Oncotarget

Vol 7, No 1

January 5, 2016

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Endosome and INPP4B. See Chew et al.

Table of Contents

Editorial

p75NTR in Huntington's disease: beyond the basal ganglia

p75NTR in Huntington's disease: beyond the basal ganglia

https://doi.org/10.18632/oncotarget.6646

Verónica Brito,  and Silvia Ginés
1-2
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UHRF1 is a sensor for DNA interstrand crosslinks

UHRF1 is a sensor for DNA interstrand crosslinks

https://doi.org/10.18632/oncotarget.6647

Chih-Chao Liang,  and Martin A. Cohn
3-4
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Endosome and INPP4B

Endosome and INPP4B

https://doi.org/10.18632/oncotarget.6663

Chen Li Chew, Ming Chen,  and Pier Paolo Pandolfi
5-6
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Research Papers: Gerotarget (Focus on Aging)

miR-195 in human primary mesenchymal stromal/stem cells regulates proliferation, osteogenesis and paracrine effect on angiogenesis

miR-195 in human primary mesenchymal stromal/stem cells regulates proliferation, osteogenesis and paracrine effect on angiogenesis

https://doi.org/10.18632/oncotarget.6589

Maria Ines Almeida, Andreia Machado Silva, Daniel Marques Vasconcelos, Catarina Rodrigues Almeida, Hugo Caires, Marta Teixeira Pinto, George Adrian Calin, Susana Gomes Santos,  and Mário Adolfo Barbosa
7-22
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Association study of polymorphisms in FOXO3, AKT1 and IGF-2R genes with human longevity in a Han Chinese population

Association study of polymorphisms in FOXO3, AKT1 and IGF-2R genes with human longevity in a Han Chinese population

https://doi.org/10.18632/oncotarget.6627

Ning Li, Huaichao Luo, Xiaoqi Liu, Shi Ma, He Lin, Rong Chen, Fang Hao,  and Dingding Zhang
23-32
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Identification of cardiac-related circulating microRNA profile in human chronic heart failure

Identification of cardiac-related circulating microRNA profile in human chronic heart failure

https://doi.org/10.18632/oncotarget.6631

Huaping Li, Jiahui Fan, Zhongwei Yin, Feng Wang, Chen Chen,  and Dao Wen Wang
33-45
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Replication stress induced site-specific phosphorylation targets WRN to the ubiquitin-proteasome pathway

Replication stress induced site-specific phosphorylation targets WRN to the ubiquitin-proteasome pathway

https://doi.org/10.18632/oncotarget.6659

Fengtao Su, Souparno Bhattacharya, Salim Abdisalaam, Shibani Mukherjee, Hirohiko Yajima, Yanyong Yang, Ritu Mishra, Kalayarasan Srinivasan, Subroto Ghose, David J. Chen, Steven M. Yannone,  and Aroumougame Asaithamby
46-65
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Research Papers: Pathology

Prohibitin overexpression improves myocardial function in diabetic cardiomyopathy

Prohibitin overexpression improves myocardial function in diabetic cardiomyopathy

https://doi.org/10.18632/oncotarget.6384

Wen-qian Dong, Min Chao, Qing-hua Lu, Wei-li Chai, Wei Zhang, Xue-ying Chen, Er-shun Liang, Ling-bo Wang, Hong-liang Tian, Yu-guo Chen,  and Ming-xiang Zhang
66-80
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MicroRNA-17-5p-activated Wnt/β-catenin pathway contributes to the progression of liver fibrosis

MicroRNA-17-5p-activated Wnt/β-catenin pathway contributes to the progression of liver fibrosis

https://doi.org/10.18632/oncotarget.6447

Fujun Yu, Zhongqiu Lu, Kate Huang, Xiaodong Wang, Ziqiang Xu, Bicheng Chen, Peihong Dong,  and Jianjian Zheng
81-93
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GPER is involved in the stimulatory effects of aldosterone in breast cancer cells and breast tumor-derived endothelial cells

GPER is involved in the stimulatory effects of aldosterone in breast cancer cells and breast tumor-derived endothelial cells

https://doi.org/10.18632/oncotarget.6475

Damiano Cosimo Rigiracciolo, Andrea Scarpelli, Rosamaria Lappano, Assunta Pisano, Maria Francesca Santolla, Silvia Avino, Paola De Marco, Benedetta Bussolati, Marcello Maggiolini,  and Ernestina Marianna De Francesco
94-111
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A transcribed ultraconserved noncoding RNA, Uc.173, is a key molecule for the inhibition of lead-induced neuronal apoptosis

A transcribed ultraconserved noncoding RNA, Uc.173, is a key molecule for the inhibition of lead-induced neuronal apoptosis

https://doi.org/10.18632/oncotarget.6590

Aruo Nan, Xinke Zhou, Lijian Chen, Meiling Liu, Nan Zhang, Li Zhang, Yuanwei Luo, Zhenzhong Liu, Lijun Dai,  and Yiguo Jiang
112-124
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Research Papers: Immunology

Toxic effect of NiCl2 on development of the bursa of Fabricius in broiler chickens

Toxic effect of NiCl2 on development of the bursa of Fabricius in broiler chickens

https://doi.org/10.18632/oncotarget.6591

Shuang Yin, Hengmin Cui, Xi Peng, Jing Fang, Zhicai Zuo, Junliang Deng, Xun Wang, Bangyuan Wu,  and Hongrui Guo
125-139
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18F-FDG PET imaging for identifying the dynamics of intestinal disease caused by SFTSV infection in a mouse model

18F-FDG PET imaging for identifying the dynamics of intestinal disease caused by SFTSV infection in a mouse model

https://doi.org/10.18632/oncotarget.6645

Daisuke Hayasaka, Kodai Nishi, Takeshi Fuchigami, Kazuya Shiogama, Takanori Onouchi, Satoshi Shimada, Yutaka Tsutsumi,  and Kouichi Morita
140-147
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The role of TRPV1 in the CD4+ T cell-mediated inflammatory response of allergic rhinitis

The role of TRPV1 in the CD4+ T cell-mediated inflammatory response of allergic rhinitis

https://doi.org/10.18632/oncotarget.6653

Ramachandran Samivel, Dae Woo Kim, Hye Ran Son, Yun-Hee Rhee, Eun Hee Kim, Ji Hye Kim, Jun-Sang Bae, Young-Jun Chung, Phil-Sang Chung, Eyal Raz,  and Ji-Hun Mo
148-160
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

slan/M-DC8+ cells constitute a distinct subset of dendritic cells in human tonsils

slan/M-DC8+ cells constitute a distinct subset of dendritic cells in human tonsils

https://doi.org/10.18632/oncotarget.6660

Alessandra Micheletti, Giulia Finotti, Federica Calzetti, Silvia Lonardi, Elisa Zoratti, Mattia Bugatti, Stefania Stefini, William Vermi,  and Marco A. Cassatella
161-175
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Reviews

Oncogenomic portals for the visualization and analysis of genome-wide cancer data

Oncogenomic portals for the visualization and analysis of genome-wide cancer data

https://doi.org/10.18632/oncotarget.6128

Katarzyna Klonowska, Karol Czubak, Marzena Wojciechowska, Luiza Handschuh, Agnieszka Zmienko, Marek Figlerowicz, Hanna Dams-Kozlowska,  and Piotr Kozlowski
176-192
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Prostate cancer stem cells: the role of androgen and estrogen receptors

Prostate cancer stem cells: the role of androgen and estrogen receptors

https://doi.org/10.18632/oncotarget.6220

Erika Di Zazzo, Giovanni Galasso, Pia Giovannelli, Marzia Di Donato, Annalisa Di Santi, Gustavo Cernera, Valentina Rossi, Ciro Abbondanza, Bruno Moncharmont, Antonio Agostino Sinisi, Gabriella Castoria,  and Antimo Migliaccio
193-208
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Emerging role of N-myc downstream-regulated gene 2 (NDRG2) in cancer

Emerging role of N-myc downstream-regulated gene 2 (NDRG2) in cancer

https://doi.org/10.18632/oncotarget.6228

Wei Hu, Chongxi Fan, Peng Jiang, Zhiqiang Ma, Xiaolong Yan, Shouyin Di, Shuai Jiang, Tian Li, Yedong Cheng,  and Yang Yang
209-223
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Research Papers

Virus-encoded microRNA contributes to the molecular profile of EBV-positive Burkitt lymphomas

Virus-encoded microRNA contributes to the molecular profile of EBV-positive Burkitt lymphomas

https://doi.org/10.18632/oncotarget.4399

Pier Paolo Piccaluga, Mohsen Navari, Giulia De Falco, Maria Raffaella Ambrosio, Stefano Lazzi, Fabio Fuligni, Cristiana Bellan, Maura Rossi, Maria Rosaria Sapienza, Maria Antonella Laginestra, Maryam Etebari, Emily A. Rogena, Lynnette Tumwine, Claudio Tripodo, Davide Gibellini, Jessica Consiglio, Carlo M. Croce, Stefano A. Pileri,  and Lorenzo Leoncini
224-240
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Long non-coding RNA HULC promotes tumor angiogenesis in liver cancer by up-regulating sphingosine kinase 1 (SPHK1)

Long non-coding RNA HULC promotes tumor angiogenesis in liver cancer by up-regulating sphingosine kinase 1 (SPHK1)

https://doi.org/10.18632/oncotarget.6280

Zhanping Lu, Zelin Xiao, Fabao Liu, Ming Cui, Weiping Li, Zhe Yang, Jiong Li, Lihong Ye,  and Xiaodong Zhang
241-254
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Taxanes enhance trastuzumab-mediated ADCC on tumor cells through NKG2D-mediated NK cell recognition

Taxanes enhance trastuzumab-mediated ADCC on tumor cells through NKG2D-mediated NK cell recognition

https://doi.org/10.18632/oncotarget.6353

Martina Di Modica, Lucia Sfondrini, Viola Regondi, Stefania Varchetta, Barbara Oliviero, Gabriella Mariani, Giulia Valeria Bianchi, Daniele Generali, Andrea Balsari, Tiziana Triulzi,  and Elda Tagliabue
255-265
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MicroRNA-107: a novel promoter of tumor progression that targets the CPEB3/EGFR axis in human hepatocellular carcinoma

MicroRNA-107: a novel promoter of tumor progression that targets the CPEB3/EGFR axis in human hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.5689

Chen-Dan Zou, Wei-Ming Zhao, Xiao-Na Wang, Qiang Li, Hui Huang, Wan-Peng Cheng, Jian-Feng Jin, He Zhang, Ming-Juan Wu, Sheng Tai, Chao-Xia Zou,  and Xu Gao
266-278
Abstract  |  PDF  |  HTML  |  Order a Reprint

APPL proteins promote TGFβ-induced nuclear transport of the TGFβ type I receptor intracellular domain

APPL proteins promote TGFβ-induced nuclear transport of the TGFβ type I receptor intracellular domain

https://doi.org/10.18632/oncotarget.6346

Jie Song, Yabing Mu, Chunyan Li, Anders Bergh, Marta Miaczynska, Carl-Henrik Heldin,  and Marene Landström
279-292
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

miR-671-5p inhibits epithelial-to-mesenchymal transition by downregulating FOXM1 expression in breast cancer

miR-671-5p inhibits epithelial-to-mesenchymal transition by downregulating FOXM1 expression in breast cancer

https://doi.org/10.18632/oncotarget.6344

Xiaohui Tan, Yebo Fu, Liang Chen, Woojin Lee, Yinglei Lai, Katayoon Rezaei, Sana Tabbara, Patricia Latham, Christine B. Teal, Yan-Gao Man, Robert S. Siegel, Rachel F. Brem,  and Sidney W. Fu
293-307
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Caveolin-1 regulates cancer cell metabolism via scavenging Nrf2 and suppressing MnSOD-driven glycolysis

Caveolin-1 regulates cancer cell metabolism via scavenging Nrf2 and suppressing MnSOD-driven glycolysis

https://doi.org/10.18632/oncotarget.5687

Peter C. Hart, Bianca A. Ratti, Mao Mao, Kristine Ansenberger-Fricano, Ayesha N. Shajahan-Haq, Angela L. Tyner, Richard D. Minshall,  and Marcelo G. Bonini
308-322
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Angiogenic gene signature in human pancreatic cancer correlates with TGF-beta and inflammatory transcriptomes

Angiogenic gene signature in human pancreatic cancer correlates with TGF-beta and inflammatory transcriptomes

https://doi.org/10.18632/oncotarget.6345

Kelly E. Craven, Jesse Gore, Julie L. Wilson,  and Murray Korc
323-341
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A signal processing based analysis and prediction of seizure onset in patients with epilepsy

A signal processing based analysis and prediction of seizure onset in patients with epilepsy

https://doi.org/10.18632/oncotarget.6341

Hamidreza Namazi, Vladimir V. Kulish, Jamal Hussaini, Jalal Hussaini, Ali Delaviz, Fatemeh Delaviz, Shaghayegh Habibi,  and Sara Ramezanpoor
342-350
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An hTERT/ZEB1 complex directly regulates E-cadherin to promote epithelial-to-mesenchymal transition (EMT) in colorectal cancer

An hTERT/ZEB1 complex directly regulates E-cadherin to promote epithelial-to-mesenchymal transition (EMT) in colorectal cancer

https://doi.org/10.18632/oncotarget.5968

Yong Qin, Bo Tang, Chang-Jiang Hu, Yu-Feng Xiao, Rui Xie, Xin Yong, Yu-Yun Wu, Hui Dong,  and Shi-Ming Yang
351-361
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Integrin β3 and LKB1 are independently involved in the inhibition of proliferation by lovastatin in human intrahepatic cholangiocarcinoma

Integrin β3 and LKB1 are independently involved in the inhibition of proliferation by lovastatin in human intrahepatic cholangiocarcinoma

https://doi.org/10.18632/oncotarget.6238

Sheng-Huei Yang, Hung-Yun Lin, Chun A Changou, Chun-Han Chen, Yun-Ru Liu, Jinghan Wang, Xiaoqing Jiang, Frank Luh,  and Yun Yen
362-373
Abstract  |  PDF  |  HTML  |  Order a Reprint

Salmonella overcomes tumor immune tolerance by inhibition of tumor indoleamine 2, 3-dioxygenase 1 expression

Salmonella overcomes tumor immune tolerance by inhibition of tumor indoleamine 2, 3-dioxygenase 1 expression

https://doi.org/10.18632/oncotarget.6258

Yu-Diao Kuan,  and Che-Hsin Lee
374-385
Abstract  |  PDF  |  HTML  |  Order a Reprint

MDA-9/Syntenin-Slug transcriptional complex promote epithelial-mesenchymal transition and invasion/metastasis in lung adenocarcinoma

MDA-9/Syntenin-Slug transcriptional complex promote epithelial-mesenchymal transition and invasion/metastasis in lung adenocarcinoma

https://doi.org/10.18632/oncotarget.6299

Lu-Kai Wang, Szu-Hua Pan, Yih-Leong Chang, Pei-Fang Hung, Shih-Han Kao, Wen-Lung Wang, Ching-Wen Lin, Shuenn-Chen Yang, Chen-Hsien Liang, Chen-Tu Wu, Tzu-Hung Hsiao, Tse-Ming Hong,  and Pan-Chyr Yang
386-401
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Novel histone deacetylase inhibitor MPT0G009 induces cell apoptosis and synergistic anticancer activity with tumor necrosis factor-related apoptosis-inducing ligand against human hepatocellular carcinoma

Novel histone deacetylase inhibitor MPT0G009 induces cell apoptosis and synergistic anticancer activity with tumor necrosis factor-related apoptosis-inducing ligand against human hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.6352

Mei-Chuan Chen, Hui-Hsuan Huang, Chin-Yu Lai, Yi-Jyun Lin, Jing-Ping Liou, Mei-Jung Lai, Yu-Hsuan Li, Che-Ming Teng,  and Chia-Ron Yang
402-417
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The ribosomal protein S6 in renal cell carcinoma: functional relevance and potential as biomarker

The ribosomal protein S6 in renal cell carcinoma: functional relevance and potential as biomarker

https://doi.org/10.18632/oncotarget.6225

Maximilian Knoll, Stephan Macher-Goeppinger, Jürgen Kopitz, Stefan Duensing, Sascha Pahernik, Markus Hohenfellner, Peter Schirmacher,  and Wilfried Roth
418-432
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

HSP90 inhibition blocks ERBB3 and RET phosphorylation in myxoid/round cell liposarcoma and causes massive cell death in vitro and in vivo

HSP90 inhibition blocks ERBB3 and RET phosphorylation in myxoid/round cell liposarcoma and causes massive cell death in vitro and in vivo

https://doi.org/10.18632/oncotarget.6336

Setareh Safavi, Sofia Järnum, Christoffer Vannas, Sameer Udhane, Emma Jonasson, Tajana Tesan Tomic, Pernilla Grundevik, Henrik Fagman, Magnus Hansson, Zeynep Kalender, Alexandra Jauhiainen, Soheila Dolatabadi, Eva Wessel Stratford, Ola Myklebost, Mikael Eriksson, Göran Stenman, Regine Schneider Stock, Anders Ståhlberg,  and Pierre Åman
433-445
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Interleukin-6 suppression reduces tumour self-seeding by circulating tumour cells in a human osteosarcoma nude mouse model

Interleukin-6 suppression reduces tumour self-seeding by circulating tumour cells in a human osteosarcoma nude mouse model

https://doi.org/10.18632/oncotarget.6371

Yinglong Zhang, Qiong Ma, Tao Liu, Guofeng Guan, Kailiang Zhang, Jiayan Chen, Nan Jia, Shiju Yan, Guanyin Chen, Shiluan Liu, Kuo Jiang, Yao Lu, Yanhua Wen, Haien Zhao, Yong Zhou, Qingyu Fan,  and Xiuchun Qiu
446-458
Abstract  |  PDF  |  HTML  |  Order a Reprint

Atracurium Besylate and other neuromuscular blocking agents promote astroglial differentiation and deplete glioblastoma stem cells

Atracurium Besylate and other neuromuscular blocking agents promote astroglial differentiation and deplete glioblastoma stem cells

https://doi.org/10.18632/oncotarget.6314

Raffaella Spina, Dillon M. Voss, Laura Asnaghi, Andrew Sloan,  and Eli E. Bar
459-472
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

HBx sensitizes hepatocellular carcinoma cells to lapatinib by up-regulating ErbB3

HBx sensitizes hepatocellular carcinoma cells to lapatinib by up-regulating ErbB3

https://doi.org/10.18632/oncotarget.6337

Jhen-Yu Chen, Yun-Ju Chen, Chia-Jui Yen, Wen-Shu Chen,  and Wei-Chien Huang
473-489
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Down-regulation of oxidative phosphorylation in the liver by expression of the ATPase inhibitory factor 1 induces a tumor-promoter metabolic state

Down-regulation of oxidative phosphorylation in the liver by expression of the ATPase inhibitory factor 1 induces a tumor-promoter metabolic state

https://doi.org/10.18632/oncotarget.6357

Fulvio Santacatterina, Laura Sánchez-Cenizo, Laura Formentini, Maysa A. Mobasher, Estela Casas, Carlos B. Rueda, Inmaculada Martínez-Reyes, Cristina Núñez de Arenas, Javier García-Bermúdez, Juan M. Zapata, María Sánchez-Aragó, Jorgina Satrústegui, Ángela M. Valverde,  and José M. Cuezva
490-508
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Protein 4.1N acts as a potential tumor suppressor linking PP1 to JNK-c-Jun pathway regulation in NSCLC

Protein 4.1N acts as a potential tumor suppressor linking PP1 to JNK-c-Jun pathway regulation in NSCLC

https://doi.org/10.18632/oncotarget.6312

Zi Wang, Bianyin Ma, Hui Li, Xiaojuan Xiao, Weihua Zhou, Feng Liu, Bin Zhang, Min Zhu, Qin Yang, Yayue Zeng, Yang Sun, Shuming Sun, Yanpeng Wang, Yibin Zhang, Haibo Weng, Lixiang Chen, Mao Ye, Xiuli An,  and Jing Liu
509-523
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Decreased expression of PBLD correlates with poor prognosis and functions as a tumor suppressor in human hepatocellular carcinoma

Decreased expression of PBLD correlates with poor prognosis and functions as a tumor suppressor in human hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.6358

Aimin Li, Qun Yan, Xinmei Zhao, Jietao Zhong, Haiyun Yang, Zhiqiang Feng, Yanlei Du, Yadong Wang, Zenan Wang, Hong Wang, Yongjian Zhou, Side Liu,  and Yuqiang Nie
524-537
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The miR27b-CCNG1-P53-miR-508-5p axis regulates multidrug resistance of gastric cancer

The miR27b-CCNG1-P53-miR-508-5p axis regulates multidrug resistance of gastric cancer

https://doi.org/10.18632/oncotarget.6374

Yulong Shang, Bin Feng, Lin Zhou, Gui Ren, Zhiyong Zhang, Xing Fan, Yi Sun, Guanhong Luo, Jie Liang, Kaichun Wu, Yongzhan Nie,  and Daiming Fan
538-549
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Immunohistochemical prediction of lapatinib efficacy in advanced HER2-positive breast cancer patients

Immunohistochemical prediction of lapatinib efficacy in advanced HER2-positive breast cancer patients

https://doi.org/10.18632/oncotarget.6375

Renata Duchnowska, Piotr J. Wysocki, Konstanty Korski, Bogumiła Czartoryska- Arłukowicz, Anna Niwińska, Marlena Orlikowska, Barbara Radecka, Maciej Studziński, Regina Demlova, Barbara Ziółkowska, Monika Merdalska, Łukasz Hajac, Paulina Myśliwiec, Dorota Zuziak, Sylwia Dębska-Szmich, Istvan Lang, Małgorzata Foszczyńska-Kłoda, Bożenna Karczmarek-Borowska, Anton Żawrocki, Anna Kowalczyk, Wojciech Biernat, Jacek Jassem,  and for the Central and East European Oncology Group (CEEOG)
550-564
Abstract  |  PDF  |  HTML  |  Order a Reprint

Dasatinib induces DNA damage and activates DNA repair pathways leading to senescence in non-small cell lung cancer cell lines with kinase-inactivating BRAF mutations

Dasatinib induces DNA damage and activates DNA repair pathways leading to senescence in non-small cell lung cancer cell lines with kinase-inactivating BRAF mutations

https://doi.org/10.18632/oncotarget.6376

Shaohua Peng, Banibrata Sen, Tuhina Mazumdar, Lauren A. Byers, Lixia Diao, Jing Wang, Pan Tong, Uma Giri, John V. Heymach, Humam N. Kadara,  and Faye M. Johnson
565-579
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MiR-221 promotes stemness of breast cancer cells by targeting DNMT3b

MiR-221 promotes stemness of breast cancer cells by targeting DNMT3b

https://doi.org/10.18632/oncotarget.5979

Giuseppina Roscigno, Cristina Quintavalle, Elvira Donnarumma, Ilaria Puoti, Angel Diaz-Lagares, Margherita Iaboni, Danilo Fiore, Valentina Russo, Matilde Todaro, Giulia Romano, Renato Thomas, Giuseppina Cortino, Miriam Gaggianesi, Manel Esteller, Carlo M. Croce,  and Gerolama Condorelli
580-592
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Transmembrane protein CD9 is glioblastoma biomarker, relevant for maintenance of glioblastoma stem cells

Transmembrane protein CD9 is glioblastoma biomarker, relevant for maintenance of glioblastoma stem cells

https://doi.org/10.18632/oncotarget.5477

Neža Podergajs, Helena Motaln, Uroš Rajčević, Urška Verbovšek, Marjan Koršič, Nina Obad, Heidi Espedal, Miloš Vittori, Christel Herold-Mende, Hrvoje Miletic, Rolf Bjerkvig,  and Tamara Lah Turnšek
593-609
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Inhibition of mitochondrial glutaminase activity reverses acquired erlotinib resistance in non-small cell lung cancer

Inhibition of mitochondrial glutaminase activity reverses acquired erlotinib resistance in non-small cell lung cancer

https://doi.org/10.18632/oncotarget.6311

Caifeng Xie, Jiangbo Jin, Xujie Bao, Wei-Hua Zhan, Tian-Yu Han, Mingxi Gan, Chengfu Zhang,  and Jianbin Wang
610-621
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Long non-coding RNA ZFAS1 interacts with CDK1 and is involved in p53-dependent cell cycle control and apoptosis in colorectal cancer

Long non-coding RNA ZFAS1 interacts with CDK1 and is involved in p53-dependent cell cycle control and apoptosis in colorectal cancer

https://doi.org/10.18632/oncotarget.5807

Nithyananda Thorenoor, Petra Faltejskova-Vychytilova, Sonja Hombach, Jitka Mlcochova, Markus Kretz, Marek Svoboda,  and Ondrej Slaby
622-637
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

SET antagonist enhances the chemosensitivity of non-small cell lung cancer cells by reactivating protein phosphatase 2A

SET antagonist enhances the chemosensitivity of non-small cell lung cancer cells by reactivating protein phosphatase 2A

https://doi.org/10.18632/oncotarget.6313

Man-Hsin Hung, Cheng-Yi Wang, Yen-Lin Chen, Pei-Yi Chu, Yung-Jen Hsiao, Wei-Tien Tai, Ting-Ting Chao, Hui-Chuan Yu, Chung-Wai Shiau,  and Kuen-Feng Chen
638-655
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Molecular pathway activation features linked with transition from normal skin to primary and metastatic melanomas in human

Molecular pathway activation features linked with transition from normal skin to primary and metastatic melanomas in human

https://doi.org/10.18632/oncotarget.6394

Denis Shepelin, Mikhail Korzinkin, Anna Vanyushina, Alexander Aliper, Nicolas Borisov, Raif Vasilov, Nikolay Zhukov, Dmitry Sokov, Vladimir Prassolov, Nurshat Gaifullin, Alex Zhavoronkov, Bhupinder Bhullar,  and Anton Buzdin
656-670
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A HLA-A2-restricted CTL epitope induces anti-tumor effects against human lung cancer in mouse xenograft model

A HLA-A2-restricted CTL epitope induces anti-tumor effects against human lung cancer in mouse xenograft model

https://doi.org/10.18632/oncotarget.6400

Yuh-Pyng Sher, Su-I Lin, I-Hua Chen, Hsin-Yu Liu, Chen-Yuan Lin, I-Ping Chiang, Steve Roffler, Hsin-Wei Chen,  and Shih-Jen Liu
671-683
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The TERT promoter SNP rs2853669 decreases E2F1 transcription factor binding and increases mortality and recurrence risks in liver cancer

The TERT promoter SNP rs2853669 decreases E2F1 transcription factor binding and increases mortality and recurrence risks in liver cancer

https://doi.org/10.18632/oncotarget.6331

Eunkyong Ko, Hyun-Wook Seo, Eun Sun Jung, Baek-hui Kim,  and Guhung Jung
684-699
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BAG3 elevation inhibits cell proliferation via direct interaction with G6PD in hepatocellular carcinomas

BAG3 elevation inhibits cell proliferation via direct interaction with G6PD in hepatocellular carcinomas

https://doi.org/10.18632/oncotarget.6396

De-Hui Kong, Si Li, Zhen-Xian Du, Chuan Liu, Bao-Qin Liu, Chao Li, Zhi-Hong Zong,  and Hua-Qin Wang
700-711
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Peritoneal and hematogenous metastases of ovarian cancer cells are both controlled by the p90RSK through a self-reinforcing cell autonomous mechanism

Peritoneal and hematogenous metastases of ovarian cancer cells are both controlled by the p90RSK through a self-reinforcing cell autonomous mechanism

https://doi.org/10.18632/oncotarget.6412

Erica Torchiaro, Annalisa Lorenzato, Martina Olivero, Donatella Valdembri, Paolo Armando Gagliardi, Marta Gai, Jessica Erriquez, Guido Serini,  and Maria Flavia Di Renzo
712-728
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Overexpression of HE4 (human epididymis protein 4) enhances proliferation, invasion and metastasis of ovarian cancer

Overexpression of HE4 (human epididymis protein 4) enhances proliferation, invasion and metastasis of ovarian cancer

https://doi.org/10.18632/oncotarget.6327

Liancheng Zhu, Huiyu Zhuang, Huimin Wang, Mingzi Tan, Carlton L. Schwab, Lu Deng, Jian Gao, Yingying Hao, Xiao Li, Song Gao, Juanjuan Liu,  and Bei Lin
729-744
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The BMI1 inhibitor PTC-209 is a potential compound to halt cellular growth in biliary tract cancer cells

The BMI1 inhibitor PTC-209 is a potential compound to halt cellular growth in biliary tract cancer cells

https://doi.org/10.18632/oncotarget.6378

Christian Mayr, Andrej Wagner, Magdalena Loeffelberger, Daniela Bruckner, Martin Jakab, Frieder Berr, Pietro Di Fazio, Matthias Ocker, Daniel Neureiter, Martin Pichler,  and Tobias Kiesslich
745-758
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Common variations in TERT-CLPTM1L locus are reproducibly associated with the risk of nasopharyngeal carcinoma in Chinese populations

Common variations in TERT-CLPTM1L locus are reproducibly associated with the risk of nasopharyngeal carcinoma in Chinese populations

https://doi.org/10.18632/oncotarget.6397

Yang Zhang, Xiaoai Zhang, Hongxing Zhang, Yun Zhai, Zhifu Wang, Peiyao Li, Lixia Yu, Xia Xia, Ying Zhang, Yixin Zeng, Fuchu He,  and Gangqiao Zhou
759-770
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Cardamonin reduces chemotherapy-enriched breast cancer stem-like cells in vitro and in vivo

Cardamonin reduces chemotherapy-enriched breast cancer stem-like cells in vitro and in vivo

https://doi.org/10.18632/oncotarget.5819

Deyong Jia, Yuan Tan, Huijuan Liu, Sarah Ooi, Li Li, Kathryn Wright, Steffany Bennett, Christina L. Addison,  and Lisheng Wang
771-785
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

miR-302b enhances breast cancer cell sensitivity to cisplatin by regulating E2F1 and the cellular DNA damage response

miR-302b enhances breast cancer cell sensitivity to cisplatin by regulating E2F1 and the cellular DNA damage response

https://doi.org/10.18632/oncotarget.6381

Alessandra Cataldo, Douglas G. Cheung, Andrea Balsari, Elda Tagliabue, Vincenzo Coppola, Marilena V. Iorio, Dario Palmieri,  and Carlo M. Croce
786-797
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Periostin expression in intra-tumoral stromal cells is prognostic and predictive for colorectal carcinoma via creating a cancer-supportive niche

Periostin expression in intra-tumoral stromal cells is prognostic and predictive for colorectal carcinoma via creating a cancer-supportive niche

https://doi.org/10.18632/oncotarget.5985

Xiaowen Xu, Wenjun Chang, Jie Yuan, Xue Han, Xiaojie Tan, Yibo Ding, Yanxin Luo, Hui Cai, Yan Liu, Xianhua Gao, Qizhi Liu, Yongwei Yu, Yan Du, Hao Wang, Liye Ma, Jianping Wang, Kun Chen, Yanqing Ding, Chuangang Fu,  and Guangwen Cao
798-813
Abstract  |  PDF  |  HTML  |  Order a Reprint

Cooperative therapeutic anti-tumor effect of IL-15 agonist ALT-803 and co-targeting soluble NKG2D ligand sMIC

Cooperative therapeutic anti-tumor effect of IL-15 agonist ALT-803 and co-targeting soluble NKG2D ligand sMIC

https://doi.org/10.18632/oncotarget.6416

Fahmin Basher, Emily K. Jeng, Hing Wong,  and Jennifer Wu
814-830
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Auranofin is a potent suppressor of osteosarcoma metastasis

Auranofin is a potent suppressor of osteosarcoma metastasis

https://doi.org/10.18632/oncotarget.5704

Eleni Topkas, Na Cai, Andrew Cumming, Mehlika Hazar-Rethinam, Orla Margaret Gannon, Melinda Burgess, Nicholas Andrew Saunders,  and Liliana Endo-Munoz
831-844
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Synergistic cooperation between ABT-263 and MEK1/2 inhibitor: effect on apoptosis and proliferation of acute myeloid leukemia cells

Synergistic cooperation between ABT-263 and MEK1/2 inhibitor: effect on apoptosis and proliferation of acute myeloid leukemia cells

https://doi.org/10.18632/oncotarget.6417

Kelly Airiau, Valérie Prouzet-Mauléon, Benoit Rousseau, Arnaud Pigneux, Marie Jeanneteau, Manon Giraudon, Kaoutar Allou, Pierre Dubus, Francis Belloc,  and François-Xavier Mahon
845-859
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

GDF15 promotes EMT and metastasis in colorectal cancer

GDF15 promotes EMT and metastasis in colorectal cancer

https://doi.org/10.18632/oncotarget.6205

Chen Li, Jingyu Wang, Jianlu Kong, Jinlong Tang, Yihua Wu, Enping Xu, Honghe Zhang,  and Maode Lai
860-872
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Metformin suppresses hypoxia-induced stabilization of HIF-1α through reprogramming of oxygen metabolism in hepatocellular carcinoma

Metformin suppresses hypoxia-induced stabilization of HIF-1α through reprogramming of oxygen metabolism in hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.6418

Xinke Zhou, Jitao Chen, Gao Yi, Min Deng, Hao Liu, Min Liang, Boyun Shi, Xin Fu, Yuqin Chen, Liangcai Chen, Zhimin He, Jian Wang,  and Jifang Liu
873-884
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Whole-genome duplication increases tumor cell sensitivity to MPS1 inhibition

Whole-genome duplication increases tumor cell sensitivity to MPS1 inhibition

https://doi.org/10.18632/oncotarget.6432

Mohamed Jemaà, Gwenola Manic, Gwendaline Lledo, Delphine Lissa, Christelle Reynes, Nathalie Morin, Frédéric Chibon, Antonella Sistigu, Maria Castedo, Ilio Vitale, Guido Kroemer,  and Ariane Abrieu
885-901
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Molecular heterogeneity of glioblastomas: does location matter?

Molecular heterogeneity of glioblastomas: does location matter?

https://doi.org/10.18632/oncotarget.6433

Emilie Denicolaï, Emeline Tabouret, Carole Colin, Philippe Metellus, Isabelle Nanni, Celine Boucard, Aurélie Tchoghandjian, David Meyronet, Nathalie Baeza-Kallee, Olivier Chinot,  and Dominique Figarella-Branger
902-913
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Intra-tumor AvidinOX allows efficacy of low dose systemic biotinylated Cetuximab in a model of head and neck cancer

Intra-tumor AvidinOX allows efficacy of low dose systemic biotinylated Cetuximab in a model of head and neck cancer

https://doi.org/10.18632/oncotarget.6089

Loredana Vesci, Ferdinando Maria Milazzo, Anna Maria Anastasi, Fiorella Petronzelli, Caterina Chiapparino, Valeria Carollo, Giuseppe Roscilli, Emanuele Marra, Laura Luberto, Luigi Aurisicchio, Maria Lucrezia Pacello, Luigi Giusto Spagnoli,  and Rita De Santis
914-928
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

miR-214/199a/199a* cluster levels predict poor survival in hepatocellular carcinoma through interference with cell-cycle regulators

miR-214/199a/199a* cluster levels predict poor survival in hepatocellular carcinoma through interference with cell-cycle regulators

https://doi.org/10.18632/oncotarget.6137

Peipei Wang, Song Chen, He Fang, Xiaojuan Wu, Dabiao Chen, Liang Peng, Zhiliang Gao,  and Chan Xie
929-945
Abstract  |  PDF  |  HTML  |  Order a Reprint

The HMG-CoA reductase inhibitor, simvastatin, exhibits anti-metastatic and anti-tumorigenic effects in ovarian cancer

The HMG-CoA reductase inhibitor, simvastatin, exhibits anti-metastatic and anti-tumorigenic effects in ovarian cancer

https://doi.org/10.18632/oncotarget.5834

Jessica E. Stine, Hui Guo, Xiugui Sheng, Xiaoyun Han, Monica N. Schointuch, Timothy P. Gilliam, Paola A. Gehrig, Chunxiao Zhou,  and Victoria L. Bae-Jump
946-960
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Knockdown of linc-POU3F3 suppresses the proliferation, apoptosis, and migration resistance of colorectal cancer

Knockdown of linc-POU3F3 suppresses the proliferation, apoptosis, and migration resistance of colorectal cancer

https://doi.org/10.18632/oncotarget.5830

Ti-Dong Shan, Ji-Hao Xu, Tao Yu, Jie-Yao Li, Lin-Na Zhao, Hui Ouyang, Su Luo, Xi-Ji Lu, Can-Ze Huang, Qiu-Shen Lan, Wa Zhong,  and Qi-Kui Chen
961-975
Abstract  |  PDF  |  HTML  |  Order a Reprint

In-depth characterization of breast cancer tumor-promoting cell transcriptome by RNA sequencing and microarrays

In-depth characterization of breast cancer tumor-promoting cell transcriptome by RNA sequencing and microarrays

https://doi.org/10.18632/oncotarget.5810

Maurizio Callari, Alessandro Guffanti, Giulia Soldà, Giuseppe Merlino, Emanuela Fina, Elena Brini, Anna Moles, Vera Cappelletti,  and Maria Grazia Daidone
976-994
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Diet-derived 25-hydroxyvitamin D3 activates vitamin D receptor target gene expression and suppresses EGFR mutant non-small cell lung cancer growth in vitro and in vivo

Diet-derived 25-hydroxyvitamin D3 activates vitamin D receptor target gene expression and suppresses EGFR mutant non-small cell lung cancer growth in vitro and in vivo

https://doi.org/10.18632/oncotarget.6493

Alissa R. Verone-Boyle, Suzanne Shoemaker, Kristopher Attwood, Carl D. Morrison, Andrew J. Makowski, Sebastiano Battaglia,  and Pamela A. Hershberger
995-1013
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Clinical Research Papers

Predictive value of pretreatment lymphocyte count in stage II colorectal cancer and in high-risk patients treated with adjuvant chemotherapy

Predictive value of pretreatment lymphocyte count in stage II colorectal cancer and in high-risk patients treated with adjuvant chemotherapy

https://doi.org/10.18632/oncotarget.5835

Lei Liang, Ji Zhu, Huixun Jia, Liyong Huang, Dawei Li, Qingguo Li,  and Xinxiang Li
1014-1028
Abstract  |  PDF  |  HTML  |  Order a Reprint

Clinical significance of accurate identification of lymph node status in distant metastatic gastric cancer

Clinical significance of accurate identification of lymph node status in distant metastatic gastric cancer

https://doi.org/10.18632/oncotarget.6009

Rui Zhou, Zhenzhen Wu, Jingwen Zhang, Hongqiang Wang, Yuqi Su, Na Huang, Min Shi, Jianping Bin, Yulin Liao,  and Wangjun Liao
1029-1041
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Early cardiac toxicity following adjuvant radiotherapy of left-sided breast cancer with or without concurrent trastuzumab

Early cardiac toxicity following adjuvant radiotherapy of left-sided breast cancer with or without concurrent trastuzumab

https://doi.org/10.18632/oncotarget.6053

Lu Cao, Gang Cai, Cai Chang, Zhao-Zhi Yang, Yan Feng, Xiao-Li Yu, Jin-Li Ma, Jiong Wu, Xiao-Mao Guo,  and Jia-Yi Chen
1042-1054
Abstract  |  PDF  |  HTML  |  Order a Reprint

Social inequalities and cancer: can the European deprivation index predict patients’ difficulties in health care access? a pilot study

Social inequalities and cancer: can the European deprivation index predict patients’ difficulties in health care access? a pilot study

https://doi.org/10.18632/oncotarget.6274

Guillaume Moriceau, Aurélie Bourmaud, Fabien Tinquaut, Mathieu Oriol, Jean-Philippe Jacquin, Pierre Fournel, Nicolas Magné,  and Franck Chauvin
1055-1065
Abstract  |  PDF  |  HTML  |  Order a Reprint

Rearranged EML4-ALK fusion transcripts sequester in circulating blood platelets and enable blood-based crizotinib response monitoring in non-small-cell lung cancer

Rearranged EML4-ALK fusion transcripts sequester in circulating blood platelets and enable blood-based crizotinib response monitoring in non-small-cell lung cancer

https://doi.org/10.18632/oncotarget.6279

R. Jonas A. Nilsson, Niki Karachaliou, Jordi Berenguer, Ana Gimenez-Capitan, Pepijn Schellen, Cristina Teixido, Jihane Tannous, Justine L. Kuiper, Esther Drees, Magda Grabowska, Marte van Keulen, Danielle A. M. Heideman, Erik Thunnissen, Anne-Marie C. Dingemans, Santiago Viteri, Bakhos A. Tannous, Ana Drozdowskyj, Rafael Rosell, Egbert F. Smit,  and Thomas Wurdinger
1066-1075
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint


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