Oncotarget

Vol 6, No 42

December 29, 2015

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ASXL1 mutation correction by CRISPR/Cas9 restores gene function in leukemia cells and increases survival in mouse xenografts. See Valletta et al.

Table of Contents

Editorial

Immunosuppression by hemorrhagic fever-causing viruses

Immunosuppression by hemorrhagic fever-causing viruses

https://doi.org/10.18632/oncotarget.6509

Bjoern Meyer,  and Hinh Ly
44057-44058
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KIM-1/TIM-1 in proximal tubular cell immune response

KIM-1/TIM-1 in proximal tubular cell immune response

https://doi.org/10.18632/oncotarget.6623

Craig R. Brooks,  and Joseph V. Bonventre
44059-44060
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Priority Research Papers

ASXL1 mutation correction by CRISPR/Cas9 restores gene function in leukemia cells and increases survival in mouse xenografts

ASXL1 mutation correction by CRISPR/Cas9 restores gene function in leukemia cells and increases survival in mouse xenografts

https://doi.org/10.18632/oncotarget.6392

Simona Valletta, Hamid Dolatshad, Matthias Bartenstein, Bon Ham Yip, Erica Bello, Shanisha Gordon, Yiting Yu, Jacqueline Shaw, Swagata Roy, Laura Scifo, Anna Schuh, Andrea Pellagatti, Tudor A. Fulga, Amit Verma,  and Jacqueline Boultwood
44061-44071
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SRC family kinase FYN promotes the neuroendocrine phenotype and visceral metastasis in advanced prostate cancer

SRC family kinase FYN promotes the neuroendocrine phenotype and visceral metastasis in advanced prostate cancer

https://doi.org/10.18632/oncotarget.6398

Murali Gururajan, Karen A. Cavassani, Margarit Sievert, Peng Duan, Jake Lichterman, Jen-Ming Huang, Bethany Smith, Sungyong You, Srinivas Nandana, Gina Chia-Yi Chu, Sheldon Mink, Sajni Josson, Chunyan Liu, Matteo Morello, Lawrence W. M. Jones, Jayoung Kim, Michael R. Freeman, Neil Bhowmick, Haiyen E. Zhau, Leland W.K. Chung,  and Edwin M. Posadas
44072-44083
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Mitochondrial retrograde signaling inhibits the survival during prolong S/G2 arrest in Saccharomyces cerevisiae

Mitochondrial retrograde signaling inhibits the survival during prolong S/G2 arrest in Saccharomyces cerevisiae

https://doi.org/10.18632/oncotarget.6406

Anna N. Zyrina, Maksim I. Sorokin, Sviatoslav S. Sokolov, Dmitry A. Knorre,  and Fedor F. Severin
44084-44094
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MKP1 mediates chemosensitizer effects of E1a in response to cisplatin in non-small cell lung carcinoma cells

MKP1 mediates chemosensitizer effects of E1a in response to cisplatin in non-small cell lung carcinoma cells

https://doi.org/10.18632/oncotarget.6574

Francisco J. Cimas, Juan L. Callejas-Valera, Raquel Pascual-Serra, Jesus García-Cano, Elena Garcia-Gil, Miguel De la Cruz-Morcillo, Marta Ortega-Muelas, Leticia Serrano-Oviedo, J. Silvio Gutkind,  and Ricardo Sánchez-Prieto
44095-44107
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Research Papers: Pathology

Ketamine-mediated afferent-specific presynaptic transmission blocks in low-threshold and sex-specific subpopulation of myelinated Ah-type baroreceptor neurons of rats

Ketamine-mediated afferent-specific presynaptic transmission blocks in low-threshold and sex-specific subpopulation of myelinated Ah-type baroreceptor neurons of rats

https://doi.org/10.18632/oncotarget.6586

Lu-Qi Wang, Sheng-Zhi Liu, Xin Wen, Di Wu, Lei Yin, Yao Fan, Ye Wang, Wei-Ran Chen, Pei Chen, Yang Liu, Xiao-Long Lu, Hong-Li Sun, Weinian Shou, Guo-Fen Qiao,  and Bai-Yan Li
44108-44122
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Research Papers: Immunology

Transpresentation of interleukin‑15 by IL-15/IL-15Rα mRNA-engineered human dendritic cells boosts antitumoral natural killer cell activity

Transpresentation of interleukin‑15 by IL-15/IL-15Rα mRNA-engineered human dendritic cells boosts antitumoral natural killer cell activity

https://doi.org/10.18632/oncotarget.6536

Johan Van den Bergh, Yannick Willemen, Eva Lion, Heleen Van Acker, Hans De Reu, Sébastien Anguille, Herman Goossens, Zwi Berneman, Viggo Van Tendeloo,  and Evelien Smits
44123-44133
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Enhancement of adoptive T cell transfer with single low dose pretreatment of doxorubicin or paclitaxel in mice

Enhancement of adoptive T cell transfer with single low dose pretreatment of doxorubicin or paclitaxel in mice

https://doi.org/10.18632/oncotarget.6628

Fei-Ting Hsu, Tzu-Chun Chen, Hui-Yen Chuang, Ya-Fang Chang,  and Jeng-Jong Hwang
44134-44150
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Cytokine secretion and NK cell activity in human ADAM17 deficiency

Cytokine secretion and NK cell activity in human ADAM17 deficiency

https://doi.org/10.18632/oncotarget.6629

Pinchas Tsukerman, Eli M. Eisenstein, Maor Chavkin, Dominik Schmiedel, Eitan Wong, Marion Werner, Barak Yaacov, Diana Averbuch, Vered Molho-Pessach, Polina Stepensky, Noa Kaynan, Yotam Bar-On, Einat Seidel, Rachel Yamin, Irit Sagi, Orly Elpeleg,  and Ofer Mandelboim
44151-44160
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Research Papers: Autophagy and Cell Death

Streptococcus pneumoniae induces pyroptosis through the regulation of autophagy in murine microglia

Streptococcus pneumoniae induces pyroptosis through the regulation of autophagy in murine microglia

https://doi.org/10.18632/oncotarget.6592

Ji-Yun Kim, James C. Paton, David E. Briles, Dong-Kwon Rhee,  and Suhkneung Pyo
44161-44178
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Reviews

Therapeutic potential of CAR-T cell-derived exosomes: a cell-free modality for targeted cancer therapy

Therapeutic potential of CAR-T cell-derived exosomes: a cell-free modality for targeted cancer therapy

https://doi.org/10.18632/oncotarget.6175

Xiang-Jun Tang, Xu-Yong Sun, Kuan-Ming Huang, Li Zhang, Zhuo-Shun Yang, Dan-Dan Zou, Bin Wang, Garth L. Warnock, Long-Jun Dai,  and Jie Luo
44179-44190
Abstract  |  PDF  |  HTML  |  Order a Reprint

Cancer stem cell targeted therapy: progress amid controversies

Cancer stem cell targeted therapy: progress amid controversies

https://doi.org/10.18632/oncotarget.6176

Tao Wang, Sarah Shigdar, Michael P. Gantier, Yingchun Hou, Li Wang, Yong Li, Hadi Al Shamaileh, Wang Yin, Shu-Feng Zhou, Xinhan Zhao,  and Wei Duan
44191-44206
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Research Papers

Growth-arrest-specific 7C protein inhibits tumor metastasis via the N-WASP/FAK/F-actin and hnRNP U/β-TrCP/β-catenin pathways in lung cancer

Growth-arrest-specific 7C protein inhibits tumor metastasis via the N-WASP/FAK/F-actin and hnRNP U/β-TrCP/β-catenin pathways in lung cancer

https://doi.org/10.18632/oncotarget.6229

Ruo-Chia Tseng, Jer-Wei Chang, Jiou-Shan Mao, Charng-Dar Tsai, Pei-Chen Wu, Cuei-Jyuan Lin, Yi-Lin Lu, Sheng-You Liao, Hung-Chi Cheng, Han-Shui Hsu,  and Yi-Ching Wang
44207-44221
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Foxo3a-mediated overexpression of microRNA-622 suppresses tumor metastasis by repressing hypoxia-inducible factor-1α in ERK-responsive lung cancer

Foxo3a-mediated overexpression of microRNA-622 suppresses tumor metastasis by repressing hypoxia-inducible factor-1α in ERK-responsive lung cancer

https://doi.org/10.18632/oncotarget.5826

Chun-Wen Cheng, Po-Ming Chen, Yi-Hsien Hsieh, Chung-Chih Weng, Chia-Wei Chang, Chung-Chin Yao, Pei-Ei Wu,  and Chen-Yang Shen
44222-44238
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Phenotype and function of CXCR5+CD45RA−CD4+ T cells were altered in HBV-related hepatocellular carcinoma and elevated serum CXCL13 predicted better prognosis

Phenotype and function of CXCR5+CD45RA−CD4+ T cells were altered in HBV-related hepatocellular carcinoma and elevated serum CXCL13 predicted better prognosis

https://doi.org/10.18632/oncotarget.6235

Zhaojun Duan, Jian Gao, Ling Zhang, Hua Liang, Xiangbo Huang, Qiang Xu, Yu Zhang, Tao Shen,  and Fengmin Lu
44239-44253
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

FN14 and GRP94 expression are prognostic/predictive biomarkers of brain metastasis outcome that open up new therapeutic strategies

FN14 and GRP94 expression are prognostic/predictive biomarkers of brain metastasis outcome that open up new therapeutic strategies

https://doi.org/10.18632/oncotarget.5471

Antonio Martínez-Aranda, Vanessa Hernández, Emre Guney, Laia Muixí, Ruben Foj, Núria Baixeras, Daniel Cuadras, Víctor Moreno, Ander Urruticoechea, Miguel Gil, Baldo Oliva, Ferran Moreno, Eva González-Suarez, Noemí Vidal, Xavier Andreu, Miquel A. Seguí, Rosa Ballester, Eva Castella,  and Angels Sierra
44254-44273
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

244-MPT overcomes gefitinib resistance in non-small cell lung cancer cells

244-MPT overcomes gefitinib resistance in non-small cell lung cancer cells

https://doi.org/10.18632/oncotarget.6236

Yi Zhang, Ke Yao, Chengcheng Shi, Yanan Jiang, Kangdong Liu, Song Zhao, Hanyong Chen, Kanamata Reddy, Chengjuan Zhang, Xiaoyu Chang, Joohyun Ryu, Ann M. Bode, Ziming Dong,  and Zigang Dong
44274-44288
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The orally active and bioavailable ATR kinase inhibitor AZD6738 potentiates the anti-tumor effects of cisplatin to resolve ATM-deficient non-small cell lung cancer in vivo

The orally active and bioavailable ATR kinase inhibitor AZD6738 potentiates the anti-tumor effects of cisplatin to resolve ATM-deficient non-small cell lung cancer in vivo

https://doi.org/10.18632/oncotarget.6247

Frank P. Vendetti, Alan Lau, Sandra Schamus, Thomas P. Conrads, Mark J. O’Connor,  and Christopher J. Bakkenist
44289-44305
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Radioresistant human lung adenocarcinoma cells that survived multiple fractions of ionizing radiation are sensitive to HSP90 inhibition

Radioresistant human lung adenocarcinoma cells that survived multiple fractions of ionizing radiation are sensitive to HSP90 inhibition

https://doi.org/10.18632/oncotarget.6248

Roberto Gomez-Casal, Michael W. Epperly, Hong Wang, David A. Proia, Joel S. Greenberger,  and Vera Levina
44306-44322
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Increased expression of CX43 on stromal cells promotes leukemia apoptosis

Increased expression of CX43 on stromal cells promotes leukemia apoptosis

https://doi.org/10.18632/oncotarget.6249

Shijie Yang, Qin Wen, Yao Liu, Cheng Zhang, Maihong Wang, Guo Chen, Yi Gong, Jiangjian Zhong, Xuelian Chen, Andres Stucky, Jiang F. Zhong,  and Xi Zhang
44323-44331
Abstract  |  PDF  |  HTML  |  Order a Reprint

Implication of epithelial-mesenchymal transition in IGF1R-induced resistance to EGFR-TKIs in advanced non-small cell lung cancer

Implication of epithelial-mesenchymal transition in IGF1R-induced resistance to EGFR-TKIs in advanced non-small cell lung cancer

https://doi.org/10.18632/oncotarget.6293

Juan Zhou, Jinjing Wang, Yunyun Zeng, Xi Zhang, Qiaoting Hu, Jihua Zheng, Bei Chen, Bo Xie,  and Wei-Min Zhang
44332-44345
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Infiltrating T cells promote renal cell carcinoma (RCC) progression via altering the estrogen receptor β-DAB2IP signals

Infiltrating T cells promote renal cell carcinoma (RCC) progression via altering the estrogen receptor β-DAB2IP signals

https://doi.org/10.18632/oncotarget.5884

Chiuan-Ren Yeh, Zheng-Yu Ou, Guang-Qian Xiao, Elizabeth Guancial,  and Shuyuan Yeh
44346-44359
Abstract  |  PDF  |  HTML  |  Order a Reprint

RNase L is a negative regulator of cell migration

RNase L is a negative regulator of cell migration

https://doi.org/10.18632/oncotarget.6246

Shuvojit Banerjee, Geqiang Li, Yize Li, Christina Gaughan, Danika Baskar, Yvonne Parker, Daniel J. Lindner, Susan R. Weiss,  and Robert H. Silverman
44360-44372
Abstract  |  PDF  |  HTML  |  Order a Reprint

JAM3 methylation status as a biomarker for diagnosis of preneoplastic and neoplastic lesions of the cervix

JAM3 methylation status as a biomarker for diagnosis of preneoplastic and neoplastic lesions of the cervix

https://doi.org/10.18632/oncotarget.6250

Aijun Yin, Qing Zhang, Xiangnan Kong, Lin Jia, Ziyan Yang, Lihua Meng, Li Li, Xiao Wang, Yunbo Qiao, Nan Lu, Qifeng Yang, Keng Shen,  and Beihua Kong
44373-44387
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Estrogen and estrogen receptor alpha promotes malignancy and osteoblastic tumorigenesis in prostate cancer

Estrogen and estrogen receptor alpha promotes malignancy and osteoblastic tumorigenesis in prostate cancer

https://doi.org/10.18632/oncotarget.6317

Sweta Mishra, Qin Tai, Xiang Gu, James Schmitz, Ashley Poullard, Roberto J. Fajardo, Devalingam Mahalingam, Xiaodong Chen, Xueqiong Zhu,  and Lu-Zhe Sun
44388-44402
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Metabolic reprogramming: a new relevant pathway in adult adrenocortical tumors

Metabolic reprogramming: a new relevant pathway in adult adrenocortical tumors

https://doi.org/10.18632/oncotarget.5623

Céline Pinheiro, Sara Granja, Adhemar Longatto-Filho, André M. Faria, Maria C. B. V. Fragoso, Silvana M. Lovisolo, Antonio M. Lerário, Madson Q. Almeida, Fátima Baltazar,  and Mariateresa C. N. Zerbini
44403-44421
Abstract  |  PDF  |  HTML  |  Order a Reprint

Epigenetic silencing of tumor suppressor miR-3151 contributes to Chinese chronic lymphocytic leukemia by constitutive activation of MADD/ERK and PIK3R2/AKT signaling pathways

Epigenetic silencing of tumor suppressor miR-3151 contributes to Chinese chronic lymphocytic leukemia by constitutive activation of MADD/ERK and PIK3R2/AKT signaling pathways

https://doi.org/10.18632/oncotarget.6251

Lu Qian Wang, Kwan Yeung Wong, Anders Rosèn,  and Chor Sang Chim
44422-44436
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Anti-cancer effect of bee venom on colon cancer cell growth by activation of death receptors and inhibition of nuclear factor kappa B

Anti-cancer effect of bee venom on colon cancer cell growth by activation of death receptors and inhibition of nuclear factor kappa B

https://doi.org/10.18632/oncotarget.6295

Jie Zheng, Hye Lim Lee, Young Wan Ham, Ho Sueb Song, Min Jong Song,  and Jin Tae Hong
44437-44451
Abstract  |  PDF  |  HTML  |  Order a Reprint

Knock out CD44 in reprogrammed liver cancer cell C3A increases CSCs stemness and promotes differentiation

Knock out CD44 in reprogrammed liver cancer cell C3A increases CSCs stemness and promotes differentiation

https://doi.org/10.18632/oncotarget.6090

Shuo Han, Jinhai Guo, Yinan Liu, Zhi Zhang, Qihua He, Peng Li, Mingzhi Zhang, Haojie Sun, Ruizhi Li, Yang Li, Wotan Zeng, Jinwen Liu, Lejian Lian, Yi Gao,  and Li Shen
44452-44465
Abstract  |  PDF  |  HTML  |  Order a Reprint

Upregulation of miR-181c contributes to chemoresistance in pancreatic cancer by inactivating the Hippo signaling pathway

Upregulation of miR-181c contributes to chemoresistance in pancreatic cancer by inactivating the Hippo signaling pathway

https://doi.org/10.18632/oncotarget.6298

Meiyuan Chen, Min Wang, Simiao Xu, Xingjun Guo,  and Jianxin Jiang
44466-44479
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The Janus-faced roles of Krüppel-like factor 4 in oral squamous cell carcinoma cells

The Janus-faced roles of Krüppel-like factor 4 in oral squamous cell carcinoma cells

https://doi.org/10.18632/oncotarget.6256

Wenwen Li, Man Liu, Ying Su, Xinying Zhou, Yao Liu,  and Xinyan Zhang
44480-44494
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Aberrantly upregulated TRAP1 is required for tumorigenesis of breast cancer

Aberrantly upregulated TRAP1 is required for tumorigenesis of breast cancer

https://doi.org/10.18632/oncotarget.6252

Bo Zhang, Jing Wang, Zhen Huang, Peng Wei, Ying Liu, Junfeng Hao, Lijing Zhao, Fenglin Zhang, Yaping Tu,  and Taotao Wei
44495-44508
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Single agent BMS-911543 Jak2 inhibitor has distinct inhibitory effects on STAT5 signaling in genetically engineered mice with pancreatic cancer

Single agent BMS-911543 Jak2 inhibitor has distinct inhibitory effects on STAT5 signaling in genetically engineered mice with pancreatic cancer

https://doi.org/10.18632/oncotarget.6332

Thomas A. Mace, Reena Shakya, Omar Elnaggar, Kristin Wilson, Hannah M. Komar, Jennifer Yang, Jason R. Pitarresi, Gregory S. Young, Michael C. Ostrowski, Thomas Ludwig, Tanios Bekaii-Saab, Mark Bloomston,  and Gregory B. Lesinski
44509-44522
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Ell3 stabilizes p53 following CDDP treatment via its effects on ubiquitin-dependent and -independent proteasomal degradation pathways in breast cancer cells

Ell3 stabilizes p53 following CDDP treatment via its effects on ubiquitin-dependent and -independent proteasomal degradation pathways in breast cancer cells

https://doi.org/10.18632/oncotarget.5972

Hee-Jin Ahn, Kwang-Soo Kim, Kyung-Won Shin, Kee-Hwan Lim, Jin-Ock Kim, Je-Yong Lee, Jiewan Kim, Ji-Hoon Park, Kyung-Min Yang, Kwang-Hyun Baek, Jeong-Jae Ko,  and Kyung-Soon Park
44523-44537
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Deregulation of the miR-222-ABCG2 regulatory module in tongue squamous cell carcinoma contributes to chemoresistance and enhanced migratory/invasive potential

Deregulation of the miR-222-ABCG2 regulatory module in tongue squamous cell carcinoma contributes to chemoresistance and enhanced migratory/invasive potential

https://doi.org/10.18632/oncotarget.6253

Luodan Zhao, Yuexin Ren, Haikuo Tang, Wei Wang, Qianting He, Jingjing Sun, Xiaofeng Zhou,  and Anxun Wang
44538-44550
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Connective tissue growth factor as a novel therapeutic target in high grade serous ovarian cancer

Connective tissue growth factor as a novel therapeutic target in high grade serous ovarian cancer

https://doi.org/10.18632/oncotarget.6082

Kim Moran-Jones, Brian S. Gloss, Rajmohan Murali, David K. Chang, Emily K. Colvin, Marc D. Jones, Samuel Yuen, Viive M. Howell, Laura M. Brown, Carol W. Wong, Suzanne M. Spong, Christopher J. Scarlett, Neville F. Hacker, Sue Ghosh, Samuel C. Mok, Michael J. Birrer,  and Goli Samimi
44551-44562
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Formononetin, a novel FGFR2 inhibitor, potently inhibits angiogenesis and tumor growth in preclinical models

Formononetin, a novel FGFR2 inhibitor, potently inhibits angiogenesis and tumor growth in preclinical models

https://doi.org/10.18632/oncotarget.6310

Xiao Yu Wu, Hao Xu, Zhen Feng Wu, Che Chen, Jia Yun Liu, Guan Nan Wu, Xue Quan Yao, Fu Kun Liu, Gang Li,  and Liang Shen
44563-44578
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Suppression of tumor angiogenesis by metformin treatment via a mechanism linked to targeting of HER2/HIF-1α/VEGF secretion axis

Suppression of tumor angiogenesis by metformin treatment via a mechanism linked to targeting of HER2/HIF-1α/VEGF secretion axis

https://doi.org/10.18632/oncotarget.6373

Jichang Wang, Guangyue Li, Yaochun Wang, Shouching Tang, Xin Sun, Xuefei Feng, Yan Li, Gang Bao, Pingping Li, Xiaona Mao, Maode Wang,  and Peijun Liu
44579-44592
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Tamoxifen therapy benefit predictive signature coupled with prognostic signature of post-operative recurrent risk for early stage ER+ breast cancer

Tamoxifen therapy benefit predictive signature coupled with prognostic signature of post-operative recurrent risk for early stage ER+ breast cancer

https://doi.org/10.18632/oncotarget.6260

Hao Cai, Xiangyu Li, Jing Li, Lu Ao, Haidan Yan, Mengsha Tong, Qingzhou Guan, Mengyao Li,  and Zheng Guo
44593-44608
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Tumor invasion and metastasis regulated by microRNA-184 and microRNA-574-5p in small-cell lung cancer

Tumor invasion and metastasis regulated by microRNA-184 and microRNA-574-5p in small-cell lung cancer

https://doi.org/10.18632/oncotarget.6338

Rui Zhou, Xiaoshu Zhou, Zhongyuan Yin, Jing Guo, Ting Hu, Shun Jiang, Li Liu, Xiaorong Dong, Sheng Zhang,  and Gang Wu
44609-44622
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

EpCAM based capture detects and recovers circulating tumor cells from all subtypes of breast cancer except claudin-low

EpCAM based capture detects and recovers circulating tumor cells from all subtypes of breast cancer except claudin-low

https://doi.org/10.18632/oncotarget.5977

Alexander Ring, Neal Mineyev, Weizhu Zhu, Emily Park, Chip Lomas, Vasu Punj, Min Yu, Dany Barrak, Victoria Forte, Tania Porras, Debu Tripathy,  and Julie E. Lang
44623-44634
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

PPARα induces cell apoptosis by destructing Bcl2

PPARα induces cell apoptosis by destructing Bcl2

https://doi.org/10.18632/oncotarget.5988

Jiaming Gao, Qian Liu, Ying Xu, Xin Gong, Runyun Zhang, Chenglin Zhou, Zhaoliang Su, Jianhua Jin, Haifeng Shi, Juanjuan Shi,  and Yongzhong Hou
44635-44642
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Effect of ceritinib (LDK378) on enhancement of chemotherapeutic agents in ABCB1 and ABCG2 overexpressing cells in vitro and in vivo

Effect of ceritinib (LDK378) on enhancement of chemotherapeutic agents in ABCB1 and ABCG2 overexpressing cells in vitro and in vivo

https://doi.org/10.18632/oncotarget.5989

Jing Hu, Xu Zhang, Fang Wang, Xiaokun Wang, Ke Yang, Meng Xu, Kenneth K.W. To, Qingshan Li,  and Liwu Fu
44643-44659
Abstract  |  PDF  |  HTML  |  Order a Reprint

Mutant p53 induces EZH2 expression and promotes epithelial–mesenchymal transition by disrupting p68-Drosha complex assembly and attenuating miR-26a processing

Mutant p53 induces EZH2 expression and promotes epithelial–mesenchymal transition by disrupting p68-Drosha complex assembly and attenuating miR-26a processing

https://doi.org/10.18632/oncotarget.6350

Fei-Zhou Jiang, Yin-Yan He, Hui-Hui Wang, Hui-Lin Zhang, Jian Zhang, Xiao-Fang Yan, Xiao-Jun Wang, Qi Che, Jie-Qi Ke, Zheng Chen, Huan Tong, Yong-Li Zhang, Fang-Yuan Wang, Yi-Ran Li,  and Xiao-Ping Wan
44660-44674
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Src and STAT3 inhibitors synergize to promote tumor inhibition in renal cell carcinoma

Src and STAT3 inhibitors synergize to promote tumor inhibition in renal cell carcinoma

https://doi.org/10.18632/oncotarget.5971

Hui-Wen Lue, Brook Cole, Soumya A. M. Rao, Jennifer Podalak, Ahna Van Gaest, Carly King, Christopher A. Eide, Beth Wilmot, Changhui Xue, Paul T. Spellman, Laura M. Heiser, Jeffrey W. Tyner,  and George V. Thomas
44675-44687
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Stimulation of dendritic cells by DAMPs in ALA-PDT treated SCC tumor cells

Stimulation of dendritic cells by DAMPs in ALA-PDT treated SCC tumor cells

https://doi.org/10.18632/oncotarget.5975

Xiaojie Wang, Jie Ji, Haiyan Zhang, Zhixia Fan, Linglin Zhang, Lei Shi, Feifan Zhou, Wei R. Chen, Hongwei Wang,  and Xiuli Wang
44688-44702
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Loss of function mutations in PTPN6 promote STAT3 deregulation via JAK3 kinase in diffuse large B-cell lymphoma

Loss of function mutations in PTPN6 promote STAT3 deregulation via JAK3 kinase in diffuse large B-cell lymphoma

https://doi.org/10.18632/oncotarget.6300

Christos Demosthenous, Jing Jing Han, Guangzhen Hu, Mary Stenson,  and Mamta Gupta
44703-44713
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A network-based method to evaluate quality of reproducibility of differential expression in cancer genomics studies

A network-based method to evaluate quality of reproducibility of differential expression in cancer genomics studies

https://doi.org/10.18632/oncotarget.5987

Robin Li, Xiao Lin, Haijiang Geng, Zhihui Li, Jiabing Li, Tao Lu,  and Fangrong Yan
44714-44727
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Expression of androgen receptor splice variants in clinical breast cancers

Expression of androgen receptor splice variants in clinical breast cancers

https://doi.org/10.18632/oncotarget.6296

Theresa E. Hickey, Connie M. Irvine, Heidi Dvinge, Gerard A. Tarulli, Adrienne R. Hanson, Natalie K. Ryan, Marie A. Pickering, Stephen N. Birrell, Dong Gui Hu, Peter I. Mackenzie, Roslin Russell, Carlos Caldas, Ganesh V. Raj, Scott M. Dehm, Stephen R. Plymate, Robert K. Bradley, Wayne D. Tilley,  and Luke A. Selth
44728-44744
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Single-Molecule Localization Microscopy allows for the analysis of cancer metastasis-specific miRNA distribution on the nanoscale

Single-Molecule Localization Microscopy allows for the analysis of cancer metastasis-specific miRNA distribution on the nanoscale

https://doi.org/10.18632/oncotarget.6297

Olga Oleksiuk, Mohammed Abba, Kerem Can Tezcan, Wladimir Schaufler, Felix Bestvater, Nitin Patil, Udo Birk, Mathias Hafner, Peter Altevogt, Christoph Cremer,  and Heike Allgayer
44745-44757
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Radiation and SN38 treatments modulate the expression of microRNAs, cytokines and chemokines in colon cancer cells in a p53-directed manner

Radiation and SN38 treatments modulate the expression of microRNAs, cytokines and chemokines in colon cancer cells in a p53-directed manner

https://doi.org/10.18632/oncotarget.5815

Surajit Pathak, Wen-Jian Meng, Suman Kumar Nandy, Jie Ping, Atil Bisgin, Linda Helmfors, Patrik Waldmann,  and Xiao-Feng Sun
44758-44780
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A comparison of isolated circulating tumor cells and tissue biopsies using whole-genome sequencing in prostate cancer

A comparison of isolated circulating tumor cells and tissue biopsies using whole-genome sequencing in prostate cancer

https://doi.org/10.18632/oncotarget.6330

Runze Jiang, Yi-Tsung Lu, Hao Ho, Bo Li, Jie-Fu Chen, Millicent Lin, Fuqiang Li, Kui Wu, Hanjie Wu, Jake Lichterman, Haolei Wan, Chia-Lun Lu, William OuYang, Ming Ni, Linlin Wang, Guibo Li, Tom Lee, Xiuqing Zhang, Jonathan Yang, Matthew Rettig, Leland W.K. Chung, Huanming Yang, Ker-Chau Li, Yong Hou, Hsian-Rong Tseng, Shuang Hou, Xun Xu, Jun Wang,  and Edwin M. Posadas
44781-44793
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Expression profiling reveals transcriptional regulation by Fbxw7/mTOR pathway in radiation-induced mouse thymic lymphomas

Expression profiling reveals transcriptional regulation by Fbxw7/mTOR pathway in radiation-induced mouse thymic lymphomas

https://doi.org/10.18632/oncotarget.6328

Antoine M. Snijders, Yueyong Liu, Li Su, Yurong Huang,  and Jian-Hua Mao
44794-44805
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Lymphadenectomy promotes tumor growth and cancer cell dissemination in the spontaneous RET mouse model of human uveal melanoma

Lymphadenectomy promotes tumor growth and cancer cell dissemination in the spontaneous RET mouse model of human uveal melanoma

https://doi.org/10.18632/oncotarget.6326

Yeo Kim Pin, Karen Khoo, Muly Tham, Tan Karwai, Thiam Chung Hwee, Anne-Laure Puaux, Meow Ling Cindy Phua, Masashi Kato, Veronique Angeli,  and Jean-Pierre Abastado
44806-44818
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Tumor suppressive effect of PARP1 and FOXO3A in gastric cancers and its clinical implications

Tumor suppressive effect of PARP1 and FOXO3A in gastric cancers and its clinical implications

https://doi.org/10.18632/oncotarget.6264

See-Hyoung Park, Kyu Yun Jang, Min Jae Kim, Sarah Yoon, Yuna Jo, So Mee Kwon, Kyoung Min Kim, Keun Sang Kwon, Chan Young Kim,  and Hyun Goo Woo
44819-44831
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Bone marrow stroma-induced resistance of chronic lymphocytic leukemia cells to arsenic trioxide involves Mcl-1 upregulation and is overcome by inhibiting the PI3Kδ or PKCβ signaling pathways

Bone marrow stroma-induced resistance of chronic lymphocytic leukemia cells to arsenic trioxide involves Mcl-1 upregulation and is overcome by inhibiting the PI3Kδ or PKCβ signaling pathways

https://doi.org/10.18632/oncotarget.6265

Irene Amigo-Jiménez, Elvira Bailón, Noemí Aguilera-Montilla, María José Terol, José A. García-Marco,  and Angeles García-Pardo
44832-44848
Abstract  |  PDF  |  HTML  |  Order a Reprint

ACSL4 promotes prostate cancer growth, invasion and hormonal resistance

ACSL4 promotes prostate cancer growth, invasion and hormonal resistance

https://doi.org/10.18632/oncotarget.6438

Xinyu Wu, Fangming Deng, Yirong Li, Garrett Daniels, Xinxin Du, Qinghu Ren, Jinhua Wang, Ling Hang Wang, Yang Yang, Valerio Zhang, David Zhang, Fei Ye, Jonathan Melamed, Marie E. Monaco,  and Peng Lee
44849-44863
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Differentiation between genetic mutations of breast cancer by breath volatolomics

Differentiation between genetic mutations of breast cancer by breath volatolomics

https://doi.org/10.18632/oncotarget.6269

Orna Barash, Wei Zhang, Jeffrey M. Halpern, Qing-Ling Hua, Yue-Yin Pan, Haneen Kayal, Kayan Khoury, Hu Liu, Michael P.A. Davies,  and Hossam Haick
44864-44876
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Genomic responses to hepatitis B virus (HBV) infection in primary human hepatocytes

Genomic responses to hepatitis B virus (HBV) infection in primary human hepatocytes

https://doi.org/10.18632/oncotarget.6270

Pierre-Benoit Ancey, Barbara Testoni, Marion Gruffaz, Marie-Pierre Cros, Geoffroy Durand, Florence Le Calvez-Kelm, David Durantel, Zdenko Herceg,  and Hector Hernandez-Vargas
44877-44891
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Sensitivity of human pleural mesothelioma to oncolytic measles virus depends on defects of the type I interferon response

Sensitivity of human pleural mesothelioma to oncolytic measles virus depends on defects of the type I interferon response

https://doi.org/10.18632/oncotarget.6285

Carole Achard, Nicolas Boisgerault, Tiphaine Delaunay, David Roulois, Steven Nedellec, Pierre-Joseph Royer, Mallory Pain, Chantal Combredet, Mariana Mesel-Lemoine, Laurent Cellerin, Antoine Magnan, Frédéric Tangy, Marc Grégoire,  and Jean-François Fonteneau
44892-44904
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

mTOR kinase inhibitor pp242 causes mitophagy terminated by apoptotic cell death in E1A-Ras transformed cells

mTOR kinase inhibitor pp242 causes mitophagy terminated by apoptotic cell death in E1A-Ras transformed cells

https://doi.org/10.18632/oncotarget.6457

Serguei A. Gordeev, Tatiana V. Bykova, Svetlana G. Zubova, Olga A. Bystrova, Marina G. Martynova, Valery A. Pospelov,  and Tatiana V. Pospelova
44905-44926
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

TMSB4Y is a candidate tumor suppressor on the Y chromosome and is deleted in male breast cancer

TMSB4Y is a candidate tumor suppressor on the Y chromosome and is deleted in male breast cancer

https://doi.org/10.18632/oncotarget.6743

Hong Yuen Wong, Grace M. Wang, Sarah Croessmann, Daniel J. Zabransky, David Chu, Joseph P. Garay, Justin Cidado, Rory L. Cochran, Julia A. Beaver, Anita Aggarwal, Min-Ling Liu, Pedram Argani, Alan Meeker, Paula J. Hurley, Josh Lauring,  and Ben Ho Park
44927-44940
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The transglutaminase type 2 and pyruvate kinase isoenzyme M2 interplay in autophagy regulation

The transglutaminase type 2 and pyruvate kinase isoenzyme M2 interplay in autophagy regulation

https://doi.org/10.18632/oncotarget.6759

Sara Altuntas, Federica Rossin, Claudia Marsella, Manuela D’Eletto, Laura Diaz-Hidalgo, Maria Grazia Farrace, Michelangelo Campanella, Manuela Antonioli, Gian Maria Fimia,  and Mauro Piacentini
44941-44954
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Clinical Research Papers

Conditional survival among patients with adrenal cortical carcinoma determined using a national population-based surveillance, epidemiology, and end results registry

Conditional survival among patients with adrenal cortical carcinoma determined using a national population-based surveillance, epidemiology, and end results registry

https://doi.org/10.18632/oncotarget.5831

Wen-jun Xiao, Yao Zhu, Bo Dai, Hai-liang Zhang, Guo-hai Shi, Yi-jun Shen, Yi-ping Zhu,  and Ding-wei Ye
44955-44962
Abstract  |  PDF  |  HTML  |  Order a Reprint

Clinical significance of age at diagnosis among young non-small cell lung cancer patients under 40 years old: a population-based study

Clinical significance of age at diagnosis among young non-small cell lung cancer patients under 40 years old: a population-based study

https://doi.org/10.18632/oncotarget.5524

Mina Liu, Xuwei Cai, Wen Yu, Changxing Lv,  and Xiaolong Fu
44963-44970
Abstract  |  PDF  |  HTML  |  Order a Reprint

Phase II clinical and exploratory biomarker study of dacomitinib in recurrent and/or metastatic esophageal squamous cell carcinoma

Phase II clinical and exploratory biomarker study of dacomitinib in recurrent and/or metastatic esophageal squamous cell carcinoma

https://doi.org/10.18632/oncotarget.6056

Hyo Song Kim, Sung-Moo Kim, Hyunki Kim, Kyoung-Ho Pyo, Jong-Mu Sun, Myung-Ju Ahn, Keunchil Park, Bhumsuk Keam, Nak-Jung Kwon, Hwan Jung Yun, Hoon-Gu Kim, Ik-Joo Chung, Jong Seok Lee, Kyung Hee Lee, Dae Joon Kim, Chang‑Geol Lee, Jin Hur, Hyunsoo Chung, Jun Chul Park, Sung Kwan Shin, Sang Kil Lee, Hye Ryun Kim, Yong Wha Moon, Yong Chan Lee, Joo Hang Kim, Soonmyung Paik,  and Byoung Chul Cho
44971-44984
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A prospective, multicenter, observational study of long-term decitabine treatment in patients with myelodysplastic syndrome

A prospective, multicenter, observational study of long-term decitabine treatment in patients with myelodysplastic syndrome

https://doi.org/10.18632/oncotarget.6242

Seong Hyun Jeong, Yoo-Jin Kim, Je-Hwan Lee, Yeo-Kyeoung Kim, Soo Jeong Kim, Sung Kyu Park, Young Rok Do, Inho Kim, Yeung-Chul Mun, Hoon Gu Kim, Won Sik Lee, Hyeon Gyu Yi, Young-Don Joo, Chul Won Choi, Suk Ran Kim, Sang Min Na,  and Jun Ho Jang
44985-44994
Abstract  |  PDF  |  HTML  |  Order a Reprint

Patterns of care and treatment outcomes in older patients with biliary tract cancer

Patterns of care and treatment outcomes in older patients with biliary tract cancer

https://doi.org/10.18632/oncotarget.5707

Anne Horgan, Jennifer Knox, Priya Aneja, Lisa Le, Elizabeth McKeever,  and Mairead McNamara
44995-45004
Abstract  |  PDF  |  HTML  |  Order a Reprint

Case Reports

Cerebral hemorrhage due to tuberculosis meningitis: a rare case report and literature review

Cerebral hemorrhage due to tuberculosis meningitis: a rare case report and literature review

https://doi.org/10.18632/oncotarget.6528

Hai Zou, Ke-Hua Pan, Hong-Ying Pan, Dong-Sheng Huang,  and Ming-Hua Zheng
45005-45009
Abstract  |  PDF  |  HTML  |  Order a Reprint

News

Inhibitors of mTOR in aging and cancer

Inhibitors of mTOR in aging and cancer

https://doi.org/10.18632/oncotarget.6878

Alexander Zhavoronkov
45010-45011
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