Umar, Scott J. Weir, Aravind Sugumar, Roy A. Jensen, Subhash B. Padhye, Arun Balakrishnan, Shrikant Anant,  and Dharmalingam Subramaniam
3217-3232
Abstract  |  PDF  |  HTML  |  Order a Reprint

Sphingosine kinase 1 is overexpressed and promotes adrenocortical carcinoma progression

Sphingosine kinase 1 is overexpressed and promotes adrenocortical carcinoma progression

https://doi.org/10.18632/oncotarget.6564

Yunze Xu, Baijun Dong, Jiwei Huang, Wen Kong, Wei Xue, Yu Zhu, Jin Zhang,  and Yiran Huang
3233-3244
Abstract  |  PDF  |  HTML  |  Order a Reprint

A chemotherapy response classifier based on support vector machines for high-grade serous ovarian carcinoma

A chemotherapy response classifier based on support vector machines for high-grade serous ovarian carcinoma

https://doi.org/10.18632/oncotarget.6569

Chao-Yang Sun, Tie-Fen Su, Na Li, Bo Zhou, En-Song Guo, Zong-Yuan Yang, Jing Liao, Dong Ding, Qin Xu, Hao Lu, Li Meng, Shi-Xuan Wang, Jian-Feng Zhou, Hui Xing, Dan-Hui Weng, Ding Ma,  and Gang Chen
3245-3254
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Direct quantitative detection for cell-free miR-155 in urine: a potential role in diagnosis and prognosis for non-muscle invasive bladder cancer

Direct quantitative detection for cell-free miR-155 in urine: a potential role in diagnosis and prognosis for non-muscle invasive bladder cancer

https://doi.org/10.18632/oncotarget.6487

Xin Zhang, Yanli Zhang, Xinfeng Liu, Aiju Fang, Jinfeng Wang, Yongmei Yang, Lili Wang, Lutao Du,  and Chuanxin Wang
3255-3266
Abstract  |  PDF  |  HTML  |  Order a Reprint

Artemin is hypoxia responsive and promotes oncogenicity and increased tumor initiating capacity in hepatocellular carcinoma

Artemin is hypoxia responsive and promotes oncogenicity and increased tumor initiating capacity in hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.6572

Min Zhang, Weijie Zhang, Zhengsheng Wu, Shumin Liu, Linchong Sun, Yanghao Zhong, Xiao Zhang, Xiangjun Kong, Pengxu Qian, Huafeng Zhang, Peter E. Lobie,  and Tao Zhu
3267-3282
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Tumor suppressor REIC/DKK-3 and co-chaperone SGTA: Their interaction and roles in the androgen sensitivity

Tumor suppressor REIC/DKK-3 and co-chaperone SGTA: Their interaction and roles in the androgen sensitivity

https://doi.org/10.18632/oncotarget.6488

Kazuhiko Ochiai, Masami Morimatsu, Yuiko Kato, Toshina Ishiguro-Oonuma, Chihiro Udagawa, Oumaporn Rungsuriyawiboon, Daigo Azakami, Masaki Michishita, Yuichi Ariyoshi, Hideo Ueki, Yasutomo Nasu, Hiromi Kumon, Masami Watanabe,  and Toshinori Omi
3283-3296
Abstract  |  PDF  |  HTML  |  Order a Reprint

Unique roles of Akt1 and Akt2 in IGF-IR mediated lung tumorigenesis

Unique roles of Akt1 and Akt2 in IGF-IR mediated lung tumorigenesis

https://doi.org/10.18632/oncotarget.6489

Elizabeth S. Franks, Ritesh Briah, Robert A. Jones,  and Roger A. Moorehead
3297-3316
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Overexpression of PD2 leads to increased tumorigenicity and metastasis in pancreatic ductal adenocarcinoma

Overexpression of PD2 leads to increased tumorigenicity and metastasis in pancreatic ductal adenocarcinoma

https://doi.org/10.18632/oncotarget.6580

Arokia Priyanka Vaz, Shonali Deb, Satyanarayana Rachagani, Parama Dey, Sakthivel Muniyan, Imayavaramban Lakshmanan, Saswati Karmakar, Lynette Smith, Sonny Johansson, Subodh Lele, Michel Ouellette, Moorthy P. Ponnusamy,  and Surinder K. Batra
3317-3331
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Prognostic significance of FAM83D gene expression across human cancer types

Prognostic significance of FAM83D gene expression across human cancer types

https://doi.org/10.18632/oncotarget.6620

Peter J. Walian, Bo Hang,  and Jian-Hua Mao
3332-3340
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Inhibition of hypoxia inducible factor 1 and topoisomerase with acriflavine sensitizes perihilar cholangiocarcinomas to photodynamic therapy

Inhibition of hypoxia inducible factor 1 and topoisomerase with acriflavine sensitizes perihilar cholangiocarcinomas to photodynamic therapy

https://doi.org/10.18632/oncotarget.6490

Ruud Weijer, Mans Broekgaarden, Massis Krekorian, Lindy K. Alles, Albert C. van Wijk, Claire Mackaaij, Joanne Verheij, Allard C. van der Wal, Thomas M. van Gulik, Gert Storm,  and Michal Heger
3341-3356
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Detection of EpCAM-positive microparticles in pleural fluid: A new approach to mini-invasively identify patients with malignant pleural effusions

Detection of EpCAM-positive microparticles in pleural fluid: A new approach to mini-invasively identify patients with malignant pleural effusions

https://doi.org/10.18632/oncotarget.6581

Elisa Roca, Romaric Lacroix, Coralie Judicone, Sophie Laroumagne, Stéphane Robert, Sylvie Cointe, Alexandre Muller, Elise Kaspi, Patrice Roll, Alain R. Brisson, Claudio Tantucci, Philippe Astoul,  and Françoise Dignat-George
3357-3366
Abstract  |  PDF  |  HTML  |  Order a Reprint

EGFR kinase domain mutation positive lung cancers are sensitive to intrapleural perfusion with hyperthermic chemotherapy (IPHC) complete treatment

EGFR kinase domain mutation positive lung cancers are sensitive to intrapleural perfusion with hyperthermic chemotherapy (IPHC) complete treatment

https://doi.org/10.18632/oncotarget.6491

Hongjuan Zhang, Cheng Zhan, Ji Ke, Zhiqiang Xue, Aiqun Zhang, Kaifeng Xu, Zhirong Shen, Lei Yu,  and Liang Chen
3367-3378
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Monoamine oxidase B levels are highly expressed in human gliomas and are correlated with the expression of HiF-1α and with transcription factors Sp1 and Sp3

Monoamine oxidase B levels are highly expressed in human gliomas and are correlated with the expression of HiF-1α and with transcription factors Sp1 and Sp3

https://doi.org/10.18632/oncotarget.6582

Martyn A. Sharpe,  and David S. Baskin
3379-3393
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Regulatory T cells may participate in Helicobacter pylori persistence in gastric MALT lymphoma: lessons from an animal model

Regulatory T cells may participate in Helicobacter pylori persistence in gastric MALT lymphoma: lessons from an animal model

https://doi.org/10.18632/oncotarget.6492

Amandine Marine Laur, Pauline Floch, Lucie Chambonnier, Lucie Benejat, Victoria Korolik, Alban Giese, Pierre Dubus, Francis Mégraud, Antonio Bandeira,  and Philippe Lehours
3394-3402
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Mutational landscape of MCPyV-positive and MCPyV-negative Merkel cell carcinomas with implications for immunotherapy

Mutational landscape of MCPyV-positive and MCPyV-negative Merkel cell carcinomas with implications for immunotherapy

https://doi.org/10.18632/oncotarget.6494

Gerald Goh, Trent Walradt, Vladimir Markarov, Astrid Blom, Nadeem Riaz, Ryan Doumani, Krista Stafstrom, Ata Moshiri, Lola Yelistratova, Jonathan Levinsohn, Timothy A. Chan, Paul Nghiem, Richard P. Lifton,  and Jaehyuk Choi
3403-3415
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Involvement of Nrf2 in proteasome inhibition-mediated induction of ORP150 in thyroid cancer cells

Involvement of Nrf2 in proteasome inhibition-mediated induction of ORP150 in thyroid cancer cells

https://doi.org/10.18632/oncotarget.6636

Zhi-Hong Zong, Zhen-Xian Du, Hai-Yan Zhang, Chao Li, Ming-Xin An, Si Li, Han-Bing Yao,  and Hua-Qin Wang
3416-3426
Abstract  |  PDF  |  HTML  |  Order a Reprint

Obg-like ATPase 1 regulates global protein serine/threonine phosphorylation in cancer cells by suppressing the GSK3β-inhibitor 2-PP1 positive feedback loop

Obg-like ATPase 1 regulates global protein serine/threonine phosphorylation in cancer cells by suppressing the GSK3β-inhibitor 2-PP1 positive feedback loop

https://doi.org/10.18632/oncotarget.6496

Dong Xu, Renduo Song, Guohui Wang, Prince V.S. Jeyabal, Amanda M. Weiskoff, Kefeng Ding,  and Zheng-Zheng Shi
3427-3439
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Inhibition of EZH2 by chemo- and radiotherapy agents and small molecule inhibitors induces cell death in castration-resistant prostate cancer

Inhibition of EZH2 by chemo- and radiotherapy agents and small molecule inhibitors induces cell death in castration-resistant prostate cancer

https://doi.org/10.18632/oncotarget.6497

Changping Wu, Xin Jin, Jing Yang, Yinhui Yang, Yundong He, Liya Ding, Yunqian Pan, Shuai Chen, Jingting Jiang,  and Haojie Huang
3440-3452
Abstract  |  PDF  |  HTML  |  Order a Reprint

HER2 genomic amplification in circulating tumor DNA from patients with cetuximab-resistant colorectal cancer

HER2 genomic amplification in circulating tumor DNA from patients with cetuximab-resistant colorectal cancer

https://doi.org/10.18632/oncotarget.6498

Naoki Takegawa, Kimio Yonesaka, Kazuko Sakai, Hiroto Ueda, Satomi Watanabe, Yoshikane Nonagase, Tatsuya Okuno, Masayuki Takeda, Osamu Maenishi, Junji Tsurutani, Taroh Satoh, Isamu Okamoto, Kazuto Nishio, Takao Tamura,  and Kazuhiko Nakagawa
3453-3460
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Molecular evidence of Zn chelation of the procaspase activating compound B-PAC-1 in B cell lymphoma

Molecular evidence of Zn chelation of the procaspase activating compound B-PAC-1 in B cell lymphoma

https://doi.org/10.18632/oncotarget.6505

Aloke Sarkar, Kumudha Balakrishnan, Jefferson Chen, Viralkumar Patel, Sattva S. Neelapu, John S. McMurray,  and Varsha Gandhi
3461-3476
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The positive prognostic effect of stromal CD8+ tumor-infiltrating T cells is restrained by the expression of HLA-E in non-small cell lung carcinoma

The positive prognostic effect of stromal CD8+ tumor-infiltrating T cells is restrained by the expression of HLA-E in non-small cell lung carcinoma

https://doi.org/10.18632/oncotarget.6506

Mehrdad Talebian Yazdi, Sander van Riet, Annemarie van Schadewijk, Marta Fiocco, Thorbald van Hall, Christian Taube, Pieter S. Hiemstra,  and Sjoerd H. van der burg
3477-3488
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Chronic ethanol exposure enhances the aggressiveness of breast cancer: the role of p38γ

Chronic ethanol exposure enhances the aggressiveness of breast cancer: the role of p38γ

https://doi.org/10.18632/oncotarget.6508

Mei Xu, Siying Wang, Zhenhua Ren, Jacqueline A. Frank, Xiuwei H. Yang, Zhuo Zhang, Zun-ji Ke, Xianglin Shi,  and Jia Luo
3489-3505
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FOXP1 functions as an oncogene in promoting cancer stem cell-like characteristics in ovarian cancer cells

FOXP1 functions as an oncogene in promoting cancer stem cell-like characteristics in ovarian cancer cells

https://doi.org/10.18632/oncotarget.6510

Eun Jung Choi, Eun Jin Seo, Dae Kyoung Kim, Su In Lee, Yang Woo Kwon, Il Ho Jang, Ki-Hyung Kim, Dong-Soo Suh,  and Jae Ho Kim
3506-3519
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Selective targeting of BCL6 induces oncogene addiction switching to BCL2 in B-cell lymphoma

Selective targeting of BCL6 induces oncogene addiction switching to BCL2 in B-cell lymphoma

https://doi.org/10.18632/oncotarget.6513

Thibault Dupont, ShaoNing Yang, Jayeshkumar Patel, Katerina Hatzi, Alka Malik, Wayne Tam, Peter Martin, John Leonard, Ari Melnick,  and Leandro Cerchietti
3520-3532
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Gamabufotalin, a major derivative of bufadienolide, inhibits VEGF-induced angiogenesis by suppressing VEGFR-2 signaling pathway

Gamabufotalin, a major derivative of bufadienolide, inhibits VEGF-induced angiogenesis by suppressing VEGFR-2 signaling pathway

https://doi.org/10.18632/oncotarget.6514

Ning Tang, Lei Shi, Zhenlong Yu, Peipei Dong, Chao Wang, Xiaokui Huo, Baojing Zhang, Shanshan Huang, Sa Deng, Kexin Liu, Tonghui Ma, Xiaobo Wang, Lijun Wu,  and Xiaochi Ma
3533-3547
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Auranofin-mediated inhibition of PI3K/AKT/mTOR axis and anticancer activity in non-small cell lung cancer cells

Auranofin-mediated inhibition of PI3K/AKT/mTOR axis and anticancer activity in non-small cell lung cancer cells

https://doi.org/10.18632/oncotarget.6516

Hongyu Li, Jing Hu, Shuhong Wu, Li Wang, Xiaobo Cao, Xiaoshan Zhang, Bingbing Dai, Mengru Cao, Ruping Shao, Ran Zhang, Mourad Majidi, Lin Ji, John V. Heymach, Michael Wang, Shiyang Pan, John Minna, Reza J. Mehran, Stephen G. Swisher, Jack A. Roth,  and Bingliang Fang
3548-3558
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Mitochondrial reactive oxygen species perturb AKT/cyclin D1 cell cycle signaling via oxidative inactivation of PP2A in lowdose irradiated human fibroblasts

Mitochondrial reactive oxygen species perturb AKT/cyclin D1 cell cycle signaling via oxidative inactivation of PP2A in lowdose irradiated human fibroblasts

https://doi.org/10.18632/oncotarget.6518

Tsutomu Shimura, Megumi Sasatani, Kenji Kamiya, Hidehiko Kawai, Yohei Inaba,  and Naoki Kunugita
3559-3570
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Metronomic topotecan impedes tumor growth of MYCN-amplified neuroblastoma cells in vitro and in vivo by therapy induced senescence

Metronomic topotecan impedes tumor growth of MYCN-amplified neuroblastoma cells in vitro and in vivo by therapy induced senescence

https://doi.org/10.18632/oncotarget.6527

Sabine Taschner-Mandl, Magdalena Schwarz, Johanna Blaha, Maximilian Kauer, Florian Kromp, Nelli Frank, Fikret Rifatbegovic, Tamara Weiss, Ruth Ladenstein, Martin Hohenegger, Inge M. Ambros,  and Peter F. Ambros
3571-3586
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A microRNA-based prediction model for lymph node metastasis in hepatocellular carcinoma

A microRNA-based prediction model for lymph node metastasis in hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.6534

Li Zhang, Zuo-Lin Xiang, Zhao-Chong Zeng, Jia Fan, Zhao-You Tang,  and Xiao-Mei Zhao
3587-3598
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Clinical Research Papers

Mutually exclusive mutations in NOTCH1 and PIK3CA associated with clinical prognosis and chemotherapy responses of esophageal squamous cell carcinoma in China

Mutually exclusive mutations in NOTCH1 and PIK3CA associated with clinical prognosis and chemotherapy responses of esophageal squamous cell carcinoma in China

https://doi.org/10.18632/oncotarget.6120

Bin Song, Heyang Cui, Yaoping Li, Caixia Cheng, Bin Yang, Fang Wang, Pengzhou Kong, Hongyi Li, Ling Zhang, Zhiwu Jia, Yanghui Bi, Jiaqian Wang, Yong Zhou, Jing Liu, Juan Wang, Zhenxiang Zhao, Yanyan Zhang, Xiaoling Hu, Ruyi Shi, Jie Yang, Haiyan Liu, Ting Yan, Yike Li, Enwei Xu, Yu Qian, Yanfeng Xi, Shiping Guo, Yunqing Chen, Jinfen Wang, Guodong Li, Jianfang Liang, Junmei Jia, Xing Chen, Jiansheng Guo, Tong Wang, Yanbo Zhang, Qingshan Li, Chuangui Wang, Xiaolong Cheng, Qimin Zhan,  and Yongping Cui
3599-3613
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Tolerability and efficacy of gamma knife radiosurgery on hepatocellular carcinoma with portal vein tumor thrombosis

Tolerability and efficacy of gamma knife radiosurgery on hepatocellular carcinoma with portal vein tumor thrombosis

https://doi.org/10.18632/oncotarget.6118

Xiao-Jie Lu, Jing Dong, Li-Juan Ji, Li-Xin Xiao, Chang-Quan Ling,  and Jun Zhou
3614-3622
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HAG regimen improves survival in adult patients with hypocellular acute myeloid leukemia

HAG regimen improves survival in adult patients with hypocellular acute myeloid leukemia

https://doi.org/10.18632/oncotarget.6211

Xiaoxia Hu, Weijun Fu, Libing Wang, Lei Gao, Shuqin Lü, Hao Xi, Huiying Qiu, Li Chen, Jie Chen, Xiong Ni, Xiaoqian Xu, Weiping Zhang, Jianmin Yang, Jianmin Wang,  and Xianmin Song
3623-3634
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Greater efficacy of chemotherapy plus bevacizumab compared to chemo- and targeted therapy alone on non-small cell lung cancer patients with brain metastasis

Greater efficacy of chemotherapy plus bevacizumab compared to chemo- and targeted therapy alone on non-small cell lung cancer patients with brain metastasis

https://doi.org/10.18632/oncotarget.6184

Ning Tang, Jun Guo, Qianqian Zhang, Yali Wang,  and Zhehai Wang
3635-3644
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Development of a ten-signature classifier using a support vector machine integrated approach to subdivide the M1 stage into M1a and M1b stages of nasopharyngeal carcinoma with synchronous metastases to better predict patients’ survival

Development of a ten-signature classifier using a support vector machine integrated approach to subdivide the M1 stage into M1a and M1b stages of nasopharyngeal carcinoma with synchronous metastases to better predict patients’ survival

https://doi.org/10.18632/oncotarget.6436

Rou Jiang, Rui You, Xiao-Qing Pei, Xiong Zou, Meng-Xia Zhang, Tong-Min Wang, Rui Sun, Dong-Hua Luo, Pei-Yu Huang, Qiu-Yan Chen, Yi-Jun Hua, Lin-Quan Tang, Ling Guo, Hao-Yuan Mo, Chao-Nan Qian, Hai-Qiang Mai, Ming-Huang Hong, Hong-Min Cai,  and Ming-Yuan Chen
3645-3657
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