Oncotarget

Vol 6, No 41

December 22, 2015

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Integrative omics reveals MYCN as a global suppressor of cellular signalling and enables network-based therapeutic target discovery in neuroblastoma. See Duffy et al.

Table of Contents

Editorial: Chromosome

Extracellular vesicles in smoking-related lung diseases

Extracellular vesicles in smoking-related lung diseases

https://doi.org/10.18632/oncotarget.6556

Yu Fujita, Jun Araya,  and Takahiro Ochiya
43144-43145
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Priority Research Papers

Fra-1 is a key driver of colon cancer metastasis and a Fra-1 classifier predicts disease-free survival

Fra-1 is a key driver of colon cancer metastasis and a Fra-1 classifier predicts disease-free survival

https://doi.org/10.18632/oncotarget.6454

Sedef Iskit, Andreas Schlicker, Lodewyk Wessels,  and Daniel S. Peeper
43146-43161
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SUV420H1 enhances the phosphorylation and transcription of ERK1 in cancer cells

SUV420H1 enhances the phosphorylation and transcription of ERK1 in cancer cells

https://doi.org/10.18632/oncotarget.6351

Theodore Vougiouklakis, Kenbun Sone, Vassiliki Saloura, Hyun-Soo Cho, Takehiro Suzuki, Naoshi Dohmae, Houda Alachkar, Yusuke Nakamura,  and Ryuji Hamamoto
43162-43171
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Epigenetic effects of RRx-001: a possible unifying mechanism of anticancer activity

Epigenetic effects of RRx-001: a possible unifying mechanism of anticancer activity

https://doi.org/10.18632/oncotarget.6526

Hongjuan Zhao, Shoucheng Ning, Jan Scicinski, Bryan Oronsky, Susan J. Knox,  and Donna M. Peehl
43172-43181
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Integrative omics reveals MYCN as a global suppressor of cellular signalling and enables network-based therapeutic target discovery in neuroblastoma

Integrative omics reveals MYCN as a global suppressor of cellular signalling and enables network-based therapeutic target discovery in neuroblastoma

https://doi.org/10.18632/oncotarget.6568

David J. Duffy, Aleksandar Krstic, Melinda Halasz, Thomas Schwarzl, Dirk Fey, Kristiina Iljin, Jai Prakash Mehta, Kate Killick, Jenny Whilde, Benedetta Turriziani, Saija Haapa-Paananen, Vidal Fey, Matthias Fischer, Frank Westermann, Kai-Oliver Henrich, Steffen Bannert, Desmond G. Higgins,  and Walter Kolch
43182-43201
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Research Papers: Pathology

Combination of exercise training and erythropoietin prevents cancer-induced muscle alterations

Combination of exercise training and erythropoietin prevents cancer-induced muscle alterations

https://doi.org/10.18632/oncotarget.6439

Fabrizio Pin, Silvia Busquets, Miriam Toledo, Andrea Camperi, Francisco J. Lopez-Soriano, Paola Costelli, Josep M. Argilés,  and Fabio Penna
43202-43215
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Activation of an endothelial Notch1-Jagged1 circuit induces VCAM1 expression, an effect amplified by interleukin-1β

Activation of an endothelial Notch1-Jagged1 circuit induces VCAM1 expression, an effect amplified by interleukin-1β

https://doi.org/10.18632/oncotarget.6456

Federica Verginelli, Laura Adesso, Isabelle Limon, Anna Alisi, Marie Gueguen, Nadia Panera, Ezio Giorda, Lavinia Raimondi, Roberta Ciarapica, Antonio F. Campese, Isabella Screpanti, Stefano Stifani, Jan Kitajewski, Lucio Miele, Rossella Rota,  and Franco Locatelli
43216-43229
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The NKG2D – IL-15 signaling pathway contributes to T-cell mediated pathology in inflammatory myopathies

The NKG2D – IL-15 signaling pathway contributes to T-cell mediated pathology in inflammatory myopathies

https://doi.org/10.18632/oncotarget.6462

Tobias Ruck, Stefan Bittner, Ali Maisam Afzali, Kerstin Göbel, Sarah Glumm, Peter Kraft, Claudia Sommer, Christoph Kleinschnitz, Corinna Preuße, Werner Stenzel, Heinz Wiendl,  and Sven G. Meuth
43230-43243
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Molecular classification of non-invasive breast lesions for personalised therapy and chemoprevention

Molecular classification of non-invasive breast lesions for personalised therapy and chemoprevention

https://doi.org/10.18632/oncotarget.6525

Niamh Buckley, David Boyle, Darragh McArt, Gareth Irwin, D. Paul Harkin, Tong Lioe, Stephen McQuaid, Jacqueline A. James, Perry Maxwell, Peter Hamilton, Paul B. Mullan,  and Manuel Salto-Tellez
43244-43254
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Research Papers: Immunology

Validation of a multicolor staining to monitor phosphoSTAT5 levels in regulatory T-cell subsets

Validation of a multicolor staining to monitor phosphoSTAT5 levels in regulatory T-cell subsets

https://doi.org/10.18632/oncotarget.6486

Grégory Ehx, Muriel Hannon, Yves Beguin, Stéphanie Humblet-Baron,  and Frédéric Baron
43255-43266
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IL-27 induces the expression of IDO and PD-L1 in human cancer cells

IL-27 induces the expression of IDO and PD-L1 in human cancer cells

https://doi.org/10.18632/oncotarget.6530

Grazia Carbotti, Gaia Barisione, Irma Airoldi, Delia Mezzanzanica, Marina Bagnoli, Simone Ferrero, Andrea Petretto, Marina Fabbi,  and Silvano Ferrini
43267-43280
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Hepatitis B virus core antigen as a carrier for Chlamydia trachomatis MOMP multi-epitope peptide enhances protection against genital chlamydial infection

Hepatitis B virus core antigen as a carrier for Chlamydia trachomatis MOMP multi-epitope peptide enhances protection against genital chlamydial infection

https://doi.org/10.18632/oncotarget.6533

Pengfei Jiang, Wangqi Du, Yirong Xiong, Yan Lv, Juan Feng, Shanli Zhu, Xiangyang Xue, Shao Chen,  and Lifang Zhang
43281-43292
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GB virus type C E2 protein inhibits human immunodeficiency virus type 1 Gag assembly by downregulating human ADP-ribosylation factor 1

GB virus type C E2 protein inhibits human immunodeficiency virus type 1 Gag assembly by downregulating human ADP-ribosylation factor 1

https://doi.org/10.18632/oncotarget.6537

Chenliang Wang, Christine L. Timmons, Qiujia Shao, Ballington L. Kinlock, Tiffany M. Turner, Aikichi Iwamoto, Hui Zhang, Huanliang Liu,  and Bindong Liu
43293-43309
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Research Papers: Chromosome

Proteasome inhibition mediates p53 reactivation and anti-cancer activity of 6-Gingerol in cervical cancer cells

Proteasome inhibition mediates p53 reactivation and anti-cancer activity of 6-Gingerol in cervical cancer cells

https://doi.org/10.18632/oncotarget.6383

Namrata Rastogi, Shivali Duggal, Shailendra Kumar Singh, Konica Porwal, Vikas Kumar Srivastava, Rakesh Maurya, Madan L.B. Bhatt,  and Durga Prasad Mishra
43310-43325
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Reviews

Is lineage decision-making restricted during tumoral reprograming of haematopoietic stem cells?

Is lineage decision-making restricted during tumoral reprograming of haematopoietic stem cells?

https://doi.org/10.18632/oncotarget.6145

Geoffrey Brown,  and Isidro Sanchez-Garcia
43326-43341
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Research Papers

Akt inhibition improves irinotecan treatment and prevents cell emergence by switching the senescence response to apoptosis

Akt inhibition improves irinotecan treatment and prevents cell emergence by switching the senescence response to apoptosis

https://doi.org/10.18632/oncotarget.6126

Alexandra Vétillard, Barbara Jonchère, Marie Moreau, Bertrand Toutain, Cécile Henry, Simon Fontanel, Anne-Charlotte Bernard, Mario Campone, Catherine Guette,  and Olivier Coqueret
43342-43362
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Loss of COX5B inhibits proliferation and promotes senescence via mitochondrial dysfunction in breast cancer

Loss of COX5B inhibits proliferation and promotes senescence via mitochondrial dysfunction in breast cancer

https://doi.org/10.18632/oncotarget.6222

Shui-Ping Gao, He-Fen Sun, Hong-Lin Jiang, Liang-Dong Li, Xin Hu, Xiao-En Xu,  and Wei Jin
43363-43374
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Targeting CXCR1 on breast cancer stem cells: signaling pathways and clinical application modelling

Targeting CXCR1 on breast cancer stem cells: signaling pathways and clinical application modelling

https://doi.org/10.18632/oncotarget.6234

Laura Brandolini, Loredana Cristiano, Alessia Fidoamore, Maria De Pizzol, Erica Di Giacomo, Tiziana Marilena Florio, Giuseppina Confalone, Angelo Galante, Benedetta Cinque, Elisabetta Benedetti, Pier Adelchi Ruffini, Maria Grazia Cifone, Antonio Giordano, Marcello Alecci, Marcello Allegretti,  and Annamaria Cimini
43375-43394
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IRAK1 is a novel DEK transcriptional target and is essential for head and neck cancer cell survival

IRAK1 is a novel DEK transcriptional target and is essential for head and neck cancer cell survival

https://doi.org/10.18632/oncotarget.6028

Allie K. Adams, Lyndsey C. Bolanos, Phillip J. Dexheimer, Rebekah A. Karns, Bruce J. Aronow, Kakajan Komurov, Anil G. Jegga, Keith A. Casper, Yash J. Patil, Keith M. Wilson, Daniel T. Starczynowski,  and Susanne I. Wells
43395-43407
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CXCR3 as a molecular target in breast cancer metastasis: inhibition of tumor cell migration and promotion of host anti-tumor immunity

CXCR3 as a molecular target in breast cancer metastasis: inhibition of tumor cell migration and promotion of host anti-tumor immunity

https://doi.org/10.18632/oncotarget.6125

Guiquan Zhu, H. Hannah Yan, Yanli Pang, Jiang Jian, Bhagelu R. Achyut, Xinhua Liang, Jonathan M. Weiss, Robert H. Wiltrout, M. Christine Hollander,  and Li Yang
43408-43419
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VHL-dependent alterations in the secretome of renal cell carcinoma: Association with immune cell response?

VHL-dependent alterations in the secretome of renal cell carcinoma: Association with immune cell response?

https://doi.org/10.18632/oncotarget.5560

Franziska Stehle, Sandra Leisz, Kristin Schulz, Nicolle Schwurack, Nico Weber, Chiara Massa, Jana Kalich, Corinna Fahldieck,  and Barbara Seliger
43420-43437
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Collective cancer cell invasion induced by coordinated contractile stresses

Collective cancer cell invasion induced by coordinated contractile stresses

https://doi.org/10.18632/oncotarget.5874

Angela M. Jimenez Valencia, Pei-Hsun Wu, Osman N. Yogurtcu, Pranay Rao, Josh DiGiacomo, Ines Godet, Lijuan He, Meng-Horng Lee, Daniele Gilkes, Sean X. Sun,  and Denis Wirtz
43438-43451
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Elucidating the cancer-specific genetic alteration spectrum of glioblastoma derived cell lines from whole exome and RNA sequencing

Elucidating the cancer-specific genetic alteration spectrum of glioblastoma derived cell lines from whole exome and RNA sequencing

https://doi.org/10.18632/oncotarget.6171

Vikas Patil, Jagriti Pal,  and Kumaravel Somasundaram
43452-43471
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Mismatch repair gene defects in sporadic colorectal cancer enhance immune surveillance

Mismatch repair gene defects in sporadic colorectal cancer enhance immune surveillance

https://doi.org/10.18632/oncotarget.6179

Marco Scarpa, Cesare Ruffolo, Fabio Canal, Melania Scarpa, Silvia Basato, Francesca Erroi, Alain Fiorot, Lucia Dall’Agnese, Anna Pozza, Andrea Porzionato, Ignazio Castagliuolo, Angelo P. Dei Tos, Nicolò Bassi,  and Carlo Castoro
43472-43482
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Phosphorylation of Nucleophosmin at Threonine 234/237 is associated with HCC metastasis

Phosphorylation of Nucleophosmin at Threonine 234/237 is associated with HCC metastasis

https://doi.org/10.18632/oncotarget.5820

Rachel Hiu Ha Ching, Eunice Yuen Ting Lau, Patrick Ming Tat Ling, Joyce Man Fong Lee, Mark Kin Fai Ma, Bowie Yik Ling Cheng, Regina Cheuk Lam Lo, Irene Oi Lin Ng,  and Terence Kin Wah Lee
43483-43495
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CD47-retargeted oncolytic adenovirus armed with melanoma differentiation-associated gene-7/interleukin-24 suppresses in vivo leukemia cell growth

CD47-retargeted oncolytic adenovirus armed with melanoma differentiation-associated gene-7/interleukin-24 suppresses in vivo leukemia cell growth

https://doi.org/10.18632/oncotarget.6292

Gongchu Li, Hu Wu, Lianzhen Cui, Yajun Gao, Lei Chen, Xin Li, Tianxiang Liang, Xinyan Yang, Jianhong Cheng,  and Jingjing Luo
43496-43507
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Anti-leukemic effects of the V-ATPase inhibitor Archazolid A

Anti-leukemic effects of the V-ATPase inhibitor Archazolid A

https://doi.org/10.18632/oncotarget.6180

Siwei Zhang, Lina S. Schneider, Binje Vick, Michaela Grunert, Irmela Jeremias, Dirk Menche, Rolf Müller, Angelika M. Vollmar,  and Johanna Liebl
43508-43528
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Proteoglycan expression correlates with the phenotype of malignant and non-malignant EBV-positive B-cell lines

Proteoglycan expression correlates with the phenotype of malignant and non-malignant EBV-positive B-cell lines

https://doi.org/10.18632/oncotarget.5984

Alexandra Y. Tsidulko, Liudmila Matskova, Lidiia A. Astakhova, Ingemar Ernberg,  and Elvira V. Grigorieva
43529-43539
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Molecular and functional interactions between AKT and SOX2 in breast carcinoma

Molecular and functional interactions between AKT and SOX2 in breast carcinoma

https://doi.org/10.18632/oncotarget.6183

Thorsten Schaefer, Hui Wang, Perihan Mir, Martina Konantz, Tamara C. Pereboom, Anna M. Paczulla, Britta Merz, Tanja Fehm, Sven Perner, Oliver C. Rothfuss, Lothar Kanz, Klaus Schulze-Osthoff,  and Claudia Lengerke
43540-43556
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Negative regulation of EB1 turnover at microtubule plus ends by interaction with microtubule-associated protein ATIP3

Negative regulation of EB1 turnover at microtubule plus ends by interaction with microtubule-associated protein ATIP3

https://doi.org/10.18632/oncotarget.6196

Lauriane Velot, Angie Molina, Sylvie Rodrigues-Ferreira, Anne Nehlig, Benjamin Pierre Bouchet, Marina Morel, Ludovic Leconte, Laurence Serre, Isabelle Arnal, Diane Braguer, Ariel Savina, Stéphane Honore,  and Clara Nahmias
43557-43570
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Is magnetic resonance/ultrasound fusion prostate biopsy better than systematic prostate biopsy? an updated meta- and trial sequential analysis

Is magnetic resonance/ultrasound fusion prostate biopsy better than systematic prostate biopsy? an updated meta- and trial sequential analysis

https://doi.org/10.18632/oncotarget.6201

Jian Wu, Alin Ji, Bo Xie, Xiao Wang, Yi Zhu, Junyuan Wang, Yasai Yu, Xiangyi Zheng, Ben Liu,  and Liping Xie
43571-43580
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Tumor growth suppression by inhibiting both autophagy and STAT3 signaling in HNSCC

Tumor growth suppression by inhibiting both autophagy and STAT3 signaling in HNSCC

https://doi.org/10.18632/oncotarget.6294

Teng-Fei Fan, Lin-Lin Bu, Wei-Ming Wang, Si-Rui Ma, Jian-Feng Liu, Wei-Wei Deng, Liang Mao, Guang-Tao Yu, Cong-Fa Huang, Bing Liu, Wen-Feng Zhang,  and Zhi-Jun Sun
43581-43593
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Comprehensive multiplatform biomarker analysis of 199 anal squamous cell carcinomas

Comprehensive multiplatform biomarker analysis of 199 anal squamous cell carcinomas

https://doi.org/10.18632/oncotarget.6202

Brandon G. Smaglo, Anteneh Tesfaye, Thorvardur R. Halfdanarson, Joshua E. Meyer, Jue Wang, Zoran Gatalica, Sandeep Reddy, David Arguello,  and Patrick M. Boland
43594-43604
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Metformin attenuates gefitinib-induced exacerbation of pulmonary fibrosis by inhibition of TGF-β signaling pathway

Metformin attenuates gefitinib-induced exacerbation of pulmonary fibrosis by inhibition of TGF-β signaling pathway

https://doi.org/10.18632/oncotarget.6186

Li Li, Wenting Huang, Kunlin Li, Kejun Zhang, Caiyu Lin, Rui Han, Conghua Lu, Yubo Wang, Hengyi Chen, Fenfen Sun,  and Yong He
43605-43619
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RNA-binding protein CELF1 promotes tumor growth and alters gene expression in oral squamous cell carcinoma

RNA-binding protein CELF1 promotes tumor growth and alters gene expression in oral squamous cell carcinoma

https://doi.org/10.18632/oncotarget.6204

Reniqua P. House, Sudha Talwar, E. Starr Hazard, Elizabeth G. Hill,  and Viswanathan Palanisamy
43620-43634
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Integrative analysis to select cancer candidate biomarkers to targeted validation

Integrative analysis to select cancer candidate biomarkers to targeted validation

https://doi.org/10.18632/oncotarget.6018

Rebeca Kawahara, Gabriela V. Meirelles, Henry Heberle, Romênia R. Domingues, Daniela C. Granato, Sami Yokoo, Rafael R. Canevarolo, Flavia V. Winck, Ana Carolina P. Ribeiro, Thaís Bianca Brandão, Paulo R. Filgueiras, Karen S. P. Cruz, José Alexandre Barbuto, Ronei J. Poppi, Rosane Minghim, Guilherme P. Telles, Felipe Paiva Fonseca, Jay W. Fox, Alan R. Santos-Silva, Ricardo D. Coletta, Nicholas E. Sherman,  and Adriana F. Paes Leme
43635-43652
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Genomic dynamics associated with malignant transformation in IDH1 mutated gliomas

Genomic dynamics associated with malignant transformation in IDH1 mutated gliomas

https://doi.org/10.18632/oncotarget.6189

Chul-Kee Park, Inho Park, Seungmook Lee, Choong-Hyun Sun, Youngil Koh, Sung-Hye Park, Ja Eun Kim, Hongseok Yun,  and Se-Hoon Lee
43653-43666
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Cigarette smoking during pregnancy and preeclampsia risk: a systematic review and meta-analysis of prospective studies

Cigarette smoking during pregnancy and preeclampsia risk: a systematic review and meta-analysis of prospective studies

https://doi.org/10.18632/oncotarget.6190

Jun Wei, Cai-Xia Liu, Ting-Ting Gong, Qi-Jun Wu,  and Lang Wu
43667-43678
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

5-Fluorouracil-induced RNA stress engages a TRAIL-DISC-dependent apoptosis axis facilitated by p53

5-Fluorouracil-induced RNA stress engages a TRAIL-DISC-dependent apoptosis axis facilitated by p53

https://doi.org/10.18632/oncotarget.6030

Birce Akpinar, Ethiene V. Bracht, Dorin Reijnders, Barbora Safarikova, Iva Jelinkova, Alf Grandien, Alena Hyrslova Vaculova, Boris Zhivotovsky,  and Magnus Olsson
43679-43697
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Liposomal doxorubicin for active targeting: surface modification of the nanocarrier evaluated in vitro and in vivo — challenges and prospects

Liposomal doxorubicin for active targeting: surface modification of the nanocarrier evaluated in vitro and in vivo — challenges and prospects

https://doi.org/10.18632/oncotarget.6191

Judith Jakoby, Felix Beuschlein, Susanne Mentz, Constanze Hantel,  and Regine Süss
43698-43711
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miR-192 suppresses leptomeningeal dissemination of medulloblastoma by modulating cell proliferation and anchoring through the regulation of DHFR, integrins, and CD47

miR-192 suppresses leptomeningeal dissemination of medulloblastoma by modulating cell proliferation and anchoring through the regulation of DHFR, integrins, and CD47

https://doi.org/10.18632/oncotarget.6227

Seung Yeob Yang, Seung Ah Choi, Ji Yeoun Lee, Ae-Kyung Park, Kyu-Chang Wang, Ji Hoon Phi, Eun Jung Koh, Woong-Yang Park, Sung-Hye Park, Do Won Hwang, Hee Won Jung,  and Seung-Ki Kim
43712-43730
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Mutational profiling of brain metastasis from breast cancer: matched pair analysis of targeted sequencing between brain metastasis and primary breast cancer

Mutational profiling of brain metastasis from breast cancer: matched pair analysis of targeted sequencing between brain metastasis and primary breast cancer

https://doi.org/10.18632/oncotarget.6192

Ji Yun Lee, Kyunghee Park, Sung Hee Lim, Hae Su Kim, Kwai Han Yoo, Ki Sun Jung, Haa-Na Song, Mineui Hong, In-Gu Do, TaeJin Ahn, Se Kyung Lee, Soo Youn Bae, Seok Won Kim, Jeong Eon Lee, Seok Jin Nam, Duk-Hwan Kim, Hae Hyun Jung, Ji-Yeon Kim, Jin Seok Ahn, Young-Hyuck Im,  and Yeon Hee Park
43731-43742
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Dysregulated expression of cell surface glycoprotein CDCP1 in prostate cancer

Dysregulated expression of cell surface glycoprotein CDCP1 in prostate cancer

https://doi.org/10.18632/oncotarget.6193

Lifang Yang, Sucharita M. Dutta, Dean A. Troyer, Jefferson B. Lin, Raymond A. Lance, Julius O. Nyalwidhe, Richard R Drake,  and O. John Semmes
43743-43758
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Characterization and bioactivity of novel calcium antagonists - N-methoxy-benzyl haloperidol quaternary ammonium salt

Characterization and bioactivity of novel calcium antagonists - N-methoxy-benzyl haloperidol quaternary ammonium salt

https://doi.org/10.18632/oncotarget.6086

Yi-Cun Chen, Wei Zhu, Shu-Ping Zhong, Fu-Chun Zheng, Fen-Fei Gao, Yan-Mei Zhang, Han Xu, Yan-Shan Zheng,  and Gang-Gang Shi
43759-43769
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Long non-coding RNA expression profiles of hepatitis C virus-related dysplasia and hepatocellular carcinoma

Long non-coding RNA expression profiles of hepatitis C virus-related dysplasia and hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.6087

Haohai Zhang, Chengpei Zhu, Yi Zhao, Ming Li, Liangcai Wu, Xiaobo Yang, Xueshuai Wan, Anqiang Wang, Michael Q. Zhang, Xinting Sang,  and Haitao Zhao
43770-43778
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Enhanced therapeutic effect of Adriamycin on multidrug resistant breast cancer by the ABCG2-siRNA loaded polymeric nanoparticles assisted with ultrasound

Enhanced therapeutic effect of Adriamycin on multidrug resistant breast cancer by the ABCG2-siRNA loaded polymeric nanoparticles assisted with ultrasound

https://doi.org/10.18632/oncotarget.6085

Min Bai, Ming Shen, Yanwei Teng, Ying Sun, Fan Li, Xiangyu Zhang, Yuanyuan Xu, Yourong Duan,  and Lianfang Du
43779-43790
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Beyond proliferation: KLF5 promotes angiogenesis of bladder cancer through directly regulating VEGFA transcription

Beyond proliferation: KLF5 promotes angiogenesis of bladder cancer through directly regulating VEGFA transcription

https://doi.org/10.18632/oncotarget.6101

Yang Gao, Kaijie Wu, Yule Chen, Jiancheng Zhou, Chong Du, Qi Shi, Shan Xu, Jing Jia, Xiaoshuang Tang, Feng Li, Ke Hui, Dalin He,  and Peng Guo
43791-43805
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Inhibition of p300 lysine acetyltransferase activity by luteolin reduces tumor growth in head and neck squamous cell carcinoma (HNSCC) xenograft mouse model

Inhibition of p300 lysine acetyltransferase activity by luteolin reduces tumor growth in head and neck squamous cell carcinoma (HNSCC) xenograft mouse model

https://doi.org/10.18632/oncotarget.6245

Ruthrotha B. Selvi, Amrutha Swaminathan, Snehajyoti Chatterjee, Muthu K. Shanmugam, Feng Li, Gowsica B. Ramakrishnan, Kodappully Sivaraman Siveen, Arunachalam Chinnathambi, M. Emam Zayed, Sulaiman Ali Alharbi, Jeelan Basha, Akshay Bhat, Madavan Vasudevan, Arunasalam Dharmarajan, Gautam Sethi,  and Tapas K. Kundu
43806-43818
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Screening key microRNAs for castration-resistant prostate cancer based on miRNA/mRNA functional synergistic network

Screening key microRNAs for castration-resistant prostate cancer based on miRNA/mRNA functional synergistic network

https://doi.org/10.18632/oncotarget.6102

Jin Zhu, Sugui Wang, Wenyu Zhang, Junyi Qiu, Yuxi Shan, Dongrong Yang,  and Bairong Shen
43819-43830
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The miR-24-Bim pathway promotes tumor growth and angiogenesis in pancreatic carcinoma

The miR-24-Bim pathway promotes tumor growth and angiogenesis in pancreatic carcinoma

https://doi.org/10.18632/oncotarget.6257

Rui Liu, Haiyang Zhang, Xia Wang, Likun Zhou, Hongli Li, Ting Deng, Yanjun Qu, Jingjing Duan, Ming Bai, Shaohua Ge, Tao Ning, Le Zhang, Dingzhi Huang,  and Yi Ba
43831-43842
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

CSIOVDB: a microarray gene expression database of epithelial ovarian cancer subtype

CSIOVDB: a microarray gene expression database of epithelial ovarian cancer subtype

https://doi.org/10.18632/oncotarget.5983

Tuan Zea Tan, He Yang, Jieru Ye, Jeffrey Low, Mahesh Choolani, David Shao Peng Tan, Jean-Paul Thiery,  and Ruby Yun-Ju Huang
43843-43852
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

p21-activated kinase group II small compound inhibitor GNE-2861 perturbs estrogen receptor alpha signaling and restores tamoxifen-sensitivity in breast cancer cells

p21-activated kinase group II small compound inhibitor GNE-2861 perturbs estrogen receptor alpha signaling and restores tamoxifen-sensitivity in breast cancer cells

https://doi.org/10.18632/oncotarget.6081

Ting Zhuang, Jian Zhu, Zhilun Li, Julie Lorent, Chunyan Zhao, Karin Dahlman-Wright,  and Staffan Strömblad
43853-43868
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MALDI-imaging reveals thymosin beta-4 as an independent prognostic marker for colorectal cancer

MALDI-imaging reveals thymosin beta-4 as an independent prognostic marker for colorectal cancer

https://doi.org/10.18632/oncotarget.6103

Timo Gemoll, Sarah Strohkamp, Katharina Schillo, Christoph Thorns,  and Jens K. Habermann
43869-43880
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Cerdulatinib, a novel dual SYK/JAK kinase inhibitor, has broad anti-tumor activity in both ABC and GCB types of diffuse large B cell lymphoma

Cerdulatinib, a novel dual SYK/JAK kinase inhibitor, has broad anti-tumor activity in both ABC and GCB types of diffuse large B cell lymphoma

https://doi.org/10.18632/oncotarget.6316

Jiao Ma, Wei Xing, Greg Coffey, Karen Dresser, Kellie Lu, Ailin Guo, Gordana Raca, Anjali Pandey, Pamela Conley, Hongbo Yu,  and Lynn Y. Wang
43881-43896
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The putative oncogene, CRNDE, is a negative prognostic factor in ovarian cancer patients

The putative oncogene, CRNDE, is a negative prognostic factor in ovarian cancer patients

https://doi.org/10.18632/oncotarget.6016

Lukasz Michal Szafron, Anna Balcerak, Ewa Anna Grzybowska, Barbara Pienkowska-Grela, Agnieszka Podgorska, Renata Zub, Magdalena Olbryt, Jolanta Pamula-Pilat, Katarzyna M. Lisowska, Ewa Grzybowska, Tymon Rubel, Agnieszka Dansonka-Mieszkowska, Bozena Konopka, Magdalena Kulesza, Martyna Lukasik,  and Jolanta Kupryjanczyk
43897-43910
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Glycyrrhetinic acid induces cytoprotective autophagy via the inositol-requiring enzyme 1α-c-Jun N-terminal kinase cascade in non-small cell lung cancer cells

Glycyrrhetinic acid induces cytoprotective autophagy via the inositol-requiring enzyme 1α-c-Jun N-terminal kinase cascade in non-small cell lung cancer cells

https://doi.org/10.18632/oncotarget.6084

Zheng-Hai Tang, Le-Le Zhang, Ting Li, Jia-Hong Lu, Dik-Lung Ma, Chung-Hang Leung, Xiu-Ping Chen, Hu-Lin Jiang, Yi-Tao Wang,  and Jin-Jian Lu
43911-43926
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Sorafenib, a multikinase inhibitor, induces formation of stress granules in hepatocarcinoma cells

Sorafenib, a multikinase inhibitor, induces formation of stress granules in hepatocarcinoma cells

https://doi.org/10.18632/oncotarget.5980

Pauline Adjibade, Valerie Grenier St-Sauveur, Miguel Quevillon-huberdeau, Marie Josée Fournier, Andreanne Savard, Laetitia Coudert, Edouard W Khandjian,  and Rachid Mazroui
43927-43943
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The ascidian natural product eusynstyelamide B is a novel topoisomerase II poison that induces DNA damage and growth arrest in prostate and breast cancer cells

The ascidian natural product eusynstyelamide B is a novel topoisomerase II poison that induces DNA damage and growth arrest in prostate and breast cancer cells

https://doi.org/10.18632/oncotarget.6267

Michelle S. Liberio, Martin C. Sadowski, Rohan A. Davis, Anja Rockstroh, Raj Vasireddy, Melanie L. Lehman,  and Colleen C. Nelson
43944-43963
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Invasive oral cancer stem cells display resistance to ionising radiation

Invasive oral cancer stem cells display resistance to ionising radiation

https://doi.org/10.18632/oncotarget.6268

Emilios Gemenetzidis, Luke Gammon, Adrian Biddle, Helena Emich,  and Ian Mackenzie
43964-43977
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

PARP1 expression, activity and ex vivo sensitivity to the PARP inhibitor, talazoparib (BMN 673), in chronic lymphocytic leukaemia

PARP1 expression, activity and ex vivo sensitivity to the PARP inhibitor, talazoparib (BMN 673), in chronic lymphocytic leukaemia

https://doi.org/10.18632/oncotarget.6287

Ashleigh Herriott, Susan J. Tudhope, Gesa Junge, Natalie Rodrigues, Miranda J. Patterson, Laura Woodhouse, John Lunec, Jill E. Hunter, Evan A. Mulligan, Michael Cole, Lisa M. Allinson, Jonathan P. Wallis, Scott Marshall, Evelyn Wang, Nicola J. Curtin,  and Elaine Willmore
43978-43991
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The bone marrow microenvironment enhances multiple myeloma progression by exosome-mediated activation of myeloid-derived suppressor cells

The bone marrow microenvironment enhances multiple myeloma progression by exosome-mediated activation of myeloid-derived suppressor cells

https://doi.org/10.18632/oncotarget.6083

Jinheng Wang, Kim De Veirman, Nathan De Beule, Ken Maes, Elke De Bruyne, Els Van Valckenborgh, Karin Vanderkerken,  and Eline Menu
43992-44004
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Clinical Research Papers

Neoadjuvant chemotherapy (NCT) plus targeted agents versus NCT alone in colorectal liver metastases patients: A systematic review and meta-analysis

Neoadjuvant chemotherapy (NCT) plus targeted agents versus NCT alone in colorectal liver metastases patients: A systematic review and meta-analysis

https://doi.org/10.18632/oncotarget.5875

Chun-Hui Cui, Shu-Xin Huang, Jia Qi, Hui-Juan Zhu, Zong-Hai Huang,  and Jin-Long Yu
44005-44018
Abstract  |  PDF  |  HTML  |  Order a Reprint

Propensity score matching analysis of cisplatin-based concurrent chemotherapy in low risk nasopharyngeal carcinoma in the intensity-modulated radiotherapy era

Propensity score matching analysis of cisplatin-based concurrent chemotherapy in low risk nasopharyngeal carcinoma in the intensity-modulated radiotherapy era

https://doi.org/10.18632/oncotarget.5806

Lu-Ning Zhang, Yuan-Hong Gao, Xiao-Wen Lan, Jie Tang, Zhen Su, Jun Ma, Wuguo Deng, Pu-Yun OuYang,  and Fang-Yun Xie
44019-44029
Abstract  |  PDF  |  HTML  |  Order a Reprint

Distribution of metastatic disease in the brain in relation to the hippocampus: a retrospective single-center analysis of 6064 metastases in 632 patients

Distribution of metastatic disease in the brain in relation to the hippocampus: a retrospective single-center analysis of 6064 metastases in 632 patients

https://doi.org/10.18632/oncotarget.5828

San-Gang Wu, Ming-Yue Rao, Juan Zhou, Qin Lin, Zi-Jing Wang, Yong-Xiong Chen,  and Zhen-Yu He
44030-44036
Abstract  |  PDF  |  HTML  |  Order a Reprint

Serum apolipoprotein A-I is a novel prognostic indicator for non-metastatic nasopharyngeal carcinoma

Serum apolipoprotein A-I is a novel prognostic indicator for non-metastatic nasopharyngeal carcinoma

https://doi.org/10.18632/oncotarget.5823

Xiao-Lin Luo, Guang-Zheng Zhong, Li-Yang Hu, Jie Chen, Ying Liang, Qiu-Yan Chen, Qing Liu, Hui-Lan Rao, Kai-Lin Chen,  and Qing-Qing Cai
44037-44048
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Puquitinib mesylate, an inhibitor of phosphatidylinositol 3-kinase p110δ, for treating relapsed or refractory non-Hodgkin’s lymphoma

Puquitinib mesylate, an inhibitor of phosphatidylinositol 3-kinase p110δ, for treating relapsed or refractory non-Hodgkin’s lymphoma

https://doi.org/10.18632/oncotarget.5833

Hang Yang, Yu Wang, Jing Zhan, Yi Xia, Peng Sun, Xi-Wen Bi, Pan-Pan Liu, Zhi-Ming Li, Su Li, Ben-Yan Zou,  and Wen-Qi Jiang
44049-44056
Abstract  |  PDF  |  HTML  |  Order a Reprint


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